-- dump date   	20140619_011725
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
563178000001	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
563178000002	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
563178000003	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
563178000004	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
563178000005	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
563178000006	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
563178000007	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
563178000008	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
563178000009	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
563178000010	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
563178000011	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
563178000012	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
563178000013	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
563178000014	beta subunit interaction interface [polypeptide binding]; other site
563178000015	Walker A motif; other site
563178000016	ATP binding site [chemical binding]; other site
563178000017	Walker B motif; other site
563178000018	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
563178000019	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
563178000020	core domain interface [polypeptide binding]; other site
563178000021	delta subunit interface [polypeptide binding]; other site
563178000022	epsilon subunit interface [polypeptide binding]; other site
563178000023	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
563178000024	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
563178000025	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
563178000026	alpha subunit interaction interface [polypeptide binding]; other site
563178000027	Walker A motif; other site
563178000028	ATP binding site [chemical binding]; other site
563178000029	Walker B motif; other site
563178000030	inhibitor binding site; inhibition site
563178000031	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
563178000032	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
563178000033	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
563178000034	gamma subunit interface [polypeptide binding]; other site
563178000035	epsilon subunit interface [polypeptide binding]; other site
563178000036	LBP interface [polypeptide binding]; other site
563178000037	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
563178000038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563178000039	ATP binding site [chemical binding]; other site
563178000040	Mg2+ binding site [ion binding]; other site
563178000041	G-X-G motif; other site
563178000042	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
563178000043	anchoring element; other site
563178000044	dimer interface [polypeptide binding]; other site
563178000045	ATP binding site [chemical binding]; other site
563178000046	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
563178000047	active site
563178000048	putative metal-binding site [ion binding]; other site
563178000049	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
563178000050	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
563178000051	DNA polymerase III subunit beta; Validated; Region: PRK05643
563178000052	putative DNA binding surface [nucleotide binding]; other site
563178000053	dimer interface [polypeptide binding]; other site
563178000054	beta-clamp/clamp loader binding surface; other site
563178000055	beta-clamp/translesion DNA polymerase binding surface; other site
563178000056	DnaA N-terminal domain; Region: DnaA_N; pfam11638
563178000057	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
563178000058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178000059	Walker A motif; other site
563178000060	ATP binding site [chemical binding]; other site
563178000061	Walker B motif; other site
563178000062	arginine finger; other site
563178000063	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
563178000064	DnaA box-binding interface [nucleotide binding]; other site
563178000065	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
563178000066	membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593
563178000067	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
563178000068	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
563178000069	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
563178000070	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
563178000071	trmE is a tRNA modification GTPase; Region: trmE; cd04164
563178000072	G1 box; other site
563178000073	GTP/Mg2+ binding site [chemical binding]; other site
563178000074	Switch I region; other site
563178000075	G2 box; other site
563178000076	Switch II region; other site
563178000077	G3 box; other site
563178000078	G4 box; other site
563178000079	G5 box; other site
563178000080	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
563178000081	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
563178000082	oligomerisation interface [polypeptide binding]; other site
563178000083	mobile loop; other site
563178000084	roof hairpin; other site
563178000085	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
563178000086	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
563178000087	ring oligomerisation interface [polypeptide binding]; other site
563178000088	ATP/Mg binding site [chemical binding]; other site
563178000089	stacking interactions; other site
563178000090	hinge regions; other site
563178000091	translation elongation factor P; Region: efp; TIGR00038
563178000092	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
563178000093	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
563178000094	RNA binding site [nucleotide binding]; other site
563178000095	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
563178000096	RNA binding site [nucleotide binding]; other site
563178000097	DNA replication protein DnaC; Validated; Region: PRK07952
563178000098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178000099	Walker A motif; other site
563178000100	ATP binding site [chemical binding]; other site
563178000101	Walker B motif; other site
563178000102	primosomal protein DnaI; Provisional; Region: PRK02854
563178000103	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
563178000104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563178000105	S-adenosylmethionine binding site [chemical binding]; other site
563178000106	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
563178000107	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
563178000108	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
563178000109	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
563178000110	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
563178000111	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
563178000112	DNA binding residues [nucleotide binding]
563178000113	glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135
563178000114	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
563178000115	glutaminase active site [active]
563178000116	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
563178000117	dimer interface [polypeptide binding]; other site
563178000118	active site
563178000119	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
563178000120	dimer interface [polypeptide binding]; other site
563178000121	active site
563178000122	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
563178000123	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
563178000124	Substrate binding site; other site
563178000125	Mg++ binding site; other site
563178000126	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
563178000127	active site
563178000128	substrate binding site [chemical binding]; other site
563178000129	CoA binding site [chemical binding]; other site
563178000130	putative hydrolase; Provisional; Region: PRK10976
563178000131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563178000132	active site
563178000133	motif I; other site
563178000134	motif II; other site
563178000135	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
563178000136	motif II; other site
563178000137	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
563178000138	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
563178000139	THF binding site; other site
563178000140	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
563178000141	substrate binding site [chemical binding]; other site
563178000142	THF binding site; other site
563178000143	zinc-binding site [ion binding]; other site
563178000144	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
563178000145	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
563178000146	purine monophosphate binding site [chemical binding]; other site
563178000147	dimer interface [polypeptide binding]; other site
563178000148	putative catalytic residues [active]
563178000149	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
563178000150	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
563178000151	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
563178000152	IHF dimer interface [polypeptide binding]; other site
563178000153	IHF - DNA interface [nucleotide binding]; other site
563178000154	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
563178000155	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
563178000156	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
563178000157	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
563178000158	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
563178000159	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
563178000160	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
563178000161	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
563178000162	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
563178000163	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
563178000164	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
563178000165	DNA binding site [nucleotide binding]
563178000166	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
563178000167	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
563178000168	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
563178000169	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
563178000170	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
563178000171	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
563178000172	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
563178000173	RPB3 interaction site [polypeptide binding]; other site
563178000174	RPB1 interaction site [polypeptide binding]; other site
563178000175	RPB11 interaction site [polypeptide binding]; other site
563178000176	RPB10 interaction site [polypeptide binding]; other site
563178000177	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
563178000178	core dimer interface [polypeptide binding]; other site
563178000179	peripheral dimer interface [polypeptide binding]; other site
563178000180	L10 interface [polypeptide binding]; other site
563178000181	L11 interface [polypeptide binding]; other site
563178000182	putative EF-Tu interaction site [polypeptide binding]; other site
563178000183	putative EF-G interaction site [polypeptide binding]; other site
563178000184	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
563178000185	23S rRNA interface [nucleotide binding]; other site
563178000186	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
563178000187	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
563178000188	mRNA/rRNA interface [nucleotide binding]; other site
563178000189	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
563178000190	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
563178000191	23S rRNA interface [nucleotide binding]; other site
563178000192	L7/L12 interface [polypeptide binding]; other site
563178000193	putative thiostrepton binding site; other site
563178000194	L25 interface [polypeptide binding]; other site
563178000195	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
563178000196	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
563178000197	putative homodimer interface [polypeptide binding]; other site
563178000198	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
563178000199	heterodimer interface [polypeptide binding]; other site
563178000200	homodimer interface [polypeptide binding]; other site
563178000201	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
563178000202	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
563178000203	FAD binding domain; Region: FAD_binding_4; pfam01565
563178000204	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
563178000205	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
563178000206	FAD binding site [chemical binding]; other site
563178000207	acetylornithine deacetylase; Provisional; Region: PRK05111
563178000208	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
563178000209	metal binding site [ion binding]; metal-binding site
563178000210	putative dimer interface [polypeptide binding]; other site
563178000211	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
563178000212	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
563178000213	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
563178000214	nucleotide binding site [chemical binding]; other site
563178000215	substrate binding site [chemical binding]; other site
563178000216	argininosuccinate synthase; Provisional; Region: PRK13820
563178000217	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
563178000218	ANP binding site [chemical binding]; other site
563178000219	Substrate Binding Site II [chemical binding]; other site
563178000220	Substrate Binding Site I [chemical binding]; other site
563178000221	argininosuccinate lyase; Provisional; Region: PRK04833
563178000222	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
563178000223	active sites [active]
563178000224	tetramer interface [polypeptide binding]; other site
563178000225	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
563178000226	active site residue [active]
563178000227	Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952
563178000228	SecA binding site; other site
563178000229	Preprotein binding site; other site
563178000230	serine acetyltransferase; Provisional; Region: cysE; PRK11132
563178000231	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
563178000232	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
563178000233	trimer interface [polypeptide binding]; other site
563178000234	active site
563178000235	substrate binding site [chemical binding]; other site
563178000236	CoA binding site [chemical binding]; other site
563178000237	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
563178000238	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
563178000239	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
563178000240	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
563178000241	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
563178000242	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
563178000243	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
563178000244	DNA binding residues [nucleotide binding]
563178000245	DNA primase; Validated; Region: dnaG; PRK05667
563178000246	CHC2 zinc finger; Region: zf-CHC2; pfam01807
563178000247	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
563178000248	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
563178000249	active site
563178000250	metal binding site [ion binding]; metal-binding site
563178000251	interdomain interaction site; other site
563178000252	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
563178000253	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
563178000254	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
563178000255	UGMP family protein; Validated; Region: PRK09604
563178000256	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
563178000257	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
563178000258	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
563178000259	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
563178000260	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
563178000261	putative ribose interaction site [chemical binding]; other site
563178000262	putative ADP binding site [chemical binding]; other site
563178000263	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298
563178000264	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
563178000265	active site
563178000266	NTP binding site [chemical binding]; other site
563178000267	metal binding triad [ion binding]; metal-binding site
563178000268	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
563178000269	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
563178000270	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
563178000271	HPr interaction site; other site
563178000272	glycerol kinase (GK) interaction site [polypeptide binding]; other site
563178000273	active site
563178000274	phosphorylation site [posttranslational modification]
563178000275	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
563178000276	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
563178000277	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
563178000278	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
563178000279	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
563178000280	dimerization domain swap beta strand [polypeptide binding]; other site
563178000281	regulatory protein interface [polypeptide binding]; other site
563178000282	active site
563178000283	regulatory phosphorylation site [posttranslational modification]; other site
563178000284	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
563178000285	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
563178000286	dimer interface [polypeptide binding]; other site
563178000287	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563178000288	catalytic residue [active]
563178000289	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
563178000290	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
563178000291	nucleotide binding pocket [chemical binding]; other site
563178000292	K-X-D-G motif; other site
563178000293	catalytic site [active]
563178000294	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
563178000295	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
563178000296	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
563178000297	Dimer interface [polypeptide binding]; other site
563178000298	BRCT sequence motif; other site
563178000299	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
563178000300	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
563178000301	HIGH motif; other site
563178000302	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
563178000303	active site
563178000304	KMSKS motif; other site
563178000305	Flagellar hook-basal body protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliE; COG1677
563178000306	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
563178000307	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
563178000308	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
563178000309	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
563178000310	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
563178000311	FliG C-terminal domain; Region: FliG_C; pfam01706
563178000312	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
563178000313	Flagellar assembly protein FliH; Region: FliH; pfam02108
563178000314	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
563178000315	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
563178000316	Walker A motif; other site
563178000317	ATP binding site [chemical binding]; other site
563178000318	Walker B motif; other site
563178000319	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
563178000320	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
563178000321	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
563178000322	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
563178000323	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
563178000324	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
563178000325	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
563178000326	putative bifunctional flagellar biosynthesis protein FliO/FliP; Provisional; Region: PRK12430
563178000327	Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190
563178000328	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
563178000329	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
563178000330	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
563178000331	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
563178000332	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
563178000333	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
563178000334	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
563178000335	dimer interface [polypeptide binding]; other site
563178000336	substrate binding site [chemical binding]; other site
563178000337	metal binding sites [ion binding]; metal-binding site
563178000338	peptidase PmbA; Provisional; Region: PRK11040
563178000339	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
563178000340	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
563178000341	dimer interface [polypeptide binding]; other site
563178000342	active site
563178000343	transaldolase-like protein; Provisional; Region: PTZ00411
563178000344	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
563178000345	active site
563178000346	dimer interface [polypeptide binding]; other site
563178000347	catalytic residue [active]
563178000348	transketolase; Reviewed; Region: PRK12753
563178000349	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
563178000350	TPP-binding site [chemical binding]; other site
563178000351	dimer interface [polypeptide binding]; other site
563178000352	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
563178000353	PYR/PP interface [polypeptide binding]; other site
563178000354	dimer interface [polypeptide binding]; other site
563178000355	TPP binding site [chemical binding]; other site
563178000356	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563178000357	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
563178000358	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
563178000359	metal binding site [ion binding]; metal-binding site
563178000360	dimer interface [polypeptide binding]; other site
563178000361	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
563178000362	dihydrodipicolinate synthase; Region: dapA; TIGR00674
563178000363	dimer interface [polypeptide binding]; other site
563178000364	active site
563178000365	catalytic residue [active]
563178000366	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
563178000367	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
563178000368	Tetramer interface [polypeptide binding]; other site
563178000369	active site
563178000370	FMN-binding site [chemical binding]; other site
563178000371	hypothetical protein; Provisional; Region: PRK04946
563178000372	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
563178000373	Smr domain; Region: Smr; pfam01713
563178000374	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
563178000375	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
563178000376	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
563178000377	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
563178000378	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
563178000379	NAD binding site [chemical binding]; other site
563178000380	dimerization interface [polypeptide binding]; other site
563178000381	product binding site; other site
563178000382	substrate binding site [chemical binding]; other site
563178000383	zinc binding site [ion binding]; other site
563178000384	catalytic residues [active]
563178000385	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
563178000386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
563178000387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563178000388	homodimer interface [polypeptide binding]; other site
563178000389	catalytic residue [active]
563178000390	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
563178000391	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
563178000392	active site
563178000393	motif I; other site
563178000394	motif II; other site
563178000395	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
563178000396	putative active site pocket [active]
563178000397	4-fold oligomerization interface [polypeptide binding]; other site
563178000398	metal binding residues [ion binding]; metal-binding site
563178000399	3-fold/trimer interface [polypeptide binding]; other site
563178000400	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
563178000401	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
563178000402	putative active site [active]
563178000403	oxyanion strand; other site
563178000404	catalytic triad [active]
563178000405	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
563178000406	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
563178000407	catalytic residues [active]
563178000408	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
563178000409	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
563178000410	substrate binding site [chemical binding]; other site
563178000411	glutamase interaction surface [polypeptide binding]; other site
563178000412	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
563178000413	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
563178000414	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
563178000415	metal binding site [ion binding]; metal-binding site
563178000416	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
563178000417	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
563178000418	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
563178000419	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
563178000420	trimer interface [polypeptide binding]; other site
563178000421	active site
563178000422	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
563178000423	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
563178000424	active site
563178000425	HIGH motif; other site
563178000426	KMSKS motif; other site
563178000427	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
563178000428	tRNA binding surface [nucleotide binding]; other site
563178000429	anticodon binding site; other site
563178000430	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
563178000431	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
563178000432	Ligand Binding Site [chemical binding]; other site
563178000433	TilS substrate binding domain; Region: TilS; pfam09179
563178000434	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
563178000435	Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307
563178000436	Lumazine binding domain; Region: Lum_binding; pfam00677
563178000437	Lumazine binding domain; Region: Lum_binding; pfam00677
563178000438	electron transport complex protein RsxA; Provisional; Region: PRK05151
563178000439	ferredoxin; Provisional; Region: PRK08764
563178000440	Putative Fe-S cluster; Region: FeS; pfam04060
563178000441	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
563178000442	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
563178000443	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
563178000444	electron transport complex, RnfABCDGE type, D subunit; Region: rnfD; TIGR01946
563178000445	Predicted NADH:ubiquinone oxidoreductase, subunit RnfG [Energy production and conversion]; Region: RnfG; COG4659
563178000446	electron transport complex RsxE subunit; Provisional; Region: PRK12405
563178000447	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
563178000448	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
563178000449	minor groove reading motif; other site
563178000450	helix-hairpin-helix signature motif; other site
563178000451	substrate binding pocket [chemical binding]; other site
563178000452	active site
563178000453	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
563178000454	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
563178000455	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
563178000456	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
563178000457	active site
563178000458	HIGH motif; other site
563178000459	dimer interface [polypeptide binding]; other site
563178000460	KMSKS motif; other site
563178000461	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
563178000462	putative inner membrane protein; Provisional; Region: PRK10983
563178000463	Domain of unknown function DUF20; Region: UPF0118; pfam01594
563178000464	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
563178000465	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
563178000466	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
563178000467	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
563178000468	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
563178000469	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
563178000470	active site
563178000471	dimer interface [polypeptide binding]; other site
563178000472	motif 1; other site
563178000473	motif 2; other site
563178000474	motif 3; other site
563178000475	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
563178000476	anticodon binding site; other site
563178000477	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
563178000478	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
563178000479	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
563178000480	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
563178000481	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
563178000482	23S rRNA binding site [nucleotide binding]; other site
563178000483	L21 binding site [polypeptide binding]; other site
563178000484	L13 binding site [polypeptide binding]; other site
563178000485	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
563178000486	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
563178000487	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
563178000488	dimer interface [polypeptide binding]; other site
563178000489	motif 1; other site
563178000490	active site
563178000491	motif 2; other site
563178000492	motif 3; other site
563178000493	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
563178000494	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
563178000495	putative tRNA-binding site [nucleotide binding]; other site
563178000496	B3/4 domain; Region: B3_4; pfam03483
563178000497	tRNA synthetase B5 domain; Region: B5; smart00874
563178000498	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
563178000499	dimer interface [polypeptide binding]; other site
563178000500	motif 1; other site
563178000501	motif 3; other site
563178000502	motif 2; other site
563178000503	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
563178000504	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
563178000505	IHF - DNA interface [nucleotide binding]; other site
563178000506	IHF dimer interface [polypeptide binding]; other site
563178000507	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
563178000508	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
563178000509	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
563178000510	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
563178000511	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
563178000512	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
563178000513	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
563178000514	motif 1; other site
563178000515	dimer interface [polypeptide binding]; other site
563178000516	active site
563178000517	motif 2; other site
563178000518	motif 3; other site
563178000519	endonuclease IV; Provisional; Region: PRK01060
563178000520	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
563178000521	AP (apurinic/apyrimidinic) site pocket; other site
563178000522	DNA interaction; other site
563178000523	Metal-binding active site; metal-binding site
563178000524	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
563178000525	5S rRNA interface [nucleotide binding]; other site
563178000526	CTC domain interface [polypeptide binding]; other site
563178000527	L16 interface [polypeptide binding]; other site
563178000528	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
563178000529	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
563178000530	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
563178000531	SurA N-terminal domain; Region: SurA_N; pfam09312
563178000532	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
563178000533	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
563178000534	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
563178000535	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
563178000536	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
563178000537	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
563178000538	active site
563178000539	metal binding site [ion binding]; metal-binding site
563178000540	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
563178000541	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
563178000542	folate binding site [chemical binding]; other site
563178000543	NADP+ binding site [chemical binding]; other site
563178000544	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
563178000545	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
563178000546	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
563178000547	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
563178000548	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
563178000549	ATP-grasp domain; Region: ATP-grasp_4; cl17255
563178000550	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
563178000551	IMP binding site; other site
563178000552	dimer interface [polypeptide binding]; other site
563178000553	interdomain contacts; other site
563178000554	partial ornithine binding site; other site
563178000555	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
563178000556	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
563178000557	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
563178000558	catalytic site [active]
563178000559	subunit interface [polypeptide binding]; other site
563178000560	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
563178000561	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
563178000562	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
563178000563	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
563178000564	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
563178000565	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
563178000566	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
563178000567	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563178000568	active site
563178000569	HIGH motif; other site
563178000570	nucleotide binding site [chemical binding]; other site
563178000571	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
563178000572	active site
563178000573	KMSKS motif; other site
563178000574	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
563178000575	tRNA binding surface [nucleotide binding]; other site
563178000576	anticodon binding site; other site
563178000577	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
563178000578	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
563178000579	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
563178000580	active site
563178000581	Riboflavin kinase; Region: Flavokinase; smart00904
563178000582	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
563178000583	chaperone protein DnaJ; Provisional; Region: PRK10767
563178000584	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
563178000585	HSP70 interaction site [polypeptide binding]; other site
563178000586	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
563178000587	Zn binding sites [ion binding]; other site
563178000588	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
563178000589	dimer interface [polypeptide binding]; other site
563178000590	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
563178000591	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
563178000592	nucleotide binding site [chemical binding]; other site
563178000593	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
563178000594	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
563178000595	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
563178000596	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
563178000597	NADH dehydrogenase subunit D; Validated; Region: PRK06075
563178000598	NADH dehydrogenase subunit E; Validated; Region: PRK07539
563178000599	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
563178000600	putative dimer interface [polypeptide binding]; other site
563178000601	[2Fe-2S] cluster binding site [ion binding]; other site
563178000602	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
563178000603	SLBB domain; Region: SLBB; pfam10531
563178000604	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
563178000605	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
563178000606	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
563178000607	catalytic loop [active]
563178000608	iron binding site [ion binding]; other site
563178000609	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
563178000610	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
563178000611	[4Fe-4S] binding site [ion binding]; other site
563178000612	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
563178000613	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
563178000614	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
563178000615	4Fe-4S binding domain; Region: Fer4; pfam00037
563178000616	4Fe-4S binding domain; Region: Fer4; pfam00037
563178000617	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
563178000618	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
563178000619	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713
563178000620	proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974
563178000621	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
563178000622	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
563178000623	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
563178000624	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
563178000625	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
563178000626	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
563178000627	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
563178000628	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
563178000629	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
563178000630	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563178000631	active site
563178000632	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
563178000633	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
563178000634	peptide chain release factor 1; Validated; Region: prfA; PRK00591
563178000635	This domain is found in peptide chain release factors; Region: PCRF; smart00937
563178000636	RF-1 domain; Region: RF-1; pfam00472
563178000637	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
563178000638	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563178000639	S-adenosylmethionine binding site [chemical binding]; other site
563178000640	hypothetical protein; Provisional; Region: PRK10941
563178000641	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
563178000642	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
563178000643	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
563178000644	homodimer interface [polypeptide binding]; other site
563178000645	NAD binding pocket [chemical binding]; other site
563178000646	ATP binding pocket [chemical binding]; other site
563178000647	Mg binding site [ion binding]; other site
563178000648	active-site loop [active]
563178000649	propionate/acetate kinase; Provisional; Region: PRK12379
563178000650	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
563178000651	phosphate acetyltransferase; Reviewed; Region: PRK05632
563178000652	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
563178000653	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
563178000654	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
563178000655	catalytic loop [active]
563178000656	iron binding site [ion binding]; other site
563178000657	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
563178000658	dimer interface [polypeptide binding]; other site
563178000659	putative radical transfer pathway; other site
563178000660	diiron center [ion binding]; other site
563178000661	tyrosyl radical; other site
563178000662	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
563178000663	ATP cone domain; Region: ATP-cone; pfam03477
563178000664	Class I ribonucleotide reductase; Region: RNR_I; cd01679
563178000665	active site
563178000666	dimer interface [polypeptide binding]; other site
563178000667	catalytic residues [active]
563178000668	effector binding site; other site
563178000669	DNA gyrase subunit A; Validated; Region: PRK05560
563178000670	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
563178000671	CAP-like domain; other site
563178000672	active site
563178000673	primary dimer interface [polypeptide binding]; other site
563178000674	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563178000675	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563178000676	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563178000677	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563178000678	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563178000679	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
563178000680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
563178000681	peroxidase; Provisional; Region: PRK15000
563178000682	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
563178000683	dimer interface [polypeptide binding]; other site
563178000684	decamer (pentamer of dimers) interface [polypeptide binding]; other site
563178000685	catalytic triad [active]
563178000686	peroxidatic and resolving cysteines [active]
563178000687	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
563178000688	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
563178000689	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
563178000690	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
563178000691	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
563178000692	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
563178000693	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
563178000694	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
563178000695	putative GSH binding site [chemical binding]; other site
563178000696	catalytic residues [active]
563178000697	ribonuclease T; Provisional; Region: PRK05168
563178000698	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
563178000699	active site
563178000700	catalytic site [active]
563178000701	substrate binding site [chemical binding]; other site
563178000702	superoxide dismutase; Provisional; Region: PRK10925
563178000703	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
563178000704	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
563178000705	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
563178000706	putative active site [active]
563178000707	catalytic residue [active]
563178000708	GTP-binding protein YchF; Reviewed; Region: PRK09601
563178000709	YchF GTPase; Region: YchF; cd01900
563178000710	G1 box; other site
563178000711	GTP/Mg2+ binding site [chemical binding]; other site
563178000712	Switch I region; other site
563178000713	G2 box; other site
563178000714	Switch II region; other site
563178000715	G3 box; other site
563178000716	G4 box; other site
563178000717	G5 box; other site
563178000718	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
563178000719	threonine synthase; Validated; Region: PRK09225
563178000720	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
563178000721	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563178000722	catalytic residue [active]
563178000723	homoserine kinase; Provisional; Region: PRK01212
563178000724	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
563178000725	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
563178000726	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
563178000727	nucleotide binding site [chemical binding]; other site
563178000728	substrate binding site [chemical binding]; other site
563178000729	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
563178000730	dimer interface [polypeptide binding]; other site
563178000731	putative threonine allosteric regulatory site; other site
563178000732	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
563178000733	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
563178000734	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
563178000735	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563178000736	active site
563178000737	pantoate--beta-alanine ligase; Region: panC; TIGR00018
563178000738	Pantoate-beta-alanine ligase; Region: PanC; cd00560
563178000739	active site
563178000740	ATP-binding site [chemical binding]; other site
563178000741	pantoate-binding site; other site
563178000742	HXXH motif; other site
563178000743	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
563178000744	oligomerization interface [polypeptide binding]; other site
563178000745	active site
563178000746	metal binding site [ion binding]; metal-binding site
563178000747	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
563178000748	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
563178000749	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
563178000750	dimerization interface 3.5A [polypeptide binding]; other site
563178000751	active site
563178000752	penicillin-binding protein 1b; Provisional; Region: PRK14850
563178000753	Transglycosylase; Region: Transgly; pfam00912
563178000754	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
563178000755	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
563178000756	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
563178000757	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
563178000758	nucleotide binding region [chemical binding]; other site
563178000759	ATP-binding site [chemical binding]; other site
563178000760	SEC-C motif; Region: SEC-C; pfam02810
563178000761	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
563178000762	active site
563178000763	8-oxo-dGMP binding site [chemical binding]; other site
563178000764	nudix motif; other site
563178000765	metal binding site [ion binding]; metal-binding site
563178000766	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
563178000767	dephospho-CoA kinase; Region: TIGR00152
563178000768	CoA-binding site [chemical binding]; other site
563178000769	ATP-binding [chemical binding]; other site
563178000770	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
563178000771	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
563178000772	active site
563178000773	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
563178000774	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
563178000775	dimer interface [polypeptide binding]; other site
563178000776	TPP-binding site [chemical binding]; other site
563178000777	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
563178000778	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
563178000779	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
563178000780	E3 interaction surface; other site
563178000781	lipoyl attachment site [posttranslational modification]; other site
563178000782	e3 binding domain; Region: E3_binding; pfam02817
563178000783	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
563178000784	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
563178000785	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563178000786	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563178000787	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
563178000788	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
563178000789	spermidine synthase; Provisional; Region: PRK00811
563178000790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563178000791	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
563178000792	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
563178000793	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
563178000794	cell division protein FtsZ; Validated; Region: PRK09330
563178000795	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
563178000796	nucleotide binding site [chemical binding]; other site
563178000797	SulA interaction site; other site
563178000798	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
563178000799	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
563178000800	nucleotide binding site [chemical binding]; other site
563178000801	Cell division protein FtsA; Region: FtsA; pfam14450
563178000802	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
563178000803	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
563178000804	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563178000805	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563178000806	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
563178000807	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
563178000808	active site
563178000809	homodimer interface [polypeptide binding]; other site
563178000810	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
563178000811	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
563178000812	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563178000813	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563178000814	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
563178000815	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
563178000816	Mg++ binding site [ion binding]; other site
563178000817	putative catalytic motif [active]
563178000818	putative substrate binding site [chemical binding]; other site
563178000819	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
563178000820	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
563178000821	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563178000822	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
563178000823	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
563178000824	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
563178000825	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
563178000826	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
563178000827	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
563178000828	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
563178000829	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
563178000830	MraW methylase family; Region: Methyltransf_5; cl17771
563178000831	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
563178000832	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
563178000833	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
563178000834	putative valine binding site [chemical binding]; other site
563178000835	dimer interface [polypeptide binding]; other site
563178000836	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
563178000837	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
563178000838	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
563178000839	PYR/PP interface [polypeptide binding]; other site
563178000840	dimer interface [polypeptide binding]; other site
563178000841	TPP binding site [chemical binding]; other site
563178000842	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
563178000843	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
563178000844	TPP-binding site [chemical binding]; other site
563178000845	dimer interface [polypeptide binding]; other site
563178000846	serine endoprotease; Provisional; Region: PRK10942
563178000847	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
563178000848	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
563178000849	protein binding site [polypeptide binding]; other site
563178000850	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
563178000851	protein binding site [polypeptide binding]; other site
563178000852	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
563178000853	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
563178000854	trimer interface [polypeptide binding]; other site
563178000855	active site
563178000856	substrate binding site [chemical binding]; other site
563178000857	CoA binding site [chemical binding]; other site
563178000858	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
563178000859	active site
563178000860	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
563178000861	rRNA interaction site [nucleotide binding]; other site
563178000862	S8 interaction site; other site
563178000863	putative laminin-1 binding site; other site
563178000864	elongation factor Ts; Provisional; Region: tsf; PRK09377
563178000865	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
563178000866	Elongation factor TS; Region: EF_TS; pfam00889
563178000867	Elongation factor TS; Region: EF_TS; pfam00889
563178000868	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
563178000869	putative nucleotide binding site [chemical binding]; other site
563178000870	uridine monophosphate binding site [chemical binding]; other site
563178000871	homohexameric interface [polypeptide binding]; other site
563178000872	ribosome recycling factor; Reviewed; Region: frr; PRK00083
563178000873	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
563178000874	hinge region; other site
563178000875	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
563178000876	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
563178000877	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
563178000878	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
563178000879	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
563178000880	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
563178000881	catalytic residue [active]
563178000882	putative FPP diphosphate  binding site; other site
563178000883	putative FPP binding hydrophobic cleft; other site
563178000884	dimer interface [polypeptide binding]; other site
563178000885	putative IPP diphosphate binding site; other site
563178000886	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
563178000887	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
563178000888	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
563178000889	Surface antigen; Region: Bac_surface_Ag; pfam01103
563178000890	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
563178000891	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
563178000892	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
563178000893	putative active site [active]
563178000894	putative PHP Thumb interface [polypeptide binding]; other site
563178000895	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
563178000896	generic binding surface I; other site
563178000897	generic binding surface II; other site
563178000898	prolyl-tRNA synthetase; Provisional; Region: PRK09194
563178000899	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
563178000900	dimer interface [polypeptide binding]; other site
563178000901	motif 1; other site
563178000902	active site
563178000903	motif 2; other site
563178000904	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
563178000905	putative deacylase active site [active]
563178000906	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
563178000907	active site
563178000908	motif 3; other site
563178000909	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
563178000910	anticodon binding site; other site
563178000911	flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328
563178000912	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
563178000913	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
563178000914	FHIPEP family; Region: FHIPEP; pfam00771
563178000915	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
563178000916	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
563178000917	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
563178000918	active site
563178000919	HIGH motif; other site
563178000920	KMSK motif region; other site
563178000921	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
563178000922	tRNA binding surface [nucleotide binding]; other site
563178000923	anticodon binding site; other site
563178000924	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
563178000925	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
563178000926	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
563178000927	active site
563178000928	catalytic site [active]
563178000929	substrate binding site [chemical binding]; other site
563178000930	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
563178000931	dimer interface [polypeptide binding]; other site
563178000932	active site
563178000933	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563178000934	active site
563178000935	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
563178000936	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
563178000937	dimer interface [polypeptide binding]; other site
563178000938	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
563178000939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
563178000940	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
563178000941	SmpB-tmRNA interface; other site
563178000942	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
563178000943	nucleoside/Zn binding site; other site
563178000944	dimer interface [polypeptide binding]; other site
563178000945	catalytic motif [active]
563178000946	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
563178000947	GTPase [General function prediction only]; Region: Era; COG1159
563178000948	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
563178000949	G1 box; other site
563178000950	GTP/Mg2+ binding site [chemical binding]; other site
563178000951	Switch I region; other site
563178000952	G2 box; other site
563178000953	Switch II region; other site
563178000954	G3 box; other site
563178000955	G4 box; other site
563178000956	G5 box; other site
563178000957	ribonuclease III; Reviewed; Region: rnc; PRK00102
563178000958	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
563178000959	dimerization interface [polypeptide binding]; other site
563178000960	active site
563178000961	metal binding site [ion binding]; metal-binding site
563178000962	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
563178000963	dsRNA binding site [nucleotide binding]; other site
563178000964	signal peptidase I; Provisional; Region: PRK10861
563178000965	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563178000966	Catalytic site [active]
563178000967	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
563178000968	GTP-binding protein LepA; Provisional; Region: PRK05433
563178000969	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
563178000970	G1 box; other site
563178000971	putative GEF interaction site [polypeptide binding]; other site
563178000972	GTP/Mg2+ binding site [chemical binding]; other site
563178000973	Switch I region; other site
563178000974	G2 box; other site
563178000975	G3 box; other site
563178000976	Switch II region; other site
563178000977	G4 box; other site
563178000978	G5 box; other site
563178000979	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
563178000980	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
563178000981	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
563178000982	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
563178000983	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
563178000984	Ligand Binding Site [chemical binding]; other site
563178000985	Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915
563178000986	adenylosuccinate lyase; Provisional; Region: PRK09285
563178000987	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
563178000988	tetramer interface [polypeptide binding]; other site
563178000989	active site
563178000990	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
563178000991	N-acetyl-D-glucosamine binding site [chemical binding]; other site
563178000992	catalytic residue [active]
563178000993	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
563178000994	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
563178000995	NAD binding site [chemical binding]; other site
563178000996	homotetramer interface [polypeptide binding]; other site
563178000997	homodimer interface [polypeptide binding]; other site
563178000998	substrate binding site [chemical binding]; other site
563178000999	active site
563178001000	Exoribonuclease II [Transcription]; Region: Rnb; COG4776
563178001001	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
563178001002	RNB domain; Region: RNB; pfam00773
563178001003	hypothetical protein; Provisional; Region: PRK11111
563178001004	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
563178001005	lipoyl synthase; Provisional; Region: PRK05481
563178001006	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
563178001007	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
563178001008	active site
563178001009	dimer interface [polypeptide binding]; other site
563178001010	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
563178001011	dimerization interface [polypeptide binding]; other site
563178001012	active site
563178001013	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
563178001014	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
563178001015	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
563178001016	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
563178001017	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
563178001018	putative active site [active]
563178001019	catalytic site [active]
563178001020	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
563178001021	putative active site [active]
563178001022	catalytic site [active]
563178001023	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
563178001024	Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917
563178001025	Uncharacterized protein family (UPF0259); Region: UPF0259; pfam06790
563178001026	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
563178001027	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
563178001028	substrate binding site [chemical binding]; other site
563178001029	active site
563178001030	catalytic residues [active]
563178001031	heterodimer interface [polypeptide binding]; other site
563178001032	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
563178001033	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
563178001034	active site
563178001035	ribulose/triose binding site [chemical binding]; other site
563178001036	phosphate binding site [ion binding]; other site
563178001037	substrate (anthranilate) binding pocket [chemical binding]; other site
563178001038	product (indole) binding pocket [chemical binding]; other site
563178001039	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
563178001040	active site
563178001041	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
563178001042	anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245
563178001043	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
563178001044	EamA-like transporter family; Region: EamA; pfam00892
563178001045	EamA-like transporter family; Region: EamA; pfam00892
563178001046	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
563178001047	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
563178001048	probable active site [active]
563178001049	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
563178001050	putative inner membrane peptidase; Provisional; Region: PRK11778
563178001051	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
563178001052	tandem repeat interface [polypeptide binding]; other site
563178001053	oligomer interface [polypeptide binding]; other site
563178001054	active site residues [active]
563178001055	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
563178001056	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
563178001057	active site
563178001058	interdomain interaction site; other site
563178001059	putative metal-binding site [ion binding]; other site
563178001060	nucleotide binding site [chemical binding]; other site
563178001061	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
563178001062	domain I; other site
563178001063	DNA binding groove [nucleotide binding]
563178001064	phosphate binding site [ion binding]; other site
563178001065	domain II; other site
563178001066	domain III; other site
563178001067	nucleotide binding site [chemical binding]; other site
563178001068	catalytic site [active]
563178001069	domain IV; other site
563178001070	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
563178001071	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
563178001072	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
563178001073	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
563178001074	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
563178001075	active site
563178001076	dimerization interface [polypeptide binding]; other site
563178001077	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
563178001078	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563178001079	FeS/SAM binding site; other site
563178001080	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
563178001081	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
563178001082	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
563178001083	histidyl-tRNA synthetase; Region: hisS; TIGR00442
563178001084	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
563178001085	dimer interface [polypeptide binding]; other site
563178001086	motif 1; other site
563178001087	active site
563178001088	motif 2; other site
563178001089	motif 3; other site
563178001090	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
563178001091	anticodon binding site; other site
563178001092	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
563178001093	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
563178001094	dimer interface [polypeptide binding]; other site
563178001095	active site
563178001096	glycine-pyridoxal phosphate binding site [chemical binding]; other site
563178001097	folate binding site [chemical binding]; other site
563178001098	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
563178001099	AAA domain; Region: AAA_26; pfam13500
563178001100	biotin synthase; Provisional; Region: PRK15108
563178001101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563178001102	FeS/SAM binding site; other site
563178001103	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
563178001104	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
563178001105	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
563178001106	inhibitor-cofactor binding pocket; inhibition site
563178001107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563178001108	catalytic residue [active]
563178001109	6-phosphogluconolactonase; Provisional; Region: PRK11028
563178001110	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
563178001111	DEAD-like helicases superfamily; Region: DEXDc; smart00487
563178001112	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
563178001113	ATP binding site [chemical binding]; other site
563178001114	putative Mg++ binding site [ion binding]; other site
563178001115	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563178001116	nucleotide binding region [chemical binding]; other site
563178001117	ATP-binding site [chemical binding]; other site
563178001118	TRCF domain; Region: TRCF; pfam03461
563178001119	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
563178001120	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
563178001121	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
563178001122	Walker A/P-loop; other site
563178001123	ATP binding site [chemical binding]; other site
563178001124	Q-loop/lid; other site
563178001125	ABC transporter signature motif; other site
563178001126	Walker B; other site
563178001127	D-loop; other site
563178001128	H-loop/switch region; other site
563178001129	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
563178001130	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
563178001131	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
563178001132	flavodoxin FldA; Validated; Region: PRK09267
563178001133	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
563178001134	DNA photolyase; Region: DNA_photolyase; pfam00875
563178001135	Uncharacterized conserved protein [Function unknown]; Region: COG0327
563178001136	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
563178001137	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
563178001138	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
563178001139	TPP-binding site [chemical binding]; other site
563178001140	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
563178001141	2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
563178001142	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
563178001143	E3 interaction surface; other site
563178001144	lipoyl attachment site [posttranslational modification]; other site
563178001145	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
563178001146	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563178001147	catalytic core [active]
563178001148	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
563178001149	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
563178001150	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
563178001151	active site
563178001152	ADP/pyrophosphate binding site [chemical binding]; other site
563178001153	dimerization interface [polypeptide binding]; other site
563178001154	allosteric effector site; other site
563178001155	fructose-1,6-bisphosphate binding site; other site
563178001156	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
563178001157	amphipathic channel; other site
563178001158	Asn-Pro-Ala signature motifs; other site
563178001159	triosephosphate isomerase; Provisional; Region: PRK14567
563178001160	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
563178001161	substrate binding site [chemical binding]; other site
563178001162	dimer interface [polypeptide binding]; other site
563178001163	catalytic triad [active]
563178001164	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
563178001165	IHF dimer interface [polypeptide binding]; other site
563178001166	IHF - DNA interface [nucleotide binding]; other site
563178001167	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
563178001168	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
563178001169	RNA binding site [nucleotide binding]; other site
563178001170	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
563178001171	RNA binding site [nucleotide binding]; other site
563178001172	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
563178001173	RNA binding site [nucleotide binding]; other site
563178001174	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
563178001175	RNA binding site [nucleotide binding]; other site
563178001176	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
563178001177	RNA binding site [nucleotide binding]; other site
563178001178	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
563178001179	RNA binding site [nucleotide binding]; other site
563178001180	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
563178001181	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
563178001182	hinge; other site
563178001183	active site
563178001184	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
563178001185	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563178001186	catalytic residue [active]
563178001187	seryl-tRNA synthetase; Provisional; Region: PRK05431
563178001188	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
563178001189	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
563178001190	dimer interface [polypeptide binding]; other site
563178001191	active site
563178001192	motif 1; other site
563178001193	motif 2; other site
563178001194	motif 3; other site
563178001195	thioredoxin reductase; Provisional; Region: PRK10262
563178001196	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
563178001197	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
563178001198	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
563178001199	rRNA binding site [nucleotide binding]; other site
563178001200	predicted 30S ribosome binding site; other site
563178001201	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
563178001202	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
563178001203	dimer interface [polypeptide binding]; other site
563178001204	anticodon binding site; other site
563178001205	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
563178001206	homodimer interface [polypeptide binding]; other site
563178001207	motif 1; other site
563178001208	active site
563178001209	motif 2; other site
563178001210	GAD domain; Region: GAD; pfam02938
563178001211	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
563178001212	active site
563178001213	motif 3; other site
563178001214	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
563178001215	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
563178001216	ABC-ATPase subunit  interface; other site
563178001217	dimer interface [polypeptide binding]; other site
563178001218	putative PBP binding regions; other site
563178001219	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
563178001220	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
563178001221	pyruvate kinase; Provisional; Region: PRK05826
563178001222	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
563178001223	domain interfaces; other site
563178001224	active site
563178001225	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
563178001226	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
563178001227	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
563178001228	heat shock protein HtpX; Provisional; Region: PRK05457
563178001229	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
563178001230	DNA-binding site [nucleotide binding]; DNA binding site
563178001231	RNA-binding motif; other site
563178001232	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
563178001233	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
563178001234	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
563178001235	Transporter associated domain; Region: CorC_HlyC; smart01091
563178001236	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
563178001237	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
563178001238	cell division inhibitor MinD; Provisional; Region: PRK10818
563178001239	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
563178001240	Switch I; other site
563178001241	Switch II; other site
563178001242	septum formation inhibitor; Reviewed; Region: minC; PRK03511
563178001243	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
563178001244	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
563178001245	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
563178001246	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
563178001247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563178001248	S-adenosylmethionine binding site [chemical binding]; other site
563178001249	outer membrane protein A; Reviewed; Region: PRK10808
563178001250	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
563178001251	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
563178001252	ligand binding site [chemical binding]; other site
563178001253	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
563178001254	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
563178001255	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
563178001256	active site
563178001257	substrate binding pocket [chemical binding]; other site
563178001258	dimer interface [polypeptide binding]; other site
563178001259	FlgN protein; Region: FlgN; cl09176
563178001260	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
563178001261	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
563178001262	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
563178001263	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
563178001264	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563178001265	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
563178001266	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
563178001267	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
563178001268	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
563178001269	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
563178001270	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563178001271	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
563178001272	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
563178001273	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563178001274	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
563178001275	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
563178001276	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
563178001277	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
563178001278	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
563178001279	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
563178001280	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
563178001281	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
563178001282	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
563178001283	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
563178001284	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
563178001285	homodimer interface [polypeptide binding]; other site
563178001286	oligonucleotide binding site [chemical binding]; other site
563178001287	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
563178001288	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563178001289	RNA binding surface [nucleotide binding]; other site
563178001290	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
563178001291	active site
563178001292	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
563178001293	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
563178001294	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
563178001295	NAD(P) binding site [chemical binding]; other site
563178001296	homotetramer interface [polypeptide binding]; other site
563178001297	homodimer interface [polypeptide binding]; other site
563178001298	active site
563178001299	acyl carrier protein; Provisional; Region: acpP; PRK00982
563178001300	thymidylate kinase; Validated; Region: tmk; PRK00698
563178001301	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
563178001302	TMP-binding site; other site
563178001303	ATP-binding site [chemical binding]; other site
563178001304	DNA polymerase III subunit delta'; Validated; Region: PRK07993
563178001305	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
563178001306	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
563178001307	active site
563178001308	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
563178001309	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
563178001310	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
563178001311	active site turn [active]
563178001312	phosphorylation site [posttranslational modification]
563178001313	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
563178001314	nucleotide binding site/active site [active]
563178001315	HIT family signature motif; other site
563178001316	catalytic residue [active]
563178001317	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
563178001318	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
563178001319	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
563178001320	trimer interface [polypeptide binding]; other site
563178001321	eyelet of channel; other site
563178001322	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
563178001323	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
563178001324	putative dimer interface [polypeptide binding]; other site
563178001325	putative anticodon binding site; other site
563178001326	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
563178001327	homodimer interface [polypeptide binding]; other site
563178001328	motif 1; other site
563178001329	motif 2; other site
563178001330	active site
563178001331	motif 3; other site
563178001332	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
563178001333	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
563178001334	active site
563178001335	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
563178001336	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
563178001337	active site
563178001338	catalytic residues [active]
563178001339	FMN binding site [chemical binding]; other site
563178001340	quinone interaction residues [chemical binding]; other site
563178001341	substrate binding site [chemical binding]; other site
563178001342	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
563178001343	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
563178001344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
563178001345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563178001346	S-adenosylmethionine binding site [chemical binding]; other site
563178001347	ABC transporter ATPase component; Reviewed; Region: PRK11147
563178001348	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563178001349	ABC transporter; Region: ABC_tran_2; pfam12848
563178001350	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
563178001351	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
563178001352	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
563178001353	active site residue [active]
563178001354	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
563178001355	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563178001356	active site
563178001357	HIGH motif; other site
563178001358	nucleotide binding site [chemical binding]; other site
563178001359	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
563178001360	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
563178001361	active site
563178001362	KMSKS motif; other site
563178001363	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
563178001364	tRNA binding surface [nucleotide binding]; other site
563178001365	anticodon binding site; other site
563178001366	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
563178001367	multifunctional aminopeptidase A; Provisional; Region: PRK00913
563178001368	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
563178001369	interface (dimer of trimers) [polypeptide binding]; other site
563178001370	Substrate-binding/catalytic site; other site
563178001371	Zn-binding sites [ion binding]; other site
563178001372	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
563178001373	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
563178001374	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
563178001375	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
563178001376	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
563178001377	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
563178001378	Aspartate carbamoyltransferase, regulatory subunit [Nucleotide transport and metabolism]; Region: PyrI; COG1781
563178001379	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
563178001380	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
563178001381	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
563178001382	homotrimer interaction site [polypeptide binding]; other site
563178001383	putative active site [active]
563178001384	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
563178001385	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
563178001386	ATP binding site [chemical binding]; other site
563178001387	Mg++ binding site [ion binding]; other site
563178001388	motif III; other site
563178001389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
563178001390	nucleotide binding region [chemical binding]; other site
563178001391	ATP-binding site [chemical binding]; other site
563178001392	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
563178001393	putative RNA binding site [nucleotide binding]; other site
563178001394	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
563178001395	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
563178001396	RNase E interface [polypeptide binding]; other site
563178001397	trimer interface [polypeptide binding]; other site
563178001398	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
563178001399	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
563178001400	RNase E interface [polypeptide binding]; other site
563178001401	trimer interface [polypeptide binding]; other site
563178001402	active site
563178001403	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
563178001404	putative nucleic acid binding region [nucleotide binding]; other site
563178001405	G-X-X-G motif; other site
563178001406	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
563178001407	RNA binding site [nucleotide binding]; other site
563178001408	domain interface; other site
563178001409	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
563178001410	16S/18S rRNA binding site [nucleotide binding]; other site
563178001411	S13e-L30e interaction site [polypeptide binding]; other site
563178001412	25S rRNA binding site [nucleotide binding]; other site
563178001413	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
563178001414	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
563178001415	RNA binding site [nucleotide binding]; other site
563178001416	active site
563178001417	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
563178001418	Ribosome-binding factor A; Region: RBFA; pfam02033
563178001419	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
563178001420	translation initiation factor IF-2; Validated; Region: infB; PRK05306
563178001421	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
563178001422	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
563178001423	G1 box; other site
563178001424	putative GEF interaction site [polypeptide binding]; other site
563178001425	GTP/Mg2+ binding site [chemical binding]; other site
563178001426	Switch I region; other site
563178001427	G2 box; other site
563178001428	G3 box; other site
563178001429	Switch II region; other site
563178001430	G4 box; other site
563178001431	G5 box; other site
563178001432	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
563178001433	Translation-initiation factor 2; Region: IF-2; pfam11987
563178001434	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
563178001435	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
563178001436	NusA N-terminal domain; Region: NusA_N; pfam08529
563178001437	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
563178001438	RNA binding site [nucleotide binding]; other site
563178001439	homodimer interface [polypeptide binding]; other site
563178001440	NusA-like KH domain; Region: KH_5; pfam13184
563178001441	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
563178001442	G-X-X-G motif; other site
563178001443	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
563178001444	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
563178001445	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
563178001446	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
563178001447	active site
563178001448	substrate binding site [chemical binding]; other site
563178001449	metal binding site [ion binding]; metal-binding site
563178001450	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
563178001451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178001452	Walker A motif; other site
563178001453	ATP binding site [chemical binding]; other site
563178001454	Walker B motif; other site
563178001455	arginine finger; other site
563178001456	Peptidase family M41; Region: Peptidase_M41; pfam01434
563178001457	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
563178001458	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
563178001459	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
563178001460	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
563178001461	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
563178001462	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
563178001463	hinge; other site
563178001464	active site
563178001465	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
563178001466	Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261
563178001467	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
563178001468	Predicted GTPase [General function prediction only]; Region: Obg; COG0536
563178001469	GTP1/OBG; Region: GTP1_OBG; pfam01018
563178001470	Obg GTPase; Region: Obg; cd01898
563178001471	G1 box; other site
563178001472	GTP/Mg2+ binding site [chemical binding]; other site
563178001473	Switch I region; other site
563178001474	G2 box; other site
563178001475	G3 box; other site
563178001476	Switch II region; other site
563178001477	G4 box; other site
563178001478	G5 box; other site
563178001479	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
563178001480	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
563178001481	23S rRNA interface [nucleotide binding]; other site
563178001482	L3 interface [polypeptide binding]; other site
563178001483	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
563178001484	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
563178001485	Prephenate dehydratase; Region: PDT; pfam00800
563178001486	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
563178001487	putative L-Phe binding site [chemical binding]; other site
563178001488	signal recognition particle protein; Provisional; Region: PRK10867
563178001489	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
563178001490	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
563178001491	P loop; other site
563178001492	GTP binding site [chemical binding]; other site
563178001493	Signal peptide binding domain; Region: SRP_SPB; pfam02978
563178001494	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
563178001495	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
563178001496	RimM N-terminal domain; Region: RimM; pfam01782
563178001497	PRC-barrel domain; Region: PRC; pfam05239
563178001498	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
563178001499	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
563178001500	protease TldD; Provisional; Region: tldD; PRK10735
563178001501	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
563178001502	Dehydroquinase class II; Region: DHquinase_II; pfam01220
563178001503	active site
563178001504	trimer interface [polypeptide binding]; other site
563178001505	dimer interface [polypeptide binding]; other site
563178001506	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
563178001507	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
563178001508	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
563178001509	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563178001510	RNA binding surface [nucleotide binding]; other site
563178001511	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
563178001512	active site
563178001513	Outer membrane lipoprotein; Region: YfiO; pfam13525
563178001514	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
563178001515	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
563178001516	motif 1; other site
563178001517	active site
563178001518	motif 2; other site
563178001519	motif 3; other site
563178001520	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
563178001521	carbon storage regulator; Provisional; Region: PRK01712
563178001522	glutamate--cysteine ligase; Region: glu_cys_ligase; TIGR01434
563178001523	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
563178001524	S-adenosylmethionine synthetase; Validated; Region: PRK05250
563178001525	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
563178001526	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
563178001527	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
563178001528	RNA methyltransferase, RsmE family; Region: TIGR00046
563178001529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
563178001530	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
563178001531	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563178001532	active site
563178001533	dimer interface [polypeptide binding]; other site
563178001534	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
563178001535	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563178001536	active site
563178001537	HIGH motif; other site
563178001538	nucleotide binding site [chemical binding]; other site
563178001539	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563178001540	active site
563178001541	KMSKS motif; other site
563178001542	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
563178001543	CTP synthetase; Validated; Region: pyrG; PRK05380
563178001544	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
563178001545	Catalytic site [active]
563178001546	active site
563178001547	UTP binding site [chemical binding]; other site
563178001548	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
563178001549	active site
563178001550	putative oxyanion hole; other site
563178001551	catalytic triad [active]
563178001552	enolase; Provisional; Region: eno; PRK00077
563178001553	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
563178001554	dimer interface [polypeptide binding]; other site
563178001555	metal binding site [ion binding]; metal-binding site
563178001556	substrate binding pocket [chemical binding]; other site
563178001557	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
563178001558	Peptidase family M23; Region: Peptidase_M23; pfam01551
563178001559	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
563178001560	homotrimer interaction site [polypeptide binding]; other site
563178001561	zinc binding site [ion binding]; other site
563178001562	CDP-binding sites; other site
563178001563	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
563178001564	substrate binding site; other site
563178001565	dimer interface; other site
563178001566	Septum formation initiator; Region: DivIC; cl17659
563178001567	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
563178001568	ligand-binding site [chemical binding]; other site
563178001569	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
563178001570	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
563178001571	G1 box; other site
563178001572	putative GEF interaction site [polypeptide binding]; other site
563178001573	GTP/Mg2+ binding site [chemical binding]; other site
563178001574	Switch I region; other site
563178001575	G2 box; other site
563178001576	CysD dimerization site [polypeptide binding]; other site
563178001577	G3 box; other site
563178001578	Switch II region; other site
563178001579	G4 box; other site
563178001580	G5 box; other site
563178001581	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
563178001582	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
563178001583	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
563178001584	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
563178001585	Active Sites [active]
563178001586	siroheme synthase; Provisional; Region: cysG; PRK10637
563178001587	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
563178001588	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
563178001589	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
563178001590	active site
563178001591	SAM binding site [chemical binding]; other site
563178001592	homodimer interface [polypeptide binding]; other site
563178001593	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
563178001594	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
563178001595	Active Sites [active]
563178001596	sulfite reductase (NADPH) hemoprotein, beta-component; Region: CysI; TIGR02041
563178001597	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
563178001598	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
563178001599	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
563178001600	Flavodoxin; Region: Flavodoxin_1; pfam00258
563178001601	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
563178001602	FAD binding pocket [chemical binding]; other site
563178001603	FAD binding motif [chemical binding]; other site
563178001604	catalytic residues [active]
563178001605	NAD binding pocket [chemical binding]; other site
563178001606	phosphate binding motif [ion binding]; other site
563178001607	beta-alpha-beta structure motif; other site
563178001608	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
563178001609	MutS domain I; Region: MutS_I; pfam01624
563178001610	MutS domain II; Region: MutS_II; pfam05188
563178001611	MutS domain III; Region: MutS_III; pfam05192
563178001612	MutS domain V; Region: MutS_V; pfam00488
563178001613	Walker A/P-loop; other site
563178001614	ATP binding site [chemical binding]; other site
563178001615	Q-loop/lid; other site
563178001616	ABC transporter signature motif; other site
563178001617	Walker B; other site
563178001618	D-loop; other site
563178001619	H-loop/switch region; other site
563178001620	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
563178001621	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
563178001622	catalytic residues [active]
563178001623	hinge region; other site
563178001624	alpha helical domain; other site
563178001625	5'-3' exonuclease; Provisional; Region: PRK14976
563178001626	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
563178001627	active site
563178001628	metal binding site 1 [ion binding]; metal-binding site
563178001629	putative 5' ssDNA interaction site; other site
563178001630	metal binding site 3; metal-binding site
563178001631	metal binding site 2 [ion binding]; metal-binding site
563178001632	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
563178001633	putative DNA binding site [nucleotide binding]; other site
563178001634	putative metal binding site [ion binding]; other site
563178001635	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
563178001636	G1 box; other site
563178001637	GTP/Mg2+ binding site [chemical binding]; other site
563178001638	Switch I region; other site
563178001639	G2 box; other site
563178001640	G3 box; other site
563178001641	Switch II region; other site
563178001642	G4 box; other site
563178001643	G5 box; other site
563178001644	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
563178001645	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
563178001646	G1 box; other site
563178001647	putative GEF interaction site [polypeptide binding]; other site
563178001648	GTP/Mg2+ binding site [chemical binding]; other site
563178001649	Switch I region; other site
563178001650	G2 box; other site
563178001651	G3 box; other site
563178001652	Switch II region; other site
563178001653	G4 box; other site
563178001654	G5 box; other site
563178001655	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
563178001656	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
563178001657	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
563178001658	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
563178001659	catalytic site [active]
563178001660	G-X2-G-X-G-K; other site
563178001661	putative global regulator; Reviewed; Region: PRK09559
563178001662	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
563178001663	peptide chain release factor 2; Validated; Region: prfB; PRK00578
563178001664	This domain is found in peptide chain release factors; Region: PCRF; smart00937
563178001665	RF-1 domain; Region: RF-1; pfam00472
563178001666	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
563178001667	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
563178001668	dimer interface [polypeptide binding]; other site
563178001669	putative anticodon binding site; other site
563178001670	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
563178001671	motif 1; other site
563178001672	active site
563178001673	motif 2; other site
563178001674	motif 3; other site
563178001675	diaminopimelate decarboxylase; Provisional; Region: PRK11165
563178001676	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
563178001677	active site
563178001678	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
563178001679	substrate binding site [chemical binding]; other site
563178001680	catalytic residues [active]
563178001681	dimer interface [polypeptide binding]; other site
563178001682	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
563178001683	thymidylate synthase; Reviewed; Region: thyA; PRK01827
563178001684	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
563178001685	dimerization interface [polypeptide binding]; other site
563178001686	active site
563178001687	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
563178001688	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
563178001689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
563178001690	FeS/SAM binding site; other site
563178001691	TRAM domain; Region: TRAM; pfam01938
563178001692	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
563178001693	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
563178001694	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
563178001695	Transporter associated domain; Region: CorC_HlyC; smart01091
563178001696	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
563178001697	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
563178001698	HIGH motif; other site
563178001699	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
563178001700	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563178001701	active site
563178001702	KMSKS motif; other site
563178001703	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
563178001704	tRNA binding surface [nucleotide binding]; other site
563178001705	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
563178001706	DNA polymerase III, delta subunit; Region: holA; TIGR01128
563178001707	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
563178001708	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
563178001709	active site
563178001710	(T/H)XGH motif; other site
563178001711	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
563178001712	CPxP  motif; other site
563178001713	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
563178001714	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
563178001715	putative antibiotic transporter; Provisional; Region: PRK10739
563178001716	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
563178001717	Phosphoglycerate kinase; Region: PGK; pfam00162
563178001718	substrate binding site [chemical binding]; other site
563178001719	hinge regions; other site
563178001720	ADP binding site [chemical binding]; other site
563178001721	catalytic site [active]
563178001722	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
563178001723	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
563178001724	active site
563178001725	intersubunit interface [polypeptide binding]; other site
563178001726	zinc binding site [ion binding]; other site
563178001727	Na+ binding site [ion binding]; other site
563178001728	mechanosensitive channel MscS; Provisional; Region: PRK10334
563178001729	Conserved TM helix; Region: TM_helix; pfam05552
563178001730	Mechanosensitive ion channel; Region: MS_channel; pfam00924
563178001731	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
563178001732	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
563178001733	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
563178001734	Family description; Region: UvrD_C_2; pfam13538
563178001735	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
563178001736	AAA domain; Region: AAA_30; pfam13604
563178001737	Family description; Region: UvrD_C_2; pfam13538
563178001738	N-acetylglutamate synthase; Validated; Region: PRK05279
563178001739	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
563178001740	putative feedback inhibition sensing region; other site
563178001741	putative nucleotide binding site [chemical binding]; other site
563178001742	putative substrate binding site [chemical binding]; other site
563178001743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
563178001744	Coenzyme A binding pocket [chemical binding]; other site
563178001745	murein transglycosylase A; Provisional; Region: mltA; PRK11162
563178001746	MltA specific insert domain; Region: MltA; pfam03562
563178001747	3D domain; Region: 3D; pfam06725
563178001748	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
563178001749	homopentamer interface [polypeptide binding]; other site
563178001750	active site
563178001751	thiamine-monophosphate kinase; Region: thiL; TIGR01379
563178001752	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
563178001753	ATP binding site [chemical binding]; other site
563178001754	dimerization interface [polypeptide binding]; other site
563178001755	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
563178001756	catalytic motif [active]
563178001757	Zn binding site [ion binding]; other site
563178001758	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
563178001759	RibD C-terminal domain; Region: RibD_C; cl17279
563178001760	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
563178001761	putative RNA binding site [nucleotide binding]; other site
563178001762	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
563178001763	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
563178001764	TPP-binding site; other site
563178001765	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
563178001766	PYR/PP interface [polypeptide binding]; other site
563178001767	dimer interface [polypeptide binding]; other site
563178001768	TPP binding site [chemical binding]; other site
563178001769	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
563178001770	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
563178001771	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
563178001772	substrate binding pocket [chemical binding]; other site
563178001773	chain length determination region; other site
563178001774	substrate-Mg2+ binding site; other site
563178001775	catalytic residues [active]
563178001776	aspartate-rich region 1; other site
563178001777	active site lid residues [active]
563178001778	aspartate-rich region 2; other site
563178001779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563178001780	Major Facilitator Superfamily; Region: MFS_1; pfam07690
563178001781	putative substrate translocation pore; other site
563178001782	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
563178001783	DsrC like protein; Region: DsrC; pfam04358
563178001784	protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473
563178001785	UbiA prenyltransferase family; Region: UbiA; pfam01040
563178001786	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
563178001787	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
563178001788	Subunit I/III interface [polypeptide binding]; other site
563178001789	Subunit III/IV interface [polypeptide binding]; other site
563178001790	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
563178001791	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
563178001792	D-pathway; other site
563178001793	Putative ubiquinol binding site [chemical binding]; other site
563178001794	Low-spin heme (heme b) binding site [chemical binding]; other site
563178001795	Putative water exit pathway; other site
563178001796	Binuclear center (heme o3/CuB) [ion binding]; other site
563178001797	K-pathway; other site
563178001798	Putative proton exit pathway; other site
563178001799	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
563178001800	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
563178001801	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
563178001802	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
563178001803	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544
563178001804	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
563178001805	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
563178001806	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
563178001807	oligomer interface [polypeptide binding]; other site
563178001808	active site residues [active]
563178001809	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
563178001810	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
563178001811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178001812	Walker A motif; other site
563178001813	ATP binding site [chemical binding]; other site
563178001814	Walker B motif; other site
563178001815	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
563178001816	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
563178001817	Found in ATP-dependent protease La (LON); Region: LON; smart00464
563178001818	Found in ATP-dependent protease La (LON); Region: LON; smart00464
563178001819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178001820	Walker A motif; other site
563178001821	ATP binding site [chemical binding]; other site
563178001822	Walker B motif; other site
563178001823	arginine finger; other site
563178001824	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
563178001825	SurA N-terminal domain; Region: SurA_N_3; cl07813
563178001826	periplasmic folding chaperone; Provisional; Region: PRK10788
563178001827	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
563178001828	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
563178001829	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563178001830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563178001831	Walker A/P-loop; other site
563178001832	ATP binding site [chemical binding]; other site
563178001833	Q-loop/lid; other site
563178001834	ABC transporter signature motif; other site
563178001835	Walker B; other site
563178001836	D-loop; other site
563178001837	H-loop/switch region; other site
563178001838	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
563178001839	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
563178001840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
563178001841	Walker A/P-loop; other site
563178001842	ATP binding site [chemical binding]; other site
563178001843	Q-loop/lid; other site
563178001844	ABC transporter signature motif; other site
563178001845	Walker B; other site
563178001846	D-loop; other site
563178001847	H-loop/switch region; other site
563178001848	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961
563178001849	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178001850	Walker A motif; other site
563178001851	ATP binding site [chemical binding]; other site
563178001852	Walker B motif; other site
563178001853	arginine finger; other site
563178001854	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
563178001855	hypothetical protein; Validated; Region: PRK00153
563178001856	heat shock protein 90; Provisional; Region: PRK05218
563178001857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563178001858	ATP binding site [chemical binding]; other site
563178001859	Mg2+ binding site [ion binding]; other site
563178001860	G-X-G motif; other site
563178001861	adenylate kinase; Reviewed; Region: adk; PRK00279
563178001862	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
563178001863	AMP-binding site [chemical binding]; other site
563178001864	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
563178001865	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
563178001866	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
563178001867	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
563178001868	homodimer interface [polypeptide binding]; other site
563178001869	NADP binding site [chemical binding]; other site
563178001870	substrate binding site [chemical binding]; other site
563178001871	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
563178001872	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
563178001873	active site
563178001874	HIGH motif; other site
563178001875	nucleotide binding site [chemical binding]; other site
563178001876	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
563178001877	KMSKS motif; other site
563178001878	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
563178001879	tRNA binding surface [nucleotide binding]; other site
563178001880	anticodon binding site; other site
563178001881	hypothetical protein; Provisional; Region: PRK04998
563178001882	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
563178001883	DNA-binding site [nucleotide binding]; DNA binding site
563178001884	RNA-binding motif; other site
563178001885	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
563178001886	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
563178001887	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
563178001888	shikimate binding site; other site
563178001889	NAD(P) binding site [chemical binding]; other site
563178001890	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
563178001891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Smg; COG2922
563178001892	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
563178001893	active site
563178001894	catalytic residues [active]
563178001895	metal binding site [ion binding]; metal-binding site
563178001896	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
563178001897	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
563178001898	putative active site [active]
563178001899	substrate binding site [chemical binding]; other site
563178001900	putative cosubstrate binding site; other site
563178001901	catalytic site [active]
563178001902	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
563178001903	substrate binding site [chemical binding]; other site
563178001904	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
563178001905	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
563178001906	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
563178001907	alphaNTD homodimer interface [polypeptide binding]; other site
563178001908	alphaNTD - beta interaction site [polypeptide binding]; other site
563178001909	alphaNTD - beta' interaction site [polypeptide binding]; other site
563178001910	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
563178001911	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
563178001912	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
563178001913	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
563178001914	RNA binding surface [nucleotide binding]; other site
563178001915	30S ribosomal protein S11; Validated; Region: PRK05309
563178001916	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
563178001917	30S ribosomal protein S13; Region: bact_S13; TIGR03631
563178001918	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
563178001919	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
563178001920	SecY translocase; Region: SecY; pfam00344
563178001921	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
563178001922	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
563178001923	23S rRNA binding site [nucleotide binding]; other site
563178001924	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
563178001925	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
563178001926	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
563178001927	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
563178001928	5S rRNA interface [nucleotide binding]; other site
563178001929	23S rRNA interface [nucleotide binding]; other site
563178001930	L5 interface [polypeptide binding]; other site
563178001931	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
563178001932	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
563178001933	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
563178001934	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
563178001935	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
563178001936	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
563178001937	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
563178001938	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
563178001939	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
563178001940	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
563178001941	RNA binding site [nucleotide binding]; other site
563178001942	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
563178001943	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
563178001944	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
563178001945	23S rRNA interface [nucleotide binding]; other site
563178001946	putative translocon interaction site; other site
563178001947	signal recognition particle (SRP54) interaction site; other site
563178001948	L23 interface [polypeptide binding]; other site
563178001949	trigger factor interaction site; other site
563178001950	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
563178001951	23S rRNA interface [nucleotide binding]; other site
563178001952	5S rRNA interface [nucleotide binding]; other site
563178001953	putative antibiotic binding site [chemical binding]; other site
563178001954	L25 interface [polypeptide binding]; other site
563178001955	L27 interface [polypeptide binding]; other site
563178001956	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
563178001957	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
563178001958	G-X-X-G motif; other site
563178001959	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
563178001960	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
563178001961	protein-rRNA interface [nucleotide binding]; other site
563178001962	putative translocon binding site; other site
563178001963	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
563178001964	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
563178001965	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
563178001966	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
563178001967	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
563178001968	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
563178001969	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
563178001970	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
563178001971	elongation factor Tu; Reviewed; Region: PRK00049
563178001972	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
563178001973	G1 box; other site
563178001974	GEF interaction site [polypeptide binding]; other site
563178001975	GTP/Mg2+ binding site [chemical binding]; other site
563178001976	Switch I region; other site
563178001977	G2 box; other site
563178001978	G3 box; other site
563178001979	Switch II region; other site
563178001980	G4 box; other site
563178001981	G5 box; other site
563178001982	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
563178001983	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
563178001984	Antibiotic Binding Site [chemical binding]; other site
563178001985	elongation factor G; Reviewed; Region: PRK00007
563178001986	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
563178001987	G1 box; other site
563178001988	putative GEF interaction site [polypeptide binding]; other site
563178001989	GTP/Mg2+ binding site [chemical binding]; other site
563178001990	Switch I region; other site
563178001991	G2 box; other site
563178001992	G3 box; other site
563178001993	Switch II region; other site
563178001994	G4 box; other site
563178001995	G5 box; other site
563178001996	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
563178001997	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
563178001998	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
563178001999	30S ribosomal protein S7; Validated; Region: PRK05302
563178002000	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
563178002001	S17 interaction site [polypeptide binding]; other site
563178002002	S8 interaction site; other site
563178002003	16S rRNA interaction site [nucleotide binding]; other site
563178002004	streptomycin interaction site [chemical binding]; other site
563178002005	23S rRNA interaction site [nucleotide binding]; other site
563178002006	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
563178002007	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
563178002008	sulfur relay protein TusC; Validated; Region: PRK00211
563178002009	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
563178002010	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
563178002011	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
563178002012	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
563178002013	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
563178002014	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
563178002015	inhibitor-cofactor binding pocket; inhibition site
563178002016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
563178002017	catalytic residue [active]
563178002018	putative transporter; Provisional; Region: PRK03699
563178002019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
563178002020	putative substrate translocation pore; other site
563178002021	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
563178002022	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
563178002023	active site
563178002024	HIGH motif; other site
563178002025	dimer interface [polypeptide binding]; other site
563178002026	KMSKS motif; other site
563178002027	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
563178002028	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
563178002029	substrate binding site [chemical binding]; other site
563178002030	hexamer interface [polypeptide binding]; other site
563178002031	metal binding site [ion binding]; metal-binding site
563178002032	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
563178002033	active site
563178002034	dimer interface [polypeptide binding]; other site
563178002035	metal binding site [ion binding]; metal-binding site
563178002036	shikimate kinase; Reviewed; Region: aroK; PRK00131
563178002037	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
563178002038	ADP binding site [chemical binding]; other site
563178002039	magnesium binding site [ion binding]; other site
563178002040	putative shikimate binding site; other site
563178002041	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
563178002042	phosphopentomutase; Provisional; Region: PRK05362
563178002043	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
563178002044	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
563178002045	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
563178002046	G1 box; other site
563178002047	putative GEF interaction site [polypeptide binding]; other site
563178002048	GTP/Mg2+ binding site [chemical binding]; other site
563178002049	Switch I region; other site
563178002050	G2 box; other site
563178002051	G3 box; other site
563178002052	Switch II region; other site
563178002053	G4 box; other site
563178002054	G5 box; other site
563178002055	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
563178002056	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
563178002057	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
563178002058	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
563178002059	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
563178002060	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
563178002061	dimer interface [polypeptide binding]; other site
563178002062	ssDNA binding site [nucleotide binding]; other site
563178002063	tetramer (dimer of dimers) interface [polypeptide binding]; other site
563178002064	replicative DNA helicase; Provisional; Region: PRK08006
563178002065	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
563178002066	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
563178002067	Walker A motif; other site
563178002068	ATP binding site [chemical binding]; other site
563178002069	Walker B motif; other site
563178002070	DNA binding loops [nucleotide binding]
563178002071	glutathione synthetase; Provisional; Region: PRK05246
563178002072	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
563178002073	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
563178002074	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
563178002075	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
563178002076	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
563178002077	catalytic residue [active]
563178002078	HemN family oxidoreductase; Provisional; Region: PRK05660
563178002079	HemN C-terminal domain; Region: HemN_C; pfam06969
563178002080	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
563178002081	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
563178002082	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
563178002083	minor groove reading motif; other site
563178002084	helix-hairpin-helix signature motif; other site
563178002085	substrate binding pocket [chemical binding]; other site
563178002086	active site
563178002087	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
563178002088	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
563178002089	DNA binding and oxoG recognition site [nucleotide binding]
563178002090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924
563178002091	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
563178002092	hypothetical protein; Provisional; Region: PRK05423
563178002093	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
563178002094	active site
563178002095	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
563178002096	trimer interface [polypeptide binding]; other site
563178002097	active site
563178002098	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
563178002099	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
563178002100	active site
563178002101	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
563178002102	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
563178002103	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
563178002104	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
563178002105	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
563178002106	ribonuclease R; Region: RNase_R; TIGR02063
563178002107	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
563178002108	RNB domain; Region: RNB; pfam00773
563178002109	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
563178002110	RNA binding site [nucleotide binding]; other site
563178002111	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
563178002112	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
563178002113	GDP-binding site [chemical binding]; other site
563178002114	ACT binding site; other site
563178002115	IMP binding site; other site
563178002116	FtsH protease regulator HflC; Provisional; Region: PRK11029
563178002117	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
563178002118	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
563178002119	HflK protein; Region: hflK; TIGR01933
563178002120	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
563178002121	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
563178002122	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
563178002123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
563178002124	ATP binding site [chemical binding]; other site
563178002125	Mg2+ binding site [ion binding]; other site
563178002126	G-X-G motif; other site
563178002127	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
563178002128	ATP binding site [chemical binding]; other site
563178002129	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
563178002130	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
563178002131	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
563178002132	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
563178002133	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
563178002134	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
563178002135	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
563178002136	active site
563178002137	P-loop; other site
563178002138	phosphorylation site [posttranslational modification]
563178002139	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
563178002140	active site
563178002141	phosphorylation site [posttranslational modification]
563178002142	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
563178002143	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
563178002144	active site
563178002145	dimer interface [polypeptide binding]; other site
563178002146	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
563178002147	dimer interface [polypeptide binding]; other site
563178002148	active site
563178002149	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
563178002150	catalytic site [active]
563178002151	putative active site [active]
563178002152	putative substrate binding site [chemical binding]; other site
563178002153	dimer interface [polypeptide binding]; other site
563178002154	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
563178002155	active site
563178002156	metal binding site [ion binding]; metal-binding site
563178002157	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
563178002158	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
563178002159	active site
563178002160	HslU subunit interaction site [polypeptide binding]; other site
563178002161	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
563178002162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
563178002163	Walker A motif; other site
563178002164	ATP binding site [chemical binding]; other site
563178002165	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
563178002166	Walker B motif; other site
563178002167	arginine finger; other site
563178002168	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
563178002169	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
563178002170	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
563178002171	putative dimer interface [polypeptide binding]; other site
563178002172	ferredoxin-NADP reductase; Provisional; Region: PRK10926
563178002173	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
563178002174	FAD binding pocket [chemical binding]; other site
563178002175	FAD binding motif [chemical binding]; other site
563178002176	phosphate binding motif [ion binding]; other site
563178002177	beta-alpha-beta structure motif; other site
563178002178	NAD binding pocket [chemical binding]; other site
563178002179	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
563178002180	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
563178002181	motif 1; other site
563178002182	dimer interface [polypeptide binding]; other site
563178002183	active site
563178002184	motif 2; other site
563178002185	motif 3; other site
563178002186	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
563178002187	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
563178002188	active site
563178002189	(T/H)XGH motif; other site
563178002190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
563178002191	S-adenosylmethionine binding site [chemical binding]; other site
563178002192	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
563178002193	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
563178002194	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
563178002195	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
563178002196	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
563178002197	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
563178002198	putative iron binding site [ion binding]; other site
563178002199	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
563178002200	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
563178002201	domain interfaces; other site
563178002202	active site
563178002203	transcription termination factor Rho; Provisional; Region: rho; PRK09376
563178002204	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
563178002205	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
563178002206	RNA binding site [nucleotide binding]; other site
563178002207	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
563178002208	multimer interface [polypeptide binding]; other site
563178002209	Walker A motif; other site
563178002210	ATP binding site [chemical binding]; other site
563178002211	Walker B motif; other site
563178002212	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
563178002213	catalytic residues [active]
563178002214	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
563178002215	Part of AAA domain; Region: AAA_19; pfam13245
563178002216	Family description; Region: UvrD_C_2; pfam13538
563178002217	ketol-acid reductoisomerase; Validated; Region: PRK05225
563178002218	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
563178002219	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
563178002220	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
563178002221	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
563178002222	cysteine desulfurase; Provisional; Region: PRK14012
563178002223	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
563178002224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
563178002225	catalytic residue [active]
563178002226	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
563178002227	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
563178002228	trimerization site [polypeptide binding]; other site
563178002229	active site
563178002230	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
563178002231	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
563178002232	Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991
563178002233	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
563178002234	nucleotide binding site [chemical binding]; other site
563178002235	putative NEF/HSP70 interaction site [polypeptide binding]; other site
563178002236	SBD interface [polypeptide binding]; other site
563178002237	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
563178002238	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
563178002239	catalytic loop [active]
563178002240	iron binding site [ion binding]; other site
563178002241	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
563178002242	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
563178002243	G1 box; other site
563178002244	GTP/Mg2+ binding site [chemical binding]; other site
563178002245	Switch I region; other site
563178002246	G2 box; other site
563178002247	Switch II region; other site
563178002248	G3 box; other site
563178002249	G4 box; other site
563178002250	G5 box; other site
563178002251	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
563178002252	G1 box; other site
563178002253	GTP/Mg2+ binding site [chemical binding]; other site
563178002254	Switch I region; other site
563178002255	G2 box; other site
563178002256	G3 box; other site
563178002257	Switch II region; other site
563178002258	G4 box; other site
563178002259	G5 box; other site
563178002260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976