-- dump date 20140619_013737 -- class Genbank::misc_feature -- table misc_feature_note -- id note 412022000001 HTH-like domain; Region: HTH_21; pfam13276 412022000002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000003 Integrase core domain; Region: rve; pfam00665 412022000004 Integrase core domain; Region: rve_3; pfam13683 412022000005 Transposase; Region: HTH_Tnp_1; pfam01527 412022000006 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 412022000007 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 412022000008 4Fe-4S binding domain; Region: Fer4_5; pfam12801 412022000009 Iron permease FTR1 family; Region: FTR1; cl00475 412022000010 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 412022000011 Fe2+ transport protein; Region: Iron_transport; pfam10634 412022000012 excinuclease ABC subunit B; Provisional; Region: PRK05298 412022000013 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 412022000014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022000015 ATP-binding site [chemical binding]; other site 412022000016 ATP binding site [chemical binding]; other site 412022000017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022000018 nucleotide binding region [chemical binding]; other site 412022000019 ATP-binding site [chemical binding]; other site 412022000020 Ultra-violet resistance protein B; Region: UvrB; pfam12344 412022000021 UvrB/uvrC motif; Region: UVR; pfam02151 412022000022 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 412022000023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022000024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022000025 homodimer interface [polypeptide binding]; other site 412022000026 catalytic residue [active] 412022000027 Transposase domain (DUF772); Region: DUF772; pfam05598 412022000028 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022000029 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022000030 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 412022000031 classical (c) SDRs; Region: SDR_c; cd05233 412022000032 NAD(P) binding site [chemical binding]; other site 412022000033 active site 412022000034 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 412022000035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412022000036 active site 412022000037 catalytic tetrad [active] 412022000038 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 412022000039 Transposase; Region: HTH_Tnp_1; pfam01527 412022000040 HTH-like domain; Region: HTH_21; pfam13276 412022000041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000042 Integrase core domain; Region: rve; pfam00665 412022000043 Integrase core domain; Region: rve_3; pfam13683 412022000044 Bacitracin resistance protein BacA; Region: BacA; cl00858 412022000045 HTH-like domain; Region: HTH_21; pfam13276 412022000046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000047 Integrase core domain; Region: rve; pfam00665 412022000048 Integrase core domain; Region: rve_3; pfam13683 412022000049 Transposase; Region: HTH_Tnp_1; pfam01527 412022000050 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 412022000051 glutaminase; Provisional; Region: PRK00971 412022000052 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 412022000053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000054 active site 412022000055 phosphorylation site [posttranslational modification] 412022000056 intermolecular recognition site; other site 412022000057 dimerization interface [polypeptide binding]; other site 412022000058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022000059 DNA binding site [nucleotide binding] 412022000060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022000061 dimer interface [polypeptide binding]; other site 412022000062 phosphorylation site [posttranslational modification] 412022000063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000064 ATP binding site [chemical binding]; other site 412022000065 Mg2+ binding site [ion binding]; other site 412022000066 G-X-G motif; other site 412022000067 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 412022000068 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 412022000069 active site 412022000070 nucleophile elbow; other site 412022000071 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412022000072 Surface antigen; Region: Bac_surface_Ag; pfam01103 412022000073 rod shape-determining protein MreB; Provisional; Region: PRK13930 412022000074 MreB and similar proteins; Region: MreB_like; cd10225 412022000075 nucleotide binding site [chemical binding]; other site 412022000076 Mg binding site [ion binding]; other site 412022000077 putative protofilament interaction site [polypeptide binding]; other site 412022000078 RodZ interaction site [polypeptide binding]; other site 412022000079 Cytochrome c; Region: Cytochrom_C; cl11414 412022000080 HD domain; Region: HD_3; pfam13023 412022000081 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 412022000082 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 412022000083 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 412022000084 substrate binding pocket [chemical binding]; other site 412022000085 aspartate-rich region 1; other site 412022000086 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 412022000087 putative dimer interface [polypeptide binding]; other site 412022000088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022000089 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412022000090 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 412022000091 C-terminal domain interface [polypeptide binding]; other site 412022000092 GSH binding site (G-site) [chemical binding]; other site 412022000093 dimer interface [polypeptide binding]; other site 412022000094 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 412022000095 N-terminal domain interface [polypeptide binding]; other site 412022000096 dimer interface [polypeptide binding]; other site 412022000097 substrate binding pocket (H-site) [chemical binding]; other site 412022000098 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 412022000099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022000100 dimer interface [polypeptide binding]; other site 412022000101 phosphorylation site [posttranslational modification] 412022000102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000103 ATP binding site [chemical binding]; other site 412022000104 Mg2+ binding site [ion binding]; other site 412022000105 G-X-G motif; other site 412022000106 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 412022000107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000108 active site 412022000109 phosphorylation site [posttranslational modification] 412022000110 intermolecular recognition site; other site 412022000111 dimerization interface [polypeptide binding]; other site 412022000112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022000113 DNA binding site [nucleotide binding] 412022000114 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022000115 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022000116 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412022000117 putative active site [active] 412022000118 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 412022000119 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 412022000120 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 412022000121 active site residue [active] 412022000122 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 412022000123 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 412022000124 conserved cys residue [active] 412022000125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000126 hypothetical protein; Provisional; Region: PRK07907 412022000127 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 412022000128 metal binding site [ion binding]; metal-binding site 412022000129 putative dimer interface [polypeptide binding]; other site 412022000130 TfoX N-terminal domain; Region: TfoX_N; pfam04993 412022000131 NnrU protein; Region: NnrU; pfam07298 412022000132 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 412022000133 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 412022000134 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 412022000135 Transposase; Region: HTH_Tnp_1; pfam01527 412022000136 HTH-like domain; Region: HTH_21; pfam13276 412022000137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000138 Integrase core domain; Region: rve; pfam00665 412022000139 Integrase core domain; Region: rve_3; pfam13683 412022000140 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 412022000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 412022000142 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 412022000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000144 putative substrate translocation pore; other site 412022000145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000146 Trehalase; Region: Trehalase; cl17346 412022000147 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 412022000148 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 412022000149 Subunit I/III interface [polypeptide binding]; other site 412022000150 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022000151 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022000152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022000153 DNA binding residues [nucleotide binding] 412022000154 dimerization interface [polypeptide binding]; other site 412022000155 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022000156 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 412022000157 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412022000158 active site 412022000159 dimer interface [polypeptide binding]; other site 412022000160 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412022000161 Ligand Binding Site [chemical binding]; other site 412022000162 Molecular Tunnel; other site 412022000163 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412022000164 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 412022000165 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 412022000166 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 412022000167 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 412022000168 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 412022000169 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 412022000170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022000171 catalytic loop [active] 412022000172 iron binding site [ion binding]; other site 412022000173 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 412022000174 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 412022000175 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 412022000176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000178 SnoaL-like domain; Region: SnoaL_2; pfam12680 412022000179 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 412022000180 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 412022000181 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 412022000182 Flavin binding site [chemical binding]; other site 412022000183 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 412022000184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022000185 active site 412022000186 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 412022000187 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 412022000188 active site 412022000189 non-prolyl cis peptide bond; other site 412022000190 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022000191 dimerization interface [polypeptide binding]; other site 412022000192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022000193 dimer interface [polypeptide binding]; other site 412022000194 phosphorylation site [posttranslational modification] 412022000195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000196 ATP binding site [chemical binding]; other site 412022000197 Mg2+ binding site [ion binding]; other site 412022000198 G-X-G motif; other site 412022000199 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022000200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000201 active site 412022000202 phosphorylation site [posttranslational modification] 412022000203 intermolecular recognition site; other site 412022000204 dimerization interface [polypeptide binding]; other site 412022000205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022000206 DNA binding site [nucleotide binding] 412022000207 MltA-interacting protein MipA; Region: MipA; cl01504 412022000208 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022000209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022000210 NAD(P) binding site [chemical binding]; other site 412022000211 active site 412022000212 MarR family; Region: MarR_2; cl17246 412022000213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022000214 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 412022000215 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 412022000216 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412022000217 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 412022000218 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 412022000219 NAD binding site [chemical binding]; other site 412022000220 catalytic residues [active] 412022000221 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 412022000222 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 412022000223 putative active site [active] 412022000224 putative metal binding site [ion binding]; other site 412022000225 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 412022000226 putative substrate binding pocket [chemical binding]; other site 412022000227 trimer interface [polypeptide binding]; other site 412022000228 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 412022000229 Helix-turn-helix domain; Region: HTH_18; pfam12833 412022000230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000231 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412022000232 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412022000233 NAD(P) binding site [chemical binding]; other site 412022000234 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022000235 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022000236 trimer interface [polypeptide binding]; other site 412022000237 eyelet of channel; other site 412022000238 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 412022000239 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412022000240 Walker A/P-loop; other site 412022000241 ATP binding site [chemical binding]; other site 412022000242 Q-loop/lid; other site 412022000243 ABC transporter signature motif; other site 412022000244 Walker B; other site 412022000245 D-loop; other site 412022000246 H-loop/switch region; other site 412022000247 TOBE domain; Region: TOBE_2; pfam08402 412022000248 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412022000249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022000250 dimer interface [polypeptide binding]; other site 412022000251 conserved gate region; other site 412022000252 ABC-ATPase subunit interface; other site 412022000253 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412022000254 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412022000255 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 412022000256 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 412022000257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000258 active site 412022000259 phosphorylation site [posttranslational modification] 412022000260 intermolecular recognition site; other site 412022000261 dimerization interface [polypeptide binding]; other site 412022000262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022000263 DNA binding site [nucleotide binding] 412022000264 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 412022000265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022000266 dimer interface [polypeptide binding]; other site 412022000267 phosphorylation site [posttranslational modification] 412022000268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000269 ATP binding site [chemical binding]; other site 412022000270 Mg2+ binding site [ion binding]; other site 412022000271 G-X-G motif; other site 412022000272 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 412022000273 MOSC domain; Region: MOSC; pfam03473 412022000274 HTH-like domain; Region: HTH_21; pfam13276 412022000275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000276 Integrase core domain; Region: rve; pfam00665 412022000277 Integrase core domain; Region: rve_3; pfam13683 412022000278 Transposase; Region: HTH_Tnp_1; pfam01527 412022000279 MASE1; Region: MASE1; pfam05231 412022000280 PAS fold; Region: PAS_3; pfam08447 412022000281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022000282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022000283 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 412022000284 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 412022000285 potential catalytic triad [active] 412022000286 conserved cys residue [active] 412022000287 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412022000288 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 412022000289 active site 412022000290 FMN binding site [chemical binding]; other site 412022000291 substrate binding site [chemical binding]; other site 412022000292 homotetramer interface [polypeptide binding]; other site 412022000293 catalytic residue [active] 412022000294 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 412022000295 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 412022000296 NAD binding site [chemical binding]; other site 412022000297 homotetramer interface [polypeptide binding]; other site 412022000298 homodimer interface [polypeptide binding]; other site 412022000299 substrate binding site [chemical binding]; other site 412022000300 active site 412022000301 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412022000302 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 412022000303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 412022000304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022000305 NAD(P) binding site [chemical binding]; other site 412022000306 active site 412022000307 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022000308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022000309 DNA-binding site [nucleotide binding]; DNA binding site 412022000310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022000311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022000312 homodimer interface [polypeptide binding]; other site 412022000313 catalytic residue [active] 412022000314 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 412022000315 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 412022000316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412022000317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412022000318 ligand binding site [chemical binding]; other site 412022000319 flexible hinge region; other site 412022000320 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 412022000321 acyl-CoA synthetase; Validated; Region: PRK08162 412022000322 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 412022000323 acyl-activating enzyme (AAE) consensus motif; other site 412022000324 putative active site [active] 412022000325 AMP binding site [chemical binding]; other site 412022000326 putative CoA binding site [chemical binding]; other site 412022000327 Cache domain; Region: Cache_1; pfam02743 412022000328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022000329 dimer interface [polypeptide binding]; other site 412022000330 putative CheW interface [polypeptide binding]; other site 412022000331 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 412022000332 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 412022000333 Outer membrane efflux protein; Region: OEP; pfam02321 412022000334 Outer membrane efflux protein; Region: OEP; pfam02321 412022000335 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 412022000336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 412022000337 DXD motif; other site 412022000338 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022000339 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022000340 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 412022000341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022000342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022000343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022000344 dimerization interface [polypeptide binding]; other site 412022000345 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 412022000346 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022000347 inhibitor-cofactor binding pocket; inhibition site 412022000348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022000349 catalytic residue [active] 412022000350 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 412022000351 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 412022000352 tetrameric interface [polypeptide binding]; other site 412022000353 NAD binding site [chemical binding]; other site 412022000354 catalytic residues [active] 412022000355 HTH-like domain; Region: HTH_21; pfam13276 412022000356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000357 Integrase core domain; Region: rve; pfam00665 412022000358 Integrase core domain; Region: rve_3; pfam13683 412022000359 Transposase; Region: HTH_Tnp_1; pfam01527 412022000360 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 412022000361 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 412022000362 active site 412022000363 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412022000364 DNA-binding site [nucleotide binding]; DNA binding site 412022000365 RNA-binding motif; other site 412022000366 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 412022000367 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 412022000368 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 412022000369 putative ligand binding site [chemical binding]; other site 412022000370 NAD binding site [chemical binding]; other site 412022000371 catalytic site [active] 412022000372 OsmC-like protein; Region: OsmC; cl00767 412022000373 CHASE3 domain; Region: CHASE3; pfam05227 412022000374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022000375 PAS domain; Region: PAS_9; pfam13426 412022000376 putative active site [active] 412022000377 heme pocket [chemical binding]; other site 412022000378 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412022000379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022000380 putative active site [active] 412022000381 heme pocket [chemical binding]; other site 412022000382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022000383 dimer interface [polypeptide binding]; other site 412022000384 phosphorylation site [posttranslational modification] 412022000385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000386 ATP binding site [chemical binding]; other site 412022000387 Mg2+ binding site [ion binding]; other site 412022000388 G-X-G motif; other site 412022000389 Response regulator receiver domain; Region: Response_reg; pfam00072 412022000390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000391 active site 412022000392 phosphorylation site [posttranslational modification] 412022000393 intermolecular recognition site; other site 412022000394 dimerization interface [polypeptide binding]; other site 412022000395 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 412022000396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000397 active site 412022000398 phosphorylation site [posttranslational modification] 412022000399 intermolecular recognition site; other site 412022000400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022000401 PAS fold; Region: PAS_3; pfam08447 412022000402 putative active site [active] 412022000403 heme pocket [chemical binding]; other site 412022000404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412022000405 Histidine kinase; Region: HisKA_3; pfam07730 412022000406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000407 ATP binding site [chemical binding]; other site 412022000408 Mg2+ binding site [ion binding]; other site 412022000409 G-X-G motif; other site 412022000410 benzoate transport; Region: 2A0115; TIGR00895 412022000411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000412 putative substrate translocation pore; other site 412022000413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000414 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 412022000415 choline dehydrogenase; Validated; Region: PRK02106 412022000416 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 412022000417 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 412022000418 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022000419 NAD(P) binding site [chemical binding]; other site 412022000420 catalytic residues [active] 412022000421 transcriptional regulator BetI; Validated; Region: PRK00767 412022000422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022000423 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 412022000424 Transposase; Region: HTH_Tnp_1; pfam01527 412022000425 HTH-like domain; Region: HTH_21; pfam13276 412022000426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000427 Integrase core domain; Region: rve; pfam00665 412022000428 Integrase core domain; Region: rve_3; pfam13683 412022000429 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022000430 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 412022000431 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 412022000432 active site 412022000433 TDP-binding site; other site 412022000434 acceptor substrate-binding pocket; other site 412022000435 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022000436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000437 putative substrate translocation pore; other site 412022000438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000439 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 412022000440 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 412022000441 Ligand binding site; other site 412022000442 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022000443 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 412022000444 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022000445 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022000446 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 412022000447 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 412022000448 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 412022000449 active site residue [active] 412022000450 serine O-acetyltransferase; Region: cysE; TIGR01172 412022000451 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 412022000452 trimer interface [polypeptide binding]; other site 412022000453 active site 412022000454 substrate binding site [chemical binding]; other site 412022000455 CoA binding site [chemical binding]; other site 412022000456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022000457 non-specific DNA binding site [nucleotide binding]; other site 412022000458 salt bridge; other site 412022000459 sequence-specific DNA binding site [nucleotide binding]; other site 412022000460 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 412022000461 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 412022000462 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022000463 catalytic residue [active] 412022000464 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 412022000465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022000466 dimerization interface [polypeptide binding]; other site 412022000467 putative DNA binding site [nucleotide binding]; other site 412022000468 putative Zn2+ binding site [ion binding]; other site 412022000469 Predicted transporter component [General function prediction only]; Region: COG2391 412022000470 Predicted transporter component [General function prediction only]; Region: COG2391 412022000471 Sulphur transport; Region: Sulf_transp; pfam04143 412022000472 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 412022000473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022000474 Coenzyme A binding pocket [chemical binding]; other site 412022000475 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 412022000476 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 412022000477 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 412022000478 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022000479 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412022000480 active site 412022000481 metal binding site [ion binding]; metal-binding site 412022000482 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 412022000483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022000484 active site 412022000485 benzoate transport; Region: 2A0115; TIGR00895 412022000486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000487 putative substrate translocation pore; other site 412022000488 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412022000489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022000490 DNA-binding site [nucleotide binding]; DNA binding site 412022000491 UTRA domain; Region: UTRA; pfam07702 412022000492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000493 putative substrate translocation pore; other site 412022000494 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 412022000495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022000496 putative DNA binding site [nucleotide binding]; other site 412022000497 putative Zn2+ binding site [ion binding]; other site 412022000498 AsnC family; Region: AsnC_trans_reg; pfam01037 412022000499 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 412022000500 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 412022000501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022000502 catalytic residue [active] 412022000503 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022000504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022000505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022000507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022000508 S-adenosylmethionine binding site [chemical binding]; other site 412022000509 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 412022000510 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412022000511 FAD binding domain; Region: FAD_binding_4; pfam01565 412022000512 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 412022000513 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412022000514 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022000515 EamA-like transporter family; Region: EamA; pfam00892 412022000516 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 412022000517 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022000518 active site 412022000519 HIGH motif; other site 412022000520 nucleotide binding site [chemical binding]; other site 412022000521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022000522 active site 412022000523 KMSKS motif; other site 412022000524 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 412022000525 tRNA binding surface [nucleotide binding]; other site 412022000526 anticodon binding site; other site 412022000527 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412022000528 Phosphoesterase family; Region: Phosphoesterase; pfam04185 412022000529 Beta-lactamase; Region: Beta-lactamase; pfam00144 412022000530 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412022000531 BCCT family transporter; Region: BCCT; pfam02028 412022000532 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022000533 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022000534 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412022000535 putative active site [active] 412022000536 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 412022000537 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 412022000538 catalytic nucleophile [active] 412022000539 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412022000540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022000541 Walker A/P-loop; other site 412022000542 ATP binding site [chemical binding]; other site 412022000543 Q-loop/lid; other site 412022000544 ABC transporter signature motif; other site 412022000545 Walker B; other site 412022000546 D-loop; other site 412022000547 H-loop/switch region; other site 412022000548 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 412022000549 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412022000550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022000551 Walker A/P-loop; other site 412022000552 ATP binding site [chemical binding]; other site 412022000553 Q-loop/lid; other site 412022000554 ABC transporter signature motif; other site 412022000555 Walker B; other site 412022000556 D-loop; other site 412022000557 H-loop/switch region; other site 412022000558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022000559 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 412022000560 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 412022000561 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 412022000562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022000563 dimer interface [polypeptide binding]; other site 412022000564 conserved gate region; other site 412022000565 putative PBP binding loops; other site 412022000566 ABC-ATPase subunit interface; other site 412022000567 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 412022000568 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 412022000569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022000570 dimer interface [polypeptide binding]; other site 412022000571 conserved gate region; other site 412022000572 putative PBP binding loops; other site 412022000573 ABC-ATPase subunit interface; other site 412022000574 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 412022000575 homotetramer interface [polypeptide binding]; other site 412022000576 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 412022000577 cleavage site 412022000578 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 412022000579 SxDxEG motif; other site 412022000580 active site 412022000581 metal binding site [ion binding]; metal-binding site 412022000582 homopentamer interface [polypeptide binding]; other site 412022000583 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 412022000584 active site 412022000585 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 412022000586 heterodimer interface [polypeptide binding]; other site 412022000587 multimer interface [polypeptide binding]; other site 412022000588 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 412022000589 active site 412022000590 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 412022000591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022000592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022000593 dimerization interface [polypeptide binding]; other site 412022000594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022000595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022000596 metal binding site [ion binding]; metal-binding site 412022000597 active site 412022000598 I-site; other site 412022000599 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 412022000600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022000601 S-adenosylmethionine binding site [chemical binding]; other site 412022000602 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 412022000603 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412022000604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 412022000605 putative transporter; Provisional; Region: PRK11021 412022000606 Transposase; Region: HTH_Tnp_1; pfam01527 412022000607 HTH-like domain; Region: HTH_21; pfam13276 412022000608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000609 Integrase core domain; Region: rve; pfam00665 412022000610 Integrase core domain; Region: rve_3; pfam13683 412022000611 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 412022000612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022000613 ATP binding site [chemical binding]; other site 412022000614 putative Mg++ binding site [ion binding]; other site 412022000615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022000616 nucleotide binding region [chemical binding]; other site 412022000617 ATP-binding site [chemical binding]; other site 412022000618 DEAD/H associated; Region: DEAD_assoc; pfam08494 412022000619 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 412022000620 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 412022000621 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 412022000622 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 412022000623 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 412022000624 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 412022000625 putative active site [active] 412022000626 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412022000627 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 412022000628 Walker A/P-loop; other site 412022000629 ATP binding site [chemical binding]; other site 412022000630 Q-loop/lid; other site 412022000631 ABC transporter signature motif; other site 412022000632 Walker B; other site 412022000633 D-loop; other site 412022000634 H-loop/switch region; other site 412022000635 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 412022000636 putative acyl-acceptor binding pocket; other site 412022000637 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 412022000638 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 412022000639 linker region; other site 412022000640 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022000641 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 412022000642 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 412022000643 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 412022000644 catalytic residue [active] 412022000645 Transposase; Region: HTH_Tnp_1; pfam01527 412022000646 HTH-like domain; Region: HTH_21; pfam13276 412022000647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000648 Integrase core domain; Region: rve; pfam00665 412022000649 Integrase core domain; Region: rve_3; pfam13683 412022000650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022000651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022000652 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 412022000653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412022000654 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 412022000655 EamA-like transporter family; Region: EamA; pfam00892 412022000656 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022000657 Uncharacterized conserved protein [Function unknown]; Region: COG1739 412022000658 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 412022000659 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 412022000660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022000661 RNA polymerase factor sigma-70; Validated; Region: PRK09047 412022000662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022000663 DNA binding residues [nucleotide binding] 412022000664 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 412022000665 acyl-CoA synthetase; Validated; Region: PRK05850 412022000666 acyl-activating enzyme (AAE) consensus motif; other site 412022000667 active site 412022000668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022000669 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 412022000670 active site 412022000671 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022000672 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 412022000673 active site 412022000674 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022000675 Biofilm formation and stress response factor; Region: BsmA; pfam10014 412022000676 Condensation domain; Region: Condensation; pfam00668 412022000677 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022000678 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022000679 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022000680 acyl-activating enzyme (AAE) consensus motif; other site 412022000681 AMP binding site [chemical binding]; other site 412022000682 Condensation domain; Region: Condensation; pfam00668 412022000683 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022000684 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022000685 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022000686 acyl-activating enzyme (AAE) consensus motif; other site 412022000687 AMP binding site [chemical binding]; other site 412022000688 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022000689 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022000690 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 412022000691 active site 412022000692 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412022000693 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 412022000694 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 412022000695 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 412022000696 KR domain; Region: KR; pfam08659 412022000697 putative NADP binding site [chemical binding]; other site 412022000698 active site 412022000699 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022000700 Transposase; Region: HTH_Tnp_1; pfam01527 412022000701 HTH-like domain; Region: HTH_21; pfam13276 412022000702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000703 Integrase core domain; Region: rve; pfam00665 412022000704 Integrase core domain; Region: rve_3; pfam13683 412022000705 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 412022000706 Transposase domain (DUF772); Region: DUF772; pfam05598 412022000707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022000708 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022000709 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 412022000710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 412022000712 MbtH-like protein; Region: MbtH; pfam03621 412022000713 Condensation domain; Region: Condensation; pfam00668 412022000714 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022000715 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022000716 acyl-activating enzyme (AAE) consensus motif; other site 412022000717 AMP binding site [chemical binding]; other site 412022000718 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022000719 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 412022000720 hypothetical protein; Provisional; Region: PRK09040 412022000721 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022000722 ligand binding site [chemical binding]; other site 412022000723 Domain of unknown function (DUF802); Region: DUF802; pfam05650 412022000724 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 412022000725 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 412022000726 Peptidase M66; Region: Peptidase_M66; pfam10462 412022000727 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 412022000728 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 412022000729 dimer interface [polypeptide binding]; other site 412022000730 active site 412022000731 metal binding site [ion binding]; metal-binding site 412022000732 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 412022000733 Prostaglandin dehydrogenases; Region: PGDH; cd05288 412022000734 NAD(P) binding site [chemical binding]; other site 412022000735 substrate binding site [chemical binding]; other site 412022000736 dimer interface [polypeptide binding]; other site 412022000737 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022000738 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022000739 short chain dehydrogenase; Provisional; Region: PRK12937 412022000740 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 412022000741 NADP binding site [chemical binding]; other site 412022000742 homodimer interface [polypeptide binding]; other site 412022000743 active site 412022000744 substrate binding site [chemical binding]; other site 412022000745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022000746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022000747 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 412022000748 putative effector binding pocket; other site 412022000749 putative dimerization interface [polypeptide binding]; other site 412022000750 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 412022000751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022000752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022000753 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022000754 dimerization interface [polypeptide binding]; other site 412022000755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022000756 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022000757 putative substrate translocation pore; other site 412022000758 allantoate amidohydrolase; Reviewed; Region: PRK12893 412022000759 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 412022000760 active site 412022000761 metal binding site [ion binding]; metal-binding site 412022000762 dimer interface [polypeptide binding]; other site 412022000763 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 412022000764 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 412022000765 active site 412022000766 Zn binding site [ion binding]; other site 412022000767 GTP cyclohydrolase I; Reviewed; Region: PRK12606 412022000768 GTP cyclohydrolase I; Provisional; Region: PLN03044 412022000769 active site 412022000770 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 412022000771 NMT1-like family; Region: NMT1_2; pfam13379 412022000772 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 412022000773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000774 active site 412022000775 phosphorylation site [posttranslational modification] 412022000776 intermolecular recognition site; other site 412022000777 dimerization interface [polypeptide binding]; other site 412022000778 ANTAR domain; Region: ANTAR; pfam03861 412022000779 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 412022000780 active site 412022000781 SAM binding site [chemical binding]; other site 412022000782 homodimer interface [polypeptide binding]; other site 412022000783 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 412022000784 nitrite reductase subunit NirD; Provisional; Region: PRK14989 412022000785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022000786 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412022000787 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022000788 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 412022000789 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 412022000790 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 412022000791 [4Fe-4S] binding site [ion binding]; other site 412022000792 molybdopterin cofactor binding site; other site 412022000793 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 412022000794 molybdopterin cofactor binding site; other site 412022000795 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 412022000796 Flavodoxin; Region: Flavodoxin_1; pfam00258 412022000797 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 412022000798 FAD binding pocket [chemical binding]; other site 412022000799 FAD binding motif [chemical binding]; other site 412022000800 catalytic residues [active] 412022000801 NAD binding pocket [chemical binding]; other site 412022000802 phosphate binding motif [ion binding]; other site 412022000803 beta-alpha-beta structure motif; other site 412022000804 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412022000805 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412022000806 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412022000807 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412022000808 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412022000809 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 412022000810 N- and C-terminal domain interface [polypeptide binding]; other site 412022000811 D-xylulose kinase; Region: XylB; TIGR01312 412022000812 active site 412022000813 MgATP binding site [chemical binding]; other site 412022000814 catalytic site [active] 412022000815 metal binding site [ion binding]; metal-binding site 412022000816 xylulose binding site [chemical binding]; other site 412022000817 homodimer interface [polypeptide binding]; other site 412022000818 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022000819 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 412022000820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000822 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 412022000823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022000824 Walker A/P-loop; other site 412022000825 ATP binding site [chemical binding]; other site 412022000826 Q-loop/lid; other site 412022000827 ABC transporter signature motif; other site 412022000828 Walker B; other site 412022000829 D-loop; other site 412022000830 H-loop/switch region; other site 412022000831 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 412022000832 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 412022000833 inhibitor binding site; inhibition site 412022000834 catalytic Zn binding site [ion binding]; other site 412022000835 structural Zn binding site [ion binding]; other site 412022000836 NADP binding site [chemical binding]; other site 412022000837 tetramer interface [polypeptide binding]; other site 412022000838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 412022000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022000840 dimer interface [polypeptide binding]; other site 412022000841 conserved gate region; other site 412022000842 putative PBP binding loops; other site 412022000843 ABC-ATPase subunit interface; other site 412022000844 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 412022000845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 412022000846 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 412022000847 Electron transfer DM13; Region: DM13; pfam10517 412022000848 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412022000849 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412022000850 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 412022000851 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 412022000852 Cl binding site [ion binding]; other site 412022000853 oligomer interface [polypeptide binding]; other site 412022000854 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 412022000855 dimer interface [polypeptide binding]; other site 412022000856 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 412022000857 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 412022000858 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 412022000859 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 412022000860 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 412022000861 putative cation:proton antiport protein; Provisional; Region: PRK10669 412022000862 TrkA-N domain; Region: TrkA_N; pfam02254 412022000863 short chain dehydrogenase; Provisional; Region: PRK07074 412022000864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022000865 NAD(P) binding site [chemical binding]; other site 412022000866 active site 412022000867 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 412022000868 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 412022000869 ligand binding site [chemical binding]; other site 412022000870 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412022000871 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412022000872 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412022000873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 412022000874 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 412022000875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 412022000876 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 412022000877 Phage integrase protein; Region: DUF3701; pfam12482 412022000878 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 412022000879 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 412022000880 Int/Topo IB signature motif; other site 412022000881 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412022000882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022000883 S-adenosylmethionine binding site [chemical binding]; other site 412022000884 FOG: WD40 repeat [General function prediction only]; Region: COG2319 412022000885 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 412022000886 structural tetrad; other site 412022000887 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 412022000888 structural tetrad; other site 412022000889 FOG: WD40 repeat [General function prediction only]; Region: COG2319 412022000890 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 412022000891 dimerization interface [polypeptide binding]; other site 412022000892 active site 412022000893 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022000894 multidrug efflux protein; Reviewed; Region: PRK09579 412022000895 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412022000896 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022000897 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022000898 Predicted transcriptional regulator [Transcription]; Region: COG2345 412022000899 MarR family; Region: MarR_2; pfam12802 412022000900 Transcriptional regulator PadR-like family; Region: PadR; cl17335 412022000901 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 412022000902 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 412022000903 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022000904 active site 412022000905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022000906 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 412022000907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022000908 Walker A motif; other site 412022000909 ATP binding site [chemical binding]; other site 412022000910 Walker B motif; other site 412022000911 arginine finger; other site 412022000912 Peptidase family M41; Region: Peptidase_M41; pfam01434 412022000913 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 412022000914 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 412022000915 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 412022000916 putative deacylase active site [active] 412022000917 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 412022000918 Outer membrane efflux protein; Region: OEP; pfam02321 412022000919 Outer membrane efflux protein; Region: OEP; pfam02321 412022000920 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022000921 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 412022000922 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022000923 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 412022000924 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 412022000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022000926 active site 412022000927 phosphorylation site [posttranslational modification] 412022000928 intermolecular recognition site; other site 412022000929 dimerization interface [polypeptide binding]; other site 412022000930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022000931 DNA binding site [nucleotide binding] 412022000932 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 412022000933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022000934 dimerization interface [polypeptide binding]; other site 412022000935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022000936 dimer interface [polypeptide binding]; other site 412022000937 phosphorylation site [posttranslational modification] 412022000938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022000939 ATP binding site [chemical binding]; other site 412022000940 Mg2+ binding site [ion binding]; other site 412022000941 G-X-G motif; other site 412022000942 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022000943 Transposase; Region: HTH_Tnp_1; pfam01527 412022000944 HTH-like domain; Region: HTH_21; pfam13276 412022000945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022000946 Integrase core domain; Region: rve; pfam00665 412022000947 Integrase core domain; Region: rve_3; pfam13683 412022000948 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 412022000949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022000950 active site 412022000951 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 412022000952 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 412022000953 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 412022000954 putative ligand binding site [chemical binding]; other site 412022000955 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412022000956 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412022000957 Walker A/P-loop; other site 412022000958 ATP binding site [chemical binding]; other site 412022000959 Q-loop/lid; other site 412022000960 ABC transporter signature motif; other site 412022000961 Walker B; other site 412022000962 D-loop; other site 412022000963 H-loop/switch region; other site 412022000964 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412022000965 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 412022000966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022000967 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022000968 TM-ABC transporter signature motif; other site 412022000969 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 412022000970 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022000971 N-terminal plug; other site 412022000972 ligand-binding site [chemical binding]; other site 412022000973 fec operon regulator FecR; Reviewed; Region: PRK09774 412022000974 FecR protein; Region: FecR; pfam04773 412022000975 RNA polymerase sigma factor; Provisional; Region: PRK12528 412022000976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022000977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022000978 DNA binding residues [nucleotide binding] 412022000979 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 412022000980 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 412022000981 YceI-like domain; Region: YceI; pfam04264 412022000982 RNA polymerase sigma factor; Provisional; Region: PRK12547 412022000983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022000984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022000985 DNA binding residues [nucleotide binding] 412022000986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022000987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022000988 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 412022000989 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 412022000990 CAAX protease self-immunity; Region: Abi; cl00558 412022000991 MarC family integral membrane protein; Region: MarC; cl00919 412022000992 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022000993 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 412022000994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022000995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022000996 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022000997 putative effector binding pocket; other site 412022000998 dimerization interface [polypeptide binding]; other site 412022000999 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 412022001000 HPP family; Region: HPP; pfam04982 412022001001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 412022001002 MarR family; Region: MarR_2; pfam12802 412022001003 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 412022001004 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 412022001005 Cl- selectivity filter; other site 412022001006 Cl- binding residues [ion binding]; other site 412022001007 pore gating glutamate residue; other site 412022001008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 412022001009 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022001010 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 412022001011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022001012 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001013 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001014 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022001015 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022001016 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 412022001017 active site 412022001018 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 412022001019 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 412022001020 putative NADP binding site [chemical binding]; other site 412022001021 KR domain; Region: KR; pfam08659 412022001022 active site 412022001023 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001024 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022001025 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 412022001026 active site 412022001027 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001028 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001029 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022001030 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 412022001031 active site 412022001032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022001033 Methyltransferase domain; Region: Methyltransf_12; pfam08242 412022001034 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412022001035 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001036 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022001037 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 412022001038 active site 412022001039 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001040 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022001041 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022001042 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 412022001043 active site 412022001044 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412022001045 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412022001046 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412022001047 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 412022001048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022001049 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022001050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022001051 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 412022001052 substrate binding site [chemical binding]; other site 412022001053 oxyanion hole (OAH) forming residues; other site 412022001054 trimer interface [polypeptide binding]; other site 412022001055 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022001056 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 412022001057 substrate binding site [chemical binding]; other site 412022001058 oxyanion hole (OAH) forming residues; other site 412022001059 trimer interface [polypeptide binding]; other site 412022001060 acyl carrier protein; Validated; Region: PRK07117 412022001061 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 412022001062 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412022001063 dimer interface [polypeptide binding]; other site 412022001064 active site 412022001065 TPR repeat; Region: TPR_11; pfam13414 412022001066 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 412022001067 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 412022001068 iron-sulfur cluster [ion binding]; other site 412022001069 [2Fe-2S] cluster binding site [ion binding]; other site 412022001070 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 412022001071 hydrophobic ligand binding site; other site 412022001072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022001073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022001074 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022001075 S-adenosylmethionine binding site [chemical binding]; other site 412022001076 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 412022001077 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 412022001078 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 412022001079 tetramer interface [polypeptide binding]; other site 412022001080 heme binding pocket [chemical binding]; other site 412022001081 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412022001082 LytTr DNA-binding domain; Region: LytTR; smart00850 412022001083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022001084 active site 412022001085 phosphorylation site [posttranslational modification] 412022001086 intermolecular recognition site; other site 412022001087 dimerization interface [polypeptide binding]; other site 412022001088 Transposase; Region: HTH_Tnp_1; pfam01527 412022001089 HTH-like domain; Region: HTH_21; pfam13276 412022001090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022001091 Integrase core domain; Region: rve; pfam00665 412022001092 Integrase core domain; Region: rve_3; pfam13683 412022001093 Histidine kinase; Region: His_kinase; pfam06580 412022001094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022001095 ATP binding site [chemical binding]; other site 412022001096 Mg2+ binding site [ion binding]; other site 412022001097 G-X-G motif; other site 412022001098 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 412022001099 Uncharacterized conserved protein [Function unknown]; Region: COG3791 412022001100 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 412022001101 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412022001102 putative active site [active] 412022001103 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 412022001104 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022001105 Walker A/P-loop; other site 412022001106 ATP binding site [chemical binding]; other site 412022001107 Q-loop/lid; other site 412022001108 ABC transporter signature motif; other site 412022001109 Walker B; other site 412022001110 D-loop; other site 412022001111 H-loop/switch region; other site 412022001112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022001113 dimer interface [polypeptide binding]; other site 412022001114 conserved gate region; other site 412022001115 putative PBP binding loops; other site 412022001116 ABC-ATPase subunit interface; other site 412022001117 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022001118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022001119 dimer interface [polypeptide binding]; other site 412022001120 conserved gate region; other site 412022001121 putative PBP binding loops; other site 412022001122 ABC-ATPase subunit interface; other site 412022001123 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 412022001124 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001125 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001126 trimer interface [polypeptide binding]; other site 412022001127 eyelet of channel; other site 412022001128 Predicted membrane protein [Function unknown]; Region: COG2259 412022001129 Cytochrome c; Region: Cytochrom_C; pfam00034 412022001130 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412022001131 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412022001132 Cytochrome c; Region: Cytochrom_C; pfam00034 412022001133 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 412022001134 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 412022001135 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 412022001136 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 412022001137 active site 412022001138 catalytic triad [active] 412022001139 magnesium-transporting ATPase; Provisional; Region: PRK15122 412022001140 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 412022001141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412022001142 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 412022001143 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412022001144 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 412022001145 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 412022001146 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022001147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022001148 DNA-binding site [nucleotide binding]; DNA binding site 412022001149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022001150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022001151 homodimer interface [polypeptide binding]; other site 412022001152 catalytic residue [active] 412022001153 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 412022001154 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 412022001155 putative molybdopterin cofactor binding site [chemical binding]; other site 412022001156 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 412022001157 putative molybdopterin cofactor binding site; other site 412022001158 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 412022001159 Predicted membrane protein [Function unknown]; Region: COG4682 412022001160 yiaA/B two helix domain; Region: YiaAB; pfam05360 412022001161 yiaA/B two helix domain; Region: YiaAB; pfam05360 412022001162 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 412022001163 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 412022001164 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 412022001165 Cupin; Region: Cupin_1; smart00835 412022001166 Cupin; Region: Cupin_1; smart00835 412022001167 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 412022001168 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 412022001169 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 412022001170 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 412022001171 catalytic triad [active] 412022001172 putative active site [active] 412022001173 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 412022001174 Autotransporter beta-domain; Region: Autotransporter; smart00869 412022001175 PAAR motif; Region: PAAR_motif; pfam05488 412022001176 RHS Repeat; Region: RHS_repeat; cl11982 412022001177 RHS Repeat; Region: RHS_repeat; pfam05593 412022001178 RHS Repeat; Region: RHS_repeat; cl11982 412022001179 RHS Repeat; Region: RHS_repeat; pfam05593 412022001180 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 412022001181 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 412022001182 RHS Repeat; Region: RHS_repeat; pfam05593 412022001183 RHS Repeat; Region: RHS_repeat; cl11982 412022001184 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 412022001185 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 412022001186 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 412022001187 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022001188 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022001189 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 412022001190 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022001191 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022001192 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 412022001193 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 412022001194 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 412022001195 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 412022001196 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412022001197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022001198 dimer interface [polypeptide binding]; other site 412022001199 conserved gate region; other site 412022001200 putative PBP binding loops; other site 412022001201 ABC-ATPase subunit interface; other site 412022001202 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 412022001203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022001204 dimer interface [polypeptide binding]; other site 412022001205 conserved gate region; other site 412022001206 putative PBP binding loops; other site 412022001207 ABC-ATPase subunit interface; other site 412022001208 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412022001209 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022001210 Walker A/P-loop; other site 412022001211 ATP binding site [chemical binding]; other site 412022001212 Q-loop/lid; other site 412022001213 ABC transporter signature motif; other site 412022001214 Walker B; other site 412022001215 D-loop; other site 412022001216 H-loop/switch region; other site 412022001217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412022001218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022001219 Walker A/P-loop; other site 412022001220 ATP binding site [chemical binding]; other site 412022001221 Q-loop/lid; other site 412022001222 ABC transporter signature motif; other site 412022001223 Walker B; other site 412022001224 D-loop; other site 412022001225 H-loop/switch region; other site 412022001226 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022001227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022001228 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 412022001229 substrate binding pocket [chemical binding]; other site 412022001230 dimerization interface [polypeptide binding]; other site 412022001231 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 412022001232 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412022001233 Peptidase family M23; Region: Peptidase_M23; pfam01551 412022001234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022001235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022001236 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 412022001237 putative dimerization interface [polypeptide binding]; other site 412022001238 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001239 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001240 trimer interface [polypeptide binding]; other site 412022001241 eyelet of channel; other site 412022001242 OpgC protein; Region: OpgC_C; pfam10129 412022001243 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 412022001244 Putative esterase; Region: Esterase; pfam00756 412022001245 ornithine cyclodeaminase; Validated; Region: PRK07340 412022001246 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 412022001247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022001248 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412022001249 Ion channel; Region: Ion_trans_2; pfam07885 412022001250 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 412022001251 TrkA-N domain; Region: TrkA_N; pfam02254 412022001252 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412022001253 hydroxyglutarate oxidase; Provisional; Region: PRK11728 412022001254 BetR domain; Region: BetR; pfam08667 412022001255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022001256 active site 412022001257 phosphorylation site [posttranslational modification] 412022001258 intermolecular recognition site; other site 412022001259 dimerization interface [polypeptide binding]; other site 412022001260 Family description; Region: UvrD_C_2; pfam13538 412022001261 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 412022001262 Tar ligand binding domain homologue; Region: TarH; pfam02203 412022001263 dimer interface [polypeptide binding]; other site 412022001264 ligand binding site [chemical binding]; other site 412022001265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022001266 dimerization interface [polypeptide binding]; other site 412022001267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022001268 dimer interface [polypeptide binding]; other site 412022001269 putative CheW interface [polypeptide binding]; other site 412022001270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001271 putative substrate translocation pore; other site 412022001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001273 putative substrate translocation pore; other site 412022001274 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 412022001275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022001276 Coenzyme A binding pocket [chemical binding]; other site 412022001277 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 412022001278 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412022001279 DNA binding residues [nucleotide binding] 412022001280 putative dimer interface [polypeptide binding]; other site 412022001281 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 412022001282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022001283 substrate binding pocket [chemical binding]; other site 412022001284 membrane-bound complex binding site; other site 412022001285 hinge residues; other site 412022001286 YhhN-like protein; Region: YhhN; pfam07947 412022001287 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 412022001288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 412022001289 short chain dehydrogenase; Provisional; Region: PRK07832 412022001290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022001291 NAD(P) binding site [chemical binding]; other site 412022001292 active site 412022001293 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 412022001294 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 412022001295 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022001296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001297 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022001298 putative substrate translocation pore; other site 412022001299 Transposase; Region: HTH_Tnp_1; pfam01527 412022001300 HTH-like domain; Region: HTH_21; pfam13276 412022001301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022001302 Integrase core domain; Region: rve; pfam00665 412022001303 Integrase core domain; Region: rve_3; pfam13683 412022001304 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 412022001305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022001306 Predicted transcriptional regulator [Transcription]; Region: COG1959 412022001307 Transcriptional regulator; Region: Rrf2; pfam02082 412022001308 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 412022001309 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 412022001310 methionine gamma-lyase; Validated; Region: PRK07049 412022001311 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412022001312 homodimer interface [polypeptide binding]; other site 412022001313 substrate-cofactor binding pocket; other site 412022001314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022001315 catalytic residue [active] 412022001316 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022001317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022001318 dimerization interface [polypeptide binding]; other site 412022001319 putative DNA binding site [nucleotide binding]; other site 412022001320 putative Zn2+ binding site [ion binding]; other site 412022001321 AsnC family; Region: AsnC_trans_reg; pfam01037 412022001322 amidase; Provisional; Region: PRK07486 412022001323 Amidase; Region: Amidase; cl11426 412022001324 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022001325 Ligand Binding Site [chemical binding]; other site 412022001326 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 412022001327 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 412022001328 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022001329 ligand binding site [chemical binding]; other site 412022001330 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 412022001331 trimer interface [polypeptide binding]; other site 412022001332 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 412022001333 trimer interface [polypeptide binding]; other site 412022001334 Haemagglutinin; Region: HIM; pfam05662 412022001335 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 412022001336 trimer interface [polypeptide binding]; other site 412022001337 Haemagglutinin; Region: HIM; pfam05662 412022001338 Haemagglutinin; Region: HIM; pfam05662 412022001339 YadA-like C-terminal region; Region: YadA; pfam03895 412022001340 benzoate transport; Region: 2A0115; TIGR00895 412022001341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001342 putative substrate translocation pore; other site 412022001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001344 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 412022001345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022001346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022001347 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 412022001348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412022001349 active site 412022001350 metal binding site [ion binding]; metal-binding site 412022001351 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 412022001352 putative active site [active] 412022001353 putative metal binding site [ion binding]; other site 412022001354 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022001355 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 412022001356 NAD(P) binding site [chemical binding]; other site 412022001357 catalytic residues [active] 412022001358 L-aspartate dehydrogenase; Provisional; Region: PRK13303 412022001359 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 412022001360 Domain of unknown function DUF108; Region: DUF108; pfam01958 412022001361 hypothetical protein; Provisional; Region: PRK07064 412022001362 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022001363 PYR/PP interface [polypeptide binding]; other site 412022001364 dimer interface [polypeptide binding]; other site 412022001365 TPP binding site [chemical binding]; other site 412022001366 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022001367 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 412022001368 TPP-binding site [chemical binding]; other site 412022001369 short chain dehydrogenase; Provisional; Region: PRK07062 412022001370 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 412022001371 putative NAD(P) binding site [chemical binding]; other site 412022001372 putative active site [active] 412022001373 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022001374 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022001375 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022001376 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022001377 Cupin domain; Region: Cupin_2; pfam07883 412022001378 short chain dehydrogenase; Provisional; Region: PRK12939 412022001379 classical (c) SDRs; Region: SDR_c; cd05233 412022001380 NAD(P) binding site [chemical binding]; other site 412022001381 active site 412022001382 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 412022001383 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 412022001384 [2Fe-2S] cluster binding site [ion binding]; other site 412022001385 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 412022001386 hydrophobic ligand binding site; other site 412022001387 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 412022001388 [2Fe-2S] cluster binding site [ion binding]; other site 412022001389 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001390 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001391 trimer interface [polypeptide binding]; other site 412022001392 eyelet of channel; other site 412022001393 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022001394 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022001395 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022001396 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 412022001397 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 412022001398 putative FMN binding site [chemical binding]; other site 412022001399 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 412022001400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022001401 putative active site [active] 412022001402 putative metal binding site [ion binding]; other site 412022001403 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 412022001404 MgtC family; Region: MgtC; pfam02308 412022001405 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 412022001406 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022001407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022001408 DNA binding residues [nucleotide binding] 412022001409 dimerization interface [polypeptide binding]; other site 412022001410 Autoinducer synthetase; Region: Autoind_synth; cl17404 412022001411 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 412022001412 NADH/NADPH cofactor binding site [chemical binding]; other site 412022001413 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 412022001414 dimerization interface [polypeptide binding]; other site 412022001415 active site 412022001416 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 412022001417 FOG: CBS domain [General function prediction only]; Region: COG0517 412022001418 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022001419 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 412022001420 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412022001421 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001422 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001423 trimer interface [polypeptide binding]; other site 412022001424 eyelet of channel; other site 412022001425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022001426 putative DNA binding site [nucleotide binding]; other site 412022001427 dimerization interface [polypeptide binding]; other site 412022001428 putative Zn2+ binding site [ion binding]; other site 412022001429 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412022001430 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 412022001431 FMN binding site [chemical binding]; other site 412022001432 active site 412022001433 substrate binding site [chemical binding]; other site 412022001434 catalytic residue [active] 412022001435 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412022001436 Coenzyme A binding pocket [chemical binding]; other site 412022001437 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022001438 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001439 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001440 eyelet of channel; other site 412022001441 trimer interface [polypeptide binding]; other site 412022001442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022001443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022001444 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 412022001445 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 412022001446 hypothetical protein; Provisional; Region: PRK07481 412022001447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022001448 inhibitor-cofactor binding pocket; inhibition site 412022001449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022001450 catalytic residue [active] 412022001451 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022001452 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022001453 NAD(P) binding site [chemical binding]; other site 412022001454 catalytic residues [active] 412022001455 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022001456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022001457 DNA binding residues [nucleotide binding] 412022001458 dimerization interface [polypeptide binding]; other site 412022001459 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 412022001460 classical (c) SDRs; Region: SDR_c; cd05233 412022001461 NAD(P) binding site [chemical binding]; other site 412022001462 active site 412022001463 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 412022001464 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412022001465 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412022001466 active site 412022001467 catalytic tetrad [active] 412022001468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022001469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022001470 dimerization interface [polypeptide binding]; other site 412022001471 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 412022001472 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 412022001473 catalytic residues [active] 412022001474 transcriptional regulator; Provisional; Region: PRK10632 412022001475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022001476 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022001477 putative effector binding pocket; other site 412022001478 dimerization interface [polypeptide binding]; other site 412022001479 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 412022001480 flagellar capping protein; Reviewed; Region: fliD; PRK08032 412022001481 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 412022001482 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 412022001483 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 412022001484 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 412022001485 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 412022001486 Transposase; Region: HTH_Tnp_1; pfam01527 412022001487 HTH-like domain; Region: HTH_21; pfam13276 412022001488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022001489 Integrase core domain; Region: rve; pfam00665 412022001490 Integrase core domain; Region: rve_3; pfam13683 412022001491 Haemagglutinin; Region: HIM; pfam05662 412022001492 YadA-like C-terminal region; Region: YadA; pfam03895 412022001493 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 412022001494 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 412022001495 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 412022001496 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 412022001497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412022001498 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412022001499 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412022001500 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412022001501 carboxyltransferase (CT) interaction site; other site 412022001502 biotinylation site [posttranslational modification]; other site 412022001503 enoyl-CoA hydratase; Provisional; Region: PRK05995 412022001504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022001505 substrate binding site [chemical binding]; other site 412022001506 oxyanion hole (OAH) forming residues; other site 412022001507 trimer interface [polypeptide binding]; other site 412022001508 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 412022001509 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 412022001510 isovaleryl-CoA dehydrogenase; Region: PLN02519 412022001511 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 412022001512 substrate binding site [chemical binding]; other site 412022001513 FAD binding site [chemical binding]; other site 412022001514 catalytic base [active] 412022001515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022001516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022001517 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 412022001518 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 412022001519 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 412022001520 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 412022001521 Multicopper oxidase; Region: Cu-oxidase; pfam00394 412022001522 Cytochrome c; Region: Cytochrom_C; pfam00034 412022001523 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 412022001524 [2Fe-2S] cluster binding site [ion binding]; other site 412022001525 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 412022001526 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 412022001527 alpha subunit interface [polypeptide binding]; other site 412022001528 active site 412022001529 substrate binding site [chemical binding]; other site 412022001530 Fe binding site [ion binding]; other site 412022001531 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 412022001532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 412022001533 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022001534 catalytic residue [active] 412022001535 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 412022001536 Cupin-like domain; Region: Cupin_8; pfam13621 412022001537 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 412022001538 benzoate transport; Region: 2A0115; TIGR00895 412022001539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001540 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412022001541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022001542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022001543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022001544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 412022001545 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 412022001546 dimer interface [polypeptide binding]; other site 412022001547 phosphorylation site [posttranslational modification] 412022001548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022001549 ATP binding site [chemical binding]; other site 412022001550 Mg2+ binding site [ion binding]; other site 412022001551 G-X-G motif; other site 412022001552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022001553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022001554 active site 412022001555 phosphorylation site [posttranslational modification] 412022001556 intermolecular recognition site; other site 412022001557 dimerization interface [polypeptide binding]; other site 412022001558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022001559 DNA binding site [nucleotide binding] 412022001560 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 412022001561 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 412022001562 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 412022001563 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 412022001564 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 412022001565 FAD binding pocket [chemical binding]; other site 412022001566 FAD binding motif [chemical binding]; other site 412022001567 catalytic residues [active] 412022001568 NAD binding pocket [chemical binding]; other site 412022001569 phosphate binding motif [ion binding]; other site 412022001570 beta-alpha-beta structure motif; other site 412022001571 ApbE family; Region: ApbE; pfam02424 412022001572 ApbE family; Region: ApbE; pfam02424 412022001573 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 412022001574 aldehyde dehydrogenase family 7 member; Region: PLN02315 412022001575 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 412022001576 tetrameric interface [polypeptide binding]; other site 412022001577 NAD binding site [chemical binding]; other site 412022001578 catalytic residues [active] 412022001579 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022001580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022001581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022001582 homodimer interface [polypeptide binding]; other site 412022001583 catalytic residue [active] 412022001584 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 412022001585 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022001586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022001587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022001588 dimerization interface [polypeptide binding]; other site 412022001589 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 412022001590 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 412022001591 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 412022001592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022001593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022001594 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 412022001595 putative active site [active] 412022001596 catalytic site [active] 412022001597 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 412022001598 putative active site [active] 412022001599 catalytic site [active] 412022001600 PLD-like domain; Region: PLDc_2; pfam13091 412022001601 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412022001602 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 412022001603 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412022001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001605 D-galactonate transporter; Region: 2A0114; TIGR00893 412022001606 putative substrate translocation pore; other site 412022001607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001608 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 412022001609 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 412022001610 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 412022001611 Transcriptional regulators [Transcription]; Region: GntR; COG1802 412022001612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022001613 DNA-binding site [nucleotide binding]; DNA binding site 412022001614 FCD domain; Region: FCD; pfam07729 412022001615 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 412022001616 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 412022001617 metal binding site [ion binding]; metal-binding site 412022001618 substrate binding pocket [chemical binding]; other site 412022001619 putative oxidoreductase; Provisional; Region: PRK10083 412022001620 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 412022001621 putative NAD(P) binding site [chemical binding]; other site 412022001622 catalytic Zn binding site [ion binding]; other site 412022001623 structural Zn binding site [ion binding]; other site 412022001624 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 412022001625 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 412022001626 homodimer interface [polypeptide binding]; other site 412022001627 NAD binding pocket [chemical binding]; other site 412022001628 ATP binding pocket [chemical binding]; other site 412022001629 Mg binding site [ion binding]; other site 412022001630 active-site loop [active] 412022001631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022001632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022001633 hypothetical protein; Provisional; Region: PRK02399 412022001634 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 412022001635 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 412022001636 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 412022001637 putative hydrophobic ligand binding site [chemical binding]; other site 412022001638 protein interface [polypeptide binding]; other site 412022001639 gate; other site 412022001640 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 412022001641 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 412022001642 Multicopper oxidase; Region: Cu-oxidase; pfam00394 412022001643 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412022001644 Cytochrome c; Region: Cytochrom_C; pfam00034 412022001645 Uncharacterized conserved protein [Function unknown]; Region: COG1262 412022001646 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 412022001647 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 412022001648 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412022001649 Cu(I) binding site [ion binding]; other site 412022001650 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 412022001651 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412022001652 amidase catalytic site [active] 412022001653 Zn binding residues [ion binding]; other site 412022001654 substrate binding site [chemical binding]; other site 412022001655 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 412022001656 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 412022001657 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 412022001658 trimer interface [polypeptide binding]; other site 412022001659 Haemagglutinin; Region: HIM; pfam05662 412022001660 YadA-like C-terminal region; Region: YadA; pfam03895 412022001661 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 412022001662 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 412022001663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022001664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022001665 active site 412022001666 phosphorylation site [posttranslational modification] 412022001667 intermolecular recognition site; other site 412022001668 dimerization interface [polypeptide binding]; other site 412022001669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022001670 DNA binding site [nucleotide binding] 412022001671 MASE1; Region: MASE1; cl17823 412022001672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022001673 dimer interface [polypeptide binding]; other site 412022001674 phosphorylation site [posttranslational modification] 412022001675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022001676 ATP binding site [chemical binding]; other site 412022001677 G-X-G motif; other site 412022001678 Protein of unknown function (DUF770); Region: DUF770; pfam05591 412022001679 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 412022001680 Protein of unknown function (DUF877); Region: DUF877; pfam05943 412022001681 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 412022001682 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 412022001683 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 412022001684 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 412022001685 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 412022001686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022001687 Walker A motif; other site 412022001688 ATP binding site [chemical binding]; other site 412022001689 Walker B motif; other site 412022001690 arginine finger; other site 412022001691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022001692 Walker A motif; other site 412022001693 ATP binding site [chemical binding]; other site 412022001694 Walker B motif; other site 412022001695 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412022001696 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 412022001697 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022001698 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022001699 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 412022001700 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022001701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022001702 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 412022001703 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022001704 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022001705 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022001706 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022001707 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022001708 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022001709 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 412022001710 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 412022001711 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 412022001712 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 412022001713 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 412022001714 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 412022001715 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 412022001716 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 412022001717 Bacterial Ig-like domain; Region: Big_5; pfam13205 412022001718 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 412022001719 active site 412022001720 Transposase; Region: HTH_Tnp_1; pfam01527 412022001721 HTH-like domain; Region: HTH_21; pfam13276 412022001722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022001723 Integrase core domain; Region: rve; pfam00665 412022001724 Integrase core domain; Region: rve_3; pfam13683 412022001725 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 412022001726 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 412022001727 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 412022001728 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 412022001729 Flavin binding site [chemical binding]; other site 412022001730 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 412022001731 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022001732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022001733 sequence-specific DNA binding site [nucleotide binding]; other site 412022001734 salt bridge; other site 412022001735 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 412022001736 Spore germination protein; Region: Spore_permease; cl17796 412022001737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022001738 NAD(P) binding site [chemical binding]; other site 412022001739 active site 412022001740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412022001741 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 412022001742 active site residue [active] 412022001743 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 412022001744 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 412022001745 catalytic Zn binding site [ion binding]; other site 412022001746 structural Zn binding site [ion binding]; other site 412022001747 NAD(P) binding site [chemical binding]; other site 412022001748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022001749 Ligand Binding Site [chemical binding]; other site 412022001750 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022001751 Ligand Binding Site [chemical binding]; other site 412022001752 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022001753 Ligand Binding Site [chemical binding]; other site 412022001754 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022001755 Ligand Binding Site [chemical binding]; other site 412022001756 Transposase domain (DUF772); Region: DUF772; pfam05598 412022001757 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022001758 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022001759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022001760 Ligand Binding Site [chemical binding]; other site 412022001761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022001762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022001763 active site 412022001764 phosphorylation site [posttranslational modification] 412022001765 intermolecular recognition site; other site 412022001766 dimerization interface [polypeptide binding]; other site 412022001767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022001768 DNA binding residues [nucleotide binding] 412022001769 dimerization interface [polypeptide binding]; other site 412022001770 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 412022001771 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 412022001772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 412022001773 sequence-specific DNA binding site [nucleotide binding]; other site 412022001774 salt bridge; other site 412022001775 Cupin domain; Region: Cupin_2; pfam07883 412022001776 putative monooxygenase; Reviewed; Region: PRK07045 412022001777 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412022001778 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022001779 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 412022001780 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412022001781 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 412022001782 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022001783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022001784 catalytic residue [active] 412022001785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022001786 S-adenosylmethionine binding site [chemical binding]; other site 412022001787 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 412022001788 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 412022001789 substrate binding pocket [chemical binding]; other site 412022001790 active site 412022001791 iron coordination sites [ion binding]; other site 412022001792 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 412022001793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022001794 active site 412022001795 HIGH motif; other site 412022001796 nucleotide binding site [chemical binding]; other site 412022001797 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022001798 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 412022001799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022001800 S-adenosylmethionine binding site [chemical binding]; other site 412022001801 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 412022001802 putative active site pocket [active] 412022001803 dimerization interface [polypeptide binding]; other site 412022001804 putative catalytic residue [active] 412022001805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 412022001806 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 412022001807 MG2 domain; Region: A2M_N; pfam01835 412022001808 Alpha-2-macroglobulin family; Region: A2M; pfam00207 412022001809 Transglycosylase; Region: Transgly; pfam00912 412022001810 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412022001811 Response regulator receiver domain; Region: Response_reg; pfam00072 412022001812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022001813 active site 412022001814 phosphorylation site [posttranslational modification] 412022001815 intermolecular recognition site; other site 412022001816 dimerization interface [polypeptide binding]; other site 412022001817 PAS fold; Region: PAS; pfam00989 412022001818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022001819 putative active site [active] 412022001820 heme pocket [chemical binding]; other site 412022001821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022001822 ATP binding site [chemical binding]; other site 412022001823 G-X-G motif; other site 412022001824 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 412022001825 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 412022001826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412022001827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022001828 Protein of unknown function, DUF488; Region: DUF488; cl01246 412022001829 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 412022001830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022001831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022001832 homodimer interface [polypeptide binding]; other site 412022001833 catalytic residue [active] 412022001834 aromatic amino acid transporter; Provisional; Region: PRK10238 412022001835 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022001836 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 412022001837 AsnC family; Region: AsnC_trans_reg; pfam01037 412022001838 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 412022001839 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 412022001840 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 412022001841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022001842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022001843 metal binding site [ion binding]; metal-binding site 412022001844 active site 412022001845 I-site; other site 412022001846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412022001847 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 412022001848 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 412022001849 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 412022001850 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 412022001851 dimerization interface [polypeptide binding]; other site 412022001852 ligand binding site [chemical binding]; other site 412022001853 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412022001854 CoenzymeA binding site [chemical binding]; other site 412022001855 subunit interaction site [polypeptide binding]; other site 412022001856 PHB binding site; other site 412022001857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022001858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022001859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412022001860 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 412022001861 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022001862 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022001863 H-NS histone family; Region: Histone_HNS; pfam00816 412022001864 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022001865 YadA-like C-terminal region; Region: YadA; pfam03895 412022001866 Transposase; Region: HTH_Tnp_1; pfam01527 412022001867 HTH-like domain; Region: HTH_21; pfam13276 412022001868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022001869 Integrase core domain; Region: rve; pfam00665 412022001870 Integrase core domain; Region: rve_3; pfam13683 412022001871 Domain of unknown function (DUF718); Region: DUF718; cl01281 412022001872 short chain dehydrogenase; Provisional; Region: PRK08628 412022001873 classical (c) SDRs; Region: SDR_c; cd05233 412022001874 NAD(P) binding site [chemical binding]; other site 412022001875 active site 412022001876 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 412022001877 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412022001878 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 412022001879 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 412022001880 NAD binding site [chemical binding]; other site 412022001881 homotetramer interface [polypeptide binding]; other site 412022001882 homodimer interface [polypeptide binding]; other site 412022001883 active site 412022001884 Amidohydrolase; Region: Amidohydro_2; pfam04909 412022001885 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 412022001886 active site 412022001887 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 412022001888 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 412022001889 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022001890 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022001891 TM-ABC transporter signature motif; other site 412022001892 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 412022001893 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412022001894 Walker A/P-loop; other site 412022001895 ATP binding site [chemical binding]; other site 412022001896 Q-loop/lid; other site 412022001897 ABC transporter signature motif; other site 412022001898 Walker B; other site 412022001899 D-loop; other site 412022001900 H-loop/switch region; other site 412022001901 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412022001902 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 412022001903 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 412022001904 ligand binding site [chemical binding]; other site 412022001905 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022001906 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 412022001907 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022001908 Tannase and feruloyl esterase; Region: Tannase; pfam07519 412022001909 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001910 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001911 trimer interface [polypeptide binding]; other site 412022001912 eyelet of channel; other site 412022001913 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 412022001914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001915 putative substrate translocation pore; other site 412022001916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022001917 active site 412022001918 CoA binding site [chemical binding]; other site 412022001919 AMP binding site [chemical binding]; other site 412022001920 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022001921 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022001922 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022001923 NAD(P) binding site [chemical binding]; other site 412022001924 catalytic residues [active] 412022001925 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 412022001926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022001927 substrate binding site [chemical binding]; other site 412022001928 oxyanion hole (OAH) forming residues; other site 412022001929 trimer interface [polypeptide binding]; other site 412022001930 Uncharacterized conserved protein [Function unknown]; Region: COG5649 412022001931 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 412022001932 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 412022001933 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022001934 TM-ABC transporter signature motif; other site 412022001935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022001936 dimerization interface [polypeptide binding]; other site 412022001937 MarR family; Region: MarR_2; cl17246 412022001938 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022001939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022001940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 412022001941 active site 412022001942 phosphorylation site [posttranslational modification] 412022001943 intermolecular recognition site; other site 412022001944 dimerization interface [polypeptide binding]; other site 412022001945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022001946 DNA binding residues [nucleotide binding] 412022001947 dimerization interface [polypeptide binding]; other site 412022001948 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 412022001949 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 412022001950 Phosphoesterase family; Region: Phosphoesterase; pfam04185 412022001951 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 412022001952 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 412022001953 H-type lectin domain; Region: H_lectin; pfam09458 412022001954 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 412022001955 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 412022001956 putative ion selectivity filter; other site 412022001957 putative pore gating glutamate residue; other site 412022001958 Transcriptional regulators [Transcription]; Region: GntR; COG1802 412022001959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 412022001960 FCD domain; Region: FCD; pfam07729 412022001961 short chain dehydrogenase; Provisional; Region: PRK12829 412022001962 classical (c) SDRs; Region: SDR_c; cd05233 412022001963 NAD(P) binding site [chemical binding]; other site 412022001964 active site 412022001965 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 412022001966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022001967 putative substrate translocation pore; other site 412022001968 cytosine deaminase; Provisional; Region: PRK09230 412022001969 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 412022001970 active site 412022001971 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 412022001972 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 412022001973 cytosine permease; Provisional; Region: codB; PRK11017 412022001974 Na binding site [ion binding]; other site 412022001975 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 412022001976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022001977 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022001978 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022001979 trimer interface [polypeptide binding]; other site 412022001980 eyelet of channel; other site 412022001981 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022001982 transcriptional regulator; Provisional; Region: PRK10632 412022001983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022001984 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022001985 putative effector binding pocket; other site 412022001986 dimerization interface [polypeptide binding]; other site 412022001987 Fusaric acid resistance protein family; Region: FUSC; pfam04632 412022001988 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 412022001989 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 412022001990 homodimer interface [polypeptide binding]; other site 412022001991 homotetramer interface [polypeptide binding]; other site 412022001992 active site pocket [active] 412022001993 cleavage site 412022001994 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 412022001995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022001996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022001997 DNA binding residues [nucleotide binding] 412022001998 dimerization interface [polypeptide binding]; other site 412022001999 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 412022002000 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 412022002001 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022002002 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022002003 trimer interface [polypeptide binding]; other site 412022002004 eyelet of channel; other site 412022002005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022002006 Secretory lipase; Region: LIP; pfam03583 412022002007 HTH-like domain; Region: HTH_21; pfam13276 412022002008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022002009 Integrase core domain; Region: rve; pfam00665 412022002010 Integrase core domain; Region: rve_3; pfam13683 412022002011 Transposase; Region: HTH_Tnp_1; pfam01527 412022002012 Cupin domain; Region: Cupin_2; cl17218 412022002013 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 412022002014 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 412022002015 Transcriptional regulators [Transcription]; Region: FadR; COG2186 412022002016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022002017 DNA-binding site [nucleotide binding]; DNA binding site 412022002018 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 412022002019 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412022002020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 412022002021 putative aldolase; Validated; Region: PRK08130 412022002022 intersubunit interface [polypeptide binding]; other site 412022002023 active site 412022002024 Zn2+ binding site [ion binding]; other site 412022002025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022002026 D-galactonate transporter; Region: 2A0114; TIGR00893 412022002027 putative substrate translocation pore; other site 412022002028 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 412022002029 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022002030 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 412022002031 putative NAD(P) binding site [chemical binding]; other site 412022002032 active site 412022002033 putative substrate binding site [chemical binding]; other site 412022002034 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 412022002035 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 412022002036 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 412022002037 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 412022002038 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022002039 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 412022002040 conserved cys residue [active] 412022002041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022002042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022002043 dimer interface [polypeptide binding]; other site 412022002044 conserved gate region; other site 412022002045 putative PBP binding loops; other site 412022002046 ABC-ATPase subunit interface; other site 412022002047 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 412022002048 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 412022002049 Walker A/P-loop; other site 412022002050 ATP binding site [chemical binding]; other site 412022002051 Q-loop/lid; other site 412022002052 ABC transporter signature motif; other site 412022002053 Walker B; other site 412022002054 D-loop; other site 412022002055 H-loop/switch region; other site 412022002056 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 412022002057 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 412022002058 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412022002059 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 412022002060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022002061 dimerization interface [polypeptide binding]; other site 412022002062 putative DNA binding site [nucleotide binding]; other site 412022002063 putative Zn2+ binding site [ion binding]; other site 412022002064 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 412022002065 putative metal binding site [ion binding]; other site 412022002066 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 412022002067 Low molecular weight phosphatase family; Region: LMWPc; cd00115 412022002068 active site 412022002069 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 412022002070 arsenical-resistance protein; Region: acr3; TIGR00832 412022002071 Transposase; Region: HTH_Tnp_1; pfam01527 412022002072 HTH-like domain; Region: HTH_21; pfam13276 412022002073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022002074 Integrase core domain; Region: rve; pfam00665 412022002075 Integrase core domain; Region: rve_3; pfam13683 412022002076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412022002077 Bacterial Ig-like domain; Region: Big_5; pfam13205 412022002078 Integrase core domain; Region: rve; pfam00665 412022002079 Integrase core domain; Region: rve_3; pfam13683 412022002080 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 412022002081 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 412022002082 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412022002083 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022002084 active site 412022002085 metal binding site [ion binding]; metal-binding site 412022002086 HTH-like domain; Region: HTH_21; pfam13276 412022002087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022002088 Integrase core domain; Region: rve; pfam00665 412022002089 Integrase core domain; Region: rve_3; pfam13683 412022002090 Transposase; Region: HTH_Tnp_1; pfam01527 412022002091 enoyl-CoA hydratase; Provisional; Region: PRK05862 412022002092 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022002093 substrate binding site [chemical binding]; other site 412022002094 oxyanion hole (OAH) forming residues; other site 412022002095 trimer interface [polypeptide binding]; other site 412022002096 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 412022002097 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022002098 NAD(P) binding site [chemical binding]; other site 412022002099 catalytic residues [active] 412022002100 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 412022002101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022002102 dimer interface [polypeptide binding]; other site 412022002103 active site 412022002104 enoyl-CoA hydratase; Provisional; Region: PRK08140 412022002105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022002106 substrate binding site [chemical binding]; other site 412022002107 oxyanion hole (OAH) forming residues; other site 412022002108 trimer interface [polypeptide binding]; other site 412022002109 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412022002110 CoenzymeA binding site [chemical binding]; other site 412022002111 subunit interaction site [polypeptide binding]; other site 412022002112 PHB binding site; other site 412022002113 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 412022002114 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 412022002115 active site 412022002116 AMP binding site [chemical binding]; other site 412022002117 homodimer interface [polypeptide binding]; other site 412022002118 acyl-activating enzyme (AAE) consensus motif; other site 412022002119 CoA binding site [chemical binding]; other site 412022002120 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 412022002121 MltA specific insert domain; Region: MltA; smart00925 412022002122 3D domain; Region: 3D; pfam06725 412022002123 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 412022002124 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 412022002125 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 412022002126 substrate binding site [chemical binding]; other site 412022002127 hexamer interface [polypeptide binding]; other site 412022002128 metal binding site [ion binding]; metal-binding site 412022002129 phosphoglycolate phosphatase; Provisional; Region: PRK13222 412022002130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022002131 motif II; other site 412022002132 anthranilate synthase component I; Provisional; Region: PRK13565 412022002133 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412022002134 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 412022002135 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 412022002136 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 412022002137 glutamine binding [chemical binding]; other site 412022002138 catalytic triad [active] 412022002139 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 412022002140 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412022002141 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412022002142 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 412022002143 active site 412022002144 ribulose/triose binding site [chemical binding]; other site 412022002145 phosphate binding site [ion binding]; other site 412022002146 substrate (anthranilate) binding pocket [chemical binding]; other site 412022002147 product (indole) binding pocket [chemical binding]; other site 412022002148 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 412022002149 putative active site [active] 412022002150 putative metal binding residues [ion binding]; other site 412022002151 signature motif; other site 412022002152 putative triphosphate binding site [ion binding]; other site 412022002153 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 412022002154 ligand binding site [chemical binding]; other site 412022002155 active site 412022002156 UGI interface [polypeptide binding]; other site 412022002157 catalytic site [active] 412022002158 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 412022002159 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412022002160 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 412022002161 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 412022002162 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022002163 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 412022002164 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 412022002165 dimerization domain [polypeptide binding]; other site 412022002166 dimer interface [polypeptide binding]; other site 412022002167 catalytic residues [active] 412022002168 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 412022002169 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 412022002170 GTP-binding protein YchF; Reviewed; Region: PRK09601 412022002171 YchF GTPase; Region: YchF; cd01900 412022002172 G1 box; other site 412022002173 GTP/Mg2+ binding site [chemical binding]; other site 412022002174 Switch I region; other site 412022002175 G2 box; other site 412022002176 Switch II region; other site 412022002177 G3 box; other site 412022002178 G4 box; other site 412022002179 G5 box; other site 412022002180 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 412022002181 NADH dehydrogenase subunit B; Validated; Region: PRK06411 412022002182 Helix-turn-helix domain; Region: HTH_18; pfam12833 412022002183 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 412022002184 Protein of unknown function (DUF419); Region: DUF419; cl15265 412022002185 Protein of unknown function (DUF419); Region: DUF419; cl15265 412022002186 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412022002187 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 412022002188 putative active site [active] 412022002189 catalytic site [active] 412022002190 putative metal binding site [ion binding]; other site 412022002191 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 412022002192 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 412022002193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022002194 Walker A/P-loop; other site 412022002195 ATP binding site [chemical binding]; other site 412022002196 Q-loop/lid; other site 412022002197 ABC transporter signature motif; other site 412022002198 Walker B; other site 412022002199 D-loop; other site 412022002200 H-loop/switch region; other site 412022002201 ABC transporter; Region: ABC_tran_2; pfam12848 412022002202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022002203 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 412022002204 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 412022002205 Isochorismatase family; Region: Isochorismatase; pfam00857 412022002206 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 412022002207 catalytic triad [active] 412022002208 conserved cis-peptide bond; other site 412022002209 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 412022002210 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 412022002211 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 412022002212 active site 412022002213 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 412022002214 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 412022002215 tRNA; other site 412022002216 putative tRNA binding site [nucleotide binding]; other site 412022002217 putative NADP binding site [chemical binding]; other site 412022002218 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 412022002219 peptide chain release factor 1; Validated; Region: prfA; PRK00591 412022002220 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412022002221 RF-1 domain; Region: RF-1; pfam00472 412022002222 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 412022002223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022002224 S-adenosylmethionine binding site [chemical binding]; other site 412022002225 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 412022002226 putative GSH binding site [chemical binding]; other site 412022002227 catalytic residues [active] 412022002228 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 412022002229 Flavoprotein; Region: Flavoprotein; pfam02441 412022002230 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 412022002231 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 412022002232 putative active site [active] 412022002233 metal binding site [ion binding]; metal-binding site 412022002234 amino acid transporter; Region: 2A0306; TIGR00909 412022002235 HTH-like domain; Region: HTH_21; pfam13276 412022002236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022002237 Integrase core domain; Region: rve; pfam00665 412022002238 Integrase core domain; Region: rve_3; pfam13683 412022002239 Transposase; Region: HTH_Tnp_1; pfam01527 412022002240 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022002241 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 412022002242 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 412022002243 active site 412022002244 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 412022002245 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412022002246 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022002247 Uncharacterized conserved protein [Function unknown]; Region: COG3246 412022002248 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 412022002249 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 412022002250 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022002251 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 412022002252 conserved cys residue [active] 412022002253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022002254 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412022002255 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412022002256 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412022002257 Zn binding site [ion binding]; other site 412022002258 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 412022002259 Peptidase family M28; Region: Peptidase_M28; pfam04389 412022002260 active site 412022002261 metal binding site [ion binding]; metal-binding site 412022002262 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022002263 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022002264 trimer interface [polypeptide binding]; other site 412022002265 eyelet of channel; other site 412022002266 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 412022002267 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 412022002268 choline-sulfatase; Region: chol_sulfatase; TIGR03417 412022002269 Sulfatase; Region: Sulfatase; cl17466 412022002270 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 412022002271 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 412022002272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002273 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 412022002274 substrate binding pocket [chemical binding]; other site 412022002275 dimerization interface [polypeptide binding]; other site 412022002276 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 412022002277 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 412022002278 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 412022002279 putative active site [active] 412022002280 putative substrate binding site [chemical binding]; other site 412022002281 putative cosubstrate binding site; other site 412022002282 catalytic site [active] 412022002283 Amino acid permease; Region: AA_permease_2; pfam13520 412022002284 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 412022002285 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 412022002286 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 412022002287 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 412022002288 FAD binding pocket [chemical binding]; other site 412022002289 FAD binding motif [chemical binding]; other site 412022002290 phosphate binding motif [ion binding]; other site 412022002291 beta-alpha-beta structure motif; other site 412022002292 NAD binding pocket [chemical binding]; other site 412022002293 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 412022002294 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022002295 catalytic loop [active] 412022002296 iron binding site [ion binding]; other site 412022002297 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 412022002298 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 412022002299 [2Fe-2S] cluster binding site [ion binding]; other site 412022002300 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 412022002301 putative alpha subunit interface [polypeptide binding]; other site 412022002302 putative active site [active] 412022002303 putative substrate binding site [chemical binding]; other site 412022002304 Fe binding site [ion binding]; other site 412022002305 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 412022002306 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 412022002307 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 412022002308 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 412022002309 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412022002310 Cysteine-rich domain; Region: CCG; pfam02754 412022002311 Cysteine-rich domain; Region: CCG; pfam02754 412022002312 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 412022002313 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 412022002314 putative active site [active] 412022002315 putative FMN binding site [chemical binding]; other site 412022002316 putative substrate binding site [chemical binding]; other site 412022002317 putative catalytic residue [active] 412022002318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412022002319 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 412022002320 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 412022002321 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 412022002322 active site 412022002323 dimer interface [polypeptide binding]; other site 412022002324 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 412022002325 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 412022002326 dimer interface [polypeptide binding]; other site 412022002327 active site 412022002328 glycine-pyridoxal phosphate binding site [chemical binding]; other site 412022002329 folate binding site [chemical binding]; other site 412022002330 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022002331 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 412022002332 conserved cys residue [active] 412022002333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022002334 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 412022002335 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 412022002336 NAD binding site [chemical binding]; other site 412022002337 catalytic Zn binding site [ion binding]; other site 412022002338 structural Zn binding site [ion binding]; other site 412022002339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412022002340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412022002341 DNA binding site [nucleotide binding] 412022002342 domain linker motif; other site 412022002343 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 412022002344 ligand binding site [chemical binding]; other site 412022002345 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 412022002346 active site 412022002347 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 412022002348 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 412022002349 substrate binding [chemical binding]; other site 412022002350 active site 412022002351 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 412022002352 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 412022002353 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022002354 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022002355 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022002356 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 412022002357 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 412022002358 Ligand binding site; other site 412022002359 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022002360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022002361 putative substrate translocation pore; other site 412022002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022002363 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 412022002364 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 412022002365 active site 412022002366 TDP-binding site; other site 412022002367 acceptor substrate-binding pocket; other site 412022002368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022002369 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 412022002370 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 412022002371 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 412022002372 hypothetical protein; Provisional; Region: PRK14693 412022002373 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 412022002374 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022002375 ligand binding site [chemical binding]; other site 412022002376 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 412022002377 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 412022002378 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 412022002379 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 412022002380 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 412022002381 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 412022002382 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022002383 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 412022002384 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002385 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 412022002386 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022002387 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022002388 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 412022002389 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022002390 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022002391 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 412022002392 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022002393 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022002394 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 412022002395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002396 Walker A motif; other site 412022002397 ATP binding site [chemical binding]; other site 412022002398 Walker B motif; other site 412022002399 arginine finger; other site 412022002400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412022002401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002402 Walker A motif; other site 412022002403 ATP binding site [chemical binding]; other site 412022002404 Walker B motif; other site 412022002405 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412022002406 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 412022002407 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 412022002408 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 412022002409 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 412022002410 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 412022002411 Protein of unknown function (DUF796); Region: DUF796; pfam05638 412022002412 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 412022002413 Protein of unknown function (DUF877); Region: DUF877; pfam05943 412022002414 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 412022002415 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 412022002416 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 412022002417 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 412022002418 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 412022002419 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 412022002420 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 412022002421 putative membrane protein; Region: HpnL; TIGR03476 412022002422 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 412022002423 active site 412022002424 metal-binding site 412022002425 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 412022002426 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 412022002427 tetramer interface [polypeptide binding]; other site 412022002428 active site 412022002429 Mg2+/Mn2+ binding site [ion binding]; other site 412022002430 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 412022002431 active site 412022002432 metal-binding site 412022002433 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 412022002434 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022002435 dimer interface [polypeptide binding]; other site 412022002436 PYR/PP interface [polypeptide binding]; other site 412022002437 TPP binding site [chemical binding]; other site 412022002438 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 412022002439 TPP-binding site [chemical binding]; other site 412022002440 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022002441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022002442 catalytic residue [active] 412022002443 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 412022002444 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 412022002445 conserved cys residue [active] 412022002446 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022002447 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 412022002448 conserved cys residue [active] 412022002449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022002450 Predicted membrane protein [Function unknown]; Region: COG1289 412022002451 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 412022002452 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 412022002453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022002454 putative substrate translocation pore; other site 412022002455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022002456 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022002457 DNA-binding site [nucleotide binding]; DNA binding site 412022002458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022002459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022002460 homodimer interface [polypeptide binding]; other site 412022002461 catalytic residue [active] 412022002462 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 412022002463 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 412022002464 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 412022002465 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 412022002466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 412022002467 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 412022002468 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 412022002469 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 412022002470 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 412022002471 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 412022002472 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 412022002473 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 412022002474 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 412022002475 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 412022002476 Transglutaminase/protease-like homologues; Region: TGc; smart00460 412022002477 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 412022002478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 412022002479 Uncharacterized conserved protein [Function unknown]; Region: COG2308 412022002480 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 412022002481 putative FMN binding site [chemical binding]; other site 412022002482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 412022002483 Chitin binding domain; Region: Chitin_bind_3; pfam03067 412022002484 peroxiredoxin; Region: AhpC; TIGR03137 412022002485 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 412022002486 dimer interface [polypeptide binding]; other site 412022002487 decamer (pentamer of dimers) interface [polypeptide binding]; other site 412022002488 catalytic triad [active] 412022002489 peroxidatic and resolving cysteines [active] 412022002490 Transposase; Region: HTH_Tnp_1; pfam01527 412022002491 HTH-like domain; Region: HTH_21; pfam13276 412022002492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022002493 Integrase core domain; Region: rve; pfam00665 412022002494 Integrase core domain; Region: rve_3; pfam13683 412022002495 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 412022002496 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 412022002497 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 412022002498 acetyl-CoA synthetase; Provisional; Region: PRK00174 412022002499 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 412022002500 active site 412022002501 CoA binding site [chemical binding]; other site 412022002502 acyl-activating enzyme (AAE) consensus motif; other site 412022002503 AMP binding site [chemical binding]; other site 412022002504 acetate binding site [chemical binding]; other site 412022002505 EamA-like transporter family; Region: EamA; pfam00892 412022002506 EamA-like transporter family; Region: EamA; pfam00892 412022002507 hypothetical protein; Provisional; Region: PRK05208 412022002508 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 412022002509 Fumarase C-terminus; Region: Fumerase_C; pfam05683 412022002510 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 412022002511 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 412022002512 heme binding site [chemical binding]; other site 412022002513 ferroxidase pore; other site 412022002514 ferroxidase diiron center [ion binding]; other site 412022002515 glutamate racemase; Provisional; Region: PRK00865 412022002516 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 412022002517 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 412022002518 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 412022002519 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 412022002520 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 412022002521 Transposase domain (DUF772); Region: DUF772; pfam05598 412022002522 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022002523 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022002524 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 412022002525 DAK2 domain; Region: Dak2; pfam02734 412022002526 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 412022002527 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 412022002528 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 412022002529 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 412022002530 putative NAD(P) binding site [chemical binding]; other site 412022002531 catalytic Zn binding site [ion binding]; other site 412022002532 structural Zn binding site [ion binding]; other site 412022002533 short chain dehydrogenase; Provisional; Region: PRK06841 412022002534 classical (c) SDRs; Region: SDR_c; cd05233 412022002535 NAD(P) binding site [chemical binding]; other site 412022002536 active site 412022002537 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 412022002538 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 412022002539 putative ligand binding site [chemical binding]; other site 412022002540 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022002541 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022002542 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 412022002543 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412022002544 Walker A/P-loop; other site 412022002545 ATP binding site [chemical binding]; other site 412022002546 Q-loop/lid; other site 412022002547 ABC transporter signature motif; other site 412022002548 Walker B; other site 412022002549 D-loop; other site 412022002550 H-loop/switch region; other site 412022002551 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412022002552 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 412022002553 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 412022002554 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 412022002555 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 412022002556 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022002557 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022002558 trimer interface [polypeptide binding]; other site 412022002559 eyelet of channel; other site 412022002560 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 412022002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022002562 dimer interface [polypeptide binding]; other site 412022002563 conserved gate region; other site 412022002564 putative PBP binding loops; other site 412022002565 ABC-ATPase subunit interface; other site 412022002566 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 412022002567 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412022002568 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412022002569 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 412022002570 Walker A/P-loop; other site 412022002571 ATP binding site [chemical binding]; other site 412022002572 Q-loop/lid; other site 412022002573 ABC transporter signature motif; other site 412022002574 Walker B; other site 412022002575 D-loop; other site 412022002576 H-loop/switch region; other site 412022002577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022002578 dimer interface [polypeptide binding]; other site 412022002579 conserved gate region; other site 412022002580 putative PBP binding loops; other site 412022002581 ABC-ATPase subunit interface; other site 412022002582 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022002583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022002585 dimerization interface [polypeptide binding]; other site 412022002586 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 412022002587 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022002588 N-terminal plug; other site 412022002589 ligand-binding site [chemical binding]; other site 412022002590 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 412022002591 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 412022002592 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 412022002593 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412022002594 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 412022002595 intersubunit interface [polypeptide binding]; other site 412022002596 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412022002597 putative PBP binding regions; other site 412022002598 ABC-ATPase subunit interface; other site 412022002599 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 412022002600 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412022002601 Walker A/P-loop; other site 412022002602 ATP binding site [chemical binding]; other site 412022002603 Q-loop/lid; other site 412022002604 ABC transporter signature motif; other site 412022002605 Walker B; other site 412022002606 D-loop; other site 412022002607 H-loop/switch region; other site 412022002608 Predicted membrane protein [Function unknown]; Region: COG2860 412022002609 UPF0126 domain; Region: UPF0126; pfam03458 412022002610 UPF0126 domain; Region: UPF0126; pfam03458 412022002611 Transglycosylase; Region: Transgly; pfam00912 412022002612 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412022002613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412022002614 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 412022002615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002616 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 412022002617 putative dimerization interface [polypeptide binding]; other site 412022002618 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 412022002619 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 412022002620 tetramer interface [polypeptide binding]; other site 412022002621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022002622 catalytic residue [active] 412022002623 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 412022002624 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 412022002625 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 412022002626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022002627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022002628 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 412022002629 active site lid residues [active] 412022002630 substrate binding pocket [chemical binding]; other site 412022002631 catalytic residues [active] 412022002632 substrate-Mg2+ binding site; other site 412022002633 aspartate-rich region 1; other site 412022002634 aspartate-rich region 2; other site 412022002635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022002636 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 412022002637 active site 412022002638 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 412022002639 Sulfatase; Region: Sulfatase; cl17466 412022002640 Sulfatase; Region: Sulfatase; cl17466 412022002641 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 412022002642 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 412022002643 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 412022002644 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 412022002645 Uncharacterized conserved protein [Function unknown]; Region: COG5361 412022002646 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 412022002647 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 412022002648 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 412022002649 Heavy-metal-associated domain; Region: HMA; pfam00403 412022002650 metal-binding site [ion binding] 412022002651 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412022002652 metal-binding site [ion binding] 412022002653 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412022002654 metal-binding site [ion binding] 412022002655 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412022002656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412022002657 metal-binding site [ion binding] 412022002658 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412022002659 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 412022002660 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412022002661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022002662 Coenzyme A binding pocket [chemical binding]; other site 412022002663 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 412022002664 MgtC family; Region: MgtC; pfam02308 412022002665 dimerization interface [polypeptide binding]; other site 412022002666 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 412022002667 putative active cleft [active] 412022002668 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 412022002669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002670 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 412022002671 dimerization interface [polypeptide binding]; other site 412022002672 substrate binding pocket [chemical binding]; other site 412022002673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022002674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022002675 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 412022002676 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 412022002677 dimer interface [polypeptide binding]; other site 412022002678 ligand binding site [chemical binding]; other site 412022002679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022002680 dimer interface [polypeptide binding]; other site 412022002681 putative CheW interface [polypeptide binding]; other site 412022002682 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 412022002683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022002684 FeS/SAM binding site; other site 412022002685 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 412022002686 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 412022002687 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 412022002688 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 412022002689 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 412022002690 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 412022002691 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412022002692 CoenzymeA binding site [chemical binding]; other site 412022002693 subunit interaction site [polypeptide binding]; other site 412022002694 PHB binding site; other site 412022002695 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 412022002696 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 412022002697 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 412022002698 substrate binding site [chemical binding]; other site 412022002699 ligand binding site [chemical binding]; other site 412022002700 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 412022002701 substrate binding site [chemical binding]; other site 412022002702 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 412022002703 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 412022002704 dimer interface [polypeptide binding]; other site 412022002705 active site 412022002706 citrylCoA binding site [chemical binding]; other site 412022002707 oxalacetate/citrate binding site [chemical binding]; other site 412022002708 coenzyme A binding site [chemical binding]; other site 412022002709 catalytic triad [active] 412022002710 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 412022002711 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 412022002712 tetramer interface [polypeptide binding]; other site 412022002713 active site 412022002714 Mg2+/Mn2+ binding site [ion binding]; other site 412022002715 Propionate catabolism activator; Region: PrpR_N; pfam06506 412022002716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022002717 putative active site [active] 412022002718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002719 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412022002720 Walker A motif; other site 412022002721 ATP binding site [chemical binding]; other site 412022002722 Walker B motif; other site 412022002723 arginine finger; other site 412022002724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022002725 dimerization interface [polypeptide binding]; other site 412022002726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022002727 dimer interface [polypeptide binding]; other site 412022002728 putative CheW interface [polypeptide binding]; other site 412022002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022002730 S-adenosylmethionine binding site [chemical binding]; other site 412022002731 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 412022002732 TAP-like protein; Region: Abhydrolase_4; pfam08386 412022002733 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 412022002734 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 412022002735 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 412022002736 active site 412022002737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022002738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002739 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 412022002740 putative substrate binding pocket [chemical binding]; other site 412022002741 dimerization interface [polypeptide binding]; other site 412022002742 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 412022002743 putative active site [active] 412022002744 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412022002745 carboxyltransferase (CT) interaction site; other site 412022002746 biotinylation site [posttranslational modification]; other site 412022002747 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 412022002748 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412022002749 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412022002750 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412022002751 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 412022002752 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 412022002753 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 412022002754 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 412022002755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022002756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 412022002757 dimer interface [polypeptide binding]; other site 412022002758 putative metal binding site [ion binding]; other site 412022002759 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 412022002760 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412022002761 homodimer interface [polypeptide binding]; other site 412022002762 substrate-cofactor binding pocket; other site 412022002763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022002764 catalytic residue [active] 412022002765 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 412022002766 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412022002767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022002768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002769 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 412022002770 putative substrate binding pocket [chemical binding]; other site 412022002771 putative dimerization interface [polypeptide binding]; other site 412022002772 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 412022002773 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 412022002774 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 412022002775 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412022002776 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 412022002777 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002778 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002779 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 412022002780 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002781 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 412022002782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002784 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412022002785 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 412022002786 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022002787 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022002788 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 412022002789 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 412022002790 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 412022002791 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 412022002792 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 412022002793 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 412022002794 ImpE protein; Region: ImpE; pfam07024 412022002795 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 412022002796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002797 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412022002798 Walker A motif; other site 412022002799 ATP binding site [chemical binding]; other site 412022002800 Walker B motif; other site 412022002801 arginine finger; other site 412022002802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002803 Walker A motif; other site 412022002804 ATP binding site [chemical binding]; other site 412022002805 Walker B motif; other site 412022002806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412022002807 Protein of unknown function (DUF770); Region: DUF770; pfam05591 412022002808 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 412022002809 Protein of unknown function (DUF877); Region: DUF877; pfam05943 412022002810 Protein of unknown function (DUF796); Region: DUF796; pfam05638 412022002811 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 412022002812 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 412022002813 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 412022002814 hypothetical protein; Provisional; Region: PRK08126 412022002815 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 412022002816 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022002817 ligand binding site [chemical binding]; other site 412022002818 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 412022002819 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 412022002820 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 412022002821 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 412022002822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022002823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002824 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022002825 putative effector binding pocket; other site 412022002826 dimerization interface [polypeptide binding]; other site 412022002827 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 412022002828 active site 412022002829 metal binding site [ion binding]; metal-binding site 412022002830 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412022002831 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 412022002832 NADP binding site [chemical binding]; other site 412022002833 dimer interface [polypeptide binding]; other site 412022002834 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412022002835 active site 412022002836 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 412022002837 dimer interface [polypeptide binding]; other site 412022002838 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412022002839 Ligand Binding Site [chemical binding]; other site 412022002840 Molecular Tunnel; other site 412022002841 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 412022002842 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 412022002843 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 412022002844 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022002845 substrate binding pocket [chemical binding]; other site 412022002846 active site 412022002847 iron coordination sites [ion binding]; other site 412022002848 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 412022002849 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 412022002850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022002851 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022002852 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 412022002853 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 412022002854 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 412022002855 SnoaL-like domain; Region: SnoaL_2; pfam12680 412022002856 short chain dehydrogenase; Provisional; Region: PRK07023 412022002857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022002858 NAD(P) binding site [chemical binding]; other site 412022002859 active site 412022002860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022002861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022002863 dimerization interface [polypeptide binding]; other site 412022002864 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 412022002865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412022002866 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 412022002867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022002868 substrate binding pocket [chemical binding]; other site 412022002869 membrane-bound complex binding site; other site 412022002870 hinge residues; other site 412022002871 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 412022002872 putative di-iron ligands [ion binding]; other site 412022002873 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 412022002874 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 412022002875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022002876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022002877 dimerization interface [polypeptide binding]; other site 412022002878 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412022002879 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 412022002880 metal binding site [ion binding]; metal-binding site 412022002881 putative dimer interface [polypeptide binding]; other site 412022002882 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022002883 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022002884 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022002885 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 412022002886 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412022002887 ATP binding site [chemical binding]; other site 412022002888 Mg++ binding site [ion binding]; other site 412022002889 motif III; other site 412022002890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022002891 nucleotide binding region [chemical binding]; other site 412022002892 ATP-binding site [chemical binding]; other site 412022002893 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 412022002894 putative RNA binding site [nucleotide binding]; other site 412022002895 Transposase; Region: HTH_Tnp_1; pfam01527 412022002896 HTH-like domain; Region: HTH_21; pfam13276 412022002897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022002898 Integrase core domain; Region: rve; pfam00665 412022002899 Integrase core domain; Region: rve_3; pfam13683 412022002900 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022002901 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022002902 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022002903 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 412022002904 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022002905 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 412022002906 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022002907 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022002908 trimer interface [polypeptide binding]; other site 412022002909 eyelet of channel; other site 412022002910 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 412022002911 2-methylcitrate dehydratase; Region: prpD; TIGR02330 412022002912 OpgC protein; Region: OpgC_C; pfam10129 412022002913 Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Region: DBF4; COG5067 412022002914 Predicted permeases [General function prediction only]; Region: RarD; COG2962 412022002915 acylphosphatase; Provisional; Region: PRK14424 412022002916 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 412022002917 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 412022002918 putative NADP binding site [chemical binding]; other site 412022002919 putative substrate binding site [chemical binding]; other site 412022002920 active site 412022002921 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 412022002922 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 412022002923 active site 412022002924 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 412022002925 LytB protein; Region: LYTB; pfam02401 412022002926 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 412022002927 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022002928 FeS/SAM binding site; other site 412022002929 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 412022002930 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 412022002931 aminotransferase; Validated; Region: PRK07046 412022002932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022002933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022002934 catalytic residue [active] 412022002935 Transposase domain (DUF772); Region: DUF772; pfam05598 412022002936 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022002937 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022002938 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 412022002939 short chain dehydrogenase; Provisional; Region: PRK06701 412022002940 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 412022002941 NAD binding site [chemical binding]; other site 412022002942 metal binding site [ion binding]; metal-binding site 412022002943 active site 412022002944 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 412022002945 short chain dehydrogenase; Provisional; Region: PRK07109 412022002946 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 412022002947 putative NAD(P) binding site [chemical binding]; other site 412022002948 active site 412022002949 BON domain; Region: BON; pfam04972 412022002950 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 412022002951 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 412022002952 putative ADP-binding pocket [chemical binding]; other site 412022002953 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 412022002954 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022002955 NAD binding site [chemical binding]; other site 412022002956 putative substrate binding site 2 [chemical binding]; other site 412022002957 putative substrate binding site 1 [chemical binding]; other site 412022002958 active site 412022002959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022002960 PAS domain; Region: PAS_9; pfam13426 412022002961 putative active site [active] 412022002962 heme pocket [chemical binding]; other site 412022002963 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412022002964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022002965 putative active site [active] 412022002966 heme pocket [chemical binding]; other site 412022002967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022002968 dimer interface [polypeptide binding]; other site 412022002969 phosphorylation site [posttranslational modification] 412022002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022002971 ATP binding site [chemical binding]; other site 412022002972 Mg2+ binding site [ion binding]; other site 412022002973 G-X-G motif; other site 412022002974 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 412022002975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022002976 active site 412022002977 phosphorylation site [posttranslational modification] 412022002978 intermolecular recognition site; other site 412022002979 dimerization interface [polypeptide binding]; other site 412022002980 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 412022002981 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 412022002982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412022002983 active site 412022002984 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022002985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022002986 active site 412022002987 phosphorylation site [posttranslational modification] 412022002988 intermolecular recognition site; other site 412022002989 dimerization interface [polypeptide binding]; other site 412022002990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002991 Walker A motif; other site 412022002992 ATP binding site [chemical binding]; other site 412022002993 Walker B motif; other site 412022002994 arginine finger; other site 412022002995 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022002996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022002997 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 412022002998 Walker A motif; other site 412022002999 ATP binding site [chemical binding]; other site 412022003000 Walker B motif; other site 412022003001 arginine finger; other site 412022003002 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 412022003003 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022003004 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022003005 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022003006 putative active site [active] 412022003007 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 412022003008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412022003009 active site 412022003010 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 412022003011 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 412022003012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022003013 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022003014 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022003015 putative active site [active] 412022003016 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 412022003017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022003018 active site 412022003019 motif I; other site 412022003020 motif II; other site 412022003021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 412022003022 classical (c) SDRs; Region: SDR_c; cd05233 412022003023 NAD(P) binding site [chemical binding]; other site 412022003024 active site 412022003025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412022003026 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 412022003027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022003028 Walker A/P-loop; other site 412022003029 ATP binding site [chemical binding]; other site 412022003030 Q-loop/lid; other site 412022003031 ABC transporter signature motif; other site 412022003032 Walker B; other site 412022003033 D-loop; other site 412022003034 H-loop/switch region; other site 412022003035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 412022003036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003037 Response regulator receiver domain; Region: Response_reg; pfam00072 412022003038 active site 412022003039 phosphorylation site [posttranslational modification] 412022003040 intermolecular recognition site; other site 412022003041 dimerization interface [polypeptide binding]; other site 412022003042 BON domain; Region: BON; pfam04972 412022003043 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 412022003044 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 412022003045 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575 412022003046 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 412022003047 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 412022003048 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412022003049 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 412022003050 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 412022003051 active site 412022003052 non-prolyl cis peptide bond; other site 412022003053 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 412022003054 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 412022003055 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 412022003056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022003057 putative substrate translocation pore; other site 412022003058 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 412022003059 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022003060 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 412022003061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022003062 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412022003063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412022003064 E3 interaction surface; other site 412022003065 lipoyl attachment site [posttranslational modification]; other site 412022003066 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 412022003067 e3 binding domain; Region: E3_binding; pfam02817 412022003068 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412022003069 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 412022003070 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 412022003071 alpha subunit interface [polypeptide binding]; other site 412022003072 TPP binding site [chemical binding]; other site 412022003073 heterodimer interface [polypeptide binding]; other site 412022003074 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412022003075 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 412022003076 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 412022003077 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 412022003078 tetramer interface [polypeptide binding]; other site 412022003079 TPP-binding site [chemical binding]; other site 412022003080 heterodimer interface [polypeptide binding]; other site 412022003081 phosphorylation loop region [posttranslational modification] 412022003082 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 412022003083 putative hydrophobic ligand binding site [chemical binding]; other site 412022003084 protein interface [polypeptide binding]; other site 412022003085 gate; other site 412022003086 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 412022003087 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 412022003088 hydrophobic ligand binding site; other site 412022003089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003091 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 412022003092 substrate binding pocket [chemical binding]; other site 412022003093 dimerization interface [polypeptide binding]; other site 412022003094 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 412022003095 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 412022003096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 412022003097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022003098 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 412022003099 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 412022003100 nucleophile elbow; other site 412022003101 Patatin phospholipase; Region: DUF3734; pfam12536 412022003102 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 412022003103 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 412022003104 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 412022003105 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 412022003106 active site 412022003107 dimer interface [polypeptide binding]; other site 412022003108 effector binding site; other site 412022003109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 412022003110 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 412022003111 AAA domain; Region: AAA_33; pfam13671 412022003112 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 412022003113 FMN binding site [chemical binding]; other site 412022003114 dimer interface [polypeptide binding]; other site 412022003115 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 412022003116 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 412022003117 Sulfate transporter family; Region: Sulfate_transp; pfam00916 412022003118 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 412022003119 FOG: CBS domain [General function prediction only]; Region: COG0517 412022003120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 412022003121 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 412022003122 putative FMN binding site [chemical binding]; other site 412022003123 NADPH bind site [chemical binding]; other site 412022003124 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412022003125 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 412022003126 putative dimer interface [polypeptide binding]; other site 412022003127 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022003128 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022003129 trimer interface [polypeptide binding]; other site 412022003130 eyelet of channel; other site 412022003131 putative acyl-CoA synthetase; Provisional; Region: PRK06018 412022003132 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022003133 acyl-activating enzyme (AAE) consensus motif; other site 412022003134 AMP binding site [chemical binding]; other site 412022003135 active site 412022003136 CoA binding site [chemical binding]; other site 412022003137 AAA ATPase domain; Region: AAA_16; pfam13191 412022003138 AAA domain; Region: AAA_22; pfam13401 412022003139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022003140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022003141 DNA binding residues [nucleotide binding] 412022003142 dimerization interface [polypeptide binding]; other site 412022003143 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 412022003144 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 412022003145 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 412022003146 NADP binding site [chemical binding]; other site 412022003147 dimer interface [polypeptide binding]; other site 412022003148 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022003149 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 412022003150 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 412022003151 benzoate transport; Region: 2A0115; TIGR00895 412022003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022003153 putative substrate translocation pore; other site 412022003154 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 412022003155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022003156 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 412022003157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022003158 molybdopterin cofactor binding site; other site 412022003159 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 412022003160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022003161 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 412022003162 putative molybdopterin cofactor binding site; other site 412022003163 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 412022003164 4Fe-4S binding domain; Region: Fer4; pfam00037 412022003165 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 412022003166 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 412022003167 putative active site [active] 412022003168 putative metal binding site [ion binding]; other site 412022003169 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 412022003170 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 412022003171 Transglycosylase; Region: Transgly; pfam00912 412022003172 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412022003173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412022003174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412022003175 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022003176 catalytic residues [active] 412022003177 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022003178 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022003179 trimer interface [polypeptide binding]; other site 412022003180 eyelet of channel; other site 412022003181 amidase; Provisional; Region: PRK08137 412022003182 Amidase; Region: Amidase; cl11426 412022003183 putative acetyltransferase YhhY; Provisional; Region: PRK10140 412022003184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022003185 Coenzyme A binding pocket [chemical binding]; other site 412022003186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022003187 putative acetyltransferase YhhY; Provisional; Region: PRK10140 412022003188 Coenzyme A binding pocket [chemical binding]; other site 412022003189 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 412022003190 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 412022003191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022003192 D-loop; other site 412022003193 H-loop/switch region; other site 412022003194 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022003195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 412022003196 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 412022003197 Histidine kinase; Region: HisKA_3; pfam07730 412022003198 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 412022003199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022003200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003201 active site 412022003202 phosphorylation site [posttranslational modification] 412022003203 intermolecular recognition site; other site 412022003204 dimerization interface [polypeptide binding]; other site 412022003205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022003206 DNA binding residues [nucleotide binding] 412022003207 dimerization interface [polypeptide binding]; other site 412022003208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022003209 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022003210 Transposase domain (DUF772); Region: DUF772; pfam05598 412022003211 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022003212 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022003213 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 412022003214 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 412022003215 PAS domain; Region: PAS_9; pfam13426 412022003216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022003217 putative active site [active] 412022003218 heme pocket [chemical binding]; other site 412022003219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022003220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022003221 metal binding site [ion binding]; metal-binding site 412022003222 active site 412022003223 I-site; other site 412022003224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412022003225 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 412022003226 Lipase (class 2); Region: Lipase_2; pfam01674 412022003227 PGAP1-like protein; Region: PGAP1; pfam07819 412022003228 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 412022003229 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 412022003230 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 412022003231 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 412022003232 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 412022003233 FtsX-like permease family; Region: FtsX; pfam02687 412022003234 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412022003235 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412022003236 Walker A/P-loop; other site 412022003237 ATP binding site [chemical binding]; other site 412022003238 Q-loop/lid; other site 412022003239 ABC transporter signature motif; other site 412022003240 Walker B; other site 412022003241 D-loop; other site 412022003242 H-loop/switch region; other site 412022003243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022003244 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 412022003245 Cytochrome P450; Region: p450; cl12078 412022003246 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 412022003247 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 412022003248 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 412022003249 putative NADP binding site [chemical binding]; other site 412022003250 active site 412022003251 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 412022003252 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 412022003253 putative NAD(P) binding site [chemical binding]; other site 412022003254 active site 412022003255 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 412022003256 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 412022003257 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022003258 active site 412022003259 active site 412022003260 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 412022003261 active site 412022003262 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 412022003263 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 412022003264 putative NADP binding site [chemical binding]; other site 412022003265 active site 412022003266 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412022003267 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 412022003268 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 412022003269 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 412022003270 VacJ like lipoprotein; Region: VacJ; cl01073 412022003271 hypothetical protein; Provisional; Region: PRK07483 412022003272 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022003273 inhibitor-cofactor binding pocket; inhibition site 412022003274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022003275 catalytic residue [active] 412022003276 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 412022003277 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 412022003278 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022003279 Walker A/P-loop; other site 412022003280 ATP binding site [chemical binding]; other site 412022003281 Q-loop/lid; other site 412022003282 ABC transporter signature motif; other site 412022003283 Walker B; other site 412022003284 D-loop; other site 412022003285 H-loop/switch region; other site 412022003286 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022003287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022003288 dimer interface [polypeptide binding]; other site 412022003289 conserved gate region; other site 412022003290 putative PBP binding loops; other site 412022003291 ABC-ATPase subunit interface; other site 412022003292 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022003293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022003294 substrate binding pocket [chemical binding]; other site 412022003295 membrane-bound complex binding site; other site 412022003296 hinge residues; other site 412022003297 hypothetical protein; Provisional; Region: PRK07077 412022003298 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 412022003299 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 412022003300 Active site cavity [active] 412022003301 catalytic acid [active] 412022003302 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 412022003303 active site lid residues [active] 412022003304 substrate binding pocket [chemical binding]; other site 412022003305 catalytic residues [active] 412022003306 substrate-Mg2+ binding site; other site 412022003307 aspartate-rich region 1; other site 412022003308 aspartate-rich region 2; other site 412022003309 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 412022003310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022003311 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022003312 PAS fold; Region: PAS_4; pfam08448 412022003313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022003314 putative active site [active] 412022003315 heme pocket [chemical binding]; other site 412022003316 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022003317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022003318 metal binding site [ion binding]; metal-binding site 412022003319 active site 412022003320 I-site; other site 412022003321 Response regulator receiver domain; Region: Response_reg; pfam00072 412022003322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003323 active site 412022003324 phosphorylation site [posttranslational modification] 412022003325 intermolecular recognition site; other site 412022003326 dimerization interface [polypeptide binding]; other site 412022003327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022003328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022003329 dimer interface [polypeptide binding]; other site 412022003330 phosphorylation site [posttranslational modification] 412022003331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022003332 ATP binding site [chemical binding]; other site 412022003333 Mg2+ binding site [ion binding]; other site 412022003334 G-X-G motif; other site 412022003335 Response regulator receiver domain; Region: Response_reg; pfam00072 412022003336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003337 active site 412022003338 phosphorylation site [posttranslational modification] 412022003339 intermolecular recognition site; other site 412022003340 dimerization interface [polypeptide binding]; other site 412022003341 Predicted flavoprotein [General function prediction only]; Region: COG0431 412022003342 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412022003343 RNA polymerase sigma factor; Provisional; Region: PRK12545 412022003344 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 412022003345 DNA binding residues [nucleotide binding] 412022003346 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 412022003347 ArsC family; Region: ArsC; pfam03960 412022003348 catalytic residues [active] 412022003349 ParA-like protein; Provisional; Region: PHA02518 412022003350 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412022003351 P-loop; other site 412022003352 Magnesium ion binding site [ion binding]; other site 412022003353 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 412022003354 ParB-like nuclease domain; Region: ParB; smart00470 412022003355 Transposase domain (DUF772); Region: DUF772; pfam05598 412022003356 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022003357 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022003358 Initiator Replication protein; Region: Rep_3; pfam01051 412022003359 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 412022003360 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 412022003361 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 412022003362 active site 412022003363 Int/Topo IB signature motif; other site 412022003364 catalytic residues [active] 412022003365 DNA binding site [nucleotide binding] 412022003366 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 412022003367 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412022003368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022003369 non-specific DNA binding site [nucleotide binding]; other site 412022003370 salt bridge; other site 412022003371 sequence-specific DNA binding site [nucleotide binding]; other site 412022003372 Cupin domain; Region: Cupin_2; pfam07883 412022003373 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 412022003374 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 412022003375 substrate-cofactor binding pocket; other site 412022003376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022003377 catalytic residue [active] 412022003378 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 412022003379 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412022003380 NAD(P) binding site [chemical binding]; other site 412022003381 Uncharacterized conserved protein [Function unknown]; Region: COG2353 412022003382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022003383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022003384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 412022003385 SnoaL-like domain; Region: SnoaL_2; pfam12680 412022003386 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 412022003387 putative active site [active] 412022003388 Zn binding site [ion binding]; other site 412022003389 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 412022003390 tartrate dehydrogenase; Region: TTC; TIGR02089 412022003391 transcriptional activator TtdR; Provisional; Region: PRK09801 412022003392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003393 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 412022003394 putative effector binding pocket; other site 412022003395 putative dimerization interface [polypeptide binding]; other site 412022003396 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 412022003397 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412022003398 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 412022003399 putative C-terminal domain interface [polypeptide binding]; other site 412022003400 putative GSH binding site (G-site) [chemical binding]; other site 412022003401 putative dimer interface [polypeptide binding]; other site 412022003402 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 412022003403 putative N-terminal domain interface [polypeptide binding]; other site 412022003404 putative dimer interface [polypeptide binding]; other site 412022003405 putative substrate binding pocket (H-site) [chemical binding]; other site 412022003406 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 412022003407 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 412022003408 nucleophile elbow; other site 412022003409 Patatin phospholipase; Region: DUF3734; pfam12536 412022003410 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 412022003411 classical (c) SDRs; Region: SDR_c; cd05233 412022003412 NAD(P) binding site [chemical binding]; other site 412022003413 active site 412022003414 acetoacetate decarboxylase; Provisional; Region: PRK02265 412022003415 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 412022003416 active site 412022003417 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 412022003418 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 412022003419 FAD binding pocket [chemical binding]; other site 412022003420 FAD binding motif [chemical binding]; other site 412022003421 phosphate binding motif [ion binding]; other site 412022003422 NAD binding pocket [chemical binding]; other site 412022003423 Predicted transcriptional regulators [Transcription]; Region: COG1695 412022003424 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 412022003425 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 412022003426 Cytochrome P450; Region: p450; cl12078 412022003427 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 412022003428 Protein of unknown function (DUF692); Region: DUF692; cl01263 412022003429 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 412022003430 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 412022003431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022003432 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 412022003433 FeS/SAM binding site; other site 412022003434 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022003435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022003436 S-adenosylmethionine binding site [chemical binding]; other site 412022003437 Lysine efflux permease [General function prediction only]; Region: COG1279 412022003438 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 412022003439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022003441 dimerization interface [polypeptide binding]; other site 412022003442 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 412022003443 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412022003444 ligand binding site [chemical binding]; other site 412022003445 flexible hinge region; other site 412022003446 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 412022003447 putative switch regulator; other site 412022003448 non-specific DNA interactions [nucleotide binding]; other site 412022003449 DNA binding site [nucleotide binding] 412022003450 sequence specific DNA binding site [nucleotide binding]; other site 412022003451 putative cAMP binding site [chemical binding]; other site 412022003452 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022003453 Ligand Binding Site [chemical binding]; other site 412022003454 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 412022003455 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 412022003456 dimer interface [polypeptide binding]; other site 412022003457 NADP binding site [chemical binding]; other site 412022003458 catalytic residues [active] 412022003459 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 412022003460 HTH-like domain; Region: HTH_21; pfam13276 412022003461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022003462 Integrase core domain; Region: rve; pfam00665 412022003463 Integrase core domain; Region: rve_3; pfam13683 412022003464 Transposase; Region: HTH_Tnp_1; pfam01527 412022003465 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 412022003466 Strictosidine synthase; Region: Str_synth; pfam03088 412022003467 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 412022003468 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 412022003469 serine O-acetyltransferase; Region: cysE; TIGR01172 412022003470 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 412022003471 trimer interface [polypeptide binding]; other site 412022003472 active site 412022003473 substrate binding site [chemical binding]; other site 412022003474 CoA binding site [chemical binding]; other site 412022003475 short chain dehydrogenase; Provisional; Region: PRK09134 412022003476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022003477 NAD(P) binding site [chemical binding]; other site 412022003478 active site 412022003479 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 412022003480 GTP cyclohydrolase I; Provisional; Region: PLN03044 412022003481 active site 412022003482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003484 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 412022003485 substrate binding pocket [chemical binding]; other site 412022003486 dimerization interface [polypeptide binding]; other site 412022003487 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 412022003488 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412022003489 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 412022003490 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 412022003491 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 412022003492 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 412022003493 tetramer interface [polypeptide binding]; other site 412022003494 active site 412022003495 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 412022003496 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 412022003497 benzoate transport; Region: 2A0115; TIGR00895 412022003498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022003499 putative substrate translocation pore; other site 412022003500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022003501 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022003502 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 412022003503 Chromate transporter; Region: Chromate_transp; pfam02417 412022003504 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 412022003505 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 412022003506 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 412022003507 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 412022003508 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 412022003509 RNA polymerase sigma factor; Provisional; Region: PRK11922 412022003510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022003511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022003512 DNA binding residues [nucleotide binding] 412022003513 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 412022003514 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412022003515 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412022003516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022003517 Walker A/P-loop; other site 412022003518 ATP binding site [chemical binding]; other site 412022003519 Q-loop/lid; other site 412022003520 ABC transporter signature motif; other site 412022003521 Walker B; other site 412022003522 D-loop; other site 412022003523 H-loop/switch region; other site 412022003524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022003525 Walker A/P-loop; other site 412022003526 ATP binding site [chemical binding]; other site 412022003527 Q-loop/lid; other site 412022003528 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412022003529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022003530 Walker A/P-loop; other site 412022003531 ATP binding site [chemical binding]; other site 412022003532 Q-loop/lid; other site 412022003533 ABC transporter signature motif; other site 412022003534 Walker B; other site 412022003535 D-loop; other site 412022003536 H-loop/switch region; other site 412022003537 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 412022003538 H-NS histone family; Region: Histone_HNS; pfam00816 412022003539 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022003540 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 412022003541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022003542 putative substrate translocation pore; other site 412022003543 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 412022003544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022003545 dimer interface [polypeptide binding]; other site 412022003546 phosphorylation site [posttranslational modification] 412022003547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022003548 ATP binding site [chemical binding]; other site 412022003549 Mg2+ binding site [ion binding]; other site 412022003550 G-X-G motif; other site 412022003551 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022003552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003553 active site 412022003554 phosphorylation site [posttranslational modification] 412022003555 intermolecular recognition site; other site 412022003556 dimerization interface [polypeptide binding]; other site 412022003557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022003558 Walker A motif; other site 412022003559 ATP binding site [chemical binding]; other site 412022003560 Walker B motif; other site 412022003561 arginine finger; other site 412022003562 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022003563 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 412022003564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022003565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022003566 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 412022003567 Phosphoesterase family; Region: Phosphoesterase; pfam04185 412022003568 Domain of unknown function (DUF756); Region: DUF756; pfam05506 412022003569 Domain of unknown function (DUF756); Region: DUF756; pfam05506 412022003570 Transposase; Region: HTH_Tnp_1; pfam01527 412022003571 HTH-like domain; Region: HTH_21; pfam13276 412022003572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022003573 Integrase core domain; Region: rve; pfam00665 412022003574 Integrase core domain; Region: rve_3; pfam13683 412022003575 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 412022003576 Chain length determinant protein; Region: Wzz; pfam02706 412022003577 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 412022003578 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 412022003579 Phospholipid methyltransferase; Region: PEMT; cl17370 412022003580 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 412022003581 peptidase domain interface [polypeptide binding]; other site 412022003582 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 412022003583 active site 412022003584 catalytic triad [active] 412022003585 calcium binding site [ion binding]; other site 412022003586 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 412022003587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022003588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022003589 metal binding site [ion binding]; metal-binding site 412022003590 active site 412022003591 I-site; other site 412022003592 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022003593 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 412022003594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 412022003595 short chain dehydrogenase; Provisional; Region: PRK06181 412022003596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022003597 NAD(P) binding site [chemical binding]; other site 412022003598 active site 412022003599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022003600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003602 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022003603 putative effector binding pocket; other site 412022003604 dimerization interface [polypeptide binding]; other site 412022003605 HTH-like domain; Region: HTH_21; pfam13276 412022003606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022003607 Integrase core domain; Region: rve; pfam00665 412022003608 Integrase core domain; Region: rve_3; pfam13683 412022003609 Transposase; Region: HTH_Tnp_1; pfam01527 412022003610 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 412022003611 Asp-box motif; other site 412022003612 Isochorismatase family; Region: Isochorismatase; pfam00857 412022003613 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 412022003614 catalytic triad [active] 412022003615 conserved cis-peptide bond; other site 412022003616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022003617 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 412022003618 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 412022003619 nucleophilic elbow; other site 412022003620 catalytic triad; other site 412022003621 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 412022003622 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 412022003623 putative NAD(P) binding site [chemical binding]; other site 412022003624 active site 412022003625 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 412022003626 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022003627 catalytic loop [active] 412022003628 iron binding site [ion binding]; other site 412022003629 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 412022003630 FAD binding pocket [chemical binding]; other site 412022003631 FAD binding motif [chemical binding]; other site 412022003632 phosphate binding motif [ion binding]; other site 412022003633 beta-alpha-beta structure motif; other site 412022003634 NAD binding pocket [chemical binding]; other site 412022003635 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 412022003636 inter-subunit interface; other site 412022003637 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 412022003638 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 412022003639 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 412022003640 putative alpha subunit interface [polypeptide binding]; other site 412022003641 putative active site [active] 412022003642 putative substrate binding site [chemical binding]; other site 412022003643 Fe binding site [ion binding]; other site 412022003644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003646 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 412022003647 dimerizarion interface [polypeptide binding]; other site 412022003648 CrgA pocket; other site 412022003649 substrate binding pocket [chemical binding]; other site 412022003650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022003651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022003652 NAD(P) binding site [chemical binding]; other site 412022003653 active site 412022003654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022003657 dimerization interface [polypeptide binding]; other site 412022003658 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 412022003659 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022003660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022003661 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412022003662 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 412022003663 active site 412022003664 FMN binding site [chemical binding]; other site 412022003665 2,4-decadienoyl-CoA binding site; other site 412022003666 catalytic residue [active] 412022003667 4Fe-4S cluster binding site [ion binding]; other site 412022003668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 412022003669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022003670 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 412022003671 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 412022003672 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 412022003673 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412022003674 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 412022003675 D-pathway; other site 412022003676 Putative ubiquinol binding site [chemical binding]; other site 412022003677 Low-spin heme (heme b) binding site [chemical binding]; other site 412022003678 Putative water exit pathway; other site 412022003679 Binuclear center (heme o3/CuB) [ion binding]; other site 412022003680 K-pathway; other site 412022003681 Putative proton exit pathway; other site 412022003682 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 412022003683 Subunit I/III interface [polypeptide binding]; other site 412022003684 Subunit III/IV interface [polypeptide binding]; other site 412022003685 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 412022003686 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 412022003687 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 412022003688 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 412022003689 dimer interface [polypeptide binding]; other site 412022003690 active site 412022003691 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 412022003692 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 412022003693 octamer interface [polypeptide binding]; other site 412022003694 active site 412022003695 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 412022003696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022003698 dimerization interface [polypeptide binding]; other site 412022003699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022003700 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 412022003701 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 412022003702 putative alpha subunit interface [polypeptide binding]; other site 412022003703 putative active site [active] 412022003704 putative substrate binding site [chemical binding]; other site 412022003705 Fe binding site [ion binding]; other site 412022003706 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 412022003707 inter-subunit interface; other site 412022003708 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 412022003709 [2Fe-2S] cluster binding site [ion binding]; other site 412022003710 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 412022003711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022003712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022003713 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 412022003714 HIT family signature motif; other site 412022003715 catalytic residue [active] 412022003716 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 412022003717 PLD-like domain; Region: PLDc_2; pfam13091 412022003718 putative active site [active] 412022003719 catalytic site [active] 412022003720 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 412022003721 PLD-like domain; Region: PLDc_2; pfam13091 412022003722 putative active site [active] 412022003723 catalytic site [active] 412022003724 Protein of unknown function (DUF445); Region: DUF445; pfam04286 412022003725 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 412022003726 acetolactate synthase; Reviewed; Region: PRK08322 412022003727 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022003728 PYR/PP interface [polypeptide binding]; other site 412022003729 dimer interface [polypeptide binding]; other site 412022003730 TPP binding site [chemical binding]; other site 412022003731 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022003732 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 412022003733 TPP-binding site [chemical binding]; other site 412022003734 dimer interface [polypeptide binding]; other site 412022003735 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 412022003736 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022003737 NAD(P) binding site [chemical binding]; other site 412022003738 catalytic residues [active] 412022003739 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 412022003740 active site 412022003741 catalytic site [active] 412022003742 Response regulator receiver domain; Region: Response_reg; pfam00072 412022003743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003744 active site 412022003745 phosphorylation site [posttranslational modification] 412022003746 intermolecular recognition site; other site 412022003747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022003748 dimerization interface [polypeptide binding]; other site 412022003749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022003750 dimer interface [polypeptide binding]; other site 412022003751 phosphorylation site [posttranslational modification] 412022003752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022003753 ATP binding site [chemical binding]; other site 412022003754 Mg2+ binding site [ion binding]; other site 412022003755 G-X-G motif; other site 412022003756 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 412022003757 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 412022003758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022003759 dimerization interface [polypeptide binding]; other site 412022003760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022003761 dimer interface [polypeptide binding]; other site 412022003762 putative CheW interface [polypeptide binding]; other site 412022003763 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 412022003764 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 412022003765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022003766 S-adenosylmethionine binding site [chemical binding]; other site 412022003767 TPR repeat; Region: TPR_11; pfam13414 412022003768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022003769 binding surface 412022003770 TPR motif; other site 412022003771 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 412022003772 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 412022003773 putative binding surface; other site 412022003774 active site 412022003775 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 412022003776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022003777 ATP binding site [chemical binding]; other site 412022003778 Mg2+ binding site [ion binding]; other site 412022003779 G-X-G motif; other site 412022003780 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 412022003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003782 Response regulator receiver domain; Region: Response_reg; pfam00072 412022003783 active site 412022003784 phosphorylation site [posttranslational modification] 412022003785 intermolecular recognition site; other site 412022003786 dimerization interface [polypeptide binding]; other site 412022003787 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 412022003788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022003789 active site 412022003790 phosphorylation site [posttranslational modification] 412022003791 intermolecular recognition site; other site 412022003792 CheB methylesterase; Region: CheB_methylest; pfam01339 412022003793 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 412022003794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022003795 motif II; other site 412022003796 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 412022003797 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 412022003798 Cl- selectivity filter; other site 412022003799 Cl- binding residues [ion binding]; other site 412022003800 pore gating glutamate residue; other site 412022003801 dimer interface [polypeptide binding]; other site 412022003802 CAAX protease self-immunity; Region: Abi; pfam02517 412022003803 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 412022003804 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 412022003805 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 412022003806 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 412022003807 active site 412022003808 HIGH motif; other site 412022003809 dimer interface [polypeptide binding]; other site 412022003810 KMSKS motif; other site 412022003811 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 412022003812 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022003813 conserved cys residue [active] 412022003814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022003815 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 412022003816 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 412022003817 conserved cys residue [active] 412022003818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412022003819 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 412022003820 Walker A/P-loop; other site 412022003821 ATP binding site [chemical binding]; other site 412022003822 Q-loop/lid; other site 412022003823 ABC transporter signature motif; other site 412022003824 Walker B; other site 412022003825 D-loop; other site 412022003826 H-loop/switch region; other site 412022003827 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 412022003828 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 412022003829 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 412022003830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003832 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 412022003833 substrate binding pocket [chemical binding]; other site 412022003834 dimerization interface [polypeptide binding]; other site 412022003835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022003836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022003837 active site 412022003838 Phosphotransferase enzyme family; Region: APH; pfam01636 412022003839 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 412022003840 putative active site [active] 412022003841 putative substrate binding site [chemical binding]; other site 412022003842 ATP binding site [chemical binding]; other site 412022003843 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412022003844 catalytic core [active] 412022003845 short chain dehydrogenase; Provisional; Region: PRK07035 412022003846 classical (c) SDRs; Region: SDR_c; cd05233 412022003847 NAD(P) binding site [chemical binding]; other site 412022003848 active site 412022003849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022003850 short chain dehydrogenase; Validated; Region: PRK07069 412022003851 NAD(P) binding site [chemical binding]; other site 412022003852 active site 412022003853 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 412022003854 Prostaglandin dehydrogenases; Region: PGDH; cd05288 412022003855 NAD(P) binding site [chemical binding]; other site 412022003856 substrate binding site [chemical binding]; other site 412022003857 dimer interface [polypeptide binding]; other site 412022003858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022003859 putative substrate translocation pore; other site 412022003860 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022003861 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 412022003862 N-terminal plug; other site 412022003863 ligand-binding site [chemical binding]; other site 412022003864 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412022003865 Domain of unknown function DUF20; Region: UPF0118; pfam01594 412022003866 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 412022003867 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 412022003868 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 412022003869 generic binding surface I; other site 412022003870 generic binding surface II; other site 412022003871 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 412022003872 putative active site [active] 412022003873 putative catalytic site [active] 412022003874 putative Mg binding site IVb [ion binding]; other site 412022003875 putative phosphate binding site [ion binding]; other site 412022003876 putative DNA binding site [nucleotide binding]; other site 412022003877 putative Mg binding site IVa [ion binding]; other site 412022003878 YCII-related domain; Region: YCII; cl00999 412022003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 412022003880 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 412022003881 putative hydrophobic ligand binding site [chemical binding]; other site 412022003882 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 412022003883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022003884 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 412022003885 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412022003886 amidase catalytic site [active] 412022003887 Zn binding residues [ion binding]; other site 412022003888 substrate binding site [chemical binding]; other site 412022003889 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 412022003890 Rubrerythrin [Energy production and conversion]; Region: COG1592 412022003891 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 412022003892 binuclear metal center [ion binding]; other site 412022003893 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412022003894 Cysteine-rich domain; Region: CCG; pfam02754 412022003895 Cysteine-rich domain; Region: CCG; pfam02754 412022003896 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 412022003897 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 412022003898 Cupin domain; Region: Cupin_2; cl17218 412022003899 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 412022003900 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 412022003901 Substrate binding site; other site 412022003902 Cupin domain; Region: Cupin_2; cl17218 412022003903 CoA-binding domain; Region: CoA_binding_3; pfam13727 412022003904 Bacterial sugar transferase; Region: Bac_transf; cl00939 412022003905 Transposase; Region: HTH_Tnp_1; pfam01527 412022003906 HTH-like domain; Region: HTH_21; pfam13276 412022003907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022003908 Integrase core domain; Region: rve; pfam00665 412022003909 Integrase core domain; Region: rve_3; pfam13683 412022003910 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022003911 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022003912 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022003913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022003914 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022003915 Homeodomain-like domain; Region: HTH_23; pfam13384 412022003916 Winged helix-turn helix; Region: HTH_29; pfam13551 412022003917 Winged helix-turn helix; Region: HTH_33; pfam13592 412022003918 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412022003919 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 412022003920 phosphate binding site [ion binding]; other site 412022003921 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 412022003922 putative deacylase active site [active] 412022003923 Methyltransferase domain; Region: Methyltransf_11; pfam08241 412022003924 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 412022003925 DNA binding residues [nucleotide binding] 412022003926 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 412022003927 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 412022003928 active site 412022003929 catalytic site [active] 412022003930 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 412022003931 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412022003932 thiamine phosphate binding site [chemical binding]; other site 412022003933 active site 412022003934 pyrophosphate binding site [ion binding]; other site 412022003935 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 412022003936 Domain of unknown function DUF21; Region: DUF21; pfam01595 412022003937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412022003938 Transporter associated domain; Region: CorC_HlyC; smart01091 412022003939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022003940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022003941 dimer interface [polypeptide binding]; other site 412022003942 phosphorylation site [posttranslational modification] 412022003943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 412022003944 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022003945 EamA-like transporter family; Region: EamA; pfam00892 412022003946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022003947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022003948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022003949 dimerization interface [polypeptide binding]; other site 412022003950 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 412022003951 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 412022003952 dimer interface [polypeptide binding]; other site 412022003953 hexamer interface [polypeptide binding]; other site 412022003954 active site 2 [active] 412022003955 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 412022003956 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 412022003957 molybdenum-pterin binding domain; Region: Mop; TIGR00638 412022003958 TOBE domain; Region: TOBE; cl01440 412022003959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022003960 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 412022003961 Walker A/P-loop; other site 412022003962 ATP binding site [chemical binding]; other site 412022003963 Q-loop/lid; other site 412022003964 ABC transporter signature motif; other site 412022003965 Walker B; other site 412022003966 D-loop; other site 412022003967 H-loop/switch region; other site 412022003968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022003969 putative PBP binding loops; other site 412022003970 dimer interface [polypeptide binding]; other site 412022003971 ABC-ATPase subunit interface; other site 412022003972 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 412022003973 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412022003974 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 412022003975 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 412022003976 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 412022003977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022003978 MarR family; Region: MarR; pfam01047 412022003979 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 412022003980 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 412022003981 putative active site [active] 412022003982 putative substrate binding site [chemical binding]; other site 412022003983 ATP binding site [chemical binding]; other site 412022003984 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 412022003985 AMP nucleosidase; Provisional; Region: PRK08292 412022003986 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 412022003987 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 412022003988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412022003989 active site 412022003990 Int/Topo IB signature motif; other site 412022003991 DNA binding site [nucleotide binding] 412022003992 HTH-like domain; Region: HTH_21; pfam13276 412022003993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022003994 Integrase core domain; Region: rve; pfam00665 412022003995 Integrase core domain; Region: rve_3; pfam13683 412022003996 Transposase; Region: HTH_Tnp_1; pfam01527 412022003997 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 412022003998 Uncharacterized conserved protein [Function unknown]; Region: COG1683 412022003999 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 412022004000 DNA polymerase I; Provisional; Region: PRK05755 412022004001 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 412022004002 active site 412022004003 metal binding site 1 [ion binding]; metal-binding site 412022004004 putative 5' ssDNA interaction site; other site 412022004005 metal binding site 3; metal-binding site 412022004006 metal binding site 2 [ion binding]; metal-binding site 412022004007 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 412022004008 putative DNA binding site [nucleotide binding]; other site 412022004009 putative metal binding site [ion binding]; other site 412022004010 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 412022004011 active site 412022004012 catalytic site [active] 412022004013 substrate binding site [chemical binding]; other site 412022004014 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 412022004015 active site 412022004016 DNA binding site [nucleotide binding] 412022004017 catalytic site [active] 412022004018 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 412022004019 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022004020 Predicted membrane protein [Function unknown]; Region: COG4655 412022004021 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 412022004022 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 412022004023 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 412022004024 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 412022004025 active site residue [active] 412022004026 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 412022004027 active site residue [active] 412022004028 Transposase domain (DUF772); Region: DUF772; pfam05598 412022004029 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022004030 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022004031 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 412022004032 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 412022004033 [2Fe-2S] cluster binding site [ion binding]; other site 412022004034 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 412022004035 alpha subunit interface [polypeptide binding]; other site 412022004036 active site 412022004037 substrate binding site [chemical binding]; other site 412022004038 Fe binding site [ion binding]; other site 412022004039 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 412022004040 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412022004041 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412022004042 substrate binding pocket [chemical binding]; other site 412022004043 chain length determination region; other site 412022004044 substrate-Mg2+ binding site; other site 412022004045 catalytic residues [active] 412022004046 aspartate-rich region 1; other site 412022004047 active site lid residues [active] 412022004048 aspartate-rich region 2; other site 412022004049 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 412022004050 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 412022004051 TPP-binding site; other site 412022004052 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412022004053 PYR/PP interface [polypeptide binding]; other site 412022004054 dimer interface [polypeptide binding]; other site 412022004055 TPP binding site [chemical binding]; other site 412022004056 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412022004057 putative GTP cyclohydrolase; Provisional; Region: PRK13674 412022004058 UGMP family protein; Validated; Region: PRK09604 412022004059 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 412022004060 Predicted flavoproteins [General function prediction only]; Region: COG2081 412022004061 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 412022004062 Yqey-like protein; Region: YqeY; pfam09424 412022004063 DNA primase; Validated; Region: dnaG; PRK05667 412022004064 CHC2 zinc finger; Region: zf-CHC2; pfam01807 412022004065 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 412022004066 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 412022004067 active site 412022004068 metal binding site [ion binding]; metal-binding site 412022004069 interdomain interaction site; other site 412022004070 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 412022004071 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 412022004072 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 412022004073 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 412022004074 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412022004075 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 412022004076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022004077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412022004078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022004079 DNA binding residues [nucleotide binding] 412022004080 HTH-like domain; Region: HTH_21; pfam13276 412022004081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004082 Integrase core domain; Region: rve; pfam00665 412022004083 Integrase core domain; Region: rve_3; pfam13683 412022004084 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 412022004085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004086 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 412022004087 substrate binding pocket [chemical binding]; other site 412022004088 dimerization interface [polypeptide binding]; other site 412022004089 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 412022004090 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 412022004091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004092 putative substrate translocation pore; other site 412022004093 POT family; Region: PTR2; cl17359 412022004094 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 412022004095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022004096 non-specific DNA binding site [nucleotide binding]; other site 412022004097 salt bridge; other site 412022004098 sequence-specific DNA binding site [nucleotide binding]; other site 412022004099 Cupin domain; Region: Cupin_2; pfam07883 412022004100 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 412022004101 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412022004102 peptide binding site [polypeptide binding]; other site 412022004103 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 412022004104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022004105 dimer interface [polypeptide binding]; other site 412022004106 conserved gate region; other site 412022004107 putative PBP binding loops; other site 412022004108 ABC-ATPase subunit interface; other site 412022004109 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 412022004110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022004111 dimer interface [polypeptide binding]; other site 412022004112 conserved gate region; other site 412022004113 putative PBP binding loops; other site 412022004114 ABC-ATPase subunit interface; other site 412022004115 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412022004116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022004117 Walker A/P-loop; other site 412022004118 ATP binding site [chemical binding]; other site 412022004119 Q-loop/lid; other site 412022004120 ABC transporter signature motif; other site 412022004121 Walker B; other site 412022004122 D-loop; other site 412022004123 H-loop/switch region; other site 412022004124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022004125 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 412022004126 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022004127 Walker A/P-loop; other site 412022004128 ATP binding site [chemical binding]; other site 412022004129 Q-loop/lid; other site 412022004130 ABC transporter signature motif; other site 412022004131 Walker B; other site 412022004132 D-loop; other site 412022004133 H-loop/switch region; other site 412022004134 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022004135 outer membrane porin, OprD family; Region: OprD; pfam03573 412022004136 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412022004137 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412022004138 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 412022004139 active site residue [active] 412022004140 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 412022004141 PAS fold; Region: PAS_4; pfam08448 412022004142 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022004143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022004144 Walker B motif; other site 412022004145 arginine finger; other site 412022004146 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022004147 H-NS histone family; Region: Histone_HNS; pfam00816 412022004148 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022004149 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 412022004150 CoA binding domain; Region: CoA_binding_2; pfam13380 412022004151 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 412022004152 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 412022004153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412022004154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022004155 Coenzyme A binding pocket [chemical binding]; other site 412022004156 indole acetimide hydrolase; Validated; Region: PRK07488 412022004157 Amidase; Region: Amidase; pfam01425 412022004158 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022004159 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 412022004160 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022004161 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 412022004162 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412022004163 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 412022004164 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412022004165 phosphate binding site [ion binding]; other site 412022004166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004167 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022004168 dimerization interface [polypeptide binding]; other site 412022004169 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022004170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004171 putative substrate translocation pore; other site 412022004172 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 412022004173 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 412022004174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022004175 catalytic residue [active] 412022004176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022004178 putative substrate translocation pore; other site 412022004179 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 412022004180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022004181 dimerization interface [polypeptide binding]; other site 412022004182 putative DNA binding site [nucleotide binding]; other site 412022004183 putative Zn2+ binding site [ion binding]; other site 412022004184 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412022004185 active site residue [active] 412022004186 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022004187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022004189 dimerization interface [polypeptide binding]; other site 412022004190 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 412022004191 catalytic residue [active] 412022004192 D-serine dehydratase; Provisional; Region: PRK02991 412022004193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022004194 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022004195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004196 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 412022004197 dimerization interface [polypeptide binding]; other site 412022004198 substrate binding pocket [chemical binding]; other site 412022004199 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 412022004200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022004201 NAD(P) binding site [chemical binding]; other site 412022004202 active site 412022004203 hypothetical protein; Provisional; Region: PRK07538 412022004204 hypothetical protein; Provisional; Region: PRK07236 412022004205 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 412022004206 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 412022004207 phosphopeptide binding site; other site 412022004208 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 412022004209 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 412022004210 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 412022004211 hypothetical protein; Provisional; Region: PRK07033 412022004212 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 412022004213 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022004214 ligand binding site [chemical binding]; other site 412022004215 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 412022004216 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 412022004217 G1 box; other site 412022004218 GTP/Mg2+ binding site [chemical binding]; other site 412022004219 G2 box; other site 412022004220 G3 box; other site 412022004221 Switch II region; other site 412022004222 G4 box; other site 412022004223 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 412022004224 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 412022004225 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 412022004226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 412022004227 Catalytic domain of Protein Kinases; Region: PKc; cd00180 412022004228 active site 412022004229 ATP binding site [chemical binding]; other site 412022004230 substrate binding site [chemical binding]; other site 412022004231 activation loop (A-loop); other site 412022004232 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 412022004233 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 412022004234 Protein of unknown function (DUF770); Region: DUF770; pfam05591 412022004235 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 412022004236 Protein of unknown function (DUF877); Region: DUF877; pfam05943 412022004237 Protein of unknown function (DUF796); Region: DUF796; pfam05638 412022004238 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 412022004239 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 412022004240 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 412022004241 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 412022004242 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 412022004243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022004244 Walker A motif; other site 412022004245 ATP binding site [chemical binding]; other site 412022004246 Walker B motif; other site 412022004247 arginine finger; other site 412022004248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022004249 Walker A motif; other site 412022004250 ATP binding site [chemical binding]; other site 412022004251 Walker B motif; other site 412022004252 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412022004253 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 412022004254 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022004255 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022004256 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 412022004257 RHS Repeat; Region: RHS_repeat; cl11982 412022004258 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 412022004259 RHS Repeat; Region: RHS_repeat; cl11982 412022004260 RHS Repeat; Region: RHS_repeat; cl11982 412022004261 RHS Repeat; Region: RHS_repeat; cl11982 412022004262 RHS Repeat; Region: RHS_repeat; cl11982 412022004263 HTH-like domain; Region: HTH_21; pfam13276 412022004264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004265 Integrase core domain; Region: rve; pfam00665 412022004266 Integrase core domain; Region: rve_3; pfam13683 412022004267 Transposase; Region: HTH_Tnp_1; pfam01527 412022004268 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 412022004269 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 412022004270 NAD-dependent deacetylase; Provisional; Region: PRK05333 412022004271 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 412022004272 Protein of unknown function (DUF938); Region: DUF938; pfam06080 412022004273 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412022004274 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 412022004275 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 412022004276 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022004277 Cupin domain; Region: Cupin_2; cl17218 412022004278 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412022004279 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412022004280 E3 interaction surface; other site 412022004281 lipoyl attachment site [posttranslational modification]; other site 412022004282 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 412022004283 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 412022004284 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 412022004285 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022004286 N-terminal plug; other site 412022004287 ligand-binding site [chemical binding]; other site 412022004288 Lipase (class 2); Region: Lipase_2; pfam01674 412022004289 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 412022004290 PGAP1-like protein; Region: PGAP1; pfam07819 412022004291 lipase chaperone; Provisional; Region: PRK01294 412022004292 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 412022004293 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022004294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022004295 DNA-binding site [nucleotide binding]; DNA binding site 412022004296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022004297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022004298 homodimer interface [polypeptide binding]; other site 412022004299 catalytic residue [active] 412022004300 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412022004301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022004302 Walker A/P-loop; other site 412022004303 ATP binding site [chemical binding]; other site 412022004304 Q-loop/lid; other site 412022004305 ABC transporter signature motif; other site 412022004306 Walker B; other site 412022004307 D-loop; other site 412022004308 H-loop/switch region; other site 412022004309 TOBE domain; Region: TOBE_2; pfam08402 412022004310 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 412022004311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412022004312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022004313 dimer interface [polypeptide binding]; other site 412022004314 conserved gate region; other site 412022004315 putative PBP binding loops; other site 412022004316 ABC-ATPase subunit interface; other site 412022004317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412022004318 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412022004319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022004320 ABC-ATPase subunit interface; other site 412022004321 putative PBP binding loops; other site 412022004322 HTH-like domain; Region: HTH_21; pfam13276 412022004323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004324 Integrase core domain; Region: rve; pfam00665 412022004325 Integrase core domain; Region: rve_3; pfam13683 412022004326 Transposase; Region: HTH_Tnp_1; pfam01527 412022004327 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 412022004328 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 412022004329 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 412022004330 haemagglutination activity domain; Region: Haemagg_act; pfam05860 412022004331 Inositol polyphosphate kinase; Region: IPK; cl12283 412022004332 aconitate hydratase; Provisional; Region: acnA; PRK12881 412022004333 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 412022004334 substrate binding site [chemical binding]; other site 412022004335 ligand binding site [chemical binding]; other site 412022004336 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 412022004337 substrate binding site [chemical binding]; other site 412022004338 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 412022004339 2-methylcitrate dehydratase; Region: prpD; TIGR02330 412022004340 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 412022004341 malate dehydrogenase; Provisional; Region: PRK05442 412022004342 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 412022004343 NAD(P) binding site [chemical binding]; other site 412022004344 dimer interface [polypeptide binding]; other site 412022004345 malate binding site [chemical binding]; other site 412022004346 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412022004347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022004348 DNA-binding site [nucleotide binding]; DNA binding site 412022004349 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 412022004350 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 412022004351 Iron-sulfur protein interface; other site 412022004352 proximal quinone binding site [chemical binding]; other site 412022004353 SdhD (CybS) interface [polypeptide binding]; other site 412022004354 proximal heme binding site [chemical binding]; other site 412022004355 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 412022004356 SdhC subunit interface [polypeptide binding]; other site 412022004357 proximal heme binding site [chemical binding]; other site 412022004358 cardiolipin binding site; other site 412022004359 Iron-sulfur protein interface; other site 412022004360 proximal quinone binding site [chemical binding]; other site 412022004361 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 412022004362 L-aspartate oxidase; Provisional; Region: PRK06175 412022004363 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412022004364 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 412022004365 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 412022004366 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 412022004367 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 412022004368 dimer interface [polypeptide binding]; other site 412022004369 active site 412022004370 citrylCoA binding site [chemical binding]; other site 412022004371 NADH binding [chemical binding]; other site 412022004372 cationic pore residues; other site 412022004373 oxalacetate/citrate binding site [chemical binding]; other site 412022004374 coenzyme A binding site [chemical binding]; other site 412022004375 catalytic triad [active] 412022004376 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022004377 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022004378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412022004379 HTH-like domain; Region: HTH_21; pfam13276 412022004380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004381 Integrase core domain; Region: rve; pfam00665 412022004382 Integrase core domain; Region: rve_3; pfam13683 412022004383 Transposase; Region: HTH_Tnp_1; pfam01527 412022004384 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 412022004385 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 412022004386 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 412022004387 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 412022004388 dimer interface [polypeptide binding]; other site 412022004389 TPP-binding site [chemical binding]; other site 412022004390 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 412022004391 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022004392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022004393 putative DNA binding site [nucleotide binding]; other site 412022004394 putative Zn2+ binding site [ion binding]; other site 412022004395 AsnC family; Region: AsnC_trans_reg; pfam01037 412022004396 cyclase homology domain; Region: CHD; cd07302 412022004397 nucleotidyl binding site; other site 412022004398 metal binding site [ion binding]; metal-binding site 412022004399 dimer interface [polypeptide binding]; other site 412022004400 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 412022004401 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 412022004402 active site 412022004403 non-prolyl cis peptide bond; other site 412022004404 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 412022004405 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 412022004406 substrate binding site [chemical binding]; other site 412022004407 ligand binding site [chemical binding]; other site 412022004408 Predicted small secreted protein [Function unknown]; Region: COG5510 412022004409 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 412022004410 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 412022004411 substrate binding site [chemical binding]; other site 412022004412 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 412022004413 tartrate dehydrogenase; Region: TTC; TIGR02089 412022004414 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 412022004415 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412022004416 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 412022004417 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 412022004418 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 412022004419 dimerization interface 3.5A [polypeptide binding]; other site 412022004420 active site 412022004421 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 412022004422 active site 412022004423 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 412022004424 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 412022004425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022004426 catalytic residue [active] 412022004427 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 412022004428 DNA methylase; Region: N6_N4_Mtase; pfam01555 412022004429 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 412022004430 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 412022004431 substrate binding site [chemical binding]; other site 412022004432 active site 412022004433 catalytic residues [active] 412022004434 heterodimer interface [polypeptide binding]; other site 412022004435 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 412022004436 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 412022004437 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 412022004438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412022004439 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412022004440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 412022004441 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 412022004442 Colicin V production protein; Region: Colicin_V; pfam02674 412022004443 amidophosphoribosyltransferase; Provisional; Region: PRK09246 412022004444 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 412022004445 active site 412022004446 tetramer interface [polypeptide binding]; other site 412022004447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022004448 active site 412022004449 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 412022004450 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412022004451 homodimer interface [polypeptide binding]; other site 412022004452 substrate-cofactor binding pocket; other site 412022004453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022004454 catalytic residue [active] 412022004455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022004456 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022004457 NAD(P) binding site [chemical binding]; other site 412022004458 active site 412022004459 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 412022004460 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 412022004461 NADP-binding site; other site 412022004462 homotetramer interface [polypeptide binding]; other site 412022004463 substrate binding site [chemical binding]; other site 412022004464 homodimer interface [polypeptide binding]; other site 412022004465 active site 412022004466 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 412022004467 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 412022004468 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 412022004469 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 412022004470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022004471 putative ADP-binding pocket [chemical binding]; other site 412022004472 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 412022004473 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022004474 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 412022004475 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 412022004476 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412022004477 active site 412022004478 tetramer interface; other site 412022004479 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 412022004480 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022004481 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022004482 trimer interface [polypeptide binding]; other site 412022004483 eyelet of channel; other site 412022004484 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 412022004485 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 412022004486 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 412022004487 putative active site [active] 412022004488 Zn binding site [ion binding]; other site 412022004489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022004490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022004491 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022004492 substrate binding pocket [chemical binding]; other site 412022004493 membrane-bound complex binding site; other site 412022004494 hinge residues; other site 412022004495 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 412022004496 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 412022004497 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 412022004498 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 412022004499 active site 412022004500 non-prolyl cis peptide bond; other site 412022004501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022004502 dimer interface [polypeptide binding]; other site 412022004503 conserved gate region; other site 412022004504 putative PBP binding loops; other site 412022004505 ABC-ATPase subunit interface; other site 412022004506 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412022004507 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022004508 Walker A/P-loop; other site 412022004509 ATP binding site [chemical binding]; other site 412022004510 Q-loop/lid; other site 412022004511 ABC transporter signature motif; other site 412022004512 Walker B; other site 412022004513 D-loop; other site 412022004514 H-loop/switch region; other site 412022004515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022004516 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022004517 substrate binding pocket [chemical binding]; other site 412022004518 membrane-bound complex binding site; other site 412022004519 hinge residues; other site 412022004520 Uncharacterized conserved protein [Function unknown]; Region: COG1434 412022004521 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412022004522 putative active site [active] 412022004523 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022004524 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022004525 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022004526 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 412022004527 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 412022004528 molybdopterin cofactor binding site; other site 412022004529 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 412022004530 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 412022004531 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 412022004532 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 412022004533 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 412022004534 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 412022004535 selenocysteine synthase; Provisional; Region: PRK04311 412022004536 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 412022004537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022004538 catalytic residue [active] 412022004539 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 412022004540 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 412022004541 G1 box; other site 412022004542 putative GEF interaction site [polypeptide binding]; other site 412022004543 GTP/Mg2+ binding site [chemical binding]; other site 412022004544 Switch I region; other site 412022004545 G2 box; other site 412022004546 G3 box; other site 412022004547 Switch II region; other site 412022004548 G4 box; other site 412022004549 G5 box; other site 412022004550 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 412022004551 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 412022004552 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 412022004553 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 412022004554 Amidase; Region: Amidase; cl11426 412022004555 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 412022004556 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 412022004557 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 412022004558 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 412022004559 H+ Antiporter protein; Region: 2A0121; TIGR00900 412022004560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004561 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 412022004562 Cytochrome P450; Region: p450; cl12078 412022004563 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 412022004564 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 412022004565 FMN-binding pocket [chemical binding]; other site 412022004566 flavin binding motif; other site 412022004567 phosphate binding motif [ion binding]; other site 412022004568 beta-alpha-beta structure motif; other site 412022004569 NAD binding pocket [chemical binding]; other site 412022004570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022004571 catalytic loop [active] 412022004572 iron binding site [ion binding]; other site 412022004573 benzoate transport; Region: 2A0115; TIGR00895 412022004574 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 412022004575 active site 412022004576 nucleophile elbow; other site 412022004577 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412022004578 Cu(I) binding site [ion binding]; other site 412022004579 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 412022004580 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 412022004581 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 412022004582 putative sugar binding sites [chemical binding]; other site 412022004583 Q-X-W motif; other site 412022004584 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 412022004585 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 412022004586 putative sugar binding sites [chemical binding]; other site 412022004587 Q-X-W motif; other site 412022004588 Kelch motif; Region: Kelch_6; pfam13964 412022004589 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 412022004590 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 412022004591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022004592 active site 412022004593 phosphorylation site [posttranslational modification] 412022004594 intermolecular recognition site; other site 412022004595 dimerization interface [polypeptide binding]; other site 412022004596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412022004597 Zn2+ binding site [ion binding]; other site 412022004598 Mg2+ binding site [ion binding]; other site 412022004599 Uncharacterized conserved protein [Function unknown]; Region: COG3287 412022004600 FIST N domain; Region: FIST; pfam08495 412022004601 FIST C domain; Region: FIST_C; pfam10442 412022004602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022004603 ATP binding site [chemical binding]; other site 412022004604 Mg2+ binding site [ion binding]; other site 412022004605 G-X-G motif; other site 412022004606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 412022004607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004608 putative substrate translocation pore; other site 412022004609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022004610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004611 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022004612 putative effector binding pocket; other site 412022004613 dimerization interface [polypeptide binding]; other site 412022004614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022004615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004616 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 412022004617 putative dimerization interface [polypeptide binding]; other site 412022004618 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 412022004619 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 412022004620 putative active site [active] 412022004621 putative catalytic site [active] 412022004622 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 412022004623 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 412022004624 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 412022004625 pyruvate dehydrogenase; Provisional; Region: PRK09124 412022004626 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 412022004627 PYR/PP interface [polypeptide binding]; other site 412022004628 tetramer interface [polypeptide binding]; other site 412022004629 dimer interface [polypeptide binding]; other site 412022004630 TPP binding site [chemical binding]; other site 412022004631 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022004632 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 412022004633 TPP-binding site [chemical binding]; other site 412022004634 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 412022004635 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022004636 inhibitor-cofactor binding pocket; inhibition site 412022004637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022004638 catalytic residue [active] 412022004639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004640 putative substrate translocation pore; other site 412022004641 Condensation domain; Region: Condensation; pfam00668 412022004642 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022004643 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022004644 acyl-activating enzyme (AAE) consensus motif; other site 412022004645 AMP binding site [chemical binding]; other site 412022004646 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022004647 Condensation domain; Region: Condensation; pfam00668 412022004648 Transposase; Region: HTH_Tnp_1; pfam01527 412022004649 HTH-like domain; Region: HTH_21; pfam13276 412022004650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004651 Integrase core domain; Region: rve; pfam00665 412022004652 Integrase core domain; Region: rve_3; pfam13683 412022004653 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022004654 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022004655 acyl-activating enzyme (AAE) consensus motif; other site 412022004656 AMP binding site [chemical binding]; other site 412022004657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022004658 Condensation domain; Region: Condensation; pfam00668 412022004659 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022004660 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022004661 acyl-activating enzyme (AAE) consensus motif; other site 412022004662 AMP binding site [chemical binding]; other site 412022004663 active site 412022004664 CoA binding site [chemical binding]; other site 412022004665 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022004666 Condensation domain; Region: Condensation; pfam00668 412022004667 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022004668 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022004669 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 412022004670 acyl-activating enzyme (AAE) consensus motif; other site 412022004671 AMP binding site [chemical binding]; other site 412022004672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022004673 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 412022004674 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 412022004675 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022004676 substrate binding pocket [chemical binding]; other site 412022004677 active site 412022004678 iron coordination sites [ion binding]; other site 412022004679 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 412022004680 type III secretion protein HrpB7; Region: HrpB7; TIGR02559 412022004681 type III secretion system ATPase; Provisional; Region: PRK09099 412022004682 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412022004683 Walker A motif; other site 412022004684 ATP binding site [chemical binding]; other site 412022004685 Walker B motif; other site 412022004686 type III secretion system protein HrpB; Validated; Region: PRK09098 412022004687 Flagellar assembly protein FliH; Region: FliH; pfam02108 412022004688 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 412022004689 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 412022004690 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 412022004691 type III secretion protein HrpB2; Region: HrpB2; TIGR02558 412022004692 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 412022004693 type III secretion system protein HrcU; Validated; Region: PRK09108 412022004694 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 412022004695 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 412022004696 FHIPEP family; Region: FHIPEP; pfam00771 412022004697 Type III secretion protein (HpaP); Region: HpaP; cl17849 412022004698 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 412022004699 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 412022004700 type III secretion system protein YscR; Provisional; Region: PRK12797 412022004701 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 412022004702 Tir chaperone protein (CesT) family; Region: CesT; cl08444 412022004703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022004704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022004705 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412022004706 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 412022004707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022004709 ATP binding site [chemical binding]; other site 412022004710 Mg2+ binding site [ion binding]; other site 412022004711 G-X-G motif; other site 412022004712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022004713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022004714 active site 412022004715 phosphorylation site [posttranslational modification] 412022004716 intermolecular recognition site; other site 412022004717 dimerization interface [polypeptide binding]; other site 412022004718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022004719 DNA binding site [nucleotide binding] 412022004720 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 412022004721 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412022004722 Walker A motif; other site 412022004723 ATP binding site [chemical binding]; other site 412022004724 Walker B motif; other site 412022004725 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 412022004726 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 412022004727 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022004728 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 412022004729 Type II/IV secretion system protein; Region: T2SE; pfam00437 412022004730 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412022004731 Walker A motif; other site 412022004732 ATP binding site [chemical binding]; other site 412022004733 Walker B motif; other site 412022004734 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022004735 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022004736 PilS N terminal; Region: PilS; pfam08805 412022004737 PilM; Region: PilM; pfam07419 412022004738 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 412022004739 type II secretion system protein D; Region: type_II_gspD; TIGR02517 412022004740 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022004741 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022004742 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022004743 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 412022004744 agmatinase; Region: agmatinase; TIGR01230 412022004745 oligomer interface [polypeptide binding]; other site 412022004746 putative active site [active] 412022004747 Mn binding site [ion binding]; other site 412022004748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022004749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022004751 dimerization interface [polypeptide binding]; other site 412022004752 HipA N-terminal domain; Region: couple_hipA; TIGR03071 412022004753 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 412022004754 HipA-like N-terminal domain; Region: HipA_N; pfam07805 412022004755 HipA-like C-terminal domain; Region: HipA_C; pfam07804 412022004756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022004757 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412022004758 non-specific DNA binding site [nucleotide binding]; other site 412022004759 salt bridge; other site 412022004760 sequence-specific DNA binding site [nucleotide binding]; other site 412022004761 cellulose synthase regulator protein; Provisional; Region: PRK11114 412022004762 endo-1,4-D-glucanase; Provisional; Region: PRK11097 412022004763 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 412022004764 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 412022004765 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 412022004766 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 412022004767 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 412022004768 DXD motif; other site 412022004769 PilZ domain; Region: PilZ; pfam07238 412022004770 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 412022004771 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022004772 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 412022004773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022004774 membrane-bound complex binding site; other site 412022004775 hinge residues; other site 412022004776 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412022004777 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 412022004778 Walker A/P-loop; other site 412022004779 ATP binding site [chemical binding]; other site 412022004780 Q-loop/lid; other site 412022004781 ABC transporter signature motif; other site 412022004782 Walker B; other site 412022004783 D-loop; other site 412022004784 H-loop/switch region; other site 412022004785 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412022004786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022004787 dimer interface [polypeptide binding]; other site 412022004788 conserved gate region; other site 412022004789 putative PBP binding loops; other site 412022004790 ABC-ATPase subunit interface; other site 412022004791 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 412022004792 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412022004793 putative active site [active] 412022004794 putative FMN binding site [chemical binding]; other site 412022004795 putative substrate binding site [chemical binding]; other site 412022004796 putative catalytic residue [active] 412022004797 Autoinducer synthetase; Region: Autoind_synth; cl17404 412022004798 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022004799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022004800 DNA binding residues [nucleotide binding] 412022004801 dimerization interface [polypeptide binding]; other site 412022004802 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 412022004803 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022004804 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 412022004805 putative AMP binding site [chemical binding]; other site 412022004806 putative active site [active] 412022004807 acyl-activating enzyme (AAE) consensus motif; other site 412022004808 putative CoA binding site [chemical binding]; other site 412022004809 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 412022004810 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 412022004811 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 412022004812 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 412022004813 putative hydrophobic ligand binding site [chemical binding]; other site 412022004814 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022004815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022004816 putative DNA binding site [nucleotide binding]; other site 412022004817 putative Zn2+ binding site [ion binding]; other site 412022004818 AsnC family; Region: AsnC_trans_reg; pfam01037 412022004819 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022004820 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 412022004821 peptidase domain interface [polypeptide binding]; other site 412022004822 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 412022004823 active site 412022004824 catalytic triad [active] 412022004825 calcium binding site [ion binding]; other site 412022004826 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 412022004827 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 412022004828 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 412022004829 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412022004830 phosphate binding site [ion binding]; other site 412022004831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022004832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022004834 dimerization interface [polypeptide binding]; other site 412022004835 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 412022004836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004837 putative substrate translocation pore; other site 412022004838 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 412022004839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022004840 dimer interface [polypeptide binding]; other site 412022004841 putative metal binding site [ion binding]; other site 412022004842 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022004843 MarR family; Region: MarR_2; cl17246 412022004844 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412022004845 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412022004846 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 412022004847 active site 412022004848 Zn binding site [ion binding]; other site 412022004849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 412022004850 DNA binding site [nucleotide binding] 412022004851 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 412022004852 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 412022004853 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 412022004854 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 412022004855 Type III secretion needle MxiH like; Region: MxiH; cl09641 412022004856 type III secretion system protein PrgH/EprH; Region: PrgH; TIGR02554 412022004857 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 412022004858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022004859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022004860 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022004861 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022004862 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 412022004863 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022004864 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 412022004865 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 412022004866 type III secretion system protein InvA; Provisional; Region: PRK15337 412022004867 Invasion protein B family; Region: Invas_SpaK; cl04129 412022004868 ATP synthase SpaL; Validated; Region: PRK08149 412022004869 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412022004870 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412022004871 Walker A motif; other site 412022004872 ATP binding site [chemical binding]; other site 412022004873 Walker B motif; other site 412022004874 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 412022004875 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 412022004876 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 412022004877 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 412022004878 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 412022004879 type III secretion system protein SpaS; Validated; Region: PRK08156 412022004880 chaperone protein SicA; Provisional; Region: PRK15331 412022004881 Tetratricopeptide repeat; Region: TPR_3; pfam07720 412022004882 Tetratricopeptide repeat; Region: TPR_3; pfam07720 412022004883 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 412022004884 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; pfam09599 412022004885 H-NS histone family; Region: Histone_HNS; pfam00816 412022004886 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022004887 type III effector protein IpaD/SipD/SspD; Region: SipD_IpaD_SspD; TIGR02553 412022004888 Phosphopantetheine attachment site; Region: PP-binding; cl09936 412022004889 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 412022004890 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412022004891 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412022004892 catalytic residue [active] 412022004893 type III secretion protein BopE; Provisional; Region: PRK15278 412022004894 SopE GEF domain; Region: SopE_GEF; pfam07487 412022004895 SicP binding; Region: SicP-binding; pfam09119 412022004896 chaperone protein SicP; Provisional; Region: PRK15329 412022004897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022004898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022004899 active site 412022004900 phosphorylation site [posttranslational modification] 412022004901 intermolecular recognition site; other site 412022004902 dimerization interface [polypeptide binding]; other site 412022004903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022004904 DNA binding residues [nucleotide binding] 412022004905 dimerization interface [polypeptide binding]; other site 412022004906 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022004907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022004908 HTH-like domain; Region: HTH_21; pfam13276 412022004909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004910 Integrase core domain; Region: rve; pfam00665 412022004911 Integrase core domain; Region: rve_3; pfam13683 412022004912 Transposase; Region: HTH_Tnp_1; pfam01527 412022004913 Hemin uptake protein hemP; Region: hemP; pfam10636 412022004914 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 412022004915 putative hydrophobic ligand binding site [chemical binding]; other site 412022004916 Pirin-related protein [General function prediction only]; Region: COG1741 412022004917 Pirin; Region: Pirin; pfam02678 412022004918 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 412022004919 LysR family transcriptional regulator; Provisional; Region: PRK14997 412022004920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004921 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 412022004922 putative effector binding pocket; other site 412022004923 putative dimerization interface [polypeptide binding]; other site 412022004924 Transposase domain (DUF772); Region: DUF772; pfam05598 412022004925 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022004926 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022004927 Transposase; Region: HTH_Tnp_1; pfam01527 412022004928 HTH-like domain; Region: HTH_21; pfam13276 412022004929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022004930 Integrase core domain; Region: rve; pfam00665 412022004931 Integrase core domain; Region: rve_3; pfam13683 412022004932 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412022004933 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412022004934 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 412022004935 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 412022004936 active site 412022004937 Zn binding site [ion binding]; other site 412022004938 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 412022004939 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022004940 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022004941 substrate binding pocket [chemical binding]; other site 412022004942 membrane-bound complex binding site; other site 412022004943 hinge residues; other site 412022004944 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 412022004945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022004946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022004947 dimerization interface [polypeptide binding]; other site 412022004948 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412022004949 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 412022004950 metal binding site [ion binding]; metal-binding site 412022004951 putative dimer interface [polypeptide binding]; other site 412022004952 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022004953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022004954 putative substrate translocation pore; other site 412022004955 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 412022004956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022004957 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 412022004958 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 412022004959 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022004960 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022004961 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 412022004962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022004963 dimer interface [polypeptide binding]; other site 412022004964 active site 412022004965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022004966 PAS domain; Region: PAS_9; pfam13426 412022004967 putative active site [active] 412022004968 heme pocket [chemical binding]; other site 412022004969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022004970 dimer interface [polypeptide binding]; other site 412022004971 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 412022004972 putative CheW interface [polypeptide binding]; other site 412022004973 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 412022004974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022004975 S-adenosylmethionine binding site [chemical binding]; other site 412022004976 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 412022004977 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 412022004978 hydrophobic ligand binding site; other site 412022004979 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 412022004980 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 412022004981 iron-sulfur cluster [ion binding]; other site 412022004982 [2Fe-2S] cluster binding site [ion binding]; other site 412022004983 succinic semialdehyde dehydrogenase; Region: PLN02278 412022004984 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 412022004985 tetramerization interface [polypeptide binding]; other site 412022004986 NAD(P) binding site [chemical binding]; other site 412022004987 catalytic residues [active] 412022004988 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 412022004989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022004990 inhibitor-cofactor binding pocket; inhibition site 412022004991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022004992 catalytic residue [active] 412022004993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022004994 DNA-binding site [nucleotide binding]; DNA binding site 412022004995 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022004996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022004997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022004998 homodimer interface [polypeptide binding]; other site 412022004999 catalytic residue [active] 412022005000 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 412022005001 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 412022005002 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 412022005003 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022005004 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022005005 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 412022005006 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 412022005007 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 412022005008 EamA-like transporter family; Region: EamA; cl17759 412022005009 selenophosphate synthetase; Provisional; Region: PRK00943 412022005010 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 412022005011 dimerization interface [polypeptide binding]; other site 412022005012 putative ATP binding site [chemical binding]; other site 412022005013 Purine nucleoside permease (NUP); Region: NUP; pfam06516 412022005014 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 412022005015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022005016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022005017 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 412022005018 putative effector binding pocket; other site 412022005019 putative dimerization interface [polypeptide binding]; other site 412022005020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 412022005021 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 412022005022 substrate binding pocket [chemical binding]; other site 412022005023 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412022005024 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022005025 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022005026 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412022005027 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022005028 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412022005029 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 412022005030 Transcriptional regulators [Transcription]; Region: GntR; COG1802 412022005031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022005032 DNA-binding site [nucleotide binding]; DNA binding site 412022005033 FCD domain; Region: FCD; pfam07729 412022005034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022005035 Coenzyme A binding pocket [chemical binding]; other site 412022005036 Membrane transport protein; Region: Mem_trans; cl09117 412022005037 acyl-CoA synthetase; Validated; Region: PRK05850 412022005038 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 412022005039 acyl-activating enzyme (AAE) consensus motif; other site 412022005040 active site 412022005041 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 412022005042 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412022005043 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 412022005044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022005045 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 412022005046 acyl-activating enzyme (AAE) consensus motif; other site 412022005047 AMP binding site [chemical binding]; other site 412022005048 active site 412022005049 CoA binding site [chemical binding]; other site 412022005050 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 412022005051 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 412022005052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022005053 catalytic residue [active] 412022005054 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 412022005055 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 412022005056 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 412022005057 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 412022005058 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022005059 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022005060 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 412022005061 active site 412022005062 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 412022005063 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 412022005064 putative NADP binding site [chemical binding]; other site 412022005065 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 412022005066 active site 412022005067 Methyltransferase domain; Region: Methyltransf_12; pfam08242 412022005068 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412022005069 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022005070 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 412022005071 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022005072 active site 412022005073 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022005074 Condensation domain; Region: Condensation; pfam00668 412022005075 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022005076 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022005077 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022005078 thioester reductase domain; Region: Thioester-redct; TIGR01746 412022005079 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 412022005080 putative NAD(P) binding site [chemical binding]; other site 412022005081 active site 412022005082 putative substrate binding site [chemical binding]; other site 412022005083 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 412022005084 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022005085 NAD(P) binding site [chemical binding]; other site 412022005086 catalytic residues [active] 412022005087 hypothetical protein; Provisional; Region: PRK07036 412022005088 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022005089 inhibitor-cofactor binding pocket; inhibition site 412022005090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022005091 catalytic residue [active] 412022005092 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022005093 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 412022005094 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 412022005095 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 412022005096 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022005097 AMP-binding enzyme; Region: AMP-binding; pfam00501 412022005098 acyl-activating enzyme (AAE) consensus motif; other site 412022005099 AMP binding site [chemical binding]; other site 412022005100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022005101 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 412022005102 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022005103 active site 412022005104 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412022005105 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 412022005106 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 412022005107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022005108 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 412022005109 NAD(P) binding site [chemical binding]; other site 412022005110 active site 412022005111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022005112 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022005113 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022005114 DNA binding residues [nucleotide binding] 412022005115 dimerization interface [polypeptide binding]; other site 412022005116 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412022005117 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 412022005118 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 412022005119 active site 412022005120 non-prolyl cis peptide bond; other site 412022005121 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 412022005122 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 412022005123 Walker A/P-loop; other site 412022005124 ATP binding site [chemical binding]; other site 412022005125 Q-loop/lid; other site 412022005126 ABC transporter signature motif; other site 412022005127 Walker B; other site 412022005128 D-loop; other site 412022005129 H-loop/switch region; other site 412022005130 NIL domain; Region: NIL; pfam09383 412022005131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022005132 dimer interface [polypeptide binding]; other site 412022005133 conserved gate region; other site 412022005134 ABC-ATPase subunit interface; other site 412022005135 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 412022005136 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 412022005137 Flavin binding site [chemical binding]; other site 412022005138 transcriptional regulator NanR; Provisional; Region: PRK03837 412022005139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022005140 DNA-binding site [nucleotide binding]; DNA binding site 412022005141 FCD domain; Region: FCD; pfam07729 412022005142 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412022005143 Cysteine-rich domain; Region: CCG; pfam02754 412022005144 Cysteine-rich domain; Region: CCG; pfam02754 412022005145 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 412022005146 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 412022005147 4Fe-4S binding domain; Region: Fer4; pfam00037 412022005148 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 412022005149 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 412022005150 glycolate transporter; Provisional; Region: PRK09695 412022005151 L-lactate permease; Region: Lactate_perm; cl00701 412022005152 Predicted membrane protein [Function unknown]; Region: COG2259 412022005153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005154 putative substrate translocation pore; other site 412022005155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005156 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022005157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005158 putative substrate translocation pore; other site 412022005159 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 412022005160 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 412022005161 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 412022005162 dimer interface [polypeptide binding]; other site 412022005163 NADP binding site [chemical binding]; other site 412022005164 catalytic residues [active] 412022005165 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 412022005166 Spore germination protein; Region: Spore_permease; cl17796 412022005167 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 412022005168 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 412022005169 inhibitor site; inhibition site 412022005170 active site 412022005171 dimer interface [polypeptide binding]; other site 412022005172 catalytic residue [active] 412022005173 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 412022005174 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 412022005175 FAD dependent oxidoreductase; Region: DAO; pfam01266 412022005176 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412022005177 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 412022005178 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 412022005179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 412022005180 PAS fold; Region: PAS_4; pfam08448 412022005181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 412022005182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022005183 HTH-like domain; Region: HTH_21; pfam13276 412022005184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022005185 Integrase core domain; Region: rve; pfam00665 412022005186 Integrase core domain; Region: rve_3; pfam13683 412022005187 Transposase; Region: HTH_Tnp_1; pfam01527 412022005188 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 412022005189 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 412022005190 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 412022005191 dimer interface [polypeptide binding]; other site 412022005192 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 412022005193 active site 412022005194 Fe binding site [ion binding]; other site 412022005195 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 412022005196 Dehydroquinase class II; Region: DHquinase_II; pfam01220 412022005197 active site 412022005198 trimer interface [polypeptide binding]; other site 412022005199 dimer interface [polypeptide binding]; other site 412022005200 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 412022005201 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 412022005202 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 412022005203 shikimate binding site; other site 412022005204 NAD(P) binding site [chemical binding]; other site 412022005205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005206 D-galactonate transporter; Region: 2A0114; TIGR00893 412022005207 putative substrate translocation pore; other site 412022005208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005209 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 412022005210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022005211 catalytic residue [active] 412022005212 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 412022005213 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412022005214 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 412022005215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022005216 Walker A/P-loop; other site 412022005217 ATP binding site [chemical binding]; other site 412022005218 Q-loop/lid; other site 412022005219 ABC transporter signature motif; other site 412022005220 Walker B; other site 412022005221 D-loop; other site 412022005222 H-loop/switch region; other site 412022005223 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 412022005224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022005225 dimer interface [polypeptide binding]; other site 412022005226 conserved gate region; other site 412022005227 putative PBP binding loops; other site 412022005228 ABC-ATPase subunit interface; other site 412022005229 2-aminoethylphosphonate ABC transport system, membrane component PhnV; Region: PhnV; TIGR03255 412022005230 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 412022005231 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 412022005232 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 412022005233 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 412022005234 NAD(P) binding site [chemical binding]; other site 412022005235 catalytic residues [active] 412022005236 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 412022005237 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 412022005238 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 412022005239 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 412022005240 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 412022005241 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 412022005242 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 412022005243 replicative DNA helicase; Provisional; Region: PRK07004 412022005244 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 412022005245 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 412022005246 Walker A motif; other site 412022005247 ATP binding site [chemical binding]; other site 412022005248 Walker B motif; other site 412022005249 DNA binding loops [nucleotide binding] 412022005250 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 412022005251 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 412022005252 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 412022005253 NlpC/P60 family; Region: NLPC_P60; pfam00877 412022005254 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 412022005255 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 412022005256 putative active site [active] 412022005257 PhoH-like protein; Region: PhoH; pfam02562 412022005258 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 412022005259 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022005260 catalytic triad [active] 412022005261 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 412022005262 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 412022005263 putative active site [active] 412022005264 putative catalytic site [active] 412022005265 putative Zn binding site [ion binding]; other site 412022005266 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 412022005267 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 412022005268 NAD binding site [chemical binding]; other site 412022005269 substrate binding site [chemical binding]; other site 412022005270 active site 412022005271 putative formyltransferase; Provisional; Region: PRK06988 412022005272 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 412022005273 active site 412022005274 substrate binding site [chemical binding]; other site 412022005275 cosubstrate binding site; other site 412022005276 catalytic site [active] 412022005277 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 412022005278 active site 412022005279 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 412022005280 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 412022005281 Ligand binding site; other site 412022005282 Putative Catalytic site; other site 412022005283 DXD motif; other site 412022005284 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 412022005285 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 412022005286 inhibitor-cofactor binding pocket; inhibition site 412022005287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022005288 catalytic residue [active] 412022005289 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 412022005290 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 412022005291 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 412022005292 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 412022005293 aminotransferase AlaT; Validated; Region: PRK09265 412022005294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022005295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022005296 homodimer interface [polypeptide binding]; other site 412022005297 catalytic residue [active] 412022005298 homoserine dehydrogenase; Provisional; Region: PRK06349 412022005299 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 412022005300 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 412022005301 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 412022005302 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 412022005303 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 412022005304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022005305 catalytic residue [active] 412022005306 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412022005307 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412022005308 dimer interface [polypeptide binding]; other site 412022005309 putative functional site; other site 412022005310 putative MPT binding site; other site 412022005311 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 412022005312 MoaE interaction surface [polypeptide binding]; other site 412022005313 MoeB interaction surface [polypeptide binding]; other site 412022005314 thiocarboxylated glycine; other site 412022005315 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 412022005316 MoaE homodimer interface [polypeptide binding]; other site 412022005317 MoaD interaction [polypeptide binding]; other site 412022005318 active site residues [active] 412022005319 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 412022005320 apolar tunnel; other site 412022005321 heme binding site [chemical binding]; other site 412022005322 dimerization interface [polypeptide binding]; other site 412022005323 Transcriptional regulator; Region: Rrf2; cl17282 412022005324 Rrf2 family protein; Region: rrf2_super; TIGR00738 412022005325 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 412022005326 Clp amino terminal domain; Region: Clp_N; pfam02861 412022005327 Clp amino terminal domain; Region: Clp_N; pfam02861 412022005328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022005329 Walker A motif; other site 412022005330 ATP binding site [chemical binding]; other site 412022005331 Walker B motif; other site 412022005332 arginine finger; other site 412022005333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022005334 Walker A motif; other site 412022005335 ATP binding site [chemical binding]; other site 412022005336 Walker B motif; other site 412022005337 arginine finger; other site 412022005338 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412022005339 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 412022005340 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 412022005341 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 412022005342 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 412022005343 DNA binding residues [nucleotide binding] 412022005344 putative dimer interface [polypeptide binding]; other site 412022005345 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 412022005346 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 412022005347 putative efflux protein, MATE family; Region: matE; TIGR00797 412022005348 cation binding site [ion binding]; other site 412022005349 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 412022005350 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 412022005351 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 412022005352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005353 putative substrate translocation pore; other site 412022005354 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022005355 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 412022005356 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 412022005357 DNA binding residues [nucleotide binding] 412022005358 transcription termination factor Rho; Provisional; Region: rho; PRK09376 412022005359 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 412022005360 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 412022005361 RNA binding site [nucleotide binding]; other site 412022005362 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 412022005363 multimer interface [polypeptide binding]; other site 412022005364 Walker A motif; other site 412022005365 ATP binding site [chemical binding]; other site 412022005366 Walker B motif; other site 412022005367 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412022005368 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022005369 catalytic residues [active] 412022005370 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 412022005371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022005372 Walker A motif; other site 412022005373 ATP binding site [chemical binding]; other site 412022005374 Walker B motif; other site 412022005375 arginine finger; other site 412022005376 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 412022005377 hypothetical protein; Validated; Region: PRK00153 412022005378 recombination protein RecR; Reviewed; Region: recR; PRK00076 412022005379 RecR protein; Region: RecR; pfam02132 412022005380 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 412022005381 putative active site [active] 412022005382 putative metal-binding site [ion binding]; other site 412022005383 tetramer interface [polypeptide binding]; other site 412022005384 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022005385 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022005386 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 412022005387 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 412022005388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022005389 S-adenosylmethionine binding site [chemical binding]; other site 412022005390 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412022005391 Peptidase family M23; Region: Peptidase_M23; pfam01551 412022005392 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 412022005393 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412022005394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022005395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022005396 DNA binding residues [nucleotide binding] 412022005397 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 412022005398 active site 412022005399 catalytic site [active] 412022005400 substrate binding site [chemical binding]; other site 412022005401 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 412022005402 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 412022005403 putative catalytic site [active] 412022005404 putative metal binding site [ion binding]; other site 412022005405 putative phosphate binding site [ion binding]; other site 412022005406 putative catalytic site [active] 412022005407 putative phosphate binding site [ion binding]; other site 412022005408 putative metal binding site [ion binding]; other site 412022005409 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 412022005410 TRAM domain; Region: TRAM; cl01282 412022005411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022005412 S-adenosylmethionine binding site [chemical binding]; other site 412022005413 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 412022005414 YccA-like proteins; Region: YccA_like; cd10433 412022005415 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 412022005416 active site 412022005417 multimer interface [polypeptide binding]; other site 412022005418 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 412022005419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022005420 FeS/SAM binding site; other site 412022005421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022005422 non-specific DNA binding site [nucleotide binding]; other site 412022005423 salt bridge; other site 412022005424 sequence-specific DNA binding site [nucleotide binding]; other site 412022005425 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 412022005426 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412022005427 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 412022005428 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412022005429 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 412022005430 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412022005431 dimer interface [polypeptide binding]; other site 412022005432 motif 1; other site 412022005433 active site 412022005434 motif 2; other site 412022005435 motif 3; other site 412022005436 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 412022005437 anticodon binding site; other site 412022005438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 412022005439 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 412022005440 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 412022005441 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 412022005442 Trp docking motif [polypeptide binding]; other site 412022005443 active site 412022005444 GTP-binding protein Der; Reviewed; Region: PRK00093 412022005445 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 412022005446 G1 box; other site 412022005447 GTP/Mg2+ binding site [chemical binding]; other site 412022005448 Switch I region; other site 412022005449 G2 box; other site 412022005450 Switch II region; other site 412022005451 G3 box; other site 412022005452 G4 box; other site 412022005453 G5 box; other site 412022005454 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 412022005455 G1 box; other site 412022005456 GTP/Mg2+ binding site [chemical binding]; other site 412022005457 Switch I region; other site 412022005458 G2 box; other site 412022005459 G3 box; other site 412022005460 Switch II region; other site 412022005461 G4 box; other site 412022005462 G5 box; other site 412022005463 bacterial Hfq-like; Region: Hfq; cd01716 412022005464 hexamer interface [polypeptide binding]; other site 412022005465 Sm1 motif; other site 412022005466 RNA binding site [nucleotide binding]; other site 412022005467 Sm2 motif; other site 412022005468 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 412022005469 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 412022005470 HflX GTPase family; Region: HflX; cd01878 412022005471 G1 box; other site 412022005472 GTP/Mg2+ binding site [chemical binding]; other site 412022005473 Switch I region; other site 412022005474 G2 box; other site 412022005475 G3 box; other site 412022005476 Switch II region; other site 412022005477 G4 box; other site 412022005478 G5 box; other site 412022005479 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 412022005480 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 412022005481 HflK protein; Region: hflK; TIGR01933 412022005482 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 412022005483 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 412022005484 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 412022005485 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412022005486 dimer interface [polypeptide binding]; other site 412022005487 motif 1; other site 412022005488 active site 412022005489 motif 2; other site 412022005490 motif 3; other site 412022005491 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 412022005492 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 412022005493 GDP-binding site [chemical binding]; other site 412022005494 ACT binding site; other site 412022005495 IMP binding site; other site 412022005496 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 412022005497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022005498 active site 412022005499 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 412022005500 potassium uptake protein; Region: kup; TIGR00794 412022005501 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 412022005502 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 412022005503 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 412022005504 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 412022005505 RNA binding site [nucleotide binding]; other site 412022005506 Protein of unknown function (DUF465); Region: DUF465; pfam04325 412022005507 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 412022005508 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 412022005509 DEAD_2; Region: DEAD_2; pfam06733 412022005510 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 412022005511 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 412022005512 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 412022005513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022005514 RNA binding surface [nucleotide binding]; other site 412022005515 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412022005516 active site 412022005517 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 412022005518 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 412022005519 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 412022005520 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 412022005521 putative acyltransferase; Provisional; Region: PRK05790 412022005522 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022005523 dimer interface [polypeptide binding]; other site 412022005524 active site 412022005525 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 412022005526 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 412022005527 NAD(P) binding site [chemical binding]; other site 412022005528 homotetramer interface [polypeptide binding]; other site 412022005529 homodimer interface [polypeptide binding]; other site 412022005530 active site 412022005531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 412022005532 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 412022005533 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 412022005534 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 412022005535 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 412022005536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022005537 FeS/SAM binding site; other site 412022005538 TRAM domain; Region: TRAM; cl01282 412022005539 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412022005540 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 412022005541 substrate binding site [chemical binding]; other site 412022005542 ATP binding site [chemical binding]; other site 412022005543 beta-ketothiolase; Provisional; Region: PRK09051 412022005544 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022005545 dimer interface [polypeptide binding]; other site 412022005546 active site 412022005547 cystathionine beta-lyase; Provisional; Region: PRK07050 412022005548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022005549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022005550 catalytic residue [active] 412022005551 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 412022005552 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 412022005553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022005554 motif II; other site 412022005555 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 412022005556 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 412022005557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022005558 Walker A/P-loop; other site 412022005559 ATP binding site [chemical binding]; other site 412022005560 Q-loop/lid; other site 412022005561 ABC transporter signature motif; other site 412022005562 Walker B; other site 412022005563 D-loop; other site 412022005564 H-loop/switch region; other site 412022005565 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 412022005566 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 412022005567 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 412022005568 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022005569 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022005570 ABC transporter; Region: ABC_tran_2; pfam12848 412022005571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022005572 Burkholderia Lethal Factor 1; Region: BPSL1549; cd12812 412022005573 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 412022005574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022005575 NAD binding site [chemical binding]; other site 412022005576 catalytic residues [active] 412022005577 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 412022005578 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 412022005579 FMN binding site [chemical binding]; other site 412022005580 substrate binding site [chemical binding]; other site 412022005581 putative catalytic residue [active] 412022005582 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 412022005583 Predicted Fe-S protein [General function prediction only]; Region: COG3313 412022005584 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 412022005585 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 412022005586 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 412022005587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412022005588 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 412022005589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022005590 Walker A/P-loop; other site 412022005591 ATP binding site [chemical binding]; other site 412022005592 Q-loop/lid; other site 412022005593 ABC transporter signature motif; other site 412022005594 Walker B; other site 412022005595 D-loop; other site 412022005596 H-loop/switch region; other site 412022005597 TOBE domain; Region: TOBE_2; pfam08402 412022005598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022005599 dimer interface [polypeptide binding]; other site 412022005600 conserved gate region; other site 412022005601 putative PBP binding loops; other site 412022005602 ABC-ATPase subunit interface; other site 412022005603 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412022005604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022005605 dimer interface [polypeptide binding]; other site 412022005606 conserved gate region; other site 412022005607 putative PBP binding loops; other site 412022005608 ABC-ATPase subunit interface; other site 412022005609 Transposase; Region: HTH_Tnp_1; pfam01527 412022005610 HTH-like domain; Region: HTH_21; pfam13276 412022005611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022005612 Integrase core domain; Region: rve; pfam00665 412022005613 Integrase core domain; Region: rve_3; pfam13683 412022005614 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 412022005615 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 412022005616 TadE-like protein; Region: TadE; pfam07811 412022005617 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 412022005618 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 412022005619 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 412022005620 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022005621 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 412022005622 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 412022005623 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 412022005624 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 412022005625 ATP binding site [chemical binding]; other site 412022005626 Walker A motif; other site 412022005627 hexamer interface [polypeptide binding]; other site 412022005628 Walker B motif; other site 412022005629 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 412022005630 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022005631 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 412022005632 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022005633 TPR repeat; Region: TPR_11; pfam13414 412022005634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022005635 binding surface 412022005636 TPR motif; other site 412022005637 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 412022005638 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 412022005639 Predicted membrane protein [Function unknown]; Region: COG4655 412022005640 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 412022005641 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 412022005642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022005643 Walker A motif; other site 412022005644 ATP binding site [chemical binding]; other site 412022005645 Walker B motif; other site 412022005646 arginine finger; other site 412022005647 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022005648 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 412022005649 bacterial Hfq-like; Region: Hfq; cd01716 412022005650 hexamer interface [polypeptide binding]; other site 412022005651 Sm1 motif; other site 412022005652 RNA binding site [nucleotide binding]; other site 412022005653 Sm2 motif; other site 412022005654 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 412022005655 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 412022005656 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 412022005657 acyl-activating enzyme (AAE) consensus motif; other site 412022005658 putative AMP binding site [chemical binding]; other site 412022005659 putative active site [active] 412022005660 putative CoA binding site [chemical binding]; other site 412022005661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022005662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022005663 putative sialic acid transporter; Region: 2A0112; TIGR00891 412022005664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005665 putative substrate translocation pore; other site 412022005666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412022005667 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412022005668 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 412022005669 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 412022005670 Sulfate transporter family; Region: Sulfate_transp; pfam00916 412022005671 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 412022005672 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 412022005673 metal binding site [ion binding]; metal-binding site 412022005674 Phosphoesterase family; Region: Phosphoesterase; pfam04185 412022005675 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022005676 dimer interface [polypeptide binding]; other site 412022005677 putative CheW interface [polypeptide binding]; other site 412022005678 Transposase domain (DUF772); Region: DUF772; pfam05598 412022005679 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022005680 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022005681 ribonuclease R; Region: RNase_R; TIGR02063 412022005682 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 412022005683 RNB domain; Region: RNB; pfam00773 412022005684 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022005685 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 412022005686 RNA binding site [nucleotide binding]; other site 412022005687 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 412022005688 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 412022005689 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412022005690 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 412022005691 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412022005692 amidase catalytic site [active] 412022005693 Zn binding residues [ion binding]; other site 412022005694 substrate binding site [chemical binding]; other site 412022005695 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 412022005696 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 412022005697 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412022005698 active site 412022005699 dimer interface [polypeptide binding]; other site 412022005700 Transcriptional regulators [Transcription]; Region: FadR; COG2186 412022005701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022005702 DNA-binding site [nucleotide binding]; DNA binding site 412022005703 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 412022005704 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 412022005705 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412022005706 HTH-like domain; Region: HTH_21; pfam13276 412022005707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022005708 Integrase core domain; Region: rve; pfam00665 412022005709 Integrase core domain; Region: rve_3; pfam13683 412022005710 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 412022005711 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 412022005712 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 412022005713 active site 412022005714 Transposase; Region: HTH_Tnp_1; pfam01527 412022005715 HTH-like domain; Region: HTH_21; pfam13276 412022005716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022005717 Integrase core domain; Region: rve; pfam00665 412022005718 Integrase core domain; Region: rve_3; pfam13683 412022005719 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 412022005720 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 412022005721 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 412022005722 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 412022005723 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 412022005724 Predicted ATPase [General function prediction only]; Region: COG1485 412022005725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022005726 Walker B; other site 412022005727 D-loop; other site 412022005728 H-loop/switch region; other site 412022005729 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 412022005730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022005731 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412022005732 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 412022005733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412022005734 E3 interaction surface; other site 412022005735 lipoyl attachment site [posttranslational modification]; other site 412022005736 e3 binding domain; Region: E3_binding; pfam02817 412022005737 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412022005738 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 412022005739 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 412022005740 TPP-binding site [chemical binding]; other site 412022005741 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 412022005742 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 412022005743 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 412022005744 G1 box; other site 412022005745 putative GEF interaction site [polypeptide binding]; other site 412022005746 GTP/Mg2+ binding site [chemical binding]; other site 412022005747 Switch I region; other site 412022005748 G2 box; other site 412022005749 G3 box; other site 412022005750 Switch II region; other site 412022005751 G4 box; other site 412022005752 G5 box; other site 412022005753 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 412022005754 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 412022005755 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412022005756 MarR family; Region: MarR_2; pfam12802 412022005757 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022005758 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 412022005759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022005760 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022005761 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022005762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005763 putative substrate translocation pore; other site 412022005764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005765 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 412022005766 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 412022005767 RNA binding site [nucleotide binding]; other site 412022005768 active site 412022005769 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 412022005770 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 412022005771 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 412022005772 translation initiation factor IF-2; Region: IF-2; TIGR00487 412022005773 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 412022005774 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 412022005775 G1 box; other site 412022005776 putative GEF interaction site [polypeptide binding]; other site 412022005777 GTP/Mg2+ binding site [chemical binding]; other site 412022005778 Switch I region; other site 412022005779 G2 box; other site 412022005780 G3 box; other site 412022005781 Switch II region; other site 412022005782 G4 box; other site 412022005783 G5 box; other site 412022005784 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 412022005785 Translation-initiation factor 2; Region: IF-2; pfam11987 412022005786 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 412022005787 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 412022005788 NusA N-terminal domain; Region: NusA_N; pfam08529 412022005789 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 412022005790 RNA binding site [nucleotide binding]; other site 412022005791 homodimer interface [polypeptide binding]; other site 412022005792 NusA-like KH domain; Region: KH_5; pfam13184 412022005793 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 412022005794 G-X-X-G motif; other site 412022005795 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 412022005796 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 412022005797 ribosome maturation protein RimP; Reviewed; Region: PRK00092 412022005798 Sm and related proteins; Region: Sm_like; cl00259 412022005799 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 412022005800 putative oligomer interface [polypeptide binding]; other site 412022005801 putative RNA binding site [nucleotide binding]; other site 412022005802 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412022005803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022005804 RNA binding surface [nucleotide binding]; other site 412022005805 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 412022005806 probable active site [active] 412022005807 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 412022005808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022005809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022005810 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 412022005811 putative dimerization interface [polypeptide binding]; other site 412022005812 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 412022005813 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412022005814 Uncharacterized conserved protein [Function unknown]; Region: COG1434 412022005815 putative active site [active] 412022005816 outer membrane protein A; Reviewed; Region: PRK10808 412022005817 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 412022005818 Transposase; Region: HTH_Tnp_1; pfam01527 412022005819 HTH-like domain; Region: HTH_21; pfam13276 412022005820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022005821 Integrase core domain; Region: rve; pfam00665 412022005822 Integrase core domain; Region: rve_3; pfam13683 412022005823 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 412022005824 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 412022005825 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 412022005826 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 412022005827 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 412022005828 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 412022005829 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412022005830 DNA binding residues [nucleotide binding] 412022005831 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412022005832 IHF dimer interface [polypeptide binding]; other site 412022005833 IHF - DNA interface [nucleotide binding]; other site 412022005834 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 412022005835 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 412022005836 putative tRNA-binding site [nucleotide binding]; other site 412022005837 B3/4 domain; Region: B3_4; pfam03483 412022005838 tRNA synthetase B5 domain; Region: B5; smart00874 412022005839 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 412022005840 dimer interface [polypeptide binding]; other site 412022005841 motif 1; other site 412022005842 motif 3; other site 412022005843 motif 2; other site 412022005844 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 412022005845 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 412022005846 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 412022005847 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 412022005848 dimer interface [polypeptide binding]; other site 412022005849 motif 1; other site 412022005850 active site 412022005851 motif 2; other site 412022005852 motif 3; other site 412022005853 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 412022005854 23S rRNA binding site [nucleotide binding]; other site 412022005855 L21 binding site [polypeptide binding]; other site 412022005856 L13 binding site [polypeptide binding]; other site 412022005857 translation initiation factor IF-3; Region: infC; TIGR00168 412022005858 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 412022005859 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 412022005860 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 412022005861 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 412022005862 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412022005863 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 412022005864 active site 412022005865 dimer interface [polypeptide binding]; other site 412022005866 motif 1; other site 412022005867 motif 2; other site 412022005868 motif 3; other site 412022005869 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 412022005870 anticodon binding site; other site 412022005871 HD domain; Region: HD_4; pfam13328 412022005872 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412022005873 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412022005874 synthetase active site [active] 412022005875 NTP binding site [chemical binding]; other site 412022005876 metal binding site [ion binding]; metal-binding site 412022005877 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412022005878 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 412022005879 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 412022005880 homotrimer interaction site [polypeptide binding]; other site 412022005881 putative active site [active] 412022005882 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022005883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412022005884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022005885 transcriptional activator TtdR; Provisional; Region: PRK09801 412022005886 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022005887 putative effector binding pocket; other site 412022005888 dimerization interface [polypeptide binding]; other site 412022005889 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 412022005890 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 412022005891 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 412022005892 short chain dehydrogenase; Provisional; Region: PRK07041 412022005893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022005894 NAD(P) binding site [chemical binding]; other site 412022005895 active site 412022005896 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 412022005897 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 412022005898 PAS domain; Region: PAS_9; pfam13426 412022005899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022005900 putative active site [active] 412022005901 heme pocket [chemical binding]; other site 412022005902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022005903 DNA binding residues [nucleotide binding] 412022005904 dimerization interface [polypeptide binding]; other site 412022005905 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 412022005906 active site 412022005907 short chain dehydrogenase; Provisional; Region: PRK06949 412022005908 classical (c) SDRs; Region: SDR_c; cd05233 412022005909 NAD(P) binding site [chemical binding]; other site 412022005910 active site 412022005911 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 412022005912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412022005913 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 412022005914 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 412022005915 Transposase; Region: HTH_Tnp_1; pfam01527 412022005916 HTH-like domain; Region: HTH_21; pfam13276 412022005917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022005918 Integrase core domain; Region: rve; pfam00665 412022005919 Integrase core domain; Region: rve_3; pfam13683 412022005920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022005921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022005922 catalytic residue [active] 412022005923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022005924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022005925 Cupin-like domain; Region: Cupin_8; pfam13621 412022005926 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 412022005927 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022005928 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022005929 trimer interface [polypeptide binding]; other site 412022005930 eyelet of channel; other site 412022005931 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022005932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022005933 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022005934 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022005935 EamA-like transporter family; Region: EamA; pfam00892 412022005936 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 412022005937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022005938 dimer interface [polypeptide binding]; other site 412022005939 putative CheW interface [polypeptide binding]; other site 412022005940 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 412022005941 AMP-binding domain protein; Validated; Region: PRK07529 412022005942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022005943 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 412022005944 acyl-activating enzyme (AAE) consensus motif; other site 412022005945 putative AMP binding site [chemical binding]; other site 412022005946 putative active site [active] 412022005947 putative CoA binding site [chemical binding]; other site 412022005948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022005949 putative substrate translocation pore; other site 412022005950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022005951 S-adenosylmethionine binding site [chemical binding]; other site 412022005952 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 412022005953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022005954 dimer interface [polypeptide binding]; other site 412022005955 conserved gate region; other site 412022005956 putative PBP binding loops; other site 412022005957 ABC-ATPase subunit interface; other site 412022005958 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 412022005959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022005960 Walker A/P-loop; other site 412022005961 ATP binding site [chemical binding]; other site 412022005962 Q-loop/lid; other site 412022005963 ABC transporter signature motif; other site 412022005964 Walker B; other site 412022005965 D-loop; other site 412022005966 H-loop/switch region; other site 412022005967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022005968 ABC-ATPase subunit interface; other site 412022005969 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 412022005970 arginine deiminase; Provisional; Region: PRK01388 412022005971 ornithine carbamoyltransferase; Validated; Region: PRK02102 412022005972 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412022005973 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412022005974 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 412022005975 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 412022005976 putative substrate binding site [chemical binding]; other site 412022005977 nucleotide binding site [chemical binding]; other site 412022005978 nucleotide binding site [chemical binding]; other site 412022005979 homodimer interface [polypeptide binding]; other site 412022005980 short chain dehydrogenase; Provisional; Region: PRK09291 412022005981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022005982 NAD(P) binding site [chemical binding]; other site 412022005983 active site 412022005984 Domain of unknown function (DUF336); Region: DUF336; pfam03928 412022005985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022005986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022005987 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 412022005988 putative effector binding pocket; other site 412022005989 putative dimerization interface [polypeptide binding]; other site 412022005990 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 412022005991 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 412022005992 C-terminal domain interface [polypeptide binding]; other site 412022005993 GSH binding site (G-site) [chemical binding]; other site 412022005994 dimer interface [polypeptide binding]; other site 412022005995 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 412022005996 dimer interface [polypeptide binding]; other site 412022005997 N-terminal domain interface [polypeptide binding]; other site 412022005998 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412022005999 MarR family; Region: MarR_2; pfam12802 412022006000 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 412022006001 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 412022006002 dimerization interface [polypeptide binding]; other site 412022006003 ligand binding site [chemical binding]; other site 412022006004 MarR family; Region: MarR_2; cl17246 412022006005 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022006006 putative cyanate transporter; Provisional; Region: cynX; PRK09705 412022006007 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 412022006008 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 412022006009 active site 412022006010 SAM binding site [chemical binding]; other site 412022006011 homodimer interface [polypeptide binding]; other site 412022006012 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 412022006013 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 412022006014 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 412022006015 active site 412022006016 putative homodimer interface [polypeptide binding]; other site 412022006017 SAM binding site [chemical binding]; other site 412022006018 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 412022006019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022006020 S-adenosylmethionine binding site [chemical binding]; other site 412022006021 precorrin-3B synthase; Region: CobG; TIGR02435 412022006022 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022006023 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022006024 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 412022006025 Precorrin-8X methylmutase; Region: CbiC; pfam02570 412022006026 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 412022006027 active site 412022006028 SAM binding site [chemical binding]; other site 412022006029 homodimer interface [polypeptide binding]; other site 412022006030 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 412022006031 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 412022006032 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 412022006033 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 412022006034 active site 412022006035 SAM binding site [chemical binding]; other site 412022006036 homodimer interface [polypeptide binding]; other site 412022006037 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 412022006038 active site 412022006039 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 412022006040 aromatic chitin/cellulose binding site residues [chemical binding]; other site 412022006041 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 412022006042 aromatic chitin/cellulose binding site residues [chemical binding]; other site 412022006043 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 412022006044 Serine hydrolase (FSH1); Region: FSH1; pfam03959 412022006045 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 412022006046 metal ion-dependent adhesion site (MIDAS); other site 412022006047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022006048 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412022006049 Walker A motif; other site 412022006050 ATP binding site [chemical binding]; other site 412022006051 Walker B motif; other site 412022006052 arginine finger; other site 412022006053 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 412022006054 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 412022006055 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 412022006056 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 412022006057 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 412022006058 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 412022006059 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 412022006060 High-affinity nickel-transport protein; Region: NicO; cl00964 412022006061 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 412022006062 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 412022006063 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 412022006064 homodimer interface [polypeptide binding]; other site 412022006065 Walker A motif; other site 412022006066 ATP binding site [chemical binding]; other site 412022006067 hydroxycobalamin binding site [chemical binding]; other site 412022006068 Walker B motif; other site 412022006069 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 412022006070 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 412022006071 catalytic triad [active] 412022006072 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 412022006073 catalytic site [active] 412022006074 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 412022006075 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022006076 N-terminal plug; other site 412022006077 ligand-binding site [chemical binding]; other site 412022006078 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 412022006079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022006080 Condensation domain; Region: Condensation; pfam00668 412022006081 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022006082 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022006083 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022006084 acyl-activating enzyme (AAE) consensus motif; other site 412022006085 AMP binding site [chemical binding]; other site 412022006086 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022006087 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022006088 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022006089 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022006090 acyl-activating enzyme (AAE) consensus motif; other site 412022006091 AMP binding site [chemical binding]; other site 412022006092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022006093 Condensation domain; Region: Condensation; pfam00668 412022006094 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022006095 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022006096 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022006097 acyl-activating enzyme (AAE) consensus motif; other site 412022006098 AMP binding site [chemical binding]; other site 412022006099 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022006100 Condensation domain; Region: Condensation; pfam00668 412022006101 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 412022006102 Condensation domain; Region: Condensation; pfam00668 412022006103 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022006104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022006105 acyl-activating enzyme (AAE) consensus motif; other site 412022006106 AMP binding site [chemical binding]; other site 412022006107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022006108 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 412022006109 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 412022006110 Walker A/P-loop; other site 412022006111 ATP binding site [chemical binding]; other site 412022006112 Q-loop/lid; other site 412022006113 ABC transporter signature motif; other site 412022006114 Walker B; other site 412022006115 D-loop; other site 412022006116 H-loop/switch region; other site 412022006117 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 412022006118 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 412022006119 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 412022006120 siderophore binding site; other site 412022006121 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 412022006122 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 412022006123 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 412022006124 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412022006125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 412022006126 dimer interface [polypeptide binding]; other site 412022006127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412022006128 ABC-ATPase subunit interface; other site 412022006129 dimer interface [polypeptide binding]; other site 412022006130 putative PBP binding regions; other site 412022006131 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412022006132 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412022006133 Walker A/P-loop; other site 412022006134 ATP binding site [chemical binding]; other site 412022006135 Q-loop/lid; other site 412022006136 ABC transporter signature motif; other site 412022006137 Walker B; other site 412022006138 D-loop; other site 412022006139 H-loop/switch region; other site 412022006140 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 412022006141 MbtH-like protein; Region: MbtH; cl01279 412022006142 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 412022006143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022006144 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 412022006145 DNA binding residues [nucleotide binding] 412022006146 short chain dehydrogenase; Provisional; Region: PRK07060 412022006147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022006148 NAD(P) binding site [chemical binding]; other site 412022006149 active site 412022006150 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 412022006151 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 412022006152 N- and C-terminal domain interface [polypeptide binding]; other site 412022006153 putative active site [active] 412022006154 MgATP binding site [chemical binding]; other site 412022006155 catalytic site [active] 412022006156 metal binding site [ion binding]; metal-binding site 412022006157 putative xylulose binding site [chemical binding]; other site 412022006158 putative homodimer interface [polypeptide binding]; other site 412022006159 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 412022006160 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412022006161 NAD(P) binding site [chemical binding]; other site 412022006162 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 412022006163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022006164 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022006165 TM-ABC transporter signature motif; other site 412022006166 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 412022006167 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412022006168 Walker A/P-loop; other site 412022006169 ATP binding site [chemical binding]; other site 412022006170 Q-loop/lid; other site 412022006171 ABC transporter signature motif; other site 412022006172 Walker B; other site 412022006173 D-loop; other site 412022006174 H-loop/switch region; other site 412022006175 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412022006176 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 412022006177 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 412022006178 putative ligand binding site [chemical binding]; other site 412022006179 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022006180 Helix-turn-helix domain; Region: HTH_18; pfam12833 412022006181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022006182 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 412022006183 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 412022006184 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412022006185 Ligand Binding Site [chemical binding]; other site 412022006186 Molecular Tunnel; other site 412022006187 HTH-like domain; Region: HTH_21; pfam13276 412022006188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006189 Integrase core domain; Region: rve; pfam00665 412022006190 Integrase core domain; Region: rve_3; pfam13683 412022006191 Transposase; Region: HTH_Tnp_1; pfam01527 412022006192 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412022006193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022006194 Walker A/P-loop; other site 412022006195 ATP binding site [chemical binding]; other site 412022006196 Q-loop/lid; other site 412022006197 ABC transporter signature motif; other site 412022006198 Walker B; other site 412022006199 D-loop; other site 412022006200 H-loop/switch region; other site 412022006201 Fimbrial protein; Region: Fimbrial; pfam00419 412022006202 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 412022006203 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 412022006204 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 412022006205 PapC C-terminal domain; Region: PapC_C; pfam13953 412022006206 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 412022006207 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022006208 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022006209 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 412022006210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022006211 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 412022006212 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412022006213 Peptidase family M23; Region: Peptidase_M23; pfam01551 412022006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006215 dimer interface [polypeptide binding]; other site 412022006216 conserved gate region; other site 412022006217 putative PBP binding loops; other site 412022006218 ABC-ATPase subunit interface; other site 412022006219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006220 dimer interface [polypeptide binding]; other site 412022006221 conserved gate region; other site 412022006222 putative PBP binding loops; other site 412022006223 ABC-ATPase subunit interface; other site 412022006224 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022006225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022006226 substrate binding pocket [chemical binding]; other site 412022006227 membrane-bound complex binding site; other site 412022006228 hinge residues; other site 412022006229 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 412022006230 TadE-like protein; Region: TadE; pfam07811 412022006231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412022006232 binding surface 412022006233 TPR motif; other site 412022006234 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 412022006235 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022006236 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 412022006237 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022006238 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 412022006239 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 412022006240 ATP binding site [chemical binding]; other site 412022006241 Walker A motif; other site 412022006242 hexamer interface [polypeptide binding]; other site 412022006243 Walker B motif; other site 412022006244 AAA domain; Region: AAA_31; pfam13614 412022006245 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 412022006246 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 412022006247 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 412022006248 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 412022006249 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022006250 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 412022006251 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412022006252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412022006253 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412022006254 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412022006255 Walker A/P-loop; other site 412022006256 ATP binding site [chemical binding]; other site 412022006257 Q-loop/lid; other site 412022006258 ABC transporter signature motif; other site 412022006259 Walker B; other site 412022006260 D-loop; other site 412022006261 H-loop/switch region; other site 412022006262 NMT1-like family; Region: NMT1_2; pfam13379 412022006263 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 412022006264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006265 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 412022006266 putative substrate translocation pore; other site 412022006267 SpoVR family protein; Provisional; Region: PRK11767 412022006268 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 412022006269 hypothetical protein; Provisional; Region: PRK05325 412022006270 PrkA family serine protein kinase; Provisional; Region: PRK15455 412022006271 AAA ATPase domain; Region: AAA_16; pfam13191 412022006272 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 412022006273 HTH-like domain; Region: HTH_21; pfam13276 412022006274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006275 Integrase core domain; Region: rve; pfam00665 412022006276 Integrase core domain; Region: rve_3; pfam13683 412022006277 Transposase; Region: HTH_Tnp_1; pfam01527 412022006278 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 412022006279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006280 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 412022006281 substrate binding site [chemical binding]; other site 412022006282 dimerization interface [polypeptide binding]; other site 412022006283 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 412022006284 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 412022006285 Walker A/P-loop; other site 412022006286 ATP binding site [chemical binding]; other site 412022006287 Q-loop/lid; other site 412022006288 ABC transporter signature motif; other site 412022006289 Walker B; other site 412022006290 D-loop; other site 412022006291 H-loop/switch region; other site 412022006292 TOBE-like domain; Region: TOBE_3; pfam12857 412022006293 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 412022006294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006295 dimer interface [polypeptide binding]; other site 412022006296 conserved gate region; other site 412022006297 putative PBP binding loops; other site 412022006298 ABC-ATPase subunit interface; other site 412022006299 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 412022006300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006301 dimer interface [polypeptide binding]; other site 412022006302 conserved gate region; other site 412022006303 putative PBP binding loops; other site 412022006304 ABC-ATPase subunit interface; other site 412022006305 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 412022006306 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022006307 substrate binding pocket [chemical binding]; other site 412022006308 membrane-bound complex binding site; other site 412022006309 LexA repressor; Validated; Region: PRK00215 412022006310 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 412022006311 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 412022006312 Catalytic site [active] 412022006313 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 412022006314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022006315 Ligand Binding Site [chemical binding]; other site 412022006316 nodulation ABC transporter NodI; Provisional; Region: PRK13537 412022006317 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 412022006318 Walker A/P-loop; other site 412022006319 ATP binding site [chemical binding]; other site 412022006320 Q-loop/lid; other site 412022006321 ABC transporter signature motif; other site 412022006322 Walker B; other site 412022006323 D-loop; other site 412022006324 H-loop/switch region; other site 412022006325 ABC-2 type transporter; Region: ABC2_membrane; cl17235 412022006326 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 412022006327 Predicted permease; Region: DUF318; cl17795 412022006328 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412022006329 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412022006330 active site 412022006331 catalytic tetrad [active] 412022006332 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412022006333 CoenzymeA binding site [chemical binding]; other site 412022006334 subunit interaction site [polypeptide binding]; other site 412022006335 PHB binding site; other site 412022006336 Predicted transcriptional regulators [Transcription]; Region: COG1733 412022006337 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 412022006338 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412022006339 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 412022006340 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 412022006341 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 412022006342 FMN binding site [chemical binding]; other site 412022006343 active site 412022006344 catalytic residues [active] 412022006345 substrate binding site [chemical binding]; other site 412022006346 HTH-like domain; Region: HTH_21; pfam13276 412022006347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006348 Integrase core domain; Region: rve; pfam00665 412022006349 Integrase core domain; Region: rve_3; pfam13683 412022006350 Transposase; Region: HTH_Tnp_1; pfam01527 412022006351 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022006352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022006353 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 412022006354 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412022006355 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412022006356 Walker A/P-loop; other site 412022006357 ATP binding site [chemical binding]; other site 412022006358 Q-loop/lid; other site 412022006359 ABC transporter signature motif; other site 412022006360 Walker B; other site 412022006361 D-loop; other site 412022006362 H-loop/switch region; other site 412022006363 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412022006364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006365 dimer interface [polypeptide binding]; other site 412022006366 conserved gate region; other site 412022006367 putative PBP binding loops; other site 412022006368 ABC-ATPase subunit interface; other site 412022006369 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 412022006370 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 412022006371 active site 412022006372 dimer interface [polypeptide binding]; other site 412022006373 non-prolyl cis peptide bond; other site 412022006374 insertion regions; other site 412022006375 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 412022006376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022006377 substrate binding site [chemical binding]; other site 412022006378 oxyanion hole (OAH) forming residues; other site 412022006379 trimer interface [polypeptide binding]; other site 412022006380 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 412022006381 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 412022006382 hypothetical protein; Provisional; Region: PRK02487 412022006383 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 412022006384 nudix motif; other site 412022006385 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 412022006386 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 412022006387 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 412022006388 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 412022006389 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 412022006390 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 412022006391 quinone interaction residues [chemical binding]; other site 412022006392 active site 412022006393 catalytic residues [active] 412022006394 FMN binding site [chemical binding]; other site 412022006395 substrate binding site [chemical binding]; other site 412022006396 cystine transporter subunit; Provisional; Region: PRK11260 412022006397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022006398 substrate binding pocket [chemical binding]; other site 412022006399 membrane-bound complex binding site; other site 412022006400 hinge residues; other site 412022006401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006402 dimer interface [polypeptide binding]; other site 412022006403 conserved gate region; other site 412022006404 putative PBP binding loops; other site 412022006405 ABC-ATPase subunit interface; other site 412022006406 Transposase; Region: HTH_Tnp_1; pfam01527 412022006407 HTH-like domain; Region: HTH_21; pfam13276 412022006408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006409 Integrase core domain; Region: rve; pfam00665 412022006410 Integrase core domain; Region: rve_3; pfam13683 412022006411 HTH-like domain; Region: HTH_21; pfam13276 412022006412 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 412022006413 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 412022006414 Tetramer interface [polypeptide binding]; other site 412022006415 active site 412022006416 FMN-binding site [chemical binding]; other site 412022006417 lysophospholipid transporter LplT; Provisional; Region: PRK11195 412022006418 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412022006419 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412022006420 putative acyl-acceptor binding pocket; other site 412022006421 FOG: CBS domain [General function prediction only]; Region: COG0517 412022006422 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 412022006423 Protein of unknown function (DUF962); Region: DUF962; cl01879 412022006424 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 412022006425 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 412022006426 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412022006427 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 412022006428 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412022006429 FAD binding domain; Region: FAD_binding_4; pfam01565 412022006430 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022006431 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412022006432 active site 412022006433 metal binding site [ion binding]; metal-binding site 412022006434 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412022006435 transcriptional regulator; Provisional; Region: PRK10632 412022006436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006437 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022006438 putative effector binding pocket; other site 412022006439 dimerization interface [polypeptide binding]; other site 412022006440 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022006441 Fusaric acid resistance protein family; Region: FUSC; pfam04632 412022006442 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 412022006443 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 412022006444 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 412022006445 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022006446 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022006447 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412022006448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022006449 dimer interface [polypeptide binding]; other site 412022006450 putative CheW interface [polypeptide binding]; other site 412022006451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022006453 putative substrate translocation pore; other site 412022006454 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 412022006455 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 412022006456 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 412022006457 Part of AAA domain; Region: AAA_19; pfam13245 412022006458 Family description; Region: UvrD_C_2; pfam13538 412022006459 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 412022006460 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 412022006461 HIGH motif; other site 412022006462 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412022006463 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 412022006464 active site 412022006465 KMSKS motif; other site 412022006466 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 412022006467 tRNA binding surface [nucleotide binding]; other site 412022006468 anticodon binding site; other site 412022006469 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 412022006470 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 412022006471 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412022006472 active site 412022006473 tetramer interface; other site 412022006474 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 412022006475 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 412022006476 CHASE2 domain; Region: CHASE2; pfam05226 412022006477 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412022006478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022006479 dimer interface [polypeptide binding]; other site 412022006480 phosphorylation site [posttranslational modification] 412022006481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022006482 ATP binding site [chemical binding]; other site 412022006483 Mg2+ binding site [ion binding]; other site 412022006484 G-X-G motif; other site 412022006485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 412022006486 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412022006487 FecR protein; Region: FecR; pfam04773 412022006488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022006489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022006490 active site 412022006491 phosphorylation site [posttranslational modification] 412022006492 intermolecular recognition site; other site 412022006493 dimerization interface [polypeptide binding]; other site 412022006494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022006495 DNA binding site [nucleotide binding] 412022006496 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412022006497 CPxP motif; other site 412022006498 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 412022006499 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412022006500 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 412022006501 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412022006502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 412022006503 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 412022006504 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022006505 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022006506 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412022006507 putative active site [active] 412022006508 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 412022006509 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 412022006510 putative ligand binding site [chemical binding]; other site 412022006511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022006512 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022006513 TM-ABC transporter signature motif; other site 412022006514 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412022006515 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412022006516 Walker A/P-loop; other site 412022006517 ATP binding site [chemical binding]; other site 412022006518 Q-loop/lid; other site 412022006519 ABC transporter signature motif; other site 412022006520 Walker B; other site 412022006521 D-loop; other site 412022006522 H-loop/switch region; other site 412022006523 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412022006524 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 412022006525 substrate binding site [chemical binding]; other site 412022006526 ATP binding site [chemical binding]; other site 412022006527 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 412022006528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 412022006529 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 412022006530 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022006531 PYR/PP interface [polypeptide binding]; other site 412022006532 dimer interface [polypeptide binding]; other site 412022006533 TPP binding site [chemical binding]; other site 412022006534 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022006535 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 412022006536 TPP-binding site [chemical binding]; other site 412022006537 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 412022006538 KduI/IolB family; Region: KduI; pfam04962 412022006539 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412022006540 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412022006541 Walker A/P-loop; other site 412022006542 ATP binding site [chemical binding]; other site 412022006543 Q-loop/lid; other site 412022006544 ABC transporter signature motif; other site 412022006545 Walker B; other site 412022006546 D-loop; other site 412022006547 H-loop/switch region; other site 412022006548 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412022006549 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412022006550 TM-ABC transporter signature motif; other site 412022006551 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412022006552 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412022006553 Walker A/P-loop; other site 412022006554 ATP binding site [chemical binding]; other site 412022006555 Q-loop/lid; other site 412022006556 ABC transporter signature motif; other site 412022006557 Walker B; other site 412022006558 D-loop; other site 412022006559 H-loop/switch region; other site 412022006560 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 412022006561 TM-ABC transporter signature motif; other site 412022006562 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 412022006563 active site 412022006564 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 412022006565 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 412022006566 putative active site [active] 412022006567 metal binding site [ion binding]; metal-binding site 412022006568 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 412022006569 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 412022006570 nudix motif; other site 412022006571 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412022006572 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022006573 HTH-like domain; Region: HTH_21; pfam13276 412022006574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006575 Integrase core domain; Region: rve; pfam00665 412022006576 Integrase core domain; Region: rve_3; pfam13683 412022006577 Transposase; Region: HTH_Tnp_1; pfam01527 412022006578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022006580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022006582 dimerization interface [polypeptide binding]; other site 412022006583 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 412022006584 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 412022006585 motif 1; other site 412022006586 active site 412022006587 motif 2; other site 412022006588 motif 3; other site 412022006589 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412022006590 DHHA1 domain; Region: DHHA1; pfam02272 412022006591 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022006592 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022006593 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 412022006594 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022006595 active site 412022006596 HIGH motif; other site 412022006597 nucleotide binding site [chemical binding]; other site 412022006598 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 412022006599 KMSKS motif; other site 412022006600 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 412022006601 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412022006602 nudix motif; other site 412022006603 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 412022006604 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 412022006605 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 412022006606 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 412022006607 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 412022006608 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 412022006609 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 412022006610 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 412022006611 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 412022006612 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 412022006613 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 412022006614 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 412022006615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022006616 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022006617 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022006618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006619 putative substrate translocation pore; other site 412022006620 Outer membrane efflux protein; Region: OEP; pfam02321 412022006621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022006622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022006623 active site 412022006624 phosphorylation site [posttranslational modification] 412022006625 intermolecular recognition site; other site 412022006626 dimerization interface [polypeptide binding]; other site 412022006627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022006628 DNA binding residues [nucleotide binding] 412022006629 dimerization interface [polypeptide binding]; other site 412022006630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022006631 dimer interface [polypeptide binding]; other site 412022006632 phosphorylation site [posttranslational modification] 412022006633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022006634 ATP binding site [chemical binding]; other site 412022006635 Mg2+ binding site [ion binding]; other site 412022006636 G-X-G motif; other site 412022006637 Response regulator receiver domain; Region: Response_reg; pfam00072 412022006638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022006639 active site 412022006640 phosphorylation site [posttranslational modification] 412022006641 intermolecular recognition site; other site 412022006642 dimerization interface [polypeptide binding]; other site 412022006643 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022006644 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022006645 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 412022006646 PapC N-terminal domain; Region: PapC_N; pfam13954 412022006647 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 412022006648 PapC C-terminal domain; Region: PapC_C; pfam13953 412022006649 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 412022006650 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 412022006651 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022006652 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022006653 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022006654 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 412022006655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006656 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 412022006657 dimerization interface [polypeptide binding]; other site 412022006658 substrate binding pocket [chemical binding]; other site 412022006659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006660 putative substrate translocation pore; other site 412022006661 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 412022006662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022006663 active site 412022006664 H-NS histone family; Region: Histone_HNS; pfam00816 412022006665 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022006666 manganese transport protein MntH; Reviewed; Region: PRK00701 412022006667 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 412022006668 Transposase; Region: HTH_Tnp_1; pfam01527 412022006669 HTH-like domain; Region: HTH_21; pfam13276 412022006670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006671 Integrase core domain; Region: rve; pfam00665 412022006672 Integrase core domain; Region: rve_3; pfam13683 412022006673 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 412022006674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 412022006675 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 412022006676 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 412022006677 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 412022006678 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 412022006679 PAAR motif; Region: PAAR_motif; pfam05488 412022006680 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 412022006681 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 412022006682 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 412022006683 Ricin-type beta-trefoil; Region: RICIN; smart00458 412022006684 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 412022006685 putative sugar binding sites [chemical binding]; other site 412022006686 Q-X-W motif; other site 412022006687 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 412022006688 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 412022006689 Galactose oxidase, central domain; Region: Kelch_3; cl02701 412022006690 Kelch motif; Region: Kelch_6; pfam13964 412022006691 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 412022006692 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 412022006693 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412022006694 Cu(I) binding site [ion binding]; other site 412022006695 H-NS histone family; Region: Histone_HNS; pfam00816 412022006696 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022006697 TPR repeat; Region: TPR_11; pfam13414 412022006698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022006699 binding surface 412022006700 TPR motif; other site 412022006701 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 412022006702 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022006703 ligand binding site [chemical binding]; other site 412022006704 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 412022006705 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 412022006706 trimer interface [polypeptide binding]; other site 412022006707 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 412022006708 trimer interface [polypeptide binding]; other site 412022006709 YadA-like C-terminal region; Region: YadA; pfam03895 412022006710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022006711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022006712 active site 412022006713 phosphorylation site [posttranslational modification] 412022006714 intermolecular recognition site; other site 412022006715 dimerization interface [polypeptide binding]; other site 412022006716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022006717 DNA binding site [nucleotide binding] 412022006718 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 412022006719 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 412022006720 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 412022006721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022006722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022006723 active site 412022006724 phosphorylation site [posttranslational modification] 412022006725 intermolecular recognition site; other site 412022006726 dimerization interface [polypeptide binding]; other site 412022006727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022006728 DNA binding site [nucleotide binding] 412022006729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022006730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022006732 dimerization interface [polypeptide binding]; other site 412022006733 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 412022006734 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 412022006735 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412022006736 Interdomain contacts; other site 412022006737 Cytokine receptor motif; other site 412022006738 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 412022006739 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 412022006740 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 412022006741 active site 412022006742 homodimer interface [polypeptide binding]; other site 412022006743 catalytic site [active] 412022006744 acceptor binding site [chemical binding]; other site 412022006745 trehalose synthase; Region: treS_nterm; TIGR02456 412022006746 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 412022006747 active site 412022006748 catalytic site [active] 412022006749 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 412022006750 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 412022006751 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 412022006752 glycogen branching enzyme; Provisional; Region: PRK05402 412022006753 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 412022006754 active site 412022006755 catalytic site [active] 412022006756 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 412022006757 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 412022006758 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 412022006759 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 412022006760 active site 412022006761 catalytic site [active] 412022006762 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 412022006763 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 412022006764 catalytic site [active] 412022006765 active site 412022006766 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 412022006767 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 412022006768 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 412022006769 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 412022006770 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 412022006771 active site 412022006772 catalytic site [active] 412022006773 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 412022006774 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 412022006775 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022006776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022006777 DNA-binding site [nucleotide binding]; DNA binding site 412022006778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022006779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022006780 homodimer interface [polypeptide binding]; other site 412022006781 catalytic residue [active] 412022006782 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 412022006783 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412022006784 DNA binding residues [nucleotide binding] 412022006785 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 412022006786 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 412022006787 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 412022006788 Leucine carboxyl methyltransferase; Region: LCM; cl01306 412022006789 PAAR motif; Region: PAAR_motif; pfam05488 412022006790 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 412022006791 HTH-like domain; Region: HTH_21; pfam13276 412022006792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006793 Integrase core domain; Region: rve; pfam00665 412022006794 Integrase core domain; Region: rve_3; pfam13683 412022006795 Transposase; Region: HTH_Tnp_1; pfam01527 412022006796 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412022006797 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 412022006798 Peptidase family M23; Region: Peptidase_M23; pfam01551 412022006799 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 412022006800 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 412022006801 active site 412022006802 acyl-activating enzyme (AAE) consensus motif; other site 412022006803 putative CoA binding site [chemical binding]; other site 412022006804 AMP binding site [chemical binding]; other site 412022006805 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 412022006806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 412022006807 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 412022006808 catalytic core [active] 412022006809 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 412022006810 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 412022006811 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 412022006812 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 412022006813 polyphosphate kinase; Provisional; Region: PRK05443 412022006814 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 412022006815 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 412022006816 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 412022006817 putative active site [active] 412022006818 catalytic site [active] 412022006819 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 412022006820 putative domain interface [polypeptide binding]; other site 412022006821 putative active site [active] 412022006822 catalytic site [active] 412022006823 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412022006824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022006825 dimer interface [polypeptide binding]; other site 412022006826 phosphorylation site [posttranslational modification] 412022006827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022006828 ATP binding site [chemical binding]; other site 412022006829 Mg2+ binding site [ion binding]; other site 412022006830 G-X-G motif; other site 412022006831 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 412022006832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022006833 active site 412022006834 phosphorylation site [posttranslational modification] 412022006835 intermolecular recognition site; other site 412022006836 dimerization interface [polypeptide binding]; other site 412022006837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022006838 DNA binding site [nucleotide binding] 412022006839 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 412022006840 PhoU domain; Region: PhoU; pfam01895 412022006841 PhoU domain; Region: PhoU; pfam01895 412022006842 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 412022006843 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 412022006844 Walker A/P-loop; other site 412022006845 ATP binding site [chemical binding]; other site 412022006846 Q-loop/lid; other site 412022006847 ABC transporter signature motif; other site 412022006848 Walker B; other site 412022006849 D-loop; other site 412022006850 H-loop/switch region; other site 412022006851 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 412022006852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006853 dimer interface [polypeptide binding]; other site 412022006854 conserved gate region; other site 412022006855 putative PBP binding loops; other site 412022006856 ABC-ATPase subunit interface; other site 412022006857 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 412022006858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022006859 dimer interface [polypeptide binding]; other site 412022006860 conserved gate region; other site 412022006861 putative PBP binding loops; other site 412022006862 ABC-ATPase subunit interface; other site 412022006863 PBP superfamily domain; Region: PBP_like_2; cl17296 412022006864 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 412022006865 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 412022006866 active site 412022006867 substrate binding site [chemical binding]; other site 412022006868 metal binding site [ion binding]; metal-binding site 412022006869 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 412022006870 dihydropteroate synthase; Region: DHPS; TIGR01496 412022006871 substrate binding pocket [chemical binding]; other site 412022006872 dimer interface [polypeptide binding]; other site 412022006873 inhibitor binding site; inhibition site 412022006874 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 412022006875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022006876 Walker A motif; other site 412022006877 ATP binding site [chemical binding]; other site 412022006878 Walker B motif; other site 412022006879 arginine finger; other site 412022006880 Peptidase family M41; Region: Peptidase_M41; pfam01434 412022006881 FtsJ-like methyltransferase; Region: FtsJ; cl17430 412022006882 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 412022006883 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 412022006884 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 412022006885 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 412022006886 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 412022006887 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412022006888 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 412022006889 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412022006890 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 412022006891 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 412022006892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412022006893 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412022006894 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 412022006895 IMP binding site; other site 412022006896 dimer interface [polypeptide binding]; other site 412022006897 interdomain contacts; other site 412022006898 partial ornithine binding site; other site 412022006899 leucine export protein LeuE; Provisional; Region: PRK10958 412022006900 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 412022006901 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 412022006902 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 412022006903 catalytic site [active] 412022006904 subunit interface [polypeptide binding]; other site 412022006905 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 412022006906 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022006907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022006910 putative substrate translocation pore; other site 412022006911 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 412022006912 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412022006913 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412022006914 catalytic residue [active] 412022006915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 412022006916 Lysin motif; Region: LysM; smart00257 412022006917 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 412022006918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022006919 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 412022006920 RNA/DNA hybrid binding site [nucleotide binding]; other site 412022006921 active site 412022006922 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 412022006923 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 412022006924 active site 412022006925 catalytic site [active] 412022006926 substrate binding site [chemical binding]; other site 412022006927 hypothetical protein; Provisional; Region: PRK02237 412022006928 proline/glycine betaine transporter; Provisional; Region: PRK10642 412022006929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022006930 putative substrate translocation pore; other site 412022006931 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 412022006932 N-terminal domain interface [polypeptide binding]; other site 412022006933 Transposase; Region: HTH_Tnp_1; pfam01527 412022006934 HTH-like domain; Region: HTH_21; pfam13276 412022006935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022006936 Integrase core domain; Region: rve; pfam00665 412022006937 Integrase core domain; Region: rve_3; pfam13683 412022006938 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412022006939 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 412022006940 GSH binding site (G-site) [chemical binding]; other site 412022006941 C-terminal domain interface [polypeptide binding]; other site 412022006942 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 412022006943 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 412022006944 putative active site [active] 412022006945 catalytic site [active] 412022006946 Acyl transferase domain; Region: Acyl_transf_1; cl08282 412022006947 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 412022006948 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 412022006949 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 412022006950 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 412022006951 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 412022006952 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 412022006953 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 412022006954 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 412022006955 Malonate transporter MadL subunit; Region: MadL; cl04273 412022006956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022006957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006958 LysR substrate binding domain; Region: LysR_substrate; pfam03466 412022006959 dimerization interface [polypeptide binding]; other site 412022006960 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 412022006961 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412022006962 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022006963 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 412022006964 active site 412022006965 substrate-binding site [chemical binding]; other site 412022006966 metal-binding site [ion binding] 412022006967 GTP binding site [chemical binding]; other site 412022006968 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412022006969 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412022006970 putative dimer interface [polypeptide binding]; other site 412022006971 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412022006972 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412022006973 putative dimer interface [polypeptide binding]; other site 412022006974 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022006975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022006976 DNA-binding site [nucleotide binding]; DNA binding site 412022006977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022006978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022006979 homodimer interface [polypeptide binding]; other site 412022006980 catalytic residue [active] 412022006981 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 412022006982 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 412022006983 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022006984 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022006985 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 412022006986 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 412022006987 short chain dehydrogenase; Provisional; Region: PRK12744 412022006988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022006989 NAD(P) binding site [chemical binding]; other site 412022006990 active site 412022006991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022006992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022006993 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 412022006994 putative effector binding pocket; other site 412022006995 putative dimerization interface [polypeptide binding]; other site 412022006996 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 412022006997 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 412022006998 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 412022006999 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 412022007000 glutaminase active site [active] 412022007001 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 412022007002 dimer interface [polypeptide binding]; other site 412022007003 active site 412022007004 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 412022007005 dimer interface [polypeptide binding]; other site 412022007006 active site 412022007007 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022007008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022007009 putative DNA binding site [nucleotide binding]; other site 412022007010 putative Zn2+ binding site [ion binding]; other site 412022007011 AsnC family; Region: AsnC_trans_reg; pfam01037 412022007012 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022007013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022007014 DNA-binding site [nucleotide binding]; DNA binding site 412022007015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022007016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007017 homodimer interface [polypeptide binding]; other site 412022007018 catalytic residue [active] 412022007019 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 412022007020 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 412022007021 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 412022007022 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 412022007023 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022007024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022007025 metal binding site [ion binding]; metal-binding site 412022007026 active site 412022007027 I-site; other site 412022007028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412022007029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412022007030 DNA binding site [nucleotide binding] 412022007031 domain linker motif; other site 412022007032 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 412022007033 putative dimerization interface [polypeptide binding]; other site 412022007034 putative ligand binding site [chemical binding]; other site 412022007035 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 412022007036 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412022007037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412022007038 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412022007039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022007040 putative PBP binding loops; other site 412022007041 ABC-ATPase subunit interface; other site 412022007042 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412022007043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022007044 Walker A/P-loop; other site 412022007045 ATP binding site [chemical binding]; other site 412022007046 Q-loop/lid; other site 412022007047 ABC transporter signature motif; other site 412022007048 Walker B; other site 412022007049 D-loop; other site 412022007050 H-loop/switch region; other site 412022007051 TOBE domain; Region: TOBE_2; pfam08402 412022007052 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 412022007053 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022007054 active site 412022007055 metal binding site [ion binding]; metal-binding site 412022007056 hexamer interface [polypeptide binding]; other site 412022007057 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022007058 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022007059 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022007061 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412022007062 EamA-like transporter family; Region: EamA; pfam00892 412022007063 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 412022007064 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 412022007065 Moco binding site; other site 412022007066 metal coordination site [ion binding]; other site 412022007067 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 412022007068 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 412022007069 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 412022007070 ThiC-associated domain; Region: ThiC-associated; pfam13667 412022007071 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 412022007072 HTH-like domain; Region: HTH_21; pfam13276 412022007073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007074 Integrase core domain; Region: rve; pfam00665 412022007075 Integrase core domain; Region: rve_3; pfam13683 412022007076 Transposase; Region: HTH_Tnp_1; pfam01527 412022007077 EamA-like transporter family; Region: EamA; pfam00892 412022007078 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412022007079 EamA-like transporter family; Region: EamA; pfam00892 412022007080 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412022007081 hypothetical protein; Provisional; Region: PRK09256 412022007082 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 412022007083 AAA domain; Region: AAA_30; pfam13604 412022007084 Family description; Region: UvrD_C_2; pfam13538 412022007085 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 412022007086 Family description; Region: UvrD_C_2; pfam13538 412022007087 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 412022007088 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 412022007089 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 412022007090 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 412022007091 Predicted membrane protein [Function unknown]; Region: COG1289 412022007092 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 412022007093 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 412022007094 putative proline-specific permease; Provisional; Region: proY; PRK10580 412022007095 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412022007096 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 412022007097 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 412022007098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022007099 dimer interface [polypeptide binding]; other site 412022007100 conserved gate region; other site 412022007101 putative PBP binding loops; other site 412022007102 ABC-ATPase subunit interface; other site 412022007103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022007104 ABC-ATPase subunit interface; other site 412022007105 putative PBP binding loops; other site 412022007106 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 412022007107 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 412022007108 Walker A/P-loop; other site 412022007109 ATP binding site [chemical binding]; other site 412022007110 Q-loop/lid; other site 412022007111 ABC transporter signature motif; other site 412022007112 Walker B; other site 412022007113 D-loop; other site 412022007114 H-loop/switch region; other site 412022007115 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022007116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022007117 putative DNA binding site [nucleotide binding]; other site 412022007118 putative Zn2+ binding site [ion binding]; other site 412022007119 AsnC family; Region: AsnC_trans_reg; pfam01037 412022007120 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 412022007121 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 412022007122 NADH(P)-binding; Region: NAD_binding_10; pfam13460 412022007123 NAD binding site [chemical binding]; other site 412022007124 putative active site [active] 412022007125 substrate binding site [chemical binding]; other site 412022007126 Predicted transcriptional regulator [Transcription]; Region: COG1959 412022007127 Transcriptional regulator; Region: Rrf2; pfam02082 412022007128 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 412022007129 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 412022007130 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022007131 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 412022007132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022007133 DNA binding residues [nucleotide binding] 412022007134 dimerization interface [polypeptide binding]; other site 412022007135 Predicted membrane protein [Function unknown]; Region: COG3235 412022007136 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 412022007137 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 412022007138 putative active site [active] 412022007139 Zn binding site [ion binding]; other site 412022007140 hypothetical protein; Validated; Region: PRK02101 412022007141 PIN domain; Region: PIN_3; pfam13470 412022007142 PIN domain; Region: PIN_3; cl17397 412022007143 methionine aminotransferase; Validated; Region: PRK09082 412022007144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022007145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007146 homodimer interface [polypeptide binding]; other site 412022007147 catalytic residue [active] 412022007148 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412022007149 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 412022007150 C-terminal domain interface [polypeptide binding]; other site 412022007151 GSH binding site (G-site) [chemical binding]; other site 412022007152 dimer interface [polypeptide binding]; other site 412022007153 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 412022007154 putative N-terminal domain interface [polypeptide binding]; other site 412022007155 putative dimer interface [polypeptide binding]; other site 412022007156 putative substrate binding pocket (H-site) [chemical binding]; other site 412022007157 enoyl-CoA hydratase; Provisional; Region: PRK07511 412022007158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022007159 substrate binding site [chemical binding]; other site 412022007160 oxyanion hole (OAH) forming residues; other site 412022007161 trimer interface [polypeptide binding]; other site 412022007162 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 412022007163 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412022007164 catalytic core [active] 412022007165 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 412022007166 putative active site [active] 412022007167 putative substrate binding site [chemical binding]; other site 412022007168 ATP binding site [chemical binding]; other site 412022007169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022007170 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 412022007171 FAD binding site [chemical binding]; other site 412022007172 substrate binding site [chemical binding]; other site 412022007173 catalytic base [active] 412022007174 Right handed beta helix region; Region: Beta_helix; pfam13229 412022007175 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 412022007176 putative active site [active] 412022007177 putative catalytic site [active] 412022007178 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 412022007179 putative active site [active] 412022007180 putative catalytic site [active] 412022007181 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 412022007182 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 412022007183 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 412022007184 active site 412022007185 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 412022007186 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 412022007187 FAD binding site [chemical binding]; other site 412022007188 substrate binding site [chemical binding]; other site 412022007189 catalytic base [active] 412022007190 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 412022007191 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 412022007192 dimer interface [polypeptide binding]; other site 412022007193 ADP-ribose binding site [chemical binding]; other site 412022007194 active site 412022007195 nudix motif; other site 412022007196 metal binding site [ion binding]; metal-binding site 412022007197 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 412022007198 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 412022007199 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412022007200 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 412022007201 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412022007202 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 412022007203 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 412022007204 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412022007205 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 412022007206 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 412022007207 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 412022007208 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 412022007209 4Fe-4S binding domain; Region: Fer4; cl02805 412022007210 4Fe-4S binding domain; Region: Fer4; pfam00037 412022007211 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 412022007212 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 412022007213 NADH dehydrogenase subunit G; Validated; Region: PRK09129 412022007214 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022007215 catalytic loop [active] 412022007216 iron binding site [ion binding]; other site 412022007217 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 412022007218 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 412022007219 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 412022007220 SLBB domain; Region: SLBB; pfam10531 412022007221 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 412022007222 NADH dehydrogenase subunit E; Validated; Region: PRK07539 412022007223 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 412022007224 putative dimer interface [polypeptide binding]; other site 412022007225 [2Fe-2S] cluster binding site [ion binding]; other site 412022007226 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 412022007227 NADH dehydrogenase subunit D; Validated; Region: PRK06075 412022007228 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 412022007229 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 412022007230 NADH dehydrogenase subunit B; Validated; Region: PRK06411 412022007231 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 412022007232 Preprotein translocase SecG subunit; Region: SecG; pfam03840 412022007233 triosephosphate isomerase; Provisional; Region: PRK14567 412022007234 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 412022007235 substrate binding site [chemical binding]; other site 412022007236 dimer interface [polypeptide binding]; other site 412022007237 catalytic triad [active] 412022007238 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 412022007239 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 412022007240 NAD(P) binding site [chemical binding]; other site 412022007241 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 412022007242 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 412022007243 RNase E interface [polypeptide binding]; other site 412022007244 trimer interface [polypeptide binding]; other site 412022007245 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 412022007246 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 412022007247 RNase E interface [polypeptide binding]; other site 412022007248 trimer interface [polypeptide binding]; other site 412022007249 active site 412022007250 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 412022007251 putative nucleic acid binding region [nucleotide binding]; other site 412022007252 G-X-X-G motif; other site 412022007253 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 412022007254 RNA binding site [nucleotide binding]; other site 412022007255 domain interface; other site 412022007256 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 412022007257 16S/18S rRNA binding site [nucleotide binding]; other site 412022007258 S13e-L30e interaction site [polypeptide binding]; other site 412022007259 25S rRNA binding site [nucleotide binding]; other site 412022007260 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 412022007261 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 412022007262 putative ligand binding site [chemical binding]; other site 412022007263 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 412022007264 active site clefts [active] 412022007265 zinc binding site [ion binding]; other site 412022007266 dimer interface [polypeptide binding]; other site 412022007267 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 412022007268 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 412022007269 Sulfate transporter family; Region: Sulfate_transp; pfam00916 412022007270 2-isopropylmalate synthase; Validated; Region: PRK00915 412022007271 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 412022007272 active site 412022007273 metal binding site [ion binding]; metal-binding site 412022007274 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 412022007275 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 412022007276 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 412022007277 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 412022007278 ketol-acid reductoisomerase; Provisional; Region: PRK05479 412022007279 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 412022007280 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 412022007281 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 412022007282 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 412022007283 putative valine binding site [chemical binding]; other site 412022007284 dimer interface [polypeptide binding]; other site 412022007285 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 412022007286 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 412022007287 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022007288 PYR/PP interface [polypeptide binding]; other site 412022007289 dimer interface [polypeptide binding]; other site 412022007290 TPP binding site [chemical binding]; other site 412022007291 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022007292 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 412022007293 TPP-binding site [chemical binding]; other site 412022007294 dimer interface [polypeptide binding]; other site 412022007295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022007296 RNA polymerase factor sigma-70; Validated; Region: PRK09047 412022007297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022007298 DNA binding residues [nucleotide binding] 412022007299 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 412022007300 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 412022007301 RDD family; Region: RDD; pfam06271 412022007302 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022007303 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 412022007304 putative active site [active] 412022007305 putative metal binding site [ion binding]; other site 412022007306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022007307 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 412022007308 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 412022007309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022007310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022007311 Bacterial transcriptional repressor; Region: TetR; pfam13972 412022007312 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 412022007313 glucose-1-dehydrogenase; Provisional; Region: PRK06947 412022007314 classical (c) SDRs; Region: SDR_c; cd05233 412022007315 NAD(P) binding site [chemical binding]; other site 412022007316 active site 412022007317 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 412022007318 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 412022007319 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022007320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022007321 putative substrate translocation pore; other site 412022007322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022007323 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022007324 amidase; Provisional; Region: PRK07042 412022007325 Amidase; Region: Amidase; cl11426 412022007326 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 412022007327 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 412022007328 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412022007329 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 412022007330 apolar tunnel; other site 412022007331 heme binding site [chemical binding]; other site 412022007332 dimerization interface [polypeptide binding]; other site 412022007333 FtsX-like permease family; Region: FtsX; pfam02687 412022007334 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 412022007335 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 412022007336 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 412022007337 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 412022007338 Domain of unknown function (DUF333); Region: DUF333; pfam03891 412022007339 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 412022007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022007341 active site 412022007342 phosphorylation site [posttranslational modification] 412022007343 intermolecular recognition site; other site 412022007344 dimerization interface [polypeptide binding]; other site 412022007345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022007346 DNA binding site [nucleotide binding] 412022007347 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 412022007348 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 412022007349 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 412022007350 Ligand Binding Site [chemical binding]; other site 412022007351 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 412022007352 GAF domain; Region: GAF_3; pfam13492 412022007353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022007354 dimer interface [polypeptide binding]; other site 412022007355 phosphorylation site [posttranslational modification] 412022007356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022007357 ATP binding site [chemical binding]; other site 412022007358 Mg2+ binding site [ion binding]; other site 412022007359 G-X-G motif; other site 412022007360 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 412022007361 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 412022007362 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412022007363 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 412022007364 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 412022007365 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 412022007366 NADP binding site [chemical binding]; other site 412022007367 dimer interface [polypeptide binding]; other site 412022007368 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 412022007369 active site 412022007370 dimer interfaces [polypeptide binding]; other site 412022007371 catalytic residues [active] 412022007372 short chain dehydrogenase; Provisional; Region: PRK08339 412022007373 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 412022007374 putative NAD(P) binding site [chemical binding]; other site 412022007375 putative active site [active] 412022007376 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022007377 active site 412022007378 hypothetical protein; Validated; Region: PRK00110 412022007379 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 412022007380 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 412022007381 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 412022007382 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 412022007383 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 412022007384 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 412022007385 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 412022007386 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 412022007387 active site 412022007388 (T/H)XGH motif; other site 412022007389 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 412022007390 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 412022007391 Maf-like protein; Region: Maf; pfam02545 412022007392 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 412022007393 active site 412022007394 dimer interface [polypeptide binding]; other site 412022007395 ribonuclease G; Provisional; Region: PRK11712 412022007396 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 412022007397 homodimer interface [polypeptide binding]; other site 412022007398 oligonucleotide binding site [chemical binding]; other site 412022007399 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 412022007400 Pectinacetylesterase; Region: PAE; pfam03283 412022007401 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 412022007402 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 412022007403 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 412022007404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022007405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022007406 DNA binding residues [nucleotide binding] 412022007407 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 412022007408 Uncharacterized conserved protein [Function unknown]; Region: COG2128 412022007409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022007410 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 412022007411 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 412022007412 putative metal binding site; other site 412022007413 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022007414 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022007415 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022007416 putative active site [active] 412022007417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022007418 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 412022007419 putative ADP-binding pocket [chemical binding]; other site 412022007420 O-Antigen ligase; Region: Wzy_C; cl04850 412022007421 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022007422 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022007423 putative active site [active] 412022007424 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 412022007425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 412022007426 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 412022007427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412022007428 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 412022007429 Walker A/P-loop; other site 412022007430 ATP binding site [chemical binding]; other site 412022007431 Q-loop/lid; other site 412022007432 ABC transporter signature motif; other site 412022007433 Walker B; other site 412022007434 D-loop; other site 412022007435 H-loop/switch region; other site 412022007436 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 412022007437 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 412022007438 putative active site [active] 412022007439 putative PHP Thumb interface [polypeptide binding]; other site 412022007440 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 412022007441 generic binding surface II; other site 412022007442 generic binding surface I; other site 412022007443 rhodanese superfamily protein; Provisional; Region: PRK05320 412022007444 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 412022007445 active site residue [active] 412022007446 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 412022007447 active site 412022007448 HIGH motif; other site 412022007449 nucleotide binding site [chemical binding]; other site 412022007450 KMSKS motif; other site 412022007451 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412022007452 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412022007453 ATP binding site [chemical binding]; other site 412022007454 Mg++ binding site [ion binding]; other site 412022007455 motif III; other site 412022007456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022007457 nucleotide binding region [chemical binding]; other site 412022007458 ATP-binding site [chemical binding]; other site 412022007459 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 412022007460 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 412022007461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022007462 ATP-grasp domain; Region: ATP-grasp; pfam02222 412022007463 META domain; Region: META; pfam03724 412022007464 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 412022007465 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412022007466 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 412022007467 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 412022007468 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 412022007469 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 412022007470 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 412022007471 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 412022007472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022007473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022007474 ferredoxin; Provisional; Region: PRK06991 412022007475 Putative Fe-S cluster; Region: FeS; pfam04060 412022007476 4Fe-4S binding domain; Region: Fer4; pfam00037 412022007477 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 412022007478 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412022007479 minor groove reading motif; other site 412022007480 helix-hairpin-helix signature motif; other site 412022007481 substrate binding pocket [chemical binding]; other site 412022007482 active site 412022007483 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 412022007484 EamA-like transporter family; Region: EamA; pfam00892 412022007485 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 412022007486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022007487 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022007488 Cytochrome c; Region: Cytochrom_C; cl11414 412022007489 Cytochrome c553 [Energy production and conversion]; Region: COG2863 412022007490 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412022007491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022007492 Walker A motif; other site 412022007493 ATP binding site [chemical binding]; other site 412022007494 Walker B motif; other site 412022007495 arginine finger; other site 412022007496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 412022007497 Benzoate membrane transport protein; Region: BenE; pfam03594 412022007498 benzoate transporter; Region: benE; TIGR00843 412022007499 transaldolase-like protein; Provisional; Region: PTZ00411 412022007500 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 412022007501 active site 412022007502 dimer interface [polypeptide binding]; other site 412022007503 catalytic residue [active] 412022007504 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 412022007505 dimer interface [polypeptide binding]; other site 412022007506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022007507 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 412022007508 Na binding site [ion binding]; other site 412022007509 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 412022007510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412022007511 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 412022007512 putative active site [active] 412022007513 Chorismate lyase; Region: Chor_lyase; cl01230 412022007514 heat shock protein 90; Provisional; Region: PRK05218 412022007515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022007516 ATP binding site [chemical binding]; other site 412022007517 Mg2+ binding site [ion binding]; other site 412022007518 G-X-G motif; other site 412022007519 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412022007520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022007521 DNA-binding site [nucleotide binding]; DNA binding site 412022007522 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022007523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007524 homodimer interface [polypeptide binding]; other site 412022007525 catalytic residue [active] 412022007526 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 412022007527 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022007528 EamA-like transporter family; Region: EamA; pfam00892 412022007529 EamA-like transporter family; Region: EamA; pfam00892 412022007530 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 412022007531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022007532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007533 homodimer interface [polypeptide binding]; other site 412022007534 catalytic residue [active] 412022007535 Transposase; Region: HTH_Tnp_1; pfam01527 412022007536 HTH-like domain; Region: HTH_21; pfam13276 412022007537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007538 Integrase core domain; Region: rve; pfam00665 412022007539 Integrase core domain; Region: rve_3; pfam13683 412022007540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412022007541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022007542 non-specific DNA binding site [nucleotide binding]; other site 412022007543 salt bridge; other site 412022007544 sequence-specific DNA binding site [nucleotide binding]; other site 412022007545 Cupin domain; Region: Cupin_2; pfam07883 412022007546 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 412022007547 intersubunit interface [polypeptide binding]; other site 412022007548 active site 412022007549 Zn2+ binding site [ion binding]; other site 412022007550 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 412022007551 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 412022007552 inhibitor site; inhibition site 412022007553 active site 412022007554 dimer interface [polypeptide binding]; other site 412022007555 catalytic residue [active] 412022007556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 412022007557 MOSC domain; Region: MOSC; pfam03473 412022007558 3-alpha domain; Region: 3-alpha; pfam03475 412022007559 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022007560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022007561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022007562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022007563 dimerization interface [polypeptide binding]; other site 412022007564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022007565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022007566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022007567 dimerization interface [polypeptide binding]; other site 412022007568 CopC domain; Region: CopC; pfam04234 412022007569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022007570 RNA binding surface [nucleotide binding]; other site 412022007571 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412022007572 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 412022007573 active site 412022007574 uracil binding [chemical binding]; other site 412022007575 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022007576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022007577 NAD(P) binding site [chemical binding]; other site 412022007578 active site 412022007579 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 412022007580 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022007581 catalytic loop [active] 412022007582 iron binding site [ion binding]; other site 412022007583 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 412022007584 FAD binding pocket [chemical binding]; other site 412022007585 FAD binding motif [chemical binding]; other site 412022007586 phosphate binding motif [ion binding]; other site 412022007587 beta-alpha-beta structure motif; other site 412022007588 NAD binding pocket [chemical binding]; other site 412022007589 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 412022007590 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022007591 inhibitor-cofactor binding pocket; inhibition site 412022007592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007593 catalytic residue [active] 412022007594 putative acetyltransferase; Provisional; Region: PRK03624 412022007595 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412022007596 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 412022007597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412022007598 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412022007599 Walker A/P-loop; other site 412022007600 ATP binding site [chemical binding]; other site 412022007601 Q-loop/lid; other site 412022007602 ABC transporter signature motif; other site 412022007603 Walker B; other site 412022007604 D-loop; other site 412022007605 H-loop/switch region; other site 412022007606 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412022007607 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412022007608 Walker A/P-loop; other site 412022007609 ATP binding site [chemical binding]; other site 412022007610 Q-loop/lid; other site 412022007611 ABC transporter signature motif; other site 412022007612 Walker B; other site 412022007613 D-loop; other site 412022007614 H-loop/switch region; other site 412022007615 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412022007616 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412022007617 TM-ABC transporter signature motif; other site 412022007618 Transposase; Region: HTH_Tnp_1; pfam01527 412022007619 HTH-like domain; Region: HTH_21; pfam13276 412022007620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007621 Integrase core domain; Region: rve; pfam00665 412022007622 Integrase core domain; Region: rve_3; pfam13683 412022007623 fumarate hydratase; Reviewed; Region: fumC; PRK00485 412022007624 Class II fumarases; Region: Fumarase_classII; cd01362 412022007625 active site 412022007626 tetramer interface [polypeptide binding]; other site 412022007627 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 412022007628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022007629 dimerization interface [polypeptide binding]; other site 412022007630 putative DNA binding site [nucleotide binding]; other site 412022007631 putative Zn2+ binding site [ion binding]; other site 412022007632 FecR protein; Region: FecR; pfam04773 412022007633 Transposase domain (DUF772); Region: DUF772; pfam05598 412022007634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022007635 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022007636 thymidylate synthase; Provisional; Region: thyA; PRK13821 412022007637 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 412022007638 dimerization interface [polypeptide binding]; other site 412022007639 active site 412022007640 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022007641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022007642 Walker A motif; other site 412022007643 ATP binding site [chemical binding]; other site 412022007644 Walker B motif; other site 412022007645 arginine finger; other site 412022007646 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022007647 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022007648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022007649 Walker A motif; other site 412022007650 ATP binding site [chemical binding]; other site 412022007651 Walker B motif; other site 412022007652 arginine finger; other site 412022007653 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 412022007654 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 412022007655 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 412022007656 folate binding site [chemical binding]; other site 412022007657 NADP+ binding site [chemical binding]; other site 412022007658 Transposase domain (DUF772); Region: DUF772; pfam05598 412022007659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022007660 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022007661 peptidase PmbA; Provisional; Region: PRK11040 412022007662 hypothetical protein; Provisional; Region: PRK05255 412022007663 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 412022007664 MPT binding site; other site 412022007665 trimer interface [polypeptide binding]; other site 412022007666 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 412022007667 catalytic site [active] 412022007668 putative active site [active] 412022007669 putative substrate binding site [chemical binding]; other site 412022007670 dimer interface [polypeptide binding]; other site 412022007671 Peptidase family M48; Region: Peptidase_M48; pfam01435 412022007672 GTPase RsgA; Reviewed; Region: PRK00098 412022007673 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 412022007674 RNA binding site [nucleotide binding]; other site 412022007675 homodimer interface [polypeptide binding]; other site 412022007676 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 412022007677 GTPase/Zn-binding domain interface [polypeptide binding]; other site 412022007678 GTP/Mg2+ binding site [chemical binding]; other site 412022007679 G4 box; other site 412022007680 G5 box; other site 412022007681 G1 box; other site 412022007682 Switch I region; other site 412022007683 G2 box; other site 412022007684 G3 box; other site 412022007685 Switch II region; other site 412022007686 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 412022007687 CobD/CbiB family protein; Provisional; Region: PRK07630 412022007688 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 412022007689 putative active site [active] 412022007690 putative CoA binding site [chemical binding]; other site 412022007691 nudix motif; other site 412022007692 metal binding site [ion binding]; metal-binding site 412022007693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022007694 Coenzyme A binding pocket [chemical binding]; other site 412022007695 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 412022007696 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 412022007697 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 412022007698 RimM N-terminal domain; Region: RimM; pfam01782 412022007699 PRC-barrel domain; Region: PRC; pfam05239 412022007700 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 412022007701 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 412022007702 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 412022007703 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 412022007704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022007705 FeS/SAM binding site; other site 412022007706 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 412022007707 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 412022007708 AsnC family; Region: AsnC_trans_reg; pfam01037 412022007709 HTH-like domain; Region: HTH_21; pfam13276 412022007710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007711 Integrase core domain; Region: rve; pfam00665 412022007712 Integrase core domain; Region: rve_3; pfam13683 412022007713 Transposase; Region: HTH_Tnp_1; pfam01527 412022007714 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 412022007715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022007716 hydroxyglutarate oxidase; Provisional; Region: PRK11728 412022007717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022007718 active site 412022007719 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 412022007720 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 412022007721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022007722 active site 412022007723 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 412022007724 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 412022007725 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 412022007726 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 412022007727 Ligand binding site [chemical binding]; other site 412022007728 Electron transfer flavoprotein domain; Region: ETF; pfam01012 412022007729 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412022007730 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412022007731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022007732 dimer interface [polypeptide binding]; other site 412022007733 conserved gate region; other site 412022007734 ABC-ATPase subunit interface; other site 412022007735 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 412022007736 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 412022007737 Walker A/P-loop; other site 412022007738 ATP binding site [chemical binding]; other site 412022007739 Q-loop/lid; other site 412022007740 ABC transporter signature motif; other site 412022007741 Walker B; other site 412022007742 D-loop; other site 412022007743 H-loop/switch region; other site 412022007744 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 412022007745 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 412022007746 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412022007747 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 412022007748 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 412022007749 putative active site [active] 412022007750 Zn binding site [ion binding]; other site 412022007751 Transglycosylase SLT domain; Region: SLT_2; pfam13406 412022007752 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412022007753 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412022007754 catalytic residue [active] 412022007755 cysteine synthase B; Region: cysM; TIGR01138 412022007756 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412022007757 dimer interface [polypeptide binding]; other site 412022007758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007759 catalytic residue [active] 412022007760 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 412022007761 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 412022007762 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 412022007763 NADP binding site [chemical binding]; other site 412022007764 homopentamer interface [polypeptide binding]; other site 412022007765 substrate binding site [chemical binding]; other site 412022007766 active site 412022007767 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 412022007768 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412022007769 putative ribose interaction site [chemical binding]; other site 412022007770 putative ADP binding site [chemical binding]; other site 412022007771 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 412022007772 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 412022007773 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 412022007774 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 412022007775 tetratricopeptide repeat protein; Provisional; Region: PRK11788 412022007776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022007777 binding surface 412022007778 TPR motif; other site 412022007779 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 412022007780 Transposase domain (DUF772); Region: DUF772; pfam05598 412022007781 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022007782 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022007783 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412022007784 IHF dimer interface [polypeptide binding]; other site 412022007785 IHF - DNA interface [nucleotide binding]; other site 412022007786 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 412022007787 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 412022007788 RNA binding site [nucleotide binding]; other site 412022007789 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 412022007790 RNA binding site [nucleotide binding]; other site 412022007791 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 412022007792 RNA binding site [nucleotide binding]; other site 412022007793 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 412022007794 RNA binding site [nucleotide binding]; other site 412022007795 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 412022007796 RNA binding site [nucleotide binding]; other site 412022007797 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 412022007798 RNA binding site [nucleotide binding]; other site 412022007799 cytidylate kinase; Provisional; Region: cmk; PRK00023 412022007800 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 412022007801 CMP-binding site; other site 412022007802 The sites determining sugar specificity; other site 412022007803 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 412022007804 prephenate dehydrogenase; Validated; Region: PRK08507 412022007805 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 412022007806 hinge; other site 412022007807 active site 412022007808 Chorismate mutase type II; Region: CM_2; smart00830 412022007809 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 412022007810 Prephenate dehydratase; Region: PDT; pfam00800 412022007811 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 412022007812 putative L-Phe binding site [chemical binding]; other site 412022007813 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 412022007814 homodimer interface [polypeptide binding]; other site 412022007815 substrate-cofactor binding pocket; other site 412022007816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022007817 catalytic residue [active] 412022007818 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 412022007819 DNA gyrase subunit A; Validated; Region: PRK05560 412022007820 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412022007821 CAP-like domain; other site 412022007822 active site 412022007823 primary dimer interface [polypeptide binding]; other site 412022007824 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412022007825 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412022007826 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412022007827 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412022007828 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412022007829 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412022007830 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022007831 ligand binding site [chemical binding]; other site 412022007832 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 412022007833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022007834 S-adenosylmethionine binding site [chemical binding]; other site 412022007835 phosphoglycolate phosphatase; Provisional; Region: PRK13226 412022007836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022007837 motif II; other site 412022007838 Transposase; Region: HTH_Tnp_1; pfam01527 412022007839 HTH-like domain; Region: HTH_21; pfam13276 412022007840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007841 Integrase core domain; Region: rve; pfam00665 412022007842 Integrase core domain; Region: rve_3; pfam13683 412022007843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022007844 S-adenosylmethionine binding site [chemical binding]; other site 412022007845 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 412022007846 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 412022007847 PBP superfamily domain; Region: PBP_like; pfam12727 412022007848 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 412022007849 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 412022007850 putative dimer interface [polypeptide binding]; other site 412022007851 [2Fe-2S] cluster binding site [ion binding]; other site 412022007852 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 412022007853 putative dimer interface [polypeptide binding]; other site 412022007854 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 412022007855 SLBB domain; Region: SLBB; pfam10531 412022007856 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 412022007857 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 412022007858 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022007859 catalytic loop [active] 412022007860 iron binding site [ion binding]; other site 412022007861 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 412022007862 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 412022007863 [4Fe-4S] binding site [ion binding]; other site 412022007864 molybdopterin cofactor binding site; other site 412022007865 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 412022007866 molybdopterin cofactor binding site; other site 412022007867 hypothetical protein; Provisional; Region: PRK06184 412022007868 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412022007869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022007870 binding surface 412022007871 TPR motif; other site 412022007872 TPR repeat; Region: TPR_11; pfam13414 412022007873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022007874 binding surface 412022007875 TPR motif; other site 412022007876 TPR repeat; Region: TPR_11; pfam13414 412022007877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022007878 TPR repeat; Region: TPR_11; pfam13414 412022007879 TPR motif; other site 412022007880 binding surface 412022007881 TPR repeat; Region: TPR_11; pfam13414 412022007882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022007883 binding surface 412022007884 TPR motif; other site 412022007885 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022007886 citrate-proton symporter; Provisional; Region: PRK15075 412022007887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022007888 putative substrate translocation pore; other site 412022007889 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 412022007890 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 412022007891 catalytic triad [active] 412022007892 amidase; Provisional; Region: PRK07056 412022007893 Amidase; Region: Amidase; cl11426 412022007894 disulfide bond formation protein B; Provisional; Region: PRK02110 412022007895 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 412022007896 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 412022007897 XdhC Rossmann domain; Region: XdhC_C; pfam13478 412022007898 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 412022007899 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 412022007900 active site 412022007901 purine riboside binding site [chemical binding]; other site 412022007902 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 412022007903 guanine deaminase; Provisional; Region: PRK09228 412022007904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022007905 active site 412022007906 Predicted membrane protein [Function unknown]; Region: COG2119 412022007907 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 412022007908 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 412022007909 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 412022007910 aminopeptidase N; Provisional; Region: pepN; PRK14015 412022007911 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 412022007912 active site 412022007913 Zn binding site [ion binding]; other site 412022007914 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 412022007915 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 412022007916 THF binding site; other site 412022007917 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 412022007918 substrate binding site [chemical binding]; other site 412022007919 THF binding site; other site 412022007920 zinc-binding site [ion binding]; other site 412022007921 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 412022007922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022007923 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 412022007924 putative dimerization interface [polypeptide binding]; other site 412022007925 fructose-1,6-bisphosphatase family protein; Region: PLN02628 412022007926 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 412022007927 AMP binding site [chemical binding]; other site 412022007928 metal binding site [ion binding]; metal-binding site 412022007929 active site 412022007930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022007931 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022007932 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412022007933 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022007934 BNR repeat-like domain; Region: BNR_2; pfam13088 412022007935 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 412022007936 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022007937 N-terminal plug; other site 412022007938 ligand-binding site [chemical binding]; other site 412022007939 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 412022007940 chorismate mutase; Provisional; Region: PRK09269 412022007941 Chorismate mutase type II; Region: CM_2; cl00693 412022007942 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 412022007943 Transposase; Region: HTH_Tnp_1; pfam01527 412022007944 HTH-like domain; Region: HTH_21; pfam13276 412022007945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007946 Integrase core domain; Region: rve; pfam00665 412022007947 Integrase core domain; Region: rve_3; pfam13683 412022007948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412022007949 Transposase; Region: HTH_Tnp_1; pfam01527 412022007950 HTH-like domain; Region: HTH_21; pfam13276 412022007951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022007952 Integrase core domain; Region: rve; pfam00665 412022007953 Integrase core domain; Region: rve_3; pfam13683 412022007954 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 412022007955 pseudouridine synthase; Region: TIGR00093 412022007956 active site 412022007957 isocitrate dehydrogenase; Validated; Region: PRK07362 412022007958 isocitrate dehydrogenase; Reviewed; Region: PRK07006 412022007959 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 412022007960 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 412022007961 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 412022007962 Transposase domain (DUF772); Region: DUF772; pfam05598 412022007963 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022007964 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022007965 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 412022007966 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 412022007967 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412022007968 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 412022007969 hypothetical protein; Reviewed; Region: PRK00024 412022007970 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 412022007971 MPN+ (JAMM) motif; other site 412022007972 Zinc-binding site [ion binding]; other site 412022007973 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 412022007974 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 412022007975 L-aspartate oxidase; Provisional; Region: PRK09077 412022007976 L-aspartate oxidase; Provisional; Region: PRK06175 412022007977 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412022007978 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 412022007979 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 412022007980 dimerization interface [polypeptide binding]; other site 412022007981 active site 412022007982 quinolinate synthetase; Provisional; Region: PRK09375 412022007983 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 412022007984 Fatty acid desaturase; Region: FA_desaturase; pfam00487 412022007985 Di-iron ligands [ion binding]; other site 412022007986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022007987 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 412022007988 Mechanosensitive ion channel; Region: MS_channel; pfam00924 412022007989 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 412022007990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022007991 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 412022007992 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 412022007993 active site 412022007994 substrate binding site [chemical binding]; other site 412022007995 cosubstrate binding site; other site 412022007996 catalytic site [active] 412022007997 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 412022007998 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 412022007999 active site 412022008000 Riboflavin kinase; Region: Flavokinase; smart00904 412022008001 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 412022008002 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022008003 active site 412022008004 HIGH motif; other site 412022008005 nucleotide binding site [chemical binding]; other site 412022008006 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412022008007 active site 412022008008 KMSKS motif; other site 412022008009 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 412022008010 tRNA binding surface [nucleotide binding]; other site 412022008011 anticodon binding site; other site 412022008012 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412022008013 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 412022008014 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 412022008015 Flavoprotein; Region: Flavoprotein; pfam02441 412022008016 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 412022008017 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 412022008018 trimer interface [polypeptide binding]; other site 412022008019 active site 412022008020 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 412022008021 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022008022 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022008023 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022008024 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 412022008025 HTH-like domain; Region: HTH_21; pfam13276 412022008026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022008027 Integrase core domain; Region: rve; pfam00665 412022008028 Integrase core domain; Region: rve_3; pfam13683 412022008029 Transposase; Region: HTH_Tnp_1; pfam01527 412022008030 superoxide dismutase; Provisional; Region: PRK10543 412022008031 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 412022008032 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 412022008033 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 412022008034 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 412022008035 generic binding surface II; other site 412022008036 generic binding surface I; other site 412022008037 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 412022008038 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 412022008039 Uncharacterized conserved protein [Function unknown]; Region: COG2835 412022008040 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 412022008041 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 412022008042 Ligand binding site; other site 412022008043 oligomer interface; other site 412022008044 adenylate kinase; Reviewed; Region: adk; PRK00279 412022008045 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 412022008046 AMP-binding site [chemical binding]; other site 412022008047 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 412022008048 Transposase domain (DUF772); Region: DUF772; pfam05598 412022008049 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022008050 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022008051 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412022008052 DNA-binding site [nucleotide binding]; DNA binding site 412022008053 RNA-binding motif; other site 412022008054 Uncharacterized conserved protein [Function unknown]; Region: COG2127 412022008055 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 412022008056 Clp amino terminal domain; Region: Clp_N; pfam02861 412022008057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022008058 Walker A motif; other site 412022008059 ATP binding site [chemical binding]; other site 412022008060 Walker B motif; other site 412022008061 arginine finger; other site 412022008062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022008063 Walker A motif; other site 412022008064 ATP binding site [chemical binding]; other site 412022008065 Walker B motif; other site 412022008066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412022008067 HTH-like domain; Region: HTH_21; pfam13276 412022008068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022008069 Integrase core domain; Region: rve; pfam00665 412022008070 Integrase core domain; Region: rve_3; pfam13683 412022008071 Transposase; Region: HTH_Tnp_1; pfam01527 412022008072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022008073 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 412022008074 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022008075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022008076 catalytic residue [active] 412022008077 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 412022008078 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 412022008079 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 412022008080 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 412022008081 active site 412022008082 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 412022008083 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 412022008084 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412022008085 Methyltransferase domain; Region: Methyltransf_12; pfam08242 412022008086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022008087 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 412022008088 Enoylreductase; Region: PKS_ER; smart00829 412022008089 NAD(P) binding site [chemical binding]; other site 412022008090 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 412022008091 KR domain; Region: KR; pfam08659 412022008092 putative NADP binding site [chemical binding]; other site 412022008093 active site 412022008094 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 412022008095 Sulfatase; Region: Sulfatase; pfam00884 412022008096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022008097 NAD(P) binding site [chemical binding]; other site 412022008098 active site 412022008099 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 412022008100 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 412022008101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022008102 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 412022008103 active site 412022008104 motif I; other site 412022008105 motif II; other site 412022008106 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 412022008107 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 412022008108 Substrate binding site; other site 412022008109 Mg++ binding site; other site 412022008110 metal-binding site 412022008111 Mg++ binding site; other site 412022008112 metal-binding site 412022008113 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022008114 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 412022008115 dimer interface [polypeptide binding]; other site 412022008116 active site 412022008117 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 412022008118 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 412022008119 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 412022008120 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 412022008121 NADP-binding site; other site 412022008122 homotetramer interface [polypeptide binding]; other site 412022008123 substrate binding site [chemical binding]; other site 412022008124 homodimer interface [polypeptide binding]; other site 412022008125 active site 412022008126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022008127 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022008128 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 412022008129 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 412022008130 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 412022008131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022008132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412022008133 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 412022008134 Walker A/P-loop; other site 412022008135 ATP binding site [chemical binding]; other site 412022008136 Q-loop/lid; other site 412022008137 ABC transporter signature motif; other site 412022008138 Walker B; other site 412022008139 D-loop; other site 412022008140 H-loop/switch region; other site 412022008141 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 412022008142 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 412022008143 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 412022008144 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 412022008145 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 412022008146 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 412022008147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022008148 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 412022008149 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 412022008150 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 412022008151 Substrate binding site; other site 412022008152 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 412022008153 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 412022008154 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 412022008155 putative active site [active] 412022008156 putative dimer interface [polypeptide binding]; other site 412022008157 mechanosensitive channel MscS; Provisional; Region: PRK10334 412022008158 Mechanosensitive ion channel; Region: MS_channel; pfam00924 412022008159 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 412022008160 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412022008161 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 412022008162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022008163 ATP binding site [chemical binding]; other site 412022008164 Mg2+ binding site [ion binding]; other site 412022008165 G-X-G motif; other site 412022008166 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 412022008167 ATP binding site [chemical binding]; other site 412022008168 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 412022008169 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 412022008170 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 412022008171 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 412022008172 SnoaL-like domain; Region: SnoaL_3; pfam13474 412022008173 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 412022008174 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 412022008175 dimerization interface [polypeptide binding]; other site 412022008176 putative ATP binding site [chemical binding]; other site 412022008177 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 412022008178 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 412022008179 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 412022008180 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 412022008181 poly(A) polymerase; Region: pcnB; TIGR01942 412022008182 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412022008183 active site 412022008184 NTP binding site [chemical binding]; other site 412022008185 metal binding triad [ion binding]; metal-binding site 412022008186 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412022008187 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 412022008188 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 412022008189 catalytic center binding site [active] 412022008190 ATP binding site [chemical binding]; other site 412022008191 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 412022008192 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 412022008193 Substrate-binding site [chemical binding]; other site 412022008194 Substrate specificity [chemical binding]; other site 412022008195 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 412022008196 oligomerization interface [polypeptide binding]; other site 412022008197 active site 412022008198 metal binding site [ion binding]; metal-binding site 412022008199 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 412022008200 chorismate binding enzyme; Region: Chorismate_bind; cl10555 412022008201 hypothetical protein; Provisional; Region: PRK07546 412022008202 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412022008203 homodimer interface [polypeptide binding]; other site 412022008204 substrate-cofactor binding pocket; other site 412022008205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022008206 catalytic residue [active] 412022008207 chaperone protein DnaJ; Provisional; Region: PRK10767 412022008208 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412022008209 HSP70 interaction site [polypeptide binding]; other site 412022008210 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 412022008211 Zn binding sites [ion binding]; other site 412022008212 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 412022008213 dimer interface [polypeptide binding]; other site 412022008214 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 412022008215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412022008216 nucleotide binding site [chemical binding]; other site 412022008217 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412022008218 GrpE; Region: GrpE; pfam01025 412022008219 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 412022008220 dimer interface [polypeptide binding]; other site 412022008221 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 412022008222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022008223 RNA binding surface [nucleotide binding]; other site 412022008224 ferrochelatase; Reviewed; Region: hemH; PRK00035 412022008225 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 412022008226 C-terminal domain interface [polypeptide binding]; other site 412022008227 active site 412022008228 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 412022008229 active site 412022008230 N-terminal domain interface [polypeptide binding]; other site 412022008231 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 412022008232 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 412022008233 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 412022008234 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 412022008235 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 412022008236 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 412022008237 Walker A/P-loop; other site 412022008238 ATP binding site [chemical binding]; other site 412022008239 Q-loop/lid; other site 412022008240 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 412022008241 ABC transporter signature motif; other site 412022008242 Walker B; other site 412022008243 D-loop; other site 412022008244 H-loop/switch region; other site 412022008245 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 412022008246 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 412022008247 metal binding triad; other site 412022008248 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 412022008249 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 412022008250 metal binding triad; other site 412022008251 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 412022008252 TIGR02099 family protein; Region: TIGR02099 412022008253 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 412022008254 nitrilase; Region: PLN02798 412022008255 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 412022008256 putative active site [active] 412022008257 catalytic triad [active] 412022008258 dimer interface [polypeptide binding]; other site 412022008259 protease TldD; Provisional; Region: tldD; PRK10735 412022008260 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 412022008261 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412022008262 Transposase domain (DUF772); Region: DUF772; pfam05598 412022008263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022008264 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022008265 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 412022008266 23S rRNA interface [nucleotide binding]; other site 412022008267 L3 interface [polypeptide binding]; other site 412022008268 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 412022008269 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 412022008270 Cupin; Region: Cupin_6; pfam12852 412022008271 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022008272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022008273 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 412022008274 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 412022008275 C-terminal domain interface [polypeptide binding]; other site 412022008276 GSH binding site (G-site) [chemical binding]; other site 412022008277 dimer interface [polypeptide binding]; other site 412022008278 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 412022008279 N-terminal domain interface [polypeptide binding]; other site 412022008280 dimer interface [polypeptide binding]; other site 412022008281 substrate binding pocket (H-site) [chemical binding]; other site 412022008282 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 412022008283 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 412022008284 C-terminal domain interface [polypeptide binding]; other site 412022008285 GSH binding site (G-site) [chemical binding]; other site 412022008286 dimer interface [polypeptide binding]; other site 412022008287 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 412022008288 N-terminal domain interface [polypeptide binding]; other site 412022008289 putative dimer interface [polypeptide binding]; other site 412022008290 active site 412022008291 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 412022008292 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 412022008293 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 412022008294 active site 412022008295 HIGH motif; other site 412022008296 dimer interface [polypeptide binding]; other site 412022008297 KMSKS motif; other site 412022008298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022008299 RNA binding surface [nucleotide binding]; other site 412022008300 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 412022008301 putative active site [active] 412022008302 dimerization interface [polypeptide binding]; other site 412022008303 putative tRNAtyr binding site [nucleotide binding]; other site 412022008304 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412022008305 catalytic core [active] 412022008306 Putative ParB-like nuclease; Region: ParBc_2; cl17538 412022008307 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 412022008308 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 412022008309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022008310 Walker A motif; other site 412022008311 ATP binding site [chemical binding]; other site 412022008312 Walker B motif; other site 412022008313 arginine finger; other site 412022008314 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 412022008315 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 412022008316 RuvA N terminal domain; Region: RuvA_N; pfam01330 412022008317 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 412022008318 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 412022008319 active site 412022008320 putative DNA-binding cleft [nucleotide binding]; other site 412022008321 dimer interface [polypeptide binding]; other site 412022008322 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 412022008323 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 412022008324 purine monophosphate binding site [chemical binding]; other site 412022008325 dimer interface [polypeptide binding]; other site 412022008326 putative catalytic residues [active] 412022008327 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 412022008328 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 412022008329 DNA-binding protein Fis; Provisional; Region: PRK01905 412022008330 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 412022008331 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 412022008332 FMN binding site [chemical binding]; other site 412022008333 active site 412022008334 catalytic residues [active] 412022008335 substrate binding site [chemical binding]; other site 412022008336 hypothetical protein; Provisional; Region: PRK06996 412022008337 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412022008338 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 412022008339 proline aminopeptidase P II; Provisional; Region: PRK10879 412022008340 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 412022008341 active site 412022008342 putative glutathione S-transferase; Provisional; Region: PRK10357 412022008343 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 412022008344 putative C-terminal domain interface [polypeptide binding]; other site 412022008345 putative GSH binding site (G-site) [chemical binding]; other site 412022008346 putative dimer interface [polypeptide binding]; other site 412022008347 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 412022008348 dimer interface [polypeptide binding]; other site 412022008349 N-terminal domain interface [polypeptide binding]; other site 412022008350 putative substrate binding pocket (H-site) [chemical binding]; other site 412022008351 Transposase domain (DUF772); Region: DUF772; pfam05598 412022008352 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022008353 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022008354 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 412022008355 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 412022008356 active site 412022008357 FMN binding site [chemical binding]; other site 412022008358 substrate binding site [chemical binding]; other site 412022008359 3Fe-4S cluster binding site [ion binding]; other site 412022008360 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 412022008361 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 412022008362 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 412022008363 nudix motif; other site 412022008364 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 412022008365 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 412022008366 ligand binding site [chemical binding]; other site 412022008367 homodimer interface [polypeptide binding]; other site 412022008368 NAD(P) binding site [chemical binding]; other site 412022008369 trimer interface B [polypeptide binding]; other site 412022008370 trimer interface A [polypeptide binding]; other site 412022008371 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 412022008372 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 412022008373 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 412022008374 Predicted transcriptional regulator [Transcription]; Region: COG2378 412022008375 HTH domain; Region: HTH_11; pfam08279 412022008376 WYL domain; Region: WYL; pfam13280 412022008377 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 412022008378 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 412022008379 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 412022008380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412022008381 Site-specific recombinase; Region: SpecificRecomb; pfam10136 412022008382 Protein of unknown function (DUF330); Region: DUF330; pfam03886 412022008383 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 412022008384 mce related protein; Region: MCE; pfam02470 412022008385 mce related protein; Region: MCE; pfam02470 412022008386 Paraquat-inducible protein A; Region: PqiA; pfam04403 412022008387 Paraquat-inducible protein A; Region: PqiA; pfam04403 412022008388 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 412022008389 YceI-like domain; Region: YceI; smart00867 412022008390 Uncharacterized conserved protein [Function unknown]; Region: COG2353 412022008391 citrate-proton symporter; Provisional; Region: PRK15075 412022008392 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 412022008393 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412022008394 Protein export membrane protein; Region: SecD_SecF; pfam02355 412022008395 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 412022008396 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 412022008397 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412022008398 Protein export membrane protein; Region: SecD_SecF; cl14618 412022008399 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 412022008400 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 412022008401 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 412022008402 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 412022008403 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 412022008404 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 412022008405 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 412022008406 generic binding surface II; other site 412022008407 ssDNA binding site; other site 412022008408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022008409 ATP binding site [chemical binding]; other site 412022008410 putative Mg++ binding site [ion binding]; other site 412022008411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022008412 nucleotide binding region [chemical binding]; other site 412022008413 ATP-binding site [chemical binding]; other site 412022008414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022008415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022008416 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 412022008417 dimerization interface [polypeptide binding]; other site 412022008418 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 412022008419 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 412022008420 dimer interface [polypeptide binding]; other site 412022008421 active site 412022008422 heme binding site [chemical binding]; other site 412022008423 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 412022008424 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 412022008425 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 412022008426 dimerization interface [polypeptide binding]; other site 412022008427 DPS ferroxidase diiron center [ion binding]; other site 412022008428 ion pore; other site 412022008429 Predicted transcriptional regulators [Transcription]; Region: COG1733 412022008430 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 412022008431 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 412022008432 UbiA prenyltransferase family; Region: UbiA; pfam01040 412022008433 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 412022008434 active site 412022008435 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 412022008436 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 412022008437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022008438 DNA-binding site [nucleotide binding]; DNA binding site 412022008439 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 412022008440 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 412022008441 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 412022008442 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 412022008443 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 412022008444 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 412022008445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022008446 Walker A/P-loop; other site 412022008447 ATP binding site [chemical binding]; other site 412022008448 Q-loop/lid; other site 412022008449 ABC transporter signature motif; other site 412022008450 Walker B; other site 412022008451 D-loop; other site 412022008452 H-loop/switch region; other site 412022008453 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022008454 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 412022008455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022008456 Walker A/P-loop; other site 412022008457 ATP binding site [chemical binding]; other site 412022008458 Q-loop/lid; other site 412022008459 ABC transporter signature motif; other site 412022008460 Walker B; other site 412022008461 D-loop; other site 412022008462 H-loop/switch region; other site 412022008463 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 412022008464 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022008465 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 412022008466 active site 412022008467 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 412022008468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022008469 Walker A/P-loop; other site 412022008470 ATP binding site [chemical binding]; other site 412022008471 Q-loop/lid; other site 412022008472 ABC transporter signature motif; other site 412022008473 Walker B; other site 412022008474 D-loop; other site 412022008475 H-loop/switch region; other site 412022008476 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 412022008477 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 412022008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022008479 dimer interface [polypeptide binding]; other site 412022008480 conserved gate region; other site 412022008481 ABC-ATPase subunit interface; other site 412022008482 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 412022008483 pyrroline-5-carboxylate reductase; Region: PLN02688 412022008484 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 412022008485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022008486 catalytic residue [active] 412022008487 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 412022008488 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412022008489 Cysteine-rich domain; Region: CCG; pfam02754 412022008490 Cysteine-rich domain; Region: CCG; pfam02754 412022008491 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 412022008492 FAD binding domain; Region: FAD_binding_4; pfam01565 412022008493 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 412022008494 FAD binding domain; Region: FAD_binding_4; pfam01565 412022008495 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412022008496 FAD binding domain; Region: FAD_binding_4; pfam01565 412022008497 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 412022008498 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 412022008499 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 412022008500 heme-binding site [chemical binding]; other site 412022008501 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 412022008502 FAD binding pocket [chemical binding]; other site 412022008503 FAD binding motif [chemical binding]; other site 412022008504 phosphate binding motif [ion binding]; other site 412022008505 beta-alpha-beta structure motif; other site 412022008506 NAD binding pocket [chemical binding]; other site 412022008507 Heme binding pocket [chemical binding]; other site 412022008508 Transposase domain (DUF772); Region: DUF772; pfam05598 412022008509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022008510 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022008511 OsmC-like protein; Region: OsmC; cl00767 412022008512 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 412022008513 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 412022008514 active site 412022008515 substrate binding pocket [chemical binding]; other site 412022008516 dimer interface [polypeptide binding]; other site 412022008517 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 412022008518 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 412022008519 putative active site [active] 412022008520 putative dimer interface [polypeptide binding]; other site 412022008521 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412022008522 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412022008523 putative dimer interface [polypeptide binding]; other site 412022008524 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412022008525 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412022008526 putative dimer interface [polypeptide binding]; other site 412022008527 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 412022008528 oligomerisation interface [polypeptide binding]; other site 412022008529 mobile loop; other site 412022008530 roof hairpin; other site 412022008531 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412022008532 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022008533 Walker A/P-loop; other site 412022008534 ATP binding site [chemical binding]; other site 412022008535 Q-loop/lid; other site 412022008536 ABC transporter signature motif; other site 412022008537 Walker B; other site 412022008538 D-loop; other site 412022008539 H-loop/switch region; other site 412022008540 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022008541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022008542 dimer interface [polypeptide binding]; other site 412022008543 conserved gate region; other site 412022008544 putative PBP binding loops; other site 412022008545 ABC-ATPase subunit interface; other site 412022008546 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022008547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022008548 dimer interface [polypeptide binding]; other site 412022008549 conserved gate region; other site 412022008550 putative PBP binding loops; other site 412022008551 ABC-ATPase subunit interface; other site 412022008552 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 412022008553 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 412022008554 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 412022008555 NAD(P) binding site [chemical binding]; other site 412022008556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022008557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022008558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022008559 dimerization interface [polypeptide binding]; other site 412022008560 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 412022008561 adenylosuccinate lyase; Provisional; Region: PRK09285 412022008562 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 412022008563 tetramer interface [polypeptide binding]; other site 412022008564 active site 412022008565 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 412022008566 ATP-binding site [chemical binding]; other site 412022008567 Gluconate-6-phosphate binding site [chemical binding]; other site 412022008568 Shikimate kinase; Region: SKI; pfam01202 412022008569 GntP family permease; Region: GntP_permease; pfam02447 412022008570 fructuronate transporter; Provisional; Region: PRK10034; cl15264 412022008571 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 412022008572 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 412022008573 active site 412022008574 intersubunit interface [polypeptide binding]; other site 412022008575 catalytic residue [active] 412022008576 phosphogluconate dehydratase; Validated; Region: PRK09054 412022008577 6-phosphogluconate dehydratase; Region: edd; TIGR01196 412022008578 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022008579 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022008580 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412022008581 putative active site [active] 412022008582 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 412022008583 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 412022008584 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 412022008585 putative catalytic cysteine [active] 412022008586 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 412022008587 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 412022008588 Lipopolysaccharide-assembly; Region: LptE; cl01125 412022008589 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 412022008590 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 412022008591 HIGH motif; other site 412022008592 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412022008593 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022008594 active site 412022008595 KMSKS motif; other site 412022008596 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 412022008597 tRNA binding surface [nucleotide binding]; other site 412022008598 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412022008599 TolR protein; Region: tolR; TIGR02801 412022008600 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 412022008601 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 412022008602 dihydrodipicolinate reductase; Provisional; Region: PRK00048 412022008603 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 412022008604 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 412022008605 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 412022008606 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 412022008607 ferric uptake regulator; Provisional; Region: fur; PRK09462 412022008608 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412022008609 metal binding site 2 [ion binding]; metal-binding site 412022008610 putative DNA binding helix; other site 412022008611 metal binding site 1 [ion binding]; metal-binding site 412022008612 dimer interface [polypeptide binding]; other site 412022008613 structural Zn2+ binding site [ion binding]; other site 412022008614 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 412022008615 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 412022008616 allantoicase; Provisional; Region: PRK13257 412022008617 Allantoicase repeat; Region: Allantoicase; pfam03561 412022008618 Allantoicase repeat; Region: Allantoicase; pfam03561 412022008619 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412022008620 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 412022008621 HTH-like domain; Region: HTH_21; pfam13276 412022008622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022008623 Integrase core domain; Region: rve; pfam00665 412022008624 Integrase core domain; Region: rve_3; pfam13683 412022008625 Transposase; Region: HTH_Tnp_1; pfam01527 412022008626 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412022008627 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 412022008628 Transcriptional regulators [Transcription]; Region: FadR; COG2186 412022008629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022008630 DNA-binding site [nucleotide binding]; DNA binding site 412022008631 FCD domain; Region: FCD; pfam07729 412022008632 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 412022008633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022008634 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 412022008635 dimerization interface [polypeptide binding]; other site 412022008636 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 412022008637 active site clefts [active] 412022008638 zinc binding site [ion binding]; other site 412022008639 dimer interface [polypeptide binding]; other site 412022008640 cyanate hydratase; Validated; Region: PRK02866 412022008641 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 412022008642 oligomer interface [polypeptide binding]; other site 412022008643 active site 412022008644 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412022008645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022008646 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 412022008647 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 412022008648 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 412022008649 transketolase; Reviewed; Region: PRK12753 412022008650 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 412022008651 TPP-binding site [chemical binding]; other site 412022008652 dimer interface [polypeptide binding]; other site 412022008653 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412022008654 PYR/PP interface [polypeptide binding]; other site 412022008655 dimer interface [polypeptide binding]; other site 412022008656 TPP binding site [chemical binding]; other site 412022008657 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412022008658 spermidine synthase; Provisional; Region: PRK00811 412022008659 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 412022008660 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 412022008661 putative dimer interface [polypeptide binding]; other site 412022008662 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022008663 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 412022008664 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 412022008665 putative RNAase interaction site [polypeptide binding]; other site 412022008666 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 412022008667 active site 412022008668 barstar interaction site; other site 412022008669 malic enzyme; Reviewed; Region: PRK12862 412022008670 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412022008671 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 412022008672 putative NAD(P) binding site [chemical binding]; other site 412022008673 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 412022008674 thiamine monophosphate kinase; Provisional; Region: PRK05731 412022008675 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 412022008676 ATP binding site [chemical binding]; other site 412022008677 dimerization interface [polypeptide binding]; other site 412022008678 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 412022008679 tetramer interfaces [polypeptide binding]; other site 412022008680 binuclear metal-binding site [ion binding]; other site 412022008681 Competence-damaged protein; Region: CinA; pfam02464 412022008682 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 412022008683 active site 412022008684 dimer interface [polypeptide binding]; other site 412022008685 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 412022008686 active site 412022008687 catalytic residues [active] 412022008688 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 412022008689 classical (c) SDRs; Region: SDR_c; cd05233 412022008690 NAD(P) binding site [chemical binding]; other site 412022008691 active site 412022008692 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022008693 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412022008694 TM-ABC transporter signature motif; other site 412022008695 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 412022008696 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412022008697 Walker A/P-loop; other site 412022008698 ATP binding site [chemical binding]; other site 412022008699 Q-loop/lid; other site 412022008700 ABC transporter signature motif; other site 412022008701 Walker B; other site 412022008702 D-loop; other site 412022008703 H-loop/switch region; other site 412022008704 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412022008705 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 412022008706 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 412022008707 ligand binding site [chemical binding]; other site 412022008708 short chain dehydrogenase; Provisional; Region: PRK07063 412022008709 classical (c) SDRs; Region: SDR_c; cd05233 412022008710 NAD(P) binding site [chemical binding]; other site 412022008711 active site 412022008712 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 412022008713 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 412022008714 active site 412022008715 intersubunit interface [polypeptide binding]; other site 412022008716 catalytic residue [active] 412022008717 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 412022008718 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 412022008719 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022008720 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022008721 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022008722 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 412022008723 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 412022008724 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 412022008725 Transglycosylase; Region: Transgly; cl17702 412022008726 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 412022008727 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 412022008728 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 412022008729 shikimate binding site; other site 412022008730 NAD(P) binding site [chemical binding]; other site 412022008731 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 412022008732 RNB domain; Region: RNB; pfam00773 412022008733 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 412022008734 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412022008735 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 412022008736 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412022008737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412022008738 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412022008739 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412022008740 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022008741 catalytic residues [active] 412022008742 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 412022008743 Dehydroquinase class II; Region: DHquinase_II; pfam01220 412022008744 active site 412022008745 trimer interface [polypeptide binding]; other site 412022008746 dimer interface [polypeptide binding]; other site 412022008747 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 412022008748 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412022008749 carboxyltransferase (CT) interaction site; other site 412022008750 biotinylation site [posttranslational modification]; other site 412022008751 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 412022008752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412022008753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412022008754 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412022008755 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 412022008756 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412022008757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022008758 S-adenosylmethionine binding site [chemical binding]; other site 412022008759 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 412022008760 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 412022008761 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 412022008762 dimer interface [polypeptide binding]; other site 412022008763 catalytic triad [active] 412022008764 peroxidatic and resolving cysteines [active] 412022008765 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412022008766 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 412022008767 substrate binding site [chemical binding]; other site 412022008768 ATP binding site [chemical binding]; other site 412022008769 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 412022008770 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 412022008771 dimer interface [polypeptide binding]; other site 412022008772 putative radical transfer pathway; other site 412022008773 diiron center [ion binding]; other site 412022008774 tyrosyl radical; other site 412022008775 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 412022008776 ATP cone domain; Region: ATP-cone; pfam03477 412022008777 Class I ribonucleotide reductase; Region: RNR_I; cd01679 412022008778 active site 412022008779 dimer interface [polypeptide binding]; other site 412022008780 catalytic residues [active] 412022008781 effector binding site; other site 412022008782 R2 peptide binding site; other site 412022008783 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 412022008784 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412022008785 amidase catalytic site [active] 412022008786 Zn binding residues [ion binding]; other site 412022008787 substrate binding site [chemical binding]; other site 412022008788 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412022008789 signal recognition particle protein; Provisional; Region: PRK10867 412022008790 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 412022008791 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412022008792 P loop; other site 412022008793 GTP binding site [chemical binding]; other site 412022008794 Signal peptide binding domain; Region: SRP_SPB; pfam02978 412022008795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022008796 active site 412022008797 MarC family integral membrane protein; Region: MarC; cl00919 412022008798 prolyl-tRNA synthetase; Provisional; Region: PRK09194 412022008799 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 412022008800 dimer interface [polypeptide binding]; other site 412022008801 motif 1; other site 412022008802 active site 412022008803 motif 2; other site 412022008804 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 412022008805 putative deacylase active site [active] 412022008806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412022008807 active site 412022008808 motif 3; other site 412022008809 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 412022008810 anticodon binding site; other site 412022008811 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 412022008812 putative active site [active] 412022008813 Ap4A binding site [chemical binding]; other site 412022008814 nudix motif; other site 412022008815 putative metal binding site [ion binding]; other site 412022008816 CNP1-like family; Region: CNP1; pfam08750 412022008817 Transposase domain (DUF772); Region: DUF772; pfam05598 412022008818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022008819 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022008820 gamma-glutamyl kinase; Provisional; Region: PRK05429 412022008821 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 412022008822 nucleotide binding site [chemical binding]; other site 412022008823 homotetrameric interface [polypeptide binding]; other site 412022008824 putative phosphate binding site [ion binding]; other site 412022008825 putative allosteric binding site; other site 412022008826 PUA domain; Region: PUA; pfam01472 412022008827 GTPase CgtA; Reviewed; Region: obgE; PRK12298 412022008828 GTP1/OBG; Region: GTP1_OBG; pfam01018 412022008829 Obg GTPase; Region: Obg; cd01898 412022008830 G1 box; other site 412022008831 GTP/Mg2+ binding site [chemical binding]; other site 412022008832 Switch I region; other site 412022008833 G2 box; other site 412022008834 G3 box; other site 412022008835 Switch II region; other site 412022008836 G4 box; other site 412022008837 G5 box; other site 412022008838 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 412022008839 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 412022008840 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 412022008841 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412022008842 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412022008843 substrate binding pocket [chemical binding]; other site 412022008844 chain length determination region; other site 412022008845 substrate-Mg2+ binding site; other site 412022008846 catalytic residues [active] 412022008847 aspartate-rich region 1; other site 412022008848 active site lid residues [active] 412022008849 aspartate-rich region 2; other site 412022008850 HTH-like domain; Region: HTH_21; pfam13276 412022008851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022008852 Integrase core domain; Region: rve; pfam00665 412022008853 Integrase core domain; Region: rve_3; pfam13683 412022008854 Transposase; Region: HTH_Tnp_1; pfam01527 412022008855 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 412022008856 Domain of unknown function DUF21; Region: DUF21; pfam01595 412022008857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412022008858 Transporter associated domain; Region: CorC_HlyC; smart01091 412022008859 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412022008860 Walker A motif; other site 412022008861 ATP binding site [chemical binding]; other site 412022008862 Walker B motif; other site 412022008863 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 412022008864 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022008865 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022008866 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 412022008867 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 412022008868 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 412022008869 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 412022008870 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 412022008871 CoA-binding site [chemical binding]; other site 412022008872 ATP-binding [chemical binding]; other site 412022008873 hypothetical protein; Provisional; Region: PRK05287 412022008874 Domain of unknown function (DUF329); Region: DUF329; pfam03884 412022008875 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 412022008876 active site 412022008877 8-oxo-dGMP binding site [chemical binding]; other site 412022008878 nudix motif; other site 412022008879 metal binding site [ion binding]; metal-binding site 412022008880 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 412022008881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022008882 Walker A motif; other site 412022008883 ATP binding site [chemical binding]; other site 412022008884 Walker B motif; other site 412022008885 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 412022008886 heterotetramer interface [polypeptide binding]; other site 412022008887 active site pocket [active] 412022008888 cleavage site 412022008889 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 412022008890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 412022008891 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 412022008892 SEC-C motif; Region: SEC-C; pfam02810 412022008893 Protein of unknown function (DUF721); Region: DUF721; pfam05258 412022008894 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 412022008895 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 412022008896 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 412022008897 catalytic triad [active] 412022008898 dimer interface [polypeptide binding]; other site 412022008899 cell division protein FtsZ; Validated; Region: PRK09330 412022008900 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 412022008901 nucleotide binding site [chemical binding]; other site 412022008902 SulA interaction site; other site 412022008903 cell division protein FtsA; Region: ftsA; TIGR01174 412022008904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 412022008905 nucleotide binding site [chemical binding]; other site 412022008906 Cell division protein FtsA; Region: FtsA; pfam14450 412022008907 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 412022008908 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 412022008909 Cell division protein FtsQ; Region: FtsQ; pfam03799 412022008910 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 412022008911 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 412022008912 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412022008913 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 412022008914 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412022008915 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412022008916 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412022008917 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 412022008918 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412022008919 active site 412022008920 homodimer interface [polypeptide binding]; other site 412022008921 cell division protein FtsW; Region: ftsW; TIGR02614 412022008922 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 412022008923 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412022008924 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412022008925 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 412022008926 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 412022008927 Mg++ binding site [ion binding]; other site 412022008928 putative catalytic motif [active] 412022008929 putative substrate binding site [chemical binding]; other site 412022008930 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 412022008931 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412022008932 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412022008933 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412022008934 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 412022008935 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412022008936 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412022008937 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412022008938 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412022008939 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412022008940 Cell division protein FtsL; Region: FtsL; pfam04999 412022008941 MraW methylase family; Region: Methyltransf_5; cl17771 412022008942 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 412022008943 cell division protein MraZ; Reviewed; Region: PRK00326 412022008944 MraZ protein; Region: MraZ; pfam02381 412022008945 MraZ protein; Region: MraZ; pfam02381 412022008946 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 412022008947 diiron binding motif [ion binding]; other site 412022008948 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022008949 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022008950 trimer interface [polypeptide binding]; other site 412022008951 eyelet of channel; other site 412022008952 Transposase domain (DUF772); Region: DUF772; pfam05598 412022008953 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022008954 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022008955 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 412022008956 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 412022008957 substrate binding pocket [chemical binding]; other site 412022008958 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 412022008959 B12 binding site [chemical binding]; other site 412022008960 cobalt ligand [ion binding]; other site 412022008961 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 412022008962 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 412022008963 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 412022008964 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 412022008965 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 412022008966 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022008967 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022008968 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022008969 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 412022008970 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412022008971 enoyl-CoA hydratase; Provisional; Region: PRK07657 412022008972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022008973 substrate binding site [chemical binding]; other site 412022008974 oxyanion hole (OAH) forming residues; other site 412022008975 trimer interface [polypeptide binding]; other site 412022008976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 412022008977 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 412022008978 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 412022008979 active site 412022008980 nucleophile elbow; other site 412022008981 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 412022008982 dinuclear metal binding motif [ion binding]; other site 412022008983 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 412022008984 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 412022008985 active site 412022008986 HIGH motif; other site 412022008987 nucleotide binding site [chemical binding]; other site 412022008988 pantothenate kinase; Reviewed; Region: PRK13328 412022008989 biotin--protein ligase; Provisional; Region: PRK06955 412022008990 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 412022008991 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412022008992 Sel1-like repeats; Region: SEL1; smart00671 412022008993 Sel1-like repeats; Region: SEL1; smart00671 412022008994 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 412022008995 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 412022008996 active site 412022008997 metal binding site [ion binding]; metal-binding site 412022008998 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412022008999 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 412022009000 Permease; Region: Permease; pfam02405 412022009001 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 412022009002 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 412022009003 Walker A/P-loop; other site 412022009004 ATP binding site [chemical binding]; other site 412022009005 Q-loop/lid; other site 412022009006 ABC transporter signature motif; other site 412022009007 Walker B; other site 412022009008 D-loop; other site 412022009009 H-loop/switch region; other site 412022009010 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 412022009011 mce related protein; Region: MCE; pfam02470 412022009012 Protein of unknown function (DUF330); Region: DUF330; pfam03886 412022009013 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 412022009014 dimer interface [polypeptide binding]; other site 412022009015 [2Fe-2S] cluster binding site [ion binding]; other site 412022009016 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 412022009017 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412022009018 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412022009019 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 412022009020 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412022009021 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412022009022 homodimer interface [polypeptide binding]; other site 412022009023 substrate-cofactor binding pocket; other site 412022009024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009025 catalytic residue [active] 412022009026 hypothetical protein; Provisional; Region: PRK02047 412022009027 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022009028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022009029 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 412022009030 dimerization interface [polypeptide binding]; other site 412022009031 substrate binding pocket [chemical binding]; other site 412022009032 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 412022009033 lipoate-protein ligase B; Provisional; Region: PRK14343 412022009034 lipoyl synthase; Provisional; Region: PRK05481 412022009035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022009036 FeS/SAM binding site; other site 412022009037 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009039 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009040 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412022009041 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 412022009042 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 412022009043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022009044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022009045 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022009046 putative effector binding pocket; other site 412022009047 dimerization interface [polypeptide binding]; other site 412022009048 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 412022009049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022009050 substrate binding site [chemical binding]; other site 412022009051 oxyanion hole (OAH) forming residues; other site 412022009052 trimer interface [polypeptide binding]; other site 412022009053 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412022009054 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022009055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022009056 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 412022009057 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022009058 active site 412022009059 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 412022009060 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 412022009061 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 412022009062 active site 412022009063 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022009064 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022009065 Protein of unknown function, DUF485; Region: DUF485; pfam04341 412022009066 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 412022009067 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 412022009068 Na binding site [ion binding]; other site 412022009069 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 412022009070 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412022009071 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 412022009072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022009073 ATP binding site [chemical binding]; other site 412022009074 Mg2+ binding site [ion binding]; other site 412022009075 G-X-G motif; other site 412022009076 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022009077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022009078 active site 412022009079 phosphorylation site [posttranslational modification] 412022009080 intermolecular recognition site; other site 412022009081 dimerization interface [polypeptide binding]; other site 412022009082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022009083 Walker A motif; other site 412022009084 ATP binding site [chemical binding]; other site 412022009085 Walker B motif; other site 412022009086 arginine finger; other site 412022009087 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022009088 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412022009089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022009090 catalytic residues [active] 412022009091 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 412022009092 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412022009093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022009094 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 412022009095 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 412022009096 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 412022009097 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 412022009098 Membrane fusogenic activity; Region: BMFP; pfam04380 412022009099 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 412022009100 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412022009101 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 412022009102 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009103 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009104 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009105 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 412022009106 Glutamate-cysteine ligase; Region: GshA; pfam08886 412022009107 glutathione synthetase; Provisional; Region: PRK05246 412022009108 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 412022009109 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 412022009110 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 412022009111 active pocket/dimerization site; other site 412022009112 active site 412022009113 phosphorylation site [posttranslational modification] 412022009114 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 412022009115 dimerization domain swap beta strand [polypeptide binding]; other site 412022009116 regulatory protein interface [polypeptide binding]; other site 412022009117 active site 412022009118 regulatory phosphorylation site [posttranslational modification]; other site 412022009119 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 412022009120 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 412022009121 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 412022009122 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 412022009123 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 412022009124 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412022009125 ATP binding site [chemical binding]; other site 412022009126 substrate interface [chemical binding]; other site 412022009127 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 412022009128 C-terminal peptidase (prc); Region: prc; TIGR00225 412022009129 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 412022009130 protein binding site [polypeptide binding]; other site 412022009131 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 412022009132 Catalytic dyad [active] 412022009133 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412022009134 catalytic core [active] 412022009135 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412022009136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412022009137 active site residue [active] 412022009138 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 412022009139 GSH binding site [chemical binding]; other site 412022009140 catalytic residues [active] 412022009141 preprotein translocase subunit SecB; Validated; Region: PRK05751 412022009142 SecA binding site; other site 412022009143 Preprotein binding site; other site 412022009144 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 412022009145 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 412022009146 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 412022009147 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 412022009148 putative ADP-ribose binding site [chemical binding]; other site 412022009149 putative active site [active] 412022009150 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 412022009151 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 412022009152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022009153 active site 412022009154 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 412022009155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022009156 S-adenosylmethionine binding site [chemical binding]; other site 412022009157 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 412022009158 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 412022009159 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 412022009160 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 412022009161 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412022009162 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 412022009163 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 412022009164 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022009165 ligand binding site [chemical binding]; other site 412022009166 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412022009167 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 412022009168 Subunit I/III interface [polypeptide binding]; other site 412022009169 D-pathway; other site 412022009170 Subunit I/VIIc interface [polypeptide binding]; other site 412022009171 Subunit I/IV interface [polypeptide binding]; other site 412022009172 Subunit I/II interface [polypeptide binding]; other site 412022009173 Low-spin heme (heme a) binding site [chemical binding]; other site 412022009174 Subunit I/VIIa interface [polypeptide binding]; other site 412022009175 Subunit I/VIa interface [polypeptide binding]; other site 412022009176 Dimer interface; other site 412022009177 Putative water exit pathway; other site 412022009178 Binuclear center (heme a3/CuB) [ion binding]; other site 412022009179 K-pathway; other site 412022009180 Subunit I/Vb interface [polypeptide binding]; other site 412022009181 Putative proton exit pathway; other site 412022009182 Subunit I/VIb interface; other site 412022009183 Subunit I/VIc interface [polypeptide binding]; other site 412022009184 Electron transfer pathway; other site 412022009185 Subunit I/VIIIb interface [polypeptide binding]; other site 412022009186 Subunit I/VIIb interface [polypeptide binding]; other site 412022009187 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 412022009188 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 412022009189 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 412022009190 Subunit III/VIIa interface [polypeptide binding]; other site 412022009191 Phospholipid binding site [chemical binding]; other site 412022009192 Subunit I/III interface [polypeptide binding]; other site 412022009193 Subunit III/VIb interface [polypeptide binding]; other site 412022009194 Subunit III/VIa interface; other site 412022009195 Subunit III/Vb interface [polypeptide binding]; other site 412022009196 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 412022009197 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 412022009198 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 412022009199 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 412022009200 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 412022009201 UbiA prenyltransferase family; Region: UbiA; pfam01040 412022009202 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 412022009203 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412022009204 Cu(I) binding site [ion binding]; other site 412022009205 YCII-related domain; Region: YCII; cl00999 412022009206 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 412022009207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 412022009208 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412022009209 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022009210 dimer interface [polypeptide binding]; other site 412022009211 putative CheW interface [polypeptide binding]; other site 412022009212 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412022009213 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412022009214 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009215 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009216 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022009218 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022009219 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 412022009220 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 412022009221 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 412022009222 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 412022009223 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 412022009224 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 412022009225 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 412022009226 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 412022009227 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 412022009228 active site 412022009229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412022009230 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 412022009231 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412022009232 active site turn [active] 412022009233 phosphorylation site [posttranslational modification] 412022009234 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 412022009235 HPr interaction site; other site 412022009236 glycerol kinase (GK) interaction site [polypeptide binding]; other site 412022009237 active site 412022009238 phosphorylation site [posttranslational modification] 412022009239 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 412022009240 dimerization domain swap beta strand [polypeptide binding]; other site 412022009241 regulatory protein interface [polypeptide binding]; other site 412022009242 active site 412022009243 regulatory phosphorylation site [posttranslational modification]; other site 412022009244 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 412022009245 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 412022009246 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 412022009247 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 412022009248 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 412022009249 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 412022009250 dimer interface [polypeptide binding]; other site 412022009251 active site 412022009252 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 412022009253 dimer interface [polypeptide binding]; other site 412022009254 active site 412022009255 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 412022009256 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 412022009257 active site 412022009258 dimer interface [polypeptide binding]; other site 412022009259 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412022009260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022009261 DNA-binding site [nucleotide binding]; DNA binding site 412022009262 UTRA domain; Region: UTRA; pfam07702 412022009263 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 412022009264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022009265 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 412022009266 dimerization interface [polypeptide binding]; other site 412022009267 substrate binding pocket [chemical binding]; other site 412022009268 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 412022009269 acyl-CoA synthetase; Validated; Region: PRK09192 412022009270 acyl-activating enzyme (AAE) consensus motif; other site 412022009271 active site 412022009272 Phosphopantetheine attachment site; Region: PP-binding; cl09936 412022009273 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 412022009274 dinuclear metal binding motif [ion binding]; other site 412022009275 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 412022009276 active site 412022009277 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 412022009278 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 412022009279 dimer interface [polypeptide binding]; other site 412022009280 active site 412022009281 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022009282 catalytic residues [active] 412022009283 substrate binding site [chemical binding]; other site 412022009284 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 412022009285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022009286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022009287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022009288 acyl-activating enzyme (AAE) consensus motif; other site 412022009289 acyl-activating enzyme (AAE) consensus motif; other site 412022009290 AMP binding site [chemical binding]; other site 412022009291 active site 412022009292 CoA binding site [chemical binding]; other site 412022009293 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 412022009294 active site 412022009295 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 412022009296 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022009297 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022009298 active site 412022009299 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 412022009300 Citrate synthase; Region: Citrate_synt; pfam00285 412022009301 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 412022009302 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 412022009303 citrylCoA binding site [chemical binding]; other site 412022009304 oxalacetate binding site [chemical binding]; other site 412022009305 coenzyme A binding site [chemical binding]; other site 412022009306 catalytic triad [active] 412022009307 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022009308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022009309 S-adenosylmethionine binding site [chemical binding]; other site 412022009310 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022009311 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 412022009312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022009313 Walker A/P-loop; other site 412022009314 ATP binding site [chemical binding]; other site 412022009315 Q-loop/lid; other site 412022009316 ABC transporter signature motif; other site 412022009317 Walker B; other site 412022009318 D-loop; other site 412022009319 H-loop/switch region; other site 412022009320 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 412022009321 ABC-2 type transporter; Region: ABC2_membrane; cl17235 412022009322 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 412022009323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022009324 inhibitor-cofactor binding pocket; inhibition site 412022009325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009326 catalytic residue [active] 412022009327 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 412022009328 Fatty acid desaturase; Region: FA_desaturase; pfam00487 412022009329 putative di-iron ligands [ion binding]; other site 412022009330 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 412022009331 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 412022009332 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 412022009333 putative active site [active] 412022009334 putative PHP Thumb interface [polypeptide binding]; other site 412022009335 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 412022009336 generic binding surface II; other site 412022009337 generic binding surface I; other site 412022009338 DNA Polymerase Y-family; Region: PolY_like; cd03468 412022009339 active site 412022009340 DNA binding site [nucleotide binding] 412022009341 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 412022009342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022009343 Walker A/P-loop; other site 412022009344 ATP binding site [chemical binding]; other site 412022009345 Q-loop/lid; other site 412022009346 ABC transporter signature motif; other site 412022009347 Walker B; other site 412022009348 D-loop; other site 412022009349 H-loop/switch region; other site 412022009350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022009351 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 412022009352 TM-ABC transporter signature motif; other site 412022009353 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 412022009354 zinc binding site [ion binding]; other site 412022009355 putative ligand binding site [chemical binding]; other site 412022009356 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009358 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009359 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 412022009360 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412022009361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022009362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022009363 DNA binding residues [nucleotide binding] 412022009364 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 412022009365 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 412022009366 SnoaL-like domain; Region: SnoaL_3; pfam13474 412022009367 2-isopropylmalate synthase; Validated; Region: PRK03739 412022009368 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 412022009369 active site 412022009370 catalytic residues [active] 412022009371 metal binding site [ion binding]; metal-binding site 412022009372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022009373 Coenzyme A binding pocket [chemical binding]; other site 412022009374 glycosyl transferase family protein; Provisional; Region: PRK08136 412022009375 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412022009376 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926 412022009377 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 412022009378 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 412022009379 molybdopterin cofactor binding site; other site 412022009380 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 412022009381 molybdopterin cofactor binding site; other site 412022009382 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412022009383 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 412022009384 [2Fe-2S] cluster binding site [ion binding]; other site 412022009385 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 412022009386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022009387 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412022009388 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412022009389 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022009390 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 412022009391 maleylacetoacetate isomerase; Region: maiA; TIGR01262 412022009392 C-terminal domain interface [polypeptide binding]; other site 412022009393 GSH binding site (G-site) [chemical binding]; other site 412022009394 putative dimer interface [polypeptide binding]; other site 412022009395 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 412022009396 dimer interface [polypeptide binding]; other site 412022009397 N-terminal domain interface [polypeptide binding]; other site 412022009398 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 412022009399 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 412022009400 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 412022009401 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412022009402 P loop; other site 412022009403 GTP binding site [chemical binding]; other site 412022009404 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 412022009405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022009406 S-adenosylmethionine binding site [chemical binding]; other site 412022009407 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 412022009408 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 412022009409 active site 412022009410 (T/H)XGH motif; other site 412022009411 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 412022009412 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 412022009413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022009414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009415 homodimer interface [polypeptide binding]; other site 412022009416 catalytic residue [active] 412022009417 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 412022009418 putative active site [active] 412022009419 catalytic residue [active] 412022009420 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 412022009421 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 412022009422 5S rRNA interface [nucleotide binding]; other site 412022009423 CTC domain interface [polypeptide binding]; other site 412022009424 L16 interface [polypeptide binding]; other site 412022009425 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 412022009426 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 412022009427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022009428 active site 412022009429 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 412022009430 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 412022009431 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 412022009432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412022009433 binding surface 412022009434 TPR motif; other site 412022009435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022009436 binding surface 412022009437 TPR motif; other site 412022009438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022009439 binding surface 412022009440 TPR motif; other site 412022009441 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 412022009442 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 412022009443 DNA binding site [nucleotide binding] 412022009444 catalytic residue [active] 412022009445 H2TH interface [polypeptide binding]; other site 412022009446 putative catalytic residues [active] 412022009447 turnover-facilitating residue; other site 412022009448 intercalation triad [nucleotide binding]; other site 412022009449 8OG recognition residue [nucleotide binding]; other site 412022009450 putative reading head residues; other site 412022009451 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 412022009452 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412022009453 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 412022009454 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412022009455 minor groove reading motif; other site 412022009456 helix-hairpin-helix signature motif; other site 412022009457 active site 412022009458 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 412022009459 DNA binding and oxoG recognition site [nucleotide binding] 412022009460 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 412022009461 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 412022009462 HPr kinase/phosphorylase; Provisional; Region: PRK05428 412022009463 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 412022009464 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 412022009465 Hpr binding site; other site 412022009466 active site 412022009467 homohexamer subunit interaction site [polypeptide binding]; other site 412022009468 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412022009469 active site 412022009470 phosphorylation site [posttranslational modification] 412022009471 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 412022009472 30S subunit binding site; other site 412022009473 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 412022009474 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 412022009475 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 412022009476 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 412022009477 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 412022009478 Walker A/P-loop; other site 412022009479 ATP binding site [chemical binding]; other site 412022009480 Q-loop/lid; other site 412022009481 ABC transporter signature motif; other site 412022009482 Walker B; other site 412022009483 D-loop; other site 412022009484 H-loop/switch region; other site 412022009485 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 412022009486 OstA-like protein; Region: OstA; pfam03968 412022009487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 412022009488 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 412022009489 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 412022009490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022009491 active site 412022009492 motif I; other site 412022009493 motif II; other site 412022009494 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 412022009495 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 412022009496 putative active site [active] 412022009497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 412022009498 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412022009499 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 412022009500 TrkA-N domain; Region: TrkA_N; pfam02254 412022009501 TrkA-C domain; Region: TrkA_C; pfam02080 412022009502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022009503 active site 412022009504 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022009505 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 412022009506 nudix motif; other site 412022009507 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 412022009508 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 412022009509 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 412022009510 putative active site [active] 412022009511 putative substrate binding site [chemical binding]; other site 412022009512 putative cosubstrate binding site; other site 412022009513 catalytic site [active] 412022009514 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412022009515 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 412022009516 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412022009517 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412022009518 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 412022009519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022009520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022009521 putative substrate translocation pore; other site 412022009522 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 412022009523 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 412022009524 dimer interface [polypeptide binding]; other site 412022009525 ssDNA binding site [nucleotide binding]; other site 412022009526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412022009527 Transposase; Region: HTH_Tnp_1; pfam01527 412022009528 HTH-like domain; Region: HTH_21; pfam13276 412022009529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022009530 Integrase core domain; Region: rve; pfam00665 412022009531 Integrase core domain; Region: rve_3; pfam13683 412022009532 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 412022009533 Int/Topo IB signature motif; other site 412022009534 Cytochrome c; Region: Cytochrom_C; cl11414 412022009535 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 412022009536 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 412022009537 Part of AAA domain; Region: AAA_19; pfam13245 412022009538 Family description; Region: UvrD_C_2; pfam13538 412022009539 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 412022009540 catalytic triad [active] 412022009541 putative oxidoreductase; Provisional; Region: PRK11579 412022009542 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412022009543 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 412022009544 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 412022009545 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 412022009546 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 412022009547 lipoyl attachment site [posttranslational modification]; other site 412022009548 glycine dehydrogenase; Provisional; Region: PRK05367 412022009549 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 412022009550 tetramer interface [polypeptide binding]; other site 412022009551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009552 catalytic residue [active] 412022009553 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 412022009554 tetramer interface [polypeptide binding]; other site 412022009555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009556 catalytic residue [active] 412022009557 Alginate lyase; Region: Alginate_lyase; pfam05426 412022009558 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 412022009559 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 412022009560 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 412022009561 thiamine pyrophosphate protein; Validated; Region: PRK08199 412022009562 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022009563 PYR/PP interface [polypeptide binding]; other site 412022009564 dimer interface [polypeptide binding]; other site 412022009565 TPP binding site [chemical binding]; other site 412022009566 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022009567 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 412022009568 TPP-binding site [chemical binding]; other site 412022009569 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022009570 Helix-turn-helix domain; Region: HTH_18; pfam12833 412022009571 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 412022009572 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022009573 NAD(P) binding site [chemical binding]; other site 412022009574 catalytic residues [active] 412022009575 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 412022009576 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 412022009577 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 412022009578 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009580 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009581 ethanolamine permease; Region: 2A0305; TIGR00908 412022009582 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 412022009583 Acyltransferase family; Region: Acyl_transf_3; pfam01757 412022009584 Conserved TM helix; Region: TM_helix; pfam05552 412022009585 Conserved TM helix; Region: TM_helix; pfam05552 412022009586 Conserved TM helix; Region: TM_helix; pfam05552 412022009587 Double zinc ribbon; Region: DZR; pfam12773 412022009588 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412022009589 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 412022009590 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412022009591 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412022009592 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 412022009593 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 412022009594 DNA binding residues [nucleotide binding] 412022009595 dimer interface [polypeptide binding]; other site 412022009596 putative metal binding site [ion binding]; other site 412022009597 Predicted transcriptional regulators [Transcription]; Region: COG1695 412022009598 Transcriptional regulator PadR-like family; Region: PadR; cl17335 412022009599 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 412022009600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022009601 substrate binding pocket [chemical binding]; other site 412022009602 membrane-bound complex binding site; other site 412022009603 hinge residues; other site 412022009604 putative aminotransferase; Provisional; Region: PRK12414 412022009605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022009606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009607 homodimer interface [polypeptide binding]; other site 412022009608 catalytic residue [active] 412022009609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022009610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022009611 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 412022009612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022009613 active site 412022009614 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 412022009615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022009616 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 412022009617 acyl-activating enzyme (AAE) consensus motif; other site 412022009618 acyl-activating enzyme (AAE) consensus motif; other site 412022009619 putative AMP binding site [chemical binding]; other site 412022009620 putative active site [active] 412022009621 putative CoA binding site [chemical binding]; other site 412022009622 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 412022009623 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 412022009624 dimerization interface [polypeptide binding]; other site 412022009625 ligand binding site [chemical binding]; other site 412022009626 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 412022009627 Predicted transcriptional regulator [Transcription]; Region: COG3905 412022009628 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 412022009629 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 412022009630 Glutamate binding site [chemical binding]; other site 412022009631 NAD binding site [chemical binding]; other site 412022009632 catalytic residues [active] 412022009633 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022009634 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 412022009635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022009636 ATP binding site [chemical binding]; other site 412022009637 putative Mg++ binding site [ion binding]; other site 412022009638 nucleotide binding region [chemical binding]; other site 412022009639 helicase superfamily c-terminal domain; Region: HELICc; smart00490 412022009640 ATP-binding site [chemical binding]; other site 412022009641 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 412022009642 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 412022009643 substrate binding site [chemical binding]; other site 412022009644 active site 412022009645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022009646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022009647 substrate binding pocket [chemical binding]; other site 412022009648 membrane-bound complex binding site; other site 412022009649 hinge residues; other site 412022009650 CoA binding domain; Region: CoA_binding; cl17356 412022009651 AMP-binding domain protein; Validated; Region: PRK08315 412022009652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022009653 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 412022009654 acyl-activating enzyme (AAE) consensus motif; other site 412022009655 putative AMP binding site [chemical binding]; other site 412022009656 putative active site [active] 412022009657 putative CoA binding site [chemical binding]; other site 412022009658 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009660 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009661 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 412022009662 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 412022009663 gamma subunit interface [polypeptide binding]; other site 412022009664 epsilon subunit interface [polypeptide binding]; other site 412022009665 LBP interface [polypeptide binding]; other site 412022009666 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 412022009667 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412022009668 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 412022009669 alpha subunit interaction interface [polypeptide binding]; other site 412022009670 Walker A motif; other site 412022009671 ATP binding site [chemical binding]; other site 412022009672 Walker B motif; other site 412022009673 inhibitor binding site; inhibition site 412022009674 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412022009675 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 412022009676 core domain interface [polypeptide binding]; other site 412022009677 delta subunit interface [polypeptide binding]; other site 412022009678 epsilon subunit interface [polypeptide binding]; other site 412022009679 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 412022009680 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412022009681 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 412022009682 beta subunit interaction interface [polypeptide binding]; other site 412022009683 Walker A motif; other site 412022009684 ATP binding site [chemical binding]; other site 412022009685 Walker B motif; other site 412022009686 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412022009687 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 412022009688 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 412022009689 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 412022009690 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 412022009691 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 412022009692 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 412022009693 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 412022009694 ATP synthase I chain; Region: ATP_synt_I; cl09170 412022009695 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 412022009696 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412022009697 transmembrane helices; other site 412022009698 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 412022009699 ParB-like nuclease domain; Region: ParBc; pfam02195 412022009700 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412022009701 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412022009702 P-loop; other site 412022009703 Magnesium ion binding site [ion binding]; other site 412022009704 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412022009705 Magnesium ion binding site [ion binding]; other site 412022009706 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 412022009707 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 412022009708 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 412022009709 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 412022009710 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 412022009711 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 412022009712 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412022009713 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412022009714 Walker A/P-loop; other site 412022009715 ATP binding site [chemical binding]; other site 412022009716 Q-loop/lid; other site 412022009717 ABC transporter signature motif; other site 412022009718 Walker B; other site 412022009719 D-loop; other site 412022009720 H-loop/switch region; other site 412022009721 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412022009722 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412022009723 TM-ABC transporter signature motif; other site 412022009724 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412022009725 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412022009726 Walker A/P-loop; other site 412022009727 ATP binding site [chemical binding]; other site 412022009728 Q-loop/lid; other site 412022009729 ABC transporter signature motif; other site 412022009730 Walker B; other site 412022009731 D-loop; other site 412022009732 H-loop/switch region; other site 412022009733 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 412022009734 TM-ABC transporter signature motif; other site 412022009735 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 412022009736 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 412022009737 putative ligand binding site [chemical binding]; other site 412022009738 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412022009739 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412022009740 TM-ABC transporter signature motif; other site 412022009741 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022009742 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 412022009743 TM-ABC transporter signature motif; other site 412022009744 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 412022009745 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 412022009746 putative ligand binding site [chemical binding]; other site 412022009747 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412022009748 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412022009749 Walker A/P-loop; other site 412022009750 ATP binding site [chemical binding]; other site 412022009751 Q-loop/lid; other site 412022009752 ABC transporter signature motif; other site 412022009753 Walker B; other site 412022009754 D-loop; other site 412022009755 H-loop/switch region; other site 412022009756 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412022009757 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412022009758 Walker A/P-loop; other site 412022009759 ATP binding site [chemical binding]; other site 412022009760 Q-loop/lid; other site 412022009761 ABC transporter signature motif; other site 412022009762 Walker B; other site 412022009763 D-loop; other site 412022009764 H-loop/switch region; other site 412022009765 choline dehydrogenase; Validated; Region: PRK02106 412022009766 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 412022009767 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 412022009768 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 412022009769 tetrameric interface [polypeptide binding]; other site 412022009770 NAD binding site [chemical binding]; other site 412022009771 catalytic residues [active] 412022009772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022009773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022009774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022009775 dimerization interface [polypeptide binding]; other site 412022009776 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 412022009777 putative active site [active] 412022009778 putative metal binding residues [ion binding]; other site 412022009779 signature motif; other site 412022009780 putative triphosphate binding site [ion binding]; other site 412022009781 dimer interface [polypeptide binding]; other site 412022009782 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022009783 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 412022009784 putative DNA binding site [nucleotide binding]; other site 412022009785 putative Zn2+ binding site [ion binding]; other site 412022009786 AsnC family; Region: AsnC_trans_reg; pfam01037 412022009787 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 412022009788 cofactor binding site; other site 412022009789 metal binding site [ion binding]; metal-binding site 412022009790 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 412022009791 aromatic arch; other site 412022009792 DCoH dimer interaction site [polypeptide binding]; other site 412022009793 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 412022009794 DCoH tetramer interaction site [polypeptide binding]; other site 412022009795 substrate binding site [chemical binding]; other site 412022009796 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 412022009797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022009798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022009799 active site 412022009800 phosphorylation site [posttranslational modification] 412022009801 intermolecular recognition site; other site 412022009802 dimerization interface [polypeptide binding]; other site 412022009803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022009804 DNA binding site [nucleotide binding] 412022009805 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 412022009806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022009807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022009808 dimer interface [polypeptide binding]; other site 412022009809 phosphorylation site [posttranslational modification] 412022009810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022009811 ATP binding site [chemical binding]; other site 412022009812 Mg2+ binding site [ion binding]; other site 412022009813 G-X-G motif; other site 412022009814 Proteins containing SET domain [General function prediction only]; Region: COG2940 412022009815 SET domain; Region: SET; pfam00856 412022009816 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412022009817 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 412022009818 active site 412022009819 FMN binding site [chemical binding]; other site 412022009820 substrate binding site [chemical binding]; other site 412022009821 homotetramer interface [polypeptide binding]; other site 412022009822 catalytic residue [active] 412022009823 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 412022009824 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 412022009825 catalytic triad [active] 412022009826 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412022009827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022009828 dimerization interface [polypeptide binding]; other site 412022009829 putative DNA binding site [nucleotide binding]; other site 412022009830 putative Zn2+ binding site [ion binding]; other site 412022009831 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 412022009832 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 412022009833 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412022009834 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 412022009835 Uncharacterized conserved protein [Function unknown]; Region: COG4121 412022009836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412022009837 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412022009838 IHF dimer interface [polypeptide binding]; other site 412022009839 IHF - DNA interface [nucleotide binding]; other site 412022009840 Transposase domain (DUF772); Region: DUF772; pfam05598 412022009841 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022009842 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022009843 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 412022009844 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 412022009845 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 412022009846 active site 412022009847 catalytic site [active] 412022009848 substrate binding site [chemical binding]; other site 412022009849 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 412022009850 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022009851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022009852 putative DNA binding site [nucleotide binding]; other site 412022009853 putative Zn2+ binding site [ion binding]; other site 412022009854 AsnC family; Region: AsnC_trans_reg; pfam01037 412022009855 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 412022009856 Cation efflux family; Region: Cation_efflux; pfam01545 412022009857 H-NS histone family; Region: Histone_HNS; pfam00816 412022009858 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022009859 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 412022009860 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 412022009861 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 412022009862 dimerization interface [polypeptide binding]; other site 412022009863 ligand binding site [chemical binding]; other site 412022009864 HTH-like domain; Region: HTH_21; pfam13276 412022009865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022009866 Integrase core domain; Region: rve; pfam00665 412022009867 Integrase core domain; Region: rve_3; pfam13683 412022009868 Transposase; Region: HTH_Tnp_1; pfam01527 412022009869 Chitin binding domain; Region: Chitin_bind_3; pfam03067 412022009870 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412022009871 FAD binding domain; Region: FAD_binding_4; pfam01565 412022009872 Berberine and berberine like; Region: BBE; pfam08031 412022009873 Cache domain; Region: Cache_1; pfam02743 412022009874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022009875 dimerization interface [polypeptide binding]; other site 412022009876 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022009877 putative CheW interface [polypeptide binding]; other site 412022009878 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 412022009879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 412022009880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 412022009881 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 412022009882 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 412022009883 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022009884 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412022009885 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 412022009886 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 412022009887 [2Fe-2S] cluster binding site [ion binding]; other site 412022009888 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 412022009889 alpha subunit interface [polypeptide binding]; other site 412022009890 active site 412022009891 substrate binding site [chemical binding]; other site 412022009892 Fe binding site [ion binding]; other site 412022009893 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 412022009894 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 412022009895 putative trimer interface [polypeptide binding]; other site 412022009896 putative CoA binding site [chemical binding]; other site 412022009897 short chain dehydrogenase; Provisional; Region: PRK06500 412022009898 classical (c) SDRs; Region: SDR_c; cd05233 412022009899 NAD(P) binding site [chemical binding]; other site 412022009900 active site 412022009901 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412022009902 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 412022009903 dimer interface [polypeptide binding]; other site 412022009904 active site 412022009905 CoA binding pocket [chemical binding]; other site 412022009906 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 412022009907 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 412022009908 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412022009909 dimer interface [polypeptide binding]; other site 412022009910 active site 412022009911 CoA binding pocket [chemical binding]; other site 412022009912 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 412022009913 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 412022009914 inhibitor-cofactor binding pocket; inhibition site 412022009915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022009916 catalytic residue [active] 412022009917 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412022009918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022009919 TPR motif; other site 412022009920 binding surface 412022009921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022009922 binding surface 412022009923 TPR motif; other site 412022009924 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 412022009925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022009926 TPR motif; other site 412022009927 binding surface 412022009928 flagellar capping protein; Reviewed; Region: fliD; PRK08032 412022009929 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 412022009930 flagellin; Reviewed; Region: PRK08869 412022009931 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412022009932 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 412022009933 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 412022009934 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 412022009935 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 412022009936 putative hydrolase; Provisional; Region: PRK10976 412022009937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022009938 active site 412022009939 motif I; other site 412022009940 motif II; other site 412022009941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022009942 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 412022009943 amphipathic channel; other site 412022009944 Asn-Pro-Ala signature motifs; other site 412022009945 H-NS histone family; Region: Histone_HNS; pfam00816 412022009946 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 412022009947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022009948 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 412022009949 putative ADP-binding pocket [chemical binding]; other site 412022009950 transcriptional activator FlhD; Provisional; Region: PRK02909 412022009951 transcriptional activator FlhC; Provisional; Region: PRK12722 412022009952 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 412022009953 flagellar motor protein MotA; Validated; Region: PRK09110 412022009954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022009955 ligand binding site [chemical binding]; other site 412022009956 Response regulator receiver domain; Region: Response_reg; pfam00072 412022009957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022009958 active site 412022009959 phosphorylation site [posttranslational modification] 412022009960 intermolecular recognition site; other site 412022009961 dimerization interface [polypeptide binding]; other site 412022009962 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 412022009963 putative binding surface; other site 412022009964 active site 412022009965 CheY binding; Region: CheY-binding; pfam09078 412022009966 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 412022009967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022009968 ATP binding site [chemical binding]; other site 412022009969 Mg2+ binding site [ion binding]; other site 412022009970 G-X-G motif; other site 412022009971 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 412022009972 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 412022009973 putative CheA interaction surface; other site 412022009974 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 412022009975 dimer interface [polypeptide binding]; other site 412022009976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022009977 dimerization interface [polypeptide binding]; other site 412022009978 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412022009979 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022009980 dimer interface [polypeptide binding]; other site 412022009981 putative CheW interface [polypeptide binding]; other site 412022009982 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 412022009983 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 412022009984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022009985 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 412022009986 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 412022009987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022009988 active site 412022009989 phosphorylation site [posttranslational modification] 412022009990 intermolecular recognition site; other site 412022009991 dimerization interface [polypeptide binding]; other site 412022009992 CheB methylesterase; Region: CheB_methylest; pfam01339 412022009993 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 412022009994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022009995 active site 412022009996 phosphorylation site [posttranslational modification] 412022009997 intermolecular recognition site; other site 412022009998 dimerization interface [polypeptide binding]; other site 412022009999 chemotaxis regulator CheZ; Provisional; Region: PRK11166 412022010000 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 412022010001 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 412022010002 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 412022010003 dimer interface [polypeptide binding]; other site 412022010004 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 412022010005 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 412022010006 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 412022010007 FHIPEP family; Region: FHIPEP; pfam00771 412022010008 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 412022010009 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412022010010 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412022010011 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 412022010012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022010013 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412022010014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022010015 DNA binding residues [nucleotide binding] 412022010016 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 412022010017 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 412022010018 homotetramer interface [polypeptide binding]; other site 412022010019 ligand binding site [chemical binding]; other site 412022010020 catalytic site [active] 412022010021 NAD binding site [chemical binding]; other site 412022010022 Predicted membrane protein [Function unknown]; Region: COG1950 412022010023 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 412022010024 FAD binding site [chemical binding]; other site 412022010025 amidase; Provisional; Region: PRK07869 412022010026 Amidase; Region: Amidase; cl11426 412022010027 Dienelactone hydrolase family; Region: DLH; pfam01738 412022010028 Nitronate monooxygenase; Region: NMO; pfam03060 412022010029 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 412022010030 FMN binding site [chemical binding]; other site 412022010031 substrate binding site [chemical binding]; other site 412022010032 putative catalytic residue [active] 412022010033 Transposase; Region: HTH_Tnp_1; pfam01527 412022010034 HTH-like domain; Region: HTH_21; pfam13276 412022010035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010036 Integrase core domain; Region: rve; pfam00665 412022010037 Integrase core domain; Region: rve_3; pfam13683 412022010038 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 412022010039 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 412022010040 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 412022010041 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 412022010042 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 412022010043 Clp amino terminal domain; Region: Clp_N; pfam02861 412022010044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022010045 Walker A motif; other site 412022010046 ATP binding site [chemical binding]; other site 412022010047 Walker B motif; other site 412022010048 arginine finger; other site 412022010049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022010050 Walker A motif; other site 412022010051 ATP binding site [chemical binding]; other site 412022010052 Walker B motif; other site 412022010053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412022010054 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 412022010055 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 412022010056 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 412022010057 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022010058 ligand binding site [chemical binding]; other site 412022010059 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 412022010060 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 412022010061 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 412022010062 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 412022010063 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 412022010064 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 412022010065 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 412022010066 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 412022010067 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 412022010068 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 412022010069 putative active site [active] 412022010070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412022010071 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 412022010072 Walker A/P-loop; other site 412022010073 ATP binding site [chemical binding]; other site 412022010074 Q-loop/lid; other site 412022010075 ABC transporter signature motif; other site 412022010076 Walker B; other site 412022010077 D-loop; other site 412022010078 H-loop/switch region; other site 412022010079 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 412022010080 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022010081 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022010082 Peptidase family M1; Region: Peptidase_M1; pfam01433 412022010083 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412022010084 Zn binding site [ion binding]; other site 412022010085 Water Stress and Hypersensitive response; Region: WHy; smart00769 412022010086 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 412022010087 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 412022010088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022010089 S-adenosylmethionine binding site [chemical binding]; other site 412022010090 Methyltransferase domain; Region: Methyltransf_32; pfam13679 412022010091 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022010092 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 412022010093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022010094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022010095 D-galactonate transporter; Region: 2A0114; TIGR00893 412022010096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022010097 putative substrate translocation pore; other site 412022010098 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 412022010099 putative FMN binding site [chemical binding]; other site 412022010100 putative chaperone; Provisional; Region: PRK11678 412022010101 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 412022010102 nucleotide binding site [chemical binding]; other site 412022010103 putative NEF/HSP70 interaction site [polypeptide binding]; other site 412022010104 SBD interface [polypeptide binding]; other site 412022010105 Transposase domain (DUF772); Region: DUF772; pfam05598 412022010106 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022010107 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022010108 Predicted methyltransferases [General function prediction only]; Region: COG0313 412022010109 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 412022010110 putative SAM binding site [chemical binding]; other site 412022010111 putative homodimer interface [polypeptide binding]; other site 412022010112 hypothetical protein; Provisional; Region: PRK14673 412022010113 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 412022010114 dimer interface [polypeptide binding]; other site 412022010115 active site 412022010116 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 412022010117 BON domain; Region: BON; pfam04972 412022010118 BON domain; Region: BON; pfam04972 412022010119 Cytochrome c; Region: Cytochrom_C; cl11414 412022010120 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 412022010121 HTH-like domain; Region: HTH_21; pfam13276 412022010122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010123 Integrase core domain; Region: rve; pfam00665 412022010124 Integrase core domain; Region: rve_3; pfam13683 412022010125 Transposase; Region: HTH_Tnp_1; pfam01527 412022010126 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412022010127 DNA-binding site [nucleotide binding]; DNA binding site 412022010128 RNA-binding motif; other site 412022010129 Transposase domain (DUF772); Region: DUF772; pfam05598 412022010130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022010131 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022010132 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 412022010133 Transglycosylase; Region: Transgly; pfam00912 412022010134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412022010135 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 412022010136 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 412022010137 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022010138 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022010139 shikimate kinase; Reviewed; Region: aroK; PRK00131 412022010140 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 412022010141 ADP binding site [chemical binding]; other site 412022010142 magnesium binding site [ion binding]; other site 412022010143 putative shikimate binding site; other site 412022010144 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 412022010145 active site 412022010146 dimer interface [polypeptide binding]; other site 412022010147 metal binding site [ion binding]; metal-binding site 412022010148 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 412022010149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412022010150 Zn2+ binding site [ion binding]; other site 412022010151 Mg2+ binding site [ion binding]; other site 412022010152 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 412022010153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 412022010154 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 412022010155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022010156 dimer interface [polypeptide binding]; other site 412022010157 conserved gate region; other site 412022010158 putative PBP binding loops; other site 412022010159 ABC-ATPase subunit interface; other site 412022010160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 412022010161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022010162 dimer interface [polypeptide binding]; other site 412022010163 conserved gate region; other site 412022010164 putative PBP binding loops; other site 412022010165 ABC-ATPase subunit interface; other site 412022010166 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 412022010167 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 412022010168 Walker A/P-loop; other site 412022010169 ATP binding site [chemical binding]; other site 412022010170 Q-loop/lid; other site 412022010171 ABC transporter signature motif; other site 412022010172 Walker B; other site 412022010173 D-loop; other site 412022010174 H-loop/switch region; other site 412022010175 TOBE domain; Region: TOBE_2; pfam08402 412022010176 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 412022010177 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 412022010178 active site 412022010179 catalytic site [active] 412022010180 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 412022010181 Transposase IS200 like; Region: Y1_Tnp; cl00848 412022010182 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 412022010183 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 412022010184 active site 412022010185 dimer interface [polypeptide binding]; other site 412022010186 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 412022010187 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 412022010188 active site 412022010189 FMN binding site [chemical binding]; other site 412022010190 substrate binding site [chemical binding]; other site 412022010191 3Fe-4S cluster binding site [ion binding]; other site 412022010192 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 412022010193 domain interface; other site 412022010194 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 412022010195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022010196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022010197 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412022010198 amino acid carrier protein; Region: agcS; TIGR00835 412022010199 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 412022010200 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 412022010201 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 412022010202 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 412022010203 FAD dependent oxidoreductase; Region: DAO; pfam01266 412022010204 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 412022010205 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 412022010206 thiS-thiF/thiG interaction site; other site 412022010207 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 412022010208 ThiS interaction site; other site 412022010209 putative active site [active] 412022010210 tetramer interface [polypeptide binding]; other site 412022010211 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412022010212 thiamine phosphate binding site [chemical binding]; other site 412022010213 active site 412022010214 pyrophosphate binding site [ion binding]; other site 412022010215 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 412022010216 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 412022010217 Walker A/P-loop; other site 412022010218 ATP binding site [chemical binding]; other site 412022010219 Q-loop/lid; other site 412022010220 ABC transporter signature motif; other site 412022010221 Walker B; other site 412022010222 D-loop; other site 412022010223 H-loop/switch region; other site 412022010224 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 412022010225 Permease; Region: Permease; pfam02405 412022010226 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 412022010227 mce related protein; Region: MCE; pfam02470 412022010228 VacJ like lipoprotein; Region: VacJ; cl01073 412022010229 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 412022010230 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 412022010231 anti sigma factor interaction site; other site 412022010232 regulatory phosphorylation site [posttranslational modification]; other site 412022010233 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412022010234 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412022010235 Walker A/P-loop; other site 412022010236 ATP binding site [chemical binding]; other site 412022010237 Q-loop/lid; other site 412022010238 ABC transporter signature motif; other site 412022010239 Walker B; other site 412022010240 D-loop; other site 412022010241 H-loop/switch region; other site 412022010242 ABC-2 type transporter; Region: ABC2_membrane; cl17235 412022010243 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 412022010244 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 412022010245 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412022010246 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 412022010247 hinge; other site 412022010248 active site 412022010249 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 412022010250 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 412022010251 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 412022010252 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 412022010253 NAD binding site [chemical binding]; other site 412022010254 dimerization interface [polypeptide binding]; other site 412022010255 product binding site; other site 412022010256 substrate binding site [chemical binding]; other site 412022010257 zinc binding site [ion binding]; other site 412022010258 catalytic residues [active] 412022010259 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 412022010260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022010261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022010262 homodimer interface [polypeptide binding]; other site 412022010263 catalytic residue [active] 412022010264 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 412022010265 putative active site pocket [active] 412022010266 4-fold oligomerization interface [polypeptide binding]; other site 412022010267 metal binding residues [ion binding]; metal-binding site 412022010268 3-fold/trimer interface [polypeptide binding]; other site 412022010269 MarC family integral membrane protein; Region: MarC; cl00919 412022010270 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 412022010271 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 412022010272 putative active site [active] 412022010273 oxyanion strand; other site 412022010274 catalytic triad [active] 412022010275 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 412022010276 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 412022010277 catalytic residues [active] 412022010278 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 412022010279 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 412022010280 substrate binding site [chemical binding]; other site 412022010281 glutamase interaction surface [polypeptide binding]; other site 412022010282 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 412022010283 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 412022010284 metal binding site [ion binding]; metal-binding site 412022010285 Predicted membrane protein [Function unknown]; Region: COG3671 412022010286 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 412022010287 nucleotide binding site/active site [active] 412022010288 HIT family signature motif; other site 412022010289 catalytic residue [active] 412022010290 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 412022010291 sec-independent translocase; Provisional; Region: tatB; PRK01919 412022010292 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 412022010293 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 412022010294 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412022010295 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022010296 protein binding site [polypeptide binding]; other site 412022010297 Uncharacterized conserved protein [Function unknown]; Region: COG0327 412022010298 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 412022010299 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 412022010300 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 412022010301 [2Fe-2S] cluster binding site [ion binding]; other site 412022010302 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 412022010303 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 412022010304 Qi binding site; other site 412022010305 intrachain domain interface; other site 412022010306 interchain domain interface [polypeptide binding]; other site 412022010307 heme bH binding site [chemical binding]; other site 412022010308 heme bL binding site [chemical binding]; other site 412022010309 Qo binding site; other site 412022010310 interchain domain interface [polypeptide binding]; other site 412022010311 intrachain domain interface; other site 412022010312 Qi binding site; other site 412022010313 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 412022010314 Qo binding site; other site 412022010315 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 412022010316 stringent starvation protein A; Provisional; Region: sspA; PRK09481 412022010317 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 412022010318 C-terminal domain interface [polypeptide binding]; other site 412022010319 putative GSH binding site (G-site) [chemical binding]; other site 412022010320 dimer interface [polypeptide binding]; other site 412022010321 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 412022010322 dimer interface [polypeptide binding]; other site 412022010323 N-terminal domain interface [polypeptide binding]; other site 412022010324 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 412022010325 portal vertex protein; Provisional; Region: Q; PHA02536 412022010326 Phage portal protein; Region: Phage_portal; pfam04860 412022010327 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 412022010328 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 412022010329 Transposase; Region: HTH_Tnp_1; pfam01527 412022010330 HTH-like domain; Region: HTH_21; pfam13276 412022010331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010332 Integrase core domain; Region: rve; pfam00665 412022010333 Integrase core domain; Region: rve_3; pfam13683 412022010334 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 412022010335 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022010336 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022010337 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 412022010338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022010339 substrate binding site [chemical binding]; other site 412022010340 oxyanion hole (OAH) forming residues; other site 412022010341 trimer interface [polypeptide binding]; other site 412022010342 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412022010343 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022010344 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 412022010345 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022010346 dimer interface [polypeptide binding]; other site 412022010347 active site 412022010348 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022010349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022010350 active site 412022010351 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 412022010352 conserved cys residue [active] 412022010353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022010354 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 412022010355 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 412022010356 Fatty acid desaturase; Region: FA_desaturase; pfam00487 412022010357 putative di-iron ligands [ion binding]; other site 412022010358 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 412022010359 Predicted membrane protein [Function unknown]; Region: COG4709 412022010360 Predicted transcriptional regulators [Transcription]; Region: COG1695 412022010361 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 412022010362 choline dehydrogenase; Validated; Region: PRK02106 412022010363 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 412022010364 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 412022010365 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 412022010366 classical (c) SDRs; Region: SDR_c; cd05233 412022010367 NAD(P) binding site [chemical binding]; other site 412022010368 active site 412022010369 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 412022010370 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 412022010371 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412022010372 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022010373 NAD(P) binding site [chemical binding]; other site 412022010374 catalytic residues [active] 412022010375 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 412022010376 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 412022010377 putative ligand binding site [chemical binding]; other site 412022010378 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 412022010379 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022010380 TM-ABC transporter signature motif; other site 412022010381 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412022010382 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412022010383 TM-ABC transporter signature motif; other site 412022010384 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412022010385 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412022010386 Walker A/P-loop; other site 412022010387 ATP binding site [chemical binding]; other site 412022010388 Q-loop/lid; other site 412022010389 ABC transporter signature motif; other site 412022010390 Walker B; other site 412022010391 D-loop; other site 412022010392 H-loop/switch region; other site 412022010393 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412022010394 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412022010395 Walker A/P-loop; other site 412022010396 ATP binding site [chemical binding]; other site 412022010397 Q-loop/lid; other site 412022010398 ABC transporter signature motif; other site 412022010399 Walker B; other site 412022010400 D-loop; other site 412022010401 H-loop/switch region; other site 412022010402 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 412022010403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022010404 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022010405 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022010406 trimer interface [polypeptide binding]; other site 412022010407 eyelet of channel; other site 412022010408 Restriction endonuclease [Defense mechanisms]; Region: COG3587 412022010409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022010410 ATP binding site [chemical binding]; other site 412022010411 putative Mg++ binding site [ion binding]; other site 412022010412 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 412022010413 DNA methylase; Region: N6_N4_Mtase; pfam01555 412022010414 DNA methylase; Region: N6_N4_Mtase; cl17433 412022010415 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022010416 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022010417 trimer interface [polypeptide binding]; other site 412022010418 eyelet of channel; other site 412022010419 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 412022010420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022010421 active site 412022010422 phosphorylation site [posttranslational modification] 412022010423 intermolecular recognition site; other site 412022010424 dimerization interface [polypeptide binding]; other site 412022010425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022010426 DNA binding site [nucleotide binding] 412022010427 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 412022010428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022010429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022010430 dimer interface [polypeptide binding]; other site 412022010431 phosphorylation site [posttranslational modification] 412022010432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022010433 ATP binding site [chemical binding]; other site 412022010434 Mg2+ binding site [ion binding]; other site 412022010435 G-X-G motif; other site 412022010436 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412022010437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022010438 dimer interface [polypeptide binding]; other site 412022010439 conserved gate region; other site 412022010440 putative PBP binding loops; other site 412022010441 ABC-ATPase subunit interface; other site 412022010442 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412022010443 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412022010444 Walker A/P-loop; other site 412022010445 ATP binding site [chemical binding]; other site 412022010446 Q-loop/lid; other site 412022010447 ABC transporter signature motif; other site 412022010448 Walker B; other site 412022010449 D-loop; other site 412022010450 H-loop/switch region; other site 412022010451 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 412022010452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022010453 membrane-bound complex binding site; other site 412022010454 hinge residues; other site 412022010455 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 412022010456 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022010457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022010458 S-adenosylmethionine binding site [chemical binding]; other site 412022010459 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 412022010460 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 412022010461 DNA binding residues [nucleotide binding] 412022010462 putative dimer interface [polypeptide binding]; other site 412022010463 putative metal binding residues [ion binding]; other site 412022010464 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 412022010465 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 412022010466 HTH-like domain; Region: HTH_21; pfam13276 412022010467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010468 Integrase core domain; Region: rve; pfam00665 412022010469 Integrase core domain; Region: rve_3; pfam13683 412022010470 Transposase; Region: HTH_Tnp_1; pfam01527 412022010471 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 412022010472 flagellar motor switch protein; Validated; Region: fliN; PRK05698 412022010473 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 412022010474 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 412022010475 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 412022010476 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 412022010477 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 412022010478 LrgB-like family; Region: LrgB; cl00596 412022010479 LrgA family; Region: LrgA; pfam03788 412022010480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022010481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022010482 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 412022010483 putative dimerization interface [polypeptide binding]; other site 412022010484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 412022010485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022010486 putative substrate translocation pore; other site 412022010487 MarR family; Region: MarR_2; cl17246 412022010488 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022010489 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 412022010490 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 412022010491 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 412022010492 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 412022010493 GspL periplasmic domain; Region: GspL_C; pfam12693 412022010494 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 412022010495 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 412022010496 type II secretion system protein I; Region: gspI; TIGR01707 412022010497 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 412022010498 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 412022010499 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 412022010500 Type II transport protein GspH; Region: GspH; pfam12019 412022010501 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 412022010502 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 412022010503 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 412022010504 type II secretion system protein F; Region: GspF; TIGR02120 412022010505 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022010506 Ceramidase; Region: Ceramidase; pfam05875 412022010507 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412022010508 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 412022010509 type II secretion system protein E; Region: type_II_gspE; TIGR02533 412022010510 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 412022010511 Walker A motif; other site 412022010512 ATP binding site [chemical binding]; other site 412022010513 Walker B motif; other site 412022010514 type II secretion system protein D; Region: type_II_gspD; TIGR02517 412022010515 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022010516 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022010517 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 412022010518 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 412022010519 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 412022010520 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 412022010521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412022010522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412022010523 catalytic residue [active] 412022010524 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 412022010525 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 412022010526 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 412022010527 Transposase domain (DUF772); Region: DUF772; pfam05598 412022010528 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022010529 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022010530 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 412022010531 putative iron binding site [ion binding]; other site 412022010532 diaminopimelate decarboxylase; Region: lysA; TIGR01048 412022010533 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 412022010534 active site 412022010535 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022010536 substrate binding site [chemical binding]; other site 412022010537 catalytic residues [active] 412022010538 dimer interface [polypeptide binding]; other site 412022010539 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 412022010540 TMAO/DMSO reductase; Reviewed; Region: PRK05363 412022010541 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 412022010542 Moco binding site; other site 412022010543 metal coordination site [ion binding]; other site 412022010544 HTH-like domain; Region: HTH_21; pfam13276 412022010545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010546 Integrase core domain; Region: rve; pfam00665 412022010547 Integrase core domain; Region: rve_3; pfam13683 412022010548 Transposase; Region: HTH_Tnp_1; pfam01527 412022010549 elongation factor Tu; Reviewed; Region: PRK00049 412022010550 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412022010551 G1 box; other site 412022010552 GEF interaction site [polypeptide binding]; other site 412022010553 GTP/Mg2+ binding site [chemical binding]; other site 412022010554 Switch I region; other site 412022010555 G2 box; other site 412022010556 G3 box; other site 412022010557 Switch II region; other site 412022010558 G4 box; other site 412022010559 G5 box; other site 412022010560 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412022010561 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412022010562 Antibiotic Binding Site [chemical binding]; other site 412022010563 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 412022010564 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 412022010565 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 412022010566 putative homodimer interface [polypeptide binding]; other site 412022010567 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 412022010568 heterodimer interface [polypeptide binding]; other site 412022010569 homodimer interface [polypeptide binding]; other site 412022010570 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 412022010571 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 412022010572 23S rRNA interface [nucleotide binding]; other site 412022010573 L7/L12 interface [polypeptide binding]; other site 412022010574 putative thiostrepton binding site; other site 412022010575 L25 interface [polypeptide binding]; other site 412022010576 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 412022010577 mRNA/rRNA interface [nucleotide binding]; other site 412022010578 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 412022010579 23S rRNA interface [nucleotide binding]; other site 412022010580 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 412022010581 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 412022010582 peripheral dimer interface [polypeptide binding]; other site 412022010583 core dimer interface [polypeptide binding]; other site 412022010584 L10 interface [polypeptide binding]; other site 412022010585 L11 interface [polypeptide binding]; other site 412022010586 putative EF-Tu interaction site [polypeptide binding]; other site 412022010587 putative EF-G interaction site [polypeptide binding]; other site 412022010588 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 412022010589 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 412022010590 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 412022010591 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412022010592 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 412022010593 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412022010594 RPB3 interaction site [polypeptide binding]; other site 412022010595 RPB1 interaction site [polypeptide binding]; other site 412022010596 RPB11 interaction site [polypeptide binding]; other site 412022010597 RPB10 interaction site [polypeptide binding]; other site 412022010598 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 412022010599 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 412022010600 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 412022010601 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 412022010602 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 412022010603 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412022010604 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 412022010605 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 412022010606 DNA binding site [nucleotide binding] 412022010607 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 412022010608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022010609 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022010610 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 412022010611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022010612 ATP binding site [chemical binding]; other site 412022010613 putative Mg++ binding site [ion binding]; other site 412022010614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022010615 nucleotide binding region [chemical binding]; other site 412022010616 ATP-binding site [chemical binding]; other site 412022010617 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 412022010618 HRDC domain; Region: HRDC; pfam00570 412022010619 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 412022010620 S17 interaction site [polypeptide binding]; other site 412022010621 S8 interaction site; other site 412022010622 16S rRNA interaction site [nucleotide binding]; other site 412022010623 streptomycin interaction site [chemical binding]; other site 412022010624 23S rRNA interaction site [nucleotide binding]; other site 412022010625 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 412022010626 30S ribosomal protein S7; Validated; Region: PRK05302 412022010627 elongation factor G; Reviewed; Region: PRK00007 412022010628 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 412022010629 G1 box; other site 412022010630 putative GEF interaction site [polypeptide binding]; other site 412022010631 GTP/Mg2+ binding site [chemical binding]; other site 412022010632 Switch I region; other site 412022010633 G2 box; other site 412022010634 G3 box; other site 412022010635 Switch II region; other site 412022010636 G4 box; other site 412022010637 G5 box; other site 412022010638 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 412022010639 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 412022010640 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 412022010641 elongation factor Tu; Reviewed; Region: PRK00049 412022010642 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412022010643 G1 box; other site 412022010644 GEF interaction site [polypeptide binding]; other site 412022010645 GTP/Mg2+ binding site [chemical binding]; other site 412022010646 Switch I region; other site 412022010647 G2 box; other site 412022010648 G3 box; other site 412022010649 Switch II region; other site 412022010650 G4 box; other site 412022010651 G5 box; other site 412022010652 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412022010653 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412022010654 Antibiotic Binding Site [chemical binding]; other site 412022010655 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 412022010656 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 412022010657 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 412022010658 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 412022010659 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 412022010660 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 412022010661 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 412022010662 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 412022010663 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 412022010664 putative translocon binding site; other site 412022010665 protein-rRNA interface [nucleotide binding]; other site 412022010666 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 412022010667 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 412022010668 G-X-X-G motif; other site 412022010669 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 412022010670 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 412022010671 23S rRNA interface [nucleotide binding]; other site 412022010672 5S rRNA interface [nucleotide binding]; other site 412022010673 putative antibiotic binding site [chemical binding]; other site 412022010674 L25 interface [polypeptide binding]; other site 412022010675 L27 interface [polypeptide binding]; other site 412022010676 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 412022010677 23S rRNA interface [nucleotide binding]; other site 412022010678 putative translocon interaction site; other site 412022010679 signal recognition particle (SRP54) interaction site; other site 412022010680 L23 interface [polypeptide binding]; other site 412022010681 trigger factor interaction site; other site 412022010682 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 412022010683 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 412022010684 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 412022010685 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 412022010686 RNA binding site [nucleotide binding]; other site 412022010687 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 412022010688 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 412022010689 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 412022010690 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 412022010691 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 412022010692 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 412022010693 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412022010694 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412022010695 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 412022010696 5S rRNA interface [nucleotide binding]; other site 412022010697 L27 interface [polypeptide binding]; other site 412022010698 23S rRNA interface [nucleotide binding]; other site 412022010699 L5 interface [polypeptide binding]; other site 412022010700 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 412022010701 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 412022010702 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 412022010703 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 412022010704 23S rRNA binding site [nucleotide binding]; other site 412022010705 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 412022010706 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 412022010707 SecY translocase; Region: SecY; pfam00344 412022010708 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 412022010709 rRNA binding site [nucleotide binding]; other site 412022010710 predicted 30S ribosome binding site; other site 412022010711 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 412022010712 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 412022010713 30S ribosomal protein S13; Region: bact_S13; TIGR03631 412022010714 30S ribosomal protein S11; Validated; Region: PRK05309 412022010715 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 412022010716 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 412022010717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022010718 RNA binding surface [nucleotide binding]; other site 412022010719 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 412022010720 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 412022010721 alphaNTD homodimer interface [polypeptide binding]; other site 412022010722 alphaNTD - beta interaction site [polypeptide binding]; other site 412022010723 alphaNTD - beta' interaction site [polypeptide binding]; other site 412022010724 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 412022010725 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 412022010726 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 412022010727 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 412022010728 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 412022010729 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 412022010730 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 412022010731 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412022010732 DsbD alpha interface [polypeptide binding]; other site 412022010733 catalytic residues [active] 412022010734 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 412022010735 dimer interface [polypeptide binding]; other site 412022010736 active site 412022010737 aspartate-rich active site metal binding site; other site 412022010738 allosteric magnesium binding site [ion binding]; other site 412022010739 Schiff base residues; other site 412022010740 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 412022010741 G1 box; other site 412022010742 GTP/Mg2+ binding site [chemical binding]; other site 412022010743 Switch I region; other site 412022010744 G2 box; other site 412022010745 G3 box; other site 412022010746 Switch II region; other site 412022010747 G4 box; other site 412022010748 G5 box; other site 412022010749 Cytochrome c553 [Energy production and conversion]; Region: COG2863 412022010750 Cytochrome c; Region: Cytochrom_C; cl11414 412022010751 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 412022010752 ResB-like family; Region: ResB; pfam05140 412022010753 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 412022010754 ResB-like family; Region: ResB; pfam05140 412022010755 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 412022010756 Transposase; Region: HTH_Tnp_1; pfam01527 412022010757 HTH-like domain; Region: HTH_21; pfam13276 412022010758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010759 Integrase core domain; Region: rve; pfam00665 412022010760 Integrase core domain; Region: rve_3; pfam13683 412022010761 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 412022010762 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 412022010763 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 412022010764 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 412022010765 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412022010766 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 412022010767 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412022010768 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 412022010769 substrate binding site [chemical binding]; other site 412022010770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022010771 active site 412022010772 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 412022010773 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412022010774 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 412022010775 putative NAD(P) binding site [chemical binding]; other site 412022010776 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 412022010777 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 412022010778 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 412022010779 dimer interface [polypeptide binding]; other site 412022010780 PYR/PP interface [polypeptide binding]; other site 412022010781 TPP binding site [chemical binding]; other site 412022010782 substrate binding site [chemical binding]; other site 412022010783 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 412022010784 TPP-binding site; other site 412022010785 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 412022010786 Transposase domain (DUF772); Region: DUF772; pfam05598 412022010787 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022010788 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022010789 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 412022010790 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 412022010791 dimer interface [polypeptide binding]; other site 412022010792 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 412022010793 active site 412022010794 Fe binding site [ion binding]; other site 412022010795 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022010796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022010797 putative DNA binding site [nucleotide binding]; other site 412022010798 putative Zn2+ binding site [ion binding]; other site 412022010799 AsnC family; Region: AsnC_trans_reg; pfam01037 412022010800 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412022010801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022010802 Coenzyme A binding pocket [chemical binding]; other site 412022010803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022010804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022010805 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 412022010806 Protein of unknown function; Region: DUF3658; pfam12395 412022010807 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 412022010808 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 412022010809 FAD binding pocket [chemical binding]; other site 412022010810 FAD binding motif [chemical binding]; other site 412022010811 phosphate binding motif [ion binding]; other site 412022010812 beta-alpha-beta structure motif; other site 412022010813 NAD(p) ribose binding residues [chemical binding]; other site 412022010814 NAD binding pocket [chemical binding]; other site 412022010815 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 412022010816 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022010817 catalytic loop [active] 412022010818 iron binding site [ion binding]; other site 412022010819 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 412022010820 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 412022010821 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 412022010822 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 412022010823 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 412022010824 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 412022010825 active site 412022010826 catalytic triad [active] 412022010827 oxyanion hole [active] 412022010828 Transposase; Region: HTH_Tnp_1; pfam01527 412022010829 HTH-like domain; Region: HTH_21; pfam13276 412022010830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010831 Integrase core domain; Region: rve; pfam00665 412022010832 Integrase core domain; Region: rve_3; pfam13683 412022010833 Transposase domain (DUF772); Region: DUF772; pfam05598 412022010834 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022010835 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022010836 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 412022010837 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 412022010838 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 412022010839 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 412022010840 active site 412022010841 HIGH motif; other site 412022010842 KMSK motif region; other site 412022010843 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412022010844 tRNA binding surface [nucleotide binding]; other site 412022010845 anticodon binding site; other site 412022010846 Sporulation related domain; Region: SPOR; pfam05036 412022010847 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 412022010848 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 412022010849 catalytic residues [active] 412022010850 hinge region; other site 412022010851 alpha helical domain; other site 412022010852 short chain dehydrogenase; Provisional; Region: PRK07024 412022010853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022010854 NAD(P) binding site [chemical binding]; other site 412022010855 active site 412022010856 short chain dehydrogenase; Validated; Region: PRK08264 412022010857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022010858 NAD(P) binding site [chemical binding]; other site 412022010859 active site 412022010860 MarR family; Region: MarR_2; cl17246 412022010861 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412022010862 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 412022010863 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 412022010864 peptide binding site [polypeptide binding]; other site 412022010865 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412022010866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022010867 Walker A/P-loop; other site 412022010868 ATP binding site [chemical binding]; other site 412022010869 Q-loop/lid; other site 412022010870 ABC transporter signature motif; other site 412022010871 Walker B; other site 412022010872 D-loop; other site 412022010873 H-loop/switch region; other site 412022010874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022010875 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 412022010876 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 412022010877 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 412022010878 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 412022010879 active site clefts [active] 412022010880 zinc binding site [ion binding]; other site 412022010881 dimer interface [polypeptide binding]; other site 412022010882 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 412022010883 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022010884 dimer interface [polypeptide binding]; other site 412022010885 active site 412022010886 short chain dehydrogenase; Provisional; Region: PRK06953 412022010887 NAD(P) binding site [chemical binding]; other site 412022010888 active site 412022010889 hypothetical protein; Provisional; Region: PRK01842 412022010890 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 412022010891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 412022010892 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 412022010893 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022010894 inhibitor-cofactor binding pocket; inhibition site 412022010895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022010896 catalytic residue [active] 412022010897 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 412022010898 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 412022010899 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022010900 catalytic residue [active] 412022010901 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 412022010902 AAA domain; Region: AAA_26; pfam13500 412022010903 biotin synthase; Region: bioB; TIGR00433 412022010904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022010905 FeS/SAM binding site; other site 412022010906 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 412022010907 CutC family; Region: CutC; cl01218 412022010908 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 412022010909 Alkaline phosphatase homologues; Region: alkPPc; smart00098 412022010910 active site 412022010911 dimer interface [polypeptide binding]; other site 412022010912 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 412022010913 dimer interface [polypeptide binding]; other site 412022010914 Alkaline phosphatase homologues; Region: alkPPc; smart00098 412022010915 active site 412022010916 HTH-like domain; Region: HTH_21; pfam13276 412022010917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010918 Integrase core domain; Region: rve; pfam00665 412022010919 Integrase core domain; Region: rve_3; pfam13683 412022010920 Transposase; Region: HTH_Tnp_1; pfam01527 412022010921 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 412022010922 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 412022010923 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 412022010924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022010925 dimer interface [polypeptide binding]; other site 412022010926 putative CheW interface [polypeptide binding]; other site 412022010927 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412022010928 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412022010929 DNA binding site [nucleotide binding] 412022010930 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 412022010931 ligand binding site [chemical binding]; other site 412022010932 dimerization interface [polypeptide binding]; other site 412022010933 dimerization interface [polypeptide binding]; other site 412022010934 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 412022010935 putative active cleft [active] 412022010936 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 412022010937 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412022010938 putative substrate binding site [chemical binding]; other site 412022010939 putative ATP binding site [chemical binding]; other site 412022010940 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 412022010941 Uncharacterized conserved protein [Function unknown]; Region: COG1565 412022010942 short chain dehydrogenase; Provisional; Region: PRK09134 412022010943 Dihydroneopterin aldolase; Region: FolB; smart00905 412022010944 active site 412022010945 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 412022010946 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 412022010947 Ligand Binding Site [chemical binding]; other site 412022010948 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 412022010949 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 412022010950 Substrate binding site; other site 412022010951 Mg++ binding site; other site 412022010952 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 412022010953 active site 412022010954 substrate binding site [chemical binding]; other site 412022010955 CoA binding site [chemical binding]; other site 412022010956 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 412022010957 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 412022010958 glutaminase active site [active] 412022010959 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 412022010960 dimer interface [polypeptide binding]; other site 412022010961 active site 412022010962 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 412022010963 dimer interface [polypeptide binding]; other site 412022010964 active site 412022010965 Avidin family; Region: Avidin; pfam01382 412022010966 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 412022010967 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 412022010968 HlyD family secretion protein; Region: HlyD_2; pfam12700 412022010969 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022010970 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 412022010971 Repair protein; Region: Repair_PSII; pfam04536 412022010972 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 412022010973 Repair protein; Region: Repair_PSII; pfam04536 412022010974 LemA family; Region: LemA; pfam04011 412022010975 YHS domain; Region: YHS; pfam04945 412022010976 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412022010977 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412022010978 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412022010979 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 412022010980 metal-binding site [ion binding] 412022010981 argininosuccinate synthase; Validated; Region: PRK05370 412022010982 argininosuccinate synthase; Provisional; Region: PRK13820 412022010983 glutathione reductase; Validated; Region: PRK06116 412022010984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022010985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022010986 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412022010987 Transposase domain (DUF772); Region: DUF772; pfam05598 412022010988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022010989 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022010990 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 412022010991 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 412022010992 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 412022010993 Transposase; Region: HTH_Tnp_1; pfam01527 412022010994 HTH-like domain; Region: HTH_21; pfam13276 412022010995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022010996 Integrase core domain; Region: rve; pfam00665 412022010997 Integrase core domain; Region: rve_3; pfam13683 412022010998 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 412022010999 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 412022011000 ligand binding site; other site 412022011001 putative membrane protein; Region: HpnL; TIGR03476 412022011002 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022011003 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022011004 trimer interface [polypeptide binding]; other site 412022011005 eyelet of channel; other site 412022011006 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 412022011007 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 412022011008 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 412022011009 PhnA protein; Region: PhnA; pfam03831 412022011010 Chromate transporter; Region: Chromate_transp; pfam02417 412022011011 Chromate transporter; Region: Chromate_transp; pfam02417 412022011012 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 412022011013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022011014 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 412022011015 dimerization interface [polypeptide binding]; other site 412022011016 substrate binding pocket [chemical binding]; other site 412022011017 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 412022011018 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 412022011019 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412022011020 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 412022011021 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412022011022 Flagellar regulator YcgR; Region: YcgR; pfam07317 412022011023 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 412022011024 PilZ domain; Region: PilZ; pfam07238 412022011025 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 412022011026 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 412022011027 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 412022011028 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 412022011029 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 412022011030 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 412022011031 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 412022011032 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 412022011033 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412022011034 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412022011035 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 412022011036 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412022011037 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 412022011038 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 412022011039 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412022011040 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 412022011041 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412022011042 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 412022011043 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 412022011044 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 412022011045 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 412022011046 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412022011047 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412022011048 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 412022011049 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 412022011050 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 412022011051 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 412022011052 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 412022011053 FlgN protein; Region: FlgN; pfam05130 412022011054 Killing trait; Region: RebB; pfam11747 412022011055 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 412022011056 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412022011057 active site 412022011058 NTP binding site [chemical binding]; other site 412022011059 metal binding triad [ion binding]; metal-binding site 412022011060 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412022011061 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 412022011062 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412022011063 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 412022011064 putative C-terminal domain interface [polypeptide binding]; other site 412022011065 putative GSH binding site (G-site) [chemical binding]; other site 412022011066 putative dimer interface [polypeptide binding]; other site 412022011067 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 412022011068 putative N-terminal domain interface [polypeptide binding]; other site 412022011069 putative dimer interface [polypeptide binding]; other site 412022011070 putative substrate binding pocket (H-site) [chemical binding]; other site 412022011071 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 412022011072 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 412022011073 putative NAD(P) binding site [chemical binding]; other site 412022011074 active site 412022011075 lytic murein transglycosylase; Provisional; Region: PRK11619 412022011076 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412022011077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412022011078 catalytic residue [active] 412022011079 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 412022011080 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 412022011081 MarR family; Region: MarR_2; cl17246 412022011082 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 412022011083 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 412022011084 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 412022011085 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 412022011086 putative active site [active] 412022011087 Protein of unknown function (DUF969); Region: DUF969; pfam06149 412022011088 Predicted membrane protein [Function unknown]; Region: COG3817 412022011089 Protein of unknown function (DUF979); Region: DUF979; pfam06166 412022011090 TraB family; Region: TraB; pfam01963 412022011091 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 412022011092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022011093 Walker A/P-loop; other site 412022011094 ATP binding site [chemical binding]; other site 412022011095 Q-loop/lid; other site 412022011096 ABC transporter signature motif; other site 412022011097 Walker B; other site 412022011098 D-loop; other site 412022011099 H-loop/switch region; other site 412022011100 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 412022011101 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412022011102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022011103 Walker A/P-loop; other site 412022011104 ATP binding site [chemical binding]; other site 412022011105 Q-loop/lid; other site 412022011106 ABC transporter signature motif; other site 412022011107 Walker B; other site 412022011108 D-loop; other site 412022011109 H-loop/switch region; other site 412022011110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022011111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022011112 dimer interface [polypeptide binding]; other site 412022011113 conserved gate region; other site 412022011114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412022011115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022011116 dimer interface [polypeptide binding]; other site 412022011117 conserved gate region; other site 412022011118 putative PBP binding loops; other site 412022011119 ABC-ATPase subunit interface; other site 412022011120 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 412022011121 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 412022011122 peptide binding site [polypeptide binding]; other site 412022011123 citrate-proton symporter; Provisional; Region: PRK15075 412022011124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011125 putative substrate translocation pore; other site 412022011126 High potential iron-sulfur protein; Region: HIPIP; pfam01355 412022011127 Predicted dehydrogenase [General function prediction only]; Region: COG0579 412022011128 hydroxyglutarate oxidase; Provisional; Region: PRK11728 412022011129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022011130 Walker A motif; other site 412022011131 ATP binding site [chemical binding]; other site 412022011132 Walker B motif; other site 412022011133 arginine finger; other site 412022011134 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 412022011135 putative catalytic site [active] 412022011136 putative phosphate binding site [ion binding]; other site 412022011137 putative metal binding site [ion binding]; other site 412022011138 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022011139 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 412022011140 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 412022011141 FAD binding pocket [chemical binding]; other site 412022011142 FAD binding motif [chemical binding]; other site 412022011143 phosphate binding motif [ion binding]; other site 412022011144 beta-alpha-beta structure motif; other site 412022011145 NAD binding pocket [chemical binding]; other site 412022011146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022011147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022011148 active site 412022011149 phosphorylation site [posttranslational modification] 412022011150 intermolecular recognition site; other site 412022011151 dimerization interface [polypeptide binding]; other site 412022011152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022011153 DNA binding residues [nucleotide binding] 412022011154 dimerization interface [polypeptide binding]; other site 412022011155 amino acid transporter; Region: 2A0306; TIGR00909 412022011156 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 412022011157 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 412022011158 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 412022011159 XdhC Rossmann domain; Region: XdhC_C; pfam13478 412022011160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 412022011161 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 412022011162 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 412022011163 Flagellar protein FliT; Region: FliT; cl05125 412022011164 flagellar protein FliS; Validated; Region: fliS; PRK05685 412022011165 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 412022011166 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 412022011167 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 412022011168 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 412022011169 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 412022011170 FliG C-terminal domain; Region: FliG_C; pfam01706 412022011171 flagellar assembly protein H; Validated; Region: fliH; PRK05687 412022011172 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 412022011173 Flagellar assembly protein FliH; Region: FliH; pfam02108 412022011174 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 412022011175 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 412022011176 Walker A motif/ATP binding site; other site 412022011177 Walker B motif; other site 412022011178 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 412022011179 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 412022011180 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 412022011181 choline dehydrogenase; Validated; Region: PRK02106 412022011182 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 412022011183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022011184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022011185 active site 412022011186 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 412022011187 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 412022011188 NAD(P) binding site [chemical binding]; other site 412022011189 catalytic residues [active] 412022011190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022011191 serine/threonine protein kinase; Provisional; Region: PRK11768 412022011192 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 412022011193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011194 putative substrate translocation pore; other site 412022011195 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412022011196 EamA-like transporter family; Region: EamA; pfam00892 412022011197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412022011198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412022011199 active site 412022011200 catalytic tetrad [active] 412022011201 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 412022011202 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 412022011203 S-adenosylmethionine synthetase; Validated; Region: PRK05250 412022011204 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 412022011205 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 412022011206 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 412022011207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 412022011208 putative acyl-acceptor binding pocket; other site 412022011209 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 412022011210 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412022011211 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412022011212 Protein of unknown function, DUF484; Region: DUF484; cl17449 412022011213 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 412022011214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412022011215 active site 412022011216 DNA binding site [nucleotide binding] 412022011217 Int/Topo IB signature motif; other site 412022011218 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 412022011219 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 412022011220 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 412022011221 putative RNA binding site [nucleotide binding]; other site 412022011222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022011223 S-adenosylmethionine binding site [chemical binding]; other site 412022011224 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 412022011225 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 412022011226 P-loop, Walker A motif; other site 412022011227 Base recognition motif; other site 412022011228 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 412022011229 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 412022011230 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 412022011231 active site 412022011232 HslU subunit interaction site [polypeptide binding]; other site 412022011233 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 412022011234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022011235 Walker A motif; other site 412022011236 ATP binding site [chemical binding]; other site 412022011237 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 412022011238 Walker B motif; other site 412022011239 arginine finger; other site 412022011240 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412022011241 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 412022011242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022011243 active site 412022011244 phosphorylation site [posttranslational modification] 412022011245 intermolecular recognition site; other site 412022011246 dimerization interface [polypeptide binding]; other site 412022011247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022011248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022011249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 412022011250 dimer interface [polypeptide binding]; other site 412022011251 phosphorylation site [posttranslational modification] 412022011252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022011253 ATP binding site [chemical binding]; other site 412022011254 Mg2+ binding site [ion binding]; other site 412022011255 G-X-G motif; other site 412022011256 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 412022011257 feedback inhibition sensing region; other site 412022011258 homohexameric interface [polypeptide binding]; other site 412022011259 nucleotide binding site [chemical binding]; other site 412022011260 N-acetyl-L-glutamate binding site [chemical binding]; other site 412022011261 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 412022011262 division inhibitor protein; Provisional; Region: slmA; PRK09480 412022011263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022011264 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 412022011265 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 412022011266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412022011267 muropeptide transporter; Reviewed; Region: ampG; PRK11902 412022011268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011269 putative substrate translocation pore; other site 412022011270 Peptidase family M48; Region: Peptidase_M48; cl12018 412022011271 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 412022011272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022011273 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022011274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022011275 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022011276 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 412022011277 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 412022011278 putative NAD(P) binding site [chemical binding]; other site 412022011279 putative substrate binding site [chemical binding]; other site 412022011280 catalytic Zn binding site [ion binding]; other site 412022011281 structural Zn binding site [ion binding]; other site 412022011282 dimer interface [polypeptide binding]; other site 412022011283 Transposase domain (DUF772); Region: DUF772; pfam05598 412022011284 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022011285 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022011286 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 412022011287 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 412022011288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022011289 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 412022011290 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 412022011291 SLBB domain; Region: SLBB; pfam10531 412022011292 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 412022011293 Bacterial sugar transferase; Region: Bac_transf; pfam02397 412022011294 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412022011295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 412022011296 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 412022011297 non-specific DNA interactions [nucleotide binding]; other site 412022011298 DNA binding site [nucleotide binding] 412022011299 sequence specific DNA binding site [nucleotide binding]; other site 412022011300 putative cAMP binding site [chemical binding]; other site 412022011301 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412022011302 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412022011303 ligand binding site [chemical binding]; other site 412022011304 flexible hinge region; other site 412022011305 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 412022011306 acyl carrier protein; Provisional; Region: PRK07081 412022011307 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022011308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022011309 active site 412022011310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022011311 active site 412022011312 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 412022011313 dimer interface [polypeptide binding]; other site 412022011314 motif 1; other site 412022011315 active site 412022011316 motif 2; other site 412022011317 motif 3; other site 412022011318 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 412022011319 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 412022011320 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 412022011321 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 412022011322 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022011323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022011324 Walker A motif; other site 412022011325 ATP binding site [chemical binding]; other site 412022011326 Walker B motif; other site 412022011327 arginine finger; other site 412022011328 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 412022011329 active site 412022011330 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022011331 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 412022011332 putative ADP-binding pocket [chemical binding]; other site 412022011333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022011334 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 412022011335 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 412022011336 Substrate binding site; other site 412022011337 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 412022011338 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022011339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022011340 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 412022011341 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 412022011342 PAS domain; Region: PAS; smart00091 412022011343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022011344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022011345 metal binding site [ion binding]; metal-binding site 412022011346 active site 412022011347 I-site; other site 412022011348 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412022011349 aldolase II superfamily protein; Provisional; Region: PRK07044 412022011350 intersubunit interface [polypeptide binding]; other site 412022011351 active site 412022011352 Zn2+ binding site [ion binding]; other site 412022011353 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 412022011354 YcaO-like family; Region: YcaO; pfam02624 412022011355 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 412022011356 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 412022011357 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 412022011358 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 412022011359 active site 412022011360 ATP binding site [chemical binding]; other site 412022011361 substrate binding site [chemical binding]; other site 412022011362 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 412022011363 activation loop (A-loop); other site 412022011364 cyclase homology domain; Region: CHD; cd07302 412022011365 dimer interface [polypeptide binding]; other site 412022011366 nucleotidyl binding site; other site 412022011367 metal binding site [ion binding]; metal-binding site 412022011368 AAA ATPase domain; Region: AAA_16; pfam13191 412022011369 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 412022011370 phosphopeptide binding site; other site 412022011371 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412022011372 Transposase; Region: HTH_Tnp_1; pfam01527 412022011373 HTH-like domain; Region: HTH_21; pfam13276 412022011374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022011375 Integrase core domain; Region: rve; pfam00665 412022011376 Integrase core domain; Region: rve_3; pfam13683 412022011377 Family description; Region: VCBS; pfam13517 412022011378 Family description; Region: VCBS; pfam13517 412022011379 Family description; Region: VCBS; pfam13517 412022011380 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 412022011381 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 412022011382 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 412022011383 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 412022011384 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 412022011385 HTH-like domain; Region: HTH_21; pfam13276 412022011386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022011387 Integrase core domain; Region: rve; pfam00665 412022011388 Integrase core domain; Region: rve_3; pfam13683 412022011389 Transposase; Region: HTH_Tnp_1; pfam01527 412022011390 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 412022011391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022011392 ATP binding site [chemical binding]; other site 412022011393 Mg2+ binding site [ion binding]; other site 412022011394 G-X-G motif; other site 412022011395 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412022011396 anchoring element; other site 412022011397 dimer interface [polypeptide binding]; other site 412022011398 ATP binding site [chemical binding]; other site 412022011399 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 412022011400 active site 412022011401 putative metal-binding site [ion binding]; other site 412022011402 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412022011403 DNA polymerase III subunit beta; Validated; Region: PRK05643 412022011404 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 412022011405 putative DNA binding surface [nucleotide binding]; other site 412022011406 dimer interface [polypeptide binding]; other site 412022011407 beta-clamp/clamp loader binding surface; other site 412022011408 beta-clamp/translesion DNA polymerase binding surface; other site 412022011409 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412022011410 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 412022011411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022011412 Walker A motif; other site 412022011413 ATP binding site [chemical binding]; other site 412022011414 Walker B motif; other site 412022011415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412022011416 arginine finger; other site 412022011417 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 412022011418 DnaA box-binding interface [nucleotide binding]; other site 412022011419 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 412022011420 Ribonuclease P; Region: Ribonuclease_P; cl00457 412022011421 hypothetical protein; Validated; Region: PRK00041 412022011422 membrane protein insertase; Provisional; Region: PRK01318 412022011423 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 412022011424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022011425 sequence-specific DNA binding site [nucleotide binding]; other site 412022011426 salt bridge; other site 412022011427 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 412022011428 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 412022011429 trmE is a tRNA modification GTPase; Region: trmE; cd04164 412022011430 G1 box; other site 412022011431 GTP/Mg2+ binding site [chemical binding]; other site 412022011432 Switch I region; other site 412022011433 G2 box; other site 412022011434 Switch II region; other site 412022011435 G3 box; other site 412022011436 G4 box; other site 412022011437 G5 box; other site 412022011438 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 412022011439 HTH-like domain; Region: HTH_21; pfam13276 412022011440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022011441 Integrase core domain; Region: rve; pfam00665 412022011442 Integrase core domain; Region: rve_3; pfam13683 412022011443 Transposase; Region: HTH_Tnp_1; pfam01527 412022011444 YaeQ protein; Region: YaeQ; pfam07152 412022011445 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 412022011446 dimer interface [polypeptide binding]; other site 412022011447 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022011448 metal binding site [ion binding]; metal-binding site 412022011449 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 412022011450 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 412022011451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022011452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022011453 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 412022011454 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 412022011455 DNA binding site [nucleotide binding] 412022011456 active site 412022011457 AlkA N-terminal domain; Region: AlkA_N; pfam06029 412022011458 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 412022011459 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412022011460 minor groove reading motif; other site 412022011461 helix-hairpin-helix signature motif; other site 412022011462 substrate binding pocket [chemical binding]; other site 412022011463 active site 412022011464 glutamate--cysteine ligase; Provisional; Region: PRK02107 412022011465 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 412022011466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022011467 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412022011468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022011469 DNA binding residues [nucleotide binding] 412022011470 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 412022011471 dimer interface [polypeptide binding]; other site 412022011472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022011473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022011474 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022011475 putative effector binding pocket; other site 412022011476 dimerization interface [polypeptide binding]; other site 412022011477 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 412022011478 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412022011479 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 412022011480 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 412022011481 active site 412022011482 Zn binding site [ion binding]; other site 412022011483 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 412022011484 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 412022011485 putative active site; other site 412022011486 catalytic triad [active] 412022011487 putative dimer interface [polypeptide binding]; other site 412022011488 portal vertex protein; Provisional; Region: Q; PHA02536 412022011489 Phage portal protein; Region: Phage_portal; pfam04860 412022011490 HTH-like domain; Region: HTH_21; pfam13276 412022011491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022011492 Integrase core domain; Region: rve; pfam00665 412022011493 Integrase core domain; Region: rve_3; pfam13683 412022011494 Transposase; Region: HTH_Tnp_1; pfam01527 412022011495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022011496 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022011497 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412022011498 CoenzymeA binding site [chemical binding]; other site 412022011499 subunit interaction site [polypeptide binding]; other site 412022011500 PHB binding site; other site 412022011501 Patatin-like phospholipase; Region: Patatin; pfam01734 412022011502 active site 412022011503 nucleophile elbow; other site 412022011504 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 412022011505 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 412022011506 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 412022011507 dimerization interface [polypeptide binding]; other site 412022011508 NAD binding site [chemical binding]; other site 412022011509 ligand binding site [chemical binding]; other site 412022011510 catalytic site [active] 412022011511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022011512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022011513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022011514 putative effector binding pocket; other site 412022011515 dimerization interface [polypeptide binding]; other site 412022011516 DNA topoisomerase III; Validated; Region: PRK08173 412022011517 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 412022011518 active site 412022011519 putative interdomain interaction site [polypeptide binding]; other site 412022011520 putative metal-binding site [ion binding]; other site 412022011521 putative nucleotide binding site [chemical binding]; other site 412022011522 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412022011523 domain I; other site 412022011524 DNA binding groove [nucleotide binding] 412022011525 phosphate binding site [ion binding]; other site 412022011526 domain II; other site 412022011527 domain III; other site 412022011528 nucleotide binding site [chemical binding]; other site 412022011529 catalytic site [active] 412022011530 domain IV; other site 412022011531 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 412022011532 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 412022011533 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412022011534 catalytic residues [active] 412022011535 DNA protecting protein DprA; Region: dprA; TIGR00732 412022011536 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 412022011537 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412022011538 active site 412022011539 catalytic residues [active] 412022011540 metal binding site [ion binding]; metal-binding site 412022011541 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 412022011542 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 412022011543 putative active site [active] 412022011544 substrate binding site [chemical binding]; other site 412022011545 putative cosubstrate binding site; other site 412022011546 catalytic site [active] 412022011547 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 412022011548 substrate binding site [chemical binding]; other site 412022011549 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022011550 M48 family peptidase; Provisional; Region: PRK03001 412022011551 16S rRNA methyltransferase B; Provisional; Region: PRK10901 412022011552 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 412022011553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022011554 S-adenosylmethionine binding site [chemical binding]; other site 412022011555 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 412022011556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022011557 dimerization interface [polypeptide binding]; other site 412022011558 PAS domain; Region: PAS; smart00091 412022011559 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 412022011560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022011561 dimer interface [polypeptide binding]; other site 412022011562 phosphorylation site [posttranslational modification] 412022011563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022011564 ATP binding site [chemical binding]; other site 412022011565 Mg2+ binding site [ion binding]; other site 412022011566 G-X-G motif; other site 412022011567 Response regulator receiver domain; Region: Response_reg; pfam00072 412022011568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022011569 active site 412022011570 phosphorylation site [posttranslational modification] 412022011571 intermolecular recognition site; other site 412022011572 dimerization interface [polypeptide binding]; other site 412022011573 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 412022011574 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 412022011575 Ligand Binding Site [chemical binding]; other site 412022011576 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 412022011577 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 412022011578 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 412022011579 active site 412022011580 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 412022011581 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412022011582 Sel1 repeat; Region: Sel1; cl02723 412022011583 Sel1-like repeats; Region: SEL1; smart00671 412022011584 Sel1-like repeats; Region: SEL1; smart00671 412022011585 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 412022011586 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412022011587 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412022011588 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412022011589 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 412022011590 rod shape-determining protein MreC; Provisional; Region: PRK13922 412022011591 rod shape-determining protein MreC; Region: MreC; pfam04085 412022011592 rod shape-determining protein MreB; Provisional; Region: PRK13927 412022011593 MreB and similar proteins; Region: MreB_like; cd10225 412022011594 nucleotide binding site [chemical binding]; other site 412022011595 Mg binding site [ion binding]; other site 412022011596 putative protofilament interaction site [polypeptide binding]; other site 412022011597 RodZ interaction site [polypeptide binding]; other site 412022011598 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 412022011599 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 412022011600 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 412022011601 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 412022011602 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 412022011603 GatB domain; Region: GatB_Yqey; smart00845 412022011604 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 412022011605 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 412022011606 putative active site [active] 412022011607 putative catalytic site [active] 412022011608 putative DNA binding site [nucleotide binding]; other site 412022011609 putative phosphate binding site [ion binding]; other site 412022011610 metal binding site A [ion binding]; metal-binding site 412022011611 putative AP binding site [nucleotide binding]; other site 412022011612 putative metal binding site B [ion binding]; other site 412022011613 Transposase domain (DUF772); Region: DUF772; pfam05598 412022011614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022011615 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022011616 CHRD domain; Region: CHRD; pfam07452 412022011617 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 412022011618 EcsC protein family; Region: EcsC; pfam12787 412022011619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022011621 putative substrate translocation pore; other site 412022011622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011623 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412022011624 MarR family; Region: MarR; pfam01047 412022011625 MarR family; Region: MarR_2; cl17246 412022011626 intracellular protease, PfpI family; Region: PfpI; TIGR01382 412022011627 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 412022011628 conserved cys residue [active] 412022011629 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 412022011630 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 412022011631 dimer interface [polypeptide binding]; other site 412022011632 active site 412022011633 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022011634 substrate binding site [chemical binding]; other site 412022011635 catalytic residue [active] 412022011636 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412022011637 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022011638 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412022011639 putative active site [active] 412022011640 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 412022011641 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 412022011642 active site 412022011643 putative substrate binding pocket [chemical binding]; other site 412022011644 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412022011645 homotrimer interaction site [polypeptide binding]; other site 412022011646 putative active site [active] 412022011647 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 412022011648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 412022011649 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 412022011650 threonine dehydratase; Reviewed; Region: PRK09224 412022011651 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412022011652 tetramer interface [polypeptide binding]; other site 412022011653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022011654 catalytic residue [active] 412022011655 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 412022011656 putative Ile/Val binding site [chemical binding]; other site 412022011657 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 412022011658 putative Ile/Val binding site [chemical binding]; other site 412022011659 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 412022011660 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412022011661 FAD binding domain; Region: FAD_binding_4; pfam01565 412022011662 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412022011663 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 412022011664 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412022011665 Cysteine-rich domain; Region: CCG; pfam02754 412022011666 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 412022011667 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 412022011668 nucleotide binding site/active site [active] 412022011669 HIT family signature motif; other site 412022011670 catalytic residue [active] 412022011671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 412022011672 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 412022011673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022011674 S-adenosylmethionine binding site [chemical binding]; other site 412022011675 Tim44-like domain; Region: Tim44; pfam04280 412022011676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 412022011677 SCP-2 sterol transfer family; Region: SCP2; pfam02036 412022011678 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 412022011679 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 412022011680 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 412022011681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412022011682 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 412022011683 Uncharacterized conserved protein [Function unknown]; Region: COG2928 412022011684 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 412022011685 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 412022011686 dimer interface [polypeptide binding]; other site 412022011687 anticodon binding site; other site 412022011688 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 412022011689 homodimer interface [polypeptide binding]; other site 412022011690 motif 1; other site 412022011691 active site 412022011692 motif 2; other site 412022011693 GAD domain; Region: GAD; pfam02938 412022011694 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 412022011695 motif 3; other site 412022011696 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 412022011697 nudix motif; other site 412022011698 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 412022011699 PLD-like domain; Region: PLDc_2; pfam13091 412022011700 putative active site [active] 412022011701 catalytic site [active] 412022011702 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 412022011703 PLD-like domain; Region: PLDc_2; pfam13091 412022011704 putative active site [active] 412022011705 catalytic site [active] 412022011706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022011707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022011708 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 412022011709 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 412022011710 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 412022011711 FAD binding site [chemical binding]; other site 412022011712 substrate binding site [chemical binding]; other site 412022011713 catalytic residues [active] 412022011714 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 412022011715 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 412022011716 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412022011717 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022011718 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 412022011719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022011720 substrate binding site [chemical binding]; other site 412022011721 oxyanion hole (OAH) forming residues; other site 412022011722 trimer interface [polypeptide binding]; other site 412022011723 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 412022011724 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022011725 dimer interface [polypeptide binding]; other site 412022011726 active site 412022011727 enoyl-CoA hydratase; Provisional; Region: PRK06688 412022011728 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022011729 substrate binding site [chemical binding]; other site 412022011730 oxyanion hole (OAH) forming residues; other site 412022011731 trimer interface [polypeptide binding]; other site 412022011732 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 412022011733 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 412022011734 conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664 412022011735 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 412022011736 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 412022011737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412022011738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022011739 Walker A/P-loop; other site 412022011740 ATP binding site [chemical binding]; other site 412022011741 Q-loop/lid; other site 412022011742 ABC transporter signature motif; other site 412022011743 Walker B; other site 412022011744 D-loop; other site 412022011745 H-loop/switch region; other site 412022011746 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 412022011747 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 412022011748 Substrate binding site; other site 412022011749 metal-binding site 412022011750 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 412022011751 Phosphotransferase enzyme family; Region: APH; pfam01636 412022011752 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 412022011753 Organic solvent tolerance protein; Region: OstA_C; pfam04453 412022011754 SurA N-terminal domain; Region: SurA_N; pfam09312 412022011755 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 412022011756 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412022011757 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412022011758 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 412022011759 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 412022011760 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 412022011761 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 412022011762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412022011763 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 412022011764 dimer interface [polypeptide binding]; other site 412022011765 active site 412022011766 metal binding site [ion binding]; metal-binding site 412022011767 glutathione binding site [chemical binding]; other site 412022011768 Protein of unknown function DUF45; Region: DUF45; pfam01863 412022011769 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412022011770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412022011771 putative acyl-acceptor binding pocket; other site 412022011772 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 412022011773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022011774 active site 412022011775 motif I; other site 412022011776 motif II; other site 412022011777 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 412022011778 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 412022011779 dimer interface [polypeptide binding]; other site 412022011780 motif 1; other site 412022011781 active site 412022011782 motif 2; other site 412022011783 motif 3; other site 412022011784 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 412022011785 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 412022011786 putative active site [active] 412022011787 catalytic triad [active] 412022011788 putative dimer interface [polypeptide binding]; other site 412022011789 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 412022011790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412022011791 Transporter associated domain; Region: CorC_HlyC; smart01091 412022011792 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 412022011793 putative active site pocket [active] 412022011794 dimerization interface [polypeptide binding]; other site 412022011795 putative catalytic residue [active] 412022011796 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 412022011797 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 412022011798 PhoH-like protein; Region: PhoH; pfam02562 412022011799 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 412022011800 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 412022011801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022011802 FeS/SAM binding site; other site 412022011803 TRAM domain; Region: TRAM; pfam01938 412022011804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022011805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022011806 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022011807 putative effector binding pocket; other site 412022011808 dimerization interface [polypeptide binding]; other site 412022011809 MFS transport protein AraJ; Provisional; Region: PRK10091 412022011810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011811 putative substrate translocation pore; other site 412022011812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412022011813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022011814 non-specific DNA binding site [nucleotide binding]; other site 412022011815 salt bridge; other site 412022011816 sequence-specific DNA binding site [nucleotide binding]; other site 412022011817 Cupin domain; Region: Cupin_2; pfam07883 412022011818 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 412022011819 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 412022011820 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 412022011821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022011822 motif II; other site 412022011823 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412022011824 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412022011825 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412022011826 active site 412022011827 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 412022011828 dimer interface [polypeptide binding]; other site 412022011829 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412022011830 Ligand Binding Site [chemical binding]; other site 412022011831 Molecular Tunnel; other site 412022011832 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 412022011833 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 412022011834 hinge; other site 412022011835 active site 412022011836 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 412022011837 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 412022011838 putative active site [active] 412022011839 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 412022011840 homotrimer interaction site [polypeptide binding]; other site 412022011841 putative active site [active] 412022011842 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 412022011843 amphipathic channel; other site 412022011844 Asn-Pro-Ala signature motifs; other site 412022011845 glycerol kinase; Provisional; Region: glpK; PRK00047 412022011846 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 412022011847 N- and C-terminal domain interface [polypeptide binding]; other site 412022011848 active site 412022011849 MgATP binding site [chemical binding]; other site 412022011850 catalytic site [active] 412022011851 metal binding site [ion binding]; metal-binding site 412022011852 glycerol binding site [chemical binding]; other site 412022011853 homotetramer interface [polypeptide binding]; other site 412022011854 homodimer interface [polypeptide binding]; other site 412022011855 FBP binding site [chemical binding]; other site 412022011856 protein IIAGlc interface [polypeptide binding]; other site 412022011857 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 412022011858 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412022011859 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 412022011860 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412022011861 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 412022011862 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 412022011863 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 412022011864 dinuclear metal binding motif [ion binding]; other site 412022011865 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412022011866 ATP binding site [chemical binding]; other site 412022011867 Mg++ binding site [ion binding]; other site 412022011868 motif III; other site 412022011869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022011870 nucleotide binding region [chemical binding]; other site 412022011871 ATP-binding site [chemical binding]; other site 412022011872 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412022011873 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412022011874 Cytochrome c; Region: Cytochrom_C; pfam00034 412022011875 Cytochrome c; Region: Cytochrom_C; cl11414 412022011876 Cytochrome c; Region: Cytochrom_C; cl11414 412022011877 Copper resistance protein D; Region: CopD; pfam05425 412022011878 galactonate dehydratase; Provisional; Region: PRK14017 412022011879 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 412022011880 putative active site pocket [active] 412022011881 putative metal binding site [ion binding]; other site 412022011882 Uncharacterized conserved protein [Function unknown]; Region: COG3791 412022011883 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 412022011884 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412022011885 active site 412022011886 metal binding site [ion binding]; metal-binding site 412022011887 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 412022011888 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 412022011889 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 412022011890 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 412022011891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022011892 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 412022011893 linker region; other site 412022011894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022011895 ATP binding site [chemical binding]; other site 412022011896 Mg2+ binding site [ion binding]; other site 412022011897 G-X-G motif; other site 412022011898 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 412022011899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022011900 active site 412022011901 phosphorylation site [posttranslational modification] 412022011902 intermolecular recognition site; other site 412022011903 dimerization interface [polypeptide binding]; other site 412022011904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412022011905 Zn2+ binding site [ion binding]; other site 412022011906 Mg2+ binding site [ion binding]; other site 412022011907 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 412022011908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022011909 PAS domain; Region: PAS_9; pfam13426 412022011910 putative active site [active] 412022011911 heme pocket [chemical binding]; other site 412022011912 HAMP domain; Region: HAMP; pfam00672 412022011913 dimerization interface [polypeptide binding]; other site 412022011914 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412022011915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022011916 dimer interface [polypeptide binding]; other site 412022011917 putative CheW interface [polypeptide binding]; other site 412022011918 Transposase; Region: HTH_Tnp_1; pfam01527 412022011919 HTH-like domain; Region: HTH_21; pfam13276 412022011920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022011921 Integrase core domain; Region: rve; pfam00665 412022011922 Integrase core domain; Region: rve_3; pfam13683 412022011923 Gram-negative bacterial tonB protein; Region: TonB; cl10048 412022011924 hypothetical protein; Provisional; Region: PRK11667 412022011925 O-Antigen ligase; Region: Wzy_C; pfam04932 412022011926 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 412022011927 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 412022011928 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 412022011929 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 412022011930 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 412022011931 CoA binding domain; Region: CoA_binding; smart00881 412022011932 CoA-ligase; Region: Ligase_CoA; pfam00549 412022011933 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 412022011934 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 412022011935 CoA-ligase; Region: Ligase_CoA; pfam00549 412022011936 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 412022011937 recombination regulator RecX; Provisional; Region: recX; PRK14136 412022011938 recombinase A; Provisional; Region: recA; PRK09354 412022011939 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 412022011940 hexamer interface [polypeptide binding]; other site 412022011941 Walker A motif; other site 412022011942 ATP binding site [chemical binding]; other site 412022011943 Walker B motif; other site 412022011944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412022011945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022011946 active site 412022011947 phosphorylation site [posttranslational modification] 412022011948 intermolecular recognition site; other site 412022011949 dimerization interface [polypeptide binding]; other site 412022011950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022011951 DNA binding site [nucleotide binding] 412022011952 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 412022011953 HAMP domain; Region: HAMP; pfam00672 412022011954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022011955 dimer interface [polypeptide binding]; other site 412022011956 phosphorylation site [posttranslational modification] 412022011957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022011958 ATP binding site [chemical binding]; other site 412022011959 Mg2+ binding site [ion binding]; other site 412022011960 G-X-G motif; other site 412022011961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022011962 putative substrate translocation pore; other site 412022011963 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412022011964 HTH-like domain; Region: HTH_21; pfam13276 412022011965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022011966 Integrase core domain; Region: rve; pfam00665 412022011967 Integrase core domain; Region: rve_3; pfam13683 412022011968 Transposase; Region: HTH_Tnp_1; pfam01527 412022011969 Peptidase family M48; Region: Peptidase_M48; pfam01435 412022011970 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 412022011971 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 412022011972 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 412022011973 SnoaL-like domain; Region: SnoaL_3; pfam13474 412022011974 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022011975 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022011976 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022011977 putative active site [active] 412022011978 Zinc-finger domain; Region: zf-CHCC; cl01821 412022011979 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412022011980 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 412022011981 homodimer interface [polypeptide binding]; other site 412022011982 substrate-cofactor binding pocket; other site 412022011983 catalytic residue [active] 412022011984 AzlC protein; Region: AzlC; cl00570 412022011985 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 412022011986 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 412022011987 Phosphoglycerate kinase; Region: PGK; pfam00162 412022011988 substrate binding site [chemical binding]; other site 412022011989 hinge regions; other site 412022011990 ADP binding site [chemical binding]; other site 412022011991 catalytic site [active] 412022011992 pyruvate kinase; Provisional; Region: PRK05826 412022011993 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 412022011994 domain interfaces; other site 412022011995 active site 412022011996 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 412022011997 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 412022011998 intersubunit interface [polypeptide binding]; other site 412022011999 active site 412022012000 zinc binding site [ion binding]; other site 412022012001 Na+ binding site [ion binding]; other site 412022012002 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 412022012003 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 412022012004 ATP binding site [chemical binding]; other site 412022012005 active site 412022012006 substrate binding site [chemical binding]; other site 412022012007 AIR carboxylase; Region: AIRC; pfam00731 412022012008 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 412022012009 ATP-grasp domain; Region: ATP-grasp; pfam02222 412022012010 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 412022012011 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 412022012012 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 412022012013 active site 412022012014 catalytic triad [active] 412022012015 oxyanion hole [active] 412022012016 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 412022012017 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 412022012018 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 412022012019 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 412022012020 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 412022012021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022012022 active site 412022012023 phosphorylation site [posttranslational modification] 412022012024 intermolecular recognition site; other site 412022012025 dimerization interface [polypeptide binding]; other site 412022012026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022012027 DNA binding site [nucleotide binding] 412022012028 sensor protein QseC; Provisional; Region: PRK10337 412022012029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022012030 ATP binding site [chemical binding]; other site 412022012031 Mg2+ binding site [ion binding]; other site 412022012032 G-X-G motif; other site 412022012033 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 412022012034 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412022012035 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022012036 protein binding site [polypeptide binding]; other site 412022012037 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022012038 protein binding site [polypeptide binding]; other site 412022012039 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 412022012040 Domain of unknown function (DUF427); Region: DUF427; pfam04248 412022012041 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 412022012042 hydrophobic ligand binding site; other site 412022012043 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 412022012044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412022012045 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 412022012046 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 412022012047 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022012048 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022012049 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 412022012050 Protein export membrane protein; Region: SecD_SecF; cl14618 412022012051 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 412022012052 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 412022012053 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 412022012054 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022012055 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022012056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022012057 Transposase; Region: HTH_Tnp_1; pfam01527 412022012058 HTH-like domain; Region: HTH_21; pfam13276 412022012059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022012060 Integrase core domain; Region: rve; pfam00665 412022012061 Integrase core domain; Region: rve_3; pfam13683 412022012062 xanthine permease; Region: pbuX; TIGR03173 412022012063 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412022012064 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 412022012065 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022012066 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 412022012067 conserved cys residue [active] 412022012068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022012069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022012070 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 412022012071 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 412022012072 substrate binding site [chemical binding]; other site 412022012073 catalytic Zn binding site [ion binding]; other site 412022012074 NAD binding site [chemical binding]; other site 412022012075 structural Zn binding site [ion binding]; other site 412022012076 dimer interface [polypeptide binding]; other site 412022012077 S-formylglutathione hydrolase; Region: PLN02442 412022012078 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 412022012079 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 412022012080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 412022012081 dimer interface [polypeptide binding]; other site 412022012082 putative PBP binding regions; other site 412022012083 ABC-ATPase subunit interface; other site 412022012084 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 412022012085 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 412022012086 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 412022012087 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 412022012088 metal binding site [ion binding]; metal-binding site 412022012089 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412022012090 metal binding site 2 [ion binding]; metal-binding site 412022012091 putative DNA binding helix; other site 412022012092 metal binding site 1 [ion binding]; metal-binding site 412022012093 dimer interface [polypeptide binding]; other site 412022012094 structural Zn2+ binding site [ion binding]; other site 412022012095 sorbitol dehydrogenase; Provisional; Region: PRK07067 412022012096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022012097 NAD(P) binding site [chemical binding]; other site 412022012098 active site 412022012099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412022012100 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 412022012101 substrate binding site [chemical binding]; other site 412022012102 ATP binding site [chemical binding]; other site 412022012103 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 412022012104 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 412022012105 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 412022012106 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 412022012107 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 412022012108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022012109 dimer interface [polypeptide binding]; other site 412022012110 conserved gate region; other site 412022012111 putative PBP binding loops; other site 412022012112 ABC-ATPase subunit interface; other site 412022012113 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 412022012114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022012115 dimer interface [polypeptide binding]; other site 412022012116 conserved gate region; other site 412022012117 putative PBP binding loops; other site 412022012118 ABC-ATPase subunit interface; other site 412022012119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022012120 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 412022012121 active site 412022012122 motif I; other site 412022012123 motif II; other site 412022012124 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 412022012125 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 412022012126 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 412022012127 Walker A/P-loop; other site 412022012128 ATP binding site [chemical binding]; other site 412022012129 Q-loop/lid; other site 412022012130 ABC transporter signature motif; other site 412022012131 Walker B; other site 412022012132 D-loop; other site 412022012133 H-loop/switch region; other site 412022012134 TOBE domain; Region: TOBE; pfam03459 412022012135 TOBE domain; Region: TOBE_2; pfam08402 412022012136 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 412022012137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022012138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022012139 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 412022012140 putative effector binding pocket; other site 412022012141 putative dimerization interface [polypeptide binding]; other site 412022012142 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412022012143 Beta-lactamase; Region: Beta-lactamase; pfam00144 412022012144 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412022012145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012146 putative substrate translocation pore; other site 412022012147 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 412022012148 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 412022012149 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 412022012150 N- and C-terminal domain interface [polypeptide binding]; other site 412022012151 D-xylulose kinase; Region: XylB; TIGR01312 412022012152 active site 412022012153 MgATP binding site [chemical binding]; other site 412022012154 catalytic site [active] 412022012155 metal binding site [ion binding]; metal-binding site 412022012156 xylulose binding site [chemical binding]; other site 412022012157 homodimer interface [polypeptide binding]; other site 412022012158 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 412022012159 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 412022012160 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 412022012161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022012162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022012163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022012164 dimerization interface [polypeptide binding]; other site 412022012165 benzoylformate decarboxylase; Reviewed; Region: PRK07092 412022012166 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412022012167 PYR/PP interface [polypeptide binding]; other site 412022012168 dimer interface [polypeptide binding]; other site 412022012169 TPP binding site [chemical binding]; other site 412022012170 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412022012171 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 412022012172 TPP-binding site [chemical binding]; other site 412022012173 dimer interface [polypeptide binding]; other site 412022012174 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 412022012175 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 412022012176 NAD(P) binding site [chemical binding]; other site 412022012177 catalytic residues [active] 412022012178 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 412022012179 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 412022012180 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 412022012181 benzoate transport; Region: 2A0115; TIGR00895 412022012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012183 putative substrate translocation pore; other site 412022012184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012185 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 412022012186 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 412022012187 kynureninase; Region: kynureninase; TIGR01814 412022012188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022012189 catalytic residue [active] 412022012190 Putative cyclase; Region: Cyclase; cl00814 412022012191 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412022012192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022012193 putative DNA binding site [nucleotide binding]; other site 412022012194 putative Zn2+ binding site [ion binding]; other site 412022012195 AsnC family; Region: AsnC_trans_reg; pfam01037 412022012196 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 412022012197 methionine sulfoxide reductase A; Provisional; Region: PRK14054 412022012198 Protein of unknown function DUF72; Region: DUF72; pfam01904 412022012199 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 412022012200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022012201 S-adenosylmethionine binding site [chemical binding]; other site 412022012202 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 412022012203 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 412022012204 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 412022012205 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 412022012206 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 412022012207 putative ATP binding site [chemical binding]; other site 412022012208 putative substrate interface [chemical binding]; other site 412022012209 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 412022012210 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412022012211 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412022012212 catalytic residues [active] 412022012213 Pirin-related protein [General function prediction only]; Region: COG1741 412022012214 Pirin; Region: Pirin; pfam02678 412022012215 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 412022012216 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 412022012217 EamA-like transporter family; Region: EamA; pfam00892 412022012218 AMIN domain; Region: AMIN; pfam11741 412022012219 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412022012220 active site 412022012221 metal binding site [ion binding]; metal-binding site 412022012222 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 412022012223 epoxyqueuosine reductase; Region: TIGR00276 412022012224 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 412022012225 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 412022012226 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 412022012227 DNA binding site [nucleotide binding] 412022012228 active site 412022012229 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 412022012230 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 412022012231 active site 412022012232 Int/Topo IB signature motif; other site 412022012233 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 412022012234 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412022012235 acyl-activating enzyme (AAE) consensus motif; other site 412022012236 AMP binding site [chemical binding]; other site 412022012237 active site 412022012238 CoA binding site [chemical binding]; other site 412022012239 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 412022012240 putative deacylase active site [active] 412022012241 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 412022012242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 412022012243 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 412022012244 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 412022012245 FAD binding domain; Region: FAD_binding_4; pfam01565 412022012246 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 412022012247 ornithine carbamoyltransferase; Provisional; Region: PRK00779 412022012248 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412022012249 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412022012250 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 412022012251 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 412022012252 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 412022012253 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 412022012254 Uncharacterized conserved protein [Function unknown]; Region: COG2912 412022012255 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 412022012256 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 412022012257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022012258 NAD(P) binding site [chemical binding]; other site 412022012259 active site 412022012260 Transposase domain (DUF772); Region: DUF772; pfam05598 412022012261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022012262 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022012263 Transposase; Region: HTH_Tnp_1; pfam01527 412022012264 HTH-like domain; Region: HTH_21; pfam13276 412022012265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022012266 Integrase core domain; Region: rve; pfam00665 412022012267 Integrase core domain; Region: rve_3; pfam13683 412022012268 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022012269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412022012270 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 412022012271 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 412022012272 Rubredoxin; Region: Rubredoxin; pfam00301 412022012273 iron binding site [ion binding]; other site 412022012274 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 412022012275 ABC transporter ATPase component; Reviewed; Region: PRK11147 412022012276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022012277 Walker A/P-loop; other site 412022012278 ATP binding site [chemical binding]; other site 412022012279 Q-loop/lid; other site 412022012280 ABC transporter signature motif; other site 412022012281 Walker B; other site 412022012282 D-loop; other site 412022012283 H-loop/switch region; other site 412022012284 ABC transporter; Region: ABC_tran_2; pfam12848 412022012285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022012286 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 412022012287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022012288 ATP binding site [chemical binding]; other site 412022012289 Mg2+ binding site [ion binding]; other site 412022012290 G-X-G motif; other site 412022012291 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412022012292 anchoring element; other site 412022012293 dimer interface [polypeptide binding]; other site 412022012294 ATP binding site [chemical binding]; other site 412022012295 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 412022012296 active site 412022012297 metal binding site [ion binding]; metal-binding site 412022012298 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412022012299 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 412022012300 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412022012301 CAP-like domain; other site 412022012302 active site 412022012303 primary dimer interface [polypeptide binding]; other site 412022012304 Predicted integral membrane protein [Function unknown]; Region: COG5615 412022012305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022012306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022012307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022012308 dimerization interface [polypeptide binding]; other site 412022012309 Predicted membrane protein [Function unknown]; Region: COG4125 412022012310 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 412022012311 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 412022012312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022012313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022012314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412022012315 dimerization interface [polypeptide binding]; other site 412022012316 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022012317 allantoate amidohydrolase; Reviewed; Region: PRK12893 412022012318 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 412022012319 active site 412022012320 metal binding site [ion binding]; metal-binding site 412022012321 dimer interface [polypeptide binding]; other site 412022012322 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 412022012323 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 412022012324 active site 412022012325 Zn binding site [ion binding]; other site 412022012326 Chromate transporter; Region: Chromate_transp; pfam02417 412022012327 Chromate transporter; Region: Chromate_transp; pfam02417 412022012328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412022012329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412022012330 metal binding site [ion binding]; metal-binding site 412022012331 active site 412022012332 I-site; other site 412022012333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412022012334 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 412022012335 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 412022012336 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 412022012337 homotrimer interaction site [polypeptide binding]; other site 412022012338 putative active site [active] 412022012339 HTH-like domain; Region: HTH_21; pfam13276 412022012340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022012341 Integrase core domain; Region: rve; pfam00665 412022012342 Integrase core domain; Region: rve_3; pfam13683 412022012343 Transposase; Region: HTH_Tnp_1; pfam01527 412022012344 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 412022012345 Mg++ binding site [ion binding]; other site 412022012346 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 412022012347 putative catalytic motif [active] 412022012348 UDP-glucose 4-epimerase; Region: PLN02240 412022012349 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 412022012350 NAD binding site [chemical binding]; other site 412022012351 homodimer interface [polypeptide binding]; other site 412022012352 active site 412022012353 substrate binding site [chemical binding]; other site 412022012354 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 412022012355 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022012356 putative ADP-binding pocket [chemical binding]; other site 412022012357 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 412022012358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412022012359 active site 412022012360 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 412022012361 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 412022012362 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 412022012363 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 412022012364 active site 412022012365 substrate binding site [chemical binding]; other site 412022012366 metal binding site [ion binding]; metal-binding site 412022012367 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022012368 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022012369 putative active site [active] 412022012370 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 412022012371 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 412022012372 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 412022012373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412022012374 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412022012375 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 412022012376 UreF; Region: UreF; pfam01730 412022012377 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 412022012378 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 412022012379 dimer interface [polypeptide binding]; other site 412022012380 catalytic residues [active] 412022012381 urease subunit alpha; Reviewed; Region: ureC; PRK13207 412022012382 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 412022012383 subunit interactions [polypeptide binding]; other site 412022012384 active site 412022012385 flap region; other site 412022012386 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 412022012387 gamma-beta subunit interface [polypeptide binding]; other site 412022012388 alpha-beta subunit interface [polypeptide binding]; other site 412022012389 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 412022012390 alpha-gamma subunit interface [polypeptide binding]; other site 412022012391 beta-gamma subunit interface [polypeptide binding]; other site 412022012392 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 412022012393 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 412022012394 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412022012395 Walker A/P-loop; other site 412022012396 ATP binding site [chemical binding]; other site 412022012397 Q-loop/lid; other site 412022012398 ABC transporter signature motif; other site 412022012399 Walker B; other site 412022012400 D-loop; other site 412022012401 H-loop/switch region; other site 412022012402 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 412022012403 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412022012404 Walker A/P-loop; other site 412022012405 ATP binding site [chemical binding]; other site 412022012406 Q-loop/lid; other site 412022012407 ABC transporter signature motif; other site 412022012408 Walker B; other site 412022012409 D-loop; other site 412022012410 H-loop/switch region; other site 412022012411 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412022012412 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412022012413 TM-ABC transporter signature motif; other site 412022012414 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 412022012415 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412022012416 TM-ABC transporter signature motif; other site 412022012417 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 412022012418 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 412022012419 putative ligand binding site [chemical binding]; other site 412022012420 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 412022012421 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022012422 inhibitor-cofactor binding pocket; inhibition site 412022012423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022012424 catalytic residue [active] 412022012425 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 412022012426 active site residue [active] 412022012427 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 412022012428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412022012429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022012430 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 412022012431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022012432 FeS/SAM binding site; other site 412022012433 HemN C-terminal domain; Region: HemN_C; pfam06969 412022012434 Flagellin N-methylase; Region: FliB; pfam03692 412022012435 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 412022012436 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 412022012437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022012438 S-adenosylmethionine binding site [chemical binding]; other site 412022012439 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 412022012440 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022012441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022012442 S-adenosylmethionine binding site [chemical binding]; other site 412022012443 Transposase domain (DUF772); Region: DUF772; pfam05598 412022012444 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022012445 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022012446 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 412022012447 active site 412022012448 catalytic triad [active] 412022012449 calcium binding site [ion binding]; other site 412022012450 chromosome condensation membrane protein; Provisional; Region: PRK14196 412022012451 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 412022012452 YGGT family; Region: YGGT; pfam02325 412022012453 YGGT family; Region: YGGT; pfam02325 412022012454 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 412022012455 Rossmann-like domain; Region: Rossmann-like; pfam10727 412022012456 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 412022012457 serine racemase; Region: PLN02970 412022012458 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412022012459 tetramer interface [polypeptide binding]; other site 412022012460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022012461 catalytic residue [active] 412022012462 LysE type translocator; Region: LysE; cl00565 412022012463 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 412022012464 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 412022012465 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412022012466 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412022012467 catalytic residue [active] 412022012468 aminotransferase; Validated; Region: PRK07337 412022012469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022012470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022012471 homodimer interface [polypeptide binding]; other site 412022012472 catalytic residue [active] 412022012473 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 412022012474 putative RNA binding site [nucleotide binding]; other site 412022012475 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 412022012476 homopentamer interface [polypeptide binding]; other site 412022012477 active site 412022012478 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 412022012479 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 412022012480 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 412022012481 dimerization interface [polypeptide binding]; other site 412022012482 active site 412022012483 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 412022012484 Lumazine binding domain; Region: Lum_binding; pfam00677 412022012485 Lumazine binding domain; Region: Lum_binding; pfam00677 412022012486 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 412022012487 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 412022012488 catalytic motif [active] 412022012489 Zn binding site [ion binding]; other site 412022012490 RibD C-terminal domain; Region: RibD_C; cl17279 412022012491 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 412022012492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022012493 inhibitor-cofactor binding pocket; inhibition site 412022012494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022012495 catalytic residue [active] 412022012496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012497 putative substrate translocation pore; other site 412022012498 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 412022012499 D-cysteine desulfhydrase; Validated; Region: PRK03910 412022012500 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 412022012501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022012502 catalytic residue [active] 412022012503 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412022012504 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022012505 Walker A/P-loop; other site 412022012506 ATP binding site [chemical binding]; other site 412022012507 Q-loop/lid; other site 412022012508 ABC transporter signature motif; other site 412022012509 Walker B; other site 412022012510 D-loop; other site 412022012511 H-loop/switch region; other site 412022012512 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022012513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022012514 dimer interface [polypeptide binding]; other site 412022012515 conserved gate region; other site 412022012516 putative PBP binding loops; other site 412022012517 ABC-ATPase subunit interface; other site 412022012518 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412022012519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022012520 substrate binding pocket [chemical binding]; other site 412022012521 membrane-bound complex binding site; other site 412022012522 hinge residues; other site 412022012523 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 412022012524 Glucokinase; Region: Glucokinase; pfam02685 412022012525 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412022012526 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412022012527 putative active site [active] 412022012528 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 412022012529 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 412022012530 putative active site [active] 412022012531 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 412022012532 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 412022012533 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 412022012534 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 412022012535 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 412022012536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022012537 dimer interface [polypeptide binding]; other site 412022012538 conserved gate region; other site 412022012539 putative PBP binding loops; other site 412022012540 ABC-ATPase subunit interface; other site 412022012541 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 412022012542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022012543 dimer interface [polypeptide binding]; other site 412022012544 conserved gate region; other site 412022012545 putative PBP binding loops; other site 412022012546 ABC-ATPase subunit interface; other site 412022012547 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 412022012548 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 412022012549 Walker A/P-loop; other site 412022012550 ATP binding site [chemical binding]; other site 412022012551 Q-loop/lid; other site 412022012552 ABC transporter signature motif; other site 412022012553 Walker B; other site 412022012554 D-loop; other site 412022012555 H-loop/switch region; other site 412022012556 Predicted membrane protein [Function unknown]; Region: COG2860 412022012557 UPF0126 domain; Region: UPF0126; pfam03458 412022012558 UPF0126 domain; Region: UPF0126; pfam03458 412022012559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 412022012560 Smr domain; Region: Smr; pfam01713 412022012561 thioredoxin reductase; Provisional; Region: PRK10262 412022012562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022012563 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 412022012564 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412022012565 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 412022012566 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 412022012567 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 412022012568 recombination factor protein RarA; Reviewed; Region: PRK13342 412022012569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022012570 Walker A motif; other site 412022012571 ATP binding site [chemical binding]; other site 412022012572 Walker B motif; other site 412022012573 arginine finger; other site 412022012574 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 412022012575 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 412022012576 seryl-tRNA synthetase; Provisional; Region: PRK05431 412022012577 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 412022012578 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 412022012579 dimer interface [polypeptide binding]; other site 412022012580 active site 412022012581 motif 1; other site 412022012582 motif 2; other site 412022012583 motif 3; other site 412022012584 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412022012585 septum formation inhibitor; Reviewed; Region: PRK01973 412022012586 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 412022012587 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 412022012588 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 412022012589 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 412022012590 Switch I; other site 412022012591 Switch II; other site 412022012592 cell division topological specificity factor MinE; Provisional; Region: PRK13989 412022012593 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 412022012594 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 412022012595 putative ion selectivity filter; other site 412022012596 putative pore gating glutamate residue; other site 412022012597 putative H+/Cl- coupling transport residue; other site 412022012598 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 412022012599 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 412022012600 putative active site [active] 412022012601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012602 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022012603 putative substrate translocation pore; other site 412022012604 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 412022012605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412022012606 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 412022012607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022012608 FeS/SAM binding site; other site 412022012609 HemN C-terminal domain; Region: HemN_C; pfam06969 412022012610 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 412022012611 active site 412022012612 dimerization interface [polypeptide binding]; other site 412022012613 ribonuclease PH; Reviewed; Region: rph; PRK00173 412022012614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 412022012615 hexamer interface [polypeptide binding]; other site 412022012616 active site 412022012617 hypothetical protein; Provisional; Region: PRK11820 412022012618 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 412022012619 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 412022012620 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 412022012621 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 412022012622 catalytic site [active] 412022012623 G-X2-G-X-G-K; other site 412022012624 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 412022012625 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412022012626 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412022012627 Zn2+ binding site [ion binding]; other site 412022012628 Mg2+ binding site [ion binding]; other site 412022012629 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412022012630 synthetase active site [active] 412022012631 NTP binding site [chemical binding]; other site 412022012632 metal binding site [ion binding]; metal-binding site 412022012633 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412022012634 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 412022012635 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 412022012636 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 412022012637 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412022012638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022012639 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022012640 HTH-like domain; Region: HTH_21; pfam13276 412022012641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022012642 Integrase core domain; Region: rve; pfam00665 412022012643 Integrase core domain; Region: rve_3; pfam13683 412022012644 Transposase; Region: HTH_Tnp_1; pfam01527 412022012645 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 412022012646 Tetratricopeptide repeat; Region: TPR_6; pfam13174 412022012647 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 412022012648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022012649 ligand binding site [chemical binding]; other site 412022012650 translocation protein TolB; Provisional; Region: tolB; PRK02889 412022012651 TolB amino-terminal domain; Region: TolB_N; pfam04052 412022012652 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412022012653 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412022012654 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412022012655 TolA protein; Region: tolA_full; TIGR02794 412022012656 TonB C terminal; Region: TonB_2; pfam13103 412022012657 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 412022012658 TolR protein; Region: tolR; TIGR02801 412022012659 TolQ protein; Region: tolQ; TIGR02796 412022012660 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 412022012661 active site 412022012662 malonic semialdehyde reductase; Provisional; Region: PRK10538 412022012663 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 412022012664 putative NAD(P) binding site [chemical binding]; other site 412022012665 homodimer interface [polypeptide binding]; other site 412022012666 homotetramer interface [polypeptide binding]; other site 412022012667 active site 412022012668 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 412022012669 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 412022012670 dimer interface [polypeptide binding]; other site 412022012671 active site 412022012672 glycine-pyridoxal phosphate binding site [chemical binding]; other site 412022012673 folate binding site [chemical binding]; other site 412022012674 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 412022012675 ATP cone domain; Region: ATP-cone; pfam03477 412022012676 Type II transport protein GspH; Region: GspH; pfam12019 412022012677 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 412022012678 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 412022012679 Predicted membrane protein [Function unknown]; Region: COG5393 412022012680 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 412022012681 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 412022012682 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 412022012683 dimer interface [polypeptide binding]; other site 412022012684 decamer (pentamer of dimers) interface [polypeptide binding]; other site 412022012685 catalytic triad [active] 412022012686 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 412022012687 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022012688 FAD binding site [chemical binding]; other site 412022012689 substrate binding pocket [chemical binding]; other site 412022012690 catalytic base [active] 412022012691 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022012692 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022012693 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022012694 Uncharacterized conserved protein [Function unknown]; Region: COG3791 412022012695 EAL domain; Region: EAL; pfam00563 412022012696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412022012697 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 412022012698 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412022012699 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 412022012700 benzoate transport; Region: 2A0115; TIGR00895 412022012701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012702 putative substrate translocation pore; other site 412022012703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012704 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 412022012705 fumarylacetoacetase; Region: PLN02856 412022012706 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 412022012707 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412022012708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022012710 putative substrate translocation pore; other site 412022012711 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412022012712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012713 putative substrate translocation pore; other site 412022012714 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 412022012715 putative FMN binding site [chemical binding]; other site 412022012716 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 412022012717 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 412022012718 putative ligand binding site [chemical binding]; other site 412022012719 putative NAD binding site [chemical binding]; other site 412022012720 catalytic site [active] 412022012721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022012722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022012723 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022012724 putative effector binding pocket; other site 412022012725 dimerization interface [polypeptide binding]; other site 412022012726 Transposase; Region: HTH_Tnp_1; pfam01527 412022012727 HTH-like domain; Region: HTH_21; pfam13276 412022012728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022012729 Integrase core domain; Region: rve; pfam00665 412022012730 Integrase core domain; Region: rve_3; pfam13683 412022012731 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 412022012732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022012733 catalytic residue [active] 412022012734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412022012735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022012736 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 412022012737 EamA-like transporter family; Region: EamA; pfam00892 412022012738 EamA-like transporter family; Region: EamA; pfam00892 412022012739 major facilitator superfamily transporter; Provisional; Region: PRK05122 412022012740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012741 putative substrate translocation pore; other site 412022012742 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 412022012743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022012744 catalytic loop [active] 412022012745 iron binding site [ion binding]; other site 412022012746 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 412022012747 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 412022012748 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 412022012749 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 412022012750 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 412022012751 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 412022012752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412022012753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 412022012754 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 412022012755 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022012756 N-terminal plug; other site 412022012757 ligand-binding site [chemical binding]; other site 412022012758 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412022012759 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412022012760 Walker A/P-loop; other site 412022012761 ATP binding site [chemical binding]; other site 412022012762 Q-loop/lid; other site 412022012763 ABC transporter signature motif; other site 412022012764 Walker B; other site 412022012765 D-loop; other site 412022012766 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412022012767 intersubunit interface [polypeptide binding]; other site 412022012768 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412022012769 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412022012770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412022012771 dimer interface [polypeptide binding]; other site 412022012772 putative PBP binding regions; other site 412022012773 ABC-ATPase subunit interface; other site 412022012774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022012775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022012776 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022012777 dimerization interface [polypeptide binding]; other site 412022012778 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 412022012779 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 412022012780 putative catalytic residue [active] 412022012781 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 412022012782 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 412022012783 BON domain; Region: BON; pfam04972 412022012784 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 412022012785 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 412022012786 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 412022012787 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 412022012788 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412022012789 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412022012790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022012791 putative substrate translocation pore; other site 412022012792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412022012793 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 412022012794 putative active site [active] 412022012795 catalytic site [active] 412022012796 putative metal binding site [ion binding]; other site 412022012797 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412022012798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022012799 Coenzyme A binding pocket [chemical binding]; other site 412022012800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412022012801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022012802 salt bridge; other site 412022012803 non-specific DNA binding site [nucleotide binding]; other site 412022012804 sequence-specific DNA binding site [nucleotide binding]; other site 412022012805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412022012806 Predicted transcriptional regulators [Transcription]; Region: COG1733 412022012807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412022012808 dimerization interface [polypeptide binding]; other site 412022012809 putative DNA binding site [nucleotide binding]; other site 412022012810 putative Zn2+ binding site [ion binding]; other site 412022012811 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 412022012812 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 412022012813 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 412022012814 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 412022012815 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412022012816 putative NAD(P) binding site [chemical binding]; other site 412022012817 Predicted transcriptional regulators [Transcription]; Region: COG1733 412022012818 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 412022012819 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 412022012820 oligomerisation interface [polypeptide binding]; other site 412022012821 mobile loop; other site 412022012822 roof hairpin; other site 412022012823 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 412022012824 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 412022012825 ring oligomerisation interface [polypeptide binding]; other site 412022012826 ATP/Mg binding site [chemical binding]; other site 412022012827 stacking interactions; other site 412022012828 hinge regions; other site 412022012829 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 412022012830 dimer interface [polypeptide binding]; other site 412022012831 substrate binding site [chemical binding]; other site 412022012832 ATP binding site [chemical binding]; other site 412022012833 Rubredoxin [Energy production and conversion]; Region: COG1773 412022012834 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 412022012835 iron binding site [ion binding]; other site 412022012836 hypothetical protein; Validated; Region: PRK00228 412022012837 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 412022012838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412022012839 active site 412022012840 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 412022012841 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412022012842 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412022012843 dihydroorotase; Provisional; Region: PRK07627 412022012844 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412022012845 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 412022012846 active site 412022012847 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412022012848 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412022012849 putative acyl-acceptor binding pocket; other site 412022012850 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 412022012851 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 412022012852 active site 412022012853 metal binding site [ion binding]; metal-binding site 412022012854 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 412022012855 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 412022012856 NAD binding site [chemical binding]; other site 412022012857 substrate binding site [chemical binding]; other site 412022012858 homodimer interface [polypeptide binding]; other site 412022012859 active site 412022012860 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 412022012861 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 412022012862 substrate binding site; other site 412022012863 tetramer interface; other site 412022012864 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 412022012865 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 412022012866 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 412022012867 NADP binding site [chemical binding]; other site 412022012868 active site 412022012869 putative substrate binding site [chemical binding]; other site 412022012870 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 412022012871 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 412022012872 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 412022012873 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 412022012874 Walker A/P-loop; other site 412022012875 ATP binding site [chemical binding]; other site 412022012876 Q-loop/lid; other site 412022012877 ABC transporter signature motif; other site 412022012878 Walker B; other site 412022012879 D-loop; other site 412022012880 H-loop/switch region; other site 412022012881 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 412022012882 putative carbohydrate binding site [chemical binding]; other site 412022012883 Acyltransferase family; Region: Acyl_transf_3; pfam01757 412022012884 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022012885 extended (e) SDRs; Region: SDR_e; cd08946 412022012886 NAD(P) binding site [chemical binding]; other site 412022012887 active site 412022012888 substrate binding site [chemical binding]; other site 412022012889 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 412022012890 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 412022012891 Probable Catalytic site; other site 412022012892 metal-binding site 412022012893 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412022012894 Methyltransferase domain; Region: Methyltransf_12; pfam08242 412022012895 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412022012896 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 412022012897 active site 412022012898 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 412022012899 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 412022012900 Probable Catalytic site; other site 412022012901 metal-binding site 412022012902 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412022012903 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 412022012904 active site 412022012905 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 412022012906 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412022012907 active site 412022012908 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412022012909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412022012910 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 412022012911 putative NAD(P) binding site [chemical binding]; other site 412022012912 active site 412022012913 putative substrate binding site [chemical binding]; other site 412022012914 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 412022012915 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 412022012916 Mg++ binding site [ion binding]; other site 412022012917 putative catalytic motif [active] 412022012918 putative substrate binding site [chemical binding]; other site 412022012919 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 412022012920 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 412022012921 NAD(P) binding site [chemical binding]; other site 412022012922 homodimer interface [polypeptide binding]; other site 412022012923 substrate binding site [chemical binding]; other site 412022012924 active site 412022012925 HTH-like domain; Region: HTH_21; pfam13276 412022012926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022012927 Integrase core domain; Region: rve; pfam00665 412022012928 Integrase core domain; Region: rve_3; pfam13683 412022012929 Transposase; Region: HTH_Tnp_1; pfam01527 412022012930 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 412022012931 multidrug efflux protein; Reviewed; Region: PRK01766 412022012932 cation binding site [ion binding]; other site 412022012933 S4 domain; Region: S4_2; pfam13275 412022012934 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 412022012935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 412022012936 CreA protein; Region: CreA; pfam05981 412022012937 Ferredoxin [Energy production and conversion]; Region: COG1146 412022012938 4Fe-4S binding domain; Region: Fer4; cl02805 412022012939 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 412022012940 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 412022012941 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 412022012942 active site 412022012943 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 412022012944 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412022012945 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 412022012946 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 412022012947 dimerization interface [polypeptide binding]; other site 412022012948 ligand binding site [chemical binding]; other site 412022012949 NADP binding site [chemical binding]; other site 412022012950 catalytic site [active] 412022012951 RmuC family; Region: RmuC; pfam02646 412022012952 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412022012953 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412022012954 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412022012955 dimer interface [polypeptide binding]; other site 412022012956 putative functional site; other site 412022012957 putative MPT binding site; other site 412022012958 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 412022012959 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 412022012960 GTP binding site; other site 412022012961 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 412022012962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022012963 FeS/SAM binding site; other site 412022012964 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 412022012965 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 412022012966 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 412022012967 homodimer interface [polypeptide binding]; other site 412022012968 oligonucleotide binding site [chemical binding]; other site 412022012969 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 412022012970 S4 domain; Region: S4; pfam01479 412022012971 RNA binding surface [nucleotide binding]; other site 412022012972 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412022012973 active site 412022012974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 412022012975 motif I; other site 412022012976 active site 412022012977 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 412022012978 iron-sulfur cluster [ion binding]; other site 412022012979 [2Fe-2S] cluster binding site [ion binding]; other site 412022012980 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 412022012981 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 412022012982 tandem repeat interface [polypeptide binding]; other site 412022012983 oligomer interface [polypeptide binding]; other site 412022012984 active site residues [active] 412022012985 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 412022012986 putative SAM binding site [chemical binding]; other site 412022012987 homodimer interface [polypeptide binding]; other site 412022012988 Maf-like protein; Region: Maf; pfam02545 412022012989 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 412022012990 active site 412022012991 dimer interface [polypeptide binding]; other site 412022012992 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 412022012993 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 412022012994 putative phosphate acyltransferase; Provisional; Region: PRK05331 412022012995 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 412022012996 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412022012997 dimer interface [polypeptide binding]; other site 412022012998 active site 412022012999 CoA binding pocket [chemical binding]; other site 412022013000 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 412022013001 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412022013002 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 412022013003 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 412022013004 NAD(P) binding site [chemical binding]; other site 412022013005 homotetramer interface [polypeptide binding]; other site 412022013006 homodimer interface [polypeptide binding]; other site 412022013007 active site 412022013008 acyl carrier protein; Provisional; Region: acpP; PRK00982 412022013009 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 412022013010 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412022013011 dimer interface [polypeptide binding]; other site 412022013012 active site 412022013013 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 412022013014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022013015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022013016 DNA binding residues [nucleotide binding] 412022013017 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 412022013018 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 412022013019 anti-sigma E factor; Provisional; Region: rseB; PRK09455 412022013020 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 412022013021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412022013022 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022013023 protein binding site [polypeptide binding]; other site 412022013024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412022013025 protein binding site [polypeptide binding]; other site 412022013026 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 412022013027 GTP-binding protein LepA; Provisional; Region: PRK05433 412022013028 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 412022013029 G1 box; other site 412022013030 putative GEF interaction site [polypeptide binding]; other site 412022013031 GTP/Mg2+ binding site [chemical binding]; other site 412022013032 Switch I region; other site 412022013033 G2 box; other site 412022013034 G3 box; other site 412022013035 Switch II region; other site 412022013036 G4 box; other site 412022013037 G5 box; other site 412022013038 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 412022013039 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 412022013040 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 412022013041 signal peptidase I; Provisional; Region: PRK10861 412022013042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412022013043 Catalytic site [active] 412022013044 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412022013045 ribonuclease III; Provisional; Region: PRK14718 412022013046 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 412022013047 dimerization interface [polypeptide binding]; other site 412022013048 active site 412022013049 metal binding site [ion binding]; metal-binding site 412022013050 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 412022013051 GTPase Era; Reviewed; Region: era; PRK00089 412022013052 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 412022013053 G1 box; other site 412022013054 GTP/Mg2+ binding site [chemical binding]; other site 412022013055 Switch I region; other site 412022013056 G2 box; other site 412022013057 Switch II region; other site 412022013058 G3 box; other site 412022013059 G4 box; other site 412022013060 G5 box; other site 412022013061 KH domain; Region: KH_2; pfam07650 412022013062 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 412022013063 Recombination protein O N terminal; Region: RecO_N; pfam11967 412022013064 Recombination protein O C terminal; Region: RecO_C; pfam02565 412022013065 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 412022013066 active site 412022013067 hydrophilic channel; other site 412022013068 dimerization interface [polypeptide binding]; other site 412022013069 catalytic residues [active] 412022013070 active site lid [active] 412022013071 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 412022013072 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 412022013073 beta-hexosaminidase; Provisional; Region: PRK05337 412022013074 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412022013075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022013076 active site 412022013077 phosphorylation site [posttranslational modification] 412022013078 intermolecular recognition site; other site 412022013079 dimerization interface [polypeptide binding]; other site 412022013080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022013081 Walker A motif; other site 412022013082 ATP binding site [chemical binding]; other site 412022013083 Walker B motif; other site 412022013084 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022013085 elongation factor P; Validated; Region: PRK00529 412022013086 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 412022013087 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 412022013088 RNA binding site [nucleotide binding]; other site 412022013089 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 412022013090 RNA binding site [nucleotide binding]; other site 412022013091 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 412022013092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 412022013093 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 412022013094 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 412022013095 GIY-YIG motif/motif A; other site 412022013096 active site 412022013097 catalytic site [active] 412022013098 putative DNA binding site [nucleotide binding]; other site 412022013099 metal binding site [ion binding]; metal-binding site 412022013100 UvrB/uvrC motif; Region: UVR; pfam02151 412022013101 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 412022013102 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 412022013103 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 412022013104 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 412022013105 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 412022013106 LysR family transcriptional regulator; Provisional; Region: PRK14997 412022013107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022013108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 412022013109 putative effector binding pocket; other site 412022013110 putative dimerization interface [polypeptide binding]; other site 412022013111 Pirin-related protein [General function prediction only]; Region: COG1741 412022013112 Pirin; Region: Pirin; pfam02678 412022013113 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 412022013114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412022013115 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 412022013116 Protein of unknown function (DUF461); Region: DUF461; pfam04314 412022013117 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 412022013118 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412022013119 Cu(I) binding site [ion binding]; other site 412022013120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022013121 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 412022013122 active site 412022013123 motif I; other site 412022013124 motif II; other site 412022013125 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 412022013126 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 412022013127 active site 412022013128 homotetramer interface [polypeptide binding]; other site 412022013129 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412022013130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412022013131 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 412022013132 Walker A/P-loop; other site 412022013133 ATP binding site [chemical binding]; other site 412022013134 Q-loop/lid; other site 412022013135 ABC transporter signature motif; other site 412022013136 Walker B; other site 412022013137 D-loop; other site 412022013138 H-loop/switch region; other site 412022013139 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 412022013140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022013141 putative ADP-binding pocket [chemical binding]; other site 412022013142 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 412022013143 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412022013144 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 412022013145 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 412022013146 dimerization interface [polypeptide binding]; other site 412022013147 ligand binding site [chemical binding]; other site 412022013148 HTH-like domain; Region: HTH_21; pfam13276 412022013149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022013150 Integrase core domain; Region: rve; pfam00665 412022013151 Integrase core domain; Region: rve_3; pfam13683 412022013152 Transposase; Region: HTH_Tnp_1; pfam01527 412022013153 putative membrane protein; Region: HpnL; TIGR03476 412022013154 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 412022013155 putative active site [active] 412022013156 YdjC motif; other site 412022013157 Mg binding site [ion binding]; other site 412022013158 putative homodimer interface [polypeptide binding]; other site 412022013159 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 412022013160 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 412022013161 B12 binding site [chemical binding]; other site 412022013162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022013163 FeS/SAM binding site; other site 412022013164 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 412022013165 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 412022013166 ligand binding site; other site 412022013167 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 412022013168 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 412022013169 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 412022013170 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022013171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412022013172 pyridoxamine kinase; Validated; Region: PRK05756 412022013173 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 412022013174 dimer interface [polypeptide binding]; other site 412022013175 pyridoxal binding site [chemical binding]; other site 412022013176 ATP binding site [chemical binding]; other site 412022013177 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 412022013178 Phosphoesterase family; Region: Phosphoesterase; pfam04185 412022013179 Domain of unknown function (DUF756); Region: DUF756; pfam05506 412022013180 Domain of unknown function (DUF756); Region: DUF756; pfam05506 412022013181 Transposase; Region: HTH_Tnp_1; pfam01527 412022013182 HTH-like domain; Region: HTH_21; pfam13276 412022013183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022013184 Integrase core domain; Region: rve; pfam00665 412022013185 Integrase core domain; Region: rve_3; pfam13683 412022013186 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022013187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022013188 dimer interface [polypeptide binding]; other site 412022013189 conserved gate region; other site 412022013190 putative PBP binding loops; other site 412022013191 ABC-ATPase subunit interface; other site 412022013192 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 412022013193 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022013194 Walker A/P-loop; other site 412022013195 ATP binding site [chemical binding]; other site 412022013196 Q-loop/lid; other site 412022013197 ABC transporter signature motif; other site 412022013198 Walker B; other site 412022013199 D-loop; other site 412022013200 H-loop/switch region; other site 412022013201 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 412022013202 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 412022013203 conserved cys residue [active] 412022013204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022013205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022013206 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 412022013207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412022013208 inhibitor-cofactor binding pocket; inhibition site 412022013209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022013210 catalytic residue [active] 412022013211 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 412022013212 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 412022013213 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 412022013214 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 412022013215 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 412022013216 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 412022013217 NAD(P) binding site [chemical binding]; other site 412022013218 catalytic residues [active] 412022013219 succinylarginine dihydrolase; Provisional; Region: PRK13281 412022013220 succinylglutamate desuccinylase; Provisional; Region: PRK05324 412022013221 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 412022013222 active site 412022013223 Zn binding site [ion binding]; other site 412022013224 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 412022013225 dimer interface [polypeptide binding]; other site 412022013226 N-terminal domain interface [polypeptide binding]; other site 412022013227 substrate binding pocket (H-site) [chemical binding]; other site 412022013228 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 412022013229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022013230 substrate binding pocket [chemical binding]; other site 412022013231 membrane-bound complex binding site; other site 412022013232 hinge residues; other site 412022013233 Fatty acid desaturase; Region: FA_desaturase; pfam00487 412022013234 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 412022013235 putative di-iron ligands [ion binding]; other site 412022013236 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 412022013237 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 412022013238 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412022013239 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 412022013240 D-pathway; other site 412022013241 Putative water exit pathway; other site 412022013242 Binuclear center (heme o3/CuB) [ion binding]; other site 412022013243 K-pathway; other site 412022013244 Putative proton exit pathway; other site 412022013245 Low-spin heme (heme b) binding site [chemical binding]; other site 412022013246 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 412022013247 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 412022013248 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 412022013249 Hemerythrin; Region: Hemerythrin; cd12107 412022013250 Fe binding site [ion binding]; other site 412022013251 Transcriptional regulator; Region: Rrf2; cl17282 412022013252 Rrf2 family protein; Region: rrf2_super; TIGR00738 412022013253 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 412022013254 Domain of unknown function DUF59; Region: DUF59; cl00941 412022013255 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 412022013256 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 412022013257 trimerization site [polypeptide binding]; other site 412022013258 active site 412022013259 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 412022013260 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 412022013261 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022013262 catalytic residue [active] 412022013263 FeS assembly protein SufD; Region: sufD; TIGR01981 412022013264 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 412022013265 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 412022013266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022013267 Walker A/P-loop; other site 412022013268 ATP binding site [chemical binding]; other site 412022013269 ABC transporter signature motif; other site 412022013270 Walker B; other site 412022013271 D-loop; other site 412022013272 H-loop/switch region; other site 412022013273 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 412022013274 putative ABC transporter; Region: ycf24; CHL00085 412022013275 NnrS protein; Region: NnrS; pfam05940 412022013276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022013277 dimerization interface [polypeptide binding]; other site 412022013278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412022013279 dimer interface [polypeptide binding]; other site 412022013280 putative CheW interface [polypeptide binding]; other site 412022013281 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 412022013282 HemN C-terminal domain; Region: HemN_C; pfam06969 412022013283 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412022013284 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412022013285 ligand binding site [chemical binding]; other site 412022013286 flexible hinge region; other site 412022013287 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 412022013288 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 412022013289 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 412022013290 FMN binding site [chemical binding]; other site 412022013291 substrate binding site [chemical binding]; other site 412022013292 putative catalytic residue [active] 412022013293 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 412022013294 Peptidase family U32; Region: Peptidase_U32; pfam01136 412022013295 putative protease; Provisional; Region: PRK15447 412022013296 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 412022013297 SCP-2 sterol transfer family; Region: SCP2; cl01225 412022013298 DGC domain; Region: DGC; pfam08859 412022013299 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 412022013300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022013301 FeS/SAM binding site; other site 412022013302 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 412022013303 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 412022013304 Class III ribonucleotide reductase; Region: RNR_III; cd01675 412022013305 effector binding site; other site 412022013306 active site 412022013307 Zn binding site [ion binding]; other site 412022013308 NnrS protein; Region: NnrS; pfam05940 412022013309 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 412022013310 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 412022013311 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 412022013312 Fatty acid desaturase; Region: FA_desaturase; pfam00487 412022013313 Di-iron ligands [ion binding]; other site 412022013314 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 412022013315 DNA photolyase; Region: DNA_photolyase; pfam00875 412022013316 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 412022013317 ligand-binding site [chemical binding]; other site 412022013318 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 412022013319 Autoinducer binding domain; Region: Autoind_bind; pfam03472 412022013320 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022013321 DNA binding residues [nucleotide binding] 412022013322 dimerization interface [polypeptide binding]; other site 412022013323 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 412022013324 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 412022013325 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 412022013326 active sites [active] 412022013327 tetramer interface [polypeptide binding]; other site 412022013328 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 412022013329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022013330 DNA-binding site [nucleotide binding]; DNA binding site 412022013331 UTRA domain; Region: UTRA; pfam07702 412022013332 urocanate hydratase; Provisional; Region: PRK05414 412022013333 HutD; Region: HutD; pfam05962 412022013334 imidazolonepropionase; Validated; Region: PRK09356 412022013335 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 412022013336 active site 412022013337 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 412022013338 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 412022013339 active site 412022013340 N-formylglutamate amidohydrolase; Region: FGase; cl01522 412022013341 Peptidase C26; Region: Peptidase_C26; pfam07722 412022013342 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 412022013343 catalytic triad [active] 412022013344 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 412022013345 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 412022013346 Transposase; Region: HTH_Tnp_1; pfam01527 412022013347 HTH-like domain; Region: HTH_21; pfam13276 412022013348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022013349 Integrase core domain; Region: rve; pfam00665 412022013350 Integrase core domain; Region: rve_3; pfam13683 412022013351 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 412022013352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022013353 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 412022013354 substrate binding site [chemical binding]; other site 412022013355 dimerization interface [polypeptide binding]; other site 412022013356 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 412022013357 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022013358 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412022013359 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 412022013360 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 412022013361 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 412022013362 Active Sites [active] 412022013363 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 412022013364 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 412022013365 Active Sites [active] 412022013366 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 412022013367 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 412022013368 CysD dimerization site [polypeptide binding]; other site 412022013369 G1 box; other site 412022013370 putative GEF interaction site [polypeptide binding]; other site 412022013371 GTP/Mg2+ binding site [chemical binding]; other site 412022013372 Switch I region; other site 412022013373 G2 box; other site 412022013374 G3 box; other site 412022013375 Switch II region; other site 412022013376 G4 box; other site 412022013377 G5 box; other site 412022013378 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 412022013379 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 412022013380 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 412022013381 active site 412022013382 SAM binding site [chemical binding]; other site 412022013383 homodimer interface [polypeptide binding]; other site 412022013384 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 412022013385 putative active site [active] 412022013386 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 412022013387 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412022013388 Predicted permeases [General function prediction only]; Region: COG0795 412022013389 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412022013390 multifunctional aminopeptidase A; Provisional; Region: PRK00913 412022013391 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 412022013392 interface (dimer of trimers) [polypeptide binding]; other site 412022013393 Substrate-binding/catalytic site; other site 412022013394 Zn-binding sites [ion binding]; other site 412022013395 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 412022013396 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 412022013397 Cytochrome c; Region: Cytochrom_C; cl11414 412022013398 Transposase domain (DUF772); Region: DUF772; pfam05598 412022013399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022013400 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022013401 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 412022013402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022013403 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 412022013404 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 412022013405 putative dimerization interface [polypeptide binding]; other site 412022013406 putative substrate binding pocket [chemical binding]; other site 412022013407 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 412022013408 Protein of unknown function (DUF541); Region: SIMPL; cl01077 412022013409 Uncharacterized conserved protein [Function unknown]; Region: COG2947 412022013410 Cell division protein ZapA; Region: ZapA; pfam05164 412022013411 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 412022013412 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 412022013413 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 412022013414 N-terminal plug; other site 412022013415 ligand-binding site [chemical binding]; other site 412022013416 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412022013417 ABC-ATPase subunit interface; other site 412022013418 dimer interface [polypeptide binding]; other site 412022013419 putative PBP binding regions; other site 412022013420 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412022013421 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412022013422 Walker A/P-loop; other site 412022013423 ATP binding site [chemical binding]; other site 412022013424 Q-loop/lid; other site 412022013425 ABC transporter signature motif; other site 412022013426 Walker B; other site 412022013427 D-loop; other site 412022013428 H-loop/switch region; other site 412022013429 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 412022013430 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 412022013431 putative dimer interface [polypeptide binding]; other site 412022013432 active site pocket [active] 412022013433 putative cataytic base [active] 412022013434 cobalamin synthase; Reviewed; Region: cobS; PRK00235 412022013435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412022013436 catalytic core [active] 412022013437 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 412022013438 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 412022013439 cobalamin binding residues [chemical binding]; other site 412022013440 putative BtuC binding residues; other site 412022013441 dimer interface [polypeptide binding]; other site 412022013442 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 412022013443 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 412022013444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022013445 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 412022013446 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 412022013447 homotrimer interface [polypeptide binding]; other site 412022013448 Walker A motif; other site 412022013449 GTP binding site [chemical binding]; other site 412022013450 Walker B motif; other site 412022013451 cobyric acid synthase; Provisional; Region: PRK00784 412022013452 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 412022013453 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 412022013454 catalytic triad [active] 412022013455 DoxX; Region: DoxX; pfam07681 412022013456 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412022013457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412022013458 P-loop; other site 412022013459 Magnesium ion binding site [ion binding]; other site 412022013460 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 412022013461 tetramerization interface [polypeptide binding]; other site 412022013462 active site 412022013463 pantoate--beta-alanine ligase; Region: panC; TIGR00018 412022013464 Pantoate-beta-alanine ligase; Region: PanC; cd00560 412022013465 active site 412022013466 ATP-binding site [chemical binding]; other site 412022013467 pantoate-binding site; other site 412022013468 HXXH motif; other site 412022013469 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 412022013470 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 412022013471 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 412022013472 Surface antigen; Region: Bac_surface_Ag; pfam01103 412022013473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 412022013474 Family of unknown function (DUF490); Region: DUF490; pfam04357 412022013475 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 412022013476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022013477 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 412022013478 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 412022013479 active site 412022013480 HIGH motif; other site 412022013481 KMSKS motif; other site 412022013482 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 412022013483 tRNA binding surface [nucleotide binding]; other site 412022013484 anticodon binding site; other site 412022013485 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 412022013486 dimer interface [polypeptide binding]; other site 412022013487 putative tRNA-binding site [nucleotide binding]; other site 412022013488 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 412022013489 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412022013490 ligand binding site [chemical binding]; other site 412022013491 Domain of unknown function DUF59; Region: DUF59; pfam01883 412022013492 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 412022013493 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 412022013494 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 412022013495 E-class dimer interface [polypeptide binding]; other site 412022013496 P-class dimer interface [polypeptide binding]; other site 412022013497 active site 412022013498 Cu2+ binding site [ion binding]; other site 412022013499 Zn2+ binding site [ion binding]; other site 412022013500 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 412022013501 trimer interface [polypeptide binding]; other site 412022013502 active site 412022013503 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 412022013504 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 412022013505 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412022013506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022013507 catalytic residue [active] 412022013508 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 412022013509 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 412022013510 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 412022013511 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 412022013512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022013513 motif II; other site 412022013514 argininosuccinate lyase; Provisional; Region: PRK00855 412022013515 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 412022013516 active sites [active] 412022013517 tetramer interface [polypeptide binding]; other site 412022013518 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 412022013519 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 412022013520 PapC C-terminal domain; Region: PapC_C; pfam13953 412022013521 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 412022013522 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 412022013523 Uncharacterized secreted protein [Function unknown]; Region: COG5430 412022013524 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022013525 Spore Coat Protein U domain; Region: SCPU; pfam05229 412022013526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412022013527 sequence-specific DNA binding site [nucleotide binding]; other site 412022013528 salt bridge; other site 412022013529 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412022013530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022013531 S-adenosylmethionine binding site [chemical binding]; other site 412022013532 Transposase domain (DUF772); Region: DUF772; pfam05598 412022013533 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022013534 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022013535 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 412022013536 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 412022013537 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 412022013538 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 412022013539 domain interfaces; other site 412022013540 active site 412022013541 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 412022013542 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 412022013543 active site 412022013544 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 412022013545 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 412022013546 HemY protein N-terminus; Region: HemY_N; pfam07219 412022013547 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 412022013548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022013549 putative substrate translocation pore; other site 412022013550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412022013551 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 412022013552 NAD(P) binding site [chemical binding]; other site 412022013553 active site 412022013554 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412022013555 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 412022013556 NAD(P) binding site [chemical binding]; other site 412022013557 catalytic residues [active] 412022013558 catalytic residues [active] 412022013559 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 412022013560 dimer interface [polypeptide binding]; other site 412022013561 substrate binding site [chemical binding]; other site 412022013562 metal binding sites [ion binding]; metal-binding site 412022013563 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 412022013564 GIY-YIG motif/motif A; other site 412022013565 putative active site [active] 412022013566 putative metal binding site [ion binding]; other site 412022013567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 412022013568 Protein of unknown function, DUF482; Region: DUF482; pfam04339 412022013569 NAD synthetase; Provisional; Region: PRK13981 412022013570 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 412022013571 multimer interface [polypeptide binding]; other site 412022013572 active site 412022013573 catalytic triad [active] 412022013574 protein interface 1 [polypeptide binding]; other site 412022013575 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 412022013576 homodimer interface [polypeptide binding]; other site 412022013577 NAD binding pocket [chemical binding]; other site 412022013578 ATP binding pocket [chemical binding]; other site 412022013579 Mg binding site [ion binding]; other site 412022013580 active-site loop [active] 412022013581 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 412022013582 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412022013583 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022013584 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022013585 trimer interface [polypeptide binding]; other site 412022013586 eyelet of channel; other site 412022013587 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 412022013588 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412022013589 Walker A/P-loop; other site 412022013590 ATP binding site [chemical binding]; other site 412022013591 Q-loop/lid; other site 412022013592 ABC transporter signature motif; other site 412022013593 Walker B; other site 412022013594 D-loop; other site 412022013595 H-loop/switch region; other site 412022013596 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022013597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022013598 dimer interface [polypeptide binding]; other site 412022013599 conserved gate region; other site 412022013600 putative PBP binding loops; other site 412022013601 ABC-ATPase subunit interface; other site 412022013602 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412022013603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022013604 dimer interface [polypeptide binding]; other site 412022013605 conserved gate region; other site 412022013606 putative PBP binding loops; other site 412022013607 ABC-ATPase subunit interface; other site 412022013608 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 412022013609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412022013610 substrate binding pocket [chemical binding]; other site 412022013611 membrane-bound complex binding site; other site 412022013612 hinge residues; other site 412022013613 Pirin-related protein [General function prediction only]; Region: COG1741 412022013614 Pirin; Region: Pirin; pfam02678 412022013615 Pirin-related protein [General function prediction only]; Region: COG1741 412022013616 osmolarity response regulator; Provisional; Region: ompR; PRK09468 412022013617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022013618 active site 412022013619 phosphorylation site [posttranslational modification] 412022013620 intermolecular recognition site; other site 412022013621 dimerization interface [polypeptide binding]; other site 412022013622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022013623 DNA binding site [nucleotide binding] 412022013624 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 412022013625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022013626 dimer interface [polypeptide binding]; other site 412022013627 phosphorylation site [posttranslational modification] 412022013628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022013629 ATP binding site [chemical binding]; other site 412022013630 Mg2+ binding site [ion binding]; other site 412022013631 G-X-G motif; other site 412022013632 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 412022013633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022013634 dimer interface [polypeptide binding]; other site 412022013635 conserved gate region; other site 412022013636 putative PBP binding loops; other site 412022013637 ABC-ATPase subunit interface; other site 412022013638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022013639 dimer interface [polypeptide binding]; other site 412022013640 conserved gate region; other site 412022013641 putative PBP binding loops; other site 412022013642 ABC-ATPase subunit interface; other site 412022013643 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412022013644 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412022013645 Walker A/P-loop; other site 412022013646 ATP binding site [chemical binding]; other site 412022013647 Q-loop/lid; other site 412022013648 ABC transporter signature motif; other site 412022013649 Walker B; other site 412022013650 D-loop; other site 412022013651 H-loop/switch region; other site 412022013652 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 412022013653 HTH-like domain; Region: HTH_21; pfam13276 412022013654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022013655 Integrase core domain; Region: rve; pfam00665 412022013656 Integrase core domain; Region: rve_3; pfam13683 412022013657 Transposase; Region: HTH_Tnp_1; pfam01527 412022013658 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 412022013659 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 412022013660 active site 412022013661 homotetramer interface [polypeptide binding]; other site 412022013662 Predicted ATPase [General function prediction only]; Region: COG3911 412022013663 AAA domain; Region: AAA_28; pfam13521 412022013664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022013665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022013666 putative substrate translocation pore; other site 412022013667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 412022013668 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 412022013669 substrate binding site [chemical binding]; other site 412022013670 ecotin; Provisional; Region: PRK03719 412022013671 secondary substrate binding site; other site 412022013672 primary substrate binding site; other site 412022013673 inhibition loop; other site 412022013674 dimerization interface [polypeptide binding]; other site 412022013675 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412022013676 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412022013677 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 412022013678 Transposase; Region: HTH_Tnp_1; pfam01527 412022013679 HTH-like domain; Region: HTH_21; pfam13276 412022013680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022013681 Integrase core domain; Region: rve; pfam00665 412022013682 Integrase core domain; Region: rve_3; pfam13683 412022013683 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 412022013684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412022013685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412022013686 dimerization interface [polypeptide binding]; other site 412022013687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412022013688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412022013689 active site 412022013690 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 412022013691 CoA-transferase family III; Region: CoA_transf_3; pfam02515 412022013692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022013693 metabolite-proton symporter; Region: 2A0106; TIGR00883 412022013694 putative substrate translocation pore; other site 412022013695 oxidative damage protection protein; Provisional; Region: PRK05408 412022013696 N-acetylglutamate synthase; Validated; Region: PRK05279 412022013697 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 412022013698 putative feedback inhibition sensing region; other site 412022013699 putative nucleotide binding site [chemical binding]; other site 412022013700 putative substrate binding site [chemical binding]; other site 412022013701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022013702 Coenzyme A binding pocket [chemical binding]; other site 412022013703 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 412022013704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022013705 ATP binding site [chemical binding]; other site 412022013706 putative Mg++ binding site [ion binding]; other site 412022013707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022013708 nucleotide binding region [chemical binding]; other site 412022013709 ATP-binding site [chemical binding]; other site 412022013710 Helicase associated domain (HA2); Region: HA2; pfam04408 412022013711 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 412022013712 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 412022013713 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 412022013714 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 412022013715 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 412022013716 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 412022013717 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 412022013718 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 412022013719 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 412022013720 putative MPT binding site; other site 412022013721 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 412022013722 active site residue [active] 412022013723 glutamine synthetase; Provisional; Region: glnA; PRK09469 412022013724 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 412022013725 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 412022013726 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 412022013727 PAS domain; Region: PAS; smart00091 412022013728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022013729 dimer interface [polypeptide binding]; other site 412022013730 phosphorylation site [posttranslational modification] 412022013731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022013732 ATP binding site [chemical binding]; other site 412022013733 Mg2+ binding site [ion binding]; other site 412022013734 G-X-G motif; other site 412022013735 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 412022013736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022013737 active site 412022013738 phosphorylation site [posttranslational modification] 412022013739 intermolecular recognition site; other site 412022013740 dimerization interface [polypeptide binding]; other site 412022013741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022013742 Walker A motif; other site 412022013743 ATP binding site [chemical binding]; other site 412022013744 Walker B motif; other site 412022013745 arginine finger; other site 412022013746 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412022013747 Transposase domain (DUF772); Region: DUF772; pfam05598 412022013748 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022013749 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022013750 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 412022013751 putative catalytic site [active] 412022013752 putative phosphate binding site [ion binding]; other site 412022013753 active site 412022013754 metal binding site A [ion binding]; metal-binding site 412022013755 DNA binding site [nucleotide binding] 412022013756 putative AP binding site [nucleotide binding]; other site 412022013757 putative metal binding site B [ion binding]; other site 412022013758 transcriptional regulator NarL; Provisional; Region: PRK10651 412022013759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022013760 active site 412022013761 phosphorylation site [posttranslational modification] 412022013762 intermolecular recognition site; other site 412022013763 dimerization interface [polypeptide binding]; other site 412022013764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022013765 DNA binding residues [nucleotide binding] 412022013766 dimerization interface [polypeptide binding]; other site 412022013767 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 412022013768 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 412022013769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412022013770 dimerization interface [polypeptide binding]; other site 412022013771 GAF domain; Region: GAF; pfam01590 412022013772 Histidine kinase; Region: HisKA_3; pfam07730 412022013773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022013774 ATP binding site [chemical binding]; other site 412022013775 Mg2+ binding site [ion binding]; other site 412022013776 G-X-G motif; other site 412022013777 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 412022013778 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 412022013779 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 412022013780 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 412022013781 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 412022013782 [4Fe-4S] binding site [ion binding]; other site 412022013783 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022013784 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022013785 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022013786 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 412022013787 molybdopterin cofactor binding site; other site 412022013788 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 412022013789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022013790 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 412022013791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022013792 putative substrate translocation pore; other site 412022013793 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 412022013794 active site 412022013795 DNA polymerase IV; Validated; Region: PRK02406 412022013796 DNA binding site [nucleotide binding] 412022013797 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 412022013798 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 412022013799 active site 412022013800 Zn binding site [ion binding]; other site 412022013801 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 412022013802 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 412022013803 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 412022013804 homodimer interface [polypeptide binding]; other site 412022013805 NADP binding site [chemical binding]; other site 412022013806 substrate binding site [chemical binding]; other site 412022013807 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 412022013808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022013809 active site 412022013810 phosphorylation site [posttranslational modification] 412022013811 intermolecular recognition site; other site 412022013812 dimerization interface [polypeptide binding]; other site 412022013813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022013814 DNA binding residues [nucleotide binding] 412022013815 dimerization interface [polypeptide binding]; other site 412022013816 PAS domain S-box; Region: sensory_box; TIGR00229 412022013817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412022013818 putative active site [active] 412022013819 heme pocket [chemical binding]; other site 412022013820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022013821 dimer interface [polypeptide binding]; other site 412022013822 phosphorylation site [posttranslational modification] 412022013823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022013824 ATP binding site [chemical binding]; other site 412022013825 Mg2+ binding site [ion binding]; other site 412022013826 G-X-G motif; other site 412022013827 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 412022013828 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 412022013829 dimer interface [polypeptide binding]; other site 412022013830 TPP-binding site [chemical binding]; other site 412022013831 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 412022013832 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412022013833 E3 interaction surface; other site 412022013834 lipoyl attachment site [posttranslational modification]; other site 412022013835 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412022013836 E3 interaction surface; other site 412022013837 lipoyl attachment site [posttranslational modification]; other site 412022013838 e3 binding domain; Region: E3_binding; pfam02817 412022013839 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412022013840 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412022013841 E3 interaction surface; other site 412022013842 lipoyl attachment site [posttranslational modification]; other site 412022013843 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 412022013844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412022013845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412022013846 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412022013847 Transposase domain (DUF772); Region: DUF772; pfam05598 412022013848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022013849 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022013850 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412022013851 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412022013852 Phasin protein; Region: Phasin_2; pfam09361 412022013853 Transposase domain (DUF772); Region: DUF772; pfam05598 412022013854 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022013855 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022013856 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412022013857 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412022013858 Bacterial transcriptional regulator; Region: IclR; pfam01614 412022013859 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412022013860 Cysteine-rich domain; Region: CCG; pfam02754 412022013861 Cysteine-rich domain; Region: CCG; pfam02754 412022013862 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 412022013863 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 412022013864 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412022013865 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 412022013866 Low molecular weight phosphatase family; Region: LMWPc; cd00115 412022013867 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 412022013868 active site 412022013869 Predicted transcriptional regulator [Transcription]; Region: COG1959 412022013870 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 412022013871 cysteine desulfurase; Provisional; Region: PRK14012 412022013872 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 412022013873 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022013874 catalytic residue [active] 412022013875 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 412022013876 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 412022013877 trimerization site [polypeptide binding]; other site 412022013878 active site 412022013879 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412022013880 co-chaperone HscB; Provisional; Region: hscB; PRK03578 412022013881 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412022013882 HSP70 interaction site [polypeptide binding]; other site 412022013883 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 412022013884 chaperone protein HscA; Provisional; Region: hscA; PRK05183 412022013885 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 412022013886 nucleotide binding site [chemical binding]; other site 412022013887 putative NEF/HSP70 interaction site [polypeptide binding]; other site 412022013888 SBD interface [polypeptide binding]; other site 412022013889 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 412022013890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412022013891 catalytic loop [active] 412022013892 iron binding site [ion binding]; other site 412022013893 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 412022013894 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 412022013895 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 412022013896 dimer interface [polypeptide binding]; other site 412022013897 putative anticodon binding site; other site 412022013898 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 412022013899 motif 1; other site 412022013900 active site 412022013901 motif 2; other site 412022013902 motif 3; other site 412022013903 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412022013904 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 412022013905 RF-1 domain; Region: RF-1; pfam00472 412022013906 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 412022013907 DHH family; Region: DHH; pfam01368 412022013908 DHHA1 domain; Region: DHHA1; pfam02272 412022013909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 412022013910 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 412022013911 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412022013912 FtsX-like permease family; Region: FtsX; pfam02687 412022013913 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 412022013914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412022013915 Walker A/P-loop; other site 412022013916 ATP binding site [chemical binding]; other site 412022013917 Q-loop/lid; other site 412022013918 ABC transporter signature motif; other site 412022013919 Walker B; other site 412022013920 D-loop; other site 412022013921 H-loop/switch region; other site 412022013922 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412022013923 active site 412022013924 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 412022013925 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 412022013926 Competence protein; Region: Competence; pfam03772 412022013927 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 412022013928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412022013929 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022013930 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 412022013931 nucleophilic elbow; other site 412022013932 catalytic triad; other site 412022013933 CTP synthetase; Validated; Region: pyrG; PRK05380 412022013934 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 412022013935 Catalytic site [active] 412022013936 active site 412022013937 UTP binding site [chemical binding]; other site 412022013938 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 412022013939 active site 412022013940 putative oxyanion hole; other site 412022013941 catalytic triad [active] 412022013942 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 412022013943 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412022013944 enolase; Provisional; Region: eno; PRK00077 412022013945 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 412022013946 dimer interface [polypeptide binding]; other site 412022013947 metal binding site [ion binding]; metal-binding site 412022013948 substrate binding pocket [chemical binding]; other site 412022013949 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 412022013950 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 412022013951 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 412022013952 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 412022013953 dimerization interface [polypeptide binding]; other site 412022013954 domain crossover interface; other site 412022013955 redox-dependent activation switch; other site 412022013956 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 412022013957 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 412022013958 trimer interface [polypeptide binding]; other site 412022013959 putative metal binding site [ion binding]; other site 412022013960 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 412022013961 dinuclear metal binding motif [ion binding]; other site 412022013962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412022013963 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412022013964 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 412022013965 catalytic site [active] 412022013966 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 412022013967 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 412022013968 active site 412022013969 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 412022013970 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 412022013971 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 412022013972 Peptidase family M50; Region: Peptidase_M50; pfam02163 412022013973 active site 412022013974 putative substrate binding region [chemical binding]; other site 412022013975 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 412022013976 active site 412022013977 HIGH motif; other site 412022013978 dimer interface [polypeptide binding]; other site 412022013979 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412022013980 active site 412022013981 KMSKS motif; other site 412022013982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412022013983 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 412022013984 dihydrodipicolinate synthase; Region: dapA; TIGR00674 412022013985 dimer interface [polypeptide binding]; other site 412022013986 active site 412022013987 catalytic residue [active] 412022013988 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 412022013989 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 412022013990 Uncharacterized conserved protein [Function unknown]; Region: COG2850 412022013991 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 412022013992 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 412022013993 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 412022013994 MutS domain I; Region: MutS_I; pfam01624 412022013995 MutS domain II; Region: MutS_II; pfam05188 412022013996 MutS domain III; Region: MutS_III; pfam05192 412022013997 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 412022013998 Walker A/P-loop; other site 412022013999 ATP binding site [chemical binding]; other site 412022014000 Q-loop/lid; other site 412022014001 ABC transporter signature motif; other site 412022014002 Walker B; other site 412022014003 D-loop; other site 412022014004 H-loop/switch region; other site 412022014005 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 412022014006 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 412022014007 active site 412022014008 dimerization interface [polypeptide binding]; other site 412022014009 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 412022014010 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 412022014011 serine O-acetyltransferase; Region: cysE; TIGR01172 412022014012 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 412022014013 trimer interface [polypeptide binding]; other site 412022014014 active site 412022014015 substrate binding site [chemical binding]; other site 412022014016 CoA binding site [chemical binding]; other site 412022014017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022014018 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 412022014019 putative active site [active] 412022014020 putative metal binding site [ion binding]; other site 412022014021 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 412022014022 substrate binding site [chemical binding]; other site 412022014023 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 412022014024 substrate binding site [chemical binding]; other site 412022014025 TPR repeat; Region: TPR_11; pfam13414 412022014026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022014027 binding surface 412022014028 TPR motif; other site 412022014029 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 412022014030 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412022014031 active site 412022014032 HIGH motif; other site 412022014033 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412022014034 KMSKS motif; other site 412022014035 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 412022014036 tRNA binding surface [nucleotide binding]; other site 412022014037 anticodon binding site; other site 412022014038 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412022014039 endonuclease III; Region: ENDO3c; smart00478 412022014040 minor groove reading motif; other site 412022014041 helix-hairpin-helix signature motif; other site 412022014042 substrate binding pocket [chemical binding]; other site 412022014043 active site 412022014044 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 412022014045 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 412022014046 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 412022014047 Ligand Binding Site [chemical binding]; other site 412022014048 TilS substrate binding domain; Region: TilS; pfam09179 412022014049 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 412022014050 aspartate kinase; Reviewed; Region: PRK06635 412022014051 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 412022014052 putative nucleotide binding site [chemical binding]; other site 412022014053 putative catalytic residues [active] 412022014054 putative Mg ion binding site [ion binding]; other site 412022014055 putative aspartate binding site [chemical binding]; other site 412022014056 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 412022014057 putative allosteric regulatory site; other site 412022014058 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 412022014059 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 412022014060 active site 412022014061 catalytic triad [active] 412022014062 oxyanion hole [active] 412022014063 Autotransporter beta-domain; Region: Autotransporter; smart00869 412022014064 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 412022014065 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412022014066 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412022014067 HlyD family secretion protein; Region: HlyD_3; pfam13437 412022014068 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 412022014069 ligand-binding site [chemical binding]; other site 412022014070 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022014071 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022014072 acyl-activating enzyme (AAE) consensus motif; other site 412022014073 AMP binding site [chemical binding]; other site 412022014074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022014075 Transmembrane secretion effector; Region: MFS_3; pfam05977 412022014076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022014077 putative substrate translocation pore; other site 412022014078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 412022014079 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 412022014080 Condensation domain; Region: Condensation; pfam00668 412022014081 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 412022014082 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412022014083 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022014084 acyl-activating enzyme (AAE) consensus motif; other site 412022014085 AMP binding site [chemical binding]; other site 412022014086 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022014087 Condensation domain; Region: Condensation; pfam00668 412022014088 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 412022014089 Condensation domain; Region: Condensation; pfam00668 412022014090 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412022014091 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412022014092 acyl-activating enzyme (AAE) consensus motif; other site 412022014093 AMP binding site [chemical binding]; other site 412022014094 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412022014095 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 412022014096 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 412022014097 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 412022014098 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412022014099 active site 412022014100 iron coordination sites [ion binding]; other site 412022014101 substrate binding pocket [chemical binding]; other site 412022014102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022014103 S-adenosylmethionine binding site [chemical binding]; other site 412022014104 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 412022014105 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 412022014106 TPP-binding site [chemical binding]; other site 412022014107 dimer interface [polypeptide binding]; other site 412022014108 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412022014109 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 412022014110 PYR/PP interface [polypeptide binding]; other site 412022014111 dimer interface [polypeptide binding]; other site 412022014112 TPP binding site [chemical binding]; other site 412022014113 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 412022014114 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 412022014115 phosphoserine aminotransferase; Provisional; Region: PRK12462 412022014116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412022014117 catalytic residue [active] 412022014118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412022014119 active site 412022014120 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 412022014121 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 412022014122 Active Sites [active] 412022014123 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 412022014124 G1 box; other site 412022014125 GTP/Mg2+ binding site [chemical binding]; other site 412022014126 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 412022014127 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 412022014128 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412022014129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022014130 catalytic residue [active] 412022014131 dimer interface [polypeptide binding]; other site 412022014132 argininosuccinate lyase; Provisional; Region: PRK02186 412022014133 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 412022014134 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 412022014135 active sites [active] 412022014136 tetramer interface [polypeptide binding]; other site 412022014137 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 412022014138 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412022014139 active site 412022014140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412022014141 Ferredoxin [Energy production and conversion]; Region: COG1146 412022014142 4Fe-4S binding domain; Region: Fer4; cl02805 412022014143 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 412022014144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412022014145 FeS/SAM binding site; other site 412022014146 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 412022014147 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 412022014148 FAD binding pocket [chemical binding]; other site 412022014149 FAD binding motif [chemical binding]; other site 412022014150 phosphate binding motif [ion binding]; other site 412022014151 beta-alpha-beta structure motif; other site 412022014152 NAD binding pocket [chemical binding]; other site 412022014153 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 412022014154 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 412022014155 putative [Fe4-S4] binding site [ion binding]; other site 412022014156 putative molybdopterin cofactor binding site [chemical binding]; other site 412022014157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412022014158 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 412022014159 putative molybdopterin cofactor binding site; other site 412022014160 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 412022014161 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 412022014162 NAD binding site [chemical binding]; other site 412022014163 homotetramer interface [polypeptide binding]; other site 412022014164 homodimer interface [polypeptide binding]; other site 412022014165 substrate binding site [chemical binding]; other site 412022014166 active site 412022014167 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412022014168 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 412022014169 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 412022014170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022014171 dimer interface [polypeptide binding]; other site 412022014172 conserved gate region; other site 412022014173 putative PBP binding loops; other site 412022014174 ABC-ATPase subunit interface; other site 412022014175 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 412022014176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412022014177 dimer interface [polypeptide binding]; other site 412022014178 conserved gate region; other site 412022014179 putative PBP binding loops; other site 412022014180 ABC-ATPase subunit interface; other site 412022014181 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 412022014182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022014183 Walker A/P-loop; other site 412022014184 ATP binding site [chemical binding]; other site 412022014185 Q-loop/lid; other site 412022014186 ABC transporter signature motif; other site 412022014187 Walker B; other site 412022014188 D-loop; other site 412022014189 H-loop/switch region; other site 412022014190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022014191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412022014192 Walker A/P-loop; other site 412022014193 ATP binding site [chemical binding]; other site 412022014194 Q-loop/lid; other site 412022014195 ABC transporter signature motif; other site 412022014196 Walker B; other site 412022014197 D-loop; other site 412022014198 H-loop/switch region; other site 412022014199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412022014200 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 412022014201 NlpC/P60 family; Region: NLPC_P60; pfam00877 412022014202 hypothetical protein; Provisional; Region: PRK10279 412022014203 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 412022014204 nucleophile elbow; other site 412022014205 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 412022014206 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412022014207 active site 412022014208 HIGH motif; other site 412022014209 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412022014210 active site 412022014211 KMSKS motif; other site 412022014212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022014213 Coenzyme A binding pocket [chemical binding]; other site 412022014214 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 412022014215 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 412022014216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022014217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412022014218 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 412022014219 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 412022014220 putative active site pocket [active] 412022014221 dimerization interface [polypeptide binding]; other site 412022014222 putative catalytic residue [active] 412022014223 malate synthase A; Region: malate_syn_A; TIGR01344 412022014224 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 412022014225 active site 412022014226 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 412022014227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412022014228 motif II; other site 412022014229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412022014230 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 412022014231 putative effector binding pocket; other site 412022014232 dimerization interface [polypeptide binding]; other site 412022014233 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412022014234 Ligand Binding Site [chemical binding]; other site 412022014235 isocitrate lyase; Provisional; Region: PRK15063 412022014236 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 412022014237 tetramer interface [polypeptide binding]; other site 412022014238 active site 412022014239 Mg2+/Mn2+ binding site [ion binding]; other site 412022014240 Transposase domain (DUF772); Region: DUF772; pfam05598 412022014241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022014242 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022014243 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412022014244 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412022014245 ATP binding site [chemical binding]; other site 412022014246 Mg++ binding site [ion binding]; other site 412022014247 motif III; other site 412022014248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022014249 nucleotide binding region [chemical binding]; other site 412022014250 ATP-binding site [chemical binding]; other site 412022014251 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 412022014252 acyl-CoA binding pocket [chemical binding]; other site 412022014253 CoA binding site [chemical binding]; other site 412022014254 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 412022014255 Glycoprotease family; Region: Peptidase_M22; pfam00814 412022014256 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 412022014257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022014258 Coenzyme A binding pocket [chemical binding]; other site 412022014259 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 412022014260 Fe-S cluster binding site [ion binding]; other site 412022014261 active site 412022014262 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 412022014263 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 412022014264 dimer interface [polypeptide binding]; other site 412022014265 substrate binding site [chemical binding]; other site 412022014266 ATP binding site [chemical binding]; other site 412022014267 lysophospholipid transporter LplT; Provisional; Region: PRK11195 412022014268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412022014269 alanine racemase; Reviewed; Region: dadX; PRK03646 412022014270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 412022014271 active site 412022014272 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412022014273 substrate binding site [chemical binding]; other site 412022014274 catalytic residues [active] 412022014275 dimer interface [polypeptide binding]; other site 412022014276 DNA repair protein RadA; Provisional; Region: PRK11823 412022014277 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 412022014278 Walker A motif/ATP binding site; other site 412022014279 ATP binding site [chemical binding]; other site 412022014280 Walker B motif; other site 412022014281 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 412022014282 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 412022014283 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 412022014284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022014285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022014286 ABC transporter; Region: ABC_tran_2; pfam12848 412022014287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412022014288 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 412022014289 catalytic residues [active] 412022014290 dimer interface [polypeptide binding]; other site 412022014291 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 412022014292 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 412022014293 putative active site [active] 412022014294 catalytic site [active] 412022014295 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 412022014296 putative active site [active] 412022014297 catalytic site [active] 412022014298 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 412022014299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412022014300 S-adenosylmethionine binding site [chemical binding]; other site 412022014301 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 412022014302 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 412022014303 metal binding site [ion binding]; metal-binding site 412022014304 dimer interface [polypeptide binding]; other site 412022014305 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 412022014306 ArsC family; Region: ArsC; pfam03960 412022014307 putative catalytic residues [active] 412022014308 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 412022014309 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 412022014310 trimer interface [polypeptide binding]; other site 412022014311 active site 412022014312 substrate binding site [chemical binding]; other site 412022014313 CoA binding site [chemical binding]; other site 412022014314 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 412022014315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412022014316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022014317 homodimer interface [polypeptide binding]; other site 412022014318 catalytic residue [active] 412022014319 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022014320 EamA-like transporter family; Region: EamA; pfam00892 412022014321 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 412022014322 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 412022014323 Walker A/P-loop; other site 412022014324 ATP binding site [chemical binding]; other site 412022014325 Q-loop/lid; other site 412022014326 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 412022014327 Q-loop/lid; other site 412022014328 ABC transporter signature motif; other site 412022014329 Walker B; other site 412022014330 D-loop; other site 412022014331 H-loop/switch region; other site 412022014332 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 412022014333 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 412022014334 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 412022014335 nucleotide binding pocket [chemical binding]; other site 412022014336 K-X-D-G motif; other site 412022014337 catalytic site [active] 412022014338 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 412022014339 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 412022014340 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 412022014341 Dimer interface [polypeptide binding]; other site 412022014342 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412022014343 active site 412022014344 catalytic residues [active] 412022014345 metal binding site [ion binding]; metal-binding site 412022014346 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412022014347 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412022014348 RNA binding surface [nucleotide binding]; other site 412022014349 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 412022014350 active site 412022014351 PII uridylyl-transferase; Provisional; Region: PRK03059 412022014352 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 412022014353 metal binding triad; other site 412022014354 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 412022014355 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412022014356 Zn2+ binding site [ion binding]; other site 412022014357 Mg2+ binding site [ion binding]; other site 412022014358 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 412022014359 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 412022014360 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412022014361 active site 412022014362 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 412022014363 rRNA interaction site [nucleotide binding]; other site 412022014364 S8 interaction site; other site 412022014365 putative laminin-1 binding site; other site 412022014366 elongation factor Ts; Provisional; Region: tsf; PRK09377 412022014367 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 412022014368 Elongation factor TS; Region: EF_TS; pfam00889 412022014369 Elongation factor TS; Region: EF_TS; pfam00889 412022014370 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 412022014371 putative nucleotide binding site [chemical binding]; other site 412022014372 uridine monophosphate binding site [chemical binding]; other site 412022014373 homohexameric interface [polypeptide binding]; other site 412022014374 ribosome recycling factor; Reviewed; Region: frr; PRK00083 412022014375 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 412022014376 hinge region; other site 412022014377 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 412022014378 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 412022014379 catalytic residue [active] 412022014380 putative FPP diphosphate binding site; other site 412022014381 putative FPP binding hydrophobic cleft; other site 412022014382 dimer interface [polypeptide binding]; other site 412022014383 putative IPP diphosphate binding site; other site 412022014384 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 412022014385 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 412022014386 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 412022014387 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 412022014388 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 412022014389 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 412022014390 zinc metallopeptidase RseP; Provisional; Region: PRK10779 412022014391 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 412022014392 active site 412022014393 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412022014394 protein binding site [polypeptide binding]; other site 412022014395 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 412022014396 putative substrate binding region [chemical binding]; other site 412022014397 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 412022014398 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412022014399 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412022014400 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412022014401 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412022014402 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412022014403 Surface antigen; Region: Bac_surface_Ag; pfam01103 412022014404 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 412022014405 periplasmic chaperone; Provisional; Region: PRK10780 412022014406 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 412022014407 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 412022014408 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 412022014409 trimer interface [polypeptide binding]; other site 412022014410 active site 412022014411 UDP-GlcNAc binding site [chemical binding]; other site 412022014412 lipid binding site [chemical binding]; lipid-binding site 412022014413 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 412022014414 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 412022014415 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 412022014416 active site 412022014417 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 412022014418 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 412022014419 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 412022014420 RNA/DNA hybrid binding site [nucleotide binding]; other site 412022014421 active site 412022014422 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 412022014423 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412022014424 PEP synthetase regulatory protein; Provisional; Region: PRK05339 412022014425 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 412022014426 peptidase domain interface [polypeptide binding]; other site 412022014427 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 412022014428 active site 412022014429 catalytic triad [active] 412022014430 calcium binding site [ion binding]; other site 412022014431 Phytochelatin synthase; Region: Phytochelatin; pfam05023 412022014432 phosphoenolpyruvate synthase; Validated; Region: PRK06464 412022014433 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 412022014434 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 412022014435 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 412022014436 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 412022014437 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 412022014438 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 412022014439 SmpB-tmRNA interface; other site 412022014440 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 412022014441 putative coenzyme Q binding site [chemical binding]; other site 412022014442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 412022014443 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412022014444 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 412022014445 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 412022014446 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 412022014447 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412022014448 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 412022014449 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 412022014450 active site 412022014451 GMP synthase; Reviewed; Region: guaA; PRK00074 412022014452 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 412022014453 AMP/PPi binding site [chemical binding]; other site 412022014454 candidate oxyanion hole; other site 412022014455 catalytic triad [active] 412022014456 potential glutamine specificity residues [chemical binding]; other site 412022014457 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 412022014458 ATP Binding subdomain [chemical binding]; other site 412022014459 Ligand Binding sites [chemical binding]; other site 412022014460 Dimerization subdomain; other site 412022014461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412022014462 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 412022014463 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 412022014464 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 412022014465 nucleoside/Zn binding site; other site 412022014466 dimer interface [polypeptide binding]; other site 412022014467 catalytic motif [active] 412022014468 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 412022014469 dimer interface [polypeptide binding]; other site 412022014470 catalytic triad [active] 412022014471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 412022014472 Transposase; Region: DDE_Tnp_ISL3; pfam01610 412022014473 Transcriptional regulators [Transcription]; Region: GntR; COG1802 412022014474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412022014475 DNA-binding site [nucleotide binding]; DNA binding site 412022014476 FCD domain; Region: FCD; pfam07729 412022014477 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 412022014478 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 412022014479 Na binding site [ion binding]; other site 412022014480 putative substrate binding site [chemical binding]; other site 412022014481 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 412022014482 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 412022014483 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 412022014484 active site 412022014485 catalytic site [active] 412022014486 tetramer interface [polypeptide binding]; other site 412022014487 OHCU decarboxylase; Region: UHCUDC; TIGR03164 412022014488 allantoicase; Provisional; Region: PRK13257 412022014489 Allantoicase repeat; Region: Allantoicase; pfam03561 412022014490 Allantoicase repeat; Region: Allantoicase; pfam03561 412022014491 ureidoglycolate hydrolase; Provisional; Region: PRK03606 412022014492 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 412022014493 Transposase domain (DUF772); Region: DUF772; pfam05598 412022014494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 412022014495 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 412022014496 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 412022014497 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 412022014498 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412022014499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412022014500 TPR motif; other site 412022014501 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 412022014502 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412022014503 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 412022014504 Transglycosylase; Region: Transgly; pfam00912 412022014505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412022014506 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 412022014507 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412022014508 tetramer interface [polypeptide binding]; other site 412022014509 hypothetical protein; Provisional; Region: PRK06815 412022014510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412022014511 catalytic residue [active] 412022014512 acetylornithine deacetylase; Provisional; Region: PRK07522 412022014513 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 412022014514 metal binding site [ion binding]; metal-binding site 412022014515 putative dimer interface [polypeptide binding]; other site 412022014516 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 412022014517 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 412022014518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412022014519 ATP binding site [chemical binding]; other site 412022014520 putative Mg++ binding site [ion binding]; other site 412022014521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412022014522 nucleotide binding region [chemical binding]; other site 412022014523 ATP-binding site [chemical binding]; other site 412022014524 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 412022014525 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 412022014526 substrate binding site; other site 412022014527 dimer interface; other site 412022014528 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 412022014529 homotrimer interaction site [polypeptide binding]; other site 412022014530 zinc binding site [ion binding]; other site 412022014531 CDP-binding sites; other site 412022014532 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 412022014533 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 412022014534 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 412022014535 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 412022014536 dimer interface [polypeptide binding]; other site 412022014537 decamer (pentamer of dimers) interface [polypeptide binding]; other site 412022014538 catalytic triad [active] 412022014539 peroxidatic and resolving cysteines [active] 412022014540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412022014541 HAMP domain; Region: HAMP; pfam00672 412022014542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412022014543 dimer interface [polypeptide binding]; other site 412022014544 phosphorylation site [posttranslational modification] 412022014545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412022014546 ATP binding site [chemical binding]; other site 412022014547 Mg2+ binding site [ion binding]; other site 412022014548 G-X-G motif; other site 412022014549 osmolarity response regulator; Provisional; Region: ompR; PRK09468 412022014550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412022014551 active site 412022014552 phosphorylation site [posttranslational modification] 412022014553 intermolecular recognition site; other site 412022014554 dimerization interface [polypeptide binding]; other site 412022014555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412022014556 DNA binding site [nucleotide binding] 412022014557 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 412022014558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 412022014559 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 412022014560 active site lid residues [active] 412022014561 substrate binding pocket [chemical binding]; other site 412022014562 catalytic residues [active] 412022014563 substrate-Mg2+ binding site; other site 412022014564 aspartate-rich region 1; other site 412022014565 aspartate-rich region 2; other site 412022014566 Transposase; Region: HTH_Tnp_1; pfam01527 412022014567 HTH-like domain; Region: HTH_21; pfam13276 412022014568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022014569 Integrase core domain; Region: rve; pfam00665 412022014570 Integrase core domain; Region: rve_3; pfam13683 412022014571 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 412022014572 PLD-like domain; Region: PLDc_2; pfam13091 412022014573 putative active site [active] 412022014574 catalytic site [active] 412022014575 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 412022014576 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 412022014577 active site 412022014578 Zn binding site [ion binding]; other site 412022014579 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 412022014580 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 412022014581 trimer interface [polypeptide binding]; other site 412022014582 eyelet of channel; other site 412022014583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412022014584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412022014585 dimerization interface [polypeptide binding]; other site 412022014586 DNA binding residues [nucleotide binding] 412022014587 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 412022014588 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 412022014589 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 412022014590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412022014591 MarR family; Region: MarR_2; pfam12802 412022014592 MarR family; Region: MarR_2; cl17246 412022014593 Glycerate kinase family; Region: Gly_kinase; cl00841 412022014594 trigger factor; Provisional; Region: tig; PRK01490 412022014595 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412022014596 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 412022014597 Clp protease; Region: CLP_protease; pfam00574 412022014598 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412022014599 oligomer interface [polypeptide binding]; other site 412022014600 active site residues [active] 412022014601 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 412022014602 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 412022014603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022014604 Walker A motif; other site 412022014605 ATP binding site [chemical binding]; other site 412022014606 Walker B motif; other site 412022014607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412022014608 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 412022014609 Found in ATP-dependent protease La (LON); Region: LON; smart00464 412022014610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412022014611 Walker A motif; other site 412022014612 ATP binding site [chemical binding]; other site 412022014613 Walker B motif; other site 412022014614 arginine finger; other site 412022014615 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412022014616 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 412022014617 30S subunit binding site; other site 412022014618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 412022014619 SurA N-terminal domain; Region: SurA_N_3; cl07813 412022014620 periplasmic folding chaperone; Provisional; Region: PRK10788 412022014621 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412022014622 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 412022014623 active site 412022014624 catalytic triad [active] 412022014625 oxyanion hole [active] 412022014626 switch loop; other site 412022014627 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 412022014628 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412022014629 Walker A/P-loop; other site 412022014630 ATP binding site [chemical binding]; other site 412022014631 Q-loop/lid; other site 412022014632 ABC transporter signature motif; other site 412022014633 Walker B; other site 412022014634 D-loop; other site 412022014635 H-loop/switch region; other site 412022014636 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 412022014637 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 412022014638 active site 412022014639 dimer interface [polypeptide binding]; other site 412022014640 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 412022014641 dimer interface [polypeptide binding]; other site 412022014642 active site 412022014643 similar to hypothetical protein 412022014644 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 412022014645 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 412022014646 putative substrate binding site [chemical binding]; other site 412022014647 putative ATP binding site [chemical binding]; other site 412022014648 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 412022014649 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 412022014650 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 412022014651 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 412022014652 dimerization interface [polypeptide binding]; other site 412022014653 ATP binding site [chemical binding]; other site 412022014654 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 412022014655 dimerization interface [polypeptide binding]; other site 412022014656 ATP binding site [chemical binding]; other site 412022014657 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 412022014658 putative active site [active] 412022014659 catalytic triad [active] 412022014660 Predicted acetyltransferase [General function prediction only]; Region: COG3153 412022014661 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 412022014662 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412022014663 BolA-like protein; Region: BolA; pfam01722 412022014664 intracellular septation protein A; Reviewed; Region: PRK00259 412022014665 SelR domain; Region: SelR; pfam01641 412022014666 methionine sulfoxide reductase B; Provisional; Region: PRK00222 412022014667 Uncharacterized conserved protein [Function unknown]; Region: COG0397 412022014668 hypothetical protein; Validated; Region: PRK00029 412022014669 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 412022014670 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 412022014671 dimer interface [polypeptide binding]; other site 412022014672 acyl-activating enzyme (AAE) consensus motif; other site 412022014673 putative active site [active] 412022014674 AMP binding site [chemical binding]; other site 412022014675 putative CoA binding site [chemical binding]; other site 412022014676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412022014677 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 412022014678 substrate binding site [chemical binding]; other site 412022014679 oxyanion hole (OAH) forming residues; other site 412022014680 trimer interface [polypeptide binding]; other site 412022014681 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412022014682 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022014683 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412022014684 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 412022014685 catalytic triad [active] 412022014686 metal binding site [ion binding]; metal-binding site 412022014687 conserved cis-peptide bond; other site 412022014688 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 412022014689 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412022014690 dimer interface [polypeptide binding]; other site 412022014691 active site 412022014692 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 412022014693 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412022014694 CoenzymeA binding site [chemical binding]; other site 412022014695 subunit interaction site [polypeptide binding]; other site 412022014696 PHB binding site; other site 412022014697 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 412022014698 Prostaglandin dehydrogenases; Region: PGDH; cd05288 412022014699 NAD(P) binding site [chemical binding]; other site 412022014700 substrate binding site [chemical binding]; other site 412022014701 dimer interface [polypeptide binding]; other site 412022014702 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 412022014703 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 412022014704 substrate binding pocket [chemical binding]; other site 412022014705 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412022014706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022014707 Coenzyme A binding pocket [chemical binding]; other site 412022014708 NRDE protein; Region: NRDE; cl01315 412022014709 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 412022014710 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 412022014711 YceG-like family; Region: YceG; pfam02618 412022014712 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 412022014713 dimerization interface [polypeptide binding]; other site 412022014714 thymidylate kinase; Validated; Region: tmk; PRK00698 412022014715 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 412022014716 TMP-binding site; other site 412022014717 ATP-binding site [chemical binding]; other site 412022014718 DNA polymerase III subunit delta'; Validated; Region: PRK06964 412022014719 DNA polymerase III subunit delta'; Validated; Region: PRK08485 412022014720 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 412022014721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412022014722 Coenzyme A binding pocket [chemical binding]; other site 412022014723 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412022014724 active site 412022014725 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412022014726 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412022014727 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412022014728 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 412022014729 Mechanosensitive ion channel; Region: MS_channel; pfam00924 412022014730 Predicted ATPase [General function prediction only]; Region: COG4637 412022014731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412022014732 Walker A/P-loop; other site 412022014733 ATP binding site [chemical binding]; other site 412022014734 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 412022014735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412022014736 putative ADP-binding pocket [chemical binding]; other site 412022014737 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 412022014738 Domain of unknown function DUF221; Region: DUF221; pfam02714 412022014739 psiF repeat; Region: PsiF_repeat; pfam07769 412022014740 psiF repeat; Region: PsiF_repeat; pfam07769 412022014741 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 412022014742 active site 412022014743 homodimer interface [polypeptide binding]; other site 412022014744 homotetramer interface [polypeptide binding]; other site 412022014745 Transposase; Region: HTH_Tnp_1; pfam01527 412022014746 HTH-like domain; Region: HTH_21; pfam13276 412022014747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022014748 Integrase core domain; Region: rve; pfam00665 412022014749 Integrase core domain; Region: rve_3; pfam13683 412022014750 Transposase; Region: HTH_Tnp_1; cl17663 412022014751 HTH-like domain; Region: HTH_21; pfam13276 412022014752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412022014753 Integrase core domain; Region: rve; pfam00665 412022014754 Integrase core domain; Region: rve_3; pfam13683 412022014755 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 412022014756 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412022014757 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412022014758 active site 412022014759 metal binding site [ion binding]; metal-binding site 412022014760 RNA polymerase sigma factor; Provisional; Region: PRK12533 412022014761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412022014762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412022014763 DNA binding residues [nucleotide binding]