-- dump date   	20140619_013832
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
320389000001	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
320389000002	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
320389000003	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
320389000004	active site
320389000005	Int/Topo IB signature motif; other site
320389000006	catalytic residues [active]
320389000007	DNA binding site [nucleotide binding]
320389000008	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
320389000009	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
320389000010	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389000011	non-specific DNA binding site [nucleotide binding]; other site
320389000012	salt bridge; other site
320389000013	sequence-specific DNA binding site [nucleotide binding]; other site
320389000014	Cupin domain; Region: Cupin_2; pfam07883
320389000015	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
320389000016	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
320389000017	substrate-cofactor binding pocket; other site
320389000018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389000019	catalytic residue [active]
320389000020	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
320389000021	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
320389000022	NAD(P) binding site [chemical binding]; other site
320389000023	Uncharacterized conserved protein [Function unknown]; Region: COG2353
320389000024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389000025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389000026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
320389000027	SnoaL-like domain; Region: SnoaL_2; pfam12680
320389000028	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
320389000029	putative active site [active]
320389000030	Zn binding site [ion binding]; other site
320389000031	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
320389000032	tartrate dehydrogenase; Region: TTC; TIGR02089
320389000033	transcriptional activator TtdR; Provisional; Region: PRK09801
320389000034	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000035	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
320389000036	putative effector binding pocket; other site
320389000037	putative dimerization interface [polypeptide binding]; other site
320389000038	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
320389000039	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
320389000040	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
320389000041	putative C-terminal domain interface [polypeptide binding]; other site
320389000042	putative GSH binding site (G-site) [chemical binding]; other site
320389000043	putative dimer interface [polypeptide binding]; other site
320389000044	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
320389000045	putative N-terminal domain interface [polypeptide binding]; other site
320389000046	putative dimer interface [polypeptide binding]; other site
320389000047	putative substrate binding pocket (H-site) [chemical binding]; other site
320389000048	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
320389000049	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
320389000050	nucleophile elbow; other site
320389000051	Patatin phospholipase; Region: DUF3734; pfam12536
320389000052	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
320389000053	classical (c) SDRs; Region: SDR_c; cd05233
320389000054	NAD(P) binding site [chemical binding]; other site
320389000055	active site
320389000056	acetoacetate decarboxylase; Provisional; Region: PRK02265
320389000057	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
320389000058	active site
320389000059	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
320389000060	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
320389000061	FAD binding pocket [chemical binding]; other site
320389000062	FAD binding motif [chemical binding]; other site
320389000063	phosphate binding motif [ion binding]; other site
320389000064	NAD binding pocket [chemical binding]; other site
320389000065	Predicted transcriptional regulators [Transcription]; Region: COG1695
320389000066	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
320389000067	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
320389000068	Cytochrome P450; Region: p450; cl12078
320389000069	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
320389000070	Protein of unknown function (DUF692); Region: DUF692; cl01263
320389000071	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
320389000072	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
320389000073	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389000074	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
320389000075	FeS/SAM binding site; other site
320389000076	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389000077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389000078	S-adenosylmethionine binding site [chemical binding]; other site
320389000079	Lysine efflux permease [General function prediction only]; Region: COG1279
320389000080	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
320389000081	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000082	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389000083	dimerization interface [polypeptide binding]; other site
320389000084	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
320389000085	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
320389000086	ligand binding site [chemical binding]; other site
320389000087	flexible hinge region; other site
320389000088	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
320389000089	putative switch regulator; other site
320389000090	non-specific DNA interactions [nucleotide binding]; other site
320389000091	DNA binding site [nucleotide binding]
320389000092	sequence specific DNA binding site [nucleotide binding]; other site
320389000093	putative cAMP binding site [chemical binding]; other site
320389000094	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389000095	Ligand Binding Site [chemical binding]; other site
320389000096	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
320389000097	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
320389000098	dimer interface [polypeptide binding]; other site
320389000099	NADP binding site [chemical binding]; other site
320389000100	catalytic residues [active]
320389000101	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
320389000102	HTH-like domain; Region: HTH_21; pfam13276
320389000103	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000104	Integrase core domain; Region: rve; pfam00665
320389000105	Integrase core domain; Region: rve_3; pfam13683
320389000106	Transposase; Region: HTH_Tnp_1; pfam01527
320389000107	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
320389000108	Strictosidine synthase; Region: Str_synth; pfam03088
320389000109	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
320389000110	Transcriptional activator HlyU; Region: HlyU; cl02273
320389000111	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
320389000112	serine O-acetyltransferase; Region: cysE; TIGR01172
320389000113	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
320389000114	trimer interface [polypeptide binding]; other site
320389000115	active site
320389000116	substrate binding site [chemical binding]; other site
320389000117	CoA binding site [chemical binding]; other site
320389000118	short chain dehydrogenase; Provisional; Region: PRK09134
320389000119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389000120	NAD(P) binding site [chemical binding]; other site
320389000121	active site
320389000122	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
320389000123	GTP cyclohydrolase I; Provisional; Region: PLN03044
320389000124	active site
320389000125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389000126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000127	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
320389000128	substrate binding pocket [chemical binding]; other site
320389000129	dimerization interface [polypeptide binding]; other site
320389000130	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
320389000131	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
320389000132	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
320389000133	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
320389000134	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
320389000135	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
320389000136	tetramer interface [polypeptide binding]; other site
320389000137	active site
320389000138	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
320389000139	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
320389000140	benzoate transport; Region: 2A0115; TIGR00895
320389000141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000142	putative substrate translocation pore; other site
320389000143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000144	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389000145	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
320389000146	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
320389000147	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
320389000148	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
320389000149	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
320389000150	RNA polymerase sigma factor; Provisional; Region: PRK11922
320389000151	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389000152	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389000153	DNA binding residues [nucleotide binding]
320389000154	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
320389000155	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
320389000156	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
320389000157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389000158	Walker A/P-loop; other site
320389000159	ATP binding site [chemical binding]; other site
320389000160	Q-loop/lid; other site
320389000161	ABC transporter signature motif; other site
320389000162	Walker B; other site
320389000163	D-loop; other site
320389000164	H-loop/switch region; other site
320389000165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389000166	Walker A/P-loop; other site
320389000167	ATP binding site [chemical binding]; other site
320389000168	Q-loop/lid; other site
320389000169	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
320389000170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389000171	Walker A/P-loop; other site
320389000172	ATP binding site [chemical binding]; other site
320389000173	Q-loop/lid; other site
320389000174	ABC transporter signature motif; other site
320389000175	Walker B; other site
320389000176	D-loop; other site
320389000177	H-loop/switch region; other site
320389000178	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
320389000179	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
320389000180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000181	putative substrate translocation pore; other site
320389000182	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389000183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389000184	active site
320389000185	phosphorylation site [posttranslational modification]
320389000186	intermolecular recognition site; other site
320389000187	dimerization interface [polypeptide binding]; other site
320389000188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389000189	Walker A motif; other site
320389000190	ATP binding site [chemical binding]; other site
320389000191	Walker B motif; other site
320389000192	arginine finger; other site
320389000193	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389000194	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
320389000195	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389000196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389000197	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
320389000198	Phosphoesterase family; Region: Phosphoesterase; pfam04185
320389000199	Domain of unknown function (DUF756); Region: DUF756; pfam05506
320389000200	Domain of unknown function (DUF756); Region: DUF756; pfam05506
320389000201	Transposase; Region: HTH_Tnp_1; pfam01527
320389000202	HTH-like domain; Region: HTH_21; pfam13276
320389000203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000204	Integrase core domain; Region: rve; pfam00665
320389000205	Integrase core domain; Region: rve_3; pfam13683
320389000206	Chain length determinant protein; Region: Wzz; pfam02706
320389000207	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
320389000208	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
320389000209	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
320389000210	Phospholipid methyltransferase; Region: PEMT; cl17370
320389000211	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
320389000212	peptidase domain interface [polypeptide binding]; other site
320389000213	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
320389000214	active site
320389000215	catalytic triad [active]
320389000216	calcium binding site [ion binding]; other site
320389000217	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
320389000218	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389000219	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389000220	metal binding site [ion binding]; metal-binding site
320389000221	active site
320389000222	I-site; other site
320389000223	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389000224	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
320389000225	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
320389000226	short chain dehydrogenase; Provisional; Region: PRK06181
320389000227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389000228	NAD(P) binding site [chemical binding]; other site
320389000229	active site
320389000230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389000231	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389000232	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000233	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389000234	putative effector binding pocket; other site
320389000235	dimerization interface [polypeptide binding]; other site
320389000236	HTH-like domain; Region: HTH_21; pfam13276
320389000237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000238	Integrase core domain; Region: rve; pfam00665
320389000239	Integrase core domain; Region: rve_3; pfam13683
320389000240	Transposase; Region: HTH_Tnp_1; pfam01527
320389000241	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
320389000242	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
320389000243	putative C-terminal domain interface [polypeptide binding]; other site
320389000244	putative GSH binding site (G-site) [chemical binding]; other site
320389000245	putative dimer interface [polypeptide binding]; other site
320389000246	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
320389000247	putative N-terminal domain interface [polypeptide binding]; other site
320389000248	putative dimer interface [polypeptide binding]; other site
320389000249	putative substrate binding pocket (H-site) [chemical binding]; other site
320389000250	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
320389000251	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
320389000252	Nucleoside recognition; Region: Gate; pfam07670
320389000253	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
320389000254	deoxyribose-phosphate aldolase; Provisional; Region: PRK05283
320389000255	catalytic residue [active]
320389000256	thymidine phosphorylase; Region: T_phosphoryl; TIGR02643
320389000257	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
320389000258	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
320389000259	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
320389000260	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
320389000261	active site
320389000262	catalytic motif [active]
320389000263	Zn binding site [ion binding]; other site
320389000264	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
320389000265	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
320389000266	BON domain; Region: BON; pfam04972
320389000267	BON domain; Region: BON; pfam04972
320389000268	6-phosphofructokinase 2; Provisional; Region: PRK10294
320389000269	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
320389000270	putative substrate binding site [chemical binding]; other site
320389000271	putative ATP binding site [chemical binding]; other site
320389000272	acetate kinase; Provisional; Region: PRK07058
320389000273	propionate/acetate kinase; Provisional; Region: PRK12379
320389000274	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
320389000275	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
320389000276	dimer interaction site [polypeptide binding]; other site
320389000277	substrate-binding tunnel; other site
320389000278	active site
320389000279	catalytic site [active]
320389000280	substrate binding site [chemical binding]; other site
320389000281	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
320389000282	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
320389000283	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
320389000284	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
320389000285	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
320389000286	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
320389000287	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
320389000288	alpha subunit interaction interface [polypeptide binding]; other site
320389000289	Walker A motif; other site
320389000290	ATP binding site [chemical binding]; other site
320389000291	Walker B motif; other site
320389000292	inhibitor binding site; inhibition site
320389000293	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
320389000294	F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447
320389000295	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
320389000296	gamma subunit interface [polypeptide binding]; other site
320389000297	epsilon subunit interface [polypeptide binding]; other site
320389000298	LBP interface [polypeptide binding]; other site
320389000299	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
320389000300	F0F1 ATP synthase subunit A; Provisional; Region: PRK13421
320389000301	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
320389000302	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
320389000303	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
320389000304	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
320389000305	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
320389000306	Walker A motif; other site
320389000307	ATP binding site [chemical binding]; other site
320389000308	Walker B motif; other site
320389000309	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
320389000310	ATP synthase; Region: ATP-synt; pfam00231
320389000311	core domain interface [polypeptide binding]; other site
320389000312	delta subunit interface [polypeptide binding]; other site
320389000313	epsilon subunit interface [polypeptide binding]; other site
320389000314	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
320389000315	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
320389000316	NAD binding site [chemical binding]; other site
320389000317	substrate binding site [chemical binding]; other site
320389000318	catalytic Zn binding site [ion binding]; other site
320389000319	tetramer interface [polypeptide binding]; other site
320389000320	structural Zn binding site [ion binding]; other site
320389000321	Cache domain; Region: Cache_2; pfam08269
320389000322	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
320389000323	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389000324	dimer interface [polypeptide binding]; other site
320389000325	putative CheW interface [polypeptide binding]; other site
320389000326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389000327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389000328	dimer interface [polypeptide binding]; other site
320389000329	phosphorylation site [posttranslational modification]
320389000330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389000331	ATP binding site [chemical binding]; other site
320389000332	Mg2+ binding site [ion binding]; other site
320389000333	G-X-G motif; other site
320389000334	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
320389000335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389000336	active site
320389000337	phosphorylation site [posttranslational modification]
320389000338	intermolecular recognition site; other site
320389000339	dimerization interface [polypeptide binding]; other site
320389000340	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
320389000341	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
320389000342	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
320389000343	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
320389000344	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
320389000345	Walker A/P-loop; other site
320389000346	ATP binding site [chemical binding]; other site
320389000347	Q-loop/lid; other site
320389000348	ABC transporter signature motif; other site
320389000349	Walker B; other site
320389000350	D-loop; other site
320389000351	H-loop/switch region; other site
320389000352	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
320389000353	Walker A/P-loop; other site
320389000354	ATP binding site [chemical binding]; other site
320389000355	Q-loop/lid; other site
320389000356	ABC transporter signature motif; other site
320389000357	Walker B; other site
320389000358	D-loop; other site
320389000359	H-loop/switch region; other site
320389000360	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
320389000361	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
320389000362	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
320389000363	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389000364	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389000365	Ligand Binding Site [chemical binding]; other site
320389000366	Protein of unknown function (DUF2964); Region: DUF2964; pfam11177
320389000367	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
320389000368	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
320389000369	FtsX-like permease family; Region: FtsX; pfam02687
320389000370	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
320389000371	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
320389000372	Walker A/P-loop; other site
320389000373	ATP binding site [chemical binding]; other site
320389000374	Q-loop/lid; other site
320389000375	ABC transporter signature motif; other site
320389000376	Walker B; other site
320389000377	D-loop; other site
320389000378	H-loop/switch region; other site
320389000379	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
320389000380	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389000381	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
320389000382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
320389000383	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389000384	dimer interface [polypeptide binding]; other site
320389000385	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
320389000386	putative CheW interface [polypeptide binding]; other site
320389000387	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
320389000388	ligand-binding site [chemical binding]; other site
320389000389	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
320389000390	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
320389000391	BON domain; Region: BON; pfam04972
320389000392	BON domain; Region: BON; pfam04972
320389000393	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
320389000394	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
320389000395	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
320389000396	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
320389000397	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
320389000398	putative NAD(P) binding site [chemical binding]; other site
320389000399	putative substrate binding site [chemical binding]; other site
320389000400	catalytic Zn binding site [ion binding]; other site
320389000401	structural Zn binding site [ion binding]; other site
320389000402	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
320389000403	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
320389000404	ligand binding site [chemical binding]; other site
320389000405	flexible hinge region; other site
320389000406	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
320389000407	putative switch regulator; other site
320389000408	non-specific DNA interactions [nucleotide binding]; other site
320389000409	DNA binding site [nucleotide binding]
320389000410	sequence specific DNA binding site [nucleotide binding]; other site
320389000411	putative cAMP binding site [chemical binding]; other site
320389000412	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
320389000413	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
320389000414	NAD(P) binding site [chemical binding]; other site
320389000415	homotetramer interface [polypeptide binding]; other site
320389000416	homodimer interface [polypeptide binding]; other site
320389000417	active site
320389000418	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
320389000419	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
320389000420	Beta-Casp domain; Region: Beta-Casp; smart01027
320389000421	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
320389000422	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
320389000423	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
320389000424	Transposase domain (DUF772); Region: DUF772; pfam05598
320389000425	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389000426	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389000427	lysine transporter; Provisional; Region: PRK10836
320389000428	HTH-like domain; Region: HTH_21; pfam13276
320389000429	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000430	Integrase core domain; Region: rve; pfam00665
320389000431	Integrase core domain; Region: rve_3; pfam13683
320389000432	Transposase; Region: HTH_Tnp_1; pfam01527
320389000433	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
320389000434	Asp-box motif; other site
320389000435	Isochorismatase family; Region: Isochorismatase; pfam00857
320389000436	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
320389000437	catalytic triad [active]
320389000438	conserved cis-peptide bond; other site
320389000439	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389000440	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
320389000441	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
320389000442	putative NAD(P) binding site [chemical binding]; other site
320389000443	active site
320389000444	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
320389000445	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389000446	catalytic loop [active]
320389000447	iron binding site [ion binding]; other site
320389000448	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
320389000449	FAD binding pocket [chemical binding]; other site
320389000450	FAD binding motif [chemical binding]; other site
320389000451	phosphate binding motif [ion binding]; other site
320389000452	beta-alpha-beta structure motif; other site
320389000453	NAD binding pocket [chemical binding]; other site
320389000454	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
320389000455	inter-subunit interface; other site
320389000456	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
320389000457	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
320389000458	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
320389000459	putative alpha subunit interface [polypeptide binding]; other site
320389000460	putative active site [active]
320389000461	putative substrate binding site [chemical binding]; other site
320389000462	Fe binding site [ion binding]; other site
320389000463	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389000464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000465	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
320389000466	dimerizarion interface [polypeptide binding]; other site
320389000467	CrgA pocket; other site
320389000468	substrate binding pocket [chemical binding]; other site
320389000469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389000470	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389000471	NAD(P) binding site [chemical binding]; other site
320389000472	active site
320389000473	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
320389000474	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389000475	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389000476	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
320389000477	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
320389000478	active site
320389000479	FMN binding site [chemical binding]; other site
320389000480	2,4-decadienoyl-CoA binding site; other site
320389000481	catalytic residue [active]
320389000482	4Fe-4S cluster binding site [ion binding]; other site
320389000483	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
320389000484	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389000485	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
320389000486	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
320389000487	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
320389000488	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
320389000489	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
320389000490	D-pathway; other site
320389000491	Putative ubiquinol binding site [chemical binding]; other site
320389000492	Low-spin heme (heme b) binding site [chemical binding]; other site
320389000493	Putative water exit pathway; other site
320389000494	Binuclear center (heme o3/CuB) [ion binding]; other site
320389000495	K-pathway; other site
320389000496	Putative proton exit pathway; other site
320389000497	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
320389000498	Subunit I/III interface [polypeptide binding]; other site
320389000499	Subunit III/IV interface [polypeptide binding]; other site
320389000500	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
320389000501	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
320389000502	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
320389000503	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
320389000504	dimer interface [polypeptide binding]; other site
320389000505	active site
320389000506	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
320389000507	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
320389000508	octamer interface [polypeptide binding]; other site
320389000509	active site
320389000510	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
320389000511	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000512	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389000513	dimerization interface [polypeptide binding]; other site
320389000514	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389000515	Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545
320389000516	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
320389000517	putative alpha subunit interface [polypeptide binding]; other site
320389000518	putative active site [active]
320389000519	putative substrate binding site [chemical binding]; other site
320389000520	Fe binding site [ion binding]; other site
320389000521	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
320389000522	inter-subunit interface; other site
320389000523	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
320389000524	[2Fe-2S] cluster binding site [ion binding]; other site
320389000525	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
320389000526	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389000527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389000528	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
320389000529	HIT family signature motif; other site
320389000530	catalytic residue [active]
320389000531	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
320389000532	PLD-like domain; Region: PLDc_2; pfam13091
320389000533	putative active site [active]
320389000534	catalytic site [active]
320389000535	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
320389000536	PLD-like domain; Region: PLDc_2; pfam13091
320389000537	putative active site [active]
320389000538	catalytic site [active]
320389000539	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
320389000540	acetolactate synthase; Reviewed; Region: PRK08322
320389000541	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
320389000542	PYR/PP interface [polypeptide binding]; other site
320389000543	dimer interface [polypeptide binding]; other site
320389000544	TPP binding site [chemical binding]; other site
320389000545	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389000546	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
320389000547	TPP-binding site [chemical binding]; other site
320389000548	dimer interface [polypeptide binding]; other site
320389000549	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
320389000550	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389000551	NAD(P) binding site [chemical binding]; other site
320389000552	catalytic residues [active]
320389000553	Response regulator receiver domain; Region: Response_reg; pfam00072
320389000554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389000555	active site
320389000556	phosphorylation site [posttranslational modification]
320389000557	intermolecular recognition site; other site
320389000558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389000559	dimerization interface [polypeptide binding]; other site
320389000560	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389000561	dimer interface [polypeptide binding]; other site
320389000562	phosphorylation site [posttranslational modification]
320389000563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389000564	ATP binding site [chemical binding]; other site
320389000565	Mg2+ binding site [ion binding]; other site
320389000566	G-X-G motif; other site
320389000567	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
320389000568	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
320389000569	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389000570	dimerization interface [polypeptide binding]; other site
320389000571	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389000572	dimer interface [polypeptide binding]; other site
320389000573	putative CheW interface [polypeptide binding]; other site
320389000574	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
320389000575	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
320389000576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389000577	S-adenosylmethionine binding site [chemical binding]; other site
320389000578	TPR repeat; Region: TPR_11; pfam13414
320389000579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389000580	binding surface
320389000581	TPR motif; other site
320389000582	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
320389000583	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
320389000584	putative binding surface; other site
320389000585	active site
320389000586	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
320389000587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389000588	ATP binding site [chemical binding]; other site
320389000589	Mg2+ binding site [ion binding]; other site
320389000590	G-X-G motif; other site
320389000591	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
320389000592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389000593	Response regulator receiver domain; Region: Response_reg; pfam00072
320389000594	active site
320389000595	phosphorylation site [posttranslational modification]
320389000596	intermolecular recognition site; other site
320389000597	dimerization interface [polypeptide binding]; other site
320389000598	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
320389000599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389000600	active site
320389000601	phosphorylation site [posttranslational modification]
320389000602	intermolecular recognition site; other site
320389000603	CheB methylesterase; Region: CheB_methylest; pfam01339
320389000604	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
320389000605	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389000606	motif II; other site
320389000607	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
320389000608	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
320389000609	Cl- selectivity filter; other site
320389000610	Cl- binding residues [ion binding]; other site
320389000611	pore gating glutamate residue; other site
320389000612	dimer interface [polypeptide binding]; other site
320389000613	CAAX protease self-immunity; Region: Abi; pfam02517
320389000614	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
320389000615	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
320389000616	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
320389000617	active site
320389000618	HIGH motif; other site
320389000619	dimer interface [polypeptide binding]; other site
320389000620	KMSKS motif; other site
320389000621	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
320389000622	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
320389000623	conserved cys residue [active]
320389000624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389000625	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
320389000626	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
320389000627	conserved cys residue [active]
320389000628	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
320389000629	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
320389000630	Walker A/P-loop; other site
320389000631	ATP binding site [chemical binding]; other site
320389000632	Q-loop/lid; other site
320389000633	ABC transporter signature motif; other site
320389000634	Walker B; other site
320389000635	D-loop; other site
320389000636	H-loop/switch region; other site
320389000637	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
320389000638	Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413
320389000639	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
320389000640	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
320389000641	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389000642	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389000643	active site
320389000644	Phosphotransferase enzyme family; Region: APH; pfam01636
320389000645	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
320389000646	putative active site [active]
320389000647	putative substrate binding site [chemical binding]; other site
320389000648	ATP binding site [chemical binding]; other site
320389000649	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
320389000650	catalytic core [active]
320389000651	short chain dehydrogenase; Provisional; Region: PRK07035
320389000652	classical (c) SDRs; Region: SDR_c; cd05233
320389000653	NAD(P) binding site [chemical binding]; other site
320389000654	active site
320389000655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389000656	short chain dehydrogenase; Validated; Region: PRK07069
320389000657	NAD(P) binding site [chemical binding]; other site
320389000658	active site
320389000659	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
320389000660	Prostaglandin dehydrogenases; Region: PGDH; cd05288
320389000661	NAD(P) binding site [chemical binding]; other site
320389000662	substrate binding site [chemical binding]; other site
320389000663	dimer interface [polypeptide binding]; other site
320389000664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000665	putative substrate translocation pore; other site
320389000666	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389000667	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
320389000668	N-terminal plug; other site
320389000669	ligand-binding site [chemical binding]; other site
320389000670	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
320389000671	Domain of unknown function DUF20; Region: UPF0118; pfam01594
320389000672	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
320389000673	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
320389000674	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
320389000675	generic binding surface I; other site
320389000676	generic binding surface II; other site
320389000677	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
320389000678	putative active site [active]
320389000679	putative catalytic site [active]
320389000680	putative Mg binding site IVb [ion binding]; other site
320389000681	putative phosphate binding site [ion binding]; other site
320389000682	putative DNA binding site [nucleotide binding]; other site
320389000683	putative Mg binding site IVa [ion binding]; other site
320389000684	YCII-related domain; Region: YCII; cl00999
320389000685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
320389000686	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
320389000687	putative hydrophobic ligand binding site [chemical binding]; other site
320389000688	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
320389000689	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389000690	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
320389000691	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
320389000692	amidase catalytic site [active]
320389000693	Zn binding residues [ion binding]; other site
320389000694	substrate binding site [chemical binding]; other site
320389000695	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
320389000696	Rubrerythrin [Energy production and conversion]; Region: COG1592
320389000697	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
320389000698	binuclear metal center [ion binding]; other site
320389000699	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
320389000700	Cysteine-rich domain; Region: CCG; pfam02754
320389000701	Cysteine-rich domain; Region: CCG; pfam02754
320389000702	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
320389000703	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
320389000704	CoA-binding domain; Region: CoA_binding_3; pfam13727
320389000705	Bacterial sugar transferase; Region: Bac_transf; cl00939
320389000706	Transposase; Region: HTH_Tnp_1; pfam01527
320389000707	HTH-like domain; Region: HTH_21; pfam13276
320389000708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000709	Integrase core domain; Region: rve; pfam00665
320389000710	Integrase core domain; Region: rve_3; pfam13683
320389000711	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389000712	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389000713	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389000714	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389000715	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389000716	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
320389000717	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
320389000718	phosphate binding site [ion binding]; other site
320389000719	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
320389000720	putative deacylase active site [active]
320389000721	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
320389000722	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
320389000723	active site
320389000724	catalytic site [active]
320389000725	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
320389000726	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
320389000727	thiamine phosphate binding site [chemical binding]; other site
320389000728	active site
320389000729	pyrophosphate binding site [ion binding]; other site
320389000730	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
320389000731	Domain of unknown function DUF21; Region: DUF21; pfam01595
320389000732	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
320389000733	Transporter associated domain; Region: CorC_HlyC; smart01091
320389000734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389000735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389000736	dimer interface [polypeptide binding]; other site
320389000737	phosphorylation site [posttranslational modification]
320389000738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
320389000739	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
320389000740	EamA-like transporter family; Region: EamA; pfam00892
320389000741	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389000742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000743	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389000744	dimerization interface [polypeptide binding]; other site
320389000745	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
320389000746	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
320389000747	dimer interface [polypeptide binding]; other site
320389000748	hexamer interface [polypeptide binding]; other site
320389000749	active site 2 [active]
320389000750	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
320389000751	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
320389000752	molybdenum-pterin binding domain; Region: Mop; TIGR00638
320389000753	TOBE domain; Region: TOBE; cl01440
320389000754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389000755	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
320389000756	Walker A/P-loop; other site
320389000757	ATP binding site [chemical binding]; other site
320389000758	Q-loop/lid; other site
320389000759	ABC transporter signature motif; other site
320389000760	Walker B; other site
320389000761	D-loop; other site
320389000762	H-loop/switch region; other site
320389000763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389000764	putative PBP binding loops; other site
320389000765	dimer interface [polypeptide binding]; other site
320389000766	ABC-ATPase subunit interface; other site
320389000767	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
320389000768	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
320389000769	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
320389000770	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
320389000771	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
320389000772	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389000773	MarR family; Region: MarR; pfam01047
320389000774	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
320389000775	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
320389000776	putative active site [active]
320389000777	putative substrate binding site [chemical binding]; other site
320389000778	ATP binding site [chemical binding]; other site
320389000779	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
320389000780	AMP nucleosidase; Provisional; Region: PRK08292
320389000781	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
320389000782	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
320389000783	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
320389000784	active site
320389000785	Int/Topo IB signature motif; other site
320389000786	DNA binding site [nucleotide binding]
320389000787	HTH-like domain; Region: HTH_21; pfam13276
320389000788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000789	Integrase core domain; Region: rve; pfam00665
320389000790	Integrase core domain; Region: rve_3; pfam13683
320389000791	Transposase; Region: HTH_Tnp_1; pfam01527
320389000792	Uncharacterized conserved protein [Function unknown]; Region: COG1683
320389000793	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
320389000794	DNA polymerase I; Provisional; Region: PRK05755
320389000795	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
320389000796	active site
320389000797	metal binding site 1 [ion binding]; metal-binding site
320389000798	putative 5' ssDNA interaction site; other site
320389000799	metal binding site 3; metal-binding site
320389000800	metal binding site 2 [ion binding]; metal-binding site
320389000801	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
320389000802	putative DNA binding site [nucleotide binding]; other site
320389000803	putative metal binding site [ion binding]; other site
320389000804	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
320389000805	active site
320389000806	catalytic site [active]
320389000807	substrate binding site [chemical binding]; other site
320389000808	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
320389000809	active site
320389000810	DNA binding site [nucleotide binding]
320389000811	catalytic site [active]
320389000812	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
320389000813	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389000814	Predicted membrane protein [Function unknown]; Region: COG4655
320389000815	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
320389000816	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
320389000817	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
320389000818	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
320389000819	active site residue [active]
320389000820	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
320389000821	active site residue [active]
320389000822	Transposase domain (DUF772); Region: DUF772; pfam05598
320389000823	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389000824	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389000825	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
320389000826	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
320389000827	[2Fe-2S] cluster binding site [ion binding]; other site
320389000828	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
320389000829	alpha subunit interface [polypeptide binding]; other site
320389000830	active site
320389000831	substrate binding site [chemical binding]; other site
320389000832	Fe binding site [ion binding]; other site
320389000833	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
320389000834	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
320389000835	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
320389000836	substrate binding pocket [chemical binding]; other site
320389000837	chain length determination region; other site
320389000838	substrate-Mg2+ binding site; other site
320389000839	catalytic residues [active]
320389000840	aspartate-rich region 1; other site
320389000841	active site lid residues [active]
320389000842	aspartate-rich region 2; other site
320389000843	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
320389000844	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
320389000845	TPP-binding site; other site
320389000846	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
320389000847	PYR/PP interface [polypeptide binding]; other site
320389000848	dimer interface [polypeptide binding]; other site
320389000849	TPP binding site [chemical binding]; other site
320389000850	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
320389000851	putative GTP cyclohydrolase; Provisional; Region: PRK13674
320389000852	UGMP family protein; Validated; Region: PRK09604
320389000853	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
320389000854	Predicted flavoproteins [General function prediction only]; Region: COG2081
320389000855	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
320389000856	Yqey-like protein; Region: YqeY; pfam09424
320389000857	DNA primase; Validated; Region: dnaG; PRK05667
320389000858	CHC2 zinc finger; Region: zf-CHC2; pfam01807
320389000859	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
320389000860	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
320389000861	active site
320389000862	metal binding site [ion binding]; metal-binding site
320389000863	interdomain interaction site; other site
320389000864	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
320389000865	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
320389000866	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
320389000867	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
320389000868	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
320389000869	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
320389000870	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389000871	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
320389000872	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389000873	DNA binding residues [nucleotide binding]
320389000874	HTH-like domain; Region: HTH_21; pfam13276
320389000875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389000876	Integrase core domain; Region: rve; pfam00665
320389000877	Integrase core domain; Region: rve_3; pfam13683
320389000878	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
320389000879	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000880	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
320389000881	substrate binding pocket [chemical binding]; other site
320389000882	dimerization interface [polypeptide binding]; other site
320389000883	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
320389000884	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
320389000885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000886	putative substrate translocation pore; other site
320389000887	POT family; Region: PTR2; cl17359
320389000888	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
320389000889	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389000890	non-specific DNA binding site [nucleotide binding]; other site
320389000891	salt bridge; other site
320389000892	sequence-specific DNA binding site [nucleotide binding]; other site
320389000893	Cupin domain; Region: Cupin_2; pfam07883
320389000894	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
320389000895	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
320389000896	peptide binding site [polypeptide binding]; other site
320389000897	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
320389000898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389000899	dimer interface [polypeptide binding]; other site
320389000900	conserved gate region; other site
320389000901	putative PBP binding loops; other site
320389000902	ABC-ATPase subunit interface; other site
320389000903	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
320389000904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389000905	dimer interface [polypeptide binding]; other site
320389000906	conserved gate region; other site
320389000907	putative PBP binding loops; other site
320389000908	ABC-ATPase subunit interface; other site
320389000909	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
320389000910	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389000911	Walker A/P-loop; other site
320389000912	ATP binding site [chemical binding]; other site
320389000913	Q-loop/lid; other site
320389000914	ABC transporter signature motif; other site
320389000915	Walker B; other site
320389000916	D-loop; other site
320389000917	H-loop/switch region; other site
320389000918	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389000919	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
320389000920	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389000921	Walker A/P-loop; other site
320389000922	ATP binding site [chemical binding]; other site
320389000923	Q-loop/lid; other site
320389000924	ABC transporter signature motif; other site
320389000925	Walker B; other site
320389000926	D-loop; other site
320389000927	H-loop/switch region; other site
320389000928	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389000929	outer membrane porin, OprD family; Region: OprD; pfam03573
320389000930	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
320389000931	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
320389000932	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
320389000933	active site residue [active]
320389000934	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
320389000935	PAS fold; Region: PAS_4; pfam08448
320389000936	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389000937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389000938	Walker B motif; other site
320389000939	arginine finger; other site
320389000940	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389000941	H-NS histone family; Region: Histone_HNS; pfam00816
320389000942	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389000943	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
320389000944	CoA binding domain; Region: CoA_binding_2; pfam13380
320389000945	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
320389000946	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
320389000947	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
320389000948	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389000949	Coenzyme A binding pocket [chemical binding]; other site
320389000950	indole acetimide hydrolase; Validated; Region: PRK07488
320389000951	Amidase; Region: Amidase; pfam01425
320389000952	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389000953	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
320389000954	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389000955	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
320389000956	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
320389000957	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
320389000958	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
320389000959	phosphate binding site [ion binding]; other site
320389000960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000961	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389000962	dimerization interface [polypeptide binding]; other site
320389000963	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389000964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000965	putative substrate translocation pore; other site
320389000966	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
320389000967	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
320389000968	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389000969	catalytic residue [active]
320389000970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389000971	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389000972	putative substrate translocation pore; other site
320389000973	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
320389000974	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389000975	dimerization interface [polypeptide binding]; other site
320389000976	putative DNA binding site [nucleotide binding]; other site
320389000977	putative Zn2+ binding site [ion binding]; other site
320389000978	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
320389000979	active site residue [active]
320389000980	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
320389000981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000982	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389000983	dimerization interface [polypeptide binding]; other site
320389000984	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
320389000985	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389000986	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
320389000987	dimerization interface [polypeptide binding]; other site
320389000988	substrate binding pocket [chemical binding]; other site
320389000989	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
320389000990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389000991	NAD(P) binding site [chemical binding]; other site
320389000992	active site
320389000993	hypothetical protein; Provisional; Region: PRK07538
320389000994	hypothetical protein; Provisional; Region: PRK07236
320389000995	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
320389000996	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
320389000997	phosphopeptide binding site; other site
320389000998	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
320389000999	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
320389001000	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
320389001001	hypothetical protein; Provisional; Region: PRK07033
320389001002	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
320389001003	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389001004	ligand binding site [chemical binding]; other site
320389001005	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
320389001006	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
320389001007	G1 box; other site
320389001008	GTP/Mg2+ binding site [chemical binding]; other site
320389001009	G2 box; other site
320389001010	G3 box; other site
320389001011	Switch II region; other site
320389001012	G4 box; other site
320389001013	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
320389001014	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
320389001015	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
320389001016	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
320389001017	Catalytic domain of Protein Kinases; Region: PKc; cd00180
320389001018	active site
320389001019	ATP binding site [chemical binding]; other site
320389001020	substrate binding site [chemical binding]; other site
320389001021	activation loop (A-loop); other site
320389001022	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
320389001023	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
320389001024	Protein of unknown function (DUF770); Region: DUF770; pfam05591
320389001025	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
320389001026	Protein of unknown function (DUF877); Region: DUF877; pfam05943
320389001027	Protein of unknown function (DUF796); Region: DUF796; pfam05638
320389001028	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
320389001029	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
320389001030	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
320389001031	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
320389001032	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
320389001033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389001034	Walker A motif; other site
320389001035	ATP binding site [chemical binding]; other site
320389001036	Walker B motif; other site
320389001037	arginine finger; other site
320389001038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389001039	Walker A motif; other site
320389001040	ATP binding site [chemical binding]; other site
320389001041	Walker B motif; other site
320389001042	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
320389001043	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
320389001044	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389001045	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389001046	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
320389001047	RHS Repeat; Region: RHS_repeat; cl11982
320389001048	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
320389001049	RHS Repeat; Region: RHS_repeat; cl11982
320389001050	RHS Repeat; Region: RHS_repeat; cl11982
320389001051	RHS Repeat; Region: RHS_repeat; cl11982
320389001052	RHS Repeat; Region: RHS_repeat; cl11982
320389001053	HTH-like domain; Region: HTH_21; pfam13276
320389001054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001055	Integrase core domain; Region: rve; pfam00665
320389001056	Integrase core domain; Region: rve_3; pfam13683
320389001057	Transposase; Region: HTH_Tnp_1; pfam01527
320389001058	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
320389001059	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
320389001060	NAD-dependent deacetylase; Provisional; Region: PRK05333
320389001061	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
320389001062	Protein of unknown function (DUF938); Region: DUF938; pfam06080
320389001063	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
320389001064	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
320389001065	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
320389001066	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389001067	Cupin domain; Region: Cupin_2; cl17218
320389001068	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
320389001069	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
320389001070	E3 interaction surface; other site
320389001071	lipoyl attachment site [posttranslational modification]; other site
320389001072	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
320389001073	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
320389001074	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
320389001075	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389001076	N-terminal plug; other site
320389001077	ligand-binding site [chemical binding]; other site
320389001078	lipase chaperone; Provisional; Region: PRK01294
320389001079	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
320389001080	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389001081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389001082	DNA-binding site [nucleotide binding]; DNA binding site
320389001083	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389001084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001085	homodimer interface [polypeptide binding]; other site
320389001086	catalytic residue [active]
320389001087	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
320389001088	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389001089	Walker A/P-loop; other site
320389001090	ATP binding site [chemical binding]; other site
320389001091	Q-loop/lid; other site
320389001092	ABC transporter signature motif; other site
320389001093	Walker B; other site
320389001094	D-loop; other site
320389001095	H-loop/switch region; other site
320389001096	TOBE domain; Region: TOBE_2; pfam08402
320389001097	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
320389001098	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
320389001099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389001100	dimer interface [polypeptide binding]; other site
320389001101	conserved gate region; other site
320389001102	putative PBP binding loops; other site
320389001103	ABC-ATPase subunit interface; other site
320389001104	HTH-like domain; Region: HTH_21; pfam13276
320389001105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001106	Integrase core domain; Region: rve; pfam00665
320389001107	Integrase core domain; Region: rve_3; pfam13683
320389001108	Transposase; Region: HTH_Tnp_1; pfam01527
320389001109	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
320389001110	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
320389001111	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
320389001112	haemagglutination activity domain; Region: Haemagg_act; pfam05860
320389001113	Inositol polyphosphate kinase; Region: IPK; cl12283
320389001114	aconitate hydratase; Provisional; Region: acnA; PRK12881
320389001115	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
320389001116	substrate binding site [chemical binding]; other site
320389001117	ligand binding site [chemical binding]; other site
320389001118	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
320389001119	substrate binding site [chemical binding]; other site
320389001120	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
320389001121	2-methylcitrate dehydratase; Region: prpD; TIGR02330
320389001122	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
320389001123	malate dehydrogenase; Provisional; Region: PRK05442
320389001124	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
320389001125	NAD(P) binding site [chemical binding]; other site
320389001126	dimer interface [polypeptide binding]; other site
320389001127	malate binding site [chemical binding]; other site
320389001128	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
320389001129	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389001130	DNA-binding site [nucleotide binding]; DNA binding site
320389001131	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
320389001132	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
320389001133	proximal quinone binding site [chemical binding]; other site
320389001134	SdhD (CybS) interface [polypeptide binding]; other site
320389001135	proximal heme binding site [chemical binding]; other site
320389001136	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
320389001137	SdhC subunit interface [polypeptide binding]; other site
320389001138	proximal heme binding site [chemical binding]; other site
320389001139	cardiolipin binding site; other site
320389001140	Iron-sulfur protein interface; other site
320389001141	proximal quinone binding site [chemical binding]; other site
320389001142	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
320389001143	L-aspartate oxidase; Provisional; Region: PRK06175
320389001144	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
320389001145	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
320389001146	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
320389001147	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
320389001148	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
320389001149	dimer interface [polypeptide binding]; other site
320389001150	active site
320389001151	citrylCoA binding site [chemical binding]; other site
320389001152	NADH binding [chemical binding]; other site
320389001153	cationic pore residues; other site
320389001154	oxalacetate/citrate binding site [chemical binding]; other site
320389001155	coenzyme A binding site [chemical binding]; other site
320389001156	catalytic triad [active]
320389001157	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389001158	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389001159	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
320389001160	HTH-like domain; Region: HTH_21; pfam13276
320389001161	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001162	Integrase core domain; Region: rve; pfam00665
320389001163	Integrase core domain; Region: rve_3; pfam13683
320389001164	Transposase; Region: HTH_Tnp_1; pfam01527
320389001165	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
320389001166	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
320389001167	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
320389001168	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
320389001169	dimer interface [polypeptide binding]; other site
320389001170	TPP-binding site [chemical binding]; other site
320389001171	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
320389001172	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389001173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389001174	putative DNA binding site [nucleotide binding]; other site
320389001175	putative Zn2+ binding site [ion binding]; other site
320389001176	AsnC family; Region: AsnC_trans_reg; pfam01037
320389001177	cyclase homology domain; Region: CHD; cd07302
320389001178	nucleotidyl binding site; other site
320389001179	metal binding site [ion binding]; metal-binding site
320389001180	dimer interface [polypeptide binding]; other site
320389001181	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
320389001182	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
320389001183	active site
320389001184	non-prolyl cis peptide bond; other site
320389001185	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
320389001186	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
320389001187	substrate binding site [chemical binding]; other site
320389001188	ligand binding site [chemical binding]; other site
320389001189	Predicted small secreted protein [Function unknown]; Region: COG5510
320389001190	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
320389001191	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
320389001192	substrate binding site [chemical binding]; other site
320389001193	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
320389001194	tartrate dehydrogenase; Region: TTC; TIGR02089
320389001195	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
320389001196	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
320389001197	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
320389001198	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
320389001199	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
320389001200	dimerization interface 3.5A [polypeptide binding]; other site
320389001201	active site
320389001202	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
320389001203	active site
320389001204	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
320389001205	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
320389001206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001207	catalytic residue [active]
320389001208	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
320389001209	DNA methylase; Region: N6_N4_Mtase; pfam01555
320389001210	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
320389001211	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
320389001212	substrate binding site [chemical binding]; other site
320389001213	active site
320389001214	catalytic residues [active]
320389001215	heterodimer interface [polypeptide binding]; other site
320389001216	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
320389001217	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
320389001218	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
320389001219	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
320389001220	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
320389001221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
320389001222	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
320389001223	Colicin V production protein; Region: Colicin_V; pfam02674
320389001224	amidophosphoribosyltransferase; Provisional; Region: PRK09246
320389001225	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
320389001226	active site
320389001227	tetramer interface [polypeptide binding]; other site
320389001228	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389001229	active site
320389001230	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
320389001231	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
320389001232	homodimer interface [polypeptide binding]; other site
320389001233	substrate-cofactor binding pocket; other site
320389001234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001235	catalytic residue [active]
320389001236	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
320389001237	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
320389001238	NADP-binding site; other site
320389001239	homotetramer interface [polypeptide binding]; other site
320389001240	substrate binding site [chemical binding]; other site
320389001241	homodimer interface [polypeptide binding]; other site
320389001242	active site
320389001243	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
320389001244	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
320389001245	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
320389001246	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
320389001247	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389001248	putative ADP-binding pocket [chemical binding]; other site
320389001249	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
320389001250	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389001251	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
320389001252	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
320389001253	active site
320389001254	tetramer interface; other site
320389001255	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
320389001256	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389001257	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389001258	trimer interface [polypeptide binding]; other site
320389001259	eyelet of channel; other site
320389001260	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
320389001261	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
320389001262	putative active site [active]
320389001263	Zn binding site [ion binding]; other site
320389001264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389001265	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389001266	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389001267	substrate binding pocket [chemical binding]; other site
320389001268	membrane-bound complex binding site; other site
320389001269	hinge residues; other site
320389001270	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
320389001271	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
320389001272	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
320389001273	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
320389001274	active site
320389001275	non-prolyl cis peptide bond; other site
320389001276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389001277	dimer interface [polypeptide binding]; other site
320389001278	conserved gate region; other site
320389001279	putative PBP binding loops; other site
320389001280	ABC-ATPase subunit interface; other site
320389001281	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
320389001282	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389001283	Walker A/P-loop; other site
320389001284	ATP binding site [chemical binding]; other site
320389001285	Q-loop/lid; other site
320389001286	ABC transporter signature motif; other site
320389001287	Walker B; other site
320389001288	D-loop; other site
320389001289	H-loop/switch region; other site
320389001290	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389001291	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389001292	substrate binding pocket [chemical binding]; other site
320389001293	membrane-bound complex binding site; other site
320389001294	hinge residues; other site
320389001295	Uncharacterized conserved protein [Function unknown]; Region: COG1434
320389001296	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
320389001297	putative active site [active]
320389001298	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
320389001299	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
320389001300	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
320389001301	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
320389001302	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
320389001303	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
320389001304	selenocysteine synthase; Provisional; Region: PRK04311
320389001305	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
320389001306	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389001307	catalytic residue [active]
320389001308	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
320389001309	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
320389001310	G1 box; other site
320389001311	putative GEF interaction site [polypeptide binding]; other site
320389001312	GTP/Mg2+ binding site [chemical binding]; other site
320389001313	Switch I region; other site
320389001314	G2 box; other site
320389001315	G3 box; other site
320389001316	Switch II region; other site
320389001317	G4 box; other site
320389001318	G5 box; other site
320389001319	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
320389001320	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
320389001321	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
320389001322	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
320389001323	H+ Antiporter protein; Region: 2A0121; TIGR00900
320389001324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001325	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
320389001326	Cytochrome P450; Region: p450; cl12078
320389001327	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
320389001328	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
320389001329	FMN-binding pocket [chemical binding]; other site
320389001330	flavin binding motif; other site
320389001331	phosphate binding motif [ion binding]; other site
320389001332	beta-alpha-beta structure motif; other site
320389001333	NAD binding pocket [chemical binding]; other site
320389001334	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389001335	catalytic loop [active]
320389001336	iron binding site [ion binding]; other site
320389001337	benzoate transport; Region: 2A0115; TIGR00895
320389001338	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
320389001339	active site
320389001340	nucleophile elbow; other site
320389001341	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
320389001342	Cu(I) binding site [ion binding]; other site
320389001343	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
320389001344	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
320389001345	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
320389001346	putative sugar binding sites [chemical binding]; other site
320389001347	Q-X-W motif; other site
320389001348	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
320389001349	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
320389001350	putative sugar binding sites [chemical binding]; other site
320389001351	Q-X-W motif; other site
320389001352	Kelch motif; Region: Kelch_6; pfam13964
320389001353	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
320389001354	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
320389001355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389001356	active site
320389001357	phosphorylation site [posttranslational modification]
320389001358	intermolecular recognition site; other site
320389001359	dimerization interface [polypeptide binding]; other site
320389001360	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
320389001361	Zn2+ binding site [ion binding]; other site
320389001362	Mg2+ binding site [ion binding]; other site
320389001363	Uncharacterized conserved protein [Function unknown]; Region: COG3287
320389001364	FIST N domain; Region: FIST; pfam08495
320389001365	FIST C domain; Region: FIST_C; pfam10442
320389001366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389001367	ATP binding site [chemical binding]; other site
320389001368	Mg2+ binding site [ion binding]; other site
320389001369	G-X-G motif; other site
320389001370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
320389001371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001372	putative substrate translocation pore; other site
320389001373	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389001374	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001375	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389001376	putative effector binding pocket; other site
320389001377	dimerization interface [polypeptide binding]; other site
320389001378	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389001379	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001380	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
320389001381	putative dimerization interface [polypeptide binding]; other site
320389001382	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
320389001383	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
320389001384	putative active site [active]
320389001385	putative catalytic site [active]
320389001386	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
320389001387	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
320389001388	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
320389001389	pyruvate dehydrogenase; Provisional; Region: PRK09124
320389001390	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
320389001391	PYR/PP interface [polypeptide binding]; other site
320389001392	tetramer interface [polypeptide binding]; other site
320389001393	dimer interface [polypeptide binding]; other site
320389001394	TPP binding site [chemical binding]; other site
320389001395	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389001396	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
320389001397	TPP-binding site [chemical binding]; other site
320389001398	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
320389001399	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389001400	inhibitor-cofactor binding pocket; inhibition site
320389001401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001402	catalytic residue [active]
320389001403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001404	putative substrate translocation pore; other site
320389001405	Condensation domain; Region: Condensation; pfam00668
320389001406	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
320389001407	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389001408	acyl-activating enzyme (AAE) consensus motif; other site
320389001409	AMP binding site [chemical binding]; other site
320389001410	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389001411	Condensation domain; Region: Condensation; pfam00668
320389001412	Transposase; Region: HTH_Tnp_1; pfam01527
320389001413	HTH-like domain; Region: HTH_21; pfam13276
320389001414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001415	Integrase core domain; Region: rve; pfam00665
320389001416	Integrase core domain; Region: rve_3; pfam13683
320389001417	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
320389001418	substrate binding pocket [chemical binding]; other site
320389001419	active site
320389001420	iron coordination sites [ion binding]; other site
320389001421	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
320389001422	type III secretion protein HrpB7; Region: HrpB7; TIGR02559
320389001423	type III secretion system ATPase; Provisional; Region: PRK09099
320389001424	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
320389001425	Walker A motif; other site
320389001426	ATP binding site [chemical binding]; other site
320389001427	Walker B motif; other site
320389001428	type III secretion system protein HrpB; Validated; Region: PRK09098
320389001429	Flagellar assembly protein FliH; Region: FliH; pfam02108
320389001430	type III secretion protein HrpB4; Region: HrpB4; TIGR02560
320389001431	Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502
320389001432	type III secretion protein HrpB2; Region: HrpB2; TIGR02558
320389001433	type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561
320389001434	type III secretion system protein HrcU; Validated; Region: PRK09108
320389001435	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
320389001436	type III secretion protein, HrcV family; Region: hrcV; TIGR01399
320389001437	FHIPEP family; Region: FHIPEP; pfam00771
320389001438	Type III secretion protein (HpaP); Region: HpaP; cl17849
320389001439	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
320389001440	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
320389001441	type III secretion system protein YscR; Provisional; Region: PRK12797
320389001442	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
320389001443	Tir chaperone protein (CesT) family; Region: CesT; cl08444
320389001444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389001445	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389001446	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
320389001447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389001448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389001449	ATP binding site [chemical binding]; other site
320389001450	Mg2+ binding site [ion binding]; other site
320389001451	G-X-G motif; other site
320389001452	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389001453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389001454	active site
320389001455	phosphorylation site [posttranslational modification]
320389001456	intermolecular recognition site; other site
320389001457	dimerization interface [polypeptide binding]; other site
320389001458	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389001459	DNA binding site [nucleotide binding]
320389001460	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
320389001461	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
320389001462	Walker A motif; other site
320389001463	ATP binding site [chemical binding]; other site
320389001464	Walker B motif; other site
320389001465	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
320389001466	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
320389001467	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389001468	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
320389001469	Type II/IV secretion system protein; Region: T2SE; pfam00437
320389001470	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
320389001471	Walker A motif; other site
320389001472	ATP binding site [chemical binding]; other site
320389001473	Walker B motif; other site
320389001474	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389001475	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389001476	PilS N terminal; Region: PilS; pfam08805
320389001477	PilM; Region: PilM; pfam07419
320389001478	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
320389001479	type II secretion system protein D; Region: type_II_gspD; TIGR02517
320389001480	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389001481	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389001482	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389001483	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
320389001484	agmatinase; Region: agmatinase; TIGR01230
320389001485	oligomer interface [polypeptide binding]; other site
320389001486	putative active site [active]
320389001487	Mn binding site [ion binding]; other site
320389001488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389001489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001490	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389001491	dimerization interface [polypeptide binding]; other site
320389001492	HipA N-terminal domain; Region: couple_hipA; TIGR03071
320389001493	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
320389001494	HipA-like N-terminal domain; Region: HipA_N; pfam07805
320389001495	HipA-like C-terminal domain; Region: HipA_C; pfam07804
320389001496	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389001497	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
320389001498	non-specific DNA binding site [nucleotide binding]; other site
320389001499	salt bridge; other site
320389001500	sequence-specific DNA binding site [nucleotide binding]; other site
320389001501	cellulose synthase regulator protein; Provisional; Region: PRK11114
320389001502	endo-1,4-D-glucanase; Provisional; Region: PRK11097
320389001503	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
320389001504	cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369
320389001505	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
320389001506	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
320389001507	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
320389001508	DXD motif; other site
320389001509	PilZ domain; Region: PilZ; pfam07238
320389001510	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
320389001511	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
320389001512	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
320389001513	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389001514	membrane-bound complex binding site; other site
320389001515	hinge residues; other site
320389001516	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
320389001517	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
320389001518	Walker A/P-loop; other site
320389001519	ATP binding site [chemical binding]; other site
320389001520	Q-loop/lid; other site
320389001521	ABC transporter signature motif; other site
320389001522	Walker B; other site
320389001523	D-loop; other site
320389001524	H-loop/switch region; other site
320389001525	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
320389001526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389001527	dimer interface [polypeptide binding]; other site
320389001528	conserved gate region; other site
320389001529	putative PBP binding loops; other site
320389001530	ABC-ATPase subunit interface; other site
320389001531	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
320389001532	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
320389001533	putative active site [active]
320389001534	putative FMN binding site [chemical binding]; other site
320389001535	putative substrate binding site [chemical binding]; other site
320389001536	putative catalytic residue [active]
320389001537	Autoinducer synthetase; Region: Autoind_synth; cl17404
320389001538	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389001539	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389001540	DNA binding residues [nucleotide binding]
320389001541	dimerization interface [polypeptide binding]; other site
320389001542	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
320389001543	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389001544	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
320389001545	putative AMP binding site [chemical binding]; other site
320389001546	putative active site [active]
320389001547	acyl-activating enzyme (AAE) consensus motif; other site
320389001548	putative CoA binding site [chemical binding]; other site
320389001549	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
320389001550	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
320389001551	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
320389001552	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389001553	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389001554	putative DNA binding site [nucleotide binding]; other site
320389001555	putative Zn2+ binding site [ion binding]; other site
320389001556	AsnC family; Region: AsnC_trans_reg; pfam01037
320389001557	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389001558	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
320389001559	peptidase domain interface [polypeptide binding]; other site
320389001560	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
320389001561	active site
320389001562	catalytic triad [active]
320389001563	calcium binding site [ion binding]; other site
320389001564	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
320389001565	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
320389001566	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
320389001567	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
320389001568	phosphate binding site [ion binding]; other site
320389001569	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389001570	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001571	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389001572	dimerization interface [polypeptide binding]; other site
320389001573	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
320389001574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001575	putative substrate translocation pore; other site
320389001576	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
320389001577	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389001578	dimer interface [polypeptide binding]; other site
320389001579	putative metal binding site [ion binding]; other site
320389001580	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389001581	MarR family; Region: MarR_2; cl17246
320389001582	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
320389001583	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
320389001584	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
320389001585	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
320389001586	active site
320389001587	Zn binding site [ion binding]; other site
320389001588	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
320389001589	DNA binding site [nucleotide binding]
320389001590	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
320389001591	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
320389001592	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
320389001593	Type III secretion needle MxiH like; Region: MxiH; cl09641
320389001594	type III secretion system protein PrgH/EprH; Region: PrgH; TIGR02554
320389001595	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
320389001596	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389001597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389001598	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389001599	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389001600	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
320389001601	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389001602	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
320389001603	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
320389001604	type III secretion system protein InvA; Provisional; Region: PRK15337
320389001605	Invasion protein B family; Region: Invas_SpaK; cl04129
320389001606	ATP synthase SpaL; Validated; Region: PRK08149
320389001607	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
320389001608	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
320389001609	Walker A motif; other site
320389001610	ATP binding site [chemical binding]; other site
320389001611	Walker B motif; other site
320389001612	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
320389001613	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
320389001614	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
320389001615	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
320389001616	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
320389001617	type III secretion system protein SpaS; Validated; Region: PRK08156
320389001618	chaperone protein SicA; Provisional; Region: PRK15331
320389001619	Tetratricopeptide repeat; Region: TPR_3; pfam07720
320389001620	Tetratricopeptide repeat; Region: TPR_3; pfam07720
320389001621	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
320389001622	Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; pfam09599
320389001623	H-NS histone family; Region: Histone_HNS; pfam00816
320389001624	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389001625	type III effector protein IpaD/SipD/SspD; Region: SipD_IpaD_SspD; TIGR02553
320389001626	Phosphopantetheine attachment site; Region: PP-binding; cl09936
320389001627	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
320389001628	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
320389001629	N-acetyl-D-glucosamine binding site [chemical binding]; other site
320389001630	catalytic residue [active]
320389001631	type III secretion protein BopE; Provisional; Region: PRK15278
320389001632	SopE GEF domain; Region: SopE_GEF; pfam07487
320389001633	SicP binding; Region: SicP-binding; pfam09119
320389001634	chaperone protein SicP; Provisional; Region: PRK15329
320389001635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389001636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389001637	active site
320389001638	phosphorylation site [posttranslational modification]
320389001639	intermolecular recognition site; other site
320389001640	dimerization interface [polypeptide binding]; other site
320389001641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389001642	DNA binding residues [nucleotide binding]
320389001643	dimerization interface [polypeptide binding]; other site
320389001644	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389001645	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389001646	HTH-like domain; Region: HTH_21; pfam13276
320389001647	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001648	Integrase core domain; Region: rve; pfam00665
320389001649	Integrase core domain; Region: rve_3; pfam13683
320389001650	Transposase; Region: HTH_Tnp_1; pfam01527
320389001651	Hemin uptake protein hemP; Region: hemP; pfam10636
320389001652	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
320389001653	putative hydrophobic ligand binding site [chemical binding]; other site
320389001654	Pirin-related protein [General function prediction only]; Region: COG1741
320389001655	Pirin; Region: Pirin; pfam02678
320389001656	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
320389001657	LysR family transcriptional regulator; Provisional; Region: PRK14997
320389001658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001659	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
320389001660	putative effector binding pocket; other site
320389001661	putative dimerization interface [polypeptide binding]; other site
320389001662	Transposase domain (DUF772); Region: DUF772; pfam05598
320389001663	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389001664	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389001665	Transposase; Region: HTH_Tnp_1; pfam01527
320389001666	HTH-like domain; Region: HTH_21; pfam13276
320389001667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001668	Integrase core domain; Region: rve; pfam00665
320389001669	Integrase core domain; Region: rve_3; pfam13683
320389001670	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
320389001671	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
320389001672	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
320389001673	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
320389001674	active site
320389001675	Zn binding site [ion binding]; other site
320389001676	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389001677	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389001678	substrate binding pocket [chemical binding]; other site
320389001679	membrane-bound complex binding site; other site
320389001680	hinge residues; other site
320389001681	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
320389001682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001683	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389001684	dimerization interface [polypeptide binding]; other site
320389001685	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
320389001686	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
320389001687	metal binding site [ion binding]; metal-binding site
320389001688	putative dimer interface [polypeptide binding]; other site
320389001689	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389001690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001691	putative substrate translocation pore; other site
320389001692	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
320389001693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389001694	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
320389001695	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
320389001696	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389001697	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389001698	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
320389001699	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389001700	dimer interface [polypeptide binding]; other site
320389001701	active site
320389001702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389001703	PAS domain; Region: PAS_9; pfam13426
320389001704	putative active site [active]
320389001705	heme pocket [chemical binding]; other site
320389001706	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389001707	dimer interface [polypeptide binding]; other site
320389001708	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
320389001709	putative CheW interface [polypeptide binding]; other site
320389001710	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
320389001711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389001712	S-adenosylmethionine binding site [chemical binding]; other site
320389001713	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
320389001714	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
320389001715	hydrophobic ligand binding site; other site
320389001716	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
320389001717	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
320389001718	iron-sulfur cluster [ion binding]; other site
320389001719	[2Fe-2S] cluster binding site [ion binding]; other site
320389001720	succinic semialdehyde dehydrogenase; Region: PLN02278
320389001721	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
320389001722	tetramerization interface [polypeptide binding]; other site
320389001723	NAD(P) binding site [chemical binding]; other site
320389001724	catalytic residues [active]
320389001725	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
320389001726	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389001727	inhibitor-cofactor binding pocket; inhibition site
320389001728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001729	catalytic residue [active]
320389001730	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389001731	DNA-binding site [nucleotide binding]; DNA binding site
320389001732	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389001733	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389001734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001735	homodimer interface [polypeptide binding]; other site
320389001736	catalytic residue [active]
320389001737	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
320389001738	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
320389001739	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
320389001740	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389001741	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389001742	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
320389001743	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
320389001744	EamA-like transporter family; Region: EamA; cl17759
320389001745	selenophosphate synthetase; Provisional; Region: PRK00943
320389001746	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
320389001747	dimerization interface [polypeptide binding]; other site
320389001748	putative ATP binding site [chemical binding]; other site
320389001749	Purine nucleoside permease (NUP); Region: NUP; pfam06516
320389001750	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389001751	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389001752	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389001753	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
320389001754	putative effector binding pocket; other site
320389001755	putative dimerization interface [polypeptide binding]; other site
320389001756	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
320389001757	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
320389001758	substrate binding pocket [chemical binding]; other site
320389001759	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
320389001760	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389001761	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389001762	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
320389001763	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
320389001764	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
320389001765	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
320389001766	Transcriptional regulators [Transcription]; Region: GntR; COG1802
320389001767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389001768	DNA-binding site [nucleotide binding]; DNA binding site
320389001769	FCD domain; Region: FCD; pfam07729
320389001770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389001771	Coenzyme A binding pocket [chemical binding]; other site
320389001772	Membrane transport protein; Region: Mem_trans; cl09117
320389001773	acyl-CoA synthetase; Validated; Region: PRK05850
320389001774	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
320389001775	acyl-activating enzyme (AAE) consensus motif; other site
320389001776	active site
320389001777	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
320389001778	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
320389001779	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
320389001780	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389001781	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
320389001782	acyl-activating enzyme (AAE) consensus motif; other site
320389001783	AMP binding site [chemical binding]; other site
320389001784	active site
320389001785	CoA binding site [chemical binding]; other site
320389001786	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
320389001787	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
320389001788	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389001789	catalytic residue [active]
320389001790	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
320389001791	Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059
320389001792	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
320389001793	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
320389001794	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
320389001795	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
320389001796	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
320389001797	active site
320389001798	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
320389001799	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
320389001800	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
320389001801	putative NADP binding site [chemical binding]; other site
320389001802	active site
320389001803	Methyltransferase domain; Region: Methyltransf_12; pfam08242
320389001804	Methyltransferase domain; Region: Methyltransf_23; pfam13489
320389001805	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389001806	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
320389001807	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
320389001808	active site
320389001809	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389001810	Condensation domain; Region: Condensation; pfam00668
320389001811	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
320389001812	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
320389001813	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389001814	thioester reductase domain; Region: Thioester-redct; TIGR01746
320389001815	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
320389001816	putative NAD(P) binding site [chemical binding]; other site
320389001817	active site
320389001818	putative substrate binding site [chemical binding]; other site
320389001819	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
320389001820	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389001821	NAD(P) binding site [chemical binding]; other site
320389001822	catalytic residues [active]
320389001823	hypothetical protein; Provisional; Region: PRK07036
320389001824	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389001825	inhibitor-cofactor binding pocket; inhibition site
320389001826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001827	catalytic residue [active]
320389001828	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
320389001829	Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508
320389001830	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389001831	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389001832	DNA binding residues [nucleotide binding]
320389001833	dimerization interface [polypeptide binding]; other site
320389001834	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
320389001835	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
320389001836	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
320389001837	active site
320389001838	non-prolyl cis peptide bond; other site
320389001839	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
320389001840	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
320389001841	Walker A/P-loop; other site
320389001842	ATP binding site [chemical binding]; other site
320389001843	Q-loop/lid; other site
320389001844	ABC transporter signature motif; other site
320389001845	Walker B; other site
320389001846	D-loop; other site
320389001847	H-loop/switch region; other site
320389001848	NIL domain; Region: NIL; pfam09383
320389001849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389001850	dimer interface [polypeptide binding]; other site
320389001851	conserved gate region; other site
320389001852	ABC-ATPase subunit interface; other site
320389001853	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
320389001854	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
320389001855	Flavin binding site [chemical binding]; other site
320389001856	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
320389001857	Cysteine-rich domain; Region: CCG; pfam02754
320389001858	Cysteine-rich domain; Region: CCG; pfam02754
320389001859	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
320389001860	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
320389001861	4Fe-4S binding domain; Region: Fer4; pfam00037
320389001862	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
320389001863	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
320389001864	glycolate transporter; Provisional; Region: PRK09695
320389001865	L-lactate permease; Region: Lactate_perm; cl00701
320389001866	Predicted membrane protein [Function unknown]; Region: COG2259
320389001867	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389001868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001869	putative substrate translocation pore; other site
320389001870	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
320389001871	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
320389001872	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
320389001873	dimer interface [polypeptide binding]; other site
320389001874	NADP binding site [chemical binding]; other site
320389001875	catalytic residues [active]
320389001876	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
320389001877	Spore germination protein; Region: Spore_permease; cl17796
320389001878	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
320389001879	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
320389001880	inhibitor site; inhibition site
320389001881	active site
320389001882	dimer interface [polypeptide binding]; other site
320389001883	catalytic residue [active]
320389001884	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
320389001885	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
320389001886	FAD dependent oxidoreductase; Region: DAO; pfam01266
320389001887	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
320389001888	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
320389001889	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
320389001890	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
320389001891	PAS fold; Region: PAS_4; pfam08448
320389001892	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
320389001893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389001894	HTH-like domain; Region: HTH_21; pfam13276
320389001895	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001896	Integrase core domain; Region: rve; pfam00665
320389001897	Integrase core domain; Region: rve_3; pfam13683
320389001898	Transposase; Region: HTH_Tnp_1; pfam01527
320389001899	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
320389001900	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
320389001901	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
320389001902	dimer interface [polypeptide binding]; other site
320389001903	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
320389001904	active site
320389001905	Fe binding site [ion binding]; other site
320389001906	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
320389001907	Dehydroquinase class II; Region: DHquinase_II; pfam01220
320389001908	active site
320389001909	trimer interface [polypeptide binding]; other site
320389001910	dimer interface [polypeptide binding]; other site
320389001911	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
320389001912	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
320389001913	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
320389001914	shikimate binding site; other site
320389001915	NAD(P) binding site [chemical binding]; other site
320389001916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001917	D-galactonate transporter; Region: 2A0114; TIGR00893
320389001918	putative substrate translocation pore; other site
320389001919	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389001920	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
320389001921	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389001922	catalytic residue [active]
320389001923	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
320389001924	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
320389001925	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
320389001926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389001927	Walker A/P-loop; other site
320389001928	ATP binding site [chemical binding]; other site
320389001929	Q-loop/lid; other site
320389001930	ABC transporter signature motif; other site
320389001931	Walker B; other site
320389001932	D-loop; other site
320389001933	H-loop/switch region; other site
320389001934	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
320389001935	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389001936	dimer interface [polypeptide binding]; other site
320389001937	conserved gate region; other site
320389001938	putative PBP binding loops; other site
320389001939	ABC-ATPase subunit interface; other site
320389001940	2-aminoethylphosphonate ABC transport system, membrane component PhnV; Region: PhnV; TIGR03255
320389001941	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
320389001942	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
320389001943	putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250
320389001944	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
320389001945	NAD(P) binding site [chemical binding]; other site
320389001946	catalytic residues [active]
320389001947	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
320389001948	HTH-like domain; Region: HTH_21; pfam13276
320389001949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001950	Integrase core domain; Region: rve; pfam00665
320389001951	Integrase core domain; Region: rve_3; pfam13683
320389001952	Transposase; Region: HTH_Tnp_1; pfam01527
320389001953	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
320389001954	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
320389001955	4Fe-4S binding domain; Region: Fer4_5; pfam12801
320389001956	Iron permease FTR1 family; Region: FTR1; cl00475
320389001957	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
320389001958	Fe2+ transport protein; Region: Iron_transport; pfam10634
320389001959	excinuclease ABC subunit B; Provisional; Region: PRK05298
320389001960	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
320389001961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389001962	ATP-binding site [chemical binding]; other site
320389001963	ATP binding site [chemical binding]; other site
320389001964	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389001965	nucleotide binding region [chemical binding]; other site
320389001966	ATP-binding site [chemical binding]; other site
320389001967	Ultra-violet resistance protein B; Region: UvrB; pfam12344
320389001968	UvrB/uvrC motif; Region: UVR; pfam02151
320389001969	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
320389001970	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389001971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389001972	homodimer interface [polypeptide binding]; other site
320389001973	catalytic residue [active]
320389001974	Transposase domain (DUF772); Region: DUF772; pfam05598
320389001975	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389001976	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389001977	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
320389001978	classical (c) SDRs; Region: SDR_c; cd05233
320389001979	NAD(P) binding site [chemical binding]; other site
320389001980	active site
320389001981	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
320389001982	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
320389001983	active site
320389001984	catalytic tetrad [active]
320389001985	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
320389001986	Transposase; Region: HTH_Tnp_1; pfam01527
320389001987	HTH-like domain; Region: HTH_21; pfam13276
320389001988	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001989	Integrase core domain; Region: rve; pfam00665
320389001990	Integrase core domain; Region: rve_3; pfam13683
320389001991	Bacitracin resistance protein BacA; Region: BacA; cl00858
320389001992	HTH-like domain; Region: HTH_21; pfam13276
320389001993	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389001994	Integrase core domain; Region: rve; pfam00665
320389001995	Integrase core domain; Region: rve_3; pfam13683
320389001996	Transposase; Region: HTH_Tnp_1; pfam01527
320389001997	DEAD_2; Region: DEAD_2; pfam06733
320389001998	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
320389001999	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
320389002000	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
320389002001	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
320389002002	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
320389002003	flagellar capping protein; Reviewed; Region: fliD; PRK08032
320389002004	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
320389002005	transcriptional regulator; Provisional; Region: PRK10632
320389002006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389002007	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389002008	putative effector binding pocket; other site
320389002009	dimerization interface [polypeptide binding]; other site
320389002010	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
320389002011	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
320389002012	catalytic residues [active]
320389002013	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
320389002014	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
320389002015	active site
320389002016	catalytic tetrad [active]
320389002017	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
320389002018	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
320389002019	classical (c) SDRs; Region: SDR_c; cd05233
320389002020	NAD(P) binding site [chemical binding]; other site
320389002021	active site
320389002022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389002023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389002024	DNA binding residues [nucleotide binding]
320389002025	dimerization interface [polypeptide binding]; other site
320389002026	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389002027	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389002028	NAD(P) binding site [chemical binding]; other site
320389002029	catalytic residues [active]
320389002030	hypothetical protein; Provisional; Region: PRK07481
320389002031	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389002032	inhibitor-cofactor binding pocket; inhibition site
320389002033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389002034	catalytic residue [active]
320389002035	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
320389002036	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
320389002037	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389002038	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389002039	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389002040	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389002041	eyelet of channel; other site
320389002042	trimer interface [polypeptide binding]; other site
320389002043	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389002044	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
320389002045	Coenzyme A binding pocket [chemical binding]; other site
320389002046	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
320389002047	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
320389002048	FMN binding site [chemical binding]; other site
320389002049	active site
320389002050	substrate binding site [chemical binding]; other site
320389002051	catalytic residue [active]
320389002052	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389002053	putative DNA binding site [nucleotide binding]; other site
320389002054	dimerization interface [polypeptide binding]; other site
320389002055	putative Zn2+ binding site [ion binding]; other site
320389002056	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389002057	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389002058	trimer interface [polypeptide binding]; other site
320389002059	eyelet of channel; other site
320389002060	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
320389002061	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
320389002062	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389002063	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
320389002064	FOG: CBS domain [General function prediction only]; Region: COG0517
320389002065	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
320389002066	dimerization interface [polypeptide binding]; other site
320389002067	active site
320389002068	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
320389002069	NADH/NADPH cofactor binding site [chemical binding]; other site
320389002070	Autoinducer synthetase; Region: Autoind_synth; cl17404
320389002071	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
320389002072	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389002073	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389002074	DNA binding residues [nucleotide binding]
320389002075	dimerization interface [polypeptide binding]; other site
320389002076	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
320389002077	MgtC family; Region: MgtC; pfam02308
320389002078	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
320389002079	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389002080	putative active site [active]
320389002081	putative metal binding site [ion binding]; other site
320389002082	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
320389002083	putative FMN binding site [chemical binding]; other site
320389002084	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
320389002085	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389002086	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389002087	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389002088	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389002089	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389002090	trimer interface [polypeptide binding]; other site
320389002091	eyelet of channel; other site
320389002092	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
320389002093	[2Fe-2S] cluster binding site [ion binding]; other site
320389002094	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
320389002095	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
320389002096	[2Fe-2S] cluster binding site [ion binding]; other site
320389002097	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
320389002098	hydrophobic ligand binding site; other site
320389002099	short chain dehydrogenase; Provisional; Region: PRK12939
320389002100	classical (c) SDRs; Region: SDR_c; cd05233
320389002101	NAD(P) binding site [chemical binding]; other site
320389002102	active site
320389002103	Cupin domain; Region: Cupin_2; pfam07883
320389002104	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389002105	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389002106	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389002107	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389002108	short chain dehydrogenase; Provisional; Region: PRK07062
320389002109	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
320389002110	putative NAD(P) binding site [chemical binding]; other site
320389002111	putative active site [active]
320389002112	hypothetical protein; Provisional; Region: PRK07064
320389002113	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
320389002114	PYR/PP interface [polypeptide binding]; other site
320389002115	dimer interface [polypeptide binding]; other site
320389002116	TPP binding site [chemical binding]; other site
320389002117	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389002118	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
320389002119	TPP-binding site [chemical binding]; other site
320389002120	L-aspartate dehydrogenase; Provisional; Region: PRK13303
320389002121	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
320389002122	Domain of unknown function DUF108; Region: DUF108; pfam01958
320389002123	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389002124	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
320389002125	NAD(P) binding site [chemical binding]; other site
320389002126	catalytic residues [active]
320389002127	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
320389002128	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
320389002129	active site
320389002130	metal binding site [ion binding]; metal-binding site
320389002131	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
320389002132	putative active site [active]
320389002133	putative metal binding site [ion binding]; other site
320389002134	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
320389002135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389002136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389002137	benzoate transport; Region: 2A0115; TIGR00895
320389002138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002139	putative substrate translocation pore; other site
320389002140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002141	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389002142	trimer interface [polypeptide binding]; other site
320389002143	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389002144	trimer interface [polypeptide binding]; other site
320389002145	Haemagglutinin; Region: HIM; pfam05662
320389002146	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389002147	trimer interface [polypeptide binding]; other site
320389002148	Haemagglutinin; Region: HIM; pfam05662
320389002149	Haemagglutinin; Region: HIM; pfam05662
320389002150	YadA-like C-terminal region; Region: YadA; pfam03895
320389002151	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
320389002152	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
320389002153	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389002154	ligand binding site [chemical binding]; other site
320389002155	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389002156	Ligand Binding Site [chemical binding]; other site
320389002157	amidase; Provisional; Region: PRK07486
320389002158	Amidase; Region: Amidase; cl11426
320389002159	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389002160	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389002161	dimerization interface [polypeptide binding]; other site
320389002162	putative DNA binding site [nucleotide binding]; other site
320389002163	putative Zn2+ binding site [ion binding]; other site
320389002164	AsnC family; Region: AsnC_trans_reg; pfam01037
320389002165	methionine gamma-lyase; Validated; Region: PRK07049
320389002166	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
320389002167	homodimer interface [polypeptide binding]; other site
320389002168	substrate-cofactor binding pocket; other site
320389002169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389002170	catalytic residue [active]
320389002171	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
320389002172	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
320389002173	Predicted transcriptional regulator [Transcription]; Region: COG1959
320389002174	Transcriptional regulator; Region: Rrf2; pfam02082
320389002175	HTH-like domain; Region: HTH_21; pfam13276
320389002176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002177	Integrase core domain; Region: rve; pfam00665
320389002178	Integrase core domain; Region: rve_3; pfam13683
320389002179	Transposase; Region: HTH_Tnp_1; pfam01527
320389002180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002181	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389002182	putative substrate translocation pore; other site
320389002183	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389002184	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
320389002185	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
320389002186	short chain dehydrogenase; Provisional; Region: PRK07832
320389002187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389002188	NAD(P) binding site [chemical binding]; other site
320389002189	active site
320389002190	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
320389002191	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
320389002192	YhhN-like protein; Region: YhhN; pfam07947
320389002193	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
320389002194	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389002195	substrate binding pocket [chemical binding]; other site
320389002196	membrane-bound complex binding site; other site
320389002197	hinge residues; other site
320389002198	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
320389002199	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
320389002200	DNA binding residues [nucleotide binding]
320389002201	putative dimer interface [polypeptide binding]; other site
320389002202	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
320389002203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389002204	Coenzyme A binding pocket [chemical binding]; other site
320389002205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002206	putative substrate translocation pore; other site
320389002207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002208	putative substrate translocation pore; other site
320389002209	Family description; Region: UvrD_C_2; pfam13538
320389002210	BetR domain; Region: BetR; pfam08667
320389002211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389002212	active site
320389002213	phosphorylation site [posttranslational modification]
320389002214	intermolecular recognition site; other site
320389002215	dimerization interface [polypeptide binding]; other site
320389002216	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
320389002217	hydroxyglutarate oxidase; Provisional; Region: PRK11728
320389002218	Ion channel; Region: Ion_trans_2; pfam07885
320389002219	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
320389002220	TrkA-N domain; Region: TrkA_N; pfam02254
320389002221	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389002222	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
320389002223	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
320389002224	ornithine cyclodeaminase; Validated; Region: PRK07340
320389002225	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
320389002226	Putative esterase; Region: Esterase; pfam00756
320389002227	OpgC protein; Region: OpgC_C; pfam10129
320389002228	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389002229	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389002230	trimer interface [polypeptide binding]; other site
320389002231	eyelet of channel; other site
320389002232	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389002233	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389002234	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
320389002235	putative dimerization interface [polypeptide binding]; other site
320389002236	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
320389002237	Peptidase family M23; Region: Peptidase_M23; pfam01551
320389002238	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
320389002239	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
320389002240	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389002241	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
320389002242	substrate binding pocket [chemical binding]; other site
320389002243	dimerization interface [polypeptide binding]; other site
320389002244	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
320389002245	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389002246	Walker A/P-loop; other site
320389002247	ATP binding site [chemical binding]; other site
320389002248	Q-loop/lid; other site
320389002249	ABC transporter signature motif; other site
320389002250	Walker B; other site
320389002251	D-loop; other site
320389002252	H-loop/switch region; other site
320389002253	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
320389002254	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389002255	Walker A/P-loop; other site
320389002256	ATP binding site [chemical binding]; other site
320389002257	Q-loop/lid; other site
320389002258	ABC transporter signature motif; other site
320389002259	Walker B; other site
320389002260	D-loop; other site
320389002261	H-loop/switch region; other site
320389002262	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
320389002263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002264	dimer interface [polypeptide binding]; other site
320389002265	conserved gate region; other site
320389002266	putative PBP binding loops; other site
320389002267	ABC-ATPase subunit interface; other site
320389002268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
320389002269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002270	dimer interface [polypeptide binding]; other site
320389002271	conserved gate region; other site
320389002272	putative PBP binding loops; other site
320389002273	ABC-ATPase subunit interface; other site
320389002274	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
320389002275	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
320389002276	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
320389002277	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389002278	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389002279	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
320389002280	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
320389002281	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389002282	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389002283	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
320389002284	PAAR motif; Region: PAAR_motif; pfam05488
320389002285	RHS Repeat; Region: RHS_repeat; cl11982
320389002286	RHS Repeat; Region: RHS_repeat; pfam05593
320389002287	RHS Repeat; Region: RHS_repeat; cl11982
320389002288	RHS Repeat; Region: RHS_repeat; pfam05593
320389002289	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
320389002290	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
320389002291	RHS Repeat; Region: RHS_repeat; pfam05593
320389002292	RHS Repeat; Region: RHS_repeat; cl11982
320389002293	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
320389002294	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
320389002295	catalytic triad [active]
320389002296	putative active site [active]
320389002297	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
320389002298	Autotransporter beta-domain; Region: Autotransporter; smart00869
320389002299	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
320389002300	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
320389002301	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
320389002302	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
320389002303	Cupin; Region: Cupin_1; smart00835
320389002304	Cupin; Region: Cupin_1; smart00835
320389002305	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
320389002306	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
320389002307	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
320389002308	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
320389002309	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
320389002310	putative molybdopterin cofactor binding site [chemical binding]; other site
320389002311	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
320389002312	putative molybdopterin cofactor binding site; other site
320389002313	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389002314	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389002315	DNA-binding site [nucleotide binding]; DNA binding site
320389002316	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389002317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389002318	homodimer interface [polypeptide binding]; other site
320389002319	catalytic residue [active]
320389002320	magnesium-transporting ATPase; Provisional; Region: PRK15122
320389002321	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
320389002322	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
320389002323	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
320389002324	Soluble P-type ATPase [General function prediction only]; Region: COG4087
320389002325	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
320389002326	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
320389002327	active site
320389002328	catalytic triad [active]
320389002329	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
320389002330	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
320389002331	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
320389002332	Cytochrome c; Region: Cytochrom_C; pfam00034
320389002333	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
320389002334	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
320389002335	Cytochrome c; Region: Cytochrom_C; pfam00034
320389002336	Predicted membrane protein [Function unknown]; Region: COG2259
320389002337	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389002338	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389002339	trimer interface [polypeptide binding]; other site
320389002340	eyelet of channel; other site
320389002341	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
320389002342	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389002343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002344	dimer interface [polypeptide binding]; other site
320389002345	conserved gate region; other site
320389002346	putative PBP binding loops; other site
320389002347	ABC-ATPase subunit interface; other site
320389002348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002349	dimer interface [polypeptide binding]; other site
320389002350	conserved gate region; other site
320389002351	putative PBP binding loops; other site
320389002352	ABC-ATPase subunit interface; other site
320389002353	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
320389002354	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389002355	Walker A/P-loop; other site
320389002356	ATP binding site [chemical binding]; other site
320389002357	Q-loop/lid; other site
320389002358	ABC transporter signature motif; other site
320389002359	Walker B; other site
320389002360	D-loop; other site
320389002361	H-loop/switch region; other site
320389002362	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
320389002363	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
320389002364	putative active site [active]
320389002365	Uncharacterized conserved protein [Function unknown]; Region: COG3791
320389002366	Histidine kinase; Region: His_kinase; pfam06580
320389002367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389002368	ATP binding site [chemical binding]; other site
320389002369	Mg2+ binding site [ion binding]; other site
320389002370	G-X-G motif; other site
320389002371	HTH-like domain; Region: HTH_21; pfam13276
320389002372	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002373	Integrase core domain; Region: rve; pfam00665
320389002374	Integrase core domain; Region: rve_3; pfam13683
320389002375	Transposase; Region: HTH_Tnp_1; pfam01527
320389002376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389002377	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389002378	S-adenosylmethionine binding site [chemical binding]; other site
320389002379	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
320389002380	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389002381	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
320389002382	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
320389002383	iron-sulfur cluster [ion binding]; other site
320389002384	[2Fe-2S] cluster binding site [ion binding]; other site
320389002385	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
320389002386	hydrophobic ligand binding site; other site
320389002387	TPR repeat; Region: TPR_11; pfam13414
320389002388	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
320389002389	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
320389002390	dimer interface [polypeptide binding]; other site
320389002391	active site
320389002392	acyl carrier protein; Validated; Region: PRK07117
320389002393	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
320389002394	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389002395	substrate binding site [chemical binding]; other site
320389002396	oxyanion hole (OAH) forming residues; other site
320389002397	trimer interface [polypeptide binding]; other site
320389002398	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389002399	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
320389002400	substrate binding site [chemical binding]; other site
320389002401	oxyanion hole (OAH) forming residues; other site
320389002402	trimer interface [polypeptide binding]; other site
320389002403	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389002404	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389002405	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
320389002406	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
320389002407	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
320389002408	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
320389002409	KR domain; Region: KR; pfam08659
320389002410	putative NADP binding site [chemical binding]; other site
320389002411	active site
320389002412	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
320389002413	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
320389002414	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
320389002415	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389002416	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389002417	catalytic residue [active]
320389002418	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
320389002419	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
320389002420	active site
320389002421	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
320389002422	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
320389002423	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
320389002424	active site
320389002425	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
320389002426	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389002427	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
320389002428	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
320389002429	Cl- selectivity filter; other site
320389002430	Cl- binding residues [ion binding]; other site
320389002431	pore gating glutamate residue; other site
320389002432	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
320389002433	MarR family; Region: MarR_2; pfam12802
320389002434	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
320389002435	HPP family; Region: HPP; pfam04982
320389002436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
320389002437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389002438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389002439	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389002440	putative effector binding pocket; other site
320389002441	dimerization interface [polypeptide binding]; other site
320389002442	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
320389002443	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
320389002444	CAAX protease self-immunity; Region: Abi; cl00558
320389002445	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
320389002446	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
320389002447	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389002448	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389002449	RNA polymerase sigma factor; Provisional; Region: PRK12547
320389002450	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389002451	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389002452	DNA binding residues [nucleotide binding]
320389002453	YceI-like domain; Region: YceI; pfam04264
320389002454	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
320389002455	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
320389002456	RNA polymerase sigma factor; Provisional; Region: PRK12528
320389002457	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389002458	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389002459	DNA binding residues [nucleotide binding]
320389002460	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
320389002461	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389002462	N-terminal plug; other site
320389002463	ligand-binding site [chemical binding]; other site
320389002464	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389002465	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
320389002466	TM-ABC transporter signature motif; other site
320389002467	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
320389002468	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
320389002469	Walker A/P-loop; other site
320389002470	ATP binding site [chemical binding]; other site
320389002471	Q-loop/lid; other site
320389002472	ABC transporter signature motif; other site
320389002473	Walker B; other site
320389002474	D-loop; other site
320389002475	H-loop/switch region; other site
320389002476	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
320389002477	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
320389002478	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
320389002479	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
320389002480	putative ligand binding site [chemical binding]; other site
320389002481	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
320389002482	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
320389002483	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389002484	active site
320389002485	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
320389002486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002487	putative substrate translocation pore; other site
320389002488	HTH-like domain; Region: HTH_21; pfam13276
320389002489	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002490	Integrase core domain; Region: rve; pfam00665
320389002491	Integrase core domain; Region: rve_3; pfam13683
320389002492	Transposase; Region: HTH_Tnp_1; pfam01527
320389002493	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389002494	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
320389002495	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389002496	dimerization interface [polypeptide binding]; other site
320389002497	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389002498	dimer interface [polypeptide binding]; other site
320389002499	phosphorylation site [posttranslational modification]
320389002500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389002501	ATP binding site [chemical binding]; other site
320389002502	Mg2+ binding site [ion binding]; other site
320389002503	G-X-G motif; other site
320389002504	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
320389002505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389002506	active site
320389002507	phosphorylation site [posttranslational modification]
320389002508	intermolecular recognition site; other site
320389002509	dimerization interface [polypeptide binding]; other site
320389002510	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389002511	DNA binding site [nucleotide binding]
320389002512	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
320389002513	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389002514	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
320389002515	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389002516	Outer membrane efflux protein; Region: OEP; pfam02321
320389002517	Outer membrane efflux protein; Region: OEP; pfam02321
320389002518	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
320389002519	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
320389002520	putative deacylase active site [active]
320389002521	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
320389002522	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
320389002523	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
320389002524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389002525	Walker A motif; other site
320389002526	ATP binding site [chemical binding]; other site
320389002527	Walker B motif; other site
320389002528	arginine finger; other site
320389002529	Peptidase family M41; Region: Peptidase_M41; pfam01434
320389002530	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
320389002531	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389002532	active site
320389002533	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389002534	Predicted transcriptional regulator [Transcription]; Region: COG2345
320389002535	MarR family; Region: MarR_2; pfam12802
320389002536	Transcriptional regulator PadR-like family; Region: PadR; cl17335
320389002537	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
320389002538	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
320389002539	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389002540	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389002541	multidrug efflux protein; Reviewed; Region: PRK09579
320389002542	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
320389002543	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
320389002544	dimerization interface [polypeptide binding]; other site
320389002545	active site
320389002546	FOG: WD40 repeat [General function prediction only]; Region: COG2319
320389002547	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
320389002548	structural tetrad; other site
320389002549	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
320389002550	structural tetrad; other site
320389002551	FOG: WD40 repeat [General function prediction only]; Region: COG2319
320389002552	Methyltransferase domain; Region: Methyltransf_23; pfam13489
320389002553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389002554	S-adenosylmethionine binding site [chemical binding]; other site
320389002555	Phage integrase protein; Region: DUF3701; pfam12482
320389002556	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
320389002557	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
320389002558	Int/Topo IB signature motif; other site
320389002559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
320389002560	Domain of Unknown Function (DUF746); Region: DUF746; pfam05344
320389002561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
320389002562	Domain of Unknown Function (DUF746); Region: DUF746; pfam05344
320389002563	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
320389002564	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
320389002565	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
320389002566	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
320389002567	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
320389002568	ligand binding site [chemical binding]; other site
320389002569	short chain dehydrogenase; Provisional; Region: PRK07074
320389002570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389002571	NAD(P) binding site [chemical binding]; other site
320389002572	active site
320389002573	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
320389002574	putative cation:proton antiport protein; Provisional; Region: PRK10669
320389002575	TrkA-N domain; Region: TrkA_N; pfam02254
320389002576	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
320389002577	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
320389002578	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
320389002579	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
320389002580	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
320389002581	dimer interface [polypeptide binding]; other site
320389002582	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
320389002583	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
320389002584	Cl binding site [ion binding]; other site
320389002585	oligomer interface [polypeptide binding]; other site
320389002586	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
320389002587	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
320389002588	Electron transfer DM13; Region: DM13; pfam10517
320389002589	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
320389002590	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
320389002591	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
320389002592	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
320389002593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002594	dimer interface [polypeptide binding]; other site
320389002595	conserved gate region; other site
320389002596	putative PBP binding loops; other site
320389002597	ABC-ATPase subunit interface; other site
320389002598	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
320389002599	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
320389002600	inhibitor binding site; inhibition site
320389002601	catalytic Zn binding site [ion binding]; other site
320389002602	structural Zn binding site [ion binding]; other site
320389002603	NADP binding site [chemical binding]; other site
320389002604	tetramer interface [polypeptide binding]; other site
320389002605	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
320389002606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389002607	Walker A/P-loop; other site
320389002608	ATP binding site [chemical binding]; other site
320389002609	Q-loop/lid; other site
320389002610	ABC transporter signature motif; other site
320389002611	Walker B; other site
320389002612	D-loop; other site
320389002613	H-loop/switch region; other site
320389002614	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389002615	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
320389002616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389002617	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389002618	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
320389002619	N- and C-terminal domain interface [polypeptide binding]; other site
320389002620	D-xylulose kinase; Region: XylB; TIGR01312
320389002621	active site
320389002622	MgATP binding site [chemical binding]; other site
320389002623	catalytic site [active]
320389002624	metal binding site [ion binding]; metal-binding site
320389002625	xylulose binding site [chemical binding]; other site
320389002626	homodimer interface [polypeptide binding]; other site
320389002627	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
320389002628	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
320389002629	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
320389002630	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
320389002631	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
320389002632	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
320389002633	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
320389002634	[4Fe-4S] binding site [ion binding]; other site
320389002635	molybdopterin cofactor binding site; other site
320389002636	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
320389002637	molybdopterin cofactor binding site; other site
320389002638	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
320389002639	Flavodoxin; Region: Flavodoxin_1; pfam00258
320389002640	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
320389002641	FAD binding pocket [chemical binding]; other site
320389002642	FAD binding motif [chemical binding]; other site
320389002643	catalytic residues [active]
320389002644	NAD binding pocket [chemical binding]; other site
320389002645	phosphate binding motif [ion binding]; other site
320389002646	beta-alpha-beta structure motif; other site
320389002647	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
320389002648	nitrite reductase subunit NirD; Provisional; Region: PRK14989
320389002649	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389002650	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
320389002651	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389002652	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
320389002653	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
320389002654	active site
320389002655	SAM binding site [chemical binding]; other site
320389002656	homodimer interface [polypeptide binding]; other site
320389002657	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
320389002658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389002659	active site
320389002660	phosphorylation site [posttranslational modification]
320389002661	intermolecular recognition site; other site
320389002662	dimerization interface [polypeptide binding]; other site
320389002663	ANTAR domain; Region: ANTAR; pfam03861
320389002664	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
320389002665	NMT1-like family; Region: NMT1_2; pfam13379
320389002666	GTP cyclohydrolase I; Reviewed; Region: PRK12606
320389002667	GTP cyclohydrolase I; Provisional; Region: PLN03044
320389002668	active site
320389002669	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
320389002670	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
320389002671	active site
320389002672	Zn binding site [ion binding]; other site
320389002673	allantoate amidohydrolase; Reviewed; Region: PRK12893
320389002674	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
320389002675	active site
320389002676	metal binding site [ion binding]; metal-binding site
320389002677	dimer interface [polypeptide binding]; other site
320389002678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002679	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389002680	putative substrate translocation pore; other site
320389002681	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389002682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389002683	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
320389002684	putative effector binding pocket; other site
320389002685	putative dimerization interface [polypeptide binding]; other site
320389002686	short chain dehydrogenase; Provisional; Region: PRK12937
320389002687	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
320389002688	NADP binding site [chemical binding]; other site
320389002689	homodimer interface [polypeptide binding]; other site
320389002690	active site
320389002691	substrate binding site [chemical binding]; other site
320389002692	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
320389002693	CoA-transferase family III; Region: CoA_transf_3; pfam02515
320389002694	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
320389002695	Prostaglandin dehydrogenases; Region: PGDH; cd05288
320389002696	NAD(P) binding site [chemical binding]; other site
320389002697	substrate binding site [chemical binding]; other site
320389002698	dimer interface [polypeptide binding]; other site
320389002699	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
320389002700	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
320389002701	dimer interface [polypeptide binding]; other site
320389002702	active site
320389002703	metal binding site [ion binding]; metal-binding site
320389002704	Peptidase M66; Region: Peptidase_M66; pfam10462
320389002705	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
320389002706	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
320389002707	Domain of unknown function (DUF802); Region: DUF802; pfam05650
320389002708	hypothetical protein; Provisional; Region: PRK09040
320389002709	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389002710	ligand binding site [chemical binding]; other site
320389002711	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
320389002712	Condensation domain; Region: Condensation; pfam00668
320389002713	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389002714	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
320389002715	acyl-activating enzyme (AAE) consensus motif; other site
320389002716	AMP binding site [chemical binding]; other site
320389002717	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389002718	MbtH-like protein; Region: MbtH; pfam03621
320389002719	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389002720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
320389002721	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
320389002722	Transposase domain (DUF772); Region: DUF772; pfam05598
320389002723	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389002724	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389002725	HTH-like domain; Region: HTH_21; pfam13276
320389002726	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002727	Integrase core domain; Region: rve; pfam00665
320389002728	Integrase core domain; Region: rve_3; pfam13683
320389002729	Transposase; Region: HTH_Tnp_1; pfam01527
320389002730	Biofilm formation and stress response factor; Region: BsmA; pfam10014
320389002731	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
320389002732	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389002733	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
320389002734	active site
320389002735	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389002736	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
320389002737	active site
320389002738	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
320389002739	acyl-CoA synthetase; Validated; Region: PRK05850
320389002740	acyl-activating enzyme (AAE) consensus motif; other site
320389002741	active site
320389002742	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
320389002743	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389002744	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389002745	DNA binding residues [nucleotide binding]
320389002746	Uncharacterized conserved protein [Function unknown]; Region: COG1739
320389002747	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
320389002748	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
320389002749	EamA-like transporter family; Region: EamA; pfam00892
320389002750	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
320389002751	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
320389002752	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
320389002753	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
320389002754	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389002755	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389002756	HTH-like domain; Region: HTH_21; pfam13276
320389002757	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002758	Integrase core domain; Region: rve; pfam00665
320389002759	Integrase core domain; Region: rve_3; pfam13683
320389002760	Transposase; Region: HTH_Tnp_1; pfam01527
320389002761	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
320389002762	catalytic residue [active]
320389002763	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
320389002764	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
320389002765	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
320389002766	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
320389002767	linker region; other site
320389002768	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389002769	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
320389002770	putative acyl-acceptor binding pocket; other site
320389002771	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
320389002772	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
320389002773	putative active site [active]
320389002774	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
320389002775	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
320389002776	Walker A/P-loop; other site
320389002777	ATP binding site [chemical binding]; other site
320389002778	Q-loop/lid; other site
320389002779	ABC transporter signature motif; other site
320389002780	Walker B; other site
320389002781	D-loop; other site
320389002782	H-loop/switch region; other site
320389002783	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
320389002784	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
320389002785	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
320389002786	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
320389002787	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
320389002788	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389002789	ATP binding site [chemical binding]; other site
320389002790	putative Mg++ binding site [ion binding]; other site
320389002791	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389002792	nucleotide binding region [chemical binding]; other site
320389002793	ATP-binding site [chemical binding]; other site
320389002794	DEAD/H associated; Region: DEAD_assoc; pfam08494
320389002795	HTH-like domain; Region: HTH_21; pfam13276
320389002796	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002797	Integrase core domain; Region: rve; pfam00665
320389002798	Integrase core domain; Region: rve_3; pfam13683
320389002799	Transposase; Region: HTH_Tnp_1; pfam01527
320389002800	putative transporter; Provisional; Region: PRK11021
320389002801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
320389002802	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
320389002803	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
320389002804	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
320389002805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389002806	S-adenosylmethionine binding site [chemical binding]; other site
320389002807	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389002808	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389002809	metal binding site [ion binding]; metal-binding site
320389002810	active site
320389002811	I-site; other site
320389002812	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
320389002813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389002814	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389002815	dimerization interface [polypeptide binding]; other site
320389002816	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
320389002817	heterodimer interface [polypeptide binding]; other site
320389002818	multimer interface [polypeptide binding]; other site
320389002819	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
320389002820	active site
320389002821	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
320389002822	active site
320389002823	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
320389002824	SxDxEG motif; other site
320389002825	active site
320389002826	metal binding site [ion binding]; metal-binding site
320389002827	homopentamer interface [polypeptide binding]; other site
320389002828	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
320389002829	homotetramer interface [polypeptide binding]; other site
320389002830	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
320389002831	cleavage site
320389002832	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
320389002833	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
320389002834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002835	dimer interface [polypeptide binding]; other site
320389002836	conserved gate region; other site
320389002837	putative PBP binding loops; other site
320389002838	ABC-ATPase subunit interface; other site
320389002839	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
320389002840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389002841	dimer interface [polypeptide binding]; other site
320389002842	conserved gate region; other site
320389002843	putative PBP binding loops; other site
320389002844	ABC-ATPase subunit interface; other site
320389002845	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
320389002846	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
320389002847	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
320389002848	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389002849	Walker A/P-loop; other site
320389002850	ATP binding site [chemical binding]; other site
320389002851	Q-loop/lid; other site
320389002852	ABC transporter signature motif; other site
320389002853	Walker B; other site
320389002854	D-loop; other site
320389002855	H-loop/switch region; other site
320389002856	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
320389002857	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
320389002858	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389002859	Walker A/P-loop; other site
320389002860	ATP binding site [chemical binding]; other site
320389002861	Q-loop/lid; other site
320389002862	ABC transporter signature motif; other site
320389002863	Walker B; other site
320389002864	D-loop; other site
320389002865	H-loop/switch region; other site
320389002866	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389002867	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
320389002868	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
320389002869	catalytic nucleophile [active]
320389002870	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389002871	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389002872	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
320389002873	putative active site [active]
320389002874	BCCT family transporter; Region: BCCT; pfam02028
320389002875	Beta-lactamase; Region: Beta-lactamase; pfam00144
320389002876	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
320389002877	Phosphoesterase family; Region: Phosphoesterase; pfam04185
320389002878	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
320389002879	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
320389002880	active site
320389002881	HIGH motif; other site
320389002882	nucleotide binding site [chemical binding]; other site
320389002883	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
320389002884	active site
320389002885	KMSKS motif; other site
320389002886	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
320389002887	tRNA binding surface [nucleotide binding]; other site
320389002888	anticodon binding site; other site
320389002889	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
320389002890	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
320389002891	EamA-like transporter family; Region: EamA; pfam00892
320389002892	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
320389002893	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
320389002894	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
320389002895	FAD binding domain; Region: FAD_binding_4; pfam01565
320389002896	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
320389002897	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389002898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389002899	S-adenosylmethionine binding site [chemical binding]; other site
320389002900	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389002901	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389002902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389002903	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
320389002904	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
320389002905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389002906	catalytic residue [active]
320389002907	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
320389002908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389002909	putative DNA binding site [nucleotide binding]; other site
320389002910	putative Zn2+ binding site [ion binding]; other site
320389002911	AsnC family; Region: AsnC_trans_reg; pfam01037
320389002912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002913	putative substrate translocation pore; other site
320389002914	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
320389002915	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389002916	DNA-binding site [nucleotide binding]; DNA binding site
320389002917	UTRA domain; Region: UTRA; pfam07702
320389002918	benzoate transport; Region: 2A0115; TIGR00895
320389002919	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002920	putative substrate translocation pore; other site
320389002921	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
320389002922	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389002923	active site
320389002924	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389002925	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
320389002926	active site
320389002927	metal binding site [ion binding]; metal-binding site
320389002928	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
320389002929	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
320389002930	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
320389002931	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
320389002932	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
320389002933	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389002934	Coenzyme A binding pocket [chemical binding]; other site
320389002935	Predicted transporter component [General function prediction only]; Region: COG2391
320389002936	Sulphur transport; Region: Sulf_transp; pfam04143
320389002937	Predicted transporter component [General function prediction only]; Region: COG2391
320389002938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389002939	dimerization interface [polypeptide binding]; other site
320389002940	putative DNA binding site [nucleotide binding]; other site
320389002941	putative Zn2+ binding site [ion binding]; other site
320389002942	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
320389002943	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
320389002944	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
320389002945	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389002946	catalytic residue [active]
320389002947	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389002948	non-specific DNA binding site [nucleotide binding]; other site
320389002949	salt bridge; other site
320389002950	sequence-specific DNA binding site [nucleotide binding]; other site
320389002951	serine O-acetyltransferase; Region: cysE; TIGR01172
320389002952	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
320389002953	trimer interface [polypeptide binding]; other site
320389002954	active site
320389002955	substrate binding site [chemical binding]; other site
320389002956	CoA binding site [chemical binding]; other site
320389002957	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
320389002958	active site residue [active]
320389002959	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
320389002960	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
320389002961	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
320389002962	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389002963	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389002964	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
320389002965	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
320389002966	Ligand binding site; other site
320389002967	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389002968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002969	putative substrate translocation pore; other site
320389002970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002971	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
320389002972	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
320389002973	active site
320389002974	TDP-binding site; other site
320389002975	acceptor substrate-binding pocket; other site
320389002976	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389002977	HTH-like domain; Region: HTH_21; pfam13276
320389002978	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389002979	Integrase core domain; Region: rve; pfam00665
320389002980	Integrase core domain; Region: rve_3; pfam13683
320389002981	Transposase; Region: HTH_Tnp_1; pfam01527
320389002982	transcriptional regulator BetI; Validated; Region: PRK00767
320389002983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389002984	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
320389002985	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
320389002986	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389002987	NAD(P) binding site [chemical binding]; other site
320389002988	catalytic residues [active]
320389002989	choline dehydrogenase; Validated; Region: PRK02106
320389002990	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
320389002991	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
320389002992	benzoate transport; Region: 2A0115; TIGR00895
320389002993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002994	putative substrate translocation pore; other site
320389002995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389002996	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
320389002997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389002998	active site
320389002999	phosphorylation site [posttranslational modification]
320389003000	intermolecular recognition site; other site
320389003001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389003002	PAS fold; Region: PAS_3; pfam08447
320389003003	putative active site [active]
320389003004	heme pocket [chemical binding]; other site
320389003005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
320389003006	Histidine kinase; Region: HisKA_3; pfam07730
320389003007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003008	ATP binding site [chemical binding]; other site
320389003009	Mg2+ binding site [ion binding]; other site
320389003010	G-X-G motif; other site
320389003011	Response regulator receiver domain; Region: Response_reg; pfam00072
320389003012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003013	active site
320389003014	phosphorylation site [posttranslational modification]
320389003015	intermolecular recognition site; other site
320389003016	dimerization interface [polypeptide binding]; other site
320389003017	CHASE3 domain; Region: CHASE3; pfam05227
320389003018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389003019	PAS domain; Region: PAS_9; pfam13426
320389003020	putative active site [active]
320389003021	heme pocket [chemical binding]; other site
320389003022	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
320389003023	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389003024	putative active site [active]
320389003025	heme pocket [chemical binding]; other site
320389003026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389003027	dimer interface [polypeptide binding]; other site
320389003028	phosphorylation site [posttranslational modification]
320389003029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003030	ATP binding site [chemical binding]; other site
320389003031	Mg2+ binding site [ion binding]; other site
320389003032	G-X-G motif; other site
320389003033	OsmC-like protein; Region: OsmC; cl00767
320389003034	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
320389003035	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
320389003036	putative ligand binding site [chemical binding]; other site
320389003037	NAD binding site [chemical binding]; other site
320389003038	catalytic site [active]
320389003039	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
320389003040	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
320389003041	DNA-binding site [nucleotide binding]; DNA binding site
320389003042	RNA-binding motif; other site
320389003043	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
320389003044	active site
320389003045	Transposase; Region: HTH_Tnp_1; pfam01527
320389003046	HTH-like domain; Region: HTH_21; pfam13276
320389003047	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003048	Integrase core domain; Region: rve; pfam00665
320389003049	Integrase core domain; Region: rve_3; pfam13683
320389003050	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
320389003051	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
320389003052	tetrameric interface [polypeptide binding]; other site
320389003053	NAD binding site [chemical binding]; other site
320389003054	catalytic residues [active]
320389003055	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
320389003056	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389003057	inhibitor-cofactor binding pocket; inhibition site
320389003058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389003059	catalytic residue [active]
320389003060	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389003061	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389003062	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389003063	dimerization interface [polypeptide binding]; other site
320389003064	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
320389003065	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
320389003066	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
320389003067	DXD motif; other site
320389003068	acyl-CoA synthetase; Validated; Region: PRK08162
320389003069	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
320389003070	acyl-activating enzyme (AAE) consensus motif; other site
320389003071	putative active site [active]
320389003072	AMP binding site [chemical binding]; other site
320389003073	putative CoA binding site [chemical binding]; other site
320389003074	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
320389003075	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
320389003076	ligand binding site [chemical binding]; other site
320389003077	flexible hinge region; other site
320389003078	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
320389003079	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
320389003080	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389003081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389003082	DNA-binding site [nucleotide binding]; DNA binding site
320389003083	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389003084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389003085	homodimer interface [polypeptide binding]; other site
320389003086	catalytic residue [active]
320389003087	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
320389003088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389003089	NAD(P) binding site [chemical binding]; other site
320389003090	active site
320389003091	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
320389003092	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
320389003093	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
320389003094	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
320389003095	NAD binding site [chemical binding]; other site
320389003096	homotetramer interface [polypeptide binding]; other site
320389003097	homodimer interface [polypeptide binding]; other site
320389003098	substrate binding site [chemical binding]; other site
320389003099	active site
320389003100	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
320389003101	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
320389003102	active site
320389003103	FMN binding site [chemical binding]; other site
320389003104	substrate binding site [chemical binding]; other site
320389003105	homotetramer interface [polypeptide binding]; other site
320389003106	catalytic residue [active]
320389003107	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
320389003108	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
320389003109	potential catalytic triad [active]
320389003110	conserved cys residue [active]
320389003111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389003112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389003113	MASE1; Region: MASE1; pfam05231
320389003114	PAS fold; Region: PAS_3; pfam08447
320389003115	Transposase; Region: HTH_Tnp_1; pfam01527
320389003116	HTH-like domain; Region: HTH_21; pfam13276
320389003117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003118	Integrase core domain; Region: rve; pfam00665
320389003119	Integrase core domain; Region: rve_3; pfam13683
320389003120	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
320389003121	MOSC domain; Region: MOSC; pfam03473
320389003122	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
320389003123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389003124	dimer interface [polypeptide binding]; other site
320389003125	phosphorylation site [posttranslational modification]
320389003126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003127	ATP binding site [chemical binding]; other site
320389003128	Mg2+ binding site [ion binding]; other site
320389003129	G-X-G motif; other site
320389003130	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
320389003131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003132	active site
320389003133	phosphorylation site [posttranslational modification]
320389003134	intermolecular recognition site; other site
320389003135	dimerization interface [polypeptide binding]; other site
320389003136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389003137	DNA binding site [nucleotide binding]
320389003138	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
320389003139	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
320389003140	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
320389003141	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
320389003142	Walker A/P-loop; other site
320389003143	ATP binding site [chemical binding]; other site
320389003144	Q-loop/lid; other site
320389003145	ABC transporter signature motif; other site
320389003146	Walker B; other site
320389003147	D-loop; other site
320389003148	H-loop/switch region; other site
320389003149	TOBE domain; Region: TOBE_2; pfam08402
320389003150	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389003151	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389003152	trimer interface [polypeptide binding]; other site
320389003153	eyelet of channel; other site
320389003154	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
320389003155	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
320389003156	NAD(P) binding site [chemical binding]; other site
320389003157	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
320389003158	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
320389003159	putative substrate binding pocket [chemical binding]; other site
320389003160	trimer interface [polypeptide binding]; other site
320389003161	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
320389003162	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
320389003163	putative active site [active]
320389003164	putative metal binding site [ion binding]; other site
320389003165	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
320389003166	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
320389003167	NAD binding site [chemical binding]; other site
320389003168	catalytic residues [active]
320389003169	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
320389003170	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
320389003171	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
320389003172	MarR family; Region: MarR_2; cl17246
320389003173	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389003174	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389003175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389003176	NAD(P) binding site [chemical binding]; other site
320389003177	active site
320389003178	MltA-interacting protein MipA; Region: MipA; cl01504
320389003179	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389003180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003181	active site
320389003182	phosphorylation site [posttranslational modification]
320389003183	intermolecular recognition site; other site
320389003184	dimerization interface [polypeptide binding]; other site
320389003185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389003186	DNA binding site [nucleotide binding]
320389003187	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389003188	dimerization interface [polypeptide binding]; other site
320389003189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389003190	dimer interface [polypeptide binding]; other site
320389003191	phosphorylation site [posttranslational modification]
320389003192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003193	ATP binding site [chemical binding]; other site
320389003194	Mg2+ binding site [ion binding]; other site
320389003195	G-X-G motif; other site
320389003196	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
320389003197	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
320389003198	active site
320389003199	non-prolyl cis peptide bond; other site
320389003200	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
320389003201	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389003202	active site
320389003203	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
320389003204	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
320389003205	Flavin binding site [chemical binding]; other site
320389003206	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
320389003207	SnoaL-like domain; Region: SnoaL_2; pfam12680
320389003208	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
320389003209	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
320389003210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389003211	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389003212	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
320389003213	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389003214	catalytic loop [active]
320389003215	iron binding site [ion binding]; other site
320389003216	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
320389003217	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
320389003218	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
320389003219	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
320389003220	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
320389003221	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
320389003222	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
320389003223	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
320389003224	active site
320389003225	dimer interface [polypeptide binding]; other site
320389003226	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
320389003227	Ligand Binding Site [chemical binding]; other site
320389003228	Molecular Tunnel; other site
320389003229	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
320389003230	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389003231	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389003232	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389003233	DNA binding residues [nucleotide binding]
320389003234	dimerization interface [polypeptide binding]; other site
320389003235	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
320389003236	Subunit I/III interface [polypeptide binding]; other site
320389003237	Trehalase; Region: Trehalase; cl17346
320389003238	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
320389003239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003240	putative substrate translocation pore; other site
320389003241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
320389003243	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
320389003244	HTH-like domain; Region: HTH_21; pfam13276
320389003245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003246	Integrase core domain; Region: rve; pfam00665
320389003247	Integrase core domain; Region: rve_3; pfam13683
320389003248	Transposase; Region: HTH_Tnp_1; pfam01527
320389003249	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
320389003250	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
320389003251	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
320389003252	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
320389003253	hypothetical protein; Provisional; Region: PRK07907
320389003254	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
320389003255	metal binding site [ion binding]; metal-binding site
320389003256	putative dimer interface [polypeptide binding]; other site
320389003257	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
320389003258	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
320389003259	conserved cys residue [active]
320389003260	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389003261	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
320389003262	active site residue [active]
320389003263	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
320389003264	Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926
320389003265	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389003266	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389003267	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
320389003268	putative active site [active]
320389003269	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
320389003270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003271	active site
320389003272	phosphorylation site [posttranslational modification]
320389003273	intermolecular recognition site; other site
320389003274	dimerization interface [polypeptide binding]; other site
320389003275	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389003276	DNA binding site [nucleotide binding]
320389003277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389003278	dimer interface [polypeptide binding]; other site
320389003279	phosphorylation site [posttranslational modification]
320389003280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003281	ATP binding site [chemical binding]; other site
320389003282	Mg2+ binding site [ion binding]; other site
320389003283	G-X-G motif; other site
320389003284	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
320389003285	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
320389003286	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
320389003287	C-terminal domain interface [polypeptide binding]; other site
320389003288	GSH binding site (G-site) [chemical binding]; other site
320389003289	dimer interface [polypeptide binding]; other site
320389003290	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
320389003291	N-terminal domain interface [polypeptide binding]; other site
320389003292	dimer interface [polypeptide binding]; other site
320389003293	substrate binding pocket (H-site) [chemical binding]; other site
320389003294	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
320389003295	putative dimer interface [polypeptide binding]; other site
320389003296	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389003297	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
320389003298	substrate binding pocket [chemical binding]; other site
320389003299	aspartate-rich region 1; other site
320389003300	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
320389003301	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
320389003302	HD domain; Region: HD_3; pfam13023
320389003303	Cytochrome c; Region: Cytochrom_C; cl11414
320389003304	rod shape-determining protein MreB; Provisional; Region: PRK13930
320389003305	MreB and similar proteins; Region: MreB_like; cd10225
320389003306	nucleotide binding site [chemical binding]; other site
320389003307	Mg binding site [ion binding]; other site
320389003308	putative protofilament interaction site [polypeptide binding]; other site
320389003309	RodZ interaction site [polypeptide binding]; other site
320389003310	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
320389003311	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
320389003312	active site
320389003313	nucleophile elbow; other site
320389003314	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
320389003315	Surface antigen; Region: Bac_surface_Ag; pfam01103
320389003316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389003317	dimer interface [polypeptide binding]; other site
320389003318	phosphorylation site [posttranslational modification]
320389003319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003320	ATP binding site [chemical binding]; other site
320389003321	Mg2+ binding site [ion binding]; other site
320389003322	G-X-G motif; other site
320389003323	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
320389003324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003325	active site
320389003326	phosphorylation site [posttranslational modification]
320389003327	intermolecular recognition site; other site
320389003328	dimerization interface [polypeptide binding]; other site
320389003329	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389003330	DNA binding site [nucleotide binding]
320389003331	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
320389003332	glutaminase; Provisional; Region: PRK00971
320389003333	Transposase; Region: HTH_Tnp_1; pfam01527
320389003334	HTH-like domain; Region: HTH_21; pfam13276
320389003335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003336	Integrase core domain; Region: rve; pfam00665
320389003337	Integrase core domain; Region: rve_3; pfam13683
320389003338	Haemagglutinin; Region: HIM; pfam05662
320389003339	YadA-like C-terminal region; Region: YadA; pfam03895
320389003340	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
320389003341	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
320389003342	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
320389003343	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
320389003344	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
320389003345	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
320389003346	ATP-grasp domain; Region: ATP-grasp_4; cl17255
320389003347	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
320389003348	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
320389003349	carboxyltransferase (CT) interaction site; other site
320389003350	biotinylation site [posttranslational modification]; other site
320389003351	enoyl-CoA hydratase; Provisional; Region: PRK05995
320389003352	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389003353	substrate binding site [chemical binding]; other site
320389003354	oxyanion hole (OAH) forming residues; other site
320389003355	trimer interface [polypeptide binding]; other site
320389003356	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
320389003357	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
320389003358	isovaleryl-CoA dehydrogenase; Region: PLN02519
320389003359	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
320389003360	substrate binding site [chemical binding]; other site
320389003361	FAD binding site [chemical binding]; other site
320389003362	catalytic base [active]
320389003363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389003364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389003365	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
320389003366	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
320389003367	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
320389003368	Multicopper oxidase; Region: Cu-oxidase; pfam00394
320389003369	Cytochrome c; Region: Cytochrom_C; pfam00034
320389003370	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
320389003371	[2Fe-2S] cluster binding site [ion binding]; other site
320389003372	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
320389003373	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
320389003374	alpha subunit interface [polypeptide binding]; other site
320389003375	active site
320389003376	substrate binding site [chemical binding]; other site
320389003377	Fe binding site [ion binding]; other site
320389003378	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
320389003379	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
320389003380	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389003381	catalytic residue [active]
320389003382	Cupin-like domain; Region: Cupin_8; pfam13621
320389003383	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
320389003384	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
320389003385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389003386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389003387	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389003388	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
320389003389	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
320389003390	dimer interface [polypeptide binding]; other site
320389003391	phosphorylation site [posttranslational modification]
320389003392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003393	ATP binding site [chemical binding]; other site
320389003394	Mg2+ binding site [ion binding]; other site
320389003395	G-X-G motif; other site
320389003396	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389003397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003398	active site
320389003399	phosphorylation site [posttranslational modification]
320389003400	intermolecular recognition site; other site
320389003401	dimerization interface [polypeptide binding]; other site
320389003402	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389003403	DNA binding site [nucleotide binding]
320389003404	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
320389003405	ApbE family; Region: ApbE; pfam02424
320389003406	ApbE family; Region: ApbE; pfam02424
320389003407	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
320389003408	aldehyde dehydrogenase family 7 member; Region: PLN02315
320389003409	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
320389003410	tetrameric interface [polypeptide binding]; other site
320389003411	NAD binding site [chemical binding]; other site
320389003412	catalytic residues [active]
320389003413	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389003414	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389003415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389003416	homodimer interface [polypeptide binding]; other site
320389003417	catalytic residue [active]
320389003418	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
320389003419	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
320389003420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389003421	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389003422	dimerization interface [polypeptide binding]; other site
320389003423	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
320389003424	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
320389003425	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
320389003426	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389003427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389003428	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
320389003429	putative active site [active]
320389003430	catalytic site [active]
320389003431	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
320389003432	putative active site [active]
320389003433	catalytic site [active]
320389003434	PLD-like domain; Region: PLDc_2; pfam13091
320389003435	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
320389003436	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
320389003437	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
320389003438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003439	D-galactonate transporter; Region: 2A0114; TIGR00893
320389003440	putative substrate translocation pore; other site
320389003441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003442	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
320389003443	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
320389003444	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
320389003445	Transcriptional regulators [Transcription]; Region: GntR; COG1802
320389003446	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389003447	DNA-binding site [nucleotide binding]; DNA binding site
320389003448	FCD domain; Region: FCD; pfam07729
320389003449	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
320389003450	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
320389003451	metal binding site [ion binding]; metal-binding site
320389003452	substrate binding pocket [chemical binding]; other site
320389003453	putative oxidoreductase; Provisional; Region: PRK10083
320389003454	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
320389003455	putative NAD(P) binding site [chemical binding]; other site
320389003456	catalytic Zn binding site [ion binding]; other site
320389003457	structural Zn binding site [ion binding]; other site
320389003458	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
320389003459	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
320389003460	homodimer interface [polypeptide binding]; other site
320389003461	NAD binding pocket [chemical binding]; other site
320389003462	ATP binding pocket [chemical binding]; other site
320389003463	Mg binding site [ion binding]; other site
320389003464	active-site loop [active]
320389003465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389003466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389003467	hypothetical protein; Provisional; Region: PRK02399
320389003468	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
320389003469	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
320389003470	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
320389003471	putative hydrophobic ligand binding site [chemical binding]; other site
320389003472	protein interface [polypeptide binding]; other site
320389003473	gate; other site
320389003474	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
320389003475	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
320389003476	Multicopper oxidase; Region: Cu-oxidase; pfam00394
320389003477	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
320389003478	Cytochrome c; Region: Cytochrom_C; pfam00034
320389003479	Uncharacterized conserved protein [Function unknown]; Region: COG1262
320389003480	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
320389003481	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
320389003482	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
320389003483	Cu(I) binding site [ion binding]; other site
320389003484	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
320389003485	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
320389003486	amidase catalytic site [active]
320389003487	Zn binding residues [ion binding]; other site
320389003488	substrate binding site [chemical binding]; other site
320389003489	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
320389003490	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
320389003491	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389003492	trimer interface [polypeptide binding]; other site
320389003493	Haemagglutinin; Region: HIM; pfam05662
320389003494	YadA-like C-terminal region; Region: YadA; pfam03895
320389003495	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
320389003496	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
320389003497	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389003498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003499	active site
320389003500	phosphorylation site [posttranslational modification]
320389003501	intermolecular recognition site; other site
320389003502	dimerization interface [polypeptide binding]; other site
320389003503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389003504	DNA binding site [nucleotide binding]
320389003505	MASE1; Region: MASE1; cl17823
320389003506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389003507	dimer interface [polypeptide binding]; other site
320389003508	phosphorylation site [posttranslational modification]
320389003509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389003510	ATP binding site [chemical binding]; other site
320389003511	G-X-G motif; other site
320389003512	Protein of unknown function (DUF770); Region: DUF770; pfam05591
320389003513	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
320389003514	Protein of unknown function (DUF877); Region: DUF877; pfam05943
320389003515	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
320389003516	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
320389003517	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
320389003518	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
320389003519	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
320389003520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389003521	Walker A motif; other site
320389003522	ATP binding site [chemical binding]; other site
320389003523	Walker B motif; other site
320389003524	arginine finger; other site
320389003525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389003526	Walker A motif; other site
320389003527	ATP binding site [chemical binding]; other site
320389003528	Walker B motif; other site
320389003529	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
320389003530	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
320389003531	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389003532	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389003533	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212
320389003534	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389003535	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389003536	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
320389003537	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389003538	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389003539	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389003540	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389003541	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389003542	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389003543	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
320389003544	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
320389003545	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
320389003546	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
320389003547	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
320389003548	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
320389003549	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
320389003550	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
320389003551	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
320389003552	active site
320389003553	GTP cyclohydrolase I; Reviewed; Region: PRK12606
320389003554	GTP cyclohydrolase I; Provisional; Region: PLN03044
320389003555	active site
320389003556	Transposase; Region: HTH_Tnp_1; pfam01527
320389003557	HTH-like domain; Region: HTH_21; pfam13276
320389003558	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003559	Integrase core domain; Region: rve; pfam00665
320389003560	Integrase core domain; Region: rve_3; pfam13683
320389003561	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
320389003562	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
320389003563	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
320389003564	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389003565	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389003566	sequence-specific DNA binding site [nucleotide binding]; other site
320389003567	salt bridge; other site
320389003568	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
320389003569	Spore germination protein; Region: Spore_permease; cl17796
320389003570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389003571	NAD(P) binding site [chemical binding]; other site
320389003572	active site
320389003573	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
320389003574	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
320389003575	active site residue [active]
320389003576	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
320389003577	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
320389003578	catalytic Zn binding site [ion binding]; other site
320389003579	structural Zn binding site [ion binding]; other site
320389003580	NAD(P) binding site [chemical binding]; other site
320389003581	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389003582	Ligand Binding Site [chemical binding]; other site
320389003583	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389003584	Ligand Binding Site [chemical binding]; other site
320389003585	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389003586	Ligand Binding Site [chemical binding]; other site
320389003587	Transposase domain (DUF772); Region: DUF772; pfam05598
320389003588	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389003589	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389003590	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389003591	Ligand Binding Site [chemical binding]; other site
320389003592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389003593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389003594	active site
320389003595	phosphorylation site [posttranslational modification]
320389003596	intermolecular recognition site; other site
320389003597	dimerization interface [polypeptide binding]; other site
320389003598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389003599	DNA binding residues [nucleotide binding]
320389003600	dimerization interface [polypeptide binding]; other site
320389003601	Protein of unknown function (DUF2964); Region: DUF2964; pfam11177
320389003602	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
320389003603	sequence-specific DNA binding site [nucleotide binding]; other site
320389003604	salt bridge; other site
320389003605	Cupin domain; Region: Cupin_2; pfam07883
320389003606	putative monooxygenase; Reviewed; Region: PRK07045
320389003607	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
320389003608	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389003609	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
320389003610	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
320389003611	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
320389003612	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389003613	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389003614	catalytic residue [active]
320389003615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389003616	S-adenosylmethionine binding site [chemical binding]; other site
320389003617	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
320389003618	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
320389003619	substrate binding pocket [chemical binding]; other site
320389003620	active site
320389003621	iron coordination sites [ion binding]; other site
320389003622	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
320389003623	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
320389003624	putative active site pocket [active]
320389003625	dimerization interface [polypeptide binding]; other site
320389003626	putative catalytic residue [active]
320389003627	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
320389003628	MG2 domain; Region: A2M_N; pfam01835
320389003629	Alpha-2-macroglobulin family; Region: A2M; pfam00207
320389003630	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
320389003631	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
320389003632	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
320389003633	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389003634	Protein of unknown function, DUF488; Region: DUF488; cl01246
320389003635	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
320389003636	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389003637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389003638	homodimer interface [polypeptide binding]; other site
320389003639	catalytic residue [active]
320389003640	aromatic amino acid transporter; Provisional; Region: PRK10238
320389003641	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389003642	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
320389003643	AsnC family; Region: AsnC_trans_reg; pfam01037
320389003644	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
320389003645	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
320389003646	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
320389003647	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389003648	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389003649	metal binding site [ion binding]; metal-binding site
320389003650	active site
320389003651	I-site; other site
320389003652	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
320389003653	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
320389003654	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
320389003655	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
320389003656	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
320389003657	dimerization interface [polypeptide binding]; other site
320389003658	ligand binding site [chemical binding]; other site
320389003659	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
320389003660	CoenzymeA binding site [chemical binding]; other site
320389003661	subunit interaction site [polypeptide binding]; other site
320389003662	PHB binding site; other site
320389003663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389003664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389003665	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
320389003666	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
320389003667	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389003668	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389003669	H-NS histone family; Region: Histone_HNS; pfam00816
320389003670	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389003671	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
320389003672	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389003673	trimer interface [polypeptide binding]; other site
320389003674	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389003675	YadA-like C-terminal region; Region: YadA; pfam03895
320389003676	Transposase; Region: HTH_Tnp_1; pfam01527
320389003677	HTH-like domain; Region: HTH_21; pfam13276
320389003678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003679	Integrase core domain; Region: rve; pfam00665
320389003680	Integrase core domain; Region: rve_3; pfam13683
320389003681	Domain of unknown function (DUF718); Region: DUF718; cl01281
320389003682	short chain dehydrogenase; Provisional; Region: PRK08628
320389003683	classical (c) SDRs; Region: SDR_c; cd05233
320389003684	NAD(P) binding site [chemical binding]; other site
320389003685	active site
320389003686	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
320389003687	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
320389003688	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
320389003689	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
320389003690	NAD binding site [chemical binding]; other site
320389003691	homotetramer interface [polypeptide binding]; other site
320389003692	homodimer interface [polypeptide binding]; other site
320389003693	active site
320389003694	Amidohydrolase; Region: Amidohydro_2; pfam04909
320389003695	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
320389003696	active site
320389003697	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
320389003698	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
320389003699	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
320389003700	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389003701	TM-ABC transporter signature motif; other site
320389003702	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
320389003703	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
320389003704	Walker A/P-loop; other site
320389003705	ATP binding site [chemical binding]; other site
320389003706	Q-loop/lid; other site
320389003707	ABC transporter signature motif; other site
320389003708	Walker B; other site
320389003709	D-loop; other site
320389003710	H-loop/switch region; other site
320389003711	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
320389003712	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
320389003713	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
320389003714	ligand binding site [chemical binding]; other site
320389003715	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389003716	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
320389003717	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389003718	Tannase and feruloyl esterase; Region: Tannase; pfam07519
320389003719	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389003720	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389003721	trimer interface [polypeptide binding]; other site
320389003722	eyelet of channel; other site
320389003723	transcription termination factor Rho; Provisional; Region: PRK12678
320389003724	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
320389003725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003726	putative substrate translocation pore; other site
320389003727	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389003728	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389003729	NAD(P) binding site [chemical binding]; other site
320389003730	catalytic residues [active]
320389003731	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
320389003732	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389003733	substrate binding site [chemical binding]; other site
320389003734	oxyanion hole (OAH) forming residues; other site
320389003735	trimer interface [polypeptide binding]; other site
320389003736	Uncharacterized conserved protein [Function unknown]; Region: COG5649
320389003737	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
320389003738	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
320389003739	MarR family; Region: MarR_2; cl17246
320389003740	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389003741	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389003742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
320389003743	active site
320389003744	phosphorylation site [posttranslational modification]
320389003745	intermolecular recognition site; other site
320389003746	dimerization interface [polypeptide binding]; other site
320389003747	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389003748	DNA binding residues [nucleotide binding]
320389003749	dimerization interface [polypeptide binding]; other site
320389003750	Phosphoesterase family; Region: Phosphoesterase; pfam04185
320389003751	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
320389003752	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
320389003753	H-type lectin domain; Region: H_lectin; pfam09458
320389003754	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
320389003755	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
320389003756	putative ion selectivity filter; other site
320389003757	putative pore gating glutamate residue; other site
320389003758	short chain dehydrogenase; Provisional; Region: PRK12829
320389003759	classical (c) SDRs; Region: SDR_c; cd05233
320389003760	NAD(P) binding site [chemical binding]; other site
320389003761	active site
320389003762	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
320389003763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003764	putative substrate translocation pore; other site
320389003765	cytosine deaminase; Provisional; Region: PRK09230
320389003766	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
320389003767	active site
320389003768	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
320389003769	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
320389003770	cytosine permease; Provisional; Region: codB; PRK11017
320389003771	Na binding site [ion binding]; other site
320389003772	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
320389003773	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389003774	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389003775	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389003776	trimer interface [polypeptide binding]; other site
320389003777	eyelet of channel; other site
320389003778	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389003779	transcriptional regulator; Provisional; Region: PRK10632
320389003780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389003781	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389003782	putative effector binding pocket; other site
320389003783	dimerization interface [polypeptide binding]; other site
320389003784	Fusaric acid resistance protein family; Region: FUSC; pfam04632
320389003785	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
320389003786	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
320389003787	homodimer interface [polypeptide binding]; other site
320389003788	homotetramer interface [polypeptide binding]; other site
320389003789	active site pocket [active]
320389003790	cleavage site
320389003791	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
320389003792	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389003793	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389003794	DNA binding residues [nucleotide binding]
320389003795	dimerization interface [polypeptide binding]; other site
320389003796	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
320389003797	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
320389003798	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389003799	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389003800	trimer interface [polypeptide binding]; other site
320389003801	eyelet of channel; other site
320389003802	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389003803	Secretory lipase; Region: LIP; pfam03583
320389003804	HTH-like domain; Region: HTH_21; pfam13276
320389003805	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003806	Integrase core domain; Region: rve; pfam00665
320389003807	Integrase core domain; Region: rve_3; pfam13683
320389003808	Transposase; Region: HTH_Tnp_1; pfam01527
320389003809	Cupin domain; Region: Cupin_2; cl17218
320389003810	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
320389003811	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
320389003812	Transcriptional regulators [Transcription]; Region: FadR; COG2186
320389003813	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389003814	DNA-binding site [nucleotide binding]; DNA binding site
320389003815	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
320389003816	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
320389003817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
320389003818	putative aldolase; Validated; Region: PRK08130
320389003819	intersubunit interface [polypeptide binding]; other site
320389003820	active site
320389003821	Zn2+ binding site [ion binding]; other site
320389003822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389003823	D-galactonate transporter; Region: 2A0114; TIGR00893
320389003824	putative substrate translocation pore; other site
320389003825	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
320389003826	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389003827	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
320389003828	putative NAD(P) binding site [chemical binding]; other site
320389003829	active site
320389003830	putative substrate binding site [chemical binding]; other site
320389003831	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
320389003832	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
320389003833	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
320389003834	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
320389003835	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
320389003836	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
320389003837	conserved cys residue [active]
320389003838	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389003839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389003840	dimer interface [polypeptide binding]; other site
320389003841	conserved gate region; other site
320389003842	putative PBP binding loops; other site
320389003843	ABC-ATPase subunit interface; other site
320389003844	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
320389003845	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
320389003846	Walker A/P-loop; other site
320389003847	ATP binding site [chemical binding]; other site
320389003848	Q-loop/lid; other site
320389003849	ABC transporter signature motif; other site
320389003850	Walker B; other site
320389003851	D-loop; other site
320389003852	H-loop/switch region; other site
320389003853	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
320389003854	Predicted flavoprotein [General function prediction only]; Region: COG0431
320389003855	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
320389003856	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
320389003857	putative metal binding site [ion binding]; other site
320389003858	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
320389003859	Low molecular weight phosphatase family; Region: LMWPc; cd00115
320389003860	active site
320389003861	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
320389003862	arsenical-resistance protein; Region: acr3; TIGR00832
320389003863	Transposase; Region: HTH_Tnp_1; pfam01527
320389003864	HTH-like domain; Region: HTH_21; pfam13276
320389003865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003866	Integrase core domain; Region: rve; pfam00665
320389003867	Integrase core domain; Region: rve_3; pfam13683
320389003868	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
320389003869	Bacterial Ig-like domain; Region: Big_5; pfam13205
320389003870	Integrase core domain; Region: rve; pfam00665
320389003871	Integrase core domain; Region: rve_3; pfam13683
320389003872	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
320389003873	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
320389003874	putative active site [active]
320389003875	catalytic site [active]
320389003876	putative metal binding site [ion binding]; other site
320389003877	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
320389003878	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389003879	active site
320389003880	metal binding site [ion binding]; metal-binding site
320389003881	HTH-like domain; Region: HTH_21; pfam13276
320389003882	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389003883	Integrase core domain; Region: rve; pfam00665
320389003884	Integrase core domain; Region: rve_3; pfam13683
320389003885	Transposase; Region: HTH_Tnp_1; pfam01527
320389003886	enoyl-CoA hydratase; Provisional; Region: PRK05862
320389003887	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389003888	substrate binding site [chemical binding]; other site
320389003889	oxyanion hole (OAH) forming residues; other site
320389003890	trimer interface [polypeptide binding]; other site
320389003891	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
320389003892	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389003893	NAD(P) binding site [chemical binding]; other site
320389003894	catalytic residues [active]
320389003895	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
320389003896	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389003897	dimer interface [polypeptide binding]; other site
320389003898	active site
320389003899	enoyl-CoA hydratase; Provisional; Region: PRK08140
320389003900	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389003901	substrate binding site [chemical binding]; other site
320389003902	oxyanion hole (OAH) forming residues; other site
320389003903	trimer interface [polypeptide binding]; other site
320389003904	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
320389003905	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
320389003906	active site
320389003907	AMP binding site [chemical binding]; other site
320389003908	homodimer interface [polypeptide binding]; other site
320389003909	acyl-activating enzyme (AAE) consensus motif; other site
320389003910	CoA binding site [chemical binding]; other site
320389003911	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
320389003912	MltA specific insert domain; Region: MltA; smart00925
320389003913	3D domain; Region: 3D; pfam06725
320389003914	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
320389003915	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
320389003916	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
320389003917	substrate binding site [chemical binding]; other site
320389003918	hexamer interface [polypeptide binding]; other site
320389003919	metal binding site [ion binding]; metal-binding site
320389003920	phosphoglycolate phosphatase; Provisional; Region: PRK13222
320389003921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389003922	motif II; other site
320389003923	anthranilate synthase component I; Provisional; Region: PRK13565
320389003924	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
320389003925	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
320389003926	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
320389003927	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
320389003928	glutamine binding [chemical binding]; other site
320389003929	catalytic triad [active]
320389003930	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
320389003931	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
320389003932	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
320389003933	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
320389003934	active site
320389003935	ribulose/triose binding site [chemical binding]; other site
320389003936	phosphate binding site [ion binding]; other site
320389003937	substrate (anthranilate) binding pocket [chemical binding]; other site
320389003938	product (indole) binding pocket [chemical binding]; other site
320389003939	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
320389003940	putative active site [active]
320389003941	putative metal binding residues [ion binding]; other site
320389003942	signature motif; other site
320389003943	putative triphosphate binding site [ion binding]; other site
320389003944	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
320389003945	ligand binding site [chemical binding]; other site
320389003946	active site
320389003947	UGI interface [polypeptide binding]; other site
320389003948	catalytic site [active]
320389003949	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
320389003950	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
320389003951	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
320389003952	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
320389003953	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
320389003954	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
320389003955	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
320389003956	dimerization domain [polypeptide binding]; other site
320389003957	dimer interface [polypeptide binding]; other site
320389003958	catalytic residues [active]
320389003959	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
320389003960	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
320389003961	GTP-binding protein YchF; Reviewed; Region: PRK09601
320389003962	YchF GTPase; Region: YchF; cd01900
320389003963	G1 box; other site
320389003964	GTP/Mg2+ binding site [chemical binding]; other site
320389003965	Switch I region; other site
320389003966	G2 box; other site
320389003967	Switch II region; other site
320389003968	G3 box; other site
320389003969	G4 box; other site
320389003970	G5 box; other site
320389003971	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
320389003972	NADH dehydrogenase subunit B; Validated; Region: PRK06411
320389003973	Helix-turn-helix domain; Region: HTH_18; pfam12833
320389003974	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
320389003975	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
320389003976	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
320389003977	putative active site [active]
320389003978	catalytic site [active]
320389003979	putative metal binding site [ion binding]; other site
320389003980	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
320389003981	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
320389003982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389003983	Walker A/P-loop; other site
320389003984	ATP binding site [chemical binding]; other site
320389003985	Q-loop/lid; other site
320389003986	ABC transporter signature motif; other site
320389003987	Walker B; other site
320389003988	D-loop; other site
320389003989	H-loop/switch region; other site
320389003990	ABC transporter; Region: ABC_tran_2; pfam12848
320389003991	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389003992	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
320389003993	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
320389003994	Isochorismatase family; Region: Isochorismatase; pfam00857
320389003995	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
320389003996	catalytic triad [active]
320389003997	conserved cis-peptide bond; other site
320389003998	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
320389003999	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
320389004000	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
320389004001	active site
320389004002	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
320389004003	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
320389004004	tRNA; other site
320389004005	putative tRNA binding site [nucleotide binding]; other site
320389004006	putative NADP binding site [chemical binding]; other site
320389004007	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
320389004008	peptide chain release factor 1; Validated; Region: prfA; PRK00591
320389004009	This domain is found in peptide chain release factors; Region: PCRF; smart00937
320389004010	RF-1 domain; Region: RF-1; pfam00472
320389004011	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
320389004012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389004013	S-adenosylmethionine binding site [chemical binding]; other site
320389004014	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
320389004015	putative GSH binding site [chemical binding]; other site
320389004016	catalytic residues [active]
320389004017	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
320389004018	Flavoprotein; Region: Flavoprotein; pfam02441
320389004019	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
320389004020	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
320389004021	putative active site [active]
320389004022	metal binding site [ion binding]; metal-binding site
320389004023	amino acid transporter; Region: 2A0306; TIGR00909
320389004024	HTH-like domain; Region: HTH_21; pfam13276
320389004025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389004026	Integrase core domain; Region: rve; pfam00665
320389004027	Integrase core domain; Region: rve_3; pfam13683
320389004028	Transposase; Region: HTH_Tnp_1; pfam01527
320389004029	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
320389004030	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
320389004031	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
320389004032	active site
320389004033	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
320389004034	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
320389004035	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389004036	Uncharacterized conserved protein [Function unknown]; Region: COG3246
320389004037	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
320389004038	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
320389004039	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
320389004040	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
320389004041	conserved cys residue [active]
320389004042	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389004043	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
320389004044	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
320389004045	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
320389004046	Zn binding site [ion binding]; other site
320389004047	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
320389004048	Peptidase family M28; Region: Peptidase_M28; pfam04389
320389004049	active site
320389004050	metal binding site [ion binding]; metal-binding site
320389004051	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389004052	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389004053	trimer interface [polypeptide binding]; other site
320389004054	eyelet of channel; other site
320389004055	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
320389004056	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
320389004057	choline-sulfatase; Region: chol_sulfatase; TIGR03417
320389004058	Sulfatase; Region: Sulfatase; cl17466
320389004059	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
320389004060	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
320389004061	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004062	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
320389004063	substrate binding pocket [chemical binding]; other site
320389004064	dimerization interface [polypeptide binding]; other site
320389004065	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
320389004066	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
320389004067	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
320389004068	putative active site [active]
320389004069	putative substrate binding site [chemical binding]; other site
320389004070	putative cosubstrate binding site; other site
320389004071	catalytic site [active]
320389004072	Amino acid permease; Region: AA_permease_2; pfam13520
320389004073	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
320389004074	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
320389004075	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
320389004076	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
320389004077	FAD binding pocket [chemical binding]; other site
320389004078	FAD binding motif [chemical binding]; other site
320389004079	phosphate binding motif [ion binding]; other site
320389004080	beta-alpha-beta structure motif; other site
320389004081	NAD binding pocket [chemical binding]; other site
320389004082	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
320389004083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389004084	catalytic loop [active]
320389004085	iron binding site [ion binding]; other site
320389004086	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
320389004087	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
320389004088	[2Fe-2S] cluster binding site [ion binding]; other site
320389004089	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
320389004090	putative alpha subunit interface [polypeptide binding]; other site
320389004091	putative active site [active]
320389004092	putative substrate binding site [chemical binding]; other site
320389004093	Fe binding site [ion binding]; other site
320389004094	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
320389004095	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
320389004096	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
320389004097	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
320389004098	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
320389004099	Cysteine-rich domain; Region: CCG; pfam02754
320389004100	Cysteine-rich domain; Region: CCG; pfam02754
320389004101	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
320389004102	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
320389004103	putative active site [active]
320389004104	putative FMN binding site [chemical binding]; other site
320389004105	putative substrate binding site [chemical binding]; other site
320389004106	putative catalytic residue [active]
320389004107	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
320389004108	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
320389004109	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
320389004110	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
320389004111	active site
320389004112	dimer interface [polypeptide binding]; other site
320389004113	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
320389004114	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
320389004115	dimer interface [polypeptide binding]; other site
320389004116	active site
320389004117	glycine-pyridoxal phosphate binding site [chemical binding]; other site
320389004118	folate binding site [chemical binding]; other site
320389004119	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
320389004120	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
320389004121	conserved cys residue [active]
320389004122	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389004123	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
320389004124	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
320389004125	NAD binding site [chemical binding]; other site
320389004126	catalytic Zn binding site [ion binding]; other site
320389004127	structural Zn binding site [ion binding]; other site
320389004128	Transcriptional regulators [Transcription]; Region: PurR; COG1609
320389004129	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
320389004130	DNA binding site [nucleotide binding]
320389004131	domain linker motif; other site
320389004132	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
320389004133	ligand binding site [chemical binding]; other site
320389004134	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
320389004135	active site
320389004136	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
320389004137	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
320389004138	substrate binding [chemical binding]; other site
320389004139	active site
320389004140	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
320389004141	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
320389004142	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389004143	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389004144	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
320389004145	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
320389004146	Ligand binding site; other site
320389004147	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389004148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389004149	putative substrate translocation pore; other site
320389004150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389004151	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
320389004152	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
320389004153	active site
320389004154	TDP-binding site; other site
320389004155	acceptor substrate-binding pocket; other site
320389004156	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389004157	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
320389004158	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
320389004159	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
320389004160	hypothetical protein; Provisional; Region: PRK14693
320389004161	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
320389004162	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389004163	ligand binding site [chemical binding]; other site
320389004164	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
320389004165	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
320389004166	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
320389004167	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389004168	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
320389004169	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389004170	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212
320389004171	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389004172	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
320389004173	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
320389004174	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389004175	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389004176	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
320389004177	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389004178	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389004179	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
320389004180	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
320389004181	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
320389004182	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
320389004183	Protein of unknown function (DUF796); Region: DUF796; pfam05638
320389004184	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
320389004185	Protein of unknown function (DUF877); Region: DUF877; pfam05943
320389004186	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
320389004187	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
320389004188	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
320389004189	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
320389004190	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
320389004191	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
320389004192	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
320389004193	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
320389004194	putative membrane protein; Region: HpnL; TIGR03476
320389004195	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
320389004196	active site
320389004197	metal-binding site
320389004198	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
320389004199	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
320389004200	tetramer interface [polypeptide binding]; other site
320389004201	active site
320389004202	Mg2+/Mn2+ binding site [ion binding]; other site
320389004203	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
320389004204	active site
320389004205	metal-binding site
320389004206	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389004207	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389004208	catalytic residue [active]
320389004209	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
320389004210	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
320389004211	conserved cys residue [active]
320389004212	Predicted membrane protein [Function unknown]; Region: COG1289
320389004213	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
320389004214	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
320389004215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389004216	putative substrate translocation pore; other site
320389004217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389004218	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389004219	DNA-binding site [nucleotide binding]; DNA binding site
320389004220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389004221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389004222	homodimer interface [polypeptide binding]; other site
320389004223	catalytic residue [active]
320389004224	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
320389004225	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
320389004226	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
320389004227	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
320389004228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
320389004229	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
320389004230	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
320389004231	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
320389004232	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
320389004233	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
320389004234	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
320389004235	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
320389004236	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
320389004237	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
320389004238	Transglutaminase/protease-like homologues; Region: TGc; smart00460
320389004239	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
320389004240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
320389004241	Uncharacterized conserved protein [Function unknown]; Region: COG2308
320389004242	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
320389004243	putative FMN binding site [chemical binding]; other site
320389004244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
320389004245	Chitin binding domain; Region: Chitin_bind_3; pfam03067
320389004246	peroxiredoxin; Region: AhpC; TIGR03137
320389004247	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
320389004248	dimer interface [polypeptide binding]; other site
320389004249	decamer (pentamer of dimers) interface [polypeptide binding]; other site
320389004250	catalytic triad [active]
320389004251	peroxidatic and resolving cysteines [active]
320389004252	Transposase; Region: HTH_Tnp_1; pfam01527
320389004253	HTH-like domain; Region: HTH_21; pfam13276
320389004254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389004255	Integrase core domain; Region: rve; pfam00665
320389004256	Integrase core domain; Region: rve_3; pfam13683
320389004257	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
320389004258	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
320389004259	acetyl-CoA synthetase; Provisional; Region: PRK00174
320389004260	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
320389004261	active site
320389004262	CoA binding site [chemical binding]; other site
320389004263	acyl-activating enzyme (AAE) consensus motif; other site
320389004264	AMP binding site [chemical binding]; other site
320389004265	acetate binding site [chemical binding]; other site
320389004266	hypothetical protein; Provisional; Region: PRK05208
320389004267	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
320389004268	Fumarase C-terminus; Region: Fumerase_C; pfam05683
320389004269	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
320389004270	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
320389004271	heme binding site [chemical binding]; other site
320389004272	ferroxidase pore; other site
320389004273	ferroxidase diiron center [ion binding]; other site
320389004274	glutamate racemase; Provisional; Region: PRK00865
320389004275	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
320389004276	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
320389004277	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
320389004278	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
320389004279	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
320389004280	Transposase domain (DUF772); Region: DUF772; pfam05598
320389004281	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389004282	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389004283	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
320389004284	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
320389004285	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
320389004286	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256
320389004287	putative NAD(P) binding site [chemical binding]; other site
320389004288	catalytic Zn binding site [ion binding]; other site
320389004289	structural Zn binding site [ion binding]; other site
320389004290	short chain dehydrogenase; Provisional; Region: PRK06841
320389004291	classical (c) SDRs; Region: SDR_c; cd05233
320389004292	NAD(P) binding site [chemical binding]; other site
320389004293	active site
320389004294	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
320389004295	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
320389004296	putative ligand binding site [chemical binding]; other site
320389004297	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389004298	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
320389004299	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
320389004300	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
320389004301	Walker A/P-loop; other site
320389004302	ATP binding site [chemical binding]; other site
320389004303	Q-loop/lid; other site
320389004304	ABC transporter signature motif; other site
320389004305	Walker B; other site
320389004306	D-loop; other site
320389004307	H-loop/switch region; other site
320389004308	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
320389004309	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
320389004310	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
320389004311	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
320389004312	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
320389004313	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389004314	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389004315	trimer interface [polypeptide binding]; other site
320389004316	eyelet of channel; other site
320389004317	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
320389004318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389004319	dimer interface [polypeptide binding]; other site
320389004320	conserved gate region; other site
320389004321	putative PBP binding loops; other site
320389004322	ABC-ATPase subunit interface; other site
320389004323	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
320389004324	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
320389004325	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
320389004326	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
320389004327	Walker A/P-loop; other site
320389004328	ATP binding site [chemical binding]; other site
320389004329	Q-loop/lid; other site
320389004330	ABC transporter signature motif; other site
320389004331	Walker B; other site
320389004332	D-loop; other site
320389004333	H-loop/switch region; other site
320389004334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389004335	dimer interface [polypeptide binding]; other site
320389004336	conserved gate region; other site
320389004337	putative PBP binding loops; other site
320389004338	ABC-ATPase subunit interface; other site
320389004339	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
320389004340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004341	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389004342	dimerization interface [polypeptide binding]; other site
320389004343	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
320389004344	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389004345	N-terminal plug; other site
320389004346	ligand-binding site [chemical binding]; other site
320389004347	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
320389004348	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
320389004349	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
320389004350	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
320389004351	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
320389004352	intersubunit interface [polypeptide binding]; other site
320389004353	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
320389004354	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
320389004355	putative PBP binding regions; other site
320389004356	ABC-ATPase subunit  interface; other site
320389004357	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547
320389004358	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
320389004359	Walker A/P-loop; other site
320389004360	ATP binding site [chemical binding]; other site
320389004361	Q-loop/lid; other site
320389004362	ABC transporter signature motif; other site
320389004363	Walker B; other site
320389004364	D-loop; other site
320389004365	H-loop/switch region; other site
320389004366	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
320389004367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004368	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
320389004369	putative dimerization interface [polypeptide binding]; other site
320389004370	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
320389004371	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
320389004372	tetramer interface [polypeptide binding]; other site
320389004373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389004374	catalytic residue [active]
320389004375	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
320389004376	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
320389004377	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
320389004378	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
320389004379	active site lid residues [active]
320389004380	substrate binding pocket [chemical binding]; other site
320389004381	catalytic residues [active]
320389004382	substrate-Mg2+ binding site; other site
320389004383	aspartate-rich region 1; other site
320389004384	aspartate-rich region 2; other site
320389004385	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389004386	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
320389004387	active site
320389004388	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
320389004389	Sulfatase; Region: Sulfatase; cl17466
320389004390	Sulfatase; Region: Sulfatase; cl17466
320389004391	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
320389004392	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
320389004393	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
320389004394	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
320389004395	Uncharacterized conserved protein [Function unknown]; Region: COG5361
320389004396	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
320389004397	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
320389004398	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
320389004399	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
320389004400	Protein of unknown function (DUF4087); Region: DUF4087; pfam13316
320389004401	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
320389004402	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389004403	Coenzyme A binding pocket [chemical binding]; other site
320389004404	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
320389004405	MgtC family; Region: MgtC; pfam02308
320389004406	dimerization interface [polypeptide binding]; other site
320389004407	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
320389004408	putative active cleft [active]
320389004409	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
320389004410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004411	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
320389004412	dimerization interface [polypeptide binding]; other site
320389004413	substrate binding pocket [chemical binding]; other site
320389004414	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
320389004415	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
320389004416	dimer interface [polypeptide binding]; other site
320389004417	ligand binding site [chemical binding]; other site
320389004418	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389004419	dimer interface [polypeptide binding]; other site
320389004420	putative CheW interface [polypeptide binding]; other site
320389004421	Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913
320389004422	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389004423	FeS/SAM binding site; other site
320389004424	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
320389004425	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
320389004426	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
320389004427	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
320389004428	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
320389004429	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
320389004430	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
320389004431	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
320389004432	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
320389004433	substrate binding site [chemical binding]; other site
320389004434	ligand binding site [chemical binding]; other site
320389004435	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
320389004436	substrate binding site [chemical binding]; other site
320389004437	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
320389004438	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
320389004439	dimer interface [polypeptide binding]; other site
320389004440	active site
320389004441	citrylCoA binding site [chemical binding]; other site
320389004442	oxalacetate/citrate binding site [chemical binding]; other site
320389004443	coenzyme A binding site [chemical binding]; other site
320389004444	catalytic triad [active]
320389004445	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
320389004446	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
320389004447	tetramer interface [polypeptide binding]; other site
320389004448	active site
320389004449	Mg2+/Mn2+ binding site [ion binding]; other site
320389004450	Propionate catabolism activator; Region: PrpR_N; pfam06506
320389004451	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389004452	putative active site [active]
320389004453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389004454	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
320389004455	Walker A motif; other site
320389004456	ATP binding site [chemical binding]; other site
320389004457	Walker B motif; other site
320389004458	arginine finger; other site
320389004459	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389004460	dimerization interface [polypeptide binding]; other site
320389004461	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389004462	dimer interface [polypeptide binding]; other site
320389004463	putative CheW interface [polypeptide binding]; other site
320389004464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389004465	S-adenosylmethionine binding site [chemical binding]; other site
320389004466	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
320389004467	TAP-like protein; Region: Abhydrolase_4; pfam08386
320389004468	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
320389004469	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
320389004470	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
320389004471	active site
320389004472	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389004473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004474	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
320389004475	putative substrate binding pocket [chemical binding]; other site
320389004476	dimerization interface [polypeptide binding]; other site
320389004477	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664
320389004478	putative active site [active]
320389004479	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
320389004480	carboxyltransferase (CT) interaction site; other site
320389004481	biotinylation site [posttranslational modification]; other site
320389004482	acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833
320389004483	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
320389004484	ATP-grasp domain; Region: ATP-grasp_4; cl17255
320389004485	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
320389004486	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
320389004487	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
320389004488	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
320389004489	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
320389004490	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389004491	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
320389004492	dimer interface [polypeptide binding]; other site
320389004493	putative metal binding site [ion binding]; other site
320389004494	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
320389004495	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
320389004496	homodimer interface [polypeptide binding]; other site
320389004497	substrate-cofactor binding pocket; other site
320389004498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389004499	catalytic residue [active]
320389004500	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
320389004501	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
320389004502	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389004503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004504	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
320389004505	putative substrate binding pocket [chemical binding]; other site
320389004506	putative dimerization interface [polypeptide binding]; other site
320389004507	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
320389004508	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
320389004509	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
320389004510	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
320389004511	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389004512	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
320389004513	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389004514	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389004515	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
320389004516	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
320389004517	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389004518	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389004519	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
320389004520	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
320389004521	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
320389004522	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
320389004523	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
320389004524	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
320389004525	ImpE protein; Region: ImpE; pfam07024
320389004526	Protein of unknown function (DUF770); Region: DUF770; pfam05591
320389004527	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
320389004528	Protein of unknown function (DUF877); Region: DUF877; pfam05943
320389004529	Protein of unknown function (DUF796); Region: DUF796; pfam05638
320389004530	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
320389004531	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
320389004532	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
320389004533	hypothetical protein; Provisional; Region: PRK08126
320389004534	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
320389004535	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389004536	ligand binding site [chemical binding]; other site
320389004537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389004538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004539	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389004540	putative effector binding pocket; other site
320389004541	dimerization interface [polypeptide binding]; other site
320389004542	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
320389004543	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
320389004544	NADP binding site [chemical binding]; other site
320389004545	dimer interface [polypeptide binding]; other site
320389004546	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
320389004547	active site
320389004548	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
320389004549	dimer interface [polypeptide binding]; other site
320389004550	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
320389004551	Ligand Binding Site [chemical binding]; other site
320389004552	Molecular Tunnel; other site
320389004553	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
320389004554	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
320389004555	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
320389004556	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
320389004557	substrate binding pocket [chemical binding]; other site
320389004558	active site
320389004559	iron coordination sites [ion binding]; other site
320389004560	Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207
320389004561	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
320389004562	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389004563	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389004564	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
320389004565	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
320389004566	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
320389004567	SnoaL-like domain; Region: SnoaL_2; pfam12680
320389004568	short chain dehydrogenase; Provisional; Region: PRK07023
320389004569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389004570	NAD(P) binding site [chemical binding]; other site
320389004571	active site
320389004572	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389004573	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004574	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389004575	dimerization interface [polypeptide binding]; other site
320389004576	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
320389004577	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
320389004578	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
320389004579	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389004580	substrate binding pocket [chemical binding]; other site
320389004581	membrane-bound complex binding site; other site
320389004582	hinge residues; other site
320389004583	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
320389004584	putative di-iron ligands [ion binding]; other site
320389004585	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
320389004586	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
320389004587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004588	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389004589	dimerization interface [polypeptide binding]; other site
320389004590	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
320389004591	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
320389004592	metal binding site [ion binding]; metal-binding site
320389004593	putative dimer interface [polypeptide binding]; other site
320389004594	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389004595	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389004596	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
320389004597	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
320389004598	ATP binding site [chemical binding]; other site
320389004599	Mg++ binding site [ion binding]; other site
320389004600	motif III; other site
320389004601	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389004602	nucleotide binding region [chemical binding]; other site
320389004603	ATP-binding site [chemical binding]; other site
320389004604	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
320389004605	putative RNA binding site [nucleotide binding]; other site
320389004606	Transposase; Region: HTH_Tnp_1; pfam01527
320389004607	HTH-like domain; Region: HTH_21; pfam13276
320389004608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389004609	Integrase core domain; Region: rve; pfam00665
320389004610	Integrase core domain; Region: rve_3; pfam13683
320389004611	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389004612	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
320389004613	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389004614	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
320389004615	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389004616	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389004617	trimer interface [polypeptide binding]; other site
320389004618	eyelet of channel; other site
320389004619	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
320389004620	2-methylcitrate dehydratase; Region: prpD; TIGR02330
320389004621	OpgC protein; Region: OpgC_C; pfam10129
320389004622	Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Region: DBF4; COG5067
320389004623	Predicted permeases [General function prediction only]; Region: RarD; COG2962
320389004624	acylphosphatase; Provisional; Region: PRK14424
320389004625	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
320389004626	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
320389004627	putative NADP binding site [chemical binding]; other site
320389004628	putative substrate binding site [chemical binding]; other site
320389004629	active site
320389004630	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
320389004631	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
320389004632	active site
320389004633	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
320389004634	LytB protein; Region: LYTB; pfam02401
320389004635	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
320389004636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389004637	FeS/SAM binding site; other site
320389004638	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
320389004639	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
320389004640	aminotransferase; Validated; Region: PRK07046
320389004641	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389004642	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389004643	catalytic residue [active]
320389004644	Transposase domain (DUF772); Region: DUF772; pfam05598
320389004645	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389004646	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389004647	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
320389004648	short chain dehydrogenase; Provisional; Region: PRK06701
320389004649	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
320389004650	NAD binding site [chemical binding]; other site
320389004651	metal binding site [ion binding]; metal-binding site
320389004652	active site
320389004653	short chain dehydrogenase; Provisional; Region: PRK07109
320389004654	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
320389004655	putative NAD(P) binding site [chemical binding]; other site
320389004656	active site
320389004657	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
320389004658	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
320389004659	putative ADP-binding pocket [chemical binding]; other site
320389004660	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
320389004661	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389004662	NAD binding site [chemical binding]; other site
320389004663	putative substrate binding site 2 [chemical binding]; other site
320389004664	putative substrate binding site 1 [chemical binding]; other site
320389004665	active site
320389004666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389004667	PAS domain; Region: PAS_9; pfam13426
320389004668	putative active site [active]
320389004669	heme pocket [chemical binding]; other site
320389004670	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
320389004671	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389004672	putative active site [active]
320389004673	heme pocket [chemical binding]; other site
320389004674	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389004675	dimer interface [polypeptide binding]; other site
320389004676	phosphorylation site [posttranslational modification]
320389004677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389004678	ATP binding site [chemical binding]; other site
320389004679	Mg2+ binding site [ion binding]; other site
320389004680	G-X-G motif; other site
320389004681	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
320389004682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389004683	active site
320389004684	phosphorylation site [posttranslational modification]
320389004685	intermolecular recognition site; other site
320389004686	dimerization interface [polypeptide binding]; other site
320389004687	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
320389004688	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
320389004689	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
320389004690	active site
320389004691	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389004692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389004693	active site
320389004694	phosphorylation site [posttranslational modification]
320389004695	intermolecular recognition site; other site
320389004696	dimerization interface [polypeptide binding]; other site
320389004697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389004698	Walker A motif; other site
320389004699	ATP binding site [chemical binding]; other site
320389004700	Walker B motif; other site
320389004701	arginine finger; other site
320389004702	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389004703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389004704	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
320389004705	Walker A motif; other site
320389004706	ATP binding site [chemical binding]; other site
320389004707	Walker B motif; other site
320389004708	arginine finger; other site
320389004709	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
320389004710	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389004711	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389004712	putative active site [active]
320389004713	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
320389004714	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
320389004715	active site
320389004716	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
320389004717	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
320389004718	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389004719	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389004720	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389004721	putative active site [active]
320389004722	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
320389004723	classical (c) SDRs; Region: SDR_c; cd05233
320389004724	NAD(P) binding site [chemical binding]; other site
320389004725	active site
320389004726	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
320389004727	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
320389004728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389004729	Walker A/P-loop; other site
320389004730	ATP binding site [chemical binding]; other site
320389004731	Q-loop/lid; other site
320389004732	ABC transporter signature motif; other site
320389004733	Walker B; other site
320389004734	D-loop; other site
320389004735	H-loop/switch region; other site
320389004736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
320389004737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389004738	Response regulator receiver domain; Region: Response_reg; pfam00072
320389004739	active site
320389004740	phosphorylation site [posttranslational modification]
320389004741	intermolecular recognition site; other site
320389004742	dimerization interface [polypeptide binding]; other site
320389004743	BON domain; Region: BON; pfam04972
320389004744	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
320389004745	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
320389004746	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575
320389004747	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
320389004748	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
320389004749	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
320389004750	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
320389004751	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
320389004752	active site
320389004753	non-prolyl cis peptide bond; other site
320389004754	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
320389004755	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
320389004756	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
320389004757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389004758	putative substrate translocation pore; other site
320389004759	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
320389004760	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389004761	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
320389004762	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389004763	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
320389004764	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
320389004765	E3 interaction surface; other site
320389004766	lipoyl attachment site [posttranslational modification]; other site
320389004767	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
320389004768	e3 binding domain; Region: E3_binding; pfam02817
320389004769	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
320389004770	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
320389004771	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
320389004772	alpha subunit interface [polypeptide binding]; other site
320389004773	TPP binding site [chemical binding]; other site
320389004774	heterodimer interface [polypeptide binding]; other site
320389004775	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
320389004776	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
320389004777	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
320389004778	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
320389004779	tetramer interface [polypeptide binding]; other site
320389004780	TPP-binding site [chemical binding]; other site
320389004781	heterodimer interface [polypeptide binding]; other site
320389004782	phosphorylation loop region [posttranslational modification]
320389004783	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
320389004784	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
320389004785	hydrophobic ligand binding site; other site
320389004786	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389004787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389004788	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
320389004789	substrate binding pocket [chemical binding]; other site
320389004790	dimerization interface [polypeptide binding]; other site
320389004791	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
320389004792	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
320389004793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
320389004794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389004795	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
320389004796	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
320389004797	nucleophile elbow; other site
320389004798	Patatin phospholipase; Region: DUF3734; pfam12536
320389004799	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
320389004800	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
320389004801	ribonucleotide reductase-like protein; Provisional; Region: PRK06948
320389004802	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
320389004803	active site
320389004804	dimer interface [polypeptide binding]; other site
320389004805	effector binding site; other site
320389004806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
320389004807	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
320389004808	AAA domain; Region: AAA_33; pfam13671
320389004809	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
320389004810	FMN binding site [chemical binding]; other site
320389004811	dimer interface [polypeptide binding]; other site
320389004812	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
320389004813	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
320389004814	Sulfate transporter family; Region: Sulfate_transp; pfam00916
320389004815	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
320389004816	FOG: CBS domain [General function prediction only]; Region: COG0517
320389004817	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
320389004818	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
320389004819	putative FMN binding site [chemical binding]; other site
320389004820	NADPH bind site [chemical binding]; other site
320389004821	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
320389004822	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
320389004823	putative dimer interface [polypeptide binding]; other site
320389004824	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389004825	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389004826	trimer interface [polypeptide binding]; other site
320389004827	eyelet of channel; other site
320389004828	putative acyl-CoA synthetase; Provisional; Region: PRK06018
320389004829	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389004830	acyl-activating enzyme (AAE) consensus motif; other site
320389004831	AMP binding site [chemical binding]; other site
320389004832	active site
320389004833	CoA binding site [chemical binding]; other site
320389004834	AAA ATPase domain; Region: AAA_16; pfam13191
320389004835	AAA domain; Region: AAA_22; pfam13401
320389004836	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389004837	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389004838	DNA binding residues [nucleotide binding]
320389004839	dimerization interface [polypeptide binding]; other site
320389004840	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
320389004841	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
320389004842	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
320389004843	NADP binding site [chemical binding]; other site
320389004844	dimer interface [polypeptide binding]; other site
320389004845	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
320389004846	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
320389004847	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
320389004848	benzoate transport; Region: 2A0115; TIGR00895
320389004849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389004850	putative substrate translocation pore; other site
320389004851	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
320389004852	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389004853	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
320389004854	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
320389004855	molybdopterin cofactor binding site; other site
320389004856	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
320389004857	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
320389004858	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
320389004859	putative molybdopterin cofactor binding site; other site
320389004860	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
320389004861	4Fe-4S binding domain; Region: Fer4; pfam00037
320389004862	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
320389004863	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
320389004864	putative active site [active]
320389004865	putative metal binding site [ion binding]; other site
320389004866	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
320389004867	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
320389004868	Transglycosylase; Region: Transgly; pfam00912
320389004869	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
320389004870	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
320389004871	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
320389004872	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389004873	catalytic residues [active]
320389004874	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389004875	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389004876	trimer interface [polypeptide binding]; other site
320389004877	eyelet of channel; other site
320389004878	amidase; Provisional; Region: PRK08137
320389004879	Amidase; Region: Amidase; cl11426
320389004880	putative acetyltransferase YhhY; Provisional; Region: PRK10140
320389004881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389004882	Coenzyme A binding pocket [chemical binding]; other site
320389004883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389004884	putative acetyltransferase YhhY; Provisional; Region: PRK10140
320389004885	Coenzyme A binding pocket [chemical binding]; other site
320389004886	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
320389004887	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
320389004888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389004889	D-loop; other site
320389004890	H-loop/switch region; other site
320389004891	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389004892	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
320389004893	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
320389004894	Histidine kinase; Region: HisKA_3; pfam07730
320389004895	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
320389004896	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389004897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389004898	active site
320389004899	phosphorylation site [posttranslational modification]
320389004900	intermolecular recognition site; other site
320389004901	dimerization interface [polypeptide binding]; other site
320389004902	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389004903	DNA binding residues [nucleotide binding]
320389004904	dimerization interface [polypeptide binding]; other site
320389004905	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389004906	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389004907	Transposase domain (DUF772); Region: DUF772; pfam05598
320389004908	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389004909	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389004910	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
320389004911	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
320389004912	PAS domain; Region: PAS_9; pfam13426
320389004913	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389004914	putative active site [active]
320389004915	heme pocket [chemical binding]; other site
320389004916	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389004917	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389004918	metal binding site [ion binding]; metal-binding site
320389004919	active site
320389004920	I-site; other site
320389004921	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
320389004922	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
320389004923	Lipase (class 2); Region: Lipase_2; pfam01674
320389004924	PGAP1-like protein; Region: PGAP1; pfam07819
320389004925	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
320389004926	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
320389004927	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
320389004928	FtsX-like permease family; Region: FtsX; pfam02687
320389004929	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
320389004930	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
320389004931	Walker A/P-loop; other site
320389004932	ATP binding site [chemical binding]; other site
320389004933	Q-loop/lid; other site
320389004934	ABC transporter signature motif; other site
320389004935	Walker B; other site
320389004936	D-loop; other site
320389004937	H-loop/switch region; other site
320389004938	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389004939	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
320389004940	Cytochrome P450; Region: p450; cl12078
320389004941	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
320389004942	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
320389004943	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
320389004944	putative NADP binding site [chemical binding]; other site
320389004945	active site
320389004946	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
320389004947	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
320389004948	putative NAD(P) binding site [chemical binding]; other site
320389004949	active site
320389004950	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
320389004951	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
320389004952	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
320389004953	active site
320389004954	active site
320389004955	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
320389004956	active site
320389004957	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
320389004958	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
320389004959	putative NADP binding site [chemical binding]; other site
320389004960	active site
320389004961	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
320389004962	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
320389004963	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
320389004964	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
320389004965	VacJ like lipoprotein; Region: VacJ; cl01073
320389004966	hypothetical protein; Provisional; Region: PRK07483
320389004967	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389004968	inhibitor-cofactor binding pocket; inhibition site
320389004969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389004970	catalytic residue [active]
320389004971	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
320389004972	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
320389004973	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389004974	Walker A/P-loop; other site
320389004975	ATP binding site [chemical binding]; other site
320389004976	Q-loop/lid; other site
320389004977	ABC transporter signature motif; other site
320389004978	Walker B; other site
320389004979	D-loop; other site
320389004980	H-loop/switch region; other site
320389004981	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389004982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389004983	dimer interface [polypeptide binding]; other site
320389004984	conserved gate region; other site
320389004985	putative PBP binding loops; other site
320389004986	ABC-ATPase subunit interface; other site
320389004987	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389004988	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389004989	substrate binding pocket [chemical binding]; other site
320389004990	membrane-bound complex binding site; other site
320389004991	hinge residues; other site
320389004992	hypothetical protein; Provisional; Region: PRK07077
320389004993	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
320389004994	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
320389004995	Active site cavity [active]
320389004996	catalytic acid [active]
320389004997	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
320389004998	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389004999	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389005000	PAS fold; Region: PAS_4; pfam08448
320389005001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389005002	putative active site [active]
320389005003	heme pocket [chemical binding]; other site
320389005004	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389005005	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389005006	metal binding site [ion binding]; metal-binding site
320389005007	active site
320389005008	I-site; other site
320389005009	Response regulator receiver domain; Region: Response_reg; pfam00072
320389005010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389005011	active site
320389005012	phosphorylation site [posttranslational modification]
320389005013	intermolecular recognition site; other site
320389005014	dimerization interface [polypeptide binding]; other site
320389005015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389005016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389005017	dimer interface [polypeptide binding]; other site
320389005018	phosphorylation site [posttranslational modification]
320389005019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389005020	ATP binding site [chemical binding]; other site
320389005021	Mg2+ binding site [ion binding]; other site
320389005022	G-X-G motif; other site
320389005023	Response regulator receiver domain; Region: Response_reg; pfam00072
320389005024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389005025	active site
320389005026	phosphorylation site [posttranslational modification]
320389005027	intermolecular recognition site; other site
320389005028	dimerization interface [polypeptide binding]; other site
320389005029	Predicted flavoprotein [General function prediction only]; Region: COG0431
320389005030	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
320389005031	Putative zinc-finger; Region: zf-HC2; pfam13490
320389005032	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
320389005033	ArsC family; Region: ArsC; pfam03960
320389005034	catalytic residues [active]
320389005035	ParA-like protein; Provisional; Region: PHA02518
320389005036	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
320389005037	P-loop; other site
320389005038	Magnesium ion binding site [ion binding]; other site
320389005039	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
320389005040	ParB-like nuclease domain; Region: ParB; smart00470
320389005041	Transposase domain (DUF772); Region: DUF772; pfam05598
320389005042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389005043	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389005044	Initiator Replication protein; Region: Rep_3; pfam01051
320389005045	DnaA N-terminal domain; Region: DnaA_N; pfam11638
320389005046	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
320389005047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389005048	Walker A motif; other site
320389005049	ATP binding site [chemical binding]; other site
320389005050	Walker B motif; other site
320389005051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
320389005052	arginine finger; other site
320389005053	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
320389005054	DnaA box-binding interface [nucleotide binding]; other site
320389005055	DNA polymerase III subunit beta; Validated; Region: PRK05643
320389005056	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
320389005057	putative DNA binding surface [nucleotide binding]; other site
320389005058	dimer interface [polypeptide binding]; other site
320389005059	beta-clamp/clamp loader binding surface; other site
320389005060	beta-clamp/translesion DNA polymerase binding surface; other site
320389005061	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
320389005062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389005063	ATP binding site [chemical binding]; other site
320389005064	Mg2+ binding site [ion binding]; other site
320389005065	G-X-G motif; other site
320389005066	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
320389005067	anchoring element; other site
320389005068	dimer interface [polypeptide binding]; other site
320389005069	ATP binding site [chemical binding]; other site
320389005070	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
320389005071	active site
320389005072	putative metal-binding site [ion binding]; other site
320389005073	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
320389005074	Transposase; Region: HTH_Tnp_1; pfam01527
320389005075	HTH-like domain; Region: HTH_21; pfam13276
320389005076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005077	Integrase core domain; Region: rve; pfam00665
320389005078	Integrase core domain; Region: rve_3; pfam13683
320389005079	Gram-negative bacterial tonB protein; Region: TonB; cl10048
320389005080	hypothetical protein; Provisional; Region: PRK11667
320389005081	O-Antigen ligase; Region: Wzy_C; pfam04932
320389005082	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
320389005083	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
320389005084	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
320389005085	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
320389005086	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
320389005087	CoA binding domain; Region: CoA_binding; smart00881
320389005088	CoA-ligase; Region: Ligase_CoA; pfam00549
320389005089	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
320389005090	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
320389005091	CoA-ligase; Region: Ligase_CoA; pfam00549
320389005092	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
320389005093	recombination regulator RecX; Provisional; Region: recX; PRK14136
320389005094	recombinase A; Provisional; Region: recA; PRK09354
320389005095	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
320389005096	hexamer interface [polypeptide binding]; other site
320389005097	Walker A motif; other site
320389005098	ATP binding site [chemical binding]; other site
320389005099	Walker B motif; other site
320389005100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389005101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389005102	active site
320389005103	phosphorylation site [posttranslational modification]
320389005104	intermolecular recognition site; other site
320389005105	dimerization interface [polypeptide binding]; other site
320389005106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389005107	DNA binding site [nucleotide binding]
320389005108	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
320389005109	HAMP domain; Region: HAMP; pfam00672
320389005110	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389005111	dimer interface [polypeptide binding]; other site
320389005112	phosphorylation site [posttranslational modification]
320389005113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389005114	ATP binding site [chemical binding]; other site
320389005115	Mg2+ binding site [ion binding]; other site
320389005116	G-X-G motif; other site
320389005117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389005118	putative substrate translocation pore; other site
320389005119	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
320389005120	HTH-like domain; Region: HTH_21; pfam13276
320389005121	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005122	Integrase core domain; Region: rve; pfam00665
320389005123	Integrase core domain; Region: rve_3; pfam13683
320389005124	Transposase; Region: HTH_Tnp_1; pfam01527
320389005125	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
320389005126	trimer interface [polypeptide binding]; other site
320389005127	dimer interface [polypeptide binding]; other site
320389005128	putative active site [active]
320389005129	Peptidase family M48; Region: Peptidase_M48; pfam01435
320389005130	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
320389005131	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
320389005132	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
320389005133	SnoaL-like domain; Region: SnoaL_3; pfam13474
320389005134	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389005135	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389005136	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389005137	putative active site [active]
320389005138	Zinc-finger domain; Region: zf-CHCC; cl01821
320389005139	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
320389005140	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
320389005141	homodimer interface [polypeptide binding]; other site
320389005142	substrate-cofactor binding pocket; other site
320389005143	catalytic residue [active]
320389005144	AzlC protein; Region: AzlC; cl00570
320389005145	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
320389005146	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
320389005147	Phosphoglycerate kinase; Region: PGK; pfam00162
320389005148	substrate binding site [chemical binding]; other site
320389005149	hinge regions; other site
320389005150	ADP binding site [chemical binding]; other site
320389005151	catalytic site [active]
320389005152	pyruvate kinase; Provisional; Region: PRK05826
320389005153	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
320389005154	domain interfaces; other site
320389005155	active site
320389005156	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
320389005157	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
320389005158	intersubunit interface [polypeptide binding]; other site
320389005159	active site
320389005160	zinc binding site [ion binding]; other site
320389005161	Na+ binding site [ion binding]; other site
320389005162	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
320389005163	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
320389005164	ATP binding site [chemical binding]; other site
320389005165	active site
320389005166	substrate binding site [chemical binding]; other site
320389005167	AIR carboxylase; Region: AIRC; pfam00731
320389005168	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
320389005169	ATP-grasp domain; Region: ATP-grasp; pfam02222
320389005170	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
320389005171	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
320389005172	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
320389005173	active site
320389005174	catalytic triad [active]
320389005175	oxyanion hole [active]
320389005176	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
320389005177	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
320389005178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389005179	active site
320389005180	phosphorylation site [posttranslational modification]
320389005181	intermolecular recognition site; other site
320389005182	dimerization interface [polypeptide binding]; other site
320389005183	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389005184	DNA binding site [nucleotide binding]
320389005185	sensor protein QseC; Provisional; Region: PRK10337
320389005186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389005187	ATP binding site [chemical binding]; other site
320389005188	Mg2+ binding site [ion binding]; other site
320389005189	G-X-G motif; other site
320389005190	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
320389005191	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
320389005192	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
320389005193	protein binding site [polypeptide binding]; other site
320389005194	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
320389005195	protein binding site [polypeptide binding]; other site
320389005196	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
320389005197	Domain of unknown function (DUF427); Region: DUF427; pfam04248
320389005198	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
320389005199	hydrophobic ligand binding site; other site
320389005200	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
320389005201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389005202	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
320389005203	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
320389005204	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389005205	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389005206	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
320389005207	Protein export membrane protein; Region: SecD_SecF; cl14618
320389005208	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
320389005209	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
320389005210	Transposase; Region: HTH_Tnp_1; pfam01527
320389005211	HTH-like domain; Region: HTH_21; pfam13276
320389005212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005213	Integrase core domain; Region: rve; pfam00665
320389005214	Integrase core domain; Region: rve_3; pfam13683
320389005215	xanthine permease; Region: pbuX; TIGR03173
320389005216	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
320389005217	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
320389005218	conserved cys residue [active]
320389005219	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389005220	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389005221	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
320389005222	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
320389005223	substrate binding site [chemical binding]; other site
320389005224	catalytic Zn binding site [ion binding]; other site
320389005225	NAD binding site [chemical binding]; other site
320389005226	structural Zn binding site [ion binding]; other site
320389005227	dimer interface [polypeptide binding]; other site
320389005228	S-formylglutathione hydrolase; Region: PLN02442
320389005229	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
320389005230	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
320389005231	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
320389005232	dimer interface [polypeptide binding]; other site
320389005233	putative PBP binding regions; other site
320389005234	ABC-ATPase subunit  interface; other site
320389005235	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
320389005236	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
320389005237	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
320389005238	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
320389005239	metal binding site [ion binding]; metal-binding site
320389005240	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
320389005241	metal binding site 2 [ion binding]; metal-binding site
320389005242	putative DNA binding helix; other site
320389005243	metal binding site 1 [ion binding]; metal-binding site
320389005244	dimer interface [polypeptide binding]; other site
320389005245	structural Zn2+ binding site [ion binding]; other site
320389005246	sorbitol dehydrogenase; Provisional; Region: PRK07067
320389005247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389005248	NAD(P) binding site [chemical binding]; other site
320389005249	active site
320389005250	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
320389005251	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
320389005252	substrate binding site [chemical binding]; other site
320389005253	ATP binding site [chemical binding]; other site
320389005254	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
320389005255	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
320389005256	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
320389005257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389005258	dimer interface [polypeptide binding]; other site
320389005259	conserved gate region; other site
320389005260	putative PBP binding loops; other site
320389005261	ABC-ATPase subunit interface; other site
320389005262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
320389005263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389005264	dimer interface [polypeptide binding]; other site
320389005265	conserved gate region; other site
320389005266	putative PBP binding loops; other site
320389005267	ABC-ATPase subunit interface; other site
320389005268	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389005269	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
320389005270	active site
320389005271	motif I; other site
320389005272	motif II; other site
320389005273	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
320389005274	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
320389005275	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
320389005276	Walker A/P-loop; other site
320389005277	ATP binding site [chemical binding]; other site
320389005278	Q-loop/lid; other site
320389005279	ABC transporter signature motif; other site
320389005280	Walker B; other site
320389005281	D-loop; other site
320389005282	H-loop/switch region; other site
320389005283	TOBE domain; Region: TOBE; pfam03459
320389005284	TOBE domain; Region: TOBE_2; pfam08402
320389005285	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
320389005286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389005287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389005288	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
320389005289	putative effector binding pocket; other site
320389005290	putative dimerization interface [polypeptide binding]; other site
320389005291	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
320389005292	Beta-lactamase; Region: Beta-lactamase; pfam00144
320389005293	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
320389005294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389005295	putative substrate translocation pore; other site
320389005296	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
320389005297	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
320389005298	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
320389005299	N- and C-terminal domain interface [polypeptide binding]; other site
320389005300	D-xylulose kinase; Region: XylB; TIGR01312
320389005301	active site
320389005302	MgATP binding site [chemical binding]; other site
320389005303	catalytic site [active]
320389005304	metal binding site [ion binding]; metal-binding site
320389005305	xylulose binding site [chemical binding]; other site
320389005306	homodimer interface [polypeptide binding]; other site
320389005307	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
320389005308	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
320389005309	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
320389005310	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389005311	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389005312	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389005313	dimerization interface [polypeptide binding]; other site
320389005314	benzoylformate decarboxylase; Reviewed; Region: PRK07092
320389005315	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
320389005316	PYR/PP interface [polypeptide binding]; other site
320389005317	dimer interface [polypeptide binding]; other site
320389005318	TPP binding site [chemical binding]; other site
320389005319	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389005320	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
320389005321	TPP-binding site [chemical binding]; other site
320389005322	dimer interface [polypeptide binding]; other site
320389005323	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
320389005324	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
320389005325	NAD(P) binding site [chemical binding]; other site
320389005326	catalytic residues [active]
320389005327	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
320389005328	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
320389005329	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
320389005330	benzoate transport; Region: 2A0115; TIGR00895
320389005331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389005332	putative substrate translocation pore; other site
320389005333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389005334	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
320389005335	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
320389005336	kynureninase; Region: kynureninase; TIGR01814
320389005337	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389005338	catalytic residue [active]
320389005339	Putative cyclase; Region: Cyclase; cl00814
320389005340	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389005341	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389005342	putative DNA binding site [nucleotide binding]; other site
320389005343	putative Zn2+ binding site [ion binding]; other site
320389005344	AsnC family; Region: AsnC_trans_reg; pfam01037
320389005345	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
320389005346	methionine sulfoxide reductase A; Provisional; Region: PRK14054
320389005347	Protein of unknown function DUF72; Region: DUF72; pfam01904
320389005348	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
320389005349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389005350	S-adenosylmethionine binding site [chemical binding]; other site
320389005351	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
320389005352	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
320389005353	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
320389005354	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
320389005355	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
320389005356	putative ATP binding site [chemical binding]; other site
320389005357	putative substrate interface [chemical binding]; other site
320389005358	Pirin-related protein [General function prediction only]; Region: COG1741
320389005359	Pirin; Region: Pirin; pfam02678
320389005360	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
320389005361	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
320389005362	EamA-like transporter family; Region: EamA; pfam00892
320389005363	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
320389005364	epoxyqueuosine reductase; Region: TIGR00276
320389005365	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
320389005366	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
320389005367	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
320389005368	DNA binding site [nucleotide binding]
320389005369	active site
320389005370	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
320389005371	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
320389005372	active site
320389005373	Int/Topo IB signature motif; other site
320389005374	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
320389005375	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389005376	acyl-activating enzyme (AAE) consensus motif; other site
320389005377	AMP binding site [chemical binding]; other site
320389005378	active site
320389005379	CoA binding site [chemical binding]; other site
320389005380	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
320389005381	putative deacylase active site [active]
320389005382	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
320389005383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
320389005384	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
320389005385	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
320389005386	FAD binding domain; Region: FAD_binding_4; pfam01565
320389005387	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
320389005388	ornithine carbamoyltransferase; Provisional; Region: PRK00779
320389005389	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
320389005390	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
320389005391	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
320389005392	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
320389005393	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
320389005394	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
320389005395	Uncharacterized conserved protein [Function unknown]; Region: COG2912
320389005396	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
320389005397	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
320389005398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389005399	NAD(P) binding site [chemical binding]; other site
320389005400	active site
320389005401	Transposase domain (DUF772); Region: DUF772; pfam05598
320389005402	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389005403	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389005404	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
320389005405	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
320389005406	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
320389005407	isocitrate dehydrogenase; Validated; Region: PRK07362
320389005408	isocitrate dehydrogenase; Reviewed; Region: PRK07006
320389005409	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
320389005410	pseudouridine synthase; Region: TIGR00093
320389005411	active site
320389005412	HTH-like domain; Region: HTH_21; pfam13276
320389005413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005414	Integrase core domain; Region: rve; pfam00665
320389005415	Integrase core domain; Region: rve_3; pfam13683
320389005416	Transposase; Region: HTH_Tnp_1; pfam01527
320389005417	HTH-like domain; Region: HTH_21; pfam13276
320389005418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005419	Integrase core domain; Region: rve; pfam00665
320389005420	Integrase core domain; Region: rve_3; pfam13683
320389005421	Transposase; Region: HTH_Tnp_1; pfam01527
320389005422	Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549
320389005423	chorismate mutase; Provisional; Region: PRK09269
320389005424	Chorismate mutase type II; Region: CM_2; cl00693
320389005425	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
320389005426	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
320389005427	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389005428	N-terminal plug; other site
320389005429	ligand-binding site [chemical binding]; other site
320389005430	BNR repeat-like domain; Region: BNR_2; pfam13088
320389005431	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
320389005432	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389005433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389005434	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389005435	fructose-1,6-bisphosphatase family protein; Region: PLN02628
320389005436	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
320389005437	AMP binding site [chemical binding]; other site
320389005438	metal binding site [ion binding]; metal-binding site
320389005439	active site
320389005440	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
320389005441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389005442	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
320389005443	putative dimerization interface [polypeptide binding]; other site
320389005444	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
320389005445	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
320389005446	THF binding site; other site
320389005447	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
320389005448	substrate binding site [chemical binding]; other site
320389005449	THF binding site; other site
320389005450	zinc-binding site [ion binding]; other site
320389005451	aminopeptidase N; Provisional; Region: pepN; PRK14015
320389005452	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
320389005453	active site
320389005454	Zn binding site [ion binding]; other site
320389005455	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
320389005456	Predicted membrane protein [Function unknown]; Region: COG2119
320389005457	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
320389005458	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
320389005459	guanine deaminase; Provisional; Region: PRK09228
320389005460	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389005461	active site
320389005462	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
320389005463	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
320389005464	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
320389005465	active site
320389005466	purine riboside binding site [chemical binding]; other site
320389005467	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
320389005468	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
320389005469	XdhC Rossmann domain; Region: XdhC_C; pfam13478
320389005470	disulfide bond formation protein B; Provisional; Region: PRK02110
320389005471	amidase; Provisional; Region: PRK07056
320389005472	Amidase; Region: Amidase; cl11426
320389005473	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
320389005474	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
320389005475	catalytic triad [active]
320389005476	citrate-proton symporter; Provisional; Region: PRK15075
320389005477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389005478	putative substrate translocation pore; other site
320389005479	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389005480	binding surface
320389005481	TPR motif; other site
320389005482	TPR repeat; Region: TPR_11; pfam13414
320389005483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389005484	binding surface
320389005485	TPR motif; other site
320389005486	TPR repeat; Region: TPR_11; pfam13414
320389005487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389005488	TPR repeat; Region: TPR_11; pfam13414
320389005489	TPR motif; other site
320389005490	binding surface
320389005491	TPR repeat; Region: TPR_11; pfam13414
320389005492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389005493	binding surface
320389005494	TPR motif; other site
320389005495	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389005496	hypothetical protein; Provisional; Region: PRK06184
320389005497	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
320389005498	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
320389005499	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389005500	catalytic loop [active]
320389005501	iron binding site [ion binding]; other site
320389005502	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
320389005503	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
320389005504	[4Fe-4S] binding site [ion binding]; other site
320389005505	molybdopterin cofactor binding site; other site
320389005506	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
320389005507	molybdopterin cofactor binding site; other site
320389005508	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
320389005509	putative dimer interface [polypeptide binding]; other site
320389005510	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
320389005511	SLBB domain; Region: SLBB; pfam10531
320389005512	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
320389005513	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
320389005514	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
320389005515	putative dimer interface [polypeptide binding]; other site
320389005516	[2Fe-2S] cluster binding site [ion binding]; other site
320389005517	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
320389005518	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
320389005519	PBP superfamily domain; Region: PBP_like; pfam12727
320389005520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389005521	S-adenosylmethionine binding site [chemical binding]; other site
320389005522	HTH-like domain; Region: HTH_21; pfam13276
320389005523	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005524	Integrase core domain; Region: rve; pfam00665
320389005525	Integrase core domain; Region: rve_3; pfam13683
320389005526	Transposase; Region: HTH_Tnp_1; pfam01527
320389005527	phosphoglycolate phosphatase; Provisional; Region: PRK13226
320389005528	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389005529	motif II; other site
320389005530	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
320389005531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389005532	S-adenosylmethionine binding site [chemical binding]; other site
320389005533	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389005534	ligand binding site [chemical binding]; other site
320389005535	DNA gyrase subunit A; Validated; Region: PRK05560
320389005536	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
320389005537	CAP-like domain; other site
320389005538	active site
320389005539	primary dimer interface [polypeptide binding]; other site
320389005540	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
320389005541	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
320389005542	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
320389005543	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
320389005544	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
320389005545	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
320389005546	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
320389005547	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
320389005548	homodimer interface [polypeptide binding]; other site
320389005549	substrate-cofactor binding pocket; other site
320389005550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389005551	catalytic residue [active]
320389005552	Chorismate mutase type II; Region: CM_2; smart00830
320389005553	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
320389005554	Prephenate dehydratase; Region: PDT; pfam00800
320389005555	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
320389005556	putative L-Phe binding site [chemical binding]; other site
320389005557	bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861
320389005558	prephenate dehydrogenase; Validated; Region: PRK08507
320389005559	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
320389005560	hinge; other site
320389005561	active site
320389005562	cytidylate kinase; Provisional; Region: cmk; PRK00023
320389005563	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
320389005564	CMP-binding site; other site
320389005565	The sites determining sugar specificity; other site
320389005566	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
320389005567	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
320389005568	RNA binding site [nucleotide binding]; other site
320389005569	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
320389005570	RNA binding site [nucleotide binding]; other site
320389005571	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
320389005572	RNA binding site [nucleotide binding]; other site
320389005573	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
320389005574	RNA binding site [nucleotide binding]; other site
320389005575	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
320389005576	RNA binding site [nucleotide binding]; other site
320389005577	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
320389005578	RNA binding site [nucleotide binding]; other site
320389005579	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
320389005580	IHF dimer interface [polypeptide binding]; other site
320389005581	IHF - DNA interface [nucleotide binding]; other site
320389005582	Transposase domain (DUF772); Region: DUF772; pfam05598
320389005583	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389005584	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389005585	tetratricopeptide repeat protein; Provisional; Region: PRK11788
320389005586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389005587	binding surface
320389005588	TPR motif; other site
320389005589	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
320389005590	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
320389005591	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
320389005592	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
320389005593	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
320389005594	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
320389005595	putative ribose interaction site [chemical binding]; other site
320389005596	putative ADP binding site [chemical binding]; other site
320389005597	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
320389005598	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
320389005599	NADP binding site [chemical binding]; other site
320389005600	homopentamer interface [polypeptide binding]; other site
320389005601	substrate binding site [chemical binding]; other site
320389005602	active site
320389005603	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
320389005604	cysteine synthase B; Region: cysM; TIGR01138
320389005605	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
320389005606	dimer interface [polypeptide binding]; other site
320389005607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389005608	catalytic residue [active]
320389005609	Transglycosylase SLT domain; Region: SLT_2; pfam13406
320389005610	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
320389005611	N-acetyl-D-glucosamine binding site [chemical binding]; other site
320389005612	catalytic residue [active]
320389005613	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
320389005614	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
320389005615	putative active site [active]
320389005616	Zn binding site [ion binding]; other site
320389005617	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
320389005618	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
320389005619	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
320389005620	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
320389005621	Walker A/P-loop; other site
320389005622	ATP binding site [chemical binding]; other site
320389005623	Q-loop/lid; other site
320389005624	ABC transporter signature motif; other site
320389005625	Walker B; other site
320389005626	D-loop; other site
320389005627	H-loop/switch region; other site
320389005628	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
320389005629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389005630	dimer interface [polypeptide binding]; other site
320389005631	conserved gate region; other site
320389005632	ABC-ATPase subunit interface; other site
320389005633	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
320389005634	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
320389005635	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
320389005636	Ligand binding site [chemical binding]; other site
320389005637	Electron transfer flavoprotein domain; Region: ETF; pfam01012
320389005638	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
320389005639	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
320389005640	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
320389005641	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
320389005642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389005643	hydroxyglutarate oxidase; Provisional; Region: PRK11728
320389005644	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
320389005645	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
320389005646	AsnC family; Region: AsnC_trans_reg; pfam01037
320389005647	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
320389005648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389005649	FeS/SAM binding site; other site
320389005650	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
320389005651	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
320389005652	RimM N-terminal domain; Region: RimM; pfam01782
320389005653	PRC-barrel domain; Region: PRC; pfam05239
320389005654	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
320389005655	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
320389005656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389005657	Coenzyme A binding pocket [chemical binding]; other site
320389005658	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
320389005659	putative active site [active]
320389005660	putative CoA binding site [chemical binding]; other site
320389005661	nudix motif; other site
320389005662	metal binding site [ion binding]; metal-binding site
320389005663	CobD/CbiB family protein; Provisional; Region: PRK07630
320389005664	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
320389005665	GTPase RsgA; Reviewed; Region: PRK00098
320389005666	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
320389005667	RNA binding site [nucleotide binding]; other site
320389005668	homodimer interface [polypeptide binding]; other site
320389005669	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
320389005670	GTPase/Zn-binding domain interface [polypeptide binding]; other site
320389005671	GTP/Mg2+ binding site [chemical binding]; other site
320389005672	G4 box; other site
320389005673	G5 box; other site
320389005674	G1 box; other site
320389005675	Switch I region; other site
320389005676	G2 box; other site
320389005677	G3 box; other site
320389005678	Switch II region; other site
320389005679	Peptidase family M48; Region: Peptidase_M48; pfam01435
320389005680	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
320389005681	catalytic site [active]
320389005682	putative active site [active]
320389005683	putative substrate binding site [chemical binding]; other site
320389005684	dimer interface [polypeptide binding]; other site
320389005685	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
320389005686	MPT binding site; other site
320389005687	trimer interface [polypeptide binding]; other site
320389005688	hypothetical protein; Provisional; Region: PRK05255
320389005689	peptidase PmbA; Provisional; Region: PRK11040
320389005690	Transposase domain (DUF772); Region: DUF772; pfam05598
320389005691	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389005692	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389005693	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
320389005694	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
320389005695	folate binding site [chemical binding]; other site
320389005696	NADP+ binding site [chemical binding]; other site
320389005697	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389005698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389005699	Walker A motif; other site
320389005700	ATP binding site [chemical binding]; other site
320389005701	Walker B motif; other site
320389005702	arginine finger; other site
320389005703	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
320389005704	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389005705	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389005706	Walker A motif; other site
320389005707	ATP binding site [chemical binding]; other site
320389005708	Walker B motif; other site
320389005709	arginine finger; other site
320389005710	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389005711	thymidylate synthase; Provisional; Region: thyA; PRK13821
320389005712	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
320389005713	dimerization interface [polypeptide binding]; other site
320389005714	active site
320389005715	Transposase domain (DUF772); Region: DUF772; pfam05598
320389005716	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389005717	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389005718	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389005719	dimerization interface [polypeptide binding]; other site
320389005720	putative DNA binding site [nucleotide binding]; other site
320389005721	putative Zn2+ binding site [ion binding]; other site
320389005722	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
320389005723	fumarate hydratase; Reviewed; Region: fumC; PRK00485
320389005724	Class II fumarases; Region: Fumarase_classII; cd01362
320389005725	active site
320389005726	tetramer interface [polypeptide binding]; other site
320389005727	HTH-like domain; Region: HTH_21; pfam13276
320389005728	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005729	Integrase core domain; Region: rve; pfam00665
320389005730	Integrase core domain; Region: rve_3; pfam13683
320389005731	Transposase; Region: HTH_Tnp_1; pfam01527
320389005732	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
320389005733	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
320389005734	TM-ABC transporter signature motif; other site
320389005735	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
320389005736	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
320389005737	Walker A/P-loop; other site
320389005738	ATP binding site [chemical binding]; other site
320389005739	Q-loop/lid; other site
320389005740	ABC transporter signature motif; other site
320389005741	Walker B; other site
320389005742	D-loop; other site
320389005743	H-loop/switch region; other site
320389005744	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
320389005745	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
320389005746	Walker A/P-loop; other site
320389005747	ATP binding site [chemical binding]; other site
320389005748	Q-loop/lid; other site
320389005749	ABC transporter signature motif; other site
320389005750	Walker B; other site
320389005751	D-loop; other site
320389005752	H-loop/switch region; other site
320389005753	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
320389005754	putative acetyltransferase; Provisional; Region: PRK03624
320389005755	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
320389005756	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
320389005757	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389005758	inhibitor-cofactor binding pocket; inhibition site
320389005759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389005760	catalytic residue [active]
320389005761	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
320389005762	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389005763	catalytic loop [active]
320389005764	iron binding site [ion binding]; other site
320389005765	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
320389005766	FAD binding pocket [chemical binding]; other site
320389005767	FAD binding motif [chemical binding]; other site
320389005768	phosphate binding motif [ion binding]; other site
320389005769	beta-alpha-beta structure motif; other site
320389005770	NAD binding pocket [chemical binding]; other site
320389005771	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389005772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389005773	NAD(P) binding site [chemical binding]; other site
320389005774	active site
320389005775	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389005776	RNA binding surface [nucleotide binding]; other site
320389005777	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
320389005778	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
320389005779	active site
320389005780	uracil binding [chemical binding]; other site
320389005781	CopC domain; Region: CopC; pfam04234
320389005782	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389005783	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389005784	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389005785	dimerization interface [polypeptide binding]; other site
320389005786	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389005787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389005788	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389005789	dimerization interface [polypeptide binding]; other site
320389005790	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389005791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
320389005792	MOSC domain; Region: MOSC; pfam03473
320389005793	3-alpha domain; Region: 3-alpha; pfam03475
320389005794	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
320389005795	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
320389005796	inhibitor site; inhibition site
320389005797	active site
320389005798	dimer interface [polypeptide binding]; other site
320389005799	catalytic residue [active]
320389005800	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
320389005801	intersubunit interface [polypeptide binding]; other site
320389005802	active site
320389005803	Zn2+ binding site [ion binding]; other site
320389005804	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
320389005805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389005806	non-specific DNA binding site [nucleotide binding]; other site
320389005807	salt bridge; other site
320389005808	sequence-specific DNA binding site [nucleotide binding]; other site
320389005809	Cupin domain; Region: Cupin_2; pfam07883
320389005810	HTH-like domain; Region: HTH_21; pfam13276
320389005811	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389005812	Integrase core domain; Region: rve; pfam00665
320389005813	Integrase core domain; Region: rve_3; pfam13683
320389005814	Transposase; Region: HTH_Tnp_1; pfam01527
320389005815	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
320389005816	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389005817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389005818	homodimer interface [polypeptide binding]; other site
320389005819	catalytic residue [active]
320389005820	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
320389005821	EamA-like transporter family; Region: EamA; pfam00892
320389005822	EamA-like transporter family; Region: EamA; pfam00892
320389005823	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
320389005824	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389005825	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389005826	DNA-binding site [nucleotide binding]; DNA binding site
320389005827	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389005828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389005829	homodimer interface [polypeptide binding]; other site
320389005830	catalytic residue [active]
320389005831	heat shock protein 90; Provisional; Region: PRK05218
320389005832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389005833	ATP binding site [chemical binding]; other site
320389005834	Mg2+ binding site [ion binding]; other site
320389005835	G-X-G motif; other site
320389005836	Chorismate lyase; Region: Chor_lyase; cl01230
320389005837	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
320389005838	putative active site [active]
320389005839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
320389005840	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
320389005841	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
320389005842	Na binding site [ion binding]; other site
320389005843	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
320389005844	dimer interface [polypeptide binding]; other site
320389005845	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389005846	transaldolase-like protein; Provisional; Region: PTZ00411
320389005847	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
320389005848	active site
320389005849	dimer interface [polypeptide binding]; other site
320389005850	catalytic residue [active]
320389005851	Benzoate membrane transport protein; Region: BenE; pfam03594
320389005852	benzoate transporter; Region: benE; TIGR00843
320389005853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
320389005854	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
320389005855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389005856	Walker A motif; other site
320389005857	ATP binding site [chemical binding]; other site
320389005858	Walker B motif; other site
320389005859	arginine finger; other site
320389005860	Cytochrome c553 [Energy production and conversion]; Region: COG2863
320389005861	Cytochrome c; Region: Cytochrom_C; cl11414
320389005862	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389005863	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389005864	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
320389005865	EamA-like transporter family; Region: EamA; pfam00892
320389005866	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
320389005867	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
320389005868	minor groove reading motif; other site
320389005869	helix-hairpin-helix signature motif; other site
320389005870	substrate binding pocket [chemical binding]; other site
320389005871	active site
320389005872	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
320389005873	ferredoxin; Provisional; Region: PRK06991
320389005874	Putative Fe-S cluster; Region: FeS; pfam04060
320389005875	4Fe-4S binding domain; Region: Fer4; pfam00037
320389005876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389005877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389005878	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
320389005879	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
320389005880	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
320389005881	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
320389005882	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
320389005883	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
320389005884	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
320389005885	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
320389005886	META domain; Region: META; pfam03724
320389005887	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
320389005888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389005889	ATP-grasp domain; Region: ATP-grasp; pfam02222
320389005890	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
320389005891	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
320389005892	DEAD-like helicases superfamily; Region: DEXDc; smart00487
320389005893	ATP binding site [chemical binding]; other site
320389005894	Mg++ binding site [ion binding]; other site
320389005895	motif III; other site
320389005896	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389005897	nucleotide binding region [chemical binding]; other site
320389005898	ATP-binding site [chemical binding]; other site
320389005899	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
320389005900	active site
320389005901	HIGH motif; other site
320389005902	nucleotide binding site [chemical binding]; other site
320389005903	KMSKS motif; other site
320389005904	rhodanese superfamily protein; Provisional; Region: PRK05320
320389005905	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
320389005906	active site residue [active]
320389005907	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
320389005908	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
320389005909	putative active site [active]
320389005910	putative PHP Thumb interface [polypeptide binding]; other site
320389005911	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
320389005912	generic binding surface II; other site
320389005913	generic binding surface I; other site
320389005914	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
320389005915	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
320389005916	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
320389005917	Walker A/P-loop; other site
320389005918	ATP binding site [chemical binding]; other site
320389005919	Q-loop/lid; other site
320389005920	ABC transporter signature motif; other site
320389005921	Walker B; other site
320389005922	D-loop; other site
320389005923	H-loop/switch region; other site
320389005924	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
320389005925	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
320389005926	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389005927	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389005928	putative active site [active]
320389005929	O-Antigen ligase; Region: Wzy_C; cl04850
320389005930	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389005931	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
320389005932	putative ADP-binding pocket [chemical binding]; other site
320389005933	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389005934	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389005935	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389005936	putative active site [active]
320389005937	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
320389005938	putative metal binding site; other site
320389005939	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389005940	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
320389005941	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389005942	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389005943	DNA binding residues [nucleotide binding]
320389005944	phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398
320389005945	Pectinacetylesterase; Region: PAE; pfam03283
320389005946	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
320389005947	ribonuclease G; Provisional; Region: PRK11712
320389005948	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
320389005949	homodimer interface [polypeptide binding]; other site
320389005950	oligonucleotide binding site [chemical binding]; other site
320389005951	Maf-like protein; Region: Maf; pfam02545
320389005952	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
320389005953	active site
320389005954	dimer interface [polypeptide binding]; other site
320389005955	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
320389005956	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
320389005957	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
320389005958	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
320389005959	active site
320389005960	(T/H)XGH motif; other site
320389005961	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
320389005962	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
320389005963	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
320389005964	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
320389005965	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
320389005966	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
320389005967	hypothetical protein; Validated; Region: PRK00110
320389005968	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389005969	active site
320389005970	short chain dehydrogenase; Provisional; Region: PRK08339
320389005971	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
320389005972	putative NAD(P) binding site [chemical binding]; other site
320389005973	putative active site [active]
320389005974	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
320389005975	active site
320389005976	dimer interfaces [polypeptide binding]; other site
320389005977	catalytic residues [active]
320389005978	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
320389005979	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
320389005980	NADP binding site [chemical binding]; other site
320389005981	dimer interface [polypeptide binding]; other site
320389005982	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
320389005983	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
320389005984	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
320389005985	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
320389005986	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
320389005987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389005988	active site
320389005989	phosphorylation site [posttranslational modification]
320389005990	intermolecular recognition site; other site
320389005991	dimerization interface [polypeptide binding]; other site
320389005992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389005993	DNA binding site [nucleotide binding]
320389005994	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
320389005995	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
320389005996	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
320389005997	apolar tunnel; other site
320389005998	heme binding site [chemical binding]; other site
320389005999	dimerization interface [polypeptide binding]; other site
320389006000	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
320389006001	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
320389006002	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
320389006003	amidase; Provisional; Region: PRK07042
320389006004	Amidase; Region: Amidase; cl11426
320389006005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389006006	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389006007	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389006008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006009	putative substrate translocation pore; other site
320389006010	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
320389006011	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
320389006012	glucose-1-dehydrogenase; Provisional; Region: PRK06947
320389006013	classical (c) SDRs; Region: SDR_c; cd05233
320389006014	NAD(P) binding site [chemical binding]; other site
320389006015	active site
320389006016	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
320389006017	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389006018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389006019	Bacterial transcriptional repressor; Region: TetR; pfam13972
320389006020	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
320389006021	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389006022	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
320389006023	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389006024	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
320389006025	putative active site [active]
320389006026	putative metal binding site [ion binding]; other site
320389006027	RDD family; Region: RDD; pfam06271
320389006028	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
320389006029	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
320389006030	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389006031	RNA polymerase factor sigma-70; Validated; Region: PRK09047
320389006032	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389006033	DNA binding residues [nucleotide binding]
320389006034	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
320389006035	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
320389006036	PYR/PP interface [polypeptide binding]; other site
320389006037	dimer interface [polypeptide binding]; other site
320389006038	TPP binding site [chemical binding]; other site
320389006039	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389006040	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
320389006041	TPP-binding site [chemical binding]; other site
320389006042	dimer interface [polypeptide binding]; other site
320389006043	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
320389006044	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
320389006045	putative valine binding site [chemical binding]; other site
320389006046	dimer interface [polypeptide binding]; other site
320389006047	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
320389006048	ketol-acid reductoisomerase; Provisional; Region: PRK05479
320389006049	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
320389006050	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
320389006051	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
320389006052	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
320389006053	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
320389006054	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
320389006055	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
320389006056	Sulfate transporter family; Region: Sulfate_transp; pfam00916
320389006057	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
320389006058	active site clefts [active]
320389006059	zinc binding site [ion binding]; other site
320389006060	dimer interface [polypeptide binding]; other site
320389006061	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
320389006062	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
320389006063	putative ligand binding site [chemical binding]; other site
320389006064	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
320389006065	16S/18S rRNA binding site [nucleotide binding]; other site
320389006066	S13e-L30e interaction site [polypeptide binding]; other site
320389006067	25S rRNA binding site [nucleotide binding]; other site
320389006068	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
320389006069	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
320389006070	RNase E interface [polypeptide binding]; other site
320389006071	trimer interface [polypeptide binding]; other site
320389006072	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
320389006073	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
320389006074	RNase E interface [polypeptide binding]; other site
320389006075	trimer interface [polypeptide binding]; other site
320389006076	active site
320389006077	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
320389006078	putative nucleic acid binding region [nucleotide binding]; other site
320389006079	G-X-X-G motif; other site
320389006080	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
320389006081	RNA binding site [nucleotide binding]; other site
320389006082	domain interface; other site
320389006083	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
320389006084	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
320389006085	NAD(P) binding site [chemical binding]; other site
320389006086	triosephosphate isomerase; Provisional; Region: PRK14567
320389006087	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
320389006088	substrate binding site [chemical binding]; other site
320389006089	dimer interface [polypeptide binding]; other site
320389006090	catalytic triad [active]
320389006091	Preprotein translocase SecG subunit; Region: SecG; pfam03840
320389006092	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
320389006093	NADH dehydrogenase subunit B; Validated; Region: PRK06411
320389006094	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
320389006095	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
320389006096	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
320389006097	NADH dehydrogenase subunit D; Validated; Region: PRK06075
320389006098	NADH dehydrogenase subunit E; Validated; Region: PRK07539
320389006099	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
320389006100	putative dimer interface [polypeptide binding]; other site
320389006101	[2Fe-2S] cluster binding site [ion binding]; other site
320389006102	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
320389006103	SLBB domain; Region: SLBB; pfam10531
320389006104	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
320389006105	NADH dehydrogenase subunit G; Validated; Region: PRK09129
320389006106	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389006107	catalytic loop [active]
320389006108	iron binding site [ion binding]; other site
320389006109	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
320389006110	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
320389006111	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
320389006112	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
320389006113	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
320389006114	4Fe-4S binding domain; Region: Fer4; cl02805
320389006115	4Fe-4S binding domain; Region: Fer4; pfam00037
320389006116	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
320389006117	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
320389006118	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
320389006119	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
320389006120	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
320389006121	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
320389006122	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
320389006123	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
320389006124	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
320389006125	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
320389006126	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
320389006127	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
320389006128	dimer interface [polypeptide binding]; other site
320389006129	ADP-ribose binding site [chemical binding]; other site
320389006130	active site
320389006131	nudix motif; other site
320389006132	metal binding site [ion binding]; metal-binding site
320389006133	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
320389006134	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
320389006135	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
320389006136	FAD binding site [chemical binding]; other site
320389006137	substrate binding site [chemical binding]; other site
320389006138	catalytic base [active]
320389006139	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
320389006140	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
320389006141	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
320389006142	active site
320389006143	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
320389006144	putative active site [active]
320389006145	putative catalytic site [active]
320389006146	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
320389006147	putative active site [active]
320389006148	putative catalytic site [active]
320389006149	Right handed beta helix region; Region: Beta_helix; pfam13229
320389006150	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389006151	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
320389006152	FAD binding site [chemical binding]; other site
320389006153	substrate binding site [chemical binding]; other site
320389006154	catalytic base [active]
320389006155	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
320389006156	putative active site [active]
320389006157	putative substrate binding site [chemical binding]; other site
320389006158	ATP binding site [chemical binding]; other site
320389006159	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
320389006160	catalytic core [active]
320389006161	enoyl-CoA hydratase; Provisional; Region: PRK07511
320389006162	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389006163	substrate binding site [chemical binding]; other site
320389006164	oxyanion hole (OAH) forming residues; other site
320389006165	trimer interface [polypeptide binding]; other site
320389006166	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
320389006167	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
320389006168	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
320389006169	C-terminal domain interface [polypeptide binding]; other site
320389006170	GSH binding site (G-site) [chemical binding]; other site
320389006171	dimer interface [polypeptide binding]; other site
320389006172	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
320389006173	putative N-terminal domain interface [polypeptide binding]; other site
320389006174	putative dimer interface [polypeptide binding]; other site
320389006175	putative substrate binding pocket (H-site) [chemical binding]; other site
320389006176	methionine aminotransferase; Validated; Region: PRK09082
320389006177	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389006178	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389006179	homodimer interface [polypeptide binding]; other site
320389006180	catalytic residue [active]
320389006181	PIN domain; Region: PIN_3; pfam13470
320389006182	PIN domain; Region: PIN_3; cl17397
320389006183	hypothetical protein; Validated; Region: PRK02101
320389006184	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
320389006185	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
320389006186	putative active site [active]
320389006187	Zn binding site [ion binding]; other site
320389006188	Predicted membrane protein [Function unknown]; Region: COG3235
320389006189	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389006190	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
320389006191	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389006192	DNA binding residues [nucleotide binding]
320389006193	dimerization interface [polypeptide binding]; other site
320389006194	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
320389006195	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
320389006196	Predicted transcriptional regulator [Transcription]; Region: COG1959
320389006197	Transcriptional regulator; Region: Rrf2; pfam02082
320389006198	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
320389006199	NADH(P)-binding; Region: NAD_binding_10; pfam13460
320389006200	NAD binding site [chemical binding]; other site
320389006201	putative active site [active]
320389006202	substrate binding site [chemical binding]; other site
320389006203	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389006204	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389006205	putative DNA binding site [nucleotide binding]; other site
320389006206	putative Zn2+ binding site [ion binding]; other site
320389006207	AsnC family; Region: AsnC_trans_reg; pfam01037
320389006208	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
320389006209	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
320389006210	Walker A/P-loop; other site
320389006211	ATP binding site [chemical binding]; other site
320389006212	Q-loop/lid; other site
320389006213	ABC transporter signature motif; other site
320389006214	Walker B; other site
320389006215	D-loop; other site
320389006216	H-loop/switch region; other site
320389006217	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
320389006218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006219	dimer interface [polypeptide binding]; other site
320389006220	conserved gate region; other site
320389006221	putative PBP binding loops; other site
320389006222	ABC-ATPase subunit interface; other site
320389006223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006224	ABC-ATPase subunit interface; other site
320389006225	putative PBP binding loops; other site
320389006226	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
320389006227	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
320389006228	putative proline-specific permease; Provisional; Region: proY; PRK10580
320389006229	Predicted membrane protein [Function unknown]; Region: COG1289
320389006230	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
320389006231	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
320389006232	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389006233	trimer interface [polypeptide binding]; other site
320389006234	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
320389006235	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
320389006236	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
320389006237	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
320389006238	Family description; Region: UvrD_C_2; pfam13538
320389006239	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
320389006240	AAA domain; Region: AAA_30; pfam13604
320389006241	Family description; Region: UvrD_C_2; pfam13538
320389006242	hypothetical protein; Provisional; Region: PRK09256
320389006243	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
320389006244	EamA-like transporter family; Region: EamA; pfam00892
320389006245	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
320389006246	EamA-like transporter family; Region: EamA; pfam00892
320389006247	Transposase; Region: HTH_Tnp_1; pfam01527
320389006248	HTH-like domain; Region: HTH_21; pfam13276
320389006249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006250	Integrase core domain; Region: rve; pfam00665
320389006251	Integrase core domain; Region: rve_3; pfam13683
320389006252	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
320389006253	ThiC-associated domain; Region: ThiC-associated; pfam13667
320389006254	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
320389006255	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
320389006256	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
320389006257	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
320389006258	Moco binding site; other site
320389006259	metal coordination site [ion binding]; other site
320389006260	EamA-like transporter family; Region: EamA; pfam00892
320389006261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006262	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
320389006263	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389006264	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389006265	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389006266	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
320389006267	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389006268	active site
320389006269	metal binding site [ion binding]; metal-binding site
320389006270	hexamer interface [polypeptide binding]; other site
320389006271	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
320389006272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389006273	Walker A/P-loop; other site
320389006274	ATP binding site [chemical binding]; other site
320389006275	Q-loop/lid; other site
320389006276	ABC transporter signature motif; other site
320389006277	Walker B; other site
320389006278	D-loop; other site
320389006279	H-loop/switch region; other site
320389006280	TOBE domain; Region: TOBE_2; pfam08402
320389006281	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
320389006282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006283	putative PBP binding loops; other site
320389006284	ABC-ATPase subunit interface; other site
320389006285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
320389006286	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
320389006287	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
320389006288	Transcriptional regulators [Transcription]; Region: PurR; COG1609
320389006289	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
320389006290	DNA binding site [nucleotide binding]
320389006291	domain linker motif; other site
320389006292	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
320389006293	putative dimerization interface [polypeptide binding]; other site
320389006294	putative ligand binding site [chemical binding]; other site
320389006295	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389006296	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389006297	metal binding site [ion binding]; metal-binding site
320389006298	active site
320389006299	I-site; other site
320389006300	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
320389006301	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
320389006302	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
320389006303	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
320389006304	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389006305	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389006306	DNA-binding site [nucleotide binding]; DNA binding site
320389006307	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389006308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389006309	homodimer interface [polypeptide binding]; other site
320389006310	catalytic residue [active]
320389006311	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389006312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389006313	putative DNA binding site [nucleotide binding]; other site
320389006314	putative Zn2+ binding site [ion binding]; other site
320389006315	AsnC family; Region: AsnC_trans_reg; pfam01037
320389006316	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
320389006317	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
320389006318	glutaminase active site [active]
320389006319	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
320389006320	dimer interface [polypeptide binding]; other site
320389006321	active site
320389006322	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
320389006323	dimer interface [polypeptide binding]; other site
320389006324	active site
320389006325	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
320389006326	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
320389006327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389006328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389006329	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
320389006330	putative effector binding pocket; other site
320389006331	putative dimerization interface [polypeptide binding]; other site
320389006332	short chain dehydrogenase; Provisional; Region: PRK12744
320389006333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389006334	NAD(P) binding site [chemical binding]; other site
320389006335	active site
320389006336	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
320389006337	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
320389006338	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389006339	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389006340	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
320389006341	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389006342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389006343	DNA-binding site [nucleotide binding]; DNA binding site
320389006344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389006345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389006346	homodimer interface [polypeptide binding]; other site
320389006347	catalytic residue [active]
320389006348	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
320389006349	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
320389006350	putative dimer interface [polypeptide binding]; other site
320389006351	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
320389006352	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
320389006353	putative dimer interface [polypeptide binding]; other site
320389006354	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
320389006355	active site
320389006356	substrate-binding site [chemical binding]; other site
320389006357	metal-binding site [ion binding]
320389006358	GTP binding site [chemical binding]; other site
320389006359	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389006360	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389006361	LysR substrate binding domain; Region: LysR_substrate; pfam03466
320389006362	dimerization interface [polypeptide binding]; other site
320389006363	Malonate transporter MadL subunit; Region: MadL; cl04273
320389006364	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
320389006365	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
320389006366	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
320389006367	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
320389006368	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
320389006369	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098
320389006370	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913
320389006371	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
320389006372	Acyl transferase domain; Region: Acyl_transf_1; cl08282
320389006373	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
320389006374	putative active site [active]
320389006375	catalytic site [active]
320389006376	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
320389006377	HTH-like domain; Region: HTH_21; pfam13276
320389006378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006379	Integrase core domain; Region: rve; pfam00665
320389006380	Integrase core domain; Region: rve_3; pfam13683
320389006381	Transposase; Region: HTH_Tnp_1; pfam01527
320389006382	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
320389006383	N-terminal domain interface [polypeptide binding]; other site
320389006384	proline/glycine betaine transporter; Provisional; Region: PRK10642
320389006385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006386	putative substrate translocation pore; other site
320389006387	hypothetical protein; Provisional; Region: PRK02237
320389006388	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
320389006389	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
320389006390	active site
320389006391	catalytic site [active]
320389006392	substrate binding site [chemical binding]; other site
320389006393	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
320389006394	RNA/DNA hybrid binding site [nucleotide binding]; other site
320389006395	active site
320389006396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389006397	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
320389006398	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
320389006399	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
320389006400	N-acetyl-D-glucosamine binding site [chemical binding]; other site
320389006401	catalytic residue [active]
320389006402	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
320389006403	Lysin motif; Region: LysM; smart00257
320389006404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006405	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389006406	putative substrate translocation pore; other site
320389006407	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
320389006408	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389006409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389006410	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
320389006411	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
320389006412	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
320389006413	catalytic site [active]
320389006414	subunit interface [polypeptide binding]; other site
320389006415	leucine export protein LeuE; Provisional; Region: PRK10958
320389006416	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
320389006417	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
320389006418	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
320389006419	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
320389006420	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
320389006421	ATP-grasp domain; Region: ATP-grasp_4; cl17255
320389006422	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
320389006423	IMP binding site; other site
320389006424	dimer interface [polypeptide binding]; other site
320389006425	interdomain contacts; other site
320389006426	partial ornithine binding site; other site
320389006427	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
320389006428	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
320389006429	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
320389006430	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
320389006431	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
320389006432	FtsJ-like methyltransferase; Region: FtsJ; cl17430
320389006433	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
320389006434	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
320389006435	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389006436	Walker A motif; other site
320389006437	ATP binding site [chemical binding]; other site
320389006438	Walker B motif; other site
320389006439	arginine finger; other site
320389006440	Peptidase family M41; Region: Peptidase_M41; pfam01434
320389006441	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
320389006442	dihydropteroate synthase; Region: DHPS; TIGR01496
320389006443	substrate binding pocket [chemical binding]; other site
320389006444	dimer interface [polypeptide binding]; other site
320389006445	inhibitor binding site; inhibition site
320389006446	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
320389006447	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
320389006448	active site
320389006449	substrate binding site [chemical binding]; other site
320389006450	metal binding site [ion binding]; metal-binding site
320389006451	PBP superfamily domain; Region: PBP_like_2; cl17296
320389006452	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
320389006453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006454	dimer interface [polypeptide binding]; other site
320389006455	conserved gate region; other site
320389006456	putative PBP binding loops; other site
320389006457	ABC-ATPase subunit interface; other site
320389006458	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
320389006459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006460	dimer interface [polypeptide binding]; other site
320389006461	conserved gate region; other site
320389006462	putative PBP binding loops; other site
320389006463	ABC-ATPase subunit interface; other site
320389006464	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
320389006465	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
320389006466	Walker A/P-loop; other site
320389006467	ATP binding site [chemical binding]; other site
320389006468	Q-loop/lid; other site
320389006469	ABC transporter signature motif; other site
320389006470	Walker B; other site
320389006471	D-loop; other site
320389006472	H-loop/switch region; other site
320389006473	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
320389006474	PhoU domain; Region: PhoU; pfam01895
320389006475	PhoU domain; Region: PhoU; pfam01895
320389006476	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
320389006477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389006478	active site
320389006479	phosphorylation site [posttranslational modification]
320389006480	intermolecular recognition site; other site
320389006481	dimerization interface [polypeptide binding]; other site
320389006482	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389006483	DNA binding site [nucleotide binding]
320389006484	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
320389006485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389006486	dimer interface [polypeptide binding]; other site
320389006487	phosphorylation site [posttranslational modification]
320389006488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389006489	ATP binding site [chemical binding]; other site
320389006490	Mg2+ binding site [ion binding]; other site
320389006491	G-X-G motif; other site
320389006492	polyphosphate kinase; Provisional; Region: PRK05443
320389006493	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
320389006494	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
320389006495	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
320389006496	putative active site [active]
320389006497	catalytic site [active]
320389006498	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
320389006499	putative domain interface [polypeptide binding]; other site
320389006500	putative active site [active]
320389006501	catalytic site [active]
320389006502	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
320389006503	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
320389006504	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
320389006505	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
320389006506	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
320389006507	catalytic core [active]
320389006508	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
320389006509	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
320389006510	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
320389006511	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
320389006512	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
320389006513	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
320389006514	active site
320389006515	acyl-activating enzyme (AAE) consensus motif; other site
320389006516	putative CoA binding site [chemical binding]; other site
320389006517	AMP binding site [chemical binding]; other site
320389006518	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
320389006519	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
320389006520	Peptidase family M23; Region: Peptidase_M23; pfam01551
320389006521	Transposase; Region: HTH_Tnp_1; pfam01527
320389006522	HTH-like domain; Region: HTH_21; pfam13276
320389006523	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006524	Integrase core domain; Region: rve; pfam00665
320389006525	Integrase core domain; Region: rve_3; pfam13683
320389006526	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
320389006527	PAAR motif; Region: PAAR_motif; pfam05488
320389006528	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
320389006529	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
320389006530	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
320389006531	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
320389006532	Leucine carboxyl methyltransferase; Region: LCM; cl01306
320389006533	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
320389006534	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389006535	DNA-binding site [nucleotide binding]; DNA binding site
320389006536	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389006537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389006538	homodimer interface [polypeptide binding]; other site
320389006539	catalytic residue [active]
320389006540	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
320389006541	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
320389006542	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
320389006543	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
320389006544	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
320389006545	active site
320389006546	catalytic site [active]
320389006547	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
320389006548	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
320389006549	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
320389006550	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
320389006551	catalytic site [active]
320389006552	active site
320389006553	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
320389006554	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
320389006555	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
320389006556	active site
320389006557	catalytic site [active]
320389006558	trehalose synthase; Region: treS_nterm; TIGR02456
320389006559	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
320389006560	active site
320389006561	catalytic site [active]
320389006562	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
320389006563	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
320389006564	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
320389006565	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
320389006566	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
320389006567	active site
320389006568	homodimer interface [polypeptide binding]; other site
320389006569	catalytic site [active]
320389006570	acceptor binding site [chemical binding]; other site
320389006571	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
320389006572	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
320389006573	Interdomain contacts; other site
320389006574	Cytokine receptor motif; other site
320389006575	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
320389006576	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389006577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389006578	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389006579	dimerization interface [polypeptide binding]; other site
320389006580	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389006581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389006582	active site
320389006583	phosphorylation site [posttranslational modification]
320389006584	intermolecular recognition site; other site
320389006585	dimerization interface [polypeptide binding]; other site
320389006586	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389006587	DNA binding site [nucleotide binding]
320389006588	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
320389006589	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
320389006590	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389006591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389006592	active site
320389006593	phosphorylation site [posttranslational modification]
320389006594	intermolecular recognition site; other site
320389006595	dimerization interface [polypeptide binding]; other site
320389006596	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389006597	DNA binding site [nucleotide binding]
320389006598	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
320389006599	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
320389006600	trimer interface [polypeptide binding]; other site
320389006601	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
320389006602	trimer interface [polypeptide binding]; other site
320389006603	YadA-like C-terminal region; Region: YadA; pfam03895
320389006604	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389006605	ligand binding site [chemical binding]; other site
320389006606	TPR repeat; Region: TPR_11; pfam13414
320389006607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389006608	binding surface
320389006609	TPR motif; other site
320389006610	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
320389006611	H-NS histone family; Region: Histone_HNS; pfam00816
320389006612	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389006613	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
320389006614	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
320389006615	Cu(I) binding site [ion binding]; other site
320389006616	Ricin-type beta-trefoil; Region: RICIN; smart00458
320389006617	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
320389006618	putative sugar binding sites [chemical binding]; other site
320389006619	Q-X-W motif; other site
320389006620	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
320389006621	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
320389006622	Galactose oxidase, central domain; Region: Kelch_3; cl02701
320389006623	Kelch motif; Region: Kelch_6; pfam13964
320389006624	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
320389006625	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
320389006626	PAAR motif; Region: PAAR_motif; pfam05488
320389006627	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
320389006628	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
320389006629	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
320389006630	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
320389006631	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
320389006632	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
320389006633	HTH-like domain; Region: HTH_21; pfam13276
320389006634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006635	Integrase core domain; Region: rve; pfam00665
320389006636	Integrase core domain; Region: rve_3; pfam13683
320389006637	Transposase; Region: HTH_Tnp_1; pfam01527
320389006638	manganese transport protein MntH; Reviewed; Region: PRK00701
320389006639	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
320389006640	H-NS histone family; Region: Histone_HNS; pfam00816
320389006641	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389006642	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
320389006643	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389006644	active site
320389006645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006646	putative substrate translocation pore; other site
320389006647	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
320389006648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389006649	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
320389006650	dimerization interface [polypeptide binding]; other site
320389006651	substrate binding pocket [chemical binding]; other site
320389006652	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389006653	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389006654	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389006655	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
320389006656	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
320389006657	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389006658	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389006659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389006660	dimer interface [polypeptide binding]; other site
320389006661	phosphorylation site [posttranslational modification]
320389006662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389006663	ATP binding site [chemical binding]; other site
320389006664	Mg2+ binding site [ion binding]; other site
320389006665	G-X-G motif; other site
320389006666	Response regulator receiver domain; Region: Response_reg; pfam00072
320389006667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389006668	active site
320389006669	phosphorylation site [posttranslational modification]
320389006670	intermolecular recognition site; other site
320389006671	dimerization interface [polypeptide binding]; other site
320389006672	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389006673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389006674	active site
320389006675	phosphorylation site [posttranslational modification]
320389006676	intermolecular recognition site; other site
320389006677	dimerization interface [polypeptide binding]; other site
320389006678	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389006679	DNA binding residues [nucleotide binding]
320389006680	dimerization interface [polypeptide binding]; other site
320389006681	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389006682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006683	putative substrate translocation pore; other site
320389006684	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
320389006685	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389006686	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389006687	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
320389006688	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
320389006689	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
320389006690	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
320389006691	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
320389006692	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
320389006693	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
320389006694	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
320389006695	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
320389006696	nudix motif; other site
320389006697	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
320389006698	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
320389006699	active site
320389006700	HIGH motif; other site
320389006701	nucleotide binding site [chemical binding]; other site
320389006702	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
320389006703	KMSKS motif; other site
320389006704	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
320389006705	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
320389006706	CoA-transferase family III; Region: CoA_transf_3; pfam02515
320389006707	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
320389006708	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
320389006709	motif 1; other site
320389006710	active site
320389006711	motif 2; other site
320389006712	motif 3; other site
320389006713	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
320389006714	DHHA1 domain; Region: DHHA1; pfam02272
320389006715	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389006716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389006717	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389006718	dimerization interface [polypeptide binding]; other site
320389006719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006720	Transposase; Region: HTH_Tnp_1; pfam01527
320389006721	HTH-like domain; Region: HTH_21; pfam13276
320389006722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006723	Integrase core domain; Region: rve; pfam00665
320389006724	Integrase core domain; Region: rve_3; pfam13683
320389006725	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
320389006726	nudix motif; other site
320389006727	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
320389006728	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
320389006729	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
320389006730	putative active site [active]
320389006731	metal binding site [ion binding]; metal-binding site
320389006732	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
320389006733	active site
320389006734	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
320389006735	TM-ABC transporter signature motif; other site
320389006736	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
320389006737	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
320389006738	TM-ABC transporter signature motif; other site
320389006739	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
320389006740	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
320389006741	Walker A/P-loop; other site
320389006742	ATP binding site [chemical binding]; other site
320389006743	Q-loop/lid; other site
320389006744	ABC transporter signature motif; other site
320389006745	Walker B; other site
320389006746	D-loop; other site
320389006747	H-loop/switch region; other site
320389006748	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
320389006749	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
320389006750	Walker A/P-loop; other site
320389006751	ATP binding site [chemical binding]; other site
320389006752	Q-loop/lid; other site
320389006753	ABC transporter signature motif; other site
320389006754	Walker B; other site
320389006755	D-loop; other site
320389006756	H-loop/switch region; other site
320389006757	KduI/IolB family; Region: KduI; pfam04962
320389006758	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
320389006759	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
320389006760	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
320389006761	PYR/PP interface [polypeptide binding]; other site
320389006762	dimer interface [polypeptide binding]; other site
320389006763	TPP binding site [chemical binding]; other site
320389006764	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389006765	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
320389006766	TPP-binding site [chemical binding]; other site
320389006767	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
320389006768	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
320389006769	substrate binding site [chemical binding]; other site
320389006770	ATP binding site [chemical binding]; other site
320389006771	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
320389006772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
320389006773	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
320389006774	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
320389006775	Walker A/P-loop; other site
320389006776	ATP binding site [chemical binding]; other site
320389006777	Q-loop/lid; other site
320389006778	ABC transporter signature motif; other site
320389006779	Walker B; other site
320389006780	D-loop; other site
320389006781	H-loop/switch region; other site
320389006782	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389006783	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
320389006784	TM-ABC transporter signature motif; other site
320389006785	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
320389006786	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
320389006787	putative ligand binding site [chemical binding]; other site
320389006788	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389006789	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389006790	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
320389006791	putative active site [active]
320389006792	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
320389006793	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
320389006794	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
320389006795	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
320389006796	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
320389006797	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
320389006798	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
320389006799	CPxP  motif; other site
320389006800	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389006801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389006802	active site
320389006803	phosphorylation site [posttranslational modification]
320389006804	intermolecular recognition site; other site
320389006805	dimerization interface [polypeptide binding]; other site
320389006806	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389006807	DNA binding site [nucleotide binding]
320389006808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
320389006809	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
320389006810	FecR protein; Region: FecR; pfam04773
320389006811	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
320389006812	CHASE2 domain; Region: CHASE2; pfam05226
320389006813	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
320389006814	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389006815	dimer interface [polypeptide binding]; other site
320389006816	phosphorylation site [posttranslational modification]
320389006817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389006818	ATP binding site [chemical binding]; other site
320389006819	Mg2+ binding site [ion binding]; other site
320389006820	G-X-G motif; other site
320389006821	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
320389006822	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
320389006823	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
320389006824	active site
320389006825	tetramer interface; other site
320389006826	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
320389006827	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
320389006828	HIGH motif; other site
320389006829	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
320389006830	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
320389006831	active site
320389006832	KMSKS motif; other site
320389006833	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
320389006834	tRNA binding surface [nucleotide binding]; other site
320389006835	anticodon binding site; other site
320389006836	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
320389006837	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
320389006838	Part of AAA domain; Region: AAA_19; pfam13245
320389006839	Family description; Region: UvrD_C_2; pfam13538
320389006840	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
320389006841	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
320389006842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389006843	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389006844	putative substrate translocation pore; other site
320389006845	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
320389006846	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389006847	dimer interface [polypeptide binding]; other site
320389006848	putative CheW interface [polypeptide binding]; other site
320389006849	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
320389006850	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389006851	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389006852	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
320389006853	Fusaric acid resistance protein family; Region: FUSC; pfam04632
320389006854	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
320389006855	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
320389006856	transcriptional regulator; Provisional; Region: PRK10632
320389006857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389006858	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389006859	putative effector binding pocket; other site
320389006860	dimerization interface [polypeptide binding]; other site
320389006861	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389006862	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
320389006863	active site
320389006864	metal binding site [ion binding]; metal-binding site
320389006865	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
320389006866	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
320389006867	FAD binding domain; Region: FAD_binding_4; pfam01565
320389006868	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
320389006869	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
320389006870	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
320389006871	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
320389006872	Protein of unknown function (DUF962); Region: DUF962; cl01879
320389006873	FOG: CBS domain [General function prediction only]; Region: COG0517
320389006874	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
320389006875	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
320389006876	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
320389006877	Tetramer interface [polypeptide binding]; other site
320389006878	active site
320389006879	FMN-binding site [chemical binding]; other site
320389006880	HTH-like domain; Region: HTH_21; pfam13276
320389006881	HTH-like domain; Region: HTH_21; pfam13276
320389006882	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006883	Integrase core domain; Region: rve; pfam00665
320389006884	Integrase core domain; Region: rve_3; pfam13683
320389006885	Transposase; Region: HTH_Tnp_1; pfam01527
320389006886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006887	dimer interface [polypeptide binding]; other site
320389006888	conserved gate region; other site
320389006889	putative PBP binding loops; other site
320389006890	ABC-ATPase subunit interface; other site
320389006891	cystine transporter subunit; Provisional; Region: PRK11260
320389006892	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389006893	substrate binding pocket [chemical binding]; other site
320389006894	membrane-bound complex binding site; other site
320389006895	hinge residues; other site
320389006896	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
320389006897	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
320389006898	quinone interaction residues [chemical binding]; other site
320389006899	active site
320389006900	catalytic residues [active]
320389006901	FMN binding site [chemical binding]; other site
320389006902	substrate binding site [chemical binding]; other site
320389006903	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
320389006904	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
320389006905	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
320389006906	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
320389006907	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
320389006908	nudix motif; other site
320389006909	hypothetical protein; Provisional; Region: PRK02487
320389006910	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
320389006911	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
320389006912	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389006913	substrate binding site [chemical binding]; other site
320389006914	oxyanion hole (OAH) forming residues; other site
320389006915	trimer interface [polypeptide binding]; other site
320389006916	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
320389006917	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
320389006918	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
320389006919	active site
320389006920	dimer interface [polypeptide binding]; other site
320389006921	non-prolyl cis peptide bond; other site
320389006922	insertion regions; other site
320389006923	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
320389006924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006925	dimer interface [polypeptide binding]; other site
320389006926	conserved gate region; other site
320389006927	putative PBP binding loops; other site
320389006928	ABC-ATPase subunit interface; other site
320389006929	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
320389006930	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
320389006931	Walker A/P-loop; other site
320389006932	ATP binding site [chemical binding]; other site
320389006933	Q-loop/lid; other site
320389006934	ABC transporter signature motif; other site
320389006935	Walker B; other site
320389006936	D-loop; other site
320389006937	H-loop/switch region; other site
320389006938	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
320389006939	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389006940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389006941	Transposase; Region: HTH_Tnp_1; pfam01527
320389006942	HTH-like domain; Region: HTH_21; pfam13276
320389006943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389006944	Integrase core domain; Region: rve; pfam00665
320389006945	Integrase core domain; Region: rve_3; pfam13683
320389006946	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
320389006947	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
320389006948	FMN binding site [chemical binding]; other site
320389006949	active site
320389006950	catalytic residues [active]
320389006951	substrate binding site [chemical binding]; other site
320389006952	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
320389006953	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
320389006954	Predicted transcriptional regulators [Transcription]; Region: COG1733
320389006955	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
320389006956	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
320389006957	CoenzymeA binding site [chemical binding]; other site
320389006958	subunit interaction site [polypeptide binding]; other site
320389006959	PHB binding site; other site
320389006960	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
320389006961	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
320389006962	active site
320389006963	catalytic tetrad [active]
320389006964	Predicted permease; Region: DUF318; cl17795
320389006965	ABC-2 type transporter; Region: ABC2_membrane; cl17235
320389006966	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
320389006967	nodulation ABC transporter NodI; Provisional; Region: PRK13537
320389006968	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
320389006969	Walker A/P-loop; other site
320389006970	ATP binding site [chemical binding]; other site
320389006971	Q-loop/lid; other site
320389006972	ABC transporter signature motif; other site
320389006973	Walker B; other site
320389006974	D-loop; other site
320389006975	H-loop/switch region; other site
320389006976	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389006977	Ligand Binding Site [chemical binding]; other site
320389006978	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
320389006979	LexA repressor; Validated; Region: PRK00215
320389006980	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
320389006981	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
320389006982	Catalytic site [active]
320389006983	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
320389006984	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389006985	substrate binding pocket [chemical binding]; other site
320389006986	membrane-bound complex binding site; other site
320389006987	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
320389006988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006989	dimer interface [polypeptide binding]; other site
320389006990	conserved gate region; other site
320389006991	putative PBP binding loops; other site
320389006992	ABC-ATPase subunit interface; other site
320389006993	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
320389006994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389006995	dimer interface [polypeptide binding]; other site
320389006996	conserved gate region; other site
320389006997	putative PBP binding loops; other site
320389006998	ABC-ATPase subunit interface; other site
320389006999	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
320389007000	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
320389007001	Walker A/P-loop; other site
320389007002	ATP binding site [chemical binding]; other site
320389007003	Q-loop/lid; other site
320389007004	ABC transporter signature motif; other site
320389007005	Walker B; other site
320389007006	D-loop; other site
320389007007	H-loop/switch region; other site
320389007008	TOBE-like domain; Region: TOBE_3; pfam12857
320389007009	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
320389007010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389007011	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
320389007012	substrate binding site [chemical binding]; other site
320389007013	dimerization interface [polypeptide binding]; other site
320389007014	Transposase; Region: HTH_Tnp_1; pfam01527
320389007015	HTH-like domain; Region: HTH_21; pfam13276
320389007016	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389007017	Integrase core domain; Region: rve; pfam00665
320389007018	Integrase core domain; Region: rve_3; pfam13683
320389007019	PrkA family serine protein kinase; Provisional; Region: PRK15455
320389007020	AAA ATPase domain; Region: AAA_16; pfam13191
320389007021	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
320389007022	hypothetical protein; Provisional; Region: PRK05325
320389007023	SpoVR family protein; Provisional; Region: PRK11767
320389007024	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
320389007025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389007026	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
320389007027	putative substrate translocation pore; other site
320389007028	NMT1-like family; Region: NMT1_2; pfam13379
320389007029	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
320389007030	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
320389007031	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
320389007032	Walker A/P-loop; other site
320389007033	ATP binding site [chemical binding]; other site
320389007034	Q-loop/lid; other site
320389007035	ABC transporter signature motif; other site
320389007036	Walker B; other site
320389007037	D-loop; other site
320389007038	H-loop/switch region; other site
320389007039	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
320389007040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
320389007041	Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177
320389007042	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
320389007043	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
320389007044	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389007045	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
320389007046	AAA domain; Region: AAA_31; pfam13614
320389007047	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
320389007048	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
320389007049	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
320389007050	ATP binding site [chemical binding]; other site
320389007051	Walker A motif; other site
320389007052	hexamer interface [polypeptide binding]; other site
320389007053	Walker B motif; other site
320389007054	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
320389007055	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389007056	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
320389007057	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389007058	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
320389007059	TadE-like protein; Region: TadE; pfam07811
320389007060	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389007061	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389007062	substrate binding pocket [chemical binding]; other site
320389007063	membrane-bound complex binding site; other site
320389007064	hinge residues; other site
320389007065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389007066	dimer interface [polypeptide binding]; other site
320389007067	conserved gate region; other site
320389007068	putative PBP binding loops; other site
320389007069	ABC-ATPase subunit interface; other site
320389007070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389007071	dimer interface [polypeptide binding]; other site
320389007072	conserved gate region; other site
320389007073	putative PBP binding loops; other site
320389007074	ABC-ATPase subunit interface; other site
320389007075	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
320389007076	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389007077	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
320389007078	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
320389007079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389007080	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389007081	PapC C-terminal domain; Region: PapC_C; pfam13953
320389007082	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
320389007083	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
320389007084	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
320389007085	Fimbrial protein; Region: Fimbrial; pfam00419
320389007086	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
320389007087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389007088	Walker A/P-loop; other site
320389007089	ATP binding site [chemical binding]; other site
320389007090	Q-loop/lid; other site
320389007091	ABC transporter signature motif; other site
320389007092	Walker B; other site
320389007093	D-loop; other site
320389007094	H-loop/switch region; other site
320389007095	Transposase; Region: HTH_Tnp_1; pfam01527
320389007096	HTH-like domain; Region: HTH_21; pfam13276
320389007097	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389007098	Integrase core domain; Region: rve; pfam00665
320389007099	Integrase core domain; Region: rve_3; pfam13683
320389007100	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
320389007101	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389007102	Helix-turn-helix domain; Region: HTH_18; pfam12833
320389007103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389007104	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
320389007105	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
320389007106	putative ligand binding site [chemical binding]; other site
320389007107	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
320389007108	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
320389007109	Walker A/P-loop; other site
320389007110	ATP binding site [chemical binding]; other site
320389007111	Q-loop/lid; other site
320389007112	ABC transporter signature motif; other site
320389007113	Walker B; other site
320389007114	D-loop; other site
320389007115	H-loop/switch region; other site
320389007116	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
320389007117	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
320389007118	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389007119	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
320389007120	TM-ABC transporter signature motif; other site
320389007121	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
320389007122	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
320389007123	NAD(P) binding site [chemical binding]; other site
320389007124	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
320389007125	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
320389007126	N- and C-terminal domain interface [polypeptide binding]; other site
320389007127	putative active site [active]
320389007128	MgATP binding site [chemical binding]; other site
320389007129	catalytic site [active]
320389007130	metal binding site [ion binding]; metal-binding site
320389007131	putative xylulose binding site [chemical binding]; other site
320389007132	putative homodimer interface [polypeptide binding]; other site
320389007133	short chain dehydrogenase; Provisional; Region: PRK07060
320389007134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389007135	NAD(P) binding site [chemical binding]; other site
320389007136	active site
320389007137	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
320389007138	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389007139	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
320389007140	DNA binding residues [nucleotide binding]
320389007141	MbtH-like protein; Region: MbtH; cl01279
320389007142	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
320389007143	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
320389007144	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
320389007145	Walker A/P-loop; other site
320389007146	ATP binding site [chemical binding]; other site
320389007147	Q-loop/lid; other site
320389007148	ABC transporter signature motif; other site
320389007149	Walker B; other site
320389007150	D-loop; other site
320389007151	H-loop/switch region; other site
320389007152	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
320389007153	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
320389007154	dimer interface [polypeptide binding]; other site
320389007155	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
320389007156	ABC-ATPase subunit  interface; other site
320389007157	dimer interface [polypeptide binding]; other site
320389007158	putative PBP binding regions; other site
320389007159	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
320389007160	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
320389007161	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
320389007162	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
320389007163	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
320389007164	siderophore binding site; other site
320389007165	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
320389007166	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
320389007167	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
320389007168	Walker A/P-loop; other site
320389007169	ATP binding site [chemical binding]; other site
320389007170	Q-loop/lid; other site
320389007171	ABC transporter signature motif; other site
320389007172	Walker B; other site
320389007173	D-loop; other site
320389007174	H-loop/switch region; other site
320389007175	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389007176	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
320389007177	acyl-activating enzyme (AAE) consensus motif; other site
320389007178	AMP binding site [chemical binding]; other site
320389007179	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389007180	Condensation domain; Region: Condensation; pfam00668
320389007181	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
320389007182	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
320389007183	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389007184	acyl-activating enzyme (AAE) consensus motif; other site
320389007185	AMP binding site [chemical binding]; other site
320389007186	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389007187	Condensation domain; Region: Condensation; pfam00668
320389007188	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
320389007189	Condensation domain; Region: Condensation; pfam00668
320389007190	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
320389007191	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389007192	acyl-activating enzyme (AAE) consensus motif; other site
320389007193	AMP binding site [chemical binding]; other site
320389007194	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389007195	Condensation domain; Region: Condensation; pfam00668
320389007196	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
320389007197	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389007198	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
320389007199	acyl-activating enzyme (AAE) consensus motif; other site
320389007200	AMP binding site [chemical binding]; other site
320389007201	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389007202	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
320389007203	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
320389007204	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389007205	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
320389007206	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389007207	N-terminal plug; other site
320389007208	ligand-binding site [chemical binding]; other site
320389007209	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
320389007210	catalytic site [active]
320389007211	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
320389007212	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
320389007213	catalytic triad [active]
320389007214	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
320389007215	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
320389007216	homodimer interface [polypeptide binding]; other site
320389007217	Walker A motif; other site
320389007218	ATP binding site [chemical binding]; other site
320389007219	hydroxycobalamin binding site [chemical binding]; other site
320389007220	Walker B motif; other site
320389007221	High-affinity nickel-transport protein; Region: NicO; cl00964
320389007222	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
320389007223	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
320389007224	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
320389007225	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
320389007226	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
320389007227	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
320389007228	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
320389007229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389007230	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
320389007231	Walker A motif; other site
320389007232	ATP binding site [chemical binding]; other site
320389007233	Walker B motif; other site
320389007234	arginine finger; other site
320389007235	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
320389007236	metal ion-dependent adhesion site (MIDAS); other site
320389007237	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
320389007238	active site
320389007239	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
320389007240	aromatic chitin/cellulose binding site residues [chemical binding]; other site
320389007241	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
320389007242	aromatic chitin/cellulose binding site residues [chemical binding]; other site
320389007243	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
320389007244	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
320389007245	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
320389007246	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
320389007247	active site
320389007248	SAM binding site [chemical binding]; other site
320389007249	homodimer interface [polypeptide binding]; other site
320389007250	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
320389007251	active site
320389007252	SAM binding site [chemical binding]; other site
320389007253	homodimer interface [polypeptide binding]; other site
320389007254	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
320389007255	Precorrin-8X methylmutase; Region: CbiC; pfam02570
320389007256	precorrin-3B synthase; Region: CobG; TIGR02435
320389007257	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389007258	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389007259	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
320389007260	active site
320389007261	putative homodimer interface [polypeptide binding]; other site
320389007262	SAM binding site [chemical binding]; other site
320389007263	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
320389007264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389007265	S-adenosylmethionine binding site [chemical binding]; other site
320389007266	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
320389007267	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
320389007268	active site
320389007269	SAM binding site [chemical binding]; other site
320389007270	homodimer interface [polypeptide binding]; other site
320389007271	MarR family; Region: MarR_2; cl17246
320389007272	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389007273	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
320389007274	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
320389007275	dimerization interface [polypeptide binding]; other site
320389007276	ligand binding site [chemical binding]; other site
320389007277	Transcriptional regulators [Transcription]; Region: MarR; COG1846
320389007278	MarR family; Region: MarR_2; pfam12802
320389007279	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
320389007280	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
320389007281	C-terminal domain interface [polypeptide binding]; other site
320389007282	GSH binding site (G-site) [chemical binding]; other site
320389007283	dimer interface [polypeptide binding]; other site
320389007284	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
320389007285	dimer interface [polypeptide binding]; other site
320389007286	N-terminal domain interface [polypeptide binding]; other site
320389007287	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389007288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389007289	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
320389007290	putative effector binding pocket; other site
320389007291	putative dimerization interface [polypeptide binding]; other site
320389007292	Domain of unknown function (DUF336); Region: DUF336; pfam03928
320389007293	short chain dehydrogenase; Provisional; Region: PRK09291
320389007294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389007295	NAD(P) binding site [chemical binding]; other site
320389007296	active site
320389007297	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
320389007298	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
320389007299	putative substrate binding site [chemical binding]; other site
320389007300	nucleotide binding site [chemical binding]; other site
320389007301	nucleotide binding site [chemical binding]; other site
320389007302	homodimer interface [polypeptide binding]; other site
320389007303	ornithine carbamoyltransferase; Validated; Region: PRK02102
320389007304	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
320389007305	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
320389007306	arginine deiminase; Provisional; Region: PRK01388
320389007307	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
320389007308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389007309	ABC-ATPase subunit interface; other site
320389007310	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
320389007311	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389007312	Walker A/P-loop; other site
320389007313	ATP binding site [chemical binding]; other site
320389007314	Q-loop/lid; other site
320389007315	ABC transporter signature motif; other site
320389007316	Walker B; other site
320389007317	D-loop; other site
320389007318	H-loop/switch region; other site
320389007319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389007320	dimer interface [polypeptide binding]; other site
320389007321	conserved gate region; other site
320389007322	putative PBP binding loops; other site
320389007323	ABC-ATPase subunit interface; other site
320389007324	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
320389007325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389007326	putative substrate translocation pore; other site
320389007327	AMP-binding domain protein; Validated; Region: PRK07529
320389007328	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389007329	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
320389007330	acyl-activating enzyme (AAE) consensus motif; other site
320389007331	putative AMP binding site [chemical binding]; other site
320389007332	putative active site [active]
320389007333	putative CoA binding site [chemical binding]; other site
320389007334	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
320389007335	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389007336	dimer interface [polypeptide binding]; other site
320389007337	putative CheW interface [polypeptide binding]; other site
320389007338	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
320389007339	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389007340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389007341	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389007342	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389007343	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389007344	trimer interface [polypeptide binding]; other site
320389007345	eyelet of channel; other site
320389007346	Cupin-like domain; Region: Cupin_8; pfam13621
320389007347	HTH-like domain; Region: HTH_21; pfam13276
320389007348	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389007349	Integrase core domain; Region: rve; pfam00665
320389007350	Integrase core domain; Region: rve_3; pfam13683
320389007351	Transposase; Region: HTH_Tnp_1; pfam01527
320389007352	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
320389007353	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
320389007354	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
320389007355	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
320389007356	short chain dehydrogenase; Provisional; Region: PRK06949
320389007357	classical (c) SDRs; Region: SDR_c; cd05233
320389007358	NAD(P) binding site [chemical binding]; other site
320389007359	active site
320389007360	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
320389007361	active site
320389007362	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
320389007363	PAS domain; Region: PAS_9; pfam13426
320389007364	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389007365	putative active site [active]
320389007366	heme pocket [chemical binding]; other site
320389007367	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389007368	DNA binding residues [nucleotide binding]
320389007369	dimerization interface [polypeptide binding]; other site
320389007370	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
320389007371	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
320389007372	short chain dehydrogenase; Provisional; Region: PRK07041
320389007373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389007374	NAD(P) binding site [chemical binding]; other site
320389007375	active site
320389007376	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
320389007377	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
320389007378	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
320389007379	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389007380	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
320389007381	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
320389007382	homotrimer interaction site [polypeptide binding]; other site
320389007383	putative active site [active]
320389007384	HD domain; Region: HD_4; pfam13328
320389007385	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
320389007386	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
320389007387	synthetase active site [active]
320389007388	NTP binding site [chemical binding]; other site
320389007389	metal binding site [ion binding]; metal-binding site
320389007390	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
320389007391	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
320389007392	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
320389007393	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
320389007394	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
320389007395	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
320389007396	active site
320389007397	dimer interface [polypeptide binding]; other site
320389007398	motif 1; other site
320389007399	motif 2; other site
320389007400	motif 3; other site
320389007401	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
320389007402	anticodon binding site; other site
320389007403	translation initiation factor IF-3; Region: infC; TIGR00168
320389007404	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
320389007405	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
320389007406	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
320389007407	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
320389007408	23S rRNA binding site [nucleotide binding]; other site
320389007409	L21 binding site [polypeptide binding]; other site
320389007410	L13 binding site [polypeptide binding]; other site
320389007411	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
320389007412	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
320389007413	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
320389007414	dimer interface [polypeptide binding]; other site
320389007415	motif 1; other site
320389007416	active site
320389007417	motif 2; other site
320389007418	motif 3; other site
320389007419	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
320389007420	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
320389007421	putative tRNA-binding site [nucleotide binding]; other site
320389007422	B3/4 domain; Region: B3_4; pfam03483
320389007423	tRNA synthetase B5 domain; Region: B5; smart00874
320389007424	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
320389007425	dimer interface [polypeptide binding]; other site
320389007426	motif 1; other site
320389007427	motif 3; other site
320389007428	motif 2; other site
320389007429	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
320389007430	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
320389007431	IHF dimer interface [polypeptide binding]; other site
320389007432	IHF - DNA interface [nucleotide binding]; other site
320389007433	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
320389007434	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
320389007435	DNA binding residues [nucleotide binding]
320389007436	Domain of unknown function (DUF811); Region: DUF811; pfam05665
320389007437	Domain of unknown function (DUF811); Region: DUF811; pfam05665
320389007438	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
320389007439	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
320389007440	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
320389007441	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
320389007442	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
320389007443	HTH-like domain; Region: HTH_21; pfam13276
320389007444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389007445	Integrase core domain; Region: rve; pfam00665
320389007446	Integrase core domain; Region: rve_3; pfam13683
320389007447	Transposase; Region: HTH_Tnp_1; pfam01527
320389007448	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
320389007449	outer membrane protein A; Reviewed; Region: PRK10808
320389007450	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
320389007451	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389007452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389007453	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
320389007454	putative dimerization interface [polypeptide binding]; other site
320389007455	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
320389007456	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
320389007457	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389007458	RNA binding surface [nucleotide binding]; other site
320389007459	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
320389007460	probable active site [active]
320389007461	ribosome maturation protein RimP; Reviewed; Region: PRK00092
320389007462	Sm and related proteins; Region: Sm_like; cl00259
320389007463	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
320389007464	putative oligomer interface [polypeptide binding]; other site
320389007465	putative RNA binding site [nucleotide binding]; other site
320389007466	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
320389007467	NusA N-terminal domain; Region: NusA_N; pfam08529
320389007468	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
320389007469	RNA binding site [nucleotide binding]; other site
320389007470	homodimer interface [polypeptide binding]; other site
320389007471	NusA-like KH domain; Region: KH_5; pfam13184
320389007472	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
320389007473	G-X-X-G motif; other site
320389007474	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
320389007475	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
320389007476	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
320389007477	translation initiation factor IF-2; Region: IF-2; TIGR00487
320389007478	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
320389007479	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
320389007480	G1 box; other site
320389007481	putative GEF interaction site [polypeptide binding]; other site
320389007482	GTP/Mg2+ binding site [chemical binding]; other site
320389007483	Switch I region; other site
320389007484	G2 box; other site
320389007485	G3 box; other site
320389007486	Switch II region; other site
320389007487	G4 box; other site
320389007488	G5 box; other site
320389007489	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
320389007490	Translation-initiation factor 2; Region: IF-2; pfam11987
320389007491	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
320389007492	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
320389007493	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
320389007494	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
320389007495	RNA binding site [nucleotide binding]; other site
320389007496	active site
320389007497	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
320389007498	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389007499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389007500	putative substrate translocation pore; other site
320389007501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389007502	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
320389007503	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389007504	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389007505	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
320389007506	Transcriptional regulators [Transcription]; Region: MarR; COG1846
320389007507	MarR family; Region: MarR_2; pfam12802
320389007508	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
320389007509	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
320389007510	G1 box; other site
320389007511	putative GEF interaction site [polypeptide binding]; other site
320389007512	GTP/Mg2+ binding site [chemical binding]; other site
320389007513	Switch I region; other site
320389007514	G2 box; other site
320389007515	G3 box; other site
320389007516	Switch II region; other site
320389007517	G4 box; other site
320389007518	G5 box; other site
320389007519	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
320389007520	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
320389007521	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
320389007522	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
320389007523	TPP-binding site [chemical binding]; other site
320389007524	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
320389007525	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
320389007526	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
320389007527	E3 interaction surface; other site
320389007528	lipoyl attachment site [posttranslational modification]; other site
320389007529	e3 binding domain; Region: E3_binding; pfam02817
320389007530	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
320389007531	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
320389007532	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389007533	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
320389007534	Predicted ATPase [General function prediction only]; Region: COG1485
320389007535	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389007536	Walker B; other site
320389007537	D-loop; other site
320389007538	H-loop/switch region; other site
320389007539	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
320389007540	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
320389007541	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
320389007542	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
320389007543	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
320389007544	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
320389007545	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
320389007546	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
320389007547	active site
320389007548	Transposase; Region: HTH_Tnp_1; pfam01527
320389007549	HTH-like domain; Region: HTH_21; pfam13276
320389007550	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389007551	Integrase core domain; Region: rve; pfam00665
320389007552	Integrase core domain; Region: rve_3; pfam13683
320389007553	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
320389007554	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
320389007555	Transcriptional regulators [Transcription]; Region: FadR; COG2186
320389007556	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389007557	DNA-binding site [nucleotide binding]; DNA binding site
320389007558	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
320389007559	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
320389007560	tetramer (dimer of dimers) interface [polypeptide binding]; other site
320389007561	active site
320389007562	dimer interface [polypeptide binding]; other site
320389007563	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
320389007564	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
320389007565	amidase catalytic site [active]
320389007566	Zn binding residues [ion binding]; other site
320389007567	substrate binding site [chemical binding]; other site
320389007568	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
320389007569	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
320389007570	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
320389007571	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
320389007572	ribonuclease R; Region: RNase_R; TIGR02063
320389007573	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
320389007574	RNB domain; Region: RNB; pfam00773
320389007575	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389007576	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
320389007577	RNA binding site [nucleotide binding]; other site
320389007578	Transposase domain (DUF772); Region: DUF772; pfam05598
320389007579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389007580	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389007581	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389007582	dimer interface [polypeptide binding]; other site
320389007583	putative CheW interface [polypeptide binding]; other site
320389007584	Phosphoesterase family; Region: Phosphoesterase; pfam04185
320389007585	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
320389007586	Sulfate transporter family; Region: Sulfate_transp; pfam00916
320389007587	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
320389007588	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
320389007589	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
320389007590	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
320389007591	putative sialic acid transporter; Region: 2A0112; TIGR00891
320389007592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389007593	putative substrate translocation pore; other site
320389007594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389007595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389007596	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
320389007597	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
320389007598	acyl-activating enzyme (AAE) consensus motif; other site
320389007599	putative AMP binding site [chemical binding]; other site
320389007600	putative active site [active]
320389007601	putative CoA binding site [chemical binding]; other site
320389007602	bacterial Hfq-like; Region: Hfq; cd01716
320389007603	hexamer interface [polypeptide binding]; other site
320389007604	Sm1 motif; other site
320389007605	RNA binding site [nucleotide binding]; other site
320389007606	Sm2 motif; other site
320389007607	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
320389007608	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
320389007609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389007610	Walker A motif; other site
320389007611	ATP binding site [chemical binding]; other site
320389007612	Walker B motif; other site
320389007613	arginine finger; other site
320389007614	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389007615	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
320389007616	Predicted membrane protein [Function unknown]; Region: COG4655
320389007617	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
320389007618	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
320389007619	TPR repeat; Region: TPR_11; pfam13414
320389007620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389007621	binding surface
320389007622	TPR motif; other site
320389007623	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
320389007624	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389007625	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
320389007626	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389007627	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
320389007628	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
320389007629	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
320389007630	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
320389007631	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389007632	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
320389007633	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
320389007634	TadE-like protein; Region: TadE; pfam07811
320389007635	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
320389007636	HTH-like domain; Region: HTH_21; pfam13276
320389007637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389007638	Integrase core domain; Region: rve; pfam00665
320389007639	Integrase core domain; Region: rve_3; pfam13683
320389007640	Transposase; Region: HTH_Tnp_1; pfam01527
320389007641	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
320389007642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389007643	dimer interface [polypeptide binding]; other site
320389007644	conserved gate region; other site
320389007645	putative PBP binding loops; other site
320389007646	ABC-ATPase subunit interface; other site
320389007647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389007648	dimer interface [polypeptide binding]; other site
320389007649	conserved gate region; other site
320389007650	putative PBP binding loops; other site
320389007651	ABC-ATPase subunit interface; other site
320389007652	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
320389007653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389007654	Walker A/P-loop; other site
320389007655	ATP binding site [chemical binding]; other site
320389007656	Q-loop/lid; other site
320389007657	ABC transporter signature motif; other site
320389007658	Walker B; other site
320389007659	D-loop; other site
320389007660	H-loop/switch region; other site
320389007661	TOBE domain; Region: TOBE_2; pfam08402
320389007662	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
320389007663	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
320389007664	Predicted Fe-S protein [General function prediction only]; Region: COG3313
320389007665	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
320389007666	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
320389007667	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
320389007668	FMN binding site [chemical binding]; other site
320389007669	substrate binding site [chemical binding]; other site
320389007670	putative catalytic residue [active]
320389007671	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
320389007672	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389007673	NAD binding site [chemical binding]; other site
320389007674	catalytic residues [active]
320389007675	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
320389007676	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389007677	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389007678	ABC transporter; Region: ABC_tran_2; pfam12848
320389007679	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389007680	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
320389007681	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
320389007682	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
320389007683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389007684	Walker A/P-loop; other site
320389007685	ATP binding site [chemical binding]; other site
320389007686	Q-loop/lid; other site
320389007687	ABC transporter signature motif; other site
320389007688	Walker B; other site
320389007689	D-loop; other site
320389007690	H-loop/switch region; other site
320389007691	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
320389007692	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
320389007693	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
320389007694	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389007695	motif II; other site
320389007696	cystathionine beta-lyase; Provisional; Region: PRK07050
320389007697	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389007698	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389007699	catalytic residue [active]
320389007700	beta-ketothiolase; Provisional; Region: PRK09051
320389007701	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389007702	dimer interface [polypeptide binding]; other site
320389007703	active site
320389007704	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
320389007705	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
320389007706	substrate binding site [chemical binding]; other site
320389007707	ATP binding site [chemical binding]; other site
320389007708	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
320389007709	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
320389007710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389007711	FeS/SAM binding site; other site
320389007712	TRAM domain; Region: TRAM; cl01282
320389007713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
320389007714	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
320389007715	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
320389007716	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
320389007717	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
320389007718	NAD(P) binding site [chemical binding]; other site
320389007719	homotetramer interface [polypeptide binding]; other site
320389007720	homodimer interface [polypeptide binding]; other site
320389007721	active site
320389007722	putative acyltransferase; Provisional; Region: PRK05790
320389007723	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389007724	dimer interface [polypeptide binding]; other site
320389007725	active site
320389007726	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
320389007727	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
320389007728	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
320389007729	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
320389007730	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
320389007731	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389007732	RNA binding surface [nucleotide binding]; other site
320389007733	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
320389007734	active site
320389007735	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
320389007736	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
320389007737	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
320389007738	DEAD_2; Region: DEAD_2; pfam06733
320389007739	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
320389007740	Protein of unknown function (DUF465); Region: DUF465; pfam04325
320389007741	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
320389007742	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
320389007743	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
320389007744	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
320389007745	RNA binding site [nucleotide binding]; other site
320389007746	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913
320389007747	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
320389007748	potassium uptake protein; Region: kup; TIGR00794
320389007749	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
320389007750	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389007751	active site
320389007752	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
320389007753	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
320389007754	GDP-binding site [chemical binding]; other site
320389007755	ACT binding site; other site
320389007756	IMP binding site; other site
320389007757	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
320389007758	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
320389007759	dimer interface [polypeptide binding]; other site
320389007760	motif 1; other site
320389007761	active site
320389007762	motif 2; other site
320389007763	motif 3; other site
320389007764	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
320389007765	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
320389007766	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
320389007767	HflK protein; Region: hflK; TIGR01933
320389007768	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
320389007769	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
320389007770	HflX GTPase family; Region: HflX; cd01878
320389007771	G1 box; other site
320389007772	GTP/Mg2+ binding site [chemical binding]; other site
320389007773	Switch I region; other site
320389007774	G2 box; other site
320389007775	G3 box; other site
320389007776	Switch II region; other site
320389007777	G4 box; other site
320389007778	G5 box; other site
320389007779	bacterial Hfq-like; Region: Hfq; cd01716
320389007780	hexamer interface [polypeptide binding]; other site
320389007781	Sm1 motif; other site
320389007782	RNA binding site [nucleotide binding]; other site
320389007783	Sm2 motif; other site
320389007784	GTP-binding protein Der; Reviewed; Region: PRK00093
320389007785	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
320389007786	G1 box; other site
320389007787	GTP/Mg2+ binding site [chemical binding]; other site
320389007788	Switch I region; other site
320389007789	G2 box; other site
320389007790	Switch II region; other site
320389007791	G3 box; other site
320389007792	G4 box; other site
320389007793	G5 box; other site
320389007794	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
320389007795	G1 box; other site
320389007796	GTP/Mg2+ binding site [chemical binding]; other site
320389007797	Switch I region; other site
320389007798	G2 box; other site
320389007799	G3 box; other site
320389007800	Switch II region; other site
320389007801	G4 box; other site
320389007802	G5 box; other site
320389007803	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
320389007804	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
320389007805	Trp docking motif [polypeptide binding]; other site
320389007806	active site
320389007807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
320389007808	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
320389007809	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
320389007810	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
320389007811	dimer interface [polypeptide binding]; other site
320389007812	motif 1; other site
320389007813	active site
320389007814	motif 2; other site
320389007815	motif 3; other site
320389007816	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
320389007817	anticodon binding site; other site
320389007818	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
320389007819	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
320389007820	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
320389007821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389007822	non-specific DNA binding site [nucleotide binding]; other site
320389007823	salt bridge; other site
320389007824	sequence-specific DNA binding site [nucleotide binding]; other site
320389007825	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
320389007826	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
320389007827	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389007828	FeS/SAM binding site; other site
320389007829	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
320389007830	active site
320389007831	multimer interface [polypeptide binding]; other site
320389007832	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
320389007833	YccA-like proteins; Region: YccA_like; cd10433
320389007834	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
320389007835	TRAM domain; Region: TRAM; cl01282
320389007836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389007837	S-adenosylmethionine binding site [chemical binding]; other site
320389007838	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
320389007839	putative catalytic site [active]
320389007840	putative metal binding site [ion binding]; other site
320389007841	putative phosphate binding site [ion binding]; other site
320389007842	putative catalytic site [active]
320389007843	putative phosphate binding site [ion binding]; other site
320389007844	putative metal binding site [ion binding]; other site
320389007845	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
320389007846	active site
320389007847	catalytic site [active]
320389007848	substrate binding site [chemical binding]; other site
320389007849	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
320389007850	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
320389007851	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
320389007852	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389007853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389007854	DNA binding residues [nucleotide binding]
320389007855	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
320389007856	Peptidase family M23; Region: Peptidase_M23; pfam01551
320389007857	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
320389007858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389007859	S-adenosylmethionine binding site [chemical binding]; other site
320389007860	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
320389007861	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
320389007862	CoA-transferase family III; Region: CoA_transf_3; pfam02515
320389007863	recombination protein RecR; Reviewed; Region: recR; PRK00076
320389007864	RecR protein; Region: RecR; pfam02132
320389007865	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
320389007866	putative active site [active]
320389007867	putative metal-binding site [ion binding]; other site
320389007868	tetramer interface [polypeptide binding]; other site
320389007869	hypothetical protein; Validated; Region: PRK00153
320389007870	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
320389007871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389007872	Walker A motif; other site
320389007873	ATP binding site [chemical binding]; other site
320389007874	Walker B motif; other site
320389007875	arginine finger; other site
320389007876	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
320389007877	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
320389007878	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389007879	catalytic residues [active]
320389007880	transcription termination factor Rho; Provisional; Region: rho; PRK09376
320389007881	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
320389007882	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
320389007883	RNA binding site [nucleotide binding]; other site
320389007884	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
320389007885	multimer interface [polypeptide binding]; other site
320389007886	Walker A motif; other site
320389007887	ATP binding site [chemical binding]; other site
320389007888	Walker B motif; other site
320389007889	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
320389007890	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
320389007891	DNA binding residues [nucleotide binding]
320389007892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389007893	putative substrate translocation pore; other site
320389007894	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389007895	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
320389007896	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
320389007897	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
320389007898	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
320389007899	putative efflux protein, MATE family; Region: matE; TIGR00797
320389007900	cation binding site [ion binding]; other site
320389007901	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
320389007902	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
320389007903	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
320389007904	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
320389007905	Clp amino terminal domain; Region: Clp_N; pfam02861
320389007906	Clp amino terminal domain; Region: Clp_N; pfam02861
320389007907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389007908	Walker A motif; other site
320389007909	ATP binding site [chemical binding]; other site
320389007910	Walker B motif; other site
320389007911	arginine finger; other site
320389007912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389007913	Walker A motif; other site
320389007914	ATP binding site [chemical binding]; other site
320389007915	Walker B motif; other site
320389007916	arginine finger; other site
320389007917	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
320389007918	Transcriptional regulator; Region: Rrf2; cl17282
320389007919	Rrf2 family protein; Region: rrf2_super; TIGR00738
320389007920	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
320389007921	apolar tunnel; other site
320389007922	heme binding site [chemical binding]; other site
320389007923	dimerization interface [polypeptide binding]; other site
320389007924	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
320389007925	MoaE homodimer interface [polypeptide binding]; other site
320389007926	MoaD interaction [polypeptide binding]; other site
320389007927	active site residues [active]
320389007928	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
320389007929	MoaE interaction surface [polypeptide binding]; other site
320389007930	MoeB interaction surface [polypeptide binding]; other site
320389007931	thiocarboxylated glycine; other site
320389007932	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
320389007933	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
320389007934	dimer interface [polypeptide binding]; other site
320389007935	putative functional site; other site
320389007936	putative MPT binding site; other site
320389007937	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
320389007938	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
320389007939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389007940	catalytic residue [active]
320389007941	homoserine dehydrogenase; Provisional; Region: PRK06349
320389007942	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
320389007943	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
320389007944	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
320389007945	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
320389007946	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
320389007947	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
320389007948	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
320389007949	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
320389007950	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
320389007951	inhibitor-cofactor binding pocket; inhibition site
320389007952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389007953	catalytic residue [active]
320389007954	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
320389007955	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
320389007956	Ligand binding site; other site
320389007957	Putative Catalytic site; other site
320389007958	DXD motif; other site
320389007959	putative formyltransferase; Provisional; Region: PRK06988
320389007960	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
320389007961	active site
320389007962	substrate binding site [chemical binding]; other site
320389007963	cosubstrate binding site; other site
320389007964	catalytic site [active]
320389007965	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
320389007966	active site
320389007967	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
320389007968	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
320389007969	NAD binding site [chemical binding]; other site
320389007970	substrate binding site [chemical binding]; other site
320389007971	active site
320389007972	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
320389007973	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
320389007974	putative active site [active]
320389007975	putative catalytic site [active]
320389007976	putative Zn binding site [ion binding]; other site
320389007977	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
320389007978	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389007979	catalytic triad [active]
320389007980	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
320389007981	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
320389007982	putative active site [active]
320389007983	PhoH-like protein; Region: PhoH; pfam02562
320389007984	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
320389007985	NlpC/P60 family; Region: NLPC_P60; pfam00877
320389007986	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
320389007987	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
320389007988	replicative DNA helicase; Provisional; Region: PRK07004
320389007989	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
320389007990	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
320389007991	Walker A motif; other site
320389007992	ATP binding site [chemical binding]; other site
320389007993	Walker B motif; other site
320389007994	DNA binding loops [nucleotide binding]
320389007995	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
320389007996	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
320389007997	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
320389007998	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
320389007999	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
320389008000	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
320389008001	Putative zinc-finger; Region: zf-HC2; pfam13490
320389008002	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
320389008003	RNA polymerase sigma factor; Provisional; Region: PRK12533
320389008004	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389008005	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389008006	DNA binding residues [nucleotide binding]
320389008007	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
320389008008	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389008009	active site
320389008010	metal binding site [ion binding]; metal-binding site
320389008011	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
320389008012	HTH-like domain; Region: HTH_21; pfam13276
320389008013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389008014	Integrase core domain; Region: rve; pfam00665
320389008015	Integrase core domain; Region: rve_3; pfam13683
320389008016	Transposase; Region: HTH_Tnp_1; pfam01527
320389008017	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
320389008018	active site
320389008019	homodimer interface [polypeptide binding]; other site
320389008020	homotetramer interface [polypeptide binding]; other site
320389008021	psiF repeat; Region: PsiF_repeat; pfam07769
320389008022	psiF repeat; Region: PsiF_repeat; pfam07769
320389008023	Domain of unknown function DUF221; Region: DUF221; pfam02714
320389008024	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
320389008025	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
320389008026	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389008027	putative ADP-binding pocket [chemical binding]; other site
320389008028	Predicted ATPase [General function prediction only]; Region: COG4637
320389008029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389008030	Walker A/P-loop; other site
320389008031	ATP binding site [chemical binding]; other site
320389008032	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
320389008033	Mechanosensitive ion channel; Region: MS_channel; pfam00924
320389008034	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
320389008035	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
320389008036	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
320389008037	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
320389008038	active site
320389008039	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
320389008040	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389008041	Coenzyme A binding pocket [chemical binding]; other site
320389008042	DNA polymerase III subunit delta'; Validated; Region: PRK06964
320389008043	DNA polymerase III subunit delta'; Validated; Region: PRK08485
320389008044	thymidylate kinase; Validated; Region: tmk; PRK00698
320389008045	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
320389008046	TMP-binding site; other site
320389008047	ATP-binding site [chemical binding]; other site
320389008048	YceG-like family; Region: YceG; pfam02618
320389008049	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
320389008050	dimerization interface [polypeptide binding]; other site
320389008051	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
320389008052	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
320389008053	NRDE protein; Region: NRDE; cl01315
320389008054	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
320389008055	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389008056	Coenzyme A binding pocket [chemical binding]; other site
320389008057	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
320389008058	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
320389008059	substrate binding pocket [chemical binding]; other site
320389008060	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
320389008061	Prostaglandin dehydrogenases; Region: PGDH; cd05288
320389008062	NAD(P) binding site [chemical binding]; other site
320389008063	substrate binding site [chemical binding]; other site
320389008064	dimer interface [polypeptide binding]; other site
320389008065	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
320389008066	CoenzymeA binding site [chemical binding]; other site
320389008067	subunit interaction site [polypeptide binding]; other site
320389008068	PHB binding site; other site
320389008069	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
320389008070	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389008071	dimer interface [polypeptide binding]; other site
320389008072	active site
320389008073	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
320389008074	catalytic triad [active]
320389008075	metal binding site [ion binding]; metal-binding site
320389008076	conserved cis-peptide bond; other site
320389008077	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389008078	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
320389008079	substrate binding site [chemical binding]; other site
320389008080	oxyanion hole (OAH) forming residues; other site
320389008081	trimer interface [polypeptide binding]; other site
320389008082	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
320389008083	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389008084	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389008085	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
320389008086	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
320389008087	dimer interface [polypeptide binding]; other site
320389008088	acyl-activating enzyme (AAE) consensus motif; other site
320389008089	putative active site [active]
320389008090	AMP binding site [chemical binding]; other site
320389008091	putative CoA binding site [chemical binding]; other site
320389008092	Uncharacterized conserved protein [Function unknown]; Region: COG0397
320389008093	hypothetical protein; Validated; Region: PRK00029
320389008094	SelR domain; Region: SelR; pfam01641
320389008095	methionine sulfoxide reductase B; Provisional; Region: PRK00222
320389008096	intracellular septation protein A; Reviewed; Region: PRK00259
320389008097	BolA-like protein; Region: BolA; pfam01722
320389008098	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
320389008099	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
320389008100	Predicted acetyltransferase [General function prediction only]; Region: COG3153
320389008101	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
320389008102	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
320389008103	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
320389008104	dimerization interface [polypeptide binding]; other site
320389008105	ATP binding site [chemical binding]; other site
320389008106	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
320389008107	dimerization interface [polypeptide binding]; other site
320389008108	ATP binding site [chemical binding]; other site
320389008109	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
320389008110	putative active site [active]
320389008111	catalytic triad [active]
320389008112	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
320389008113	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
320389008114	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
320389008115	putative substrate binding site [chemical binding]; other site
320389008116	putative ATP binding site [chemical binding]; other site
320389008117	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
320389008118	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
320389008119	active site
320389008120	dimer interface [polypeptide binding]; other site
320389008121	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
320389008122	dimer interface [polypeptide binding]; other site
320389008123	active site
320389008124	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
320389008125	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
320389008126	Walker A/P-loop; other site
320389008127	ATP binding site [chemical binding]; other site
320389008128	Q-loop/lid; other site
320389008129	ABC transporter signature motif; other site
320389008130	Walker B; other site
320389008131	D-loop; other site
320389008132	H-loop/switch region; other site
320389008133	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
320389008134	active site
320389008135	catalytic triad [active]
320389008136	oxyanion hole [active]
320389008137	switch loop; other site
320389008138	SurA N-terminal domain; Region: SurA_N_3; cl07813
320389008139	periplasmic folding chaperone; Provisional; Region: PRK10788
320389008140	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
320389008141	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
320389008142	Found in ATP-dependent protease La (LON); Region: LON; smart00464
320389008143	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389008144	Walker A motif; other site
320389008145	ATP binding site [chemical binding]; other site
320389008146	Walker B motif; other site
320389008147	arginine finger; other site
320389008148	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
320389008149	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
320389008150	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
320389008151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389008152	Walker A motif; other site
320389008153	ATP binding site [chemical binding]; other site
320389008154	Walker B motif; other site
320389008155	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
320389008156	Clp protease; Region: CLP_protease; pfam00574
320389008157	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
320389008158	oligomer interface [polypeptide binding]; other site
320389008159	active site residues [active]
320389008160	trigger factor; Provisional; Region: tig; PRK01490
320389008161	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
320389008162	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
320389008163	Glycerate kinase family; Region: Gly_kinase; cl00841
320389008164	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389008165	MarR family; Region: MarR_2; pfam12802
320389008166	MarR family; Region: MarR_2; cl17246
320389008167	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
320389008168	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
320389008169	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
320389008170	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389008171	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389008172	dimerization interface [polypeptide binding]; other site
320389008173	DNA binding residues [nucleotide binding]
320389008174	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389008175	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389008176	trimer interface [polypeptide binding]; other site
320389008177	eyelet of channel; other site
320389008178	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
320389008179	PLD-like domain; Region: PLDc_2; pfam13091
320389008180	putative active site [active]
320389008181	catalytic site [active]
320389008182	HTH-like domain; Region: HTH_21; pfam13276
320389008183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389008184	Integrase core domain; Region: rve; pfam00665
320389008185	Integrase core domain; Region: rve_3; pfam13683
320389008186	Transposase; Region: HTH_Tnp_1; pfam01527
320389008187	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
320389008188	active site lid residues [active]
320389008189	substrate binding pocket [chemical binding]; other site
320389008190	catalytic residues [active]
320389008191	substrate-Mg2+ binding site; other site
320389008192	aspartate-rich region 1; other site
320389008193	aspartate-rich region 2; other site
320389008194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
320389008195	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
320389008196	osmolarity response regulator; Provisional; Region: ompR; PRK09468
320389008197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389008198	active site
320389008199	phosphorylation site [posttranslational modification]
320389008200	intermolecular recognition site; other site
320389008201	dimerization interface [polypeptide binding]; other site
320389008202	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389008203	DNA binding site [nucleotide binding]
320389008204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389008205	HAMP domain; Region: HAMP; pfam00672
320389008206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389008207	dimer interface [polypeptide binding]; other site
320389008208	phosphorylation site [posttranslational modification]
320389008209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389008210	ATP binding site [chemical binding]; other site
320389008211	Mg2+ binding site [ion binding]; other site
320389008212	G-X-G motif; other site
320389008213	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
320389008214	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
320389008215	dimer interface [polypeptide binding]; other site
320389008216	decamer (pentamer of dimers) interface [polypeptide binding]; other site
320389008217	catalytic triad [active]
320389008218	peroxidatic and resolving cysteines [active]
320389008219	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
320389008220	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
320389008221	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
320389008222	homotrimer interaction site [polypeptide binding]; other site
320389008223	zinc binding site [ion binding]; other site
320389008224	CDP-binding sites; other site
320389008225	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
320389008226	substrate binding site; other site
320389008227	dimer interface; other site
320389008228	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
320389008229	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
320389008230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389008231	ATP binding site [chemical binding]; other site
320389008232	putative Mg++ binding site [ion binding]; other site
320389008233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389008234	nucleotide binding region [chemical binding]; other site
320389008235	ATP-binding site [chemical binding]; other site
320389008236	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
320389008237	acetylornithine deacetylase; Provisional; Region: PRK07522
320389008238	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
320389008239	metal binding site [ion binding]; metal-binding site
320389008240	putative dimer interface [polypeptide binding]; other site
320389008241	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
320389008242	tetramer interface [polypeptide binding]; other site
320389008243	hypothetical protein; Provisional; Region: PRK06815
320389008244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389008245	catalytic residue [active]
320389008246	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
320389008247	Transglycosylase; Region: Transgly; pfam00912
320389008248	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
320389008249	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
320389008250	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
320389008251	Tetratricopeptide repeat; Region: TPR_16; pfam13432
320389008252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389008253	TPR motif; other site
320389008254	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
320389008255	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
320389008256	Transposase domain (DUF772); Region: DUF772; pfam05598
320389008257	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389008258	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389008259	ureidoglycolate hydrolase; Provisional; Region: PRK03606
320389008260	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
320389008261	allantoicase; Provisional; Region: PRK13257
320389008262	Allantoicase repeat; Region: Allantoicase; pfam03561
320389008263	Allantoicase repeat; Region: Allantoicase; pfam03561
320389008264	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
320389008265	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
320389008266	active site
320389008267	catalytic site [active]
320389008268	tetramer interface [polypeptide binding]; other site
320389008269	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
320389008270	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
320389008271	Na binding site [ion binding]; other site
320389008272	putative substrate binding site [chemical binding]; other site
320389008273	Transcriptional regulators [Transcription]; Region: GntR; COG1802
320389008274	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389008275	DNA-binding site [nucleotide binding]; DNA binding site
320389008276	FCD domain; Region: FCD; pfam07729
320389008277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389008278	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389008279	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
320389008280	dimer interface [polypeptide binding]; other site
320389008281	catalytic triad [active]
320389008282	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
320389008283	nucleoside/Zn binding site; other site
320389008284	dimer interface [polypeptide binding]; other site
320389008285	catalytic motif [active]
320389008286	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
320389008287	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
320389008288	GMP synthase; Reviewed; Region: guaA; PRK00074
320389008289	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
320389008290	AMP/PPi binding site [chemical binding]; other site
320389008291	candidate oxyanion hole; other site
320389008292	catalytic triad [active]
320389008293	potential glutamine specificity residues [chemical binding]; other site
320389008294	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
320389008295	ATP Binding subdomain [chemical binding]; other site
320389008296	Ligand Binding sites [chemical binding]; other site
320389008297	Dimerization subdomain; other site
320389008298	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
320389008299	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
320389008300	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
320389008301	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
320389008302	active site
320389008303	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
320389008304	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
320389008305	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
320389008306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
320389008307	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
320389008308	putative coenzyme Q binding site [chemical binding]; other site
320389008309	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
320389008310	SmpB-tmRNA interface; other site
320389008311	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
320389008312	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
320389008313	phosphoenolpyruvate synthase; Validated; Region: PRK06464
320389008314	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
320389008315	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
320389008316	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
320389008317	Phytochelatin synthase; Region: Phytochelatin; pfam05023
320389008318	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
320389008319	peptidase domain interface [polypeptide binding]; other site
320389008320	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
320389008321	active site
320389008322	catalytic triad [active]
320389008323	calcium binding site [ion binding]; other site
320389008324	PEP synthetase regulatory protein; Provisional; Region: PRK05339
320389008325	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
320389008326	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
320389008327	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
320389008328	RNA/DNA hybrid binding site [nucleotide binding]; other site
320389008329	active site
320389008330	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
320389008331	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
320389008332	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
320389008333	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
320389008334	active site
320389008335	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
320389008336	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
320389008337	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
320389008338	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
320389008339	trimer interface [polypeptide binding]; other site
320389008340	active site
320389008341	UDP-GlcNAc binding site [chemical binding]; other site
320389008342	lipid binding site [chemical binding]; lipid-binding site
320389008343	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
320389008344	periplasmic chaperone; Provisional; Region: PRK10780
320389008345	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
320389008346	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
320389008347	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
320389008348	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
320389008349	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
320389008350	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
320389008351	Surface antigen; Region: Bac_surface_Ag; pfam01103
320389008352	zinc metallopeptidase RseP; Provisional; Region: PRK10779
320389008353	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
320389008354	active site
320389008355	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
320389008356	protein binding site [polypeptide binding]; other site
320389008357	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
320389008358	putative substrate binding region [chemical binding]; other site
320389008359	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
320389008360	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464
320389008361	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
320389008362	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
320389008363	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
320389008364	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
320389008365	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
320389008366	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
320389008367	catalytic residue [active]
320389008368	putative FPP diphosphate  binding site; other site
320389008369	putative FPP binding hydrophobic cleft; other site
320389008370	dimer interface [polypeptide binding]; other site
320389008371	putative IPP diphosphate binding site; other site
320389008372	ribosome recycling factor; Reviewed; Region: frr; PRK00083
320389008373	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
320389008374	hinge region; other site
320389008375	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
320389008376	putative nucleotide binding site [chemical binding]; other site
320389008377	uridine monophosphate binding site [chemical binding]; other site
320389008378	homohexameric interface [polypeptide binding]; other site
320389008379	elongation factor Ts; Provisional; Region: tsf; PRK09377
320389008380	UBA/TS-N domain; Region: UBA; pfam00627
320389008381	Elongation factor TS; Region: EF_TS; pfam00889
320389008382	Elongation factor TS; Region: EF_TS; pfam00889
320389008383	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
320389008384	rRNA interaction site [nucleotide binding]; other site
320389008385	S8 interaction site; other site
320389008386	putative laminin-1 binding site; other site
320389008387	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
320389008388	active site
320389008389	PII uridylyl-transferase; Provisional; Region: PRK03059
320389008390	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
320389008391	metal binding triad; other site
320389008392	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
320389008393	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
320389008394	Zn2+ binding site [ion binding]; other site
320389008395	Mg2+ binding site [ion binding]; other site
320389008396	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
320389008397	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
320389008398	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
320389008399	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389008400	RNA binding surface [nucleotide binding]; other site
320389008401	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
320389008402	active site
320389008403	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
320389008404	active site
320389008405	catalytic residues [active]
320389008406	metal binding site [ion binding]; metal-binding site
320389008407	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
320389008408	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
320389008409	nucleotide binding pocket [chemical binding]; other site
320389008410	K-X-D-G motif; other site
320389008411	catalytic site [active]
320389008412	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
320389008413	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
320389008414	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
320389008415	Dimer interface [polypeptide binding]; other site
320389008416	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
320389008417	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
320389008418	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
320389008419	Walker A/P-loop; other site
320389008420	ATP binding site [chemical binding]; other site
320389008421	Q-loop/lid; other site
320389008422	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
320389008423	Q-loop/lid; other site
320389008424	ABC transporter signature motif; other site
320389008425	Walker B; other site
320389008426	D-loop; other site
320389008427	H-loop/switch region; other site
320389008428	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
320389008429	EamA-like transporter family; Region: EamA; pfam00892
320389008430	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
320389008431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389008432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389008433	homodimer interface [polypeptide binding]; other site
320389008434	catalytic residue [active]
320389008435	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
320389008436	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
320389008437	trimer interface [polypeptide binding]; other site
320389008438	active site
320389008439	substrate binding site [chemical binding]; other site
320389008440	CoA binding site [chemical binding]; other site
320389008441	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
320389008442	ArsC family; Region: ArsC; pfam03960
320389008443	putative catalytic residues [active]
320389008444	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
320389008445	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
320389008446	metal binding site [ion binding]; metal-binding site
320389008447	dimer interface [polypeptide binding]; other site
320389008448	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
320389008449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389008450	S-adenosylmethionine binding site [chemical binding]; other site
320389008451	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
320389008452	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
320389008453	putative active site [active]
320389008454	catalytic site [active]
320389008455	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
320389008456	putative active site [active]
320389008457	catalytic site [active]
320389008458	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
320389008459	catalytic residues [active]
320389008460	dimer interface [polypeptide binding]; other site
320389008461	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
320389008462	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389008463	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389008464	ABC transporter; Region: ABC_tran_2; pfam12848
320389008465	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389008466	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
320389008467	DNA repair protein RadA; Provisional; Region: PRK11823
320389008468	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
320389008469	Walker A motif/ATP binding site; other site
320389008470	ATP binding site [chemical binding]; other site
320389008471	Walker B motif; other site
320389008472	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
320389008473	alanine racemase; Reviewed; Region: dadX; PRK03646
320389008474	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
320389008475	active site
320389008476	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389008477	substrate binding site [chemical binding]; other site
320389008478	catalytic residues [active]
320389008479	dimer interface [polypeptide binding]; other site
320389008480	lysophospholipid transporter LplT; Provisional; Region: PRK11195
320389008481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389008482	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
320389008483	dimer interface [polypeptide binding]; other site
320389008484	substrate binding site [chemical binding]; other site
320389008485	ATP binding site [chemical binding]; other site
320389008486	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
320389008487	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
320389008488	Fe-S cluster binding site [ion binding]; other site
320389008489	active site
320389008490	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
320389008491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389008492	Coenzyme A binding pocket [chemical binding]; other site
320389008493	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
320389008494	Glycoprotease family; Region: Peptidase_M22; pfam00814
320389008495	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
320389008496	acyl-CoA binding pocket [chemical binding]; other site
320389008497	CoA binding site [chemical binding]; other site
320389008498	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
320389008499	DEAD-like helicases superfamily; Region: DEXDc; smart00487
320389008500	ATP binding site [chemical binding]; other site
320389008501	Mg++ binding site [ion binding]; other site
320389008502	motif III; other site
320389008503	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389008504	nucleotide binding region [chemical binding]; other site
320389008505	ATP-binding site [chemical binding]; other site
320389008506	Transposase domain (DUF772); Region: DUF772; pfam05598
320389008507	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389008508	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389008509	isocitrate lyase; Provisional; Region: PRK15063
320389008510	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
320389008511	tetramer interface [polypeptide binding]; other site
320389008512	active site
320389008513	Mg2+/Mn2+ binding site [ion binding]; other site
320389008514	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
320389008515	Ligand Binding Site [chemical binding]; other site
320389008516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389008517	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389008518	putative effector binding pocket; other site
320389008519	dimerization interface [polypeptide binding]; other site
320389008520	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
320389008521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389008522	motif II; other site
320389008523	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
320389008524	putative active site pocket [active]
320389008525	dimerization interface [polypeptide binding]; other site
320389008526	putative catalytic residue [active]
320389008527	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
320389008528	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
320389008529	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
320389008530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389008531	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389008532	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389008533	Coenzyme A binding pocket [chemical binding]; other site
320389008534	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
320389008535	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
320389008536	active site
320389008537	HIGH motif; other site
320389008538	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
320389008539	active site
320389008540	KMSKS motif; other site
320389008541	hypothetical protein; Provisional; Region: PRK10279
320389008542	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
320389008543	nucleophile elbow; other site
320389008544	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
320389008545	NlpC/P60 family; Region: NLPC_P60; pfam00877
320389008546	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
320389008547	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389008548	Walker A/P-loop; other site
320389008549	ATP binding site [chemical binding]; other site
320389008550	Q-loop/lid; other site
320389008551	ABC transporter signature motif; other site
320389008552	Walker B; other site
320389008553	D-loop; other site
320389008554	H-loop/switch region; other site
320389008555	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389008556	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389008557	Walker A/P-loop; other site
320389008558	ATP binding site [chemical binding]; other site
320389008559	Q-loop/lid; other site
320389008560	ABC transporter signature motif; other site
320389008561	Walker B; other site
320389008562	D-loop; other site
320389008563	H-loop/switch region; other site
320389008564	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389008565	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
320389008566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389008567	dimer interface [polypeptide binding]; other site
320389008568	conserved gate region; other site
320389008569	putative PBP binding loops; other site
320389008570	ABC-ATPase subunit interface; other site
320389008571	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
320389008572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389008573	dimer interface [polypeptide binding]; other site
320389008574	conserved gate region; other site
320389008575	putative PBP binding loops; other site
320389008576	ABC-ATPase subunit interface; other site
320389008577	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
320389008578	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
320389008579	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
320389008580	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
320389008581	NAD binding site [chemical binding]; other site
320389008582	homotetramer interface [polypeptide binding]; other site
320389008583	homodimer interface [polypeptide binding]; other site
320389008584	substrate binding site [chemical binding]; other site
320389008585	active site
320389008586	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
320389008587	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
320389008588	putative [Fe4-S4] binding site [ion binding]; other site
320389008589	putative molybdopterin cofactor binding site [chemical binding]; other site
320389008590	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
320389008591	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
320389008592	putative molybdopterin cofactor binding site; other site
320389008593	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
320389008594	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
320389008595	FAD binding pocket [chemical binding]; other site
320389008596	FAD binding motif [chemical binding]; other site
320389008597	phosphate binding motif [ion binding]; other site
320389008598	beta-alpha-beta structure motif; other site
320389008599	NAD binding pocket [chemical binding]; other site
320389008600	Ferredoxin [Energy production and conversion]; Region: COG1146
320389008601	4Fe-4S binding domain; Region: Fer4; cl02805
320389008602	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
320389008603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389008604	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
320389008605	active site
320389008606	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
320389008607	argininosuccinate lyase; Provisional; Region: PRK02186
320389008608	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
320389008609	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
320389008610	active sites [active]
320389008611	tetramer interface [polypeptide binding]; other site
320389008612	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
320389008613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389008614	catalytic residue [active]
320389008615	dimer interface [polypeptide binding]; other site
320389008616	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
320389008617	G1 box; other site
320389008618	GTP/Mg2+ binding site [chemical binding]; other site
320389008619	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
320389008620	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
320389008621	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
320389008622	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
320389008623	Active Sites [active]
320389008624	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
320389008625	active site
320389008626	phosphoserine aminotransferase; Provisional; Region: PRK12462
320389008627	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389008628	catalytic residue [active]
320389008629	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
320389008630	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
320389008631	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
320389008632	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
320389008633	PYR/PP interface [polypeptide binding]; other site
320389008634	dimer interface [polypeptide binding]; other site
320389008635	TPP binding site [chemical binding]; other site
320389008636	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
320389008637	TPP-binding site [chemical binding]; other site
320389008638	dimer interface [polypeptide binding]; other site
320389008639	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
320389008640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389008641	S-adenosylmethionine binding site [chemical binding]; other site
320389008642	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
320389008643	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
320389008644	active site
320389008645	iron coordination sites [ion binding]; other site
320389008646	substrate binding pocket [chemical binding]; other site
320389008647	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
320389008648	Condensation domain; Region: Condensation; pfam00668
320389008649	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
320389008650	Condensation domain; Region: Condensation; pfam00668
320389008651	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389008652	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
320389008653	acyl-activating enzyme (AAE) consensus motif; other site
320389008654	AMP binding site [chemical binding]; other site
320389008655	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389008656	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
320389008657	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
320389008658	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
320389008659	Transmembrane secretion effector; Region: MFS_3; pfam05977
320389008660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389008661	putative substrate translocation pore; other site
320389008662	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
320389008663	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
320389008664	acyl-activating enzyme (AAE) consensus motif; other site
320389008665	AMP binding site [chemical binding]; other site
320389008666	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
320389008667	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
320389008668	ligand-binding site [chemical binding]; other site
320389008669	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
320389008670	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389008671	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389008672	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
320389008673	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
320389008674	active site
320389008675	catalytic triad [active]
320389008676	oxyanion hole [active]
320389008677	Autotransporter beta-domain; Region: Autotransporter; smart00869
320389008678	aspartate kinase; Reviewed; Region: PRK06635
320389008679	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
320389008680	putative nucleotide binding site [chemical binding]; other site
320389008681	putative catalytic residues [active]
320389008682	putative Mg ion binding site [ion binding]; other site
320389008683	putative aspartate binding site [chemical binding]; other site
320389008684	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
320389008685	putative allosteric regulatory site; other site
320389008686	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
320389008687	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
320389008688	Ligand Binding Site [chemical binding]; other site
320389008689	TilS substrate binding domain; Region: TilS; pfam09179
320389008690	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
320389008691	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
320389008692	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
320389008693	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
320389008694	endonuclease III; Region: ENDO3c; smart00478
320389008695	minor groove reading motif; other site
320389008696	helix-hairpin-helix signature motif; other site
320389008697	substrate binding pocket [chemical binding]; other site
320389008698	active site
320389008699	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
320389008700	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
320389008701	active site
320389008702	HIGH motif; other site
320389008703	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
320389008704	KMSKS motif; other site
320389008705	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
320389008706	tRNA binding surface [nucleotide binding]; other site
320389008707	anticodon binding site; other site
320389008708	TPR repeat; Region: TPR_11; pfam13414
320389008709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389008710	binding surface
320389008711	TPR motif; other site
320389008712	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
320389008713	substrate binding site [chemical binding]; other site
320389008714	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
320389008715	substrate binding site [chemical binding]; other site
320389008716	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
320389008717	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
320389008718	putative active site [active]
320389008719	putative metal binding site [ion binding]; other site
320389008720	serine O-acetyltransferase; Region: cysE; TIGR01172
320389008721	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
320389008722	trimer interface [polypeptide binding]; other site
320389008723	active site
320389008724	substrate binding site [chemical binding]; other site
320389008725	CoA binding site [chemical binding]; other site
320389008726	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
320389008727	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
320389008728	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
320389008729	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
320389008730	active site
320389008731	dimerization interface [polypeptide binding]; other site
320389008732	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
320389008733	MutS domain I; Region: MutS_I; pfam01624
320389008734	MutS domain II; Region: MutS_II; pfam05188
320389008735	MutS domain III; Region: MutS_III; pfam05192
320389008736	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
320389008737	Walker A/P-loop; other site
320389008738	ATP binding site [chemical binding]; other site
320389008739	Q-loop/lid; other site
320389008740	ABC transporter signature motif; other site
320389008741	Walker B; other site
320389008742	D-loop; other site
320389008743	H-loop/switch region; other site
320389008744	Uncharacterized conserved protein [Function unknown]; Region: COG2850
320389008745	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
320389008746	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
320389008747	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
320389008748	dihydrodipicolinate synthase; Region: dapA; TIGR00674
320389008749	dimer interface [polypeptide binding]; other site
320389008750	active site
320389008751	catalytic residue [active]
320389008752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
320389008753	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
320389008754	active site
320389008755	HIGH motif; other site
320389008756	dimer interface [polypeptide binding]; other site
320389008757	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
320389008758	active site
320389008759	KMSKS motif; other site
320389008760	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
320389008761	Peptidase family M50; Region: Peptidase_M50; pfam02163
320389008762	active site
320389008763	putative substrate binding region [chemical binding]; other site
320389008764	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
320389008765	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
320389008766	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
320389008767	active site
320389008768	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
320389008769	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389008770	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
320389008771	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
320389008772	catalytic site [active]
320389008773	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
320389008774	dinuclear metal binding motif [ion binding]; other site
320389008775	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
320389008776	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
320389008777	trimer interface [polypeptide binding]; other site
320389008778	putative metal binding site [ion binding]; other site
320389008779	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
320389008780	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
320389008781	dimerization interface [polypeptide binding]; other site
320389008782	domain crossover interface; other site
320389008783	redox-dependent activation switch; other site
320389008784	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
320389008785	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
320389008786	enolase; Provisional; Region: eno; PRK00077
320389008787	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
320389008788	dimer interface [polypeptide binding]; other site
320389008789	metal binding site [ion binding]; metal-binding site
320389008790	substrate binding pocket [chemical binding]; other site
320389008791	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
320389008792	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
320389008793	CTP synthetase; Validated; Region: pyrG; PRK05380
320389008794	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
320389008795	Catalytic site [active]
320389008796	active site
320389008797	UTP binding site [chemical binding]; other site
320389008798	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
320389008799	active site
320389008800	putative oxyanion hole; other site
320389008801	catalytic triad [active]
320389008802	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389008803	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
320389008804	nucleophilic elbow; other site
320389008805	catalytic triad; other site
320389008806	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
320389008807	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
320389008808	Competence protein; Region: Competence; pfam03772
320389008809	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
320389008810	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
320389008811	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
320389008812	active site
320389008813	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
320389008814	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
320389008815	Walker A/P-loop; other site
320389008816	ATP binding site [chemical binding]; other site
320389008817	Q-loop/lid; other site
320389008818	ABC transporter signature motif; other site
320389008819	Walker B; other site
320389008820	D-loop; other site
320389008821	H-loop/switch region; other site
320389008822	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
320389008823	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
320389008824	FtsX-like permease family; Region: FtsX; pfam02687
320389008825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
320389008826	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
320389008827	DHH family; Region: DHH; pfam01368
320389008828	DHHA1 domain; Region: DHHA1; pfam02272
320389008829	This domain is found in peptide chain release factors; Region: PCRF; smart00937
320389008830	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
320389008831	RF-1 domain; Region: RF-1; pfam00472
320389008832	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
320389008833	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
320389008834	dimer interface [polypeptide binding]; other site
320389008835	putative anticodon binding site; other site
320389008836	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
320389008837	motif 1; other site
320389008838	active site
320389008839	motif 2; other site
320389008840	motif 3; other site
320389008841	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
320389008842	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
320389008843	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389008844	catalytic loop [active]
320389008845	iron binding site [ion binding]; other site
320389008846	chaperone protein HscA; Provisional; Region: hscA; PRK05183
320389008847	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
320389008848	nucleotide binding site [chemical binding]; other site
320389008849	putative NEF/HSP70 interaction site [polypeptide binding]; other site
320389008850	SBD interface [polypeptide binding]; other site
320389008851	co-chaperone HscB; Provisional; Region: hscB; PRK03578
320389008852	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
320389008853	HSP70 interaction site [polypeptide binding]; other site
320389008854	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
320389008855	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
320389008856	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
320389008857	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
320389008858	trimerization site [polypeptide binding]; other site
320389008859	active site
320389008860	cysteine desulfurase; Provisional; Region: PRK14012
320389008861	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
320389008862	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389008863	catalytic residue [active]
320389008864	Predicted transcriptional regulator [Transcription]; Region: COG1959
320389008865	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
320389008866	Low molecular weight phosphatase family; Region: LMWPc; cd00115
320389008867	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
320389008868	active site
320389008869	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
320389008870	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
320389008871	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
320389008872	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
320389008873	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
320389008874	Cysteine-rich domain; Region: CCG; pfam02754
320389008875	Cysteine-rich domain; Region: CCG; pfam02754
320389008876	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389008877	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389008878	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389008879	Transposase domain (DUF772); Region: DUF772; pfam05598
320389008880	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389008881	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389008882	Phasin protein; Region: Phasin_2; pfam09361
320389008883	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
320389008884	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
320389008885	Transposase domain (DUF772); Region: DUF772; pfam05598
320389008886	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389008887	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389008888	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
320389008889	E3 interaction surface; other site
320389008890	lipoyl attachment site [posttranslational modification]; other site
320389008891	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
320389008892	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389008893	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389008894	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
320389008895	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
320389008896	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
320389008897	E3 interaction surface; other site
320389008898	lipoyl attachment site [posttranslational modification]; other site
320389008899	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
320389008900	E3 interaction surface; other site
320389008901	lipoyl attachment site [posttranslational modification]; other site
320389008902	e3 binding domain; Region: E3_binding; pfam02817
320389008903	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
320389008904	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
320389008905	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
320389008906	dimer interface [polypeptide binding]; other site
320389008907	TPP-binding site [chemical binding]; other site
320389008908	PAS domain S-box; Region: sensory_box; TIGR00229
320389008909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389008910	putative active site [active]
320389008911	heme pocket [chemical binding]; other site
320389008912	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389008913	dimer interface [polypeptide binding]; other site
320389008914	phosphorylation site [posttranslational modification]
320389008915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389008916	ATP binding site [chemical binding]; other site
320389008917	Mg2+ binding site [ion binding]; other site
320389008918	G-X-G motif; other site
320389008919	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
320389008920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389008921	active site
320389008922	phosphorylation site [posttranslational modification]
320389008923	intermolecular recognition site; other site
320389008924	dimerization interface [polypeptide binding]; other site
320389008925	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389008926	DNA binding residues [nucleotide binding]
320389008927	dimerization interface [polypeptide binding]; other site
320389008928	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
320389008929	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
320389008930	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
320389008931	homodimer interface [polypeptide binding]; other site
320389008932	NADP binding site [chemical binding]; other site
320389008933	substrate binding site [chemical binding]; other site
320389008934	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
320389008935	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
320389008936	active site
320389008937	Zn binding site [ion binding]; other site
320389008938	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
320389008939	active site
320389008940	DNA polymerase IV; Validated; Region: PRK02406
320389008941	DNA binding site [nucleotide binding]
320389008942	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
320389008943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389008944	putative substrate translocation pore; other site
320389008945	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
320389008946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389008947	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
320389008948	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
320389008949	[4Fe-4S] binding site [ion binding]; other site
320389008950	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
320389008951	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
320389008952	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
320389008953	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
320389008954	molybdopterin cofactor binding site; other site
320389008955	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
320389008956	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
320389008957	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
320389008958	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
320389008959	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
320389008960	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389008961	dimerization interface [polypeptide binding]; other site
320389008962	GAF domain; Region: GAF; pfam01590
320389008963	Histidine kinase; Region: HisKA_3; pfam07730
320389008964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389008965	ATP binding site [chemical binding]; other site
320389008966	Mg2+ binding site [ion binding]; other site
320389008967	G-X-G motif; other site
320389008968	transcriptional regulator NarL; Provisional; Region: PRK10651
320389008969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389008970	active site
320389008971	phosphorylation site [posttranslational modification]
320389008972	intermolecular recognition site; other site
320389008973	dimerization interface [polypeptide binding]; other site
320389008974	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389008975	DNA binding residues [nucleotide binding]
320389008976	dimerization interface [polypeptide binding]; other site
320389008977	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
320389008978	putative catalytic site [active]
320389008979	putative phosphate binding site [ion binding]; other site
320389008980	active site
320389008981	metal binding site A [ion binding]; metal-binding site
320389008982	DNA binding site [nucleotide binding]
320389008983	putative AP binding site [nucleotide binding]; other site
320389008984	putative metal binding site B [ion binding]; other site
320389008985	Transposase domain (DUF772); Region: DUF772; pfam05598
320389008986	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389008987	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389008988	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
320389008989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389008990	active site
320389008991	phosphorylation site [posttranslational modification]
320389008992	intermolecular recognition site; other site
320389008993	dimerization interface [polypeptide binding]; other site
320389008994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389008995	Walker A motif; other site
320389008996	ATP binding site [chemical binding]; other site
320389008997	Walker B motif; other site
320389008998	arginine finger; other site
320389008999	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389009000	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
320389009001	PAS domain; Region: PAS; smart00091
320389009002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389009003	dimer interface [polypeptide binding]; other site
320389009004	phosphorylation site [posttranslational modification]
320389009005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389009006	ATP binding site [chemical binding]; other site
320389009007	Mg2+ binding site [ion binding]; other site
320389009008	G-X-G motif; other site
320389009009	glutamine synthetase; Provisional; Region: glnA; PRK09469
320389009010	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
320389009011	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
320389009012	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
320389009013	active site residue [active]
320389009014	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
320389009015	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
320389009016	putative MPT binding site; other site
320389009017	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
320389009018	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
320389009019	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
320389009020	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
320389009021	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
320389009022	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
320389009023	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389009024	ATP binding site [chemical binding]; other site
320389009025	putative Mg++ binding site [ion binding]; other site
320389009026	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389009027	nucleotide binding region [chemical binding]; other site
320389009028	ATP-binding site [chemical binding]; other site
320389009029	Helicase associated domain (HA2); Region: HA2; pfam04408
320389009030	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
320389009031	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
320389009032	N-acetylglutamate synthase; Validated; Region: PRK05279
320389009033	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
320389009034	putative feedback inhibition sensing region; other site
320389009035	putative nucleotide binding site [chemical binding]; other site
320389009036	putative substrate binding site [chemical binding]; other site
320389009037	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389009038	Coenzyme A binding pocket [chemical binding]; other site
320389009039	oxidative damage protection protein; Provisional; Region: PRK05408
320389009040	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009041	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389009042	putative substrate translocation pore; other site
320389009043	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
320389009044	CoA-transferase family III; Region: CoA_transf_3; pfam02515
320389009045	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389009046	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389009047	active site
320389009048	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
320389009049	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389009050	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389009051	dimerization interface [polypeptide binding]; other site
320389009052	HTH-like domain; Region: HTH_21; pfam13276
320389009053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009054	Integrase core domain; Region: rve; pfam00665
320389009055	Integrase core domain; Region: rve_3; pfam13683
320389009056	Transposase; Region: HTH_Tnp_1; pfam01527
320389009057	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
320389009058	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
320389009059	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
320389009060	ecotin; Provisional; Region: PRK03719
320389009061	secondary substrate binding site; other site
320389009062	primary substrate binding site; other site
320389009063	inhibition loop; other site
320389009064	dimerization interface [polypeptide binding]; other site
320389009065	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
320389009066	substrate binding site [chemical binding]; other site
320389009067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009068	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389009069	putative substrate translocation pore; other site
320389009070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
320389009071	Predicted ATPase [General function prediction only]; Region: COG3911
320389009072	AAA domain; Region: AAA_28; pfam13521
320389009073	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
320389009074	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
320389009075	active site
320389009076	homotetramer interface [polypeptide binding]; other site
320389009077	Transposase; Region: HTH_Tnp_1; pfam01527
320389009078	HTH-like domain; Region: HTH_21; pfam13276
320389009079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009080	Integrase core domain; Region: rve; pfam00665
320389009081	Integrase core domain; Region: rve_3; pfam13683
320389009082	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
320389009083	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
320389009084	Walker A/P-loop; other site
320389009085	ATP binding site [chemical binding]; other site
320389009086	Q-loop/lid; other site
320389009087	ABC transporter signature motif; other site
320389009088	Walker B; other site
320389009089	D-loop; other site
320389009090	H-loop/switch region; other site
320389009091	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
320389009092	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
320389009093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389009094	dimer interface [polypeptide binding]; other site
320389009095	conserved gate region; other site
320389009096	putative PBP binding loops; other site
320389009097	ABC-ATPase subunit interface; other site
320389009098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389009099	dimer interface [polypeptide binding]; other site
320389009100	conserved gate region; other site
320389009101	putative PBP binding loops; other site
320389009102	ABC-ATPase subunit interface; other site
320389009103	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
320389009104	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389009105	dimer interface [polypeptide binding]; other site
320389009106	phosphorylation site [posttranslational modification]
320389009107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389009108	ATP binding site [chemical binding]; other site
320389009109	Mg2+ binding site [ion binding]; other site
320389009110	G-X-G motif; other site
320389009111	osmolarity response regulator; Provisional; Region: ompR; PRK09468
320389009112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389009113	active site
320389009114	phosphorylation site [posttranslational modification]
320389009115	intermolecular recognition site; other site
320389009116	dimerization interface [polypeptide binding]; other site
320389009117	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389009118	DNA binding site [nucleotide binding]
320389009119	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
320389009120	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389009121	substrate binding pocket [chemical binding]; other site
320389009122	membrane-bound complex binding site; other site
320389009123	hinge residues; other site
320389009124	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389009125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389009126	dimer interface [polypeptide binding]; other site
320389009127	conserved gate region; other site
320389009128	putative PBP binding loops; other site
320389009129	ABC-ATPase subunit interface; other site
320389009130	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389009131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389009132	dimer interface [polypeptide binding]; other site
320389009133	conserved gate region; other site
320389009134	putative PBP binding loops; other site
320389009135	ABC-ATPase subunit interface; other site
320389009136	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
320389009137	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389009138	Walker A/P-loop; other site
320389009139	ATP binding site [chemical binding]; other site
320389009140	Q-loop/lid; other site
320389009141	ABC transporter signature motif; other site
320389009142	Walker B; other site
320389009143	D-loop; other site
320389009144	H-loop/switch region; other site
320389009145	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389009146	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389009147	trimer interface [polypeptide binding]; other site
320389009148	eyelet of channel; other site
320389009149	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
320389009150	Nitrogen regulatory protein P-II; Region: P-II; smart00938
320389009151	NAD synthetase; Provisional; Region: PRK13981
320389009152	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
320389009153	multimer interface [polypeptide binding]; other site
320389009154	active site
320389009155	catalytic triad [active]
320389009156	protein interface 1 [polypeptide binding]; other site
320389009157	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
320389009158	homodimer interface [polypeptide binding]; other site
320389009159	NAD binding pocket [chemical binding]; other site
320389009160	ATP binding pocket [chemical binding]; other site
320389009161	Mg binding site [ion binding]; other site
320389009162	active-site loop [active]
320389009163	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
320389009164	Protein of unknown function, DUF482; Region: DUF482; pfam04339
320389009165	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
320389009166	GIY-YIG motif/motif A; other site
320389009167	putative active site [active]
320389009168	putative metal binding site [ion binding]; other site
320389009169	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
320389009170	dimer interface [polypeptide binding]; other site
320389009171	substrate binding site [chemical binding]; other site
320389009172	metal binding sites [ion binding]; metal-binding site
320389009173	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389009174	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
320389009175	NAD(P) binding site [chemical binding]; other site
320389009176	catalytic residues [active]
320389009177	catalytic residues [active]
320389009178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389009179	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
320389009180	NAD(P) binding site [chemical binding]; other site
320389009181	active site
320389009182	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
320389009183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009184	putative substrate translocation pore; other site
320389009185	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
320389009186	HemY protein N-terminus; Region: HemY_N; pfam07219
320389009187	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
320389009188	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
320389009189	active site
320389009190	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
320389009191	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
320389009192	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
320389009193	domain interfaces; other site
320389009194	active site
320389009195	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
320389009196	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
320389009197	Transposase domain (DUF772); Region: DUF772; pfam05598
320389009198	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389009199	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389009200	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389009201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389009202	S-adenosylmethionine binding site [chemical binding]; other site
320389009203	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389009204	sequence-specific DNA binding site [nucleotide binding]; other site
320389009205	salt bridge; other site
320389009206	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389009207	Spore Coat Protein U domain; Region: SCPU; pfam05229
320389009208	Uncharacterized secreted protein [Function unknown]; Region: COG5430
320389009209	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
320389009210	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
320389009211	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
320389009212	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
320389009213	PapC C-terminal domain; Region: PapC_C; pfam13953
320389009214	argininosuccinate lyase; Provisional; Region: PRK00855
320389009215	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
320389009216	active sites [active]
320389009217	tetramer interface [polypeptide binding]; other site
320389009218	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
320389009219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389009220	motif II; other site
320389009221	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
320389009222	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
320389009223	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
320389009224	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
320389009225	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389009226	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389009227	catalytic residue [active]
320389009228	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
320389009229	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
320389009230	trimer interface [polypeptide binding]; other site
320389009231	active site
320389009232	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
320389009233	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
320389009234	E-class dimer interface [polypeptide binding]; other site
320389009235	P-class dimer interface [polypeptide binding]; other site
320389009236	active site
320389009237	Cu2+ binding site [ion binding]; other site
320389009238	Zn2+ binding site [ion binding]; other site
320389009239	Domain of unknown function DUF59; Region: DUF59; pfam01883
320389009240	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
320389009241	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
320389009242	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389009243	ligand binding site [chemical binding]; other site
320389009244	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
320389009245	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
320389009246	active site
320389009247	HIGH motif; other site
320389009248	KMSKS motif; other site
320389009249	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
320389009250	tRNA binding surface [nucleotide binding]; other site
320389009251	anticodon binding site; other site
320389009252	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
320389009253	dimer interface [polypeptide binding]; other site
320389009254	putative tRNA-binding site [nucleotide binding]; other site
320389009255	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
320389009256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389009257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
320389009258	Family of unknown function (DUF490); Region: DUF490; pfam04357
320389009259	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
320389009260	Surface antigen; Region: Bac_surface_Ag; pfam01103
320389009261	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
320389009262	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
320389009263	pantoate--beta-alanine ligase; Region: panC; TIGR00018
320389009264	Pantoate-beta-alanine ligase; Region: PanC; cd00560
320389009265	active site
320389009266	ATP-binding site [chemical binding]; other site
320389009267	pantoate-binding site; other site
320389009268	HXXH motif; other site
320389009269	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
320389009270	tetramerization interface [polypeptide binding]; other site
320389009271	active site
320389009272	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
320389009273	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
320389009274	P-loop; other site
320389009275	Magnesium ion binding site [ion binding]; other site
320389009276	DoxX; Region: DoxX; pfam07681
320389009277	cobyric acid synthase; Provisional; Region: PRK00784
320389009278	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
320389009279	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
320389009280	catalytic triad [active]
320389009281	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
320389009282	homotrimer interface [polypeptide binding]; other site
320389009283	Walker A motif; other site
320389009284	GTP binding site [chemical binding]; other site
320389009285	Walker B motif; other site
320389009286	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
320389009287	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
320389009288	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
320389009289	cobalamin binding residues [chemical binding]; other site
320389009290	putative BtuC binding residues; other site
320389009291	dimer interface [polypeptide binding]; other site
320389009292	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
320389009293	catalytic core [active]
320389009294	cobalamin synthase; Reviewed; Region: cobS; PRK00235
320389009295	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
320389009296	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
320389009297	putative dimer interface [polypeptide binding]; other site
320389009298	active site pocket [active]
320389009299	putative cataytic base [active]
320389009300	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
320389009301	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
320389009302	Walker A/P-loop; other site
320389009303	ATP binding site [chemical binding]; other site
320389009304	Q-loop/lid; other site
320389009305	ABC transporter signature motif; other site
320389009306	Walker B; other site
320389009307	D-loop; other site
320389009308	H-loop/switch region; other site
320389009309	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
320389009310	ABC-ATPase subunit  interface; other site
320389009311	dimer interface [polypeptide binding]; other site
320389009312	putative PBP binding regions; other site
320389009313	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
320389009314	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389009315	N-terminal plug; other site
320389009316	ligand-binding site [chemical binding]; other site
320389009317	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
320389009318	Cell division protein ZapA; Region: ZapA; pfam05164
320389009319	Uncharacterized conserved protein [Function unknown]; Region: COG2947
320389009320	Protein of unknown function (DUF541); Region: SIMPL; cl01077
320389009321	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
320389009322	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
320389009323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389009324	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
320389009325	putative dimerization interface [polypeptide binding]; other site
320389009326	putative substrate binding pocket [chemical binding]; other site
320389009327	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
320389009328	Transposase domain (DUF772); Region: DUF772; pfam05598
320389009329	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389009330	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389009331	Cytochrome c; Region: Cytochrom_C; cl11414
320389009332	Protein of unknown function (DUF2486); Region: DUF2486; pfam10667
320389009333	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
320389009334	multifunctional aminopeptidase A; Provisional; Region: PRK00913
320389009335	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
320389009336	interface (dimer of trimers) [polypeptide binding]; other site
320389009337	Substrate-binding/catalytic site; other site
320389009338	Zn-binding sites [ion binding]; other site
320389009339	Predicted permeases [General function prediction only]; Region: COG0795
320389009340	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
320389009341	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
320389009342	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
320389009343	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
320389009344	putative active site [active]
320389009345	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
320389009346	active site
320389009347	SAM binding site [chemical binding]; other site
320389009348	homodimer interface [polypeptide binding]; other site
320389009349	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
320389009350	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
320389009351	CysD dimerization site [polypeptide binding]; other site
320389009352	G1 box; other site
320389009353	putative GEF interaction site [polypeptide binding]; other site
320389009354	GTP/Mg2+ binding site [chemical binding]; other site
320389009355	Switch I region; other site
320389009356	G2 box; other site
320389009357	G3 box; other site
320389009358	Switch II region; other site
320389009359	G4 box; other site
320389009360	G5 box; other site
320389009361	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
320389009362	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
320389009363	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
320389009364	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
320389009365	Active Sites [active]
320389009366	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
320389009367	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
320389009368	Active Sites [active]
320389009369	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
320389009370	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
320389009371	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389009372	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389009373	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
320389009374	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389009375	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
320389009376	substrate binding site [chemical binding]; other site
320389009377	dimerization interface [polypeptide binding]; other site
320389009378	HTH-like domain; Region: HTH_21; pfam13276
320389009379	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009380	Integrase core domain; Region: rve; pfam00665
320389009381	Integrase core domain; Region: rve_3; pfam13683
320389009382	Transposase; Region: HTH_Tnp_1; pfam01527
320389009383	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
320389009384	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
320389009385	Peptidase C26; Region: Peptidase_C26; pfam07722
320389009386	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
320389009387	catalytic triad [active]
320389009388	N-formylglutamate amidohydrolase; Region: FGase; cl01522
320389009389	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
320389009390	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
320389009391	active site
320389009392	imidazolonepropionase; Validated; Region: PRK09356
320389009393	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
320389009394	active site
320389009395	HutD; Region: HutD; pfam05962
320389009396	urocanate hydratase; Provisional; Region: PRK05414
320389009397	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
320389009398	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389009399	DNA-binding site [nucleotide binding]; DNA binding site
320389009400	UTRA domain; Region: UTRA; pfam07702
320389009401	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
320389009402	active sites [active]
320389009403	tetramer interface [polypeptide binding]; other site
320389009404	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
320389009405	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
320389009406	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
320389009407	Autoinducer binding domain; Region: Autoind_bind; pfam03472
320389009408	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389009409	DNA binding residues [nucleotide binding]
320389009410	dimerization interface [polypeptide binding]; other site
320389009411	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
320389009412	ligand-binding site [chemical binding]; other site
320389009413	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
320389009414	DNA photolyase; Region: DNA_photolyase; pfam00875
320389009415	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
320389009416	Fatty acid desaturase; Region: FA_desaturase; pfam00487
320389009417	Di-iron ligands [ion binding]; other site
320389009418	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
320389009419	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
320389009420	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
320389009421	Class III ribonucleotide reductase; Region: RNR_III; cd01675
320389009422	effector binding site; other site
320389009423	active site
320389009424	Zn binding site [ion binding]; other site
320389009425	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
320389009426	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
320389009427	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389009428	FeS/SAM binding site; other site
320389009429	DGC domain; Region: DGC; pfam08859
320389009430	SCP-2 sterol transfer family; Region: SCP2; cl01225
320389009431	putative protease; Provisional; Region: PRK15447
320389009432	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
320389009433	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
320389009434	Peptidase family U32; Region: Peptidase_U32; pfam01136
320389009435	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
320389009436	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
320389009437	FMN binding site [chemical binding]; other site
320389009438	substrate binding site [chemical binding]; other site
320389009439	putative catalytic residue [active]
320389009440	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
320389009441	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
320389009442	ligand binding site [chemical binding]; other site
320389009443	flexible hinge region; other site
320389009444	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
320389009445	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
320389009446	HemN C-terminal domain; Region: HemN_C; pfam06969
320389009447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389009448	dimerization interface [polypeptide binding]; other site
320389009449	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389009450	dimer interface [polypeptide binding]; other site
320389009451	putative CheW interface [polypeptide binding]; other site
320389009452	NnrS protein; Region: NnrS; pfam05940
320389009453	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
320389009454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389009455	Walker A/P-loop; other site
320389009456	ATP binding site [chemical binding]; other site
320389009457	ABC transporter signature motif; other site
320389009458	Walker B; other site
320389009459	D-loop; other site
320389009460	H-loop/switch region; other site
320389009461	FeS assembly protein SufD; Region: sufD; TIGR01981
320389009462	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
320389009463	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
320389009464	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
320389009465	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389009466	catalytic residue [active]
320389009467	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
320389009468	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
320389009469	trimerization site [polypeptide binding]; other site
320389009470	active site
320389009471	Domain of unknown function DUF59; Region: DUF59; cl00941
320389009472	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
320389009473	Transcriptional regulator; Region: Rrf2; cl17282
320389009474	Rrf2 family protein; Region: rrf2_super; TIGR00738
320389009475	Hemerythrin; Region: Hemerythrin; cd12107
320389009476	Fe binding site [ion binding]; other site
320389009477	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
320389009478	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
320389009479	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
320389009480	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
320389009481	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
320389009482	Fatty acid desaturase; Region: FA_desaturase; pfam00487
320389009483	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
320389009484	putative di-iron ligands [ion binding]; other site
320389009485	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
320389009486	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389009487	substrate binding pocket [chemical binding]; other site
320389009488	membrane-bound complex binding site; other site
320389009489	hinge residues; other site
320389009490	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
320389009491	dimer interface [polypeptide binding]; other site
320389009492	N-terminal domain interface [polypeptide binding]; other site
320389009493	substrate binding pocket (H-site) [chemical binding]; other site
320389009494	succinylglutamate desuccinylase; Provisional; Region: PRK05324
320389009495	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
320389009496	active site
320389009497	Zn binding site [ion binding]; other site
320389009498	succinylarginine dihydrolase; Provisional; Region: PRK13281
320389009499	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
320389009500	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
320389009501	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
320389009502	arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245
320389009503	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
320389009504	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389009505	inhibitor-cofactor binding pocket; inhibition site
320389009506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389009507	catalytic residue [active]
320389009508	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
320389009509	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
320389009510	conserved cys residue [active]
320389009511	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389009512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389009513	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
320389009514	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389009515	Walker A/P-loop; other site
320389009516	ATP binding site [chemical binding]; other site
320389009517	Q-loop/lid; other site
320389009518	ABC transporter signature motif; other site
320389009519	Walker B; other site
320389009520	D-loop; other site
320389009521	H-loop/switch region; other site
320389009522	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389009523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389009524	dimer interface [polypeptide binding]; other site
320389009525	conserved gate region; other site
320389009526	putative PBP binding loops; other site
320389009527	ABC-ATPase subunit interface; other site
320389009528	HTH-like domain; Region: HTH_21; pfam13276
320389009529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009530	Integrase core domain; Region: rve; pfam00665
320389009531	Integrase core domain; Region: rve_3; pfam13683
320389009532	Transposase; Region: HTH_Tnp_1; pfam01527
320389009533	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
320389009534	Phosphoesterase family; Region: Phosphoesterase; pfam04185
320389009535	Domain of unknown function (DUF756); Region: DUF756; pfam05506
320389009536	Domain of unknown function (DUF756); Region: DUF756; pfam05506
320389009537	pyridoxamine kinase; Validated; Region: PRK05756
320389009538	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
320389009539	dimer interface [polypeptide binding]; other site
320389009540	pyridoxal binding site [chemical binding]; other site
320389009541	ATP binding site [chemical binding]; other site
320389009542	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389009543	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
320389009544	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
320389009545	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
320389009546	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
320389009547	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
320389009548	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
320389009549	ligand binding site; other site
320389009550	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
320389009551	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
320389009552	B12 binding site [chemical binding]; other site
320389009553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389009554	FeS/SAM binding site; other site
320389009555	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
320389009556	putative active site [active]
320389009557	YdjC motif; other site
320389009558	Mg binding site [ion binding]; other site
320389009559	putative homodimer interface [polypeptide binding]; other site
320389009560	putative membrane protein; Region: HpnL; TIGR03476
320389009561	Transposase; Region: HTH_Tnp_1; pfam01527
320389009562	HTH-like domain; Region: HTH_21; pfam13276
320389009563	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009564	Integrase core domain; Region: rve; pfam00665
320389009565	Integrase core domain; Region: rve_3; pfam13683
320389009566	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
320389009567	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
320389009568	dimerization interface [polypeptide binding]; other site
320389009569	ligand binding site [chemical binding]; other site
320389009570	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
320389009571	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
320389009572	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389009573	putative ADP-binding pocket [chemical binding]; other site
320389009574	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
320389009575	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
320389009576	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
320389009577	Walker A/P-loop; other site
320389009578	ATP binding site [chemical binding]; other site
320389009579	Q-loop/lid; other site
320389009580	ABC transporter signature motif; other site
320389009581	Walker B; other site
320389009582	D-loop; other site
320389009583	H-loop/switch region; other site
320389009584	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
320389009585	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
320389009586	active site
320389009587	homotetramer interface [polypeptide binding]; other site
320389009588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389009589	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
320389009590	active site
320389009591	motif I; other site
320389009592	motif II; other site
320389009593	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
320389009594	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
320389009595	Cu(I) binding site [ion binding]; other site
320389009596	Protein of unknown function (DUF461); Region: DUF461; pfam04314
320389009597	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
320389009598	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389009599	Pirin-related protein [General function prediction only]; Region: COG1741
320389009600	Pirin; Region: Pirin; pfam02678
320389009601	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
320389009602	LysR family transcriptional regulator; Provisional; Region: PRK14997
320389009603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389009604	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
320389009605	putative effector binding pocket; other site
320389009606	putative dimerization interface [polypeptide binding]; other site
320389009607	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
320389009608	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
320389009609	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
320389009610	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
320389009611	GIY-YIG motif/motif A; other site
320389009612	active site
320389009613	catalytic site [active]
320389009614	putative DNA binding site [nucleotide binding]; other site
320389009615	metal binding site [ion binding]; metal-binding site
320389009616	UvrB/uvrC motif; Region: UVR; pfam02151
320389009617	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
320389009618	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
320389009619	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
320389009620	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
320389009621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
320389009622	elongation factor P; Validated; Region: PRK00529
320389009623	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
320389009624	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
320389009625	RNA binding site [nucleotide binding]; other site
320389009626	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
320389009627	RNA binding site [nucleotide binding]; other site
320389009628	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389009629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389009630	active site
320389009631	phosphorylation site [posttranslational modification]
320389009632	intermolecular recognition site; other site
320389009633	dimerization interface [polypeptide binding]; other site
320389009634	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389009635	Walker A motif; other site
320389009636	ATP binding site [chemical binding]; other site
320389009637	Walker B motif; other site
320389009638	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389009639	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
320389009640	beta-hexosaminidase; Provisional; Region: PRK05337
320389009641	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
320389009642	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
320389009643	active site
320389009644	hydrophilic channel; other site
320389009645	dimerization interface [polypeptide binding]; other site
320389009646	catalytic residues [active]
320389009647	active site lid [active]
320389009648	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
320389009649	Recombination protein O N terminal; Region: RecO_N; pfam11967
320389009650	Recombination protein O C terminal; Region: RecO_C; pfam02565
320389009651	GTPase Era; Reviewed; Region: era; PRK00089
320389009652	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
320389009653	G1 box; other site
320389009654	GTP/Mg2+ binding site [chemical binding]; other site
320389009655	Switch I region; other site
320389009656	G2 box; other site
320389009657	Switch II region; other site
320389009658	G3 box; other site
320389009659	G4 box; other site
320389009660	G5 box; other site
320389009661	KH domain; Region: KH_2; pfam07650
320389009662	ribonuclease III; Provisional; Region: PRK14718
320389009663	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
320389009664	dimerization interface [polypeptide binding]; other site
320389009665	active site
320389009666	metal binding site [ion binding]; metal-binding site
320389009667	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
320389009668	signal peptidase I; Provisional; Region: PRK10861
320389009669	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
320389009670	Catalytic site [active]
320389009671	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
320389009672	GTP-binding protein LepA; Provisional; Region: PRK05433
320389009673	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
320389009674	G1 box; other site
320389009675	putative GEF interaction site [polypeptide binding]; other site
320389009676	GTP/Mg2+ binding site [chemical binding]; other site
320389009677	Switch I region; other site
320389009678	G2 box; other site
320389009679	G3 box; other site
320389009680	Switch II region; other site
320389009681	G4 box; other site
320389009682	G5 box; other site
320389009683	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
320389009684	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
320389009685	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
320389009686	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
320389009687	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
320389009688	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
320389009689	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
320389009690	protein binding site [polypeptide binding]; other site
320389009691	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
320389009692	protein binding site [polypeptide binding]; other site
320389009693	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
320389009694	anti-sigma E factor; Provisional; Region: rseB; PRK09455
320389009695	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
320389009696	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
320389009697	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389009698	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389009699	DNA binding residues [nucleotide binding]
320389009700	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
320389009701	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
320389009702	dimer interface [polypeptide binding]; other site
320389009703	active site
320389009704	acyl carrier protein; Provisional; Region: acpP; PRK00982
320389009705	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
320389009706	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
320389009707	NAD(P) binding site [chemical binding]; other site
320389009708	homotetramer interface [polypeptide binding]; other site
320389009709	homodimer interface [polypeptide binding]; other site
320389009710	active site
320389009711	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
320389009712	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
320389009713	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
320389009714	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
320389009715	dimer interface [polypeptide binding]; other site
320389009716	active site
320389009717	CoA binding pocket [chemical binding]; other site
320389009718	putative phosphate acyltransferase; Provisional; Region: PRK05331
320389009719	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
320389009720	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
320389009721	Maf-like protein; Region: Maf; pfam02545
320389009722	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
320389009723	active site
320389009724	dimer interface [polypeptide binding]; other site
320389009725	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
320389009726	putative SAM binding site [chemical binding]; other site
320389009727	homodimer interface [polypeptide binding]; other site
320389009728	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
320389009729	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
320389009730	tandem repeat interface [polypeptide binding]; other site
320389009731	oligomer interface [polypeptide binding]; other site
320389009732	active site residues [active]
320389009733	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
320389009734	iron-sulfur cluster [ion binding]; other site
320389009735	[2Fe-2S] cluster binding site [ion binding]; other site
320389009736	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
320389009737	S4 domain; Region: S4; pfam01479
320389009738	RNA binding surface [nucleotide binding]; other site
320389009739	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
320389009740	active site
320389009741	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
320389009742	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
320389009743	homodimer interface [polypeptide binding]; other site
320389009744	oligonucleotide binding site [chemical binding]; other site
320389009745	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
320389009746	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389009747	FeS/SAM binding site; other site
320389009748	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
320389009749	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
320389009750	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
320389009751	GTP binding site; other site
320389009752	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
320389009753	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
320389009754	dimer interface [polypeptide binding]; other site
320389009755	putative functional site; other site
320389009756	putative MPT binding site; other site
320389009757	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
320389009758	RmuC family; Region: RmuC; pfam02646
320389009759	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
320389009760	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
320389009761	dimerization interface [polypeptide binding]; other site
320389009762	ligand binding site [chemical binding]; other site
320389009763	NADP binding site [chemical binding]; other site
320389009764	catalytic site [active]
320389009765	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
320389009766	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
320389009767	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
320389009768	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
320389009769	active site
320389009770	Ferredoxin [Energy production and conversion]; Region: COG1146
320389009771	4Fe-4S binding domain; Region: Fer4; cl02805
320389009772	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
320389009773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
320389009774	CreA protein; Region: CreA; pfam05981
320389009775	Protein of unknown function (DUF4088); Region: DUF4088; pfam13317
320389009776	S4 domain; Region: S4_2; pfam13275
320389009777	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
320389009778	multidrug efflux protein; Reviewed; Region: PRK01766
320389009779	cation binding site [ion binding]; other site
320389009780	Transposase; Region: HTH_Tnp_1; pfam01527
320389009781	HTH-like domain; Region: HTH_21; pfam13276
320389009782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009783	Integrase core domain; Region: rve; pfam00665
320389009784	Integrase core domain; Region: rve_3; pfam13683
320389009785	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
320389009786	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
320389009787	NAD(P) binding site [chemical binding]; other site
320389009788	homodimer interface [polypeptide binding]; other site
320389009789	substrate binding site [chemical binding]; other site
320389009790	active site
320389009791	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
320389009792	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
320389009793	Mg++ binding site [ion binding]; other site
320389009794	putative catalytic motif [active]
320389009795	putative substrate binding site [chemical binding]; other site
320389009796	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389009797	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
320389009798	putative NAD(P) binding site [chemical binding]; other site
320389009799	active site
320389009800	putative substrate binding site [chemical binding]; other site
320389009801	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
320389009802	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
320389009803	active site
320389009804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
320389009805	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
320389009806	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
320389009807	Probable Catalytic site; other site
320389009808	metal-binding site
320389009809	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
320389009810	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
320389009811	active site
320389009812	Methyltransferase domain; Region: Methyltransf_23; pfam13489
320389009813	Methyltransferase domain; Region: Methyltransf_12; pfam08242
320389009814	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
320389009815	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
320389009816	active site
320389009817	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
320389009818	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
320389009819	Probable Catalytic site; other site
320389009820	metal-binding site
320389009821	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
320389009822	extended (e) SDRs; Region: SDR_e; cd08946
320389009823	NAD(P) binding site [chemical binding]; other site
320389009824	active site
320389009825	substrate binding site [chemical binding]; other site
320389009826	Acyltransferase family; Region: Acyl_transf_3; pfam01757
320389009827	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
320389009828	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
320389009829	Walker A/P-loop; other site
320389009830	ATP binding site [chemical binding]; other site
320389009831	Q-loop/lid; other site
320389009832	ABC transporter signature motif; other site
320389009833	Walker B; other site
320389009834	D-loop; other site
320389009835	H-loop/switch region; other site
320389009836	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
320389009837	putative carbohydrate binding site [chemical binding]; other site
320389009838	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
320389009839	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
320389009840	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
320389009841	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
320389009842	NADP binding site [chemical binding]; other site
320389009843	active site
320389009844	putative substrate binding site [chemical binding]; other site
320389009845	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
320389009846	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
320389009847	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
320389009848	substrate binding site; other site
320389009849	tetramer interface; other site
320389009850	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
320389009851	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
320389009852	NAD binding site [chemical binding]; other site
320389009853	substrate binding site [chemical binding]; other site
320389009854	homodimer interface [polypeptide binding]; other site
320389009855	active site
320389009856	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
320389009857	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
320389009858	active site
320389009859	metal binding site [ion binding]; metal-binding site
320389009860	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
320389009861	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
320389009862	putative acyl-acceptor binding pocket; other site
320389009863	dihydroorotase; Provisional; Region: PRK07627
320389009864	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389009865	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
320389009866	active site
320389009867	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
320389009868	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
320389009869	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
320389009870	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389009871	active site
320389009872	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
320389009873	hypothetical protein; Validated; Region: PRK00228
320389009874	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
320389009875	dimer interface [polypeptide binding]; other site
320389009876	substrate binding site [chemical binding]; other site
320389009877	ATP binding site [chemical binding]; other site
320389009878	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
320389009879	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
320389009880	ring oligomerisation interface [polypeptide binding]; other site
320389009881	ATP/Mg binding site [chemical binding]; other site
320389009882	stacking interactions; other site
320389009883	hinge regions; other site
320389009884	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
320389009885	oligomerisation interface [polypeptide binding]; other site
320389009886	mobile loop; other site
320389009887	roof hairpin; other site
320389009888	Predicted transcriptional regulators [Transcription]; Region: COG1733
320389009889	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
320389009890	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
320389009891	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
320389009892	putative NAD(P) binding site [chemical binding]; other site
320389009893	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
320389009894	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
320389009895	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
320389009896	Predicted transcriptional regulators [Transcription]; Region: COG1733
320389009897	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389009898	dimerization interface [polypeptide binding]; other site
320389009899	putative DNA binding site [nucleotide binding]; other site
320389009900	putative Zn2+ binding site [ion binding]; other site
320389009901	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
320389009902	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
320389009903	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389009904	non-specific DNA binding site [nucleotide binding]; other site
320389009905	salt bridge; other site
320389009906	sequence-specific DNA binding site [nucleotide binding]; other site
320389009907	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389009908	Coenzyme A binding pocket [chemical binding]; other site
320389009909	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389009910	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
320389009911	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
320389009912	putative active site [active]
320389009913	catalytic site [active]
320389009914	putative metal binding site [ion binding]; other site
320389009915	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
320389009916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009917	putative substrate translocation pore; other site
320389009918	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
320389009919	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
320389009920	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
320389009921	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
320389009922	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
320389009923	BON domain; Region: BON; cl02771
320389009924	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
320389009925	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
320389009926	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
320389009927	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
320389009928	putative catalytic residue [active]
320389009929	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389009930	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389009931	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
320389009932	dimerization interface [polypeptide binding]; other site
320389009933	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
320389009934	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
320389009935	dimer interface [polypeptide binding]; other site
320389009936	putative PBP binding regions; other site
320389009937	ABC-ATPase subunit  interface; other site
320389009938	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
320389009939	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
320389009940	Walker A/P-loop; other site
320389009941	ATP binding site [chemical binding]; other site
320389009942	Q-loop/lid; other site
320389009943	ABC transporter signature motif; other site
320389009944	Walker B; other site
320389009945	D-loop; other site
320389009946	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
320389009947	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
320389009948	N-terminal plug; other site
320389009949	ligand-binding site [chemical binding]; other site
320389009950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
320389009951	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
320389009952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
320389009953	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
320389009954	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
320389009955	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
320389009956	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
320389009957	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389009958	catalytic loop [active]
320389009959	iron binding site [ion binding]; other site
320389009960	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
320389009961	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
320389009962	major facilitator superfamily transporter; Provisional; Region: PRK05122
320389009963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009964	putative substrate translocation pore; other site
320389009965	EamA-like transporter family; Region: EamA; pfam00892
320389009966	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
320389009967	EamA-like transporter family; Region: EamA; pfam00892
320389009968	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389009969	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389009970	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
320389009971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389009972	catalytic residue [active]
320389009973	HTH-like domain; Region: HTH_21; pfam13276
320389009974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389009975	Integrase core domain; Region: rve; pfam00665
320389009976	Integrase core domain; Region: rve_3; pfam13683
320389009977	Transposase; Region: HTH_Tnp_1; pfam01527
320389009978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389009979	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389009980	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389009981	putative effector binding pocket; other site
320389009982	dimerization interface [polypeptide binding]; other site
320389009983	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
320389009984	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
320389009985	putative ligand binding site [chemical binding]; other site
320389009986	putative NAD binding site [chemical binding]; other site
320389009987	catalytic site [active]
320389009988	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
320389009989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009990	putative substrate translocation pore; other site
320389009991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389009992	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389009993	putative substrate translocation pore; other site
320389009994	fumarylacetoacetase; Region: PLN02856
320389009995	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
320389009996	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
320389009997	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
320389009998	benzoate transport; Region: 2A0115; TIGR00895
320389009999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389010000	putative substrate translocation pore; other site
320389010001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389010002	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
320389010003	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
320389010004	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
320389010005	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
320389010006	EAL domain; Region: EAL; pfam00563
320389010007	Uncharacterized conserved protein [Function unknown]; Region: COG3791
320389010008	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389010009	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389010010	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389010011	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
320389010012	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389010013	FAD binding site [chemical binding]; other site
320389010014	substrate binding pocket [chemical binding]; other site
320389010015	catalytic base [active]
320389010016	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
320389010017	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
320389010018	dimer interface [polypeptide binding]; other site
320389010019	decamer (pentamer of dimers) interface [polypeptide binding]; other site
320389010020	catalytic triad [active]
320389010021	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
320389010022	Predicted membrane protein [Function unknown]; Region: COG5393
320389010023	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
320389010024	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
320389010025	Type II transport protein GspH; Region: GspH; pfam12019
320389010026	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
320389010027	ATP cone domain; Region: ATP-cone; pfam03477
320389010028	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
320389010029	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
320389010030	dimer interface [polypeptide binding]; other site
320389010031	active site
320389010032	glycine-pyridoxal phosphate binding site [chemical binding]; other site
320389010033	folate binding site [chemical binding]; other site
320389010034	malonic semialdehyde reductase; Provisional; Region: PRK10538
320389010035	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
320389010036	putative NAD(P) binding site [chemical binding]; other site
320389010037	homodimer interface [polypeptide binding]; other site
320389010038	homotetramer interface [polypeptide binding]; other site
320389010039	active site
320389010040	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
320389010041	active site
320389010042	TolQ protein; Region: tolQ; TIGR02796
320389010043	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
320389010044	TolR protein; Region: tolR; TIGR02801
320389010045	TolA protein; Region: tolA_full; TIGR02794
320389010046	TonB C terminal; Region: TonB_2; pfam13103
320389010047	translocation protein TolB; Provisional; Region: tolB; PRK02889
320389010048	TolB amino-terminal domain; Region: TolB_N; pfam04052
320389010049	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
320389010050	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
320389010051	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
320389010052	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
320389010053	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389010054	ligand binding site [chemical binding]; other site
320389010055	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
320389010056	Tetratricopeptide repeat; Region: TPR_6; pfam13174
320389010057	Transposase; Region: HTH_Tnp_1; pfam01527
320389010058	HTH-like domain; Region: HTH_21; pfam13276
320389010059	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010060	Integrase core domain; Region: rve; pfam00665
320389010061	Integrase core domain; Region: rve_3; pfam13683
320389010062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389010063	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389010064	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389010065	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389010066	trimer interface [polypeptide binding]; other site
320389010067	eyelet of channel; other site
320389010068	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389010069	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389010070	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
320389010071	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
320389010072	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
320389010073	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
320389010074	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
320389010075	Zn2+ binding site [ion binding]; other site
320389010076	Mg2+ binding site [ion binding]; other site
320389010077	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
320389010078	synthetase active site [active]
320389010079	NTP binding site [chemical binding]; other site
320389010080	metal binding site [ion binding]; metal-binding site
320389010081	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
320389010082	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
320389010083	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
320389010084	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
320389010085	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
320389010086	catalytic site [active]
320389010087	G-X2-G-X-G-K; other site
320389010088	hypothetical protein; Provisional; Region: PRK11820
320389010089	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
320389010090	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
320389010091	ribonuclease PH; Reviewed; Region: rph; PRK00173
320389010092	Ribonuclease PH; Region: RNase_PH_bact; cd11362
320389010093	hexamer interface [polypeptide binding]; other site
320389010094	active site
320389010095	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
320389010096	active site
320389010097	dimerization interface [polypeptide binding]; other site
320389010098	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
320389010099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389010100	FeS/SAM binding site; other site
320389010101	HemN C-terminal domain; Region: HemN_C; pfam06969
320389010102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389010103	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389010104	putative substrate translocation pore; other site
320389010105	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389010106	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389010107	putative active site [active]
320389010108	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
320389010109	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
320389010110	putative ion selectivity filter; other site
320389010111	putative pore gating glutamate residue; other site
320389010112	putative H+/Cl- coupling transport residue; other site
320389010113	cell division topological specificity factor MinE; Provisional; Region: PRK13989
320389010114	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
320389010115	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
320389010116	Switch I; other site
320389010117	Switch II; other site
320389010118	septum formation inhibitor; Reviewed; Region: PRK01973
320389010119	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
320389010120	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
320389010121	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
320389010122	seryl-tRNA synthetase; Provisional; Region: PRK05431
320389010123	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
320389010124	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
320389010125	dimer interface [polypeptide binding]; other site
320389010126	active site
320389010127	motif 1; other site
320389010128	motif 2; other site
320389010129	motif 3; other site
320389010130	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
320389010131	recombination factor protein RarA; Reviewed; Region: PRK13342
320389010132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389010133	Walker A motif; other site
320389010134	ATP binding site [chemical binding]; other site
320389010135	Walker B motif; other site
320389010136	arginine finger; other site
320389010137	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
320389010138	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
320389010139	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
320389010140	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
320389010141	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
320389010142	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
320389010143	thioredoxin reductase; Provisional; Region: PRK10262
320389010144	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389010145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
320389010146	Smr domain; Region: Smr; pfam01713
320389010147	Predicted membrane protein [Function unknown]; Region: COG2860
320389010148	UPF0126 domain; Region: UPF0126; pfam03458
320389010149	UPF0126 domain; Region: UPF0126; pfam03458
320389010150	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
320389010151	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
320389010152	Walker A/P-loop; other site
320389010153	ATP binding site [chemical binding]; other site
320389010154	Q-loop/lid; other site
320389010155	ABC transporter signature motif; other site
320389010156	Walker B; other site
320389010157	D-loop; other site
320389010158	H-loop/switch region; other site
320389010159	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
320389010160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389010161	dimer interface [polypeptide binding]; other site
320389010162	conserved gate region; other site
320389010163	putative PBP binding loops; other site
320389010164	ABC-ATPase subunit interface; other site
320389010165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389010166	dimer interface [polypeptide binding]; other site
320389010167	conserved gate region; other site
320389010168	putative PBP binding loops; other site
320389010169	ABC-ATPase subunit interface; other site
320389010170	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
320389010171	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
320389010172	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
320389010173	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
320389010174	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
320389010175	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
320389010176	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
320389010177	putative active site [active]
320389010178	bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101
320389010179	Glucokinase; Region: Glucokinase; pfam02685
320389010180	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389010181	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
320389010182	putative active site [active]
320389010183	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389010184	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389010185	substrate binding pocket [chemical binding]; other site
320389010186	membrane-bound complex binding site; other site
320389010187	hinge residues; other site
320389010188	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389010189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389010190	dimer interface [polypeptide binding]; other site
320389010191	conserved gate region; other site
320389010192	putative PBP binding loops; other site
320389010193	ABC-ATPase subunit interface; other site
320389010194	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
320389010195	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389010196	Walker A/P-loop; other site
320389010197	ATP binding site [chemical binding]; other site
320389010198	Q-loop/lid; other site
320389010199	ABC transporter signature motif; other site
320389010200	Walker B; other site
320389010201	D-loop; other site
320389010202	H-loop/switch region; other site
320389010203	D-cysteine desulfhydrase; Validated; Region: PRK03910
320389010204	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
320389010205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389010206	catalytic residue [active]
320389010207	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
320389010208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389010209	putative substrate translocation pore; other site
320389010210	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
320389010211	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389010212	inhibitor-cofactor binding pocket; inhibition site
320389010213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389010214	catalytic residue [active]
320389010215	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
320389010216	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
320389010217	catalytic motif [active]
320389010218	Zn binding site [ion binding]; other site
320389010219	RibD C-terminal domain; Region: RibD_C; cl17279
320389010220	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
320389010221	Lumazine binding domain; Region: Lum_binding; pfam00677
320389010222	Lumazine binding domain; Region: Lum_binding; pfam00677
320389010223	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
320389010224	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
320389010225	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
320389010226	dimerization interface [polypeptide binding]; other site
320389010227	active site
320389010228	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
320389010229	homopentamer interface [polypeptide binding]; other site
320389010230	active site
320389010231	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
320389010232	putative RNA binding site [nucleotide binding]; other site
320389010233	aminotransferase; Validated; Region: PRK07337
320389010234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389010235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389010236	homodimer interface [polypeptide binding]; other site
320389010237	catalytic residue [active]
320389010238	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
320389010239	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
320389010240	N-acetyl-D-glucosamine binding site [chemical binding]; other site
320389010241	catalytic residue [active]
320389010242	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
320389010243	LysE type translocator; Region: LysE; cl00565
320389010244	serine racemase; Region: PLN02970
320389010245	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
320389010246	tetramer interface [polypeptide binding]; other site
320389010247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389010248	catalytic residue [active]
320389010249	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
320389010250	Rossmann-like domain; Region: Rossmann-like; pfam10727
320389010251	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
320389010252	YGGT family; Region: YGGT; pfam02325
320389010253	YGGT family; Region: YGGT; pfam02325
320389010254	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
320389010255	chromosome condensation membrane protein; Provisional; Region: PRK14196
320389010256	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
320389010257	active site
320389010258	catalytic triad [active]
320389010259	calcium binding site [ion binding]; other site
320389010260	Transposase domain (DUF772); Region: DUF772; pfam05598
320389010261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389010262	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389010263	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389010264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389010265	S-adenosylmethionine binding site [chemical binding]; other site
320389010266	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
320389010267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389010268	S-adenosylmethionine binding site [chemical binding]; other site
320389010269	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
320389010270	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
320389010271	Flagellin N-methylase; Region: FliB; pfam03692
320389010272	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
320389010273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389010274	FeS/SAM binding site; other site
320389010275	HemN C-terminal domain; Region: HemN_C; pfam06969
320389010276	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
320389010277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
320389010278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389010279	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
320389010280	active site residue [active]
320389010281	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
320389010282	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389010283	inhibitor-cofactor binding pocket; inhibition site
320389010284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389010285	catalytic residue [active]
320389010286	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
320389010287	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
320389010288	putative ligand binding site [chemical binding]; other site
320389010289	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
320389010290	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389010291	TM-ABC transporter signature motif; other site
320389010292	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
320389010293	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
320389010294	TM-ABC transporter signature motif; other site
320389010295	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
320389010296	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
320389010297	Walker A/P-loop; other site
320389010298	ATP binding site [chemical binding]; other site
320389010299	Q-loop/lid; other site
320389010300	ABC transporter signature motif; other site
320389010301	Walker B; other site
320389010302	D-loop; other site
320389010303	H-loop/switch region; other site
320389010304	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
320389010305	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
320389010306	Walker A/P-loop; other site
320389010307	ATP binding site [chemical binding]; other site
320389010308	Q-loop/lid; other site
320389010309	ABC transporter signature motif; other site
320389010310	Walker B; other site
320389010311	D-loop; other site
320389010312	H-loop/switch region; other site
320389010313	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
320389010314	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
320389010315	alpha-gamma subunit interface [polypeptide binding]; other site
320389010316	beta-gamma subunit interface [polypeptide binding]; other site
320389010317	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
320389010318	gamma-beta subunit interface [polypeptide binding]; other site
320389010319	alpha-beta subunit interface [polypeptide binding]; other site
320389010320	urease subunit alpha; Reviewed; Region: ureC; PRK13207
320389010321	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
320389010322	subunit interactions [polypeptide binding]; other site
320389010323	active site
320389010324	flap region; other site
320389010325	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
320389010326	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
320389010327	dimer interface [polypeptide binding]; other site
320389010328	catalytic residues [active]
320389010329	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
320389010330	UreF; Region: UreF; pfam01730
320389010331	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
320389010332	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
320389010333	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
320389010334	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389010335	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
320389010336	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
320389010337	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
320389010338	putative active site [active]
320389010339	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
320389010340	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
320389010341	active site
320389010342	substrate binding site [chemical binding]; other site
320389010343	metal binding site [ion binding]; metal-binding site
320389010344	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
320389010345	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
320389010346	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
320389010347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
320389010348	active site
320389010349	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
320389010350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389010351	putative ADP-binding pocket [chemical binding]; other site
320389010352	UDP-glucose 4-epimerase; Region: PLN02240
320389010353	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
320389010354	NAD binding site [chemical binding]; other site
320389010355	homodimer interface [polypeptide binding]; other site
320389010356	active site
320389010357	substrate binding site [chemical binding]; other site
320389010358	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
320389010359	Mg++ binding site [ion binding]; other site
320389010360	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
320389010361	putative catalytic motif [active]
320389010362	Transposase; Region: HTH_Tnp_1; pfam01527
320389010363	HTH-like domain; Region: HTH_21; pfam13276
320389010364	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010365	Integrase core domain; Region: rve; pfam00665
320389010366	Integrase core domain; Region: rve_3; pfam13683
320389010367	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
320389010368	homotrimer interaction site [polypeptide binding]; other site
320389010369	putative active site [active]
320389010370	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
320389010371	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
320389010372	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389010373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389010374	metal binding site [ion binding]; metal-binding site
320389010375	active site
320389010376	I-site; other site
320389010377	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
320389010378	Chromate transporter; Region: Chromate_transp; pfam02417
320389010379	Chromate transporter; Region: Chromate_transp; pfam02417
320389010380	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
320389010381	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
320389010382	active site
320389010383	Zn binding site [ion binding]; other site
320389010384	allantoate amidohydrolase; Reviewed; Region: PRK12893
320389010385	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
320389010386	active site
320389010387	metal binding site [ion binding]; metal-binding site
320389010388	dimer interface [polypeptide binding]; other site
320389010389	metabolite-proton symporter; Region: 2A0106; TIGR00883
320389010390	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389010391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389010392	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389010393	dimerization interface [polypeptide binding]; other site
320389010394	Predicted membrane protein [Function unknown]; Region: COG4125
320389010395	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
320389010396	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
320389010397	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389010398	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389010399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389010400	dimerization interface [polypeptide binding]; other site
320389010401	Predicted integral membrane protein [Function unknown]; Region: COG5615
320389010402	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
320389010403	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
320389010404	CAP-like domain; other site
320389010405	active site
320389010406	primary dimer interface [polypeptide binding]; other site
320389010407	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
320389010408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389010409	ATP binding site [chemical binding]; other site
320389010410	Mg2+ binding site [ion binding]; other site
320389010411	G-X-G motif; other site
320389010412	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
320389010413	anchoring element; other site
320389010414	dimer interface [polypeptide binding]; other site
320389010415	ATP binding site [chemical binding]; other site
320389010416	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
320389010417	active site
320389010418	metal binding site [ion binding]; metal-binding site
320389010419	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
320389010420	ABC transporter ATPase component; Reviewed; Region: PRK11147
320389010421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389010422	Walker A/P-loop; other site
320389010423	ATP binding site [chemical binding]; other site
320389010424	Q-loop/lid; other site
320389010425	ABC transporter signature motif; other site
320389010426	Walker B; other site
320389010427	D-loop; other site
320389010428	H-loop/switch region; other site
320389010429	ABC transporter; Region: ABC_tran_2; pfam12848
320389010430	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389010431	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
320389010432	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
320389010433	Rubredoxin; Region: Rubredoxin; pfam00301
320389010434	iron binding site [ion binding]; other site
320389010435	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
320389010436	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
320389010437	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
320389010438	HTH-like domain; Region: HTH_21; pfam13276
320389010439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010440	Integrase core domain; Region: rve; pfam00665
320389010441	Integrase core domain; Region: rve_3; pfam13683
320389010442	Transposase; Region: HTH_Tnp_1; pfam01527
320389010443	Transposase domain (DUF772); Region: DUF772; pfam05598
320389010444	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389010445	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389010446	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
320389010447	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
320389010448	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
320389010449	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
320389010450	hypothetical protein; Reviewed; Region: PRK00024
320389010451	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
320389010452	MPN+ (JAMM) motif; other site
320389010453	Zinc-binding site [ion binding]; other site
320389010454	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
320389010455	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
320389010456	L-aspartate oxidase; Provisional; Region: PRK09077
320389010457	L-aspartate oxidase; Provisional; Region: PRK06175
320389010458	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
320389010459	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
320389010460	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
320389010461	dimerization interface [polypeptide binding]; other site
320389010462	active site
320389010463	quinolinate synthetase; Provisional; Region: PRK09375
320389010464	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
320389010465	Fatty acid desaturase; Region: FA_desaturase; pfam00487
320389010466	Di-iron ligands [ion binding]; other site
320389010467	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389010468	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
320389010469	Mechanosensitive ion channel; Region: MS_channel; pfam00924
320389010470	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
320389010471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389010472	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
320389010473	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
320389010474	active site
320389010475	substrate binding site [chemical binding]; other site
320389010476	cosubstrate binding site; other site
320389010477	catalytic site [active]
320389010478	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
320389010479	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
320389010480	active site
320389010481	Riboflavin kinase; Region: Flavokinase; smart00904
320389010482	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
320389010483	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
320389010484	active site
320389010485	HIGH motif; other site
320389010486	nucleotide binding site [chemical binding]; other site
320389010487	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
320389010488	active site
320389010489	KMSKS motif; other site
320389010490	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
320389010491	tRNA binding surface [nucleotide binding]; other site
320389010492	anticodon binding site; other site
320389010493	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
320389010494	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
320389010495	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
320389010496	Flavoprotein; Region: Flavoprotein; pfam02441
320389010497	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
320389010498	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
320389010499	trimer interface [polypeptide binding]; other site
320389010500	active site
320389010501	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
320389010502	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389010503	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389010504	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389010505	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
320389010506	Transposase; Region: HTH_Tnp_1; pfam01527
320389010507	HTH-like domain; Region: HTH_21; pfam13276
320389010508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010509	Integrase core domain; Region: rve; pfam00665
320389010510	Integrase core domain; Region: rve_3; pfam13683
320389010511	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
320389010512	elongation factor G; Reviewed; Region: PRK00007
320389010513	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
320389010514	G1 box; other site
320389010515	putative GEF interaction site [polypeptide binding]; other site
320389010516	GTP/Mg2+ binding site [chemical binding]; other site
320389010517	Switch I region; other site
320389010518	G2 box; other site
320389010519	G3 box; other site
320389010520	Switch II region; other site
320389010521	G4 box; other site
320389010522	G5 box; other site
320389010523	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
320389010524	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
320389010525	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
320389010526	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
320389010527	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
320389010528	active site
320389010529	catalytic tetrad [active]
320389010530	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
320389010531	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389010532	DNA-binding site [nucleotide binding]; DNA binding site
320389010533	UTRA domain; Region: UTRA; pfam07702
320389010534	Helix-turn-helix domain; Region: HTH_17; pfam12728
320389010535	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
320389010536	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
320389010537	dimer interface [polypeptide binding]; other site
320389010538	active site
320389010539	oxalacetate/citrate binding site [chemical binding]; other site
320389010540	citrylCoA binding site [chemical binding]; other site
320389010541	coenzyme A binding site [chemical binding]; other site
320389010542	catalytic triad [active]
320389010543	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
320389010544	putative transporter; Provisional; Region: PRK10504
320389010545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389010546	putative substrate translocation pore; other site
320389010547	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
320389010548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389010549	S-adenosylmethionine binding site [chemical binding]; other site
320389010550	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
320389010551	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
320389010552	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
320389010553	Protein of unknown function (DUF962); Region: DUF962; cl01879
320389010554	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
320389010555	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
320389010556	ligand binding site [chemical binding]; other site
320389010557	flexible hinge region; other site
320389010558	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
320389010559	putative switch regulator; other site
320389010560	non-specific DNA interactions [nucleotide binding]; other site
320389010561	DNA binding site [nucleotide binding]
320389010562	sequence specific DNA binding site [nucleotide binding]; other site
320389010563	putative cAMP binding site [chemical binding]; other site
320389010564	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
320389010565	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
320389010566	Chromate transporter; Region: Chromate_transp; pfam02417
320389010567	HTH-like domain; Region: HTH_21; pfam13276
320389010568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010569	Integrase core domain; Region: rve; pfam00665
320389010570	Integrase core domain; Region: rve_3; pfam13683
320389010571	Transposase; Region: HTH_Tnp_1; pfam01527
320389010572	superoxide dismutase; Provisional; Region: PRK10543
320389010573	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
320389010574	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
320389010575	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
320389010576	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
320389010577	generic binding surface II; other site
320389010578	generic binding surface I; other site
320389010579	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
320389010580	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
320389010581	Uncharacterized conserved protein [Function unknown]; Region: COG2835
320389010582	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
320389010583	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
320389010584	Ligand binding site; other site
320389010585	oligomer interface; other site
320389010586	adenylate kinase; Reviewed; Region: adk; PRK00279
320389010587	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
320389010588	AMP-binding site [chemical binding]; other site
320389010589	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
320389010590	Transposase domain (DUF772); Region: DUF772; pfam05598
320389010591	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389010592	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389010593	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
320389010594	DNA-binding site [nucleotide binding]; DNA binding site
320389010595	RNA-binding motif; other site
320389010596	Uncharacterized conserved protein [Function unknown]; Region: COG2127
320389010597	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
320389010598	Clp amino terminal domain; Region: Clp_N; pfam02861
320389010599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389010600	Walker A motif; other site
320389010601	ATP binding site [chemical binding]; other site
320389010602	Walker B motif; other site
320389010603	arginine finger; other site
320389010604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389010605	Walker A motif; other site
320389010606	ATP binding site [chemical binding]; other site
320389010607	Walker B motif; other site
320389010608	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
320389010609	HTH-like domain; Region: HTH_21; pfam13276
320389010610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010611	Integrase core domain; Region: rve; pfam00665
320389010612	Integrase core domain; Region: rve_3; pfam13683
320389010613	Transposase; Region: HTH_Tnp_1; pfam01527
320389010614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389010615	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
320389010616	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
320389010617	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389010618	catalytic residue [active]
320389010619	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187
320389010620	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
320389010621	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
320389010622	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
320389010623	active site
320389010624	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
320389010625	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
320389010626	Methyltransferase domain; Region: Methyltransf_23; pfam13489
320389010627	Methyltransferase domain; Region: Methyltransf_12; pfam08242
320389010628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389010629	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
320389010630	Enoylreductase; Region: PKS_ER; smart00829
320389010631	NAD(P) binding site [chemical binding]; other site
320389010632	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
320389010633	KR domain; Region: KR; pfam08659
320389010634	putative NADP binding site [chemical binding]; other site
320389010635	active site
320389010636	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
320389010637	Sulfatase; Region: Sulfatase; pfam00884
320389010638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389010639	NAD(P) binding site [chemical binding]; other site
320389010640	active site
320389010641	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
320389010642	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
320389010643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389010644	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
320389010645	active site
320389010646	motif I; other site
320389010647	motif II; other site
320389010648	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
320389010649	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
320389010650	Substrate binding site; other site
320389010651	Mg++ binding site; other site
320389010652	metal-binding site
320389010653	Mg++ binding site; other site
320389010654	metal-binding site
320389010655	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389010656	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
320389010657	dimer interface [polypeptide binding]; other site
320389010658	active site
320389010659	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
320389010660	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
320389010661	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
320389010662	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
320389010663	NADP-binding site; other site
320389010664	homotetramer interface [polypeptide binding]; other site
320389010665	substrate binding site [chemical binding]; other site
320389010666	homodimer interface [polypeptide binding]; other site
320389010667	active site
320389010668	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
320389010669	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389010670	NAD(P) binding site [chemical binding]; other site
320389010671	active site
320389010672	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389010673	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389010674	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
320389010675	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
320389010676	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
320389010677	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389010678	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
320389010679	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
320389010680	Walker A/P-loop; other site
320389010681	ATP binding site [chemical binding]; other site
320389010682	Q-loop/lid; other site
320389010683	ABC transporter signature motif; other site
320389010684	Walker B; other site
320389010685	D-loop; other site
320389010686	H-loop/switch region; other site
320389010687	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
320389010688	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
320389010689	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
320389010690	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
320389010691	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
320389010692	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
320389010693	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389010694	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
320389010695	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
320389010696	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
320389010697	Substrate binding site; other site
320389010698	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
320389010699	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
320389010700	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
320389010701	putative active site [active]
320389010702	putative dimer interface [polypeptide binding]; other site
320389010703	mechanosensitive channel MscS; Provisional; Region: PRK10334
320389010704	Mechanosensitive ion channel; Region: MS_channel; pfam00924
320389010705	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
320389010706	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
320389010707	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
320389010708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389010709	ATP binding site [chemical binding]; other site
320389010710	Mg2+ binding site [ion binding]; other site
320389010711	G-X-G motif; other site
320389010712	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
320389010713	ATP binding site [chemical binding]; other site
320389010714	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
320389010715	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
320389010716	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
320389010717	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
320389010718	SnoaL-like domain; Region: SnoaL_3; pfam13474
320389010719	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
320389010720	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
320389010721	dimerization interface [polypeptide binding]; other site
320389010722	putative ATP binding site [chemical binding]; other site
320389010723	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
320389010724	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
320389010725	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
320389010726	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
320389010727	poly(A) polymerase; Region: pcnB; TIGR01942
320389010728	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
320389010729	active site
320389010730	NTP binding site [chemical binding]; other site
320389010731	metal binding triad [ion binding]; metal-binding site
320389010732	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
320389010733	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
320389010734	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
320389010735	catalytic center binding site [active]
320389010736	ATP binding site [chemical binding]; other site
320389010737	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
320389010738	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
320389010739	Substrate-binding site [chemical binding]; other site
320389010740	Substrate specificity [chemical binding]; other site
320389010741	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
320389010742	oligomerization interface [polypeptide binding]; other site
320389010743	active site
320389010744	metal binding site [ion binding]; metal-binding site
320389010745	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
320389010746	chorismate binding enzyme; Region: Chorismate_bind; cl10555
320389010747	hypothetical protein; Provisional; Region: PRK07546
320389010748	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
320389010749	homodimer interface [polypeptide binding]; other site
320389010750	substrate-cofactor binding pocket; other site
320389010751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389010752	catalytic residue [active]
320389010753	chaperone protein DnaJ; Provisional; Region: PRK10767
320389010754	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
320389010755	HSP70 interaction site [polypeptide binding]; other site
320389010756	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
320389010757	Zn binding sites [ion binding]; other site
320389010758	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
320389010759	dimer interface [polypeptide binding]; other site
320389010760	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
320389010761	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
320389010762	nucleotide binding site [chemical binding]; other site
320389010763	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
320389010764	GrpE; Region: GrpE; pfam01025
320389010765	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
320389010766	dimer interface [polypeptide binding]; other site
320389010767	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
320389010768	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389010769	RNA binding surface [nucleotide binding]; other site
320389010770	ferrochelatase; Reviewed; Region: hemH; PRK00035
320389010771	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
320389010772	C-terminal domain interface [polypeptide binding]; other site
320389010773	active site
320389010774	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
320389010775	active site
320389010776	N-terminal domain interface [polypeptide binding]; other site
320389010777	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
320389010778	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
320389010779	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
320389010780	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
320389010781	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
320389010782	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
320389010783	Walker A/P-loop; other site
320389010784	ATP binding site [chemical binding]; other site
320389010785	Q-loop/lid; other site
320389010786	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
320389010787	ABC transporter signature motif; other site
320389010788	Walker B; other site
320389010789	D-loop; other site
320389010790	H-loop/switch region; other site
320389010791	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
320389010792	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
320389010793	metal binding triad; other site
320389010794	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
320389010795	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
320389010796	metal binding triad; other site
320389010797	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
320389010798	TIGR02099 family protein; Region: TIGR02099
320389010799	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
320389010800	nitrilase; Region: PLN02798
320389010801	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
320389010802	putative active site [active]
320389010803	catalytic triad [active]
320389010804	dimer interface [polypeptide binding]; other site
320389010805	protease TldD; Provisional; Region: tldD; PRK10735
320389010806	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
320389010807	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
320389010808	Transposase domain (DUF772); Region: DUF772; pfam05598
320389010809	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389010810	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389010811	glutathione reductase; Validated; Region: PRK06116
320389010812	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389010813	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389010814	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
320389010815	argininosuccinate synthase; Validated; Region: PRK05370
320389010816	argininosuccinate synthase; Provisional; Region: PRK13820
320389010817	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
320389010818	metal-binding site [ion binding]
320389010819	YHS domain; Region: YHS; pfam04945
320389010820	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
320389010821	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
320389010822	Soluble P-type ATPase [General function prediction only]; Region: COG4087
320389010823	LemA family; Region: LemA; pfam04011
320389010824	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
320389010825	Repair protein; Region: Repair_PSII; pfam04536
320389010826	Repair protein; Region: Repair_PSII; pfam04536
320389010827	HlyD family secretion protein; Region: HlyD_2; pfam12700
320389010828	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389010829	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
320389010830	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
320389010831	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
320389010832	Avidin family; Region: Avidin; pfam01382
320389010833	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
320389010834	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
320389010835	glutaminase active site [active]
320389010836	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
320389010837	dimer interface [polypeptide binding]; other site
320389010838	active site
320389010839	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
320389010840	dimer interface [polypeptide binding]; other site
320389010841	active site
320389010842	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
320389010843	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
320389010844	Substrate binding site; other site
320389010845	Mg++ binding site; other site
320389010846	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
320389010847	active site
320389010848	substrate binding site [chemical binding]; other site
320389010849	CoA binding site [chemical binding]; other site
320389010850	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
320389010851	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
320389010852	Ligand Binding Site [chemical binding]; other site
320389010853	Dihydroneopterin aldolase; Region: FolB; smart00905
320389010854	active site
320389010855	short chain dehydrogenase; Provisional; Region: PRK09134
320389010856	Uncharacterized conserved protein [Function unknown]; Region: COG1565
320389010857	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
320389010858	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
320389010859	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
320389010860	putative substrate binding site [chemical binding]; other site
320389010861	putative ATP binding site [chemical binding]; other site
320389010862	dimerization interface [polypeptide binding]; other site
320389010863	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
320389010864	putative active cleft [active]
320389010865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
320389010866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
320389010867	DNA binding site [nucleotide binding]
320389010868	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
320389010869	ligand binding site [chemical binding]; other site
320389010870	dimerization interface [polypeptide binding]; other site
320389010871	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
320389010872	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389010873	dimer interface [polypeptide binding]; other site
320389010874	putative CheW interface [polypeptide binding]; other site
320389010875	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
320389010876	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
320389010877	Transposase; Region: HTH_Tnp_1; pfam01527
320389010878	HTH-like domain; Region: HTH_21; pfam13276
320389010879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010880	Integrase core domain; Region: rve; pfam00665
320389010881	Integrase core domain; Region: rve_3; pfam13683
320389010882	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
320389010883	dimer interface [polypeptide binding]; other site
320389010884	Alkaline phosphatase homologues; Region: alkPPc; smart00098
320389010885	active site
320389010886	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
320389010887	Alkaline phosphatase homologues; Region: alkPPc; smart00098
320389010888	active site
320389010889	dimer interface [polypeptide binding]; other site
320389010890	CutC family; Region: CutC; cl01218
320389010891	biotin synthase; Region: bioB; TIGR00433
320389010892	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389010893	FeS/SAM binding site; other site
320389010894	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
320389010895	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
320389010896	AAA domain; Region: AAA_26; pfam13500
320389010897	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
320389010898	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
320389010899	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
320389010900	catalytic residue [active]
320389010901	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
320389010902	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389010903	inhibitor-cofactor binding pocket; inhibition site
320389010904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389010905	catalytic residue [active]
320389010906	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
320389010907	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
320389010908	hypothetical protein; Provisional; Region: PRK01842
320389010909	short chain dehydrogenase; Provisional; Region: PRK06953
320389010910	NAD(P) binding site [chemical binding]; other site
320389010911	active site
320389010912	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
320389010913	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389010914	dimer interface [polypeptide binding]; other site
320389010915	active site
320389010916	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
320389010917	active site clefts [active]
320389010918	zinc binding site [ion binding]; other site
320389010919	dimer interface [polypeptide binding]; other site
320389010920	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
320389010921	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
320389010922	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
320389010923	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
320389010924	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389010925	Walker A/P-loop; other site
320389010926	ATP binding site [chemical binding]; other site
320389010927	Q-loop/lid; other site
320389010928	ABC transporter signature motif; other site
320389010929	Walker B; other site
320389010930	D-loop; other site
320389010931	H-loop/switch region; other site
320389010932	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
320389010933	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
320389010934	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
320389010935	peptide binding site [polypeptide binding]; other site
320389010936	MarR family; Region: MarR_2; cl17246
320389010937	Transcriptional regulators [Transcription]; Region: MarR; COG1846
320389010938	short chain dehydrogenase; Validated; Region: PRK08264
320389010939	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389010940	NAD(P) binding site [chemical binding]; other site
320389010941	active site
320389010942	short chain dehydrogenase; Provisional; Region: PRK07024
320389010943	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
320389010944	NAD(P) binding site [chemical binding]; other site
320389010945	active site
320389010946	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
320389010947	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
320389010948	catalytic residues [active]
320389010949	hinge region; other site
320389010950	alpha helical domain; other site
320389010951	Sporulation related domain; Region: SPOR; pfam05036
320389010952	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
320389010953	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
320389010954	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
320389010955	active site
320389010956	HIGH motif; other site
320389010957	KMSK motif region; other site
320389010958	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
320389010959	tRNA binding surface [nucleotide binding]; other site
320389010960	anticodon binding site; other site
320389010961	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
320389010962	Transposase domain (DUF772); Region: DUF772; pfam05598
320389010963	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389010964	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389010965	HTH-like domain; Region: HTH_21; pfam13276
320389010966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389010967	Integrase core domain; Region: rve; pfam00665
320389010968	Integrase core domain; Region: rve_3; pfam13683
320389010969	Transposase; Region: HTH_Tnp_1; pfam01527
320389010970	YaeQ protein; Region: YaeQ; pfam07152
320389010971	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
320389010972	dimer interface [polypeptide binding]; other site
320389010973	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389010974	metal binding site [ion binding]; metal-binding site
320389010975	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
320389010976	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
320389010977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389010978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389010979	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
320389010980	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
320389010981	DNA binding site [nucleotide binding]
320389010982	active site
320389010983	AlkA N-terminal domain; Region: AlkA_N; pfam06029
320389010984	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
320389010985	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
320389010986	minor groove reading motif; other site
320389010987	helix-hairpin-helix signature motif; other site
320389010988	substrate binding pocket [chemical binding]; other site
320389010989	active site
320389010990	glutamate--cysteine ligase; Provisional; Region: PRK02107
320389010991	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
320389010992	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389010993	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
320389010994	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389010995	DNA binding residues [nucleotide binding]
320389010996	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
320389010997	dimer interface [polypeptide binding]; other site
320389010998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389010999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011000	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389011001	putative effector binding pocket; other site
320389011002	dimerization interface [polypeptide binding]; other site
320389011003	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
320389011004	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
320389011005	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
320389011006	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
320389011007	active site
320389011008	Zn binding site [ion binding]; other site
320389011009	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
320389011010	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
320389011011	putative active site; other site
320389011012	catalytic triad [active]
320389011013	putative dimer interface [polypeptide binding]; other site
320389011014	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
320389011015	portal vertex protein; Provisional; Region: Q; PHA02536
320389011016	Phage portal protein; Region: Phage_portal; pfam04860
320389011017	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
320389011018	HTH-like domain; Region: HTH_21; pfam13276
320389011019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389011020	Integrase core domain; Region: rve; pfam00665
320389011021	Integrase core domain; Region: rve_3; pfam13683
320389011022	Transposase; Region: HTH_Tnp_1; pfam01527
320389011023	YaeQ protein; Region: YaeQ; pfam07152
320389011024	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
320389011025	dimer interface [polypeptide binding]; other site
320389011026	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389011027	metal binding site [ion binding]; metal-binding site
320389011028	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
320389011029	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
320389011030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389011031	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389011032	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
320389011033	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
320389011034	DNA binding site [nucleotide binding]
320389011035	active site
320389011036	AlkA N-terminal domain; Region: AlkA_N; pfam06029
320389011037	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
320389011038	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
320389011039	minor groove reading motif; other site
320389011040	helix-hairpin-helix signature motif; other site
320389011041	substrate binding pocket [chemical binding]; other site
320389011042	active site
320389011043	glutamate--cysteine ligase; Provisional; Region: PRK02107
320389011044	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
320389011045	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389011046	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
320389011047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389011048	DNA binding residues [nucleotide binding]
320389011049	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
320389011050	dimer interface [polypeptide binding]; other site
320389011051	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389011052	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011053	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389011054	putative effector binding pocket; other site
320389011055	dimerization interface [polypeptide binding]; other site
320389011056	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
320389011057	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
320389011058	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
320389011059	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
320389011060	active site
320389011061	Zn binding site [ion binding]; other site
320389011062	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
320389011063	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
320389011064	putative active site; other site
320389011065	catalytic triad [active]
320389011066	putative dimer interface [polypeptide binding]; other site
320389011067	portal vertex protein; Provisional; Region: Q; PHA02536
320389011068	Phage portal protein; Region: Phage_portal; pfam04860
320389011069	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
320389011070	HTH-like domain; Region: HTH_21; pfam13276
320389011071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389011072	Integrase core domain; Region: rve; pfam00665
320389011073	Integrase core domain; Region: rve_3; pfam13683
320389011074	Transposase; Region: HTH_Tnp_1; pfam01527
320389011075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389011076	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389011077	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
320389011078	CoenzymeA binding site [chemical binding]; other site
320389011079	subunit interaction site [polypeptide binding]; other site
320389011080	PHB binding site; other site
320389011081	Patatin-like phospholipase; Region: Patatin; pfam01734
320389011082	active site
320389011083	nucleophile elbow; other site
320389011084	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
320389011085	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
320389011086	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
320389011087	dimerization interface [polypeptide binding]; other site
320389011088	NAD binding site [chemical binding]; other site
320389011089	ligand binding site [chemical binding]; other site
320389011090	catalytic site [active]
320389011091	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389011092	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011093	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389011094	putative effector binding pocket; other site
320389011095	dimerization interface [polypeptide binding]; other site
320389011096	DNA topoisomerase III; Validated; Region: PRK08173
320389011097	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
320389011098	active site
320389011099	putative interdomain interaction site [polypeptide binding]; other site
320389011100	putative metal-binding site [ion binding]; other site
320389011101	putative nucleotide binding site [chemical binding]; other site
320389011102	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
320389011103	domain I; other site
320389011104	DNA binding groove [nucleotide binding]
320389011105	phosphate binding site [ion binding]; other site
320389011106	domain II; other site
320389011107	domain III; other site
320389011108	nucleotide binding site [chemical binding]; other site
320389011109	catalytic site [active]
320389011110	domain IV; other site
320389011111	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
320389011112	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
320389011113	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
320389011114	catalytic residues [active]
320389011115	DNA protecting protein DprA; Region: dprA; TIGR00732
320389011116	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
320389011117	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
320389011118	active site
320389011119	catalytic residues [active]
320389011120	metal binding site [ion binding]; metal-binding site
320389011121	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
320389011122	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
320389011123	putative active site [active]
320389011124	substrate binding site [chemical binding]; other site
320389011125	putative cosubstrate binding site; other site
320389011126	catalytic site [active]
320389011127	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
320389011128	substrate binding site [chemical binding]; other site
320389011129	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389011130	M48 family peptidase; Provisional; Region: PRK03001
320389011131	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
320389011132	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389011133	dimerization interface [polypeptide binding]; other site
320389011134	PAS domain; Region: PAS; smart00091
320389011135	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
320389011136	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389011137	dimer interface [polypeptide binding]; other site
320389011138	phosphorylation site [posttranslational modification]
320389011139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389011140	ATP binding site [chemical binding]; other site
320389011141	Mg2+ binding site [ion binding]; other site
320389011142	G-X-G motif; other site
320389011143	Response regulator receiver domain; Region: Response_reg; pfam00072
320389011144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389011145	active site
320389011146	phosphorylation site [posttranslational modification]
320389011147	intermolecular recognition site; other site
320389011148	dimerization interface [polypeptide binding]; other site
320389011149	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
320389011150	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
320389011151	Ligand Binding Site [chemical binding]; other site
320389011152	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
320389011153	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
320389011154	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
320389011155	active site
320389011156	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
320389011157	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
320389011158	Sel1 repeat; Region: Sel1; cl02723
320389011159	Sel1-like repeats; Region: SEL1; smart00671
320389011160	Sel1-like repeats; Region: SEL1; smart00671
320389011161	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
320389011162	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
320389011163	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
320389011164	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
320389011165	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
320389011166	rod shape-determining protein MreC; Provisional; Region: PRK13922
320389011167	rod shape-determining protein MreC; Region: MreC; pfam04085
320389011168	rod shape-determining protein MreB; Provisional; Region: PRK13927
320389011169	MreB and similar proteins; Region: MreB_like; cd10225
320389011170	nucleotide binding site [chemical binding]; other site
320389011171	Mg binding site [ion binding]; other site
320389011172	putative protofilament interaction site [polypeptide binding]; other site
320389011173	RodZ interaction site [polypeptide binding]; other site
320389011174	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
320389011175	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
320389011176	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
320389011177	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
320389011178	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
320389011179	GatB domain; Region: GatB_Yqey; smart00845
320389011180	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
320389011181	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
320389011182	putative active site [active]
320389011183	putative catalytic site [active]
320389011184	putative DNA binding site [nucleotide binding]; other site
320389011185	putative phosphate binding site [ion binding]; other site
320389011186	metal binding site A [ion binding]; metal-binding site
320389011187	putative AP binding site [nucleotide binding]; other site
320389011188	putative metal binding site B [ion binding]; other site
320389011189	Transposase domain (DUF772); Region: DUF772; pfam05598
320389011190	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389011191	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389011192	CHRD domain; Region: CHRD; pfam07452
320389011193	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
320389011194	EcsC protein family; Region: EcsC; pfam12787
320389011195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389011196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389011197	putative substrate translocation pore; other site
320389011198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389011199	Transcriptional regulators [Transcription]; Region: MarR; COG1846
320389011200	MarR family; Region: MarR; pfam01047
320389011201	MarR family; Region: MarR_2; cl17246
320389011202	intracellular protease, PfpI family; Region: PfpI; TIGR01382
320389011203	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
320389011204	conserved cys residue [active]
320389011205	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
320389011206	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
320389011207	dimer interface [polypeptide binding]; other site
320389011208	active site
320389011209	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389011210	substrate binding site [chemical binding]; other site
320389011211	catalytic residue [active]
320389011212	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389011213	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389011214	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
320389011215	putative active site [active]
320389011216	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
320389011217	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
320389011218	active site
320389011219	putative substrate binding pocket [chemical binding]; other site
320389011220	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
320389011221	homotrimer interaction site [polypeptide binding]; other site
320389011222	putative active site [active]
320389011223	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
320389011224	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
320389011225	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
320389011226	threonine dehydratase; Reviewed; Region: PRK09224
320389011227	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
320389011228	tetramer interface [polypeptide binding]; other site
320389011229	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389011230	catalytic residue [active]
320389011231	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
320389011232	putative Ile/Val binding site [chemical binding]; other site
320389011233	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
320389011234	putative Ile/Val binding site [chemical binding]; other site
320389011235	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
320389011236	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
320389011237	FAD binding domain; Region: FAD_binding_4; pfam01565
320389011238	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
320389011239	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
320389011240	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
320389011241	Cysteine-rich domain; Region: CCG; pfam02754
320389011242	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
320389011243	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
320389011244	nucleotide binding site/active site [active]
320389011245	HIT family signature motif; other site
320389011246	catalytic residue [active]
320389011247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
320389011248	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
320389011249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389011250	S-adenosylmethionine binding site [chemical binding]; other site
320389011251	Tim44-like domain; Region: Tim44; pfam04280
320389011252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
320389011253	SCP-2 sterol transfer family; Region: SCP2; pfam02036
320389011254	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
320389011255	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
320389011256	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
320389011257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
320389011258	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
320389011259	Uncharacterized conserved protein [Function unknown]; Region: COG2928
320389011260	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
320389011261	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
320389011262	dimer interface [polypeptide binding]; other site
320389011263	anticodon binding site; other site
320389011264	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
320389011265	homodimer interface [polypeptide binding]; other site
320389011266	motif 1; other site
320389011267	active site
320389011268	motif 2; other site
320389011269	GAD domain; Region: GAD; pfam02938
320389011270	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
320389011271	motif 3; other site
320389011272	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
320389011273	nudix motif; other site
320389011274	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
320389011275	PLD-like domain; Region: PLDc_2; pfam13091
320389011276	putative active site [active]
320389011277	catalytic site [active]
320389011278	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
320389011279	PLD-like domain; Region: PLDc_2; pfam13091
320389011280	putative active site [active]
320389011281	catalytic site [active]
320389011282	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389011283	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389011284	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
320389011285	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
320389011286	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
320389011287	FAD binding site [chemical binding]; other site
320389011288	substrate binding site [chemical binding]; other site
320389011289	catalytic residues [active]
320389011290	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
320389011291	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
320389011292	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
320389011293	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389011294	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
320389011295	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389011296	substrate binding site [chemical binding]; other site
320389011297	oxyanion hole (OAH) forming residues; other site
320389011298	trimer interface [polypeptide binding]; other site
320389011299	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
320389011300	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389011301	dimer interface [polypeptide binding]; other site
320389011302	active site
320389011303	enoyl-CoA hydratase; Provisional; Region: PRK06688
320389011304	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389011305	substrate binding site [chemical binding]; other site
320389011306	oxyanion hole (OAH) forming residues; other site
320389011307	trimer interface [polypeptide binding]; other site
320389011308	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
320389011309	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
320389011310	conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664
320389011311	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
320389011312	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
320389011313	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
320389011314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389011315	Walker A/P-loop; other site
320389011316	ATP binding site [chemical binding]; other site
320389011317	Q-loop/lid; other site
320389011318	ABC transporter signature motif; other site
320389011319	Walker B; other site
320389011320	D-loop; other site
320389011321	H-loop/switch region; other site
320389011322	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
320389011323	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
320389011324	Substrate binding site; other site
320389011325	metal-binding site
320389011326	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
320389011327	Phosphotransferase enzyme family; Region: APH; pfam01636
320389011328	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
320389011329	Organic solvent tolerance protein; Region: OstA_C; pfam04453
320389011330	SurA N-terminal domain; Region: SurA_N; pfam09312
320389011331	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
320389011332	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
320389011333	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
320389011334	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
320389011335	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
320389011336	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
320389011337	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
320389011338	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389011339	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
320389011340	dimer interface [polypeptide binding]; other site
320389011341	active site
320389011342	metal binding site [ion binding]; metal-binding site
320389011343	glutathione binding site [chemical binding]; other site
320389011344	Protein of unknown function DUF45; Region: DUF45; pfam01863
320389011345	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
320389011346	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
320389011347	putative acyl-acceptor binding pocket; other site
320389011348	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
320389011349	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389011350	active site
320389011351	motif I; other site
320389011352	motif II; other site
320389011353	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
320389011354	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
320389011355	dimer interface [polypeptide binding]; other site
320389011356	motif 1; other site
320389011357	active site
320389011358	motif 2; other site
320389011359	motif 3; other site
320389011360	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
320389011361	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
320389011362	putative active site [active]
320389011363	catalytic triad [active]
320389011364	putative dimer interface [polypeptide binding]; other site
320389011365	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
320389011366	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
320389011367	Transporter associated domain; Region: CorC_HlyC; smart01091
320389011368	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
320389011369	putative active site pocket [active]
320389011370	dimerization interface [polypeptide binding]; other site
320389011371	putative catalytic residue [active]
320389011372	unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963
320389011373	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
320389011374	PhoH-like protein; Region: PhoH; pfam02562
320389011375	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
320389011376	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
320389011377	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389011378	FeS/SAM binding site; other site
320389011379	TRAM domain; Region: TRAM; pfam01938
320389011380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389011381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011382	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389011383	putative effector binding pocket; other site
320389011384	dimerization interface [polypeptide binding]; other site
320389011385	MFS transport protein AraJ; Provisional; Region: PRK10091
320389011386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389011387	putative substrate translocation pore; other site
320389011388	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
320389011389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
320389011390	non-specific DNA binding site [nucleotide binding]; other site
320389011391	salt bridge; other site
320389011392	sequence-specific DNA binding site [nucleotide binding]; other site
320389011393	Cupin domain; Region: Cupin_2; pfam07883
320389011394	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
320389011395	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
320389011396	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
320389011397	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389011398	motif II; other site
320389011399	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
320389011400	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
320389011401	active site
320389011402	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
320389011403	dimer interface [polypeptide binding]; other site
320389011404	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
320389011405	Ligand Binding Site [chemical binding]; other site
320389011406	Molecular Tunnel; other site
320389011407	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
320389011408	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
320389011409	hinge; other site
320389011410	active site
320389011411	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
320389011412	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
320389011413	putative active site [active]
320389011414	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
320389011415	homotrimer interaction site [polypeptide binding]; other site
320389011416	putative active site [active]
320389011417	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
320389011418	amphipathic channel; other site
320389011419	Asn-Pro-Ala signature motifs; other site
320389011420	glycerol kinase; Provisional; Region: glpK; PRK00047
320389011421	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
320389011422	N- and C-terminal domain interface [polypeptide binding]; other site
320389011423	active site
320389011424	MgATP binding site [chemical binding]; other site
320389011425	catalytic site [active]
320389011426	metal binding site [ion binding]; metal-binding site
320389011427	glycerol binding site [chemical binding]; other site
320389011428	homotetramer interface [polypeptide binding]; other site
320389011429	homodimer interface [polypeptide binding]; other site
320389011430	FBP binding site [chemical binding]; other site
320389011431	protein IIAGlc interface [polypeptide binding]; other site
320389011432	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
320389011433	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
320389011434	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
320389011435	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
320389011436	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
320389011437	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
320389011438	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
320389011439	dinuclear metal binding motif [ion binding]; other site
320389011440	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
320389011441	ATP binding site [chemical binding]; other site
320389011442	Mg++ binding site [ion binding]; other site
320389011443	motif III; other site
320389011444	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389011445	nucleotide binding region [chemical binding]; other site
320389011446	ATP-binding site [chemical binding]; other site
320389011447	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
320389011448	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
320389011449	Cytochrome c; Region: Cytochrom_C; pfam00034
320389011450	Cytochrome c; Region: Cytochrom_C; cl11414
320389011451	Cytochrome c; Region: Cytochrom_C; cl11414
320389011452	Copper resistance protein D; Region: CopD; pfam05425
320389011453	galactonate dehydratase; Provisional; Region: PRK14017
320389011454	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
320389011455	putative active site pocket [active]
320389011456	putative metal binding site [ion binding]; other site
320389011457	Uncharacterized conserved protein [Function unknown]; Region: COG3791
320389011458	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
320389011459	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
320389011460	active site
320389011461	metal binding site [ion binding]; metal-binding site
320389011462	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
320389011463	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
320389011464	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
320389011465	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
320389011466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389011467	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
320389011468	linker region; other site
320389011469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389011470	ATP binding site [chemical binding]; other site
320389011471	Mg2+ binding site [ion binding]; other site
320389011472	G-X-G motif; other site
320389011473	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
320389011474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389011475	active site
320389011476	phosphorylation site [posttranslational modification]
320389011477	intermolecular recognition site; other site
320389011478	dimerization interface [polypeptide binding]; other site
320389011479	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
320389011480	Zn2+ binding site [ion binding]; other site
320389011481	Mg2+ binding site [ion binding]; other site
320389011482	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
320389011483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
320389011484	PAS domain; Region: PAS_9; pfam13426
320389011485	putative active site [active]
320389011486	heme pocket [chemical binding]; other site
320389011487	HAMP domain; Region: HAMP; pfam00672
320389011488	dimerization interface [polypeptide binding]; other site
320389011489	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
320389011490	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389011491	dimer interface [polypeptide binding]; other site
320389011492	putative CheW interface [polypeptide binding]; other site
320389011493	Transposase; Region: HTH_Tnp_1; pfam01527
320389011494	HTH-like domain; Region: HTH_21; pfam13276
320389011495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389011496	Integrase core domain; Region: rve; pfam00665
320389011497	Integrase core domain; Region: rve_3; pfam13683
320389011498	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
320389011499	Tetratricopeptide repeat; Region: TPR_12; pfam13424
320389011500	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
320389011501	phosphopeptide binding site; other site
320389011502	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
320389011503	active site
320389011504	ATP binding site [chemical binding]; other site
320389011505	substrate binding site [chemical binding]; other site
320389011506	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
320389011507	activation loop (A-loop); other site
320389011508	cyclase homology domain; Region: CHD; cd07302
320389011509	dimer interface [polypeptide binding]; other site
320389011510	nucleotidyl binding site; other site
320389011511	metal binding site [ion binding]; metal-binding site
320389011512	AAA ATPase domain; Region: AAA_16; pfam13191
320389011513	ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795
320389011514	ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795
320389011515	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
320389011516	YcaO-like family; Region: YcaO; pfam02624
320389011517	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
320389011518	aldolase II superfamily protein; Provisional; Region: PRK07044
320389011519	intersubunit interface [polypeptide binding]; other site
320389011520	active site
320389011521	Zn2+ binding site [ion binding]; other site
320389011522	PAS domain; Region: PAS; smart00091
320389011523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
320389011524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
320389011525	metal binding site [ion binding]; metal-binding site
320389011526	active site
320389011527	I-site; other site
320389011528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
320389011529	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
320389011530	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
320389011531	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389011532	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389011533	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
320389011534	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
320389011535	Substrate binding site; other site
320389011536	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
320389011537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389011538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389011539	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
320389011540	putative ADP-binding pocket [chemical binding]; other site
320389011541	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
320389011542	active site
320389011543	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389011544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389011545	Walker A motif; other site
320389011546	ATP binding site [chemical binding]; other site
320389011547	Walker B motif; other site
320389011548	arginine finger; other site
320389011549	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
320389011550	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
320389011551	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
320389011552	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
320389011553	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
320389011554	dimer interface [polypeptide binding]; other site
320389011555	motif 1; other site
320389011556	active site
320389011557	motif 2; other site
320389011558	motif 3; other site
320389011559	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389011560	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389011561	active site
320389011562	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389011563	active site
320389011564	acyl carrier protein; Provisional; Region: PRK07081
320389011565	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
320389011566	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
320389011567	ligand binding site [chemical binding]; other site
320389011568	flexible hinge region; other site
320389011569	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
320389011570	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
320389011571	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
320389011572	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
320389011573	non-specific DNA interactions [nucleotide binding]; other site
320389011574	DNA binding site [nucleotide binding]
320389011575	sequence specific DNA binding site [nucleotide binding]; other site
320389011576	putative cAMP binding site [chemical binding]; other site
320389011577	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
320389011578	Bacterial sugar transferase; Region: Bac_transf; pfam02397
320389011579	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
320389011580	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
320389011581	SLBB domain; Region: SLBB; pfam10531
320389011582	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
320389011583	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
320389011584	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389011585	Transposase domain (DUF772); Region: DUF772; pfam05598
320389011586	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389011587	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389011588	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
320389011589	23S rRNA interface [nucleotide binding]; other site
320389011590	L3 interface [polypeptide binding]; other site
320389011591	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
320389011592	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
320389011593	Cupin; Region: Cupin_6; pfam12852
320389011594	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389011595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389011596	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
320389011597	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
320389011598	C-terminal domain interface [polypeptide binding]; other site
320389011599	GSH binding site (G-site) [chemical binding]; other site
320389011600	dimer interface [polypeptide binding]; other site
320389011601	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
320389011602	N-terminal domain interface [polypeptide binding]; other site
320389011603	dimer interface [polypeptide binding]; other site
320389011604	substrate binding pocket (H-site) [chemical binding]; other site
320389011605	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
320389011606	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
320389011607	C-terminal domain interface [polypeptide binding]; other site
320389011608	GSH binding site (G-site) [chemical binding]; other site
320389011609	dimer interface [polypeptide binding]; other site
320389011610	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
320389011611	N-terminal domain interface [polypeptide binding]; other site
320389011612	putative dimer interface [polypeptide binding]; other site
320389011613	active site
320389011614	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
320389011615	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
320389011616	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
320389011617	active site
320389011618	HIGH motif; other site
320389011619	dimer interface [polypeptide binding]; other site
320389011620	KMSKS motif; other site
320389011621	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389011622	RNA binding surface [nucleotide binding]; other site
320389011623	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
320389011624	putative active site [active]
320389011625	dimerization interface [polypeptide binding]; other site
320389011626	putative tRNAtyr binding site [nucleotide binding]; other site
320389011627	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
320389011628	catalytic core [active]
320389011629	Putative ParB-like nuclease; Region: ParBc_2; cl17538
320389011630	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
320389011631	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
320389011632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389011633	Walker A motif; other site
320389011634	ATP binding site [chemical binding]; other site
320389011635	Walker B motif; other site
320389011636	arginine finger; other site
320389011637	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
320389011638	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
320389011639	RuvA N terminal domain; Region: RuvA_N; pfam01330
320389011640	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
320389011641	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
320389011642	active site
320389011643	putative DNA-binding cleft [nucleotide binding]; other site
320389011644	dimer interface [polypeptide binding]; other site
320389011645	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
320389011646	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
320389011647	purine monophosphate binding site [chemical binding]; other site
320389011648	dimer interface [polypeptide binding]; other site
320389011649	putative catalytic residues [active]
320389011650	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
320389011651	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
320389011652	DNA-binding protein Fis; Provisional; Region: PRK01905
320389011653	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
320389011654	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
320389011655	FMN binding site [chemical binding]; other site
320389011656	active site
320389011657	catalytic residues [active]
320389011658	substrate binding site [chemical binding]; other site
320389011659	hypothetical protein; Provisional; Region: PRK06996
320389011660	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
320389011661	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
320389011662	proline aminopeptidase P II; Provisional; Region: PRK10879
320389011663	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
320389011664	active site
320389011665	putative glutathione S-transferase; Provisional; Region: PRK10357
320389011666	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
320389011667	putative C-terminal domain interface [polypeptide binding]; other site
320389011668	putative GSH binding site (G-site) [chemical binding]; other site
320389011669	putative dimer interface [polypeptide binding]; other site
320389011670	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
320389011671	dimer interface [polypeptide binding]; other site
320389011672	N-terminal domain interface [polypeptide binding]; other site
320389011673	putative substrate binding pocket (H-site) [chemical binding]; other site
320389011674	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
320389011675	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
320389011676	active site
320389011677	FMN binding site [chemical binding]; other site
320389011678	substrate binding site [chemical binding]; other site
320389011679	3Fe-4S cluster binding site [ion binding]; other site
320389011680	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
320389011681	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
320389011682	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
320389011683	nudix motif; other site
320389011684	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
320389011685	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
320389011686	ligand binding site [chemical binding]; other site
320389011687	homodimer interface [polypeptide binding]; other site
320389011688	NAD(P) binding site [chemical binding]; other site
320389011689	trimer interface B [polypeptide binding]; other site
320389011690	trimer interface A [polypeptide binding]; other site
320389011691	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
320389011692	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
320389011693	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
320389011694	Predicted transcriptional regulator [Transcription]; Region: COG2378
320389011695	HTH domain; Region: HTH_11; pfam08279
320389011696	WYL domain; Region: WYL; pfam13280
320389011697	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
320389011698	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
320389011699	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
320389011700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
320389011701	Site-specific recombinase; Region: SpecificRecomb; pfam10136
320389011702	Protein of unknown function (DUF330); Region: DUF330; pfam03886
320389011703	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
320389011704	mce related protein; Region: MCE; pfam02470
320389011705	mce related protein; Region: MCE; pfam02470
320389011706	Paraquat-inducible protein A; Region: PqiA; pfam04403
320389011707	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
320389011708	YceI-like domain; Region: YceI; smart00867
320389011709	Uncharacterized conserved protein [Function unknown]; Region: COG2353
320389011710	citrate-proton symporter; Provisional; Region: PRK15075
320389011711	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
320389011712	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
320389011713	Protein export membrane protein; Region: SecD_SecF; pfam02355
320389011714	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
320389011715	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
320389011716	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
320389011717	Protein export membrane protein; Region: SecD_SecF; cl14618
320389011718	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
320389011719	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
320389011720	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
320389011721	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
320389011722	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
320389011723	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
320389011724	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
320389011725	generic binding surface II; other site
320389011726	ssDNA binding site; other site
320389011727	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389011728	ATP binding site [chemical binding]; other site
320389011729	putative Mg++ binding site [ion binding]; other site
320389011730	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389011731	nucleotide binding region [chemical binding]; other site
320389011732	ATP-binding site [chemical binding]; other site
320389011733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389011734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011735	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
320389011736	dimerization interface [polypeptide binding]; other site
320389011737	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
320389011738	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
320389011739	dimer interface [polypeptide binding]; other site
320389011740	active site
320389011741	heme binding site [chemical binding]; other site
320389011742	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
320389011743	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
320389011744	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
320389011745	dimerization interface [polypeptide binding]; other site
320389011746	DPS ferroxidase diiron center [ion binding]; other site
320389011747	ion pore; other site
320389011748	Predicted transcriptional regulators [Transcription]; Region: COG1733
320389011749	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
320389011750	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
320389011751	UbiA prenyltransferase family; Region: UbiA; pfam01040
320389011752	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
320389011753	active site
320389011754	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
320389011755	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
320389011756	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389011757	DNA-binding site [nucleotide binding]; DNA binding site
320389011758	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
320389011759	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
320389011760	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
320389011761	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
320389011762	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
320389011763	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
320389011764	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389011765	Walker A/P-loop; other site
320389011766	ATP binding site [chemical binding]; other site
320389011767	Q-loop/lid; other site
320389011768	ABC transporter signature motif; other site
320389011769	Walker B; other site
320389011770	D-loop; other site
320389011771	H-loop/switch region; other site
320389011772	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389011773	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
320389011774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389011775	Walker A/P-loop; other site
320389011776	ATP binding site [chemical binding]; other site
320389011777	Q-loop/lid; other site
320389011778	ABC transporter signature motif; other site
320389011779	Walker B; other site
320389011780	D-loop; other site
320389011781	H-loop/switch region; other site
320389011782	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
320389011783	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
320389011784	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
320389011785	active site
320389011786	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
320389011787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389011788	Walker A/P-loop; other site
320389011789	ATP binding site [chemical binding]; other site
320389011790	Q-loop/lid; other site
320389011791	ABC transporter signature motif; other site
320389011792	Walker B; other site
320389011793	D-loop; other site
320389011794	H-loop/switch region; other site
320389011795	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
320389011796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389011797	dimer interface [polypeptide binding]; other site
320389011798	conserved gate region; other site
320389011799	ABC-ATPase subunit interface; other site
320389011800	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
320389011801	pyrroline-5-carboxylate reductase; Region: PLN02688
320389011802	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
320389011803	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389011804	catalytic residue [active]
320389011805	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
320389011806	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
320389011807	Cysteine-rich domain; Region: CCG; pfam02754
320389011808	Cysteine-rich domain; Region: CCG; pfam02754
320389011809	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
320389011810	FAD binding domain; Region: FAD_binding_4; pfam01565
320389011811	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
320389011812	FAD binding domain; Region: FAD_binding_4; pfam01565
320389011813	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
320389011814	FAD binding domain; Region: FAD_binding_4; pfam01565
320389011815	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
320389011816	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
320389011817	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
320389011818	heme-binding site [chemical binding]; other site
320389011819	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
320389011820	FAD binding pocket [chemical binding]; other site
320389011821	FAD binding motif [chemical binding]; other site
320389011822	phosphate binding motif [ion binding]; other site
320389011823	beta-alpha-beta structure motif; other site
320389011824	NAD binding pocket [chemical binding]; other site
320389011825	Heme binding  pocket [chemical binding]; other site
320389011826	Transposase domain (DUF772); Region: DUF772; pfam05598
320389011827	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389011828	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389011829	OsmC-like protein; Region: OsmC; cl00767
320389011830	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
320389011831	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
320389011832	active site
320389011833	substrate binding pocket [chemical binding]; other site
320389011834	dimer interface [polypeptide binding]; other site
320389011835	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
320389011836	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
320389011837	putative active site [active]
320389011838	putative dimer interface [polypeptide binding]; other site
320389011839	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
320389011840	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
320389011841	putative dimer interface [polypeptide binding]; other site
320389011842	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
320389011843	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
320389011844	putative dimer interface [polypeptide binding]; other site
320389011845	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
320389011846	oligomerisation interface [polypeptide binding]; other site
320389011847	mobile loop; other site
320389011848	roof hairpin; other site
320389011849	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
320389011850	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
320389011851	Walker A/P-loop; other site
320389011852	ATP binding site [chemical binding]; other site
320389011853	Q-loop/lid; other site
320389011854	ABC transporter signature motif; other site
320389011855	Walker B; other site
320389011856	D-loop; other site
320389011857	H-loop/switch region; other site
320389011858	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389011859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389011860	dimer interface [polypeptide binding]; other site
320389011861	conserved gate region; other site
320389011862	putative PBP binding loops; other site
320389011863	ABC-ATPase subunit interface; other site
320389011864	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
320389011865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389011866	dimer interface [polypeptide binding]; other site
320389011867	conserved gate region; other site
320389011868	putative PBP binding loops; other site
320389011869	ABC-ATPase subunit interface; other site
320389011870	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
320389011871	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
320389011872	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
320389011873	NAD(P) binding site [chemical binding]; other site
320389011874	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389011875	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011876	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389011877	dimerization interface [polypeptide binding]; other site
320389011878	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
320389011879	adenylosuccinate lyase; Provisional; Region: PRK09285
320389011880	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
320389011881	tetramer interface [polypeptide binding]; other site
320389011882	active site
320389011883	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
320389011884	ATP-binding site [chemical binding]; other site
320389011885	Gluconate-6-phosphate binding site [chemical binding]; other site
320389011886	Shikimate kinase; Region: SKI; pfam01202
320389011887	GntP family permease; Region: GntP_permease; pfam02447
320389011888	fructuronate transporter; Provisional; Region: PRK10034; cl15264
320389011889	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
320389011890	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
320389011891	active site
320389011892	intersubunit interface [polypeptide binding]; other site
320389011893	catalytic residue [active]
320389011894	phosphogluconate dehydratase; Validated; Region: PRK09054
320389011895	6-phosphogluconate dehydratase; Region: edd; TIGR01196
320389011896	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
320389011897	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
320389011898	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
320389011899	putative active site [active]
320389011900	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
320389011901	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
320389011902	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
320389011903	putative catalytic cysteine [active]
320389011904	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
320389011905	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
320389011906	Lipopolysaccharide-assembly; Region: LptE; cl01125
320389011907	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
320389011908	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
320389011909	HIGH motif; other site
320389011910	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
320389011911	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
320389011912	active site
320389011913	KMSKS motif; other site
320389011914	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
320389011915	tRNA binding surface [nucleotide binding]; other site
320389011916	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
320389011917	TolR protein; Region: tolR; TIGR02801
320389011918	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
320389011919	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
320389011920	dihydrodipicolinate reductase; Provisional; Region: PRK00048
320389011921	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
320389011922	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
320389011923	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
320389011924	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
320389011925	ferric uptake regulator; Provisional; Region: fur; PRK09462
320389011926	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
320389011927	metal binding site 2 [ion binding]; metal-binding site
320389011928	putative DNA binding helix; other site
320389011929	metal binding site 1 [ion binding]; metal-binding site
320389011930	dimer interface [polypeptide binding]; other site
320389011931	structural Zn2+ binding site [ion binding]; other site
320389011932	allantoicase; Provisional; Region: PRK13257
320389011933	Allantoicase repeat; Region: Allantoicase; pfam03561
320389011934	Allantoicase repeat; Region: Allantoicase; pfam03561
320389011935	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
320389011936	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
320389011937	HTH-like domain; Region: HTH_21; pfam13276
320389011938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389011939	Integrase core domain; Region: rve; pfam00665
320389011940	Integrase core domain; Region: rve_3; pfam13683
320389011941	Transposase; Region: HTH_Tnp_1; pfam01527
320389011942	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
320389011943	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
320389011944	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
320389011945	Transposase domain (DUF772); Region: DUF772; pfam05598
320389011946	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389011947	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389011948	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
320389011949	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
320389011950	N-acetyl-D-glucosamine binding site [chemical binding]; other site
320389011951	catalytic residue [active]
320389011952	type II secretion system protein D; Region: type_II_gspD; TIGR02517
320389011953	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389011954	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389011955	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389011956	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
320389011957	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389011958	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
320389011959	type II secretion system protein E; Region: type_II_gspE; TIGR02533
320389011960	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
320389011961	Walker A motif; other site
320389011962	ATP binding site [chemical binding]; other site
320389011963	Walker B motif; other site
320389011964	type II secretion system protein F; Region: GspF; TIGR02120
320389011965	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389011966	Ceramidase; Region: Ceramidase; pfam05875
320389011967	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389011968	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
320389011969	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
320389011970	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
320389011971	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
320389011972	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
320389011973	Type II transport protein GspH; Region: GspH; pfam12019
320389011974	type II secretion system protein I; Region: gspI; TIGR01707
320389011975	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
320389011976	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
320389011977	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
320389011978	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
320389011979	GspL periplasmic domain; Region: GspL_C; pfam12693
320389011980	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
320389011981	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
320389011982	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
320389011983	MarR family; Region: MarR_2; cl17246
320389011984	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
320389011985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389011986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389011987	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
320389011988	putative dimerization interface [polypeptide binding]; other site
320389011989	LrgA family; Region: LrgA; pfam03788
320389011990	LrgB-like family; Region: LrgB; cl00596
320389011991	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
320389011992	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
320389011993	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
320389011994	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
320389011995	flagellar motor switch protein; Validated; Region: fliN; PRK05698
320389011996	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
320389011997	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
320389011998	Transposase; Region: HTH_Tnp_1; pfam01527
320389011999	HTH-like domain; Region: HTH_21; pfam13276
320389012000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389012001	Integrase core domain; Region: rve; pfam00665
320389012002	Integrase core domain; Region: rve_3; pfam13683
320389012003	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
320389012004	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
320389012005	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
320389012006	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
320389012007	DNA binding residues [nucleotide binding]
320389012008	putative dimer interface [polypeptide binding]; other site
320389012009	putative metal binding residues [ion binding]; other site
320389012010	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389012011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389012012	S-adenosylmethionine binding site [chemical binding]; other site
320389012013	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
320389012014	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
320389012015	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389012016	membrane-bound complex binding site; other site
320389012017	hinge residues; other site
320389012018	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
320389012019	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
320389012020	Walker A/P-loop; other site
320389012021	ATP binding site [chemical binding]; other site
320389012022	Q-loop/lid; other site
320389012023	ABC transporter signature motif; other site
320389012024	Walker B; other site
320389012025	D-loop; other site
320389012026	H-loop/switch region; other site
320389012027	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
320389012028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389012029	dimer interface [polypeptide binding]; other site
320389012030	conserved gate region; other site
320389012031	putative PBP binding loops; other site
320389012032	ABC-ATPase subunit interface; other site
320389012033	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
320389012034	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389012035	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389012036	dimer interface [polypeptide binding]; other site
320389012037	phosphorylation site [posttranslational modification]
320389012038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389012039	ATP binding site [chemical binding]; other site
320389012040	Mg2+ binding site [ion binding]; other site
320389012041	G-X-G motif; other site
320389012042	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
320389012043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389012044	active site
320389012045	phosphorylation site [posttranslational modification]
320389012046	intermolecular recognition site; other site
320389012047	dimerization interface [polypeptide binding]; other site
320389012048	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389012049	DNA binding site [nucleotide binding]
320389012050	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389012051	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389012052	trimer interface [polypeptide binding]; other site
320389012053	eyelet of channel; other site
320389012054	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
320389012055	DNA methylase; Region: N6_N4_Mtase; pfam01555
320389012056	DNA methylase; Region: N6_N4_Mtase; cl17433
320389012057	Restriction endonuclease [Defense mechanisms]; Region: COG3587
320389012058	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389012059	ATP binding site [chemical binding]; other site
320389012060	putative Mg++ binding site [ion binding]; other site
320389012061	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389012062	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389012063	trimer interface [polypeptide binding]; other site
320389012064	eyelet of channel; other site
320389012065	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
320389012066	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389012067	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
320389012068	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
320389012069	Walker A/P-loop; other site
320389012070	ATP binding site [chemical binding]; other site
320389012071	Q-loop/lid; other site
320389012072	ABC transporter signature motif; other site
320389012073	Walker B; other site
320389012074	D-loop; other site
320389012075	H-loop/switch region; other site
320389012076	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
320389012077	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
320389012078	Walker A/P-loop; other site
320389012079	ATP binding site [chemical binding]; other site
320389012080	Q-loop/lid; other site
320389012081	ABC transporter signature motif; other site
320389012082	Walker B; other site
320389012083	D-loop; other site
320389012084	H-loop/switch region; other site
320389012085	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
320389012086	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
320389012087	TM-ABC transporter signature motif; other site
320389012088	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
320389012089	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389012090	TM-ABC transporter signature motif; other site
320389012091	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
320389012092	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
320389012093	putative ligand binding site [chemical binding]; other site
320389012094	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389012095	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389012096	NAD(P) binding site [chemical binding]; other site
320389012097	catalytic residues [active]
320389012098	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
320389012099	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
320389012100	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
320389012101	classical (c) SDRs; Region: SDR_c; cd05233
320389012102	NAD(P) binding site [chemical binding]; other site
320389012103	active site
320389012104	choline dehydrogenase; Validated; Region: PRK02106
320389012105	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
320389012106	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
320389012107	Predicted transcriptional regulators [Transcription]; Region: COG1695
320389012108	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
320389012109	Predicted membrane protein [Function unknown]; Region: COG4709
320389012110	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
320389012111	Fatty acid desaturase; Region: FA_desaturase; pfam00487
320389012112	putative di-iron ligands [ion binding]; other site
320389012113	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
320389012114	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
320389012115	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
320389012116	conserved cys residue [active]
320389012117	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389012118	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389012119	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389012120	active site
320389012121	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
320389012122	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
320389012123	dimer interface [polypeptide binding]; other site
320389012124	active site
320389012125	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
320389012126	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389012127	substrate binding site [chemical binding]; other site
320389012128	oxyanion hole (OAH) forming residues; other site
320389012129	trimer interface [polypeptide binding]; other site
320389012130	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
320389012131	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389012132	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
320389012133	CoA-transferase family III; Region: CoA_transf_3; pfam02515
320389012134	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
320389012135	HTH-like domain; Region: HTH_21; pfam13276
320389012136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389012137	Integrase core domain; Region: rve; pfam00665
320389012138	Integrase core domain; Region: rve_3; pfam13683
320389012139	Transposase; Region: HTH_Tnp_1; pfam01527
320389012140	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
320389012141	portal vertex protein; Provisional; Region: Q; PHA02536
320389012142	Phage portal protein; Region: Phage_portal; pfam04860
320389012143	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
320389012144	stringent starvation protein A; Provisional; Region: sspA; PRK09481
320389012145	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
320389012146	C-terminal domain interface [polypeptide binding]; other site
320389012147	putative GSH binding site (G-site) [chemical binding]; other site
320389012148	dimer interface [polypeptide binding]; other site
320389012149	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
320389012150	dimer interface [polypeptide binding]; other site
320389012151	N-terminal domain interface [polypeptide binding]; other site
320389012152	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
320389012153	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
320389012154	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
320389012155	Qi binding site; other site
320389012156	intrachain domain interface; other site
320389012157	interchain domain interface [polypeptide binding]; other site
320389012158	heme bH binding site [chemical binding]; other site
320389012159	heme bL binding site [chemical binding]; other site
320389012160	Qo binding site; other site
320389012161	interchain domain interface [polypeptide binding]; other site
320389012162	intrachain domain interface; other site
320389012163	Qi binding site; other site
320389012164	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
320389012165	Qo binding site; other site
320389012166	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
320389012167	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
320389012168	[2Fe-2S] cluster binding site [ion binding]; other site
320389012169	Uncharacterized conserved protein [Function unknown]; Region: COG0327
320389012170	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
320389012171	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
320389012172	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
320389012173	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
320389012174	protein binding site [polypeptide binding]; other site
320389012175	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
320389012176	sec-independent translocase; Provisional; Region: tatB; PRK01919
320389012177	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
320389012178	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
320389012179	nucleotide binding site/active site [active]
320389012180	HIT family signature motif; other site
320389012181	catalytic residue [active]
320389012182	Predicted membrane protein [Function unknown]; Region: COG3671
320389012183	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
320389012184	metal binding site [ion binding]; metal-binding site
320389012185	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
320389012186	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
320389012187	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
320389012188	substrate binding site [chemical binding]; other site
320389012189	glutamase interaction surface [polypeptide binding]; other site
320389012190	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
320389012191	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
320389012192	catalytic residues [active]
320389012193	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
320389012194	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
320389012195	putative active site [active]
320389012196	oxyanion strand; other site
320389012197	catalytic triad [active]
320389012198	MarC family integral membrane protein; Region: MarC; cl00919
320389012199	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
320389012200	putative active site pocket [active]
320389012201	4-fold oligomerization interface [polypeptide binding]; other site
320389012202	metal binding residues [ion binding]; metal-binding site
320389012203	3-fold/trimer interface [polypeptide binding]; other site
320389012204	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
320389012205	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389012206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389012207	homodimer interface [polypeptide binding]; other site
320389012208	catalytic residue [active]
320389012209	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
320389012210	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
320389012211	NAD binding site [chemical binding]; other site
320389012212	dimerization interface [polypeptide binding]; other site
320389012213	product binding site; other site
320389012214	substrate binding site [chemical binding]; other site
320389012215	zinc binding site [ion binding]; other site
320389012216	catalytic residues [active]
320389012217	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
320389012218	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
320389012219	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
320389012220	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
320389012221	hinge; other site
320389012222	active site
320389012223	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
320389012224	ABC-2 type transporter; Region: ABC2_membrane; cl17235
320389012225	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
320389012226	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
320389012227	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
320389012228	Walker A/P-loop; other site
320389012229	ATP binding site [chemical binding]; other site
320389012230	Q-loop/lid; other site
320389012231	ABC transporter signature motif; other site
320389012232	Walker B; other site
320389012233	D-loop; other site
320389012234	H-loop/switch region; other site
320389012235	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
320389012236	anti sigma factor interaction site; other site
320389012237	regulatory phosphorylation site [posttranslational modification]; other site
320389012238	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
320389012239	VacJ like lipoprotein; Region: VacJ; cl01073
320389012240	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
320389012241	mce related protein; Region: MCE; pfam02470
320389012242	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
320389012243	Permease; Region: Permease; pfam02405
320389012244	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
320389012245	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
320389012246	Walker A/P-loop; other site
320389012247	ATP binding site [chemical binding]; other site
320389012248	Q-loop/lid; other site
320389012249	ABC transporter signature motif; other site
320389012250	Walker B; other site
320389012251	D-loop; other site
320389012252	H-loop/switch region; other site
320389012253	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
320389012254	thiamine phosphate binding site [chemical binding]; other site
320389012255	active site
320389012256	pyrophosphate binding site [ion binding]; other site
320389012257	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
320389012258	ThiS interaction site; other site
320389012259	putative active site [active]
320389012260	tetramer interface [polypeptide binding]; other site
320389012261	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
320389012262	thiS-thiF/thiG interaction site; other site
320389012263	FAD dependent oxidoreductase; Region: DAO; pfam01266
320389012264	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
320389012265	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
320389012266	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
320389012267	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
320389012268	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
320389012269	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
320389012270	amino acid carrier protein; Region: agcS; TIGR00835
320389012271	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
320389012272	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389012273	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
320389012274	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
320389012275	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
320389012276	active site
320389012277	dimer interface [polypeptide binding]; other site
320389012278	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
320389012279	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
320389012280	active site
320389012281	FMN binding site [chemical binding]; other site
320389012282	substrate binding site [chemical binding]; other site
320389012283	3Fe-4S cluster binding site [ion binding]; other site
320389012284	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
320389012285	domain interface; other site
320389012286	Transposase IS200 like; Region: Y1_Tnp; cl00848
320389012287	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
320389012288	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
320389012289	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
320389012290	active site
320389012291	catalytic site [active]
320389012292	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
320389012293	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
320389012294	Walker A/P-loop; other site
320389012295	ATP binding site [chemical binding]; other site
320389012296	Q-loop/lid; other site
320389012297	ABC transporter signature motif; other site
320389012298	Walker B; other site
320389012299	D-loop; other site
320389012300	H-loop/switch region; other site
320389012301	TOBE domain; Region: TOBE_2; pfam08402
320389012302	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
320389012303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389012304	dimer interface [polypeptide binding]; other site
320389012305	conserved gate region; other site
320389012306	putative PBP binding loops; other site
320389012307	ABC-ATPase subunit interface; other site
320389012308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389012309	dimer interface [polypeptide binding]; other site
320389012310	conserved gate region; other site
320389012311	putative PBP binding loops; other site
320389012312	ABC-ATPase subunit interface; other site
320389012313	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
320389012314	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
320389012315	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
320389012316	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
320389012317	Zn2+ binding site [ion binding]; other site
320389012318	Mg2+ binding site [ion binding]; other site
320389012319	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
320389012320	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
320389012321	active site
320389012322	dimer interface [polypeptide binding]; other site
320389012323	metal binding site [ion binding]; metal-binding site
320389012324	shikimate kinase; Reviewed; Region: aroK; PRK00131
320389012325	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
320389012326	ADP binding site [chemical binding]; other site
320389012327	magnesium binding site [ion binding]; other site
320389012328	putative shikimate binding site; other site
320389012329	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
320389012330	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
320389012331	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
320389012332	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
320389012333	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
320389012334	Transglycosylase; Region: Transgly; pfam00912
320389012335	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
320389012336	Transposase domain (DUF772); Region: DUF772; pfam05598
320389012337	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389012338	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389012339	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
320389012340	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
320389012341	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
320389012342	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389012343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389012344	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
320389012345	putative effector binding pocket; other site
320389012346	dimerization interface [polypeptide binding]; other site
320389012347	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
320389012348	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389012349	substrate binding site [chemical binding]; other site
320389012350	oxyanion hole (OAH) forming residues; other site
320389012351	trimer interface [polypeptide binding]; other site
320389012352	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
320389012353	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389012354	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
320389012355	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
320389012356	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389012357	active site
320389012358	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
320389012359	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
320389012360	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
320389012361	active site
320389012362	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
320389012363	CoA-transferase family III; Region: CoA_transf_3; pfam02515
320389012364	Protein of unknown function, DUF485; Region: DUF485; pfam04341
320389012365	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
320389012366	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
320389012367	Na binding site [ion binding]; other site
320389012368	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
320389012369	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
320389012370	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
320389012371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389012372	active site
320389012373	phosphorylation site [posttranslational modification]
320389012374	intermolecular recognition site; other site
320389012375	dimerization interface [polypeptide binding]; other site
320389012376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389012377	Walker A motif; other site
320389012378	ATP binding site [chemical binding]; other site
320389012379	Walker B motif; other site
320389012380	arginine finger; other site
320389012381	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389012382	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
320389012383	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389012384	catalytic residues [active]
320389012385	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
320389012386	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
320389012387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
320389012388	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
320389012389	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
320389012390	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
320389012391	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
320389012392	Membrane fusogenic activity; Region: BMFP; pfam04380
320389012393	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
320389012394	Nitrogen regulatory protein P-II; Region: P-II; smart00938
320389012395	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
320389012396	Transposase domain (DUF772); Region: DUF772; pfam05598
320389012397	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389012398	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389012399	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
320389012400	Glutamate-cysteine ligase; Region: GshA; pfam08886
320389012401	glutathione synthetase; Provisional; Region: PRK05246
320389012402	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
320389012403	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
320389012404	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
320389012405	active pocket/dimerization site; other site
320389012406	active site
320389012407	phosphorylation site [posttranslational modification]
320389012408	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
320389012409	dimerization domain swap beta strand [polypeptide binding]; other site
320389012410	regulatory protein interface [polypeptide binding]; other site
320389012411	active site
320389012412	regulatory phosphorylation site [posttranslational modification]; other site
320389012413	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
320389012414	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
320389012415	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
320389012416	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
320389012417	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
320389012418	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
320389012419	ATP binding site [chemical binding]; other site
320389012420	substrate interface [chemical binding]; other site
320389012421	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
320389012422	C-terminal peptidase (prc); Region: prc; TIGR00225
320389012423	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
320389012424	protein binding site [polypeptide binding]; other site
320389012425	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
320389012426	Catalytic dyad [active]
320389012427	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
320389012428	catalytic core [active]
320389012429	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
320389012430	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
320389012431	active site residue [active]
320389012432	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
320389012433	GSH binding site [chemical binding]; other site
320389012434	catalytic residues [active]
320389012435	preprotein translocase subunit SecB; Validated; Region: PRK05751
320389012436	SecA binding site; other site
320389012437	Preprotein binding site; other site
320389012438	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
320389012439	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
320389012440	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
320389012441	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
320389012442	putative ADP-ribose binding site [chemical binding]; other site
320389012443	putative active site [active]
320389012444	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
320389012445	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
320389012446	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389012447	active site
320389012448	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
320389012449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389012450	S-adenosylmethionine binding site [chemical binding]; other site
320389012451	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
320389012452	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
320389012453	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
320389012454	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
320389012455	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
320389012456	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
320389012457	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
320389012458	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389012459	ligand binding site [chemical binding]; other site
320389012460	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
320389012461	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
320389012462	Subunit I/III interface [polypeptide binding]; other site
320389012463	D-pathway; other site
320389012464	Subunit I/VIIc interface [polypeptide binding]; other site
320389012465	Subunit I/IV interface [polypeptide binding]; other site
320389012466	Subunit I/II interface [polypeptide binding]; other site
320389012467	Low-spin heme (heme a) binding site [chemical binding]; other site
320389012468	Subunit I/VIIa interface [polypeptide binding]; other site
320389012469	Subunit I/VIa interface [polypeptide binding]; other site
320389012470	Dimer interface; other site
320389012471	Putative water exit pathway; other site
320389012472	Binuclear center (heme a3/CuB) [ion binding]; other site
320389012473	K-pathway; other site
320389012474	Subunit I/Vb interface [polypeptide binding]; other site
320389012475	Putative proton exit pathway; other site
320389012476	Subunit I/VIb interface; other site
320389012477	Subunit I/VIc interface [polypeptide binding]; other site
320389012478	Electron transfer pathway; other site
320389012479	Subunit I/VIIIb interface [polypeptide binding]; other site
320389012480	Subunit I/VIIb interface [polypeptide binding]; other site
320389012481	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
320389012482	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
320389012483	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
320389012484	Subunit III/VIIa interface [polypeptide binding]; other site
320389012485	Phospholipid binding site [chemical binding]; other site
320389012486	Subunit I/III interface [polypeptide binding]; other site
320389012487	Subunit III/VIb interface [polypeptide binding]; other site
320389012488	Subunit III/VIa interface; other site
320389012489	Subunit III/Vb interface [polypeptide binding]; other site
320389012490	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
320389012491	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
320389012492	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
320389012493	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
320389012494	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
320389012495	UbiA prenyltransferase family; Region: UbiA; pfam01040
320389012496	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
320389012497	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
320389012498	Cu(I) binding site [ion binding]; other site
320389012499	YCII-related domain; Region: YCII; cl00999
320389012500	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
320389012501	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
320389012502	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
320389012503	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389012504	dimer interface [polypeptide binding]; other site
320389012505	putative CheW interface [polypeptide binding]; other site
320389012506	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
320389012507	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
320389012508	Transposase domain (DUF772); Region: DUF772; pfam05598
320389012509	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389012510	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389012511	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389012512	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389012513	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
320389012514	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
320389012515	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
320389012516	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
320389012517	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
320389012518	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
320389012519	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
320389012520	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
320389012521	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
320389012522	active site
320389012523	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
320389012524	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
320389012525	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
320389012526	active site turn [active]
320389012527	phosphorylation site [posttranslational modification]
320389012528	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
320389012529	HPr interaction site; other site
320389012530	glycerol kinase (GK) interaction site [polypeptide binding]; other site
320389012531	active site
320389012532	phosphorylation site [posttranslational modification]
320389012533	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
320389012534	dimerization domain swap beta strand [polypeptide binding]; other site
320389012535	regulatory protein interface [polypeptide binding]; other site
320389012536	active site
320389012537	regulatory phosphorylation site [posttranslational modification]; other site
320389012538	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
320389012539	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
320389012540	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
320389012541	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
320389012542	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
320389012543	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
320389012544	dimer interface [polypeptide binding]; other site
320389012545	active site
320389012546	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
320389012547	dimer interface [polypeptide binding]; other site
320389012548	active site
320389012549	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
320389012550	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
320389012551	active site
320389012552	dimer interface [polypeptide binding]; other site
320389012553	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
320389012554	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389012555	DNA-binding site [nucleotide binding]; DNA binding site
320389012556	UTRA domain; Region: UTRA; pfam07702
320389012557	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
320389012558	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389012559	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
320389012560	dimerization interface [polypeptide binding]; other site
320389012561	substrate binding pocket [chemical binding]; other site
320389012562	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
320389012563	acyl-CoA synthetase; Validated; Region: PRK09192
320389012564	acyl-activating enzyme (AAE) consensus motif; other site
320389012565	active site
320389012566	Phosphopantetheine attachment site; Region: PP-binding; cl09936
320389012567	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
320389012568	dinuclear metal binding motif [ion binding]; other site
320389012569	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
320389012570	active site
320389012571	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810
320389012572	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
320389012573	dimer interface [polypeptide binding]; other site
320389012574	active site
320389012575	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389012576	catalytic residues [active]
320389012577	substrate binding site [chemical binding]; other site
320389012578	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
320389012579	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389012580	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389012581	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389012582	acyl-activating enzyme (AAE) consensus motif; other site
320389012583	acyl-activating enzyme (AAE) consensus motif; other site
320389012584	AMP binding site [chemical binding]; other site
320389012585	active site
320389012586	CoA binding site [chemical binding]; other site
320389012587	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
320389012588	active site
320389012589	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
320389012590	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
320389012591	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389012592	active site
320389012593	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
320389012594	Citrate synthase; Region: Citrate_synt; pfam00285
320389012595	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
320389012596	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
320389012597	citrylCoA binding site [chemical binding]; other site
320389012598	oxalacetate binding site [chemical binding]; other site
320389012599	coenzyme A binding site [chemical binding]; other site
320389012600	catalytic triad [active]
320389012601	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389012602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389012603	S-adenosylmethionine binding site [chemical binding]; other site
320389012604	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
320389012605	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
320389012606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389012607	Walker A/P-loop; other site
320389012608	ATP binding site [chemical binding]; other site
320389012609	Q-loop/lid; other site
320389012610	ABC transporter signature motif; other site
320389012611	Walker B; other site
320389012612	D-loop; other site
320389012613	H-loop/switch region; other site
320389012614	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
320389012615	ABC-2 type transporter; Region: ABC2_membrane; cl17235
320389012616	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
320389012617	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
320389012618	inhibitor-cofactor binding pocket; inhibition site
320389012619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389012620	catalytic residue [active]
320389012621	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
320389012622	Fatty acid desaturase; Region: FA_desaturase; pfam00487
320389012623	putative di-iron ligands [ion binding]; other site
320389012624	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
320389012625	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
320389012626	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
320389012627	putative active site [active]
320389012628	putative PHP Thumb interface [polypeptide binding]; other site
320389012629	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
320389012630	generic binding surface II; other site
320389012631	generic binding surface I; other site
320389012632	DNA Polymerase Y-family; Region: PolY_like; cd03468
320389012633	active site
320389012634	DNA binding site [nucleotide binding]
320389012635	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
320389012636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
320389012637	Walker A/P-loop; other site
320389012638	ATP binding site [chemical binding]; other site
320389012639	Q-loop/lid; other site
320389012640	ABC transporter signature motif; other site
320389012641	Walker B; other site
320389012642	D-loop; other site
320389012643	H-loop/switch region; other site
320389012644	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389012645	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
320389012646	TM-ABC transporter signature motif; other site
320389012647	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
320389012648	zinc binding site [ion binding]; other site
320389012649	putative ligand binding site [chemical binding]; other site
320389012650	Transposase domain (DUF772); Region: DUF772; pfam05598
320389012651	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389012652	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389012653	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
320389012654	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
320389012655	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389012656	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389012657	DNA binding residues [nucleotide binding]
320389012658	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
320389012659	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
320389012660	SnoaL-like domain; Region: SnoaL_3; pfam13474
320389012661	2-isopropylmalate synthase; Validated; Region: PRK03739
320389012662	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
320389012663	active site
320389012664	catalytic residues [active]
320389012665	metal binding site [ion binding]; metal-binding site
320389012666	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389012667	Coenzyme A binding pocket [chemical binding]; other site
320389012668	glycosyl transferase family protein; Provisional; Region: PRK08136
320389012669	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
320389012670	Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926
320389012671	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
320389012672	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
320389012673	molybdopterin cofactor binding site; other site
320389012674	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
320389012675	molybdopterin cofactor binding site; other site
320389012676	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
320389012677	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
320389012678	[2Fe-2S] cluster binding site [ion binding]; other site
320389012679	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
320389012680	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
320389012681	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
320389012682	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
320389012683	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
320389012684	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
320389012685	maleylacetoacetate isomerase; Region: maiA; TIGR01262
320389012686	C-terminal domain interface [polypeptide binding]; other site
320389012687	GSH binding site (G-site) [chemical binding]; other site
320389012688	putative dimer interface [polypeptide binding]; other site
320389012689	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
320389012690	dimer interface [polypeptide binding]; other site
320389012691	N-terminal domain interface [polypeptide binding]; other site
320389012692	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
320389012693	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
320389012694	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
320389012695	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
320389012696	P loop; other site
320389012697	GTP binding site [chemical binding]; other site
320389012698	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
320389012699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389012700	S-adenosylmethionine binding site [chemical binding]; other site
320389012701	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
320389012702	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
320389012703	active site
320389012704	(T/H)XGH motif; other site
320389012705	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
320389012706	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
320389012707	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389012708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389012709	homodimer interface [polypeptide binding]; other site
320389012710	catalytic residue [active]
320389012711	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
320389012712	putative active site [active]
320389012713	catalytic residue [active]
320389012714	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
320389012715	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
320389012716	5S rRNA interface [nucleotide binding]; other site
320389012717	CTC domain interface [polypeptide binding]; other site
320389012718	L16 interface [polypeptide binding]; other site
320389012719	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
320389012720	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
320389012721	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389012722	active site
320389012723	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
320389012724	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
320389012725	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
320389012726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
320389012727	binding surface
320389012728	TPR motif; other site
320389012729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389012730	binding surface
320389012731	TPR motif; other site
320389012732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389012733	binding surface
320389012734	TPR motif; other site
320389012735	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
320389012736	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
320389012737	DNA binding site [nucleotide binding]
320389012738	catalytic residue [active]
320389012739	H2TH interface [polypeptide binding]; other site
320389012740	putative catalytic residues [active]
320389012741	turnover-facilitating residue; other site
320389012742	intercalation triad [nucleotide binding]; other site
320389012743	8OG recognition residue [nucleotide binding]; other site
320389012744	putative reading head residues; other site
320389012745	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
320389012746	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
320389012747	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
320389012748	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
320389012749	minor groove reading motif; other site
320389012750	helix-hairpin-helix signature motif; other site
320389012751	active site
320389012752	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
320389012753	DNA binding and oxoG recognition site [nucleotide binding]
320389012754	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
320389012755	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
320389012756	HPr kinase/phosphorylase; Provisional; Region: PRK05428
320389012757	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
320389012758	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
320389012759	Hpr binding site; other site
320389012760	active site
320389012761	homohexamer subunit interaction site [polypeptide binding]; other site
320389012762	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
320389012763	active site
320389012764	phosphorylation site [posttranslational modification]
320389012765	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
320389012766	30S subunit binding site; other site
320389012767	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
320389012768	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
320389012769	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
320389012770	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
320389012771	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
320389012772	Walker A/P-loop; other site
320389012773	ATP binding site [chemical binding]; other site
320389012774	Q-loop/lid; other site
320389012775	ABC transporter signature motif; other site
320389012776	Walker B; other site
320389012777	D-loop; other site
320389012778	H-loop/switch region; other site
320389012779	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
320389012780	OstA-like protein; Region: OstA; pfam03968
320389012781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
320389012782	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
320389012783	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
320389012784	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389012785	active site
320389012786	motif I; other site
320389012787	motif II; other site
320389012788	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
320389012789	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
320389012790	putative active site [active]
320389012791	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
320389012792	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
320389012793	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
320389012794	TrkA-N domain; Region: TrkA_N; pfam02254
320389012795	TrkA-C domain; Region: TrkA_C; pfam02080
320389012796	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389012797	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
320389012798	nudix motif; other site
320389012799	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
320389012800	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
320389012801	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
320389012802	putative active site [active]
320389012803	putative substrate binding site [chemical binding]; other site
320389012804	putative cosubstrate binding site; other site
320389012805	catalytic site [active]
320389012806	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
320389012807	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
320389012808	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
320389012809	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
320389012810	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
320389012811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389012812	Major Facilitator Superfamily; Region: MFS_1; pfam07690
320389012813	putative substrate translocation pore; other site
320389012814	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
320389012815	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
320389012816	dimer interface [polypeptide binding]; other site
320389012817	ssDNA binding site [nucleotide binding]; other site
320389012818	tetramer (dimer of dimers) interface [polypeptide binding]; other site
320389012819	Transposase; Region: HTH_Tnp_1; pfam01527
320389012820	HTH-like domain; Region: HTH_21; pfam13276
320389012821	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389012822	Integrase core domain; Region: rve; pfam00665
320389012823	Integrase core domain; Region: rve_3; pfam13683
320389012824	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
320389012825	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
320389012826	dimerization interface [polypeptide binding]; other site
320389012827	ligand binding site [chemical binding]; other site
320389012828	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
320389012829	H-NS histone family; Region: Histone_HNS; pfam00816
320389012830	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389012831	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
320389012832	Cation efflux family; Region: Cation_efflux; pfam01545
320389012833	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389012834	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389012835	putative DNA binding site [nucleotide binding]; other site
320389012836	putative Zn2+ binding site [ion binding]; other site
320389012837	AsnC family; Region: AsnC_trans_reg; pfam01037
320389012838	active site
320389012839	catalytic site [active]
320389012840	substrate binding site [chemical binding]; other site
320389012841	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
320389012842	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
320389012843	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
320389012844	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
320389012845	Transposase domain (DUF772); Region: DUF772; pfam05598
320389012846	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389012847	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389012848	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
320389012849	IHF dimer interface [polypeptide binding]; other site
320389012850	IHF - DNA interface [nucleotide binding]; other site
320389012851	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
320389012852	Uncharacterized conserved protein [Function unknown]; Region: COG4121
320389012853	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
320389012854	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
320389012855	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
320389012856	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
320389012857	Transcriptional regulators [Transcription]; Region: MarR; COG1846
320389012858	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389012859	dimerization interface [polypeptide binding]; other site
320389012860	putative DNA binding site [nucleotide binding]; other site
320389012861	putative Zn2+ binding site [ion binding]; other site
320389012862	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
320389012863	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
320389012864	catalytic triad [active]
320389012865	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
320389012866	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
320389012867	active site
320389012868	FMN binding site [chemical binding]; other site
320389012869	substrate binding site [chemical binding]; other site
320389012870	homotetramer interface [polypeptide binding]; other site
320389012871	catalytic residue [active]
320389012872	Proteins containing SET domain [General function prediction only]; Region: COG2940
320389012873	SET domain; Region: SET; pfam00856
320389012874	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
320389012875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389012876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
320389012877	dimer interface [polypeptide binding]; other site
320389012878	phosphorylation site [posttranslational modification]
320389012879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389012880	ATP binding site [chemical binding]; other site
320389012881	Mg2+ binding site [ion binding]; other site
320389012882	G-X-G motif; other site
320389012883	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
320389012884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389012885	active site
320389012886	phosphorylation site [posttranslational modification]
320389012887	intermolecular recognition site; other site
320389012888	dimerization interface [polypeptide binding]; other site
320389012889	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
320389012890	DNA binding site [nucleotide binding]
320389012891	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
320389012892	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
320389012893	aromatic arch; other site
320389012894	DCoH dimer interaction site [polypeptide binding]; other site
320389012895	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
320389012896	DCoH tetramer interaction site [polypeptide binding]; other site
320389012897	substrate binding site [chemical binding]; other site
320389012898	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
320389012899	cofactor binding site; other site
320389012900	metal binding site [ion binding]; metal-binding site
320389012901	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389012902	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
320389012903	putative DNA binding site [nucleotide binding]; other site
320389012904	putative Zn2+ binding site [ion binding]; other site
320389012905	AsnC family; Region: AsnC_trans_reg; pfam01037
320389012906	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
320389012907	putative active site [active]
320389012908	putative metal binding residues [ion binding]; other site
320389012909	signature motif; other site
320389012910	putative triphosphate binding site [ion binding]; other site
320389012911	dimer interface [polypeptide binding]; other site
320389012912	Transcriptional regulator [Transcription]; Region: LysR; COG0583
320389012913	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389012914	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
320389012915	dimerization interface [polypeptide binding]; other site
320389012916	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
320389012917	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
320389012918	tetrameric interface [polypeptide binding]; other site
320389012919	NAD binding site [chemical binding]; other site
320389012920	catalytic residues [active]
320389012921	choline dehydrogenase; Validated; Region: PRK02106
320389012922	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
320389012923	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
320389012924	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
320389012925	Walker A/P-loop; other site
320389012926	ATP binding site [chemical binding]; other site
320389012927	Q-loop/lid; other site
320389012928	ABC transporter signature motif; other site
320389012929	Walker B; other site
320389012930	D-loop; other site
320389012931	H-loop/switch region; other site
320389012932	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
320389012933	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
320389012934	Walker A/P-loop; other site
320389012935	ATP binding site [chemical binding]; other site
320389012936	Q-loop/lid; other site
320389012937	ABC transporter signature motif; other site
320389012938	Walker B; other site
320389012939	D-loop; other site
320389012940	H-loop/switch region; other site
320389012941	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389012942	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
320389012943	TM-ABC transporter signature motif; other site
320389012944	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
320389012945	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
320389012946	TM-ABC transporter signature motif; other site
320389012947	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
320389012948	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
320389012949	putative ligand binding site [chemical binding]; other site
320389012950	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
320389012951	TM-ABC transporter signature motif; other site
320389012952	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
320389012953	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
320389012954	TM-ABC transporter signature motif; other site
320389012955	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
320389012956	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
320389012957	Walker A/P-loop; other site
320389012958	ATP binding site [chemical binding]; other site
320389012959	Q-loop/lid; other site
320389012960	ABC transporter signature motif; other site
320389012961	Walker B; other site
320389012962	D-loop; other site
320389012963	H-loop/switch region; other site
320389012964	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
320389012965	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
320389012966	Walker A/P-loop; other site
320389012967	ATP binding site [chemical binding]; other site
320389012968	Q-loop/lid; other site
320389012969	ABC transporter signature motif; other site
320389012970	Walker B; other site
320389012971	D-loop; other site
320389012972	H-loop/switch region; other site
320389012973	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
320389012974	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
320389012975	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
320389012976	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
320389012977	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
320389012978	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
320389012979	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
320389012980	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
320389012981	P-loop; other site
320389012982	Magnesium ion binding site [ion binding]; other site
320389012983	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
320389012984	Magnesium ion binding site [ion binding]; other site
320389012985	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
320389012986	ParB-like nuclease domain; Region: ParBc; pfam02195
320389012987	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
320389012988	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
320389012989	transmembrane helices; other site
320389012990	ATP synthase I chain; Region: ATP_synt_I; cl09170
320389012991	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
320389012992	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
320389012993	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
320389012994	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
320389012995	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
320389012996	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
320389012997	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
320389012998	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
320389012999	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
320389013000	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
320389013001	beta subunit interaction interface [polypeptide binding]; other site
320389013002	Walker A motif; other site
320389013003	ATP binding site [chemical binding]; other site
320389013004	Walker B motif; other site
320389013005	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
320389013006	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
320389013007	core domain interface [polypeptide binding]; other site
320389013008	delta subunit interface [polypeptide binding]; other site
320389013009	epsilon subunit interface [polypeptide binding]; other site
320389013010	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
320389013011	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
320389013012	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
320389013013	alpha subunit interaction interface [polypeptide binding]; other site
320389013014	Walker A motif; other site
320389013015	ATP binding site [chemical binding]; other site
320389013016	Walker B motif; other site
320389013017	inhibitor binding site; inhibition site
320389013018	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
320389013019	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
320389013020	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
320389013021	gamma subunit interface [polypeptide binding]; other site
320389013022	epsilon subunit interface [polypeptide binding]; other site
320389013023	LBP interface [polypeptide binding]; other site
320389013024	Transposase domain (DUF772); Region: DUF772; pfam05598
320389013025	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389013026	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389013027	AMP-binding domain protein; Validated; Region: PRK08315
320389013028	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389013029	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
320389013030	acyl-activating enzyme (AAE) consensus motif; other site
320389013031	putative AMP binding site [chemical binding]; other site
320389013032	putative active site [active]
320389013033	putative CoA binding site [chemical binding]; other site
320389013034	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389013035	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
320389013036	substrate binding pocket [chemical binding]; other site
320389013037	membrane-bound complex binding site; other site
320389013038	hinge residues; other site
320389013039	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
320389013040	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
320389013041	substrate binding site [chemical binding]; other site
320389013042	active site
320389013043	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
320389013044	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389013045	ATP binding site [chemical binding]; other site
320389013046	putative Mg++ binding site [ion binding]; other site
320389013047	nucleotide binding region [chemical binding]; other site
320389013048	helicase superfamily c-terminal domain; Region: HELICc; smart00490
320389013049	ATP-binding site [chemical binding]; other site
320389013050	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
320389013051	Predicted transcriptional regulator [Transcription]; Region: COG3905
320389013052	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
320389013053	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
320389013054	Glutamate binding site [chemical binding]; other site
320389013055	NAD binding site [chemical binding]; other site
320389013056	catalytic residues [active]
320389013057	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
320389013058	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
320389013059	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
320389013060	dimerization interface [polypeptide binding]; other site
320389013061	ligand binding site [chemical binding]; other site
320389013062	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
320389013063	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
320389013064	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
320389013065	acyl-activating enzyme (AAE) consensus motif; other site
320389013066	acyl-activating enzyme (AAE) consensus motif; other site
320389013067	putative AMP binding site [chemical binding]; other site
320389013068	putative active site [active]
320389013069	putative CoA binding site [chemical binding]; other site
320389013070	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
320389013071	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
320389013072	active site
320389013073	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389013074	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389013075	putative aminotransferase; Provisional; Region: PRK12414
320389013076	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
320389013077	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389013078	homodimer interface [polypeptide binding]; other site
320389013079	catalytic residue [active]
320389013080	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
320389013081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
320389013082	substrate binding pocket [chemical binding]; other site
320389013083	membrane-bound complex binding site; other site
320389013084	hinge residues; other site
320389013085	Predicted transcriptional regulators [Transcription]; Region: COG1695
320389013086	Transcriptional regulator PadR-like family; Region: PadR; cl17335
320389013087	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
320389013088	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
320389013089	DNA binding residues [nucleotide binding]
320389013090	dimer interface [polypeptide binding]; other site
320389013091	putative metal binding site [ion binding]; other site
320389013092	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
320389013093	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
320389013094	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
320389013095	Soluble P-type ATPase [General function prediction only]; Region: COG4087
320389013096	Double zinc ribbon; Region: DZR; pfam12773
320389013097	Conserved TM helix; Region: TM_helix; pfam05552
320389013098	Conserved TM helix; Region: TM_helix; pfam05552
320389013099	Conserved TM helix; Region: TM_helix; pfam05552
320389013100	ethanolamine permease; Region: 2A0305; TIGR00908
320389013101	Transposase domain (DUF772); Region: DUF772; pfam05598
320389013102	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389013103	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389013104	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
320389013105	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
320389013106	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
320389013107	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
320389013108	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
320389013109	NAD(P) binding site [chemical binding]; other site
320389013110	catalytic residues [active]
320389013111	Helix-turn-helix domain; Region: HTH_18; pfam12833
320389013112	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
320389013113	thiamine pyrophosphate protein; Validated; Region: PRK08199
320389013114	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
320389013115	PYR/PP interface [polypeptide binding]; other site
320389013116	dimer interface [polypeptide binding]; other site
320389013117	TPP binding site [chemical binding]; other site
320389013118	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
320389013119	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
320389013120	TPP-binding site [chemical binding]; other site
320389013121	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
320389013122	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
320389013123	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
320389013124	Alginate lyase; Region: Alginate_lyase; pfam05426
320389013125	glycine dehydrogenase; Provisional; Region: PRK05367
320389013126	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
320389013127	tetramer interface [polypeptide binding]; other site
320389013128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389013129	catalytic residue [active]
320389013130	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
320389013131	tetramer interface [polypeptide binding]; other site
320389013132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389013133	catalytic residue [active]
320389013134	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
320389013135	lipoyl attachment site [posttranslational modification]; other site
320389013136	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
320389013137	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
320389013138	putative oxidoreductase; Provisional; Region: PRK11579
320389013139	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
320389013140	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
320389013141	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
320389013142	oxyanion hole [active]
320389013143	active site
320389013144	catalytic triad [active]
320389013145	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
320389013146	Part of AAA domain; Region: AAA_19; pfam13245
320389013147	Family description; Region: UvrD_C_2; pfam13538
320389013148	Cytochrome c; Region: Cytochrom_C; cl11414
320389013149	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
320389013150	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
320389013151	Int/Topo IB signature motif; other site
320389013152	HTH-like domain; Region: HTH_21; pfam13276
320389013153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389013154	Integrase core domain; Region: rve; pfam00665
320389013155	Integrase core domain; Region: rve_3; pfam13683
320389013156	Transposase; Region: HTH_Tnp_1; pfam01527
320389013157	Chitin binding domain; Region: Chitin_bind_3; pfam03067
320389013158	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
320389013159	FAD binding domain; Region: FAD_binding_4; pfam01565
320389013160	Berberine and berberine like; Region: BBE; pfam08031
320389013161	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
320389013162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
320389013163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
320389013164	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
320389013165	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
320389013166	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389013167	Methyltransferase domain; Region: Methyltransf_23; pfam13489
320389013168	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
320389013169	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
320389013170	[2Fe-2S] cluster binding site [ion binding]; other site
320389013171	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
320389013172	alpha subunit interface [polypeptide binding]; other site
320389013173	active site
320389013174	substrate binding site [chemical binding]; other site
320389013175	Fe binding site [ion binding]; other site
320389013176	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
320389013177	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
320389013178	putative trimer interface [polypeptide binding]; other site
320389013179	putative CoA binding site [chemical binding]; other site
320389013180	short chain dehydrogenase; Provisional; Region: PRK06500
320389013181	classical (c) SDRs; Region: SDR_c; cd05233
320389013182	NAD(P) binding site [chemical binding]; other site
320389013183	active site
320389013184	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
320389013185	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
320389013186	dimer interface [polypeptide binding]; other site
320389013187	active site
320389013188	CoA binding pocket [chemical binding]; other site
320389013189	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
320389013190	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
320389013191	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
320389013192	dimer interface [polypeptide binding]; other site
320389013193	active site
320389013194	CoA binding pocket [chemical binding]; other site
320389013195	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
320389013196	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
320389013197	inhibitor-cofactor binding pocket; inhibition site
320389013198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389013199	catalytic residue [active]
320389013200	Tetratricopeptide repeat; Region: TPR_16; pfam13432
320389013201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389013202	TPR motif; other site
320389013203	binding surface
320389013204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389013205	binding surface
320389013206	TPR motif; other site
320389013207	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
320389013208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
320389013209	TPR motif; other site
320389013210	binding surface
320389013211	flagellar capping protein; Reviewed; Region: fliD; PRK08032
320389013212	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
320389013213	flagellin; Reviewed; Region: PRK08869
320389013214	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
320389013215	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
320389013216	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
320389013217	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
320389013218	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
320389013219	putative hydrolase; Provisional; Region: PRK10976
320389013220	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389013221	active site
320389013222	motif I; other site
320389013223	motif II; other site
320389013224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
320389013225	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
320389013226	amphipathic channel; other site
320389013227	Asn-Pro-Ala signature motifs; other site
320389013228	H-NS histone family; Region: Histone_HNS; pfam00816
320389013229	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
320389013230	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
320389013231	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
320389013232	putative ADP-binding pocket [chemical binding]; other site
320389013233	transcriptional activator FlhD; Provisional; Region: PRK02909
320389013234	transcriptional activator FlhC; Provisional; Region: PRK12722
320389013235	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
320389013236	flagellar motor protein MotA; Validated; Region: PRK09110
320389013237	Response regulator receiver domain; Region: Response_reg; pfam00072
320389013238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389013239	active site
320389013240	phosphorylation site [posttranslational modification]
320389013241	intermolecular recognition site; other site
320389013242	dimerization interface [polypeptide binding]; other site
320389013243	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
320389013244	putative binding surface; other site
320389013245	active site
320389013246	CheY binding; Region: CheY-binding; pfam09078
320389013247	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
320389013248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389013249	ATP binding site [chemical binding]; other site
320389013250	Mg2+ binding site [ion binding]; other site
320389013251	G-X-G motif; other site
320389013252	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
320389013253	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
320389013254	putative CheA interaction surface; other site
320389013255	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
320389013256	dimer interface [polypeptide binding]; other site
320389013257	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
320389013258	dimerization interface [polypeptide binding]; other site
320389013259	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
320389013260	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
320389013261	dimer interface [polypeptide binding]; other site
320389013262	putative CheW interface [polypeptide binding]; other site
320389013263	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
320389013264	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
320389013265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389013266	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489
320389013267	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
320389013268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389013269	active site
320389013270	phosphorylation site [posttranslational modification]
320389013271	intermolecular recognition site; other site
320389013272	dimerization interface [polypeptide binding]; other site
320389013273	chemotaxis regulator CheZ; Provisional; Region: PRK11166
320389013274	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
320389013275	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
320389013276	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
320389013277	dimer interface [polypeptide binding]; other site
320389013278	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
320389013279	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
320389013280	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
320389013281	FHIPEP family; Region: FHIPEP; pfam00771
320389013282	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
320389013283	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
320389013284	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
320389013285	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
320389013286	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
320389013287	DNA binding residues [nucleotide binding]
320389013288	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
320389013289	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
320389013290	homotetramer interface [polypeptide binding]; other site
320389013291	ligand binding site [chemical binding]; other site
320389013292	catalytic site [active]
320389013293	NAD binding site [chemical binding]; other site
320389013294	Predicted membrane protein [Function unknown]; Region: COG1950
320389013295	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
320389013296	FAD binding site [chemical binding]; other site
320389013297	amidase; Provisional; Region: PRK07869
320389013298	Amidase; Region: Amidase; cl11426
320389013299	Dienelactone hydrolase family; Region: DLH; pfam01738
320389013300	Transposase; Region: HTH_Tnp_1; pfam01527
320389013301	HTH-like domain; Region: HTH_21; pfam13276
320389013302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389013303	Integrase core domain; Region: rve; pfam00665
320389013304	Integrase core domain; Region: rve_3; pfam13683
320389013305	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
320389013306	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
320389013307	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
320389013308	Clp amino terminal domain; Region: Clp_N; pfam02861
320389013309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389013310	Walker A motif; other site
320389013311	ATP binding site [chemical binding]; other site
320389013312	Walker B motif; other site
320389013313	arginine finger; other site
320389013314	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389013315	Walker A motif; other site
320389013316	ATP binding site [chemical binding]; other site
320389013317	Walker B motif; other site
320389013318	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
320389013319	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
320389013320	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
320389013321	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
320389013322	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
320389013323	ligand binding site [chemical binding]; other site
320389013324	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
320389013325	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
320389013326	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
320389013327	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
320389013328	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
320389013329	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
320389013330	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
320389013331	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
320389013332	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
320389013333	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
320389013334	putative active site [active]
320389013335	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
320389013336	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
320389013337	Walker A/P-loop; other site
320389013338	ATP binding site [chemical binding]; other site
320389013339	Q-loop/lid; other site
320389013340	ABC transporter signature motif; other site
320389013341	Walker B; other site
320389013342	D-loop; other site
320389013343	H-loop/switch region; other site
320389013344	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
320389013345	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
320389013346	HlyD family secretion protein; Region: HlyD_3; pfam13437
320389013347	Peptidase family M1; Region: Peptidase_M1; pfam01433
320389013348	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
320389013349	Zn binding site [ion binding]; other site
320389013350	Water Stress and Hypersensitive response; Region: WHy; smart00769
320389013351	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
320389013352	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
320389013353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389013354	S-adenosylmethionine binding site [chemical binding]; other site
320389013355	Methyltransferase domain; Region: Methyltransf_32; pfam13679
320389013356	Methyltransferase domain; Region: Methyltransf_31; pfam13847
320389013357	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
320389013358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389013359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389013360	D-galactonate transporter; Region: 2A0114; TIGR00893
320389013361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389013362	putative substrate translocation pore; other site
320389013363	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
320389013364	putative FMN binding site [chemical binding]; other site
320389013365	putative chaperone; Provisional; Region: PRK11678
320389013366	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
320389013367	nucleotide binding site [chemical binding]; other site
320389013368	putative NEF/HSP70 interaction site [polypeptide binding]; other site
320389013369	SBD interface [polypeptide binding]; other site
320389013370	Transposase domain (DUF772); Region: DUF772; pfam05598
320389013371	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389013372	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389013373	Predicted methyltransferases [General function prediction only]; Region: COG0313
320389013374	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
320389013375	putative SAM binding site [chemical binding]; other site
320389013376	putative homodimer interface [polypeptide binding]; other site
320389013377	hypothetical protein; Provisional; Region: PRK14673
320389013378	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
320389013379	dimer interface [polypeptide binding]; other site
320389013380	active site
320389013381	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
320389013382	BON domain; Region: BON; pfam04972
320389013383	BON domain; Region: BON; pfam04972
320389013384	Cytochrome c; Region: Cytochrom_C; cl11414
320389013385	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
320389013386	HTH-like domain; Region: HTH_21; pfam13276
320389013387	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389013388	Integrase core domain; Region: rve; pfam00665
320389013389	Integrase core domain; Region: rve_3; pfam13683
320389013390	Transposase; Region: HTH_Tnp_1; pfam01527
320389013391	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
320389013392	DNA-binding site [nucleotide binding]; DNA binding site
320389013393	RNA-binding motif; other site
320389013394	Transposase domain (DUF772); Region: DUF772; pfam05598
320389013395	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389013396	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389013397	lipoyl synthase; Provisional; Region: PRK05481
320389013398	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
320389013399	FeS/SAM binding site; other site
320389013400	lipoate-protein ligase B; Provisional; Region: PRK14343
320389013401	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
320389013402	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
320389013403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389013404	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
320389013405	dimerization interface [polypeptide binding]; other site
320389013406	substrate binding pocket [chemical binding]; other site
320389013407	hypothetical protein; Provisional; Region: PRK02047
320389013408	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
320389013409	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
320389013410	homodimer interface [polypeptide binding]; other site
320389013411	substrate-cofactor binding pocket; other site
320389013412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
320389013413	catalytic residue [active]
320389013414	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
320389013415	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
320389013416	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
320389013417	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
320389013418	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
320389013419	dimer interface [polypeptide binding]; other site
320389013420	[2Fe-2S] cluster binding site [ion binding]; other site
320389013421	Protein of unknown function (DUF330); Region: DUF330; pfam03886
320389013422	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
320389013423	mce related protein; Region: MCE; pfam02470
320389013424	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
320389013425	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
320389013426	Walker A/P-loop; other site
320389013427	ATP binding site [chemical binding]; other site
320389013428	Q-loop/lid; other site
320389013429	ABC transporter signature motif; other site
320389013430	Walker B; other site
320389013431	D-loop; other site
320389013432	H-loop/switch region; other site
320389013433	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
320389013434	Permease; Region: Permease; pfam02405
320389013435	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
320389013436	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
320389013437	active site
320389013438	metal binding site [ion binding]; metal-binding site
320389013439	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
320389013440	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
320389013441	Sel1-like repeats; Region: SEL1; smart00671
320389013442	Sel1-like repeats; Region: SEL1; smart00671
320389013443	biotin--protein ligase; Provisional; Region: PRK06955
320389013444	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
320389013445	pantothenate kinase; Reviewed; Region: PRK13328
320389013446	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
320389013447	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
320389013448	active site
320389013449	HIGH motif; other site
320389013450	nucleotide binding site [chemical binding]; other site
320389013451	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
320389013452	dinuclear metal binding motif [ion binding]; other site
320389013453	enoyl-CoA hydratase; Provisional; Region: PRK07657
320389013454	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
320389013455	substrate binding site [chemical binding]; other site
320389013456	oxyanion hole (OAH) forming residues; other site
320389013457	trimer interface [polypeptide binding]; other site
320389013458	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
320389013459	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
320389013460	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
320389013461	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389013462	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389013463	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389013464	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
320389013465	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
320389013466	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
320389013467	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
320389013468	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
320389013469	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
320389013470	substrate binding pocket [chemical binding]; other site
320389013471	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
320389013472	B12 binding site [chemical binding]; other site
320389013473	cobalt ligand [ion binding]; other site
320389013474	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
320389013475	Transposase domain (DUF772); Region: DUF772; pfam05598
320389013476	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389013477	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389013478	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389013479	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389013480	trimer interface [polypeptide binding]; other site
320389013481	eyelet of channel; other site
320389013482	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
320389013483	diiron binding motif [ion binding]; other site
320389013484	cell division protein MraZ; Reviewed; Region: PRK00326
320389013485	MraZ protein; Region: MraZ; pfam02381
320389013486	MraZ protein; Region: MraZ; pfam02381
320389013487	MraW methylase family; Region: Methyltransf_5; cl17771
320389013488	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
320389013489	Cell division protein FtsL; Region: FtsL; pfam04999
320389013490	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
320389013491	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
320389013492	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
320389013493	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
320389013494	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
320389013495	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
320389013496	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
320389013497	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
320389013498	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
320389013499	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
320389013500	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
320389013501	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
320389013502	Mg++ binding site [ion binding]; other site
320389013503	putative catalytic motif [active]
320389013504	putative substrate binding site [chemical binding]; other site
320389013505	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
320389013506	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
320389013507	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
320389013508	cell division protein FtsW; Region: ftsW; TIGR02614
320389013509	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
320389013510	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
320389013511	active site
320389013512	homodimer interface [polypeptide binding]; other site
320389013513	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
320389013514	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
320389013515	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
320389013516	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
320389013517	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
320389013518	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
320389013519	ATP-grasp domain; Region: ATP-grasp_4; cl17255
320389013520	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
320389013521	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
320389013522	Cell division protein FtsQ; Region: FtsQ; pfam03799
320389013523	cell division protein FtsA; Region: ftsA; TIGR01174
320389013524	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
320389013525	nucleotide binding site [chemical binding]; other site
320389013526	Cell division protein FtsA; Region: FtsA; pfam14450
320389013527	cell division protein FtsZ; Validated; Region: PRK09330
320389013528	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
320389013529	nucleotide binding site [chemical binding]; other site
320389013530	SulA interaction site; other site
320389013531	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
320389013532	catalytic triad [active]
320389013533	dimer interface [polypeptide binding]; other site
320389013534	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
320389013535	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
320389013536	Protein of unknown function (DUF721); Region: DUF721; pfam05258
320389013537	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
320389013538	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
320389013539	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
320389013540	SEC-C motif; Region: SEC-C; pfam02810
320389013541	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
320389013542	heterotetramer interface [polypeptide binding]; other site
320389013543	active site pocket [active]
320389013544	cleavage site
320389013545	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
320389013546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389013547	Walker A motif; other site
320389013548	ATP binding site [chemical binding]; other site
320389013549	Walker B motif; other site
320389013550	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
320389013551	active site
320389013552	8-oxo-dGMP binding site [chemical binding]; other site
320389013553	nudix motif; other site
320389013554	metal binding site [ion binding]; metal-binding site
320389013555	Domain of unknown function (DUF329); Region: DUF329; pfam03884
320389013556	hypothetical protein; Provisional; Region: PRK05287
320389013557	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
320389013558	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
320389013559	CoA-binding site [chemical binding]; other site
320389013560	ATP-binding [chemical binding]; other site
320389013561	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
320389013562	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
320389013563	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
320389013564	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
320389013565	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389013566	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
320389013567	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
320389013568	Walker A motif; other site
320389013569	ATP binding site [chemical binding]; other site
320389013570	Walker B motif; other site
320389013571	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
320389013572	Domain of unknown function DUF21; Region: DUF21; pfam01595
320389013573	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
320389013574	Transporter associated domain; Region: CorC_HlyC; smart01091
320389013575	Transposase; Region: HTH_Tnp_1; pfam01527
320389013576	HTH-like domain; Region: HTH_21; pfam13276
320389013577	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389013578	Integrase core domain; Region: rve; pfam00665
320389013579	Integrase core domain; Region: rve_3; pfam13683
320389013580	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
320389013581	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
320389013582	substrate binding pocket [chemical binding]; other site
320389013583	chain length determination region; other site
320389013584	substrate-Mg2+ binding site; other site
320389013585	catalytic residues [active]
320389013586	aspartate-rich region 1; other site
320389013587	active site lid residues [active]
320389013588	aspartate-rich region 2; other site
320389013589	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
320389013590	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
320389013591	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
320389013592	GTPase CgtA; Reviewed; Region: obgE; PRK12298
320389013593	GTP1/OBG; Region: GTP1_OBG; pfam01018
320389013594	Obg GTPase; Region: Obg; cd01898
320389013595	G1 box; other site
320389013596	GTP/Mg2+ binding site [chemical binding]; other site
320389013597	Switch I region; other site
320389013598	G2 box; other site
320389013599	G3 box; other site
320389013600	Switch II region; other site
320389013601	G4 box; other site
320389013602	G5 box; other site
320389013603	gamma-glutamyl kinase; Provisional; Region: PRK05429
320389013604	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
320389013605	nucleotide binding site [chemical binding]; other site
320389013606	homotetrameric interface [polypeptide binding]; other site
320389013607	putative phosphate binding site [ion binding]; other site
320389013608	putative allosteric binding site; other site
320389013609	PUA domain; Region: PUA; pfam01472
320389013610	Transposase domain (DUF772); Region: DUF772; pfam05598
320389013611	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389013612	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389013613	CNP1-like family; Region: CNP1; pfam08750
320389013614	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
320389013615	putative active site [active]
320389013616	Ap4A binding site [chemical binding]; other site
320389013617	nudix motif; other site
320389013618	putative metal binding site [ion binding]; other site
320389013619	prolyl-tRNA synthetase; Provisional; Region: PRK09194
320389013620	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
320389013621	dimer interface [polypeptide binding]; other site
320389013622	motif 1; other site
320389013623	active site
320389013624	motif 2; other site
320389013625	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
320389013626	putative deacylase active site [active]
320389013627	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
320389013628	active site
320389013629	motif 3; other site
320389013630	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
320389013631	anticodon binding site; other site
320389013632	MarC family integral membrane protein; Region: MarC; cl00919
320389013633	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389013634	active site
320389013635	signal recognition particle protein; Provisional; Region: PRK10867
320389013636	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
320389013637	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
320389013638	P loop; other site
320389013639	GTP binding site [chemical binding]; other site
320389013640	Signal peptide binding domain; Region: SRP_SPB; pfam02978
320389013641	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
320389013642	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
320389013643	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
320389013644	amidase catalytic site [active]
320389013645	Zn binding residues [ion binding]; other site
320389013646	substrate binding site [chemical binding]; other site
320389013647	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
320389013648	ATP cone domain; Region: ATP-cone; pfam03477
320389013649	Class I ribonucleotide reductase; Region: RNR_I; cd01679
320389013650	active site
320389013651	dimer interface [polypeptide binding]; other site
320389013652	catalytic residues [active]
320389013653	effector binding site; other site
320389013654	R2 peptide binding site; other site
320389013655	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
320389013656	dimer interface [polypeptide binding]; other site
320389013657	putative radical transfer pathway; other site
320389013658	diiron center [ion binding]; other site
320389013659	tyrosyl radical; other site
320389013660	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
320389013661	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
320389013662	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
320389013663	substrate binding site [chemical binding]; other site
320389013664	ATP binding site [chemical binding]; other site
320389013665	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
320389013666	dimer interface [polypeptide binding]; other site
320389013667	catalytic triad [active]
320389013668	peroxidatic and resolving cysteines [active]
320389013669	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
320389013670	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
320389013671	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
320389013672	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
320389013673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389013674	S-adenosylmethionine binding site [chemical binding]; other site
320389013675	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
320389013676	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
320389013677	ATP-grasp domain; Region: ATP-grasp_4; cl17255
320389013678	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
320389013679	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
320389013680	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
320389013681	carboxyltransferase (CT) interaction site; other site
320389013682	biotinylation site [posttranslational modification]; other site
320389013683	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
320389013684	Dehydroquinase class II; Region: DHquinase_II; pfam01220
320389013685	active site
320389013686	trimer interface [polypeptide binding]; other site
320389013687	dimer interface [polypeptide binding]; other site
320389013688	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
320389013689	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389013690	catalytic residues [active]
320389013691	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
320389013692	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
320389013693	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
320389013694	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
320389013695	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
320389013696	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
320389013697	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
320389013698	RNB domain; Region: RNB; pfam00773
320389013699	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
320389013700	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
320389013701	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
320389013702	shikimate binding site; other site
320389013703	NAD(P) binding site [chemical binding]; other site
320389013704	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
320389013705	Transglycosylase; Region: Transgly; cl17702
320389013706	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
320389013707	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
320389013708	Transcriptional regulator [Transcription]; Region: IclR; COG1414
320389013709	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
320389013710	Bacterial transcriptional regulator; Region: IclR; pfam01614
320389013711	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
320389013712	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
320389013713	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
320389013714	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
320389013715	active site
320389013716	intersubunit interface [polypeptide binding]; other site
320389013717	catalytic residue [active]
320389013718	short chain dehydrogenase; Provisional; Region: PRK07063
320389013719	classical (c) SDRs; Region: SDR_c; cd05233
320389013720	NAD(P) binding site [chemical binding]; other site
320389013721	active site
320389013722	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
320389013723	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
320389013724	ligand binding site [chemical binding]; other site
320389013725	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
320389013726	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
320389013727	Walker A/P-loop; other site
320389013728	ATP binding site [chemical binding]; other site
320389013729	Q-loop/lid; other site
320389013730	ABC transporter signature motif; other site
320389013731	Walker B; other site
320389013732	D-loop; other site
320389013733	H-loop/switch region; other site
320389013734	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
320389013735	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
320389013736	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
320389013737	TM-ABC transporter signature motif; other site
320389013738	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
320389013739	classical (c) SDRs; Region: SDR_c; cd05233
320389013740	NAD(P) binding site [chemical binding]; other site
320389013741	active site
320389013742	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
320389013743	active site
320389013744	catalytic residues [active]
320389013745	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
320389013746	active site
320389013747	dimer interface [polypeptide binding]; other site
320389013748	Competence-damaged protein; Region: CinA; pfam02464
320389013749	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
320389013750	tetramer interfaces [polypeptide binding]; other site
320389013751	binuclear metal-binding site [ion binding]; other site
320389013752	thiamine monophosphate kinase; Provisional; Region: PRK05731
320389013753	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
320389013754	ATP binding site [chemical binding]; other site
320389013755	dimerization interface [polypeptide binding]; other site
320389013756	malic enzyme; Reviewed; Region: PRK12862
320389013757	Malic enzyme, N-terminal domain; Region: malic; pfam00390
320389013758	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
320389013759	putative NAD(P) binding site [chemical binding]; other site
320389013760	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
320389013761	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
320389013762	active site
320389013763	barstar interaction site; other site
320389013764	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
320389013765	putative RNAase interaction site [polypeptide binding]; other site
320389013766	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
320389013767	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
320389013768	putative dimer interface [polypeptide binding]; other site
320389013769	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
320389013770	spermidine synthase; Provisional; Region: PRK00811
320389013771	Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421
320389013772	transketolase; Reviewed; Region: PRK12753
320389013773	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
320389013774	TPP-binding site [chemical binding]; other site
320389013775	dimer interface [polypeptide binding]; other site
320389013776	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
320389013777	PYR/PP interface [polypeptide binding]; other site
320389013778	dimer interface [polypeptide binding]; other site
320389013779	TPP binding site [chemical binding]; other site
320389013780	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
320389013781	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
320389013782	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
320389013783	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
320389013784	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
320389013785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389013786	cyanate hydratase; Validated; Region: PRK02866
320389013787	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
320389013788	oligomer interface [polypeptide binding]; other site
320389013789	active site
320389013790	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
320389013791	active site clefts [active]
320389013792	zinc binding site [ion binding]; other site
320389013793	dimer interface [polypeptide binding]; other site
320389013794	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
320389013795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
320389013796	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
320389013797	dimerization interface [polypeptide binding]; other site
320389013798	Transcriptional regulators [Transcription]; Region: FadR; COG2186
320389013799	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
320389013800	DNA-binding site [nucleotide binding]; DNA binding site
320389013801	FCD domain; Region: FCD; pfam07729
320389013802	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
320389013803	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
320389013804	Transposase; Region: HTH_Tnp_1; pfam01527
320389013805	HTH-like domain; Region: HTH_21; pfam13276
320389013806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389013807	Integrase core domain; Region: rve; pfam00665
320389013808	Integrase core domain; Region: rve_3; pfam13683
320389013809	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
320389013810	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
320389013811	ligand binding site; other site
320389013812	putative membrane protein; Region: HpnL; TIGR03476
320389013813	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
320389013814	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
320389013815	trimer interface [polypeptide binding]; other site
320389013816	eyelet of channel; other site
320389013817	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
320389013818	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
320389013819	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
320389013820	PhnA protein; Region: PhnA; pfam03831
320389013821	Chromate transporter; Region: Chromate_transp; pfam02417
320389013822	Chromate transporter; Region: Chromate_transp; pfam02417
320389013823	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
320389013824	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
320389013825	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
320389013826	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
320389013827	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
320389013828	Flagellar regulator YcgR; Region: YcgR; pfam07317
320389013829	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
320389013830	PilZ domain; Region: PilZ; pfam07238
320389013831	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709
320389013832	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
320389013833	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
320389013834	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
320389013835	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
320389013836	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697
320389013837	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
320389013838	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
320389013839	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
320389013840	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
320389013841	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
320389013842	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
320389013843	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
320389013844	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
320389013845	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
320389013846	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
320389013847	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
320389013848	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
320389013849	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
320389013850	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
320389013851	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
320389013852	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
320389013853	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
320389013854	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626
320389013855	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
320389013856	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
320389013857	FlgN protein; Region: FlgN; pfam05130
320389013858	Killing trait; Region: RebB; pfam11747
320389013859	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
320389013860	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
320389013861	active site
320389013862	NTP binding site [chemical binding]; other site
320389013863	metal binding triad [ion binding]; metal-binding site
320389013864	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
320389013865	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
320389013866	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
320389013867	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
320389013868	putative C-terminal domain interface [polypeptide binding]; other site
320389013869	putative GSH binding site (G-site) [chemical binding]; other site
320389013870	putative dimer interface [polypeptide binding]; other site
320389013871	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
320389013872	putative N-terminal domain interface [polypeptide binding]; other site
320389013873	putative dimer interface [polypeptide binding]; other site
320389013874	putative substrate binding pocket (H-site) [chemical binding]; other site
320389013875	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
320389013876	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
320389013877	putative NAD(P) binding site [chemical binding]; other site
320389013878	active site
320389013879	lytic murein transglycosylase; Provisional; Region: PRK11619
320389013880	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
320389013881	N-acetyl-D-glucosamine binding site [chemical binding]; other site
320389013882	catalytic residue [active]
320389013883	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
320389013884	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
320389013885	MarR family; Region: MarR_2; cl17246
320389013886	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
320389013887	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
320389013888	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
320389013889	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
320389013890	putative active site [active]
320389013891	Protein of unknown function (DUF969); Region: DUF969; pfam06149
320389013892	Predicted membrane protein [Function unknown]; Region: COG3817
320389013893	Protein of unknown function (DUF979); Region: DUF979; pfam06166
320389013894	TraB family; Region: TraB; pfam01963
320389013895	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
320389013896	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389013897	Walker A/P-loop; other site
320389013898	ATP binding site [chemical binding]; other site
320389013899	Q-loop/lid; other site
320389013900	ABC transporter signature motif; other site
320389013901	Walker B; other site
320389013902	D-loop; other site
320389013903	H-loop/switch region; other site
320389013904	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
320389013905	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
320389013906	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
320389013907	Walker A/P-loop; other site
320389013908	ATP binding site [chemical binding]; other site
320389013909	Q-loop/lid; other site
320389013910	ABC transporter signature motif; other site
320389013911	Walker B; other site
320389013912	D-loop; other site
320389013913	H-loop/switch region; other site
320389013914	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
320389013915	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
320389013916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
320389013917	dimer interface [polypeptide binding]; other site
320389013918	conserved gate region; other site
320389013919	putative PBP binding loops; other site
320389013920	ABC-ATPase subunit interface; other site
320389013921	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
320389013922	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
320389013923	peptide binding site [polypeptide binding]; other site
320389013924	citrate-proton symporter; Provisional; Region: PRK15075
320389013925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389013926	putative substrate translocation pore; other site
320389013927	High potential iron-sulfur protein; Region: HIPIP; pfam01355
320389013928	Predicted dehydrogenase [General function prediction only]; Region: COG0579
320389013929	hydroxyglutarate oxidase; Provisional; Region: PRK11728
320389013930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389013931	Walker A motif; other site
320389013932	ATP binding site [chemical binding]; other site
320389013933	Walker B motif; other site
320389013934	arginine finger; other site
320389013935	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
320389013936	putative catalytic site [active]
320389013937	putative phosphate binding site [ion binding]; other site
320389013938	putative metal binding site [ion binding]; other site
320389013939	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
320389013940	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
320389013941	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
320389013942	FAD binding pocket [chemical binding]; other site
320389013943	FAD binding motif [chemical binding]; other site
320389013944	phosphate binding motif [ion binding]; other site
320389013945	beta-alpha-beta structure motif; other site
320389013946	NAD binding pocket [chemical binding]; other site
320389013947	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
320389013948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389013949	active site
320389013950	phosphorylation site [posttranslational modification]
320389013951	intermolecular recognition site; other site
320389013952	dimerization interface [polypeptide binding]; other site
320389013953	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
320389013954	DNA binding residues [nucleotide binding]
320389013955	dimerization interface [polypeptide binding]; other site
320389013956	amino acid transporter; Region: 2A0306; TIGR00909
320389013957	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
320389013958	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
320389013959	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
320389013960	XdhC Rossmann domain; Region: XdhC_C; pfam13478
320389013961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
320389013962	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
320389013963	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
320389013964	Flagellar protein FliT; Region: FliT; cl05125
320389013965	flagellar protein FliS; Validated; Region: fliS; PRK05685
320389013966	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
320389013967	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
320389013968	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
320389013969	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
320389013970	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
320389013971	FliG C-terminal domain; Region: FliG_C; pfam01706
320389013972	flagellar assembly protein H; Validated; Region: fliH; PRK05687
320389013973	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
320389013974	Flagellar assembly protein FliH; Region: FliH; pfam02108
320389013975	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
320389013976	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
320389013977	Walker A motif/ATP binding site; other site
320389013978	Walker B motif; other site
320389013979	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
320389013980	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
320389013981	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
320389013982	choline dehydrogenase; Validated; Region: PRK02106
320389013983	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
320389013984	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
320389013985	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
320389013986	NAD(P) binding site [chemical binding]; other site
320389013987	catalytic residues [active]
320389013988	serine/threonine protein kinase; Provisional; Region: PRK11768
320389013989	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
320389013990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389013991	putative substrate translocation pore; other site
320389013992	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
320389013993	EamA-like transporter family; Region: EamA; pfam00892
320389013994	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
320389013995	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
320389013996	active site
320389013997	catalytic tetrad [active]
320389013998	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
320389013999	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
320389014000	S-adenosylmethionine synthetase; Validated; Region: PRK05250
320389014001	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
320389014002	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
320389014003	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
320389014004	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
320389014005	putative acyl-acceptor binding pocket; other site
320389014006	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
320389014007	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
320389014008	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
320389014009	Protein of unknown function, DUF484; Region: DUF484; cl17449
320389014010	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
320389014011	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
320389014012	active site
320389014013	DNA binding site [nucleotide binding]
320389014014	Int/Topo IB signature motif; other site
320389014015	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
320389014016	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
320389014017	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
320389014018	putative RNA binding site [nucleotide binding]; other site
320389014019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
320389014020	S-adenosylmethionine binding site [chemical binding]; other site
320389014021	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
320389014022	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
320389014023	P-loop, Walker A motif; other site
320389014024	Base recognition motif; other site
320389014025	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
320389014026	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
320389014027	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
320389014028	active site
320389014029	HslU subunit interaction site [polypeptide binding]; other site
320389014030	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
320389014031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
320389014032	Walker A motif; other site
320389014033	ATP binding site [chemical binding]; other site
320389014034	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
320389014035	Walker B motif; other site
320389014036	arginine finger; other site
320389014037	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
320389014038	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
320389014039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
320389014040	active site
320389014041	phosphorylation site [posttranslational modification]
320389014042	intermolecular recognition site; other site
320389014043	dimerization interface [polypeptide binding]; other site
320389014044	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
320389014045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
320389014046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
320389014047	dimer interface [polypeptide binding]; other site
320389014048	phosphorylation site [posttranslational modification]
320389014049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
320389014050	ATP binding site [chemical binding]; other site
320389014051	Mg2+ binding site [ion binding]; other site
320389014052	G-X-G motif; other site
320389014053	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
320389014054	feedback inhibition sensing region; other site
320389014055	homohexameric interface [polypeptide binding]; other site
320389014056	nucleotide binding site [chemical binding]; other site
320389014057	N-acetyl-L-glutamate binding site [chemical binding]; other site
320389014058	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
320389014059	division inhibitor protein; Provisional; Region: slmA; PRK09480
320389014060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389014061	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
320389014062	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
320389014063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
320389014064	muropeptide transporter; Reviewed; Region: ampG; PRK11902
320389014065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
320389014066	putative substrate translocation pore; other site
320389014067	Peptidase family M48; Region: Peptidase_M48; cl12018
320389014068	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
320389014069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
320389014070	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
320389014071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389014072	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389014073	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
320389014074	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
320389014075	putative NAD(P) binding site [chemical binding]; other site
320389014076	putative substrate binding site [chemical binding]; other site
320389014077	catalytic Zn binding site [ion binding]; other site
320389014078	structural Zn binding site [ion binding]; other site
320389014079	dimer interface [polypeptide binding]; other site
320389014080	Transposase domain (DUF772); Region: DUF772; pfam05598
320389014081	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389014082	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389014083	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
320389014084	putative iron binding site [ion binding]; other site
320389014085	diaminopimelate decarboxylase; Region: lysA; TIGR01048
320389014086	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
320389014087	active site
320389014088	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
320389014089	substrate binding site [chemical binding]; other site
320389014090	catalytic residues [active]
320389014091	dimer interface [polypeptide binding]; other site
320389014092	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
320389014093	TMAO/DMSO reductase; Reviewed; Region: PRK05363
320389014094	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
320389014095	Moco binding site; other site
320389014096	metal coordination site [ion binding]; other site
320389014097	HTH-like domain; Region: HTH_21; pfam13276
320389014098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389014099	Integrase core domain; Region: rve; pfam00665
320389014100	Integrase core domain; Region: rve_3; pfam13683
320389014101	Transposase; Region: HTH_Tnp_1; pfam01527
320389014102	elongation factor Tu; Reviewed; Region: PRK00049
320389014103	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
320389014104	G1 box; other site
320389014105	GEF interaction site [polypeptide binding]; other site
320389014106	GTP/Mg2+ binding site [chemical binding]; other site
320389014107	Switch I region; other site
320389014108	G2 box; other site
320389014109	G3 box; other site
320389014110	Switch II region; other site
320389014111	G4 box; other site
320389014112	G5 box; other site
320389014113	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
320389014114	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
320389014115	Antibiotic Binding Site [chemical binding]; other site
320389014116	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
320389014117	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
320389014118	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
320389014119	putative homodimer interface [polypeptide binding]; other site
320389014120	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
320389014121	heterodimer interface [polypeptide binding]; other site
320389014122	homodimer interface [polypeptide binding]; other site
320389014123	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
320389014124	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
320389014125	23S rRNA interface [nucleotide binding]; other site
320389014126	L7/L12 interface [polypeptide binding]; other site
320389014127	putative thiostrepton binding site; other site
320389014128	L25 interface [polypeptide binding]; other site
320389014129	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
320389014130	mRNA/rRNA interface [nucleotide binding]; other site
320389014131	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
320389014132	23S rRNA interface [nucleotide binding]; other site
320389014133	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
320389014134	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
320389014135	peripheral dimer interface [polypeptide binding]; other site
320389014136	core dimer interface [polypeptide binding]; other site
320389014137	L10 interface [polypeptide binding]; other site
320389014138	L11 interface [polypeptide binding]; other site
320389014139	putative EF-Tu interaction site [polypeptide binding]; other site
320389014140	putative EF-G interaction site [polypeptide binding]; other site
320389014141	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
320389014142	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
320389014143	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
320389014144	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
320389014145	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
320389014146	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
320389014147	RPB3 interaction site [polypeptide binding]; other site
320389014148	RPB1 interaction site [polypeptide binding]; other site
320389014149	RPB11 interaction site [polypeptide binding]; other site
320389014150	RPB10 interaction site [polypeptide binding]; other site
320389014151	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
320389014152	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
320389014153	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
320389014154	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
320389014155	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
320389014156	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
320389014157	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
320389014158	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
320389014159	DNA binding site [nucleotide binding]
320389014160	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
320389014161	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
320389014162	Transposase; Region: DDE_Tnp_ISL3; pfam01610
320389014163	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
320389014164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
320389014165	ATP binding site [chemical binding]; other site
320389014166	putative Mg++ binding site [ion binding]; other site
320389014167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
320389014168	nucleotide binding region [chemical binding]; other site
320389014169	ATP-binding site [chemical binding]; other site
320389014170	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
320389014171	HRDC domain; Region: HRDC; pfam00570
320389014172	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
320389014173	S17 interaction site [polypeptide binding]; other site
320389014174	S8 interaction site; other site
320389014175	16S rRNA interaction site [nucleotide binding]; other site
320389014176	streptomycin interaction site [chemical binding]; other site
320389014177	23S rRNA interaction site [nucleotide binding]; other site
320389014178	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
320389014179	30S ribosomal protein S7; Validated; Region: PRK05302
320389014180	elongation factor G; Reviewed; Region: PRK00007
320389014181	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
320389014182	G1 box; other site
320389014183	putative GEF interaction site [polypeptide binding]; other site
320389014184	GTP/Mg2+ binding site [chemical binding]; other site
320389014185	Switch I region; other site
320389014186	G2 box; other site
320389014187	G3 box; other site
320389014188	Switch II region; other site
320389014189	G4 box; other site
320389014190	G5 box; other site
320389014191	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
320389014192	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
320389014193	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
320389014194	elongation factor Tu; Reviewed; Region: PRK00049
320389014195	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
320389014196	G1 box; other site
320389014197	GEF interaction site [polypeptide binding]; other site
320389014198	GTP/Mg2+ binding site [chemical binding]; other site
320389014199	Switch I region; other site
320389014200	G2 box; other site
320389014201	G3 box; other site
320389014202	Switch II region; other site
320389014203	G4 box; other site
320389014204	G5 box; other site
320389014205	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
320389014206	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
320389014207	Antibiotic Binding Site [chemical binding]; other site
320389014208	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
320389014209	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
320389014210	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
320389014211	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
320389014212	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
320389014213	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
320389014214	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
320389014215	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
320389014216	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
320389014217	putative translocon binding site; other site
320389014218	protein-rRNA interface [nucleotide binding]; other site
320389014219	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
320389014220	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
320389014221	G-X-X-G motif; other site
320389014222	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
320389014223	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
320389014224	23S rRNA interface [nucleotide binding]; other site
320389014225	5S rRNA interface [nucleotide binding]; other site
320389014226	putative antibiotic binding site [chemical binding]; other site
320389014227	L25 interface [polypeptide binding]; other site
320389014228	L27 interface [polypeptide binding]; other site
320389014229	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
320389014230	23S rRNA interface [nucleotide binding]; other site
320389014231	putative translocon interaction site; other site
320389014232	signal recognition particle (SRP54) interaction site; other site
320389014233	L23 interface [polypeptide binding]; other site
320389014234	trigger factor interaction site; other site
320389014235	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
320389014236	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
320389014237	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
320389014238	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
320389014239	RNA binding site [nucleotide binding]; other site
320389014240	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
320389014241	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
320389014242	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
320389014243	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
320389014244	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
320389014245	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
320389014246	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
320389014247	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
320389014248	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
320389014249	5S rRNA interface [nucleotide binding]; other site
320389014250	L27 interface [polypeptide binding]; other site
320389014251	23S rRNA interface [nucleotide binding]; other site
320389014252	L5 interface [polypeptide binding]; other site
320389014253	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
320389014254	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
320389014255	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
320389014256	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
320389014257	23S rRNA binding site [nucleotide binding]; other site
320389014258	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
320389014259	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
320389014260	SecY translocase; Region: SecY; pfam00344
320389014261	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
320389014262	rRNA binding site [nucleotide binding]; other site
320389014263	predicted 30S ribosome binding site; other site
320389014264	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
320389014265	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
320389014266	30S ribosomal protein S13; Region: bact_S13; TIGR03631
320389014267	30S ribosomal protein S11; Validated; Region: PRK05309
320389014268	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
320389014269	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
320389014270	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
320389014271	RNA binding surface [nucleotide binding]; other site
320389014272	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
320389014273	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
320389014274	alphaNTD homodimer interface [polypeptide binding]; other site
320389014275	alphaNTD - beta interaction site [polypeptide binding]; other site
320389014276	alphaNTD - beta' interaction site [polypeptide binding]; other site
320389014277	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
320389014278	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
320389014279	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
320389014280	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
320389014281	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
320389014282	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
320389014283	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
320389014284	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
320389014285	DsbD alpha interface [polypeptide binding]; other site
320389014286	catalytic residues [active]
320389014287	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
320389014288	dimer interface [polypeptide binding]; other site
320389014289	active site
320389014290	aspartate-rich active site metal binding site; other site
320389014291	allosteric magnesium binding site [ion binding]; other site
320389014292	Schiff base residues; other site
320389014293	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
320389014294	G1 box; other site
320389014295	GTP/Mg2+ binding site [chemical binding]; other site
320389014296	Switch I region; other site
320389014297	G2 box; other site
320389014298	G3 box; other site
320389014299	Switch II region; other site
320389014300	G4 box; other site
320389014301	G5 box; other site
320389014302	Cytochrome c553 [Energy production and conversion]; Region: COG2863
320389014303	Cytochrome c; Region: Cytochrom_C; cl11414
320389014304	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
320389014305	ResB-like family; Region: ResB; pfam05140
320389014306	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
320389014307	ResB-like family; Region: ResB; pfam05140
320389014308	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
320389014309	Transposase; Region: HTH_Tnp_1; pfam01527
320389014310	HTH-like domain; Region: HTH_21; pfam13276
320389014311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389014312	Integrase core domain; Region: rve; pfam00665
320389014313	Integrase core domain; Region: rve_3; pfam13683
320389014314	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
320389014315	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
320389014316	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
320389014317	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
320389014318	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
320389014319	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
320389014320	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
320389014321	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
320389014322	substrate binding site [chemical binding]; other site
320389014323	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
320389014324	active site
320389014325	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
320389014326	Malic enzyme, N-terminal domain; Region: malic; pfam00390
320389014327	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
320389014328	putative NAD(P) binding site [chemical binding]; other site
320389014329	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
320389014330	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
320389014331	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
320389014332	dimer interface [polypeptide binding]; other site
320389014333	PYR/PP interface [polypeptide binding]; other site
320389014334	TPP binding site [chemical binding]; other site
320389014335	substrate binding site [chemical binding]; other site
320389014336	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
320389014337	TPP-binding site; other site
320389014338	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
320389014339	Transposase domain (DUF772); Region: DUF772; pfam05598
320389014340	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
320389014341	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
320389014342	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
320389014343	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
320389014344	dimer interface [polypeptide binding]; other site
320389014345	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
320389014346	active site
320389014347	Fe binding site [ion binding]; other site
320389014348	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
320389014349	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
320389014350	putative DNA binding site [nucleotide binding]; other site
320389014351	putative Zn2+ binding site [ion binding]; other site
320389014352	AsnC family; Region: AsnC_trans_reg; pfam01037
320389014353	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
320389014354	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
320389014355	Coenzyme A binding pocket [chemical binding]; other site
320389014356	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
320389014357	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
320389014358	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
320389014359	Protein of unknown function; Region: DUF3658; pfam12395
320389014360	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
320389014361	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
320389014362	FAD binding pocket [chemical binding]; other site
320389014363	FAD binding motif [chemical binding]; other site
320389014364	phosphate binding motif [ion binding]; other site
320389014365	beta-alpha-beta structure motif; other site
320389014366	NAD(p) ribose binding residues [chemical binding]; other site
320389014367	NAD binding pocket [chemical binding]; other site
320389014368	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
320389014369	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
320389014370	catalytic loop [active]
320389014371	iron binding site [ion binding]; other site
320389014372	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
320389014373	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
320389014374	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
320389014375	active site
320389014376	catalytic triad [active]
320389014377	oxyanion hole [active]
320389014378	Transposase; Region: HTH_Tnp_1; pfam01527
320389014379	HTH-like domain; Region: HTH_21; pfam13276
320389014380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
320389014381	Integrase core domain; Region: rve; pfam00665
320389014382	Integrase core domain; Region: rve_3; pfam13683
320389014383	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
320389014384	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
320389014385	trmE is a tRNA modification GTPase; Region: trmE; cd04164
320389014386	G1 box; other site
320389014387	GTP/Mg2+ binding site [chemical binding]; other site
320389014388	Switch I region; other site
320389014389	G2 box; other site
320389014390	Switch II region; other site
320389014391	G3 box; other site
320389014392	G4 box; other site
320389014393	G5 box; other site
320389014394	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
320389014395	membrane protein insertase; Provisional; Region: PRK01318
320389014396	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
320389014397	hypothetical protein; Validated; Region: PRK00041
320389014398	Ribonuclease P; Region: Ribonuclease_P; cl00457
320389014399	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399