-- dump date 20140619_005107 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1045858000001 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045858000002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045858000003 ligand binding site [chemical binding]; other site 1045858000004 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045858000005 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045858000006 ligand binding site [chemical binding]; other site 1045858000007 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1045858000008 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1045858000009 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1045858000010 Response regulator receiver domain; Region: Response_reg; pfam00072 1045858000011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858000012 active site 1045858000013 phosphorylation site [posttranslational modification] 1045858000014 intermolecular recognition site; other site 1045858000015 dimerization interface [polypeptide binding]; other site 1045858000016 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045858000017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045858000018 metal binding site [ion binding]; metal-binding site 1045858000019 active site 1045858000020 I-site; other site 1045858000021 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045858000022 EamA-like transporter family; Region: EamA; pfam00892 1045858000023 EamA-like transporter family; Region: EamA; pfam00892 1045858000024 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1045858000025 diiron binding motif [ion binding]; other site 1045858000026 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 1045858000027 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1045858000028 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1045858000029 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1045858000030 active site 1045858000031 HIGH motif; other site 1045858000032 KMSK motif region; other site 1045858000033 tRNA binding surface [nucleotide binding]; other site 1045858000034 DALR anticodon binding domain; Region: DALR_1; smart00836 1045858000035 anticodon binding site; other site 1045858000036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045858000037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1045858000038 DNA binding residues [nucleotide binding] 1045858000039 dimerization interface [polypeptide binding]; other site 1045858000040 Predicted methyltransferases [General function prediction only]; Region: COG0313 1045858000041 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1045858000042 putative homodimer interface [polypeptide binding]; other site 1045858000043 putative SAM binding site [chemical binding]; other site 1045858000044 TonB C terminal; Region: TonB_2; pfam13103 1045858000045 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1045858000046 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 1045858000047 putative active site [active] 1045858000048 metal binding site [ion binding]; metal-binding site 1045858000049 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1045858000050 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1045858000051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858000052 TPR motif; other site 1045858000053 binding surface 1045858000054 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1045858000055 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1045858000056 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1045858000057 homodimer interface [polypeptide binding]; other site 1045858000058 NADP binding site [chemical binding]; other site 1045858000059 substrate binding site [chemical binding]; other site 1045858000060 Predicted membrane protein [Function unknown]; Region: COG2510 1045858000061 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1045858000062 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1045858000063 dimer interface [polypeptide binding]; other site 1045858000064 active site residues [active] 1045858000065 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1045858000066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045858000067 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1045858000068 NAD binding site [chemical binding]; other site 1045858000069 putative substrate binding site 2 [chemical binding]; other site 1045858000070 putative substrate binding site 1 [chemical binding]; other site 1045858000071 active site 1045858000072 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1045858000073 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045858000074 metal-binding site [ion binding] 1045858000075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045858000076 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045858000077 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1045858000078 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1045858000079 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1045858000080 Walker A/P-loop; other site 1045858000081 ATP binding site [chemical binding]; other site 1045858000082 Q-loop/lid; other site 1045858000083 ABC transporter signature motif; other site 1045858000084 Walker B; other site 1045858000085 D-loop; other site 1045858000086 H-loop/switch region; other site 1045858000087 NIL domain; Region: NIL; pfam09383 1045858000088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858000089 conserved gate region; other site 1045858000090 ABC-ATPase subunit interface; other site 1045858000091 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1045858000092 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045858000093 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1045858000094 NAD binding site [chemical binding]; other site 1045858000095 dimer interface [polypeptide binding]; other site 1045858000096 substrate binding site [chemical binding]; other site 1045858000097 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1045858000098 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1045858000099 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1045858000100 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1045858000101 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1045858000102 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1045858000103 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1045858000104 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1045858000105 active pocket/dimerization site; other site 1045858000106 active site 1045858000107 phosphorylation site [posttranslational modification] 1045858000108 Beta-lactamase; Region: Beta-lactamase; pfam00144 1045858000109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1045858000110 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1045858000111 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1045858000112 putative active site [active] 1045858000113 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1045858000114 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1045858000115 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1045858000116 putative active site [active] 1045858000117 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1045858000118 active site 1045858000119 phosphorylation site [posttranslational modification] 1045858000120 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1045858000121 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1045858000122 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858000123 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1045858000124 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858000125 putative efflux protein, MATE family; Region: matE; TIGR00797 1045858000126 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1045858000127 Family description; Region: UvrD_C_2; pfam13538 1045858000128 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858000129 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858000130 peptide binding site [polypeptide binding]; other site 1045858000131 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858000132 4Fe-4S binding domain; Region: Fer4; pfam00037 1045858000133 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 1045858000134 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1045858000135 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1045858000136 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1045858000137 GDP-binding site [chemical binding]; other site 1045858000138 ACT binding site; other site 1045858000139 IMP binding site; other site 1045858000140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000141 binding surface 1045858000142 TPR motif; other site 1045858000143 TPR repeat; Region: TPR_11; pfam13414 1045858000144 Protein of unknown function (DUF2806); Region: DUF2806; pfam10987 1045858000145 Predicted chitinase [General function prediction only]; Region: COG3179 1045858000146 catalytic residue [active] 1045858000147 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 1045858000148 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1045858000149 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1045858000150 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1045858000151 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 1045858000152 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1045858000153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045858000154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045858000155 non-specific DNA binding site [nucleotide binding]; other site 1045858000156 salt bridge; other site 1045858000157 sequence-specific DNA binding site [nucleotide binding]; other site 1045858000158 Predicted transcriptional regulator [Transcription]; Region: COG2932 1045858000159 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045858000160 Catalytic site [active] 1045858000161 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1045858000162 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1045858000163 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1045858000164 TMPIT-like protein; Region: TMPIT; pfam07851 1045858000165 Integrase core domain; Region: rve; pfam00665 1045858000166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858000167 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1045858000168 AAA ATPase domain; Region: AAA_16; pfam13191 1045858000169 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 1045858000170 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1045858000171 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 1045858000172 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1045858000173 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1045858000174 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1045858000175 Phage tail tube protein; Region: Tail_tube; pfam10618 1045858000176 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1045858000177 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1045858000178 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1045858000179 Phage protein GP46; Region: GP46; cl01814 1045858000180 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1045858000181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000182 TPR motif; other site 1045858000183 TPR repeat; Region: TPR_11; pfam13414 1045858000184 binding surface 1045858000185 TPR repeat; Region: TPR_11; pfam13414 1045858000186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000187 binding surface 1045858000188 TPR motif; other site 1045858000189 TPR repeat; Region: TPR_11; pfam13414 1045858000190 TPR repeat; Region: TPR_11; pfam13414 1045858000191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000192 binding surface 1045858000193 TPR motif; other site 1045858000194 TPR repeat; Region: TPR_11; pfam13414 1045858000195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000196 binding surface 1045858000197 TPR repeat; Region: TPR_11; pfam13414 1045858000198 TPR motif; other site 1045858000199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858000200 dimerization interface [polypeptide binding]; other site 1045858000201 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000202 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000203 dimer interface [polypeptide binding]; other site 1045858000204 putative CheW interface [polypeptide binding]; other site 1045858000205 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 1045858000206 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1045858000207 putative active site [active] 1045858000208 metal binding site [ion binding]; metal-binding site 1045858000209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000210 binding surface 1045858000211 TPR motif; other site 1045858000212 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1045858000213 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1045858000214 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1045858000215 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045858000216 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1045858000217 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 1045858000218 Domain of unknown function (DUF955); Region: DUF955; cl01076 1045858000219 CTP synthase; Region: PyrG; TIGR00337 1045858000220 Predicted chitinase [General function prediction only]; Region: COG3179 1045858000221 catalytic residue [active] 1045858000222 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858000223 dimerization interface [polypeptide binding]; other site 1045858000224 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000226 dimer interface [polypeptide binding]; other site 1045858000227 putative CheW interface [polypeptide binding]; other site 1045858000228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858000229 dimerization interface [polypeptide binding]; other site 1045858000230 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000231 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000232 dimer interface [polypeptide binding]; other site 1045858000233 putative CheW interface [polypeptide binding]; other site 1045858000234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858000235 dimerization interface [polypeptide binding]; other site 1045858000236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000238 dimer interface [polypeptide binding]; other site 1045858000239 putative CheW interface [polypeptide binding]; other site 1045858000240 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1045858000241 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1045858000242 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045858000243 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1045858000244 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1045858000245 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045858000246 tetramer interface [polypeptide binding]; other site 1045858000247 catalytic Zn binding site [ion binding]; other site 1045858000248 NADP binding site [chemical binding]; other site 1045858000249 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858000250 Thymidine kinase; Region: TK; pfam00265 1045858000251 Protein of unknown function (DUF511); Region: DUF511; cl01114 1045858000252 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1045858000253 Peptidase family U32; Region: Peptidase_U32; pfam01136 1045858000254 Collagenase; Region: DUF3656; pfam12392 1045858000255 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1045858000256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045858000257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045858000258 acyl-activating enzyme (AAE) consensus motif; other site 1045858000259 AMP binding site [chemical binding]; other site 1045858000260 active site 1045858000261 CoA binding site [chemical binding]; other site 1045858000262 Haemolysin-III related; Region: HlyIII; cl03831 1045858000263 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1045858000264 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1045858000265 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045858000266 DinB family; Region: DinB; cl17821 1045858000267 DinB superfamily; Region: DinB_2; pfam12867 1045858000268 RecX family; Region: RecX; cl00936 1045858000269 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045858000270 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045858000271 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1045858000272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858000273 Walker A motif; other site 1045858000274 ATP binding site [chemical binding]; other site 1045858000275 Walker B motif; other site 1045858000276 arginine finger; other site 1045858000277 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1045858000278 Cache domain; Region: Cache_1; pfam02743 1045858000279 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000281 dimer interface [polypeptide binding]; other site 1045858000282 putative CheW interface [polypeptide binding]; other site 1045858000283 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1045858000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858000285 Walker A motif; other site 1045858000286 ATP binding site [chemical binding]; other site 1045858000287 Walker B motif; other site 1045858000288 arginine finger; other site 1045858000289 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1045858000290 inner membrane protein; Provisional; Region: PRK11715 1045858000291 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1045858000292 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1045858000293 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045858000294 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858000295 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858000296 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1045858000297 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858000298 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1045858000299 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1045858000300 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1045858000301 active site 1045858000302 TPR repeat; Region: TPR_11; pfam13414 1045858000303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000304 binding surface 1045858000305 TPR motif; other site 1045858000306 TPR repeat; Region: TPR_11; pfam13414 1045858000307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000308 binding surface 1045858000309 TPR motif; other site 1045858000310 TPR repeat; Region: TPR_11; pfam13414 1045858000311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000312 binding surface 1045858000313 TPR motif; other site 1045858000314 TPR repeat; Region: TPR_11; pfam13414 1045858000315 Cache domain; Region: Cache_1; pfam02743 1045858000316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000317 dimer interface [polypeptide binding]; other site 1045858000318 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1045858000319 putative CheW interface [polypeptide binding]; other site 1045858000320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858000321 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045858000322 Walker A motif; other site 1045858000323 ATP binding site [chemical binding]; other site 1045858000324 Walker B motif; other site 1045858000325 arginine finger; other site 1045858000326 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1045858000327 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1045858000328 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1045858000329 dimer interface [polypeptide binding]; other site 1045858000330 ssDNA binding site [nucleotide binding]; other site 1045858000331 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045858000332 thymidylate kinase; Validated; Region: tmk; PRK00698 1045858000333 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1045858000334 TMP-binding site; other site 1045858000335 ATP-binding site [chemical binding]; other site 1045858000336 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1045858000337 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1045858000338 Mg++ binding site [ion binding]; other site 1045858000339 putative catalytic motif [active] 1045858000340 putative substrate binding site [chemical binding]; other site 1045858000341 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1045858000342 Rubredoxin [Energy production and conversion]; Region: COG1773 1045858000343 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045858000344 iron binding site [ion binding]; other site 1045858000345 Rubredoxin [Energy production and conversion]; Region: COG1773 1045858000346 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045858000347 iron binding site [ion binding]; other site 1045858000348 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858000349 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858000350 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858000351 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858000352 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1045858000353 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1045858000354 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1045858000355 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1045858000356 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1045858000357 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1045858000358 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1045858000359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858000360 Walker A/P-loop; other site 1045858000361 ATP binding site [chemical binding]; other site 1045858000362 Q-loop/lid; other site 1045858000363 ABC transporter signature motif; other site 1045858000364 Walker B; other site 1045858000365 D-loop; other site 1045858000366 H-loop/switch region; other site 1045858000367 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1045858000368 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045858000369 ABC-ATPase subunit interface; other site 1045858000370 dimer interface [polypeptide binding]; other site 1045858000371 putative PBP binding regions; other site 1045858000372 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1045858000373 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1045858000374 intersubunit interface [polypeptide binding]; other site 1045858000375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000376 binding surface 1045858000377 TPR motif; other site 1045858000378 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858000379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000381 binding surface 1045858000382 TPR motif; other site 1045858000383 TPR repeat; Region: TPR_11; pfam13414 1045858000384 TPR repeat; Region: TPR_11; pfam13414 1045858000385 TPR repeat; Region: TPR_11; pfam13414 1045858000386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000387 TPR motif; other site 1045858000388 binding surface 1045858000389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000391 binding surface 1045858000392 TPR motif; other site 1045858000393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000394 TPR repeat; Region: TPR_11; pfam13414 1045858000395 binding surface 1045858000396 TPR motif; other site 1045858000397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000398 binding surface 1045858000399 TPR motif; other site 1045858000400 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858000401 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1045858000402 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1045858000403 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045858000404 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045858000405 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1045858000406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000407 binding surface 1045858000408 TPR motif; other site 1045858000409 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1045858000410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000411 binding surface 1045858000412 TPR motif; other site 1045858000413 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1045858000414 TPR repeat; Region: TPR_11; pfam13414 1045858000415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858000416 dimerization interface [polypeptide binding]; other site 1045858000417 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000419 dimer interface [polypeptide binding]; other site 1045858000420 putative CheW interface [polypeptide binding]; other site 1045858000421 recombination factor protein RarA; Reviewed; Region: PRK13342 1045858000422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858000423 Walker A motif; other site 1045858000424 ATP binding site [chemical binding]; other site 1045858000425 Walker B motif; other site 1045858000426 arginine finger; other site 1045858000427 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1045858000428 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1045858000429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1045858000430 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858000431 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1045858000432 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858000433 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1045858000434 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1045858000435 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1045858000436 active site 1045858000437 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045858000438 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1045858000439 putative NAD(P) binding site [chemical binding]; other site 1045858000440 putative substrate binding site [chemical binding]; other site 1045858000441 catalytic Zn binding site [ion binding]; other site 1045858000442 structural Zn binding site [ion binding]; other site 1045858000443 dimer interface [polypeptide binding]; other site 1045858000444 Atrophin-1 family; Region: Atrophin-1; pfam03154 1045858000445 seryl-tRNA synthetase; Provisional; Region: PRK05431 1045858000446 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1045858000447 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1045858000448 dimer interface [polypeptide binding]; other site 1045858000449 active site 1045858000450 motif 1; other site 1045858000451 motif 2; other site 1045858000452 motif 3; other site 1045858000453 TfoX N-terminal domain; Region: TfoX_N; cl17592 1045858000454 TPR repeat; Region: TPR_11; pfam13414 1045858000455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000456 binding surface 1045858000457 TPR motif; other site 1045858000458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000459 TPR repeat; Region: TPR_11; pfam13414 1045858000460 binding surface 1045858000461 TPR motif; other site 1045858000462 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1045858000463 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1045858000464 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1045858000465 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1045858000466 putative NAD(P) binding site [chemical binding]; other site 1045858000467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858000468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858000469 active site 1045858000470 catalytic tetrad [active] 1045858000471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858000472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045858000473 putative substrate translocation pore; other site 1045858000474 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 1045858000475 SxDxEG motif; other site 1045858000476 putative active site [active] 1045858000477 putative metal binding site [ion binding]; other site 1045858000478 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1045858000479 nudix motif; other site 1045858000480 AAA domain; Region: AAA_33; pfam13671 1045858000481 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045858000482 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1045858000483 active site 1045858000484 metal binding site [ion binding]; metal-binding site 1045858000485 RNA ligase; Region: RNA_lig_T4_1; pfam09511 1045858000486 TPR repeat; Region: TPR_11; pfam13414 1045858000487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000488 binding surface 1045858000489 TPR motif; other site 1045858000490 TPR repeat; Region: TPR_11; pfam13414 1045858000491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000492 binding surface 1045858000493 TPR motif; other site 1045858000494 TPR repeat; Region: TPR_11; pfam13414 1045858000495 TPR repeat; Region: TPR_11; pfam13414 1045858000496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000497 binding surface 1045858000498 TPR motif; other site 1045858000499 TPR repeat; Region: TPR_11; pfam13414 1045858000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000501 binding surface 1045858000502 TPR motif; other site 1045858000503 TPR repeat; Region: TPR_11; pfam13414 1045858000504 TPR repeat; Region: TPR_11; pfam13414 1045858000505 DHH family; Region: DHH; pfam01368 1045858000506 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1045858000507 DHHA1 domain; Region: DHHA1; pfam02272 1045858000508 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1045858000509 generic binding surface I; other site 1045858000510 generic binding surface II; other site 1045858000511 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858000512 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858000513 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858000514 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858000515 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858000516 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858000517 MoxR-like ATPases [General function prediction only]; Region: COG0714 1045858000518 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1045858000519 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045858000520 EamA-like transporter family; Region: EamA; pfam00892 1045858000521 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1045858000522 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 1045858000523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000524 binding surface 1045858000525 TPR motif; other site 1045858000526 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1045858000527 anti sigma factor interaction site; other site 1045858000528 regulatory phosphorylation site [posttranslational modification]; other site 1045858000529 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 1045858000530 active site 1045858000531 putative catalytic site [active] 1045858000532 phosphate binding site A [ion binding]; other site 1045858000533 DNA binding site [nucleotide binding] 1045858000534 metal binding site A [ion binding]; metal-binding site 1045858000535 putative AP binding site [nucleotide binding]; other site 1045858000536 putative metal binding site B [ion binding]; other site 1045858000537 phosphate binding site B [ion binding]; other site 1045858000538 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1045858000539 Cache domain; Region: Cache_1; pfam02743 1045858000540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858000541 dimerization interface [polypeptide binding]; other site 1045858000542 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000543 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000544 dimer interface [polypeptide binding]; other site 1045858000545 putative CheW interface [polypeptide binding]; other site 1045858000546 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1045858000547 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1045858000548 active site 1045858000549 HIGH motif; other site 1045858000550 KMSKS motif; other site 1045858000551 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1045858000552 tRNA binding surface [nucleotide binding]; other site 1045858000553 anticodon binding site; other site 1045858000554 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1045858000555 dimer interface [polypeptide binding]; other site 1045858000556 putative tRNA-binding site [nucleotide binding]; other site 1045858000557 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1045858000558 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858000559 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1045858000560 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1045858000561 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1045858000562 dimer interface [polypeptide binding]; other site 1045858000563 active site 1045858000564 CoA binding pocket [chemical binding]; other site 1045858000565 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 1045858000566 Protein of unknown function DUF45; Region: DUF45; pfam01863 1045858000567 HAMP domain; Region: HAMP; pfam00672 1045858000568 dimerization interface [polypeptide binding]; other site 1045858000569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858000570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858000571 dimer interface [polypeptide binding]; other site 1045858000572 putative CheW interface [polypeptide binding]; other site 1045858000573 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1045858000574 active site 1045858000575 Zn binding site [ion binding]; other site 1045858000576 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858000577 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1045858000578 Transglycosylase; Region: Transgly; pfam00912 1045858000579 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1045858000580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045858000581 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1045858000582 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858000583 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1045858000584 substrate binding site; other site 1045858000585 dimer interface; other site 1045858000586 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1045858000587 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1045858000588 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 1045858000589 ADP binding site [chemical binding]; other site 1045858000590 phosphagen binding site; other site 1045858000591 substrate specificity loop; other site 1045858000592 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1045858000593 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1045858000594 FAD binding pocket [chemical binding]; other site 1045858000595 FAD binding motif [chemical binding]; other site 1045858000596 phosphate binding motif [ion binding]; other site 1045858000597 beta-alpha-beta structure motif; other site 1045858000598 NAD binding pocket [chemical binding]; other site 1045858000599 Iron coordination center [ion binding]; other site 1045858000600 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1045858000601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045858000602 DNA binding site [nucleotide binding] 1045858000603 domain linker motif; other site 1045858000604 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1045858000605 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045858000606 ligand binding site [chemical binding]; other site 1045858000607 LemA family; Region: LemA; cl00742 1045858000608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858000609 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045858000610 substrate binding pocket [chemical binding]; other site 1045858000611 membrane-bound complex binding site; other site 1045858000612 hinge residues; other site 1045858000613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858000614 dimer interface [polypeptide binding]; other site 1045858000615 conserved gate region; other site 1045858000616 putative PBP binding loops; other site 1045858000617 ABC-ATPase subunit interface; other site 1045858000618 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045858000619 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045858000620 Walker A/P-loop; other site 1045858000621 ATP binding site [chemical binding]; other site 1045858000622 Q-loop/lid; other site 1045858000623 ABC transporter signature motif; other site 1045858000624 Walker B; other site 1045858000625 D-loop; other site 1045858000626 H-loop/switch region; other site 1045858000627 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1045858000628 Peptidase family M50; Region: Peptidase_M50; pfam02163 1045858000629 active site 1045858000630 putative substrate binding region [chemical binding]; other site 1045858000631 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 1045858000632 YtxH-like protein; Region: YtxH; pfam12732 1045858000633 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045858000634 CoenzymeA binding site [chemical binding]; other site 1045858000635 subunit interaction site [polypeptide binding]; other site 1045858000636 PHB binding site; other site 1045858000637 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 1045858000638 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 1045858000639 Ligand Binding Site [chemical binding]; other site 1045858000640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858000641 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1045858000642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858000643 active site 1045858000644 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045858000645 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1045858000646 TM-ABC transporter signature motif; other site 1045858000647 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045858000648 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1045858000649 TM-ABC transporter signature motif; other site 1045858000650 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858000651 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1045858000652 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045858000653 Walker A/P-loop; other site 1045858000654 ATP binding site [chemical binding]; other site 1045858000655 Q-loop/lid; other site 1045858000656 ABC transporter signature motif; other site 1045858000657 Walker B; other site 1045858000658 D-loop; other site 1045858000659 H-loop/switch region; other site 1045858000660 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045858000661 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1045858000662 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1045858000663 ligand binding site [chemical binding]; other site 1045858000664 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1045858000665 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1045858000666 ligand binding site [chemical binding]; other site 1045858000667 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1045858000668 ligand binding site [chemical binding]; other site 1045858000669 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1045858000670 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1045858000671 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1045858000672 ligand binding site [chemical binding]; other site 1045858000673 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1045858000674 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1045858000675 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1045858000676 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1045858000677 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1045858000678 intersubunit interface [polypeptide binding]; other site 1045858000679 active site 1045858000680 catalytic residue [active] 1045858000681 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1045858000682 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045858000683 inhibitor-cofactor binding pocket; inhibition site 1045858000684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858000685 catalytic residue [active] 1045858000686 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1045858000687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1045858000688 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1045858000689 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1045858000690 dimer interface [polypeptide binding]; other site 1045858000691 ADP-ribose binding site [chemical binding]; other site 1045858000692 active site 1045858000693 nudix motif; other site 1045858000694 metal binding site [ion binding]; metal-binding site 1045858000695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045858000696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045858000697 dimer interface [polypeptide binding]; other site 1045858000698 phosphorylation site [posttranslational modification] 1045858000699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858000700 ATP binding site [chemical binding]; other site 1045858000701 Mg2+ binding site [ion binding]; other site 1045858000702 G-X-G motif; other site 1045858000703 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1045858000704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1045858000705 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1045858000706 membrane protein insertase; Provisional; Region: PRK01318 1045858000707 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1045858000708 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1045858000709 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1045858000710 G-X-X-G motif; other site 1045858000711 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1045858000712 RxxxH motif; other site 1045858000713 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1045858000714 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1045858000715 NAD binding site [chemical binding]; other site 1045858000716 homodimer interface [polypeptide binding]; other site 1045858000717 active site 1045858000718 substrate binding site [chemical binding]; other site 1045858000719 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1045858000720 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1045858000721 putative substrate binding site [chemical binding]; other site 1045858000722 putative ATP binding site [chemical binding]; other site 1045858000723 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1045858000724 active site 1045858000725 putative DNA-binding cleft [nucleotide binding]; other site 1045858000726 dimer interface [polypeptide binding]; other site 1045858000727 hypothetical protein; Validated; Region: PRK00110 1045858000728 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1045858000729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045858000730 active site 1045858000731 metal binding site [ion binding]; metal-binding site 1045858000732 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1045858000733 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1045858000734 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045858000735 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1045858000736 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1045858000737 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1045858000738 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1045858000739 homodimer interface [polypeptide binding]; other site 1045858000740 substrate-cofactor binding pocket; other site 1045858000741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858000742 catalytic residue [active] 1045858000743 Protein of unknown function DUF262; Region: DUF262; pfam03235 1045858000744 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1045858000745 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1045858000746 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1045858000747 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1045858000748 thiamine phosphate binding site [chemical binding]; other site 1045858000749 active site 1045858000750 pyrophosphate binding site [ion binding]; other site 1045858000751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000752 binding surface 1045858000753 TPR motif; other site 1045858000754 TPR repeat; Region: TPR_11; pfam13414 1045858000755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000756 binding surface 1045858000757 TPR motif; other site 1045858000758 TPR repeat; Region: TPR_11; pfam13414 1045858000759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000760 binding surface 1045858000761 TPR motif; other site 1045858000762 TPR repeat; Region: TPR_11; pfam13414 1045858000763 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000765 binding surface 1045858000766 TPR motif; other site 1045858000767 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000769 binding surface 1045858000770 TPR motif; other site 1045858000771 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858000772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000773 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858000774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858000775 binding surface 1045858000776 TPR motif; other site 1045858000777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858000780 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1045858000781 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1045858000782 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1045858000783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858000784 S-adenosylmethionine binding site [chemical binding]; other site 1045858000785 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1045858000786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858000787 active site 1045858000788 motif I; other site 1045858000789 motif II; other site 1045858000790 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1045858000791 dimer interface [polypeptide binding]; other site 1045858000792 catalytic triad [active] 1045858000793 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1045858000794 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1045858000795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858000796 FeS/SAM binding site; other site 1045858000797 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 1045858000798 AAA domain; Region: AAA_17; pfam13207 1045858000799 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 1045858000800 active site 1045858000801 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1045858000802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045858000803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858000804 catalytic residue [active] 1045858000805 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1045858000806 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045858000807 putative active site [active] 1045858000808 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1045858000809 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1045858000810 TMP-binding site; other site 1045858000811 ATP-binding site [chemical binding]; other site 1045858000812 RIP metalloprotease RseP; Region: TIGR00054 1045858000813 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1045858000814 active site 1045858000815 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1045858000816 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1045858000817 protein binding site [polypeptide binding]; other site 1045858000818 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1045858000819 putative substrate binding region [chemical binding]; other site 1045858000820 CHAT domain; Region: CHAT; cl17868 1045858000821 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1045858000822 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1045858000823 amidase catalytic site [active] 1045858000824 Zn binding residues [ion binding]; other site 1045858000825 substrate binding site [chemical binding]; other site 1045858000826 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1045858000827 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1045858000828 active site 1045858000829 homodimer interface [polypeptide binding]; other site 1045858000830 SAM binding site [chemical binding]; other site 1045858000831 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1045858000832 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1045858000833 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045858000834 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858000835 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1045858000836 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858000837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045858000838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858000839 NAD(P) binding site [chemical binding]; other site 1045858000840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858000841 active site 1045858000842 flavodoxin; Provisional; Region: PRK06242 1045858000843 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1045858000844 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045858000845 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1045858000846 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1045858000847 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1045858000848 dimer interface [polypeptide binding]; other site 1045858000849 active site 1045858000850 CoA binding pocket [chemical binding]; other site 1045858000851 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 1045858000852 HEAT repeats; Region: HEAT_2; pfam13646 1045858000853 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1045858000854 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1045858000855 motif 1; other site 1045858000856 active site 1045858000857 motif 2; other site 1045858000858 motif 3; other site 1045858000859 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1045858000860 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1045858000861 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1045858000862 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045858000863 protein binding site [polypeptide binding]; other site 1045858000864 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1045858000865 protein binding site [polypeptide binding]; other site 1045858000866 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1045858000867 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045858000868 putative acyl-acceptor binding pocket; other site 1045858000869 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1045858000870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858000871 NAD(P) binding site [chemical binding]; other site 1045858000872 active site 1045858000873 LPP20 lipoprotein; Region: LPP20; cl15824 1045858000874 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1045858000875 interface (dimer of trimers) [polypeptide binding]; other site 1045858000876 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1045858000877 Substrate-binding/catalytic site; other site 1045858000878 Zn-binding sites [ion binding]; other site 1045858000879 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1045858000880 putative dimer interface [polypeptide binding]; other site 1045858000881 [2Fe-2S] cluster binding site [ion binding]; other site 1045858000882 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1045858000883 SLBB domain; Region: SLBB; pfam10531 1045858000884 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1045858000885 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1045858000886 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1045858000887 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1045858000888 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1045858000889 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1045858000890 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1045858000891 putative active site [active] 1045858000892 oxyanion strand; other site 1045858000893 catalytic triad [active] 1045858000894 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1045858000895 putative active site pocket [active] 1045858000896 4-fold oligomerization interface [polypeptide binding]; other site 1045858000897 metal binding residues [ion binding]; metal-binding site 1045858000898 3-fold/trimer interface [polypeptide binding]; other site 1045858000899 glycerate kinase; Region: TIGR00045 1045858000900 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1045858000901 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1045858000902 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1045858000903 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1045858000904 Na2 binding site [ion binding]; other site 1045858000905 putative substrate binding site 1 [chemical binding]; other site 1045858000906 Na binding site 1 [ion binding]; other site 1045858000907 putative substrate binding site 2 [chemical binding]; other site 1045858000908 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858000909 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1045858000910 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1045858000911 Peptidase family M28; Region: Peptidase_M28; pfam04389 1045858000912 metal binding site [ion binding]; metal-binding site 1045858000913 flagellin; Provisional; Region: PRK12804 1045858000914 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045858000915 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1045858000916 fumarate hydratase; Provisional; Region: PRK06246 1045858000917 Fumarase C-terminus; Region: Fumerase_C; cl00795 1045858000918 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1045858000919 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1045858000920 nucleotidyl binding site; other site 1045858000921 metal binding site [ion binding]; metal-binding site 1045858000922 translation initiation factor IF-2; Region: IF-2; TIGR00487 1045858000923 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1045858000924 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1045858000925 G1 box; other site 1045858000926 putative GEF interaction site [polypeptide binding]; other site 1045858000927 GTP/Mg2+ binding site [chemical binding]; other site 1045858000928 Switch I region; other site 1045858000929 G2 box; other site 1045858000930 G3 box; other site 1045858000931 Switch II region; other site 1045858000932 G4 box; other site 1045858000933 G5 box; other site 1045858000934 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1045858000935 Translation-initiation factor 2; Region: IF-2; pfam11987 1045858000936 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1045858000937 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1045858000938 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1045858000939 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1045858000940 dimerization interface [polypeptide binding]; other site 1045858000941 putative ATP binding site [chemical binding]; other site 1045858000942 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1045858000943 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1045858000944 active site 1045858000945 substrate binding site [chemical binding]; other site 1045858000946 cosubstrate binding site; other site 1045858000947 catalytic site [active] 1045858000948 Putative zinc-finger; Region: zf-HC2; pfam13490 1045858000949 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1045858000950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045858000951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858000952 DNA binding residues [nucleotide binding] 1045858000953 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1045858000954 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858000955 Protein export membrane protein; Region: SecD_SecF; cl14618 1045858000956 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1045858000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858000958 S-adenosylmethionine binding site [chemical binding]; other site 1045858000959 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1045858000960 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1045858000961 NeuB family; Region: NeuB; pfam03102 1045858000962 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1045858000963 NeuB binding interface [polypeptide binding]; other site 1045858000964 putative substrate binding site [chemical binding]; other site 1045858000965 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045858000966 FtsX-like permease family; Region: FtsX; pfam02687 1045858000967 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1045858000968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045858000969 FtsX-like permease family; Region: FtsX; pfam02687 1045858000970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045858000971 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045858000972 Walker A/P-loop; other site 1045858000973 ATP binding site [chemical binding]; other site 1045858000974 Q-loop/lid; other site 1045858000975 ABC transporter signature motif; other site 1045858000976 Walker B; other site 1045858000977 D-loop; other site 1045858000978 H-loop/switch region; other site 1045858000979 Flavoprotein; Region: Flavoprotein; pfam02441 1045858000980 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1045858000981 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1045858000982 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1045858000983 PhoH-like protein; Region: PhoH; pfam02562 1045858000984 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1045858000985 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858000986 Zn2+ binding site [ion binding]; other site 1045858000987 Mg2+ binding site [ion binding]; other site 1045858000988 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1045858000989 FOG: CBS domain [General function prediction only]; Region: COG0517 1045858000990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045858000991 Transporter associated domain; Region: CorC_HlyC; smart01091 1045858000992 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1045858000993 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858000994 peptide binding site [polypeptide binding]; other site 1045858000995 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858000996 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858000997 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858000998 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858000999 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1045858001000 active site 1045858001001 metal binding site [ion binding]; metal-binding site 1045858001002 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045858001003 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1045858001004 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1045858001005 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1045858001006 active site 1045858001007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858001008 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858001009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001010 TPR motif; other site 1045858001011 binding surface 1045858001012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858001013 TPR repeat; Region: TPR_11; pfam13414 1045858001014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001015 binding surface 1045858001016 TPR motif; other site 1045858001017 TPR repeat; Region: TPR_11; pfam13414 1045858001018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001019 binding surface 1045858001020 TPR motif; other site 1045858001021 TPR repeat; Region: TPR_11; pfam13414 1045858001022 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1045858001023 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045858001024 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1045858001025 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045858001026 Flagellar protein (FlbD); Region: FlbD; pfam06289 1045858001027 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1045858001028 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1045858001029 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1045858001030 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045858001031 ligand binding site [chemical binding]; other site 1045858001032 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1045858001033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858001034 S-adenosylmethionine binding site [chemical binding]; other site 1045858001035 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1045858001036 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1045858001037 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045858001038 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045858001039 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045858001040 dimerization domain swap beta strand [polypeptide binding]; other site 1045858001041 regulatory protein interface [polypeptide binding]; other site 1045858001042 active site 1045858001043 regulatory phosphorylation site [posttranslational modification]; other site 1045858001044 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 1045858001045 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1045858001046 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1045858001047 active site 1045858001048 NTP binding site [chemical binding]; other site 1045858001049 metal binding triad [ion binding]; metal-binding site 1045858001050 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1045858001051 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1045858001052 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1045858001053 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1045858001054 Tetramer interface [polypeptide binding]; other site 1045858001055 active site 1045858001056 FMN-binding site [chemical binding]; other site 1045858001057 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1045858001058 active site 1045858001059 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1045858001060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858001061 motif II; other site 1045858001062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1045858001063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858001064 dimerization interface [polypeptide binding]; other site 1045858001065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858001066 ATP binding site [chemical binding]; other site 1045858001067 Mg2+ binding site [ion binding]; other site 1045858001068 G-X-G motif; other site 1045858001069 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1045858001070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858001071 Zn2+ binding site [ion binding]; other site 1045858001072 Mg2+ binding site [ion binding]; other site 1045858001073 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1045858001074 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1045858001075 SLBB domain; Region: SLBB; pfam10531 1045858001076 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1045858001077 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858001078 active site 1045858001079 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1045858001080 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1045858001081 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1045858001082 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1045858001083 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1045858001084 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1045858001085 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1045858001086 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1045858001087 metal binding site [ion binding]; metal-binding site 1045858001088 dimer interface [polypeptide binding]; other site 1045858001089 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1045858001090 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1045858001091 dimer interface [polypeptide binding]; other site 1045858001092 active site 1045858001093 catalytic residue [active] 1045858001094 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1045858001095 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1045858001096 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1045858001097 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1045858001098 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1045858001099 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1045858001100 trimer interface [polypeptide binding]; other site 1045858001101 active site 1045858001102 substrate binding site [chemical binding]; other site 1045858001103 CoA binding site [chemical binding]; other site 1045858001104 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1045858001105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858001106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858001107 homodimer interface [polypeptide binding]; other site 1045858001108 catalytic residue [active] 1045858001109 SWIM zinc finger; Region: SWIM; pfam04434 1045858001110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858001111 AAA domain; Region: AAA_21; pfam13304 1045858001112 Walker A/P-loop; other site 1045858001113 ATP binding site [chemical binding]; other site 1045858001114 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1045858001115 Protein export membrane protein; Region: SecD_SecF; cl14618 1045858001116 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1045858001117 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1045858001118 Preprotein translocase subunit; Region: YajC; pfam02699 1045858001119 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 1045858001120 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1045858001121 Cache domain; Region: Cache_1; pfam02743 1045858001122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858001123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001124 dimer interface [polypeptide binding]; other site 1045858001125 putative CheW interface [polypeptide binding]; other site 1045858001126 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1045858001127 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1045858001128 trimer interface [polypeptide binding]; other site 1045858001129 active site 1045858001130 UDP-GlcNAc binding site [chemical binding]; other site 1045858001131 lipid binding site [chemical binding]; lipid-binding site 1045858001132 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1045858001133 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1045858001134 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045858001135 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045858001136 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045858001137 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045858001138 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1045858001139 Surface antigen; Region: Bac_surface_Ag; pfam01103 1045858001140 Family of unknown function (DUF490); Region: DUF490; pfam04357 1045858001141 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858001142 active site 1045858001143 phosphorylation site [posttranslational modification] 1045858001144 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858001145 active site 1045858001146 phosphorylation site [posttranslational modification] 1045858001147 potential frameshift: common BLAST hit: gi|383328590|ref|YP_005354474.1| PTS system ascorbate-specific transporter subunit IIC 1045858001148 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1045858001149 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1045858001150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858001151 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1045858001152 active site 1045858001153 motif I; other site 1045858001154 motif II; other site 1045858001155 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045858001156 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1045858001157 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858001158 active site 1045858001159 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1045858001160 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1045858001161 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1045858001162 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1045858001163 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1045858001164 nudix motif; other site 1045858001165 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1045858001166 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1045858001167 Ligand Binding Site [chemical binding]; other site 1045858001168 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1045858001169 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1045858001170 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1045858001171 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1045858001172 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858001173 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1045858001174 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045858001175 catalytic core [active] 1045858001176 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1045858001177 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1045858001178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858001179 dimerization interface [polypeptide binding]; other site 1045858001180 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858001181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001182 dimer interface [polypeptide binding]; other site 1045858001183 putative CheW interface [polypeptide binding]; other site 1045858001184 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1045858001185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858001186 DNA binding residues [nucleotide binding] 1045858001187 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1045858001188 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858001189 Sulfatase; Region: Sulfatase; pfam00884 1045858001190 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858001191 Sulfatase; Region: Sulfatase; pfam00884 1045858001192 Sulfatase; Region: Sulfatase; cl17466 1045858001193 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1045858001194 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858001195 Sulfatase; Region: Sulfatase; pfam00884 1045858001196 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1045858001197 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1045858001198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858001199 FeS/SAM binding site; other site 1045858001200 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1045858001201 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1045858001202 putative active site pocket [active] 1045858001203 cleavage site 1045858001204 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1045858001205 classical (c) SDRs; Region: SDR_c; cd05233 1045858001206 NAD(P) binding site [chemical binding]; other site 1045858001207 active site 1045858001208 Predicted transcriptional regulators [Transcription]; Region: COG1733 1045858001209 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1045858001210 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1045858001211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858001212 Walker A motif; other site 1045858001213 ATP binding site [chemical binding]; other site 1045858001214 Walker B motif; other site 1045858001215 arginine finger; other site 1045858001216 Peptidase family M41; Region: Peptidase_M41; pfam01434 1045858001217 NlpC/P60 family; Region: NLPC_P60; cl17555 1045858001218 NlpC/P60 family; Region: NLPC_P60; cl17555 1045858001219 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1045858001220 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1045858001221 putative active site; other site 1045858001222 putative metal binding residues [ion binding]; other site 1045858001223 signature motif; other site 1045858001224 putative triphosphate binding site [ion binding]; other site 1045858001225 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1045858001226 rod shape-determining protein MreC; Provisional; Region: PRK13922 1045858001227 rod shape-determining protein MreC; Region: MreC; pfam04085 1045858001228 rod shape-determining protein MreB; Provisional; Region: PRK13927 1045858001229 MreB and similar proteins; Region: MreB_like; cd10225 1045858001230 nucleotide binding site [chemical binding]; other site 1045858001231 Mg binding site [ion binding]; other site 1045858001232 putative protofilament interaction site [polypeptide binding]; other site 1045858001233 RodZ interaction site [polypeptide binding]; other site 1045858001234 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 1045858001235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001236 binding surface 1045858001237 dimer interface [polypeptide binding]; other site 1045858001238 TPR motif; other site 1045858001239 TPR repeat; Region: TPR_11; pfam13414 1045858001240 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1045858001241 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1045858001242 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1045858001243 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1045858001244 Response regulator receiver domain; Region: Response_reg; pfam00072 1045858001245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858001246 active site 1045858001247 phosphorylation site [posttranslational modification] 1045858001248 intermolecular recognition site; other site 1045858001249 dimerization interface [polypeptide binding]; other site 1045858001250 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1045858001251 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1045858001252 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1045858001253 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045858001254 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858001255 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1045858001256 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1045858001257 Na binding site [ion binding]; other site 1045858001258 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858001259 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858001260 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858001261 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1045858001262 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045858001263 active site 1045858001264 HIGH motif; other site 1045858001265 nucleotide binding site [chemical binding]; other site 1045858001266 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1045858001267 active site 1045858001268 KMSKS motif; other site 1045858001269 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1045858001270 tRNA binding surface [nucleotide binding]; other site 1045858001271 anticodon binding site; other site 1045858001272 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1045858001273 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1045858001274 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045858001275 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1045858001276 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1045858001277 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1045858001278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858001279 Zn2+ binding site [ion binding]; other site 1045858001280 Mg2+ binding site [ion binding]; other site 1045858001281 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858001282 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1045858001283 B3/4 domain; Region: B3_4; pfam03483 1045858001284 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1045858001285 Cache domain; Region: Cache_1; pfam02743 1045858001286 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858001287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001288 dimer interface [polypeptide binding]; other site 1045858001289 putative CheW interface [polypeptide binding]; other site 1045858001290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 1045858001291 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1045858001292 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1045858001293 substrate binding pocket [chemical binding]; other site 1045858001294 chain length determination region; other site 1045858001295 substrate-Mg2+ binding site; other site 1045858001296 catalytic residues [active] 1045858001297 aspartate-rich region 1; other site 1045858001298 active site lid residues [active] 1045858001299 aspartate-rich region 2; other site 1045858001300 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858001301 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1045858001302 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1045858001303 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1045858001304 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1045858001305 potential frameshift: common BLAST hit: gi|300870599|ref|YP_003785470.1| surface antigen BspA like protein 1045858001306 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001307 Sec1 family; Region: Sec1; cl15415 1045858001308 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1045858001309 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045858001310 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1045858001311 homotrimer interaction site [polypeptide binding]; other site 1045858001312 zinc binding site [ion binding]; other site 1045858001313 CDP-binding sites; other site 1045858001314 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1045858001315 substrate binding pocket [chemical binding]; other site 1045858001316 substrate-Mg2+ binding site; other site 1045858001317 aspartate-rich region 1; other site 1045858001318 aspartate-rich region 2; other site 1045858001319 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1045858001320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858001321 S-adenosylmethionine binding site [chemical binding]; other site 1045858001322 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1045858001323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858001324 TPR motif; other site 1045858001325 binding surface 1045858001326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858001327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001328 binding surface 1045858001329 TPR motif; other site 1045858001330 TPR repeat; Region: TPR_11; pfam13414 1045858001331 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1045858001332 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1045858001333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858001334 dimerization interface [polypeptide binding]; other site 1045858001335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858001336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001337 dimer interface [polypeptide binding]; other site 1045858001338 putative CheW interface [polypeptide binding]; other site 1045858001339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858001340 dimerization interface [polypeptide binding]; other site 1045858001341 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858001342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001343 dimer interface [polypeptide binding]; other site 1045858001344 putative CheW interface [polypeptide binding]; other site 1045858001345 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1045858001346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858001347 dimerization interface [polypeptide binding]; other site 1045858001348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001349 dimer interface [polypeptide binding]; other site 1045858001350 putative CheW interface [polypeptide binding]; other site 1045858001351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001352 binding surface 1045858001353 TPR motif; other site 1045858001354 TPR repeat; Region: TPR_11; pfam13414 1045858001355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001356 binding surface 1045858001357 TPR motif; other site 1045858001358 TPR repeat; Region: TPR_11; pfam13414 1045858001359 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1045858001360 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1045858001361 dimer interface [polypeptide binding]; other site 1045858001362 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1045858001363 GAF domain; Region: GAF; cl17456 1045858001364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858001365 ATP binding site [chemical binding]; other site 1045858001366 Mg2+ binding site [ion binding]; other site 1045858001367 G-X-G motif; other site 1045858001368 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1045858001369 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1045858001370 active site 1045858001371 catalytic site [active] 1045858001372 Response regulator receiver domain; Region: Response_reg; pfam00072 1045858001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858001374 active site 1045858001375 phosphorylation site [posttranslational modification] 1045858001376 dimerization interface [polypeptide binding]; other site 1045858001377 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1045858001378 dimer interface [polypeptide binding]; other site 1045858001379 substrate binding site [chemical binding]; other site 1045858001380 ATP binding site [chemical binding]; other site 1045858001381 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1045858001382 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1045858001383 active site 1045858001384 dimer interface [polypeptide binding]; other site 1045858001385 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1045858001386 DALR anticodon binding domain; Region: DALR_1; pfam05746 1045858001387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858001388 active site 1045858001389 phosphorylation site [posttranslational modification] 1045858001390 intermolecular recognition site; other site 1045858001391 dimerization interface [polypeptide binding]; other site 1045858001392 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1045858001393 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1045858001394 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1045858001395 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1045858001396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045858001397 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045858001398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858001399 DNA binding residues [nucleotide binding] 1045858001400 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1045858001401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858001402 FeS/SAM binding site; other site 1045858001403 Trp repressor protein; Region: Trp_repressor; cl17266 1045858001404 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858001405 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858001406 DNA polymerase III subunit beta; Validated; Region: PRK05643 1045858001407 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1045858001408 putative DNA binding surface [nucleotide binding]; other site 1045858001409 dimer interface [polypeptide binding]; other site 1045858001410 beta-clamp/clamp loader binding surface; other site 1045858001411 beta-clamp/translesion DNA polymerase binding surface; other site 1045858001412 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1045858001413 putative active site [active] 1045858001414 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1045858001415 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1045858001416 cell division protein FtsA; Region: ftsA; TIGR01174 1045858001417 Cell division protein FtsA; Region: FtsA; smart00842 1045858001418 Cell division protein FtsA; Region: FtsA; pfam14450 1045858001419 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1045858001420 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045858001421 putative active site [active] 1045858001422 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1045858001423 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 1045858001424 active site 1045858001425 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 1045858001426 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1045858001427 Isochorismatase family; Region: Isochorismatase; pfam00857 1045858001428 catalytic triad [active] 1045858001429 dimer interface [polypeptide binding]; other site 1045858001430 conserved cis-peptide bond; other site 1045858001431 triosephosphate isomerase; Provisional; Region: PRK14567 1045858001432 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1045858001433 substrate binding site [chemical binding]; other site 1045858001434 dimer interface [polypeptide binding]; other site 1045858001435 catalytic triad [active] 1045858001436 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1045858001437 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1045858001438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045858001439 endonuclease III; Region: ENDO3c; smart00478 1045858001440 minor groove reading motif; other site 1045858001441 helix-hairpin-helix signature motif; other site 1045858001442 substrate binding pocket [chemical binding]; other site 1045858001443 active site 1045858001444 EamA-like transporter family; Region: EamA; pfam00892 1045858001445 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045858001446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045858001447 active site residue [active] 1045858001448 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1045858001449 anti sigma factor interaction site; other site 1045858001450 regulatory phosphorylation site [posttranslational modification]; other site 1045858001451 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1045858001452 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1045858001453 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1045858001454 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1045858001455 Helix-turn-helix domain; Region: HTH_25; pfam13413 1045858001456 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1045858001457 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1045858001458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858001459 FeS/SAM binding site; other site 1045858001460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858001461 Walker A motif; other site 1045858001462 ATP binding site [chemical binding]; other site 1045858001463 Walker B motif; other site 1045858001464 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045858001465 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1045858001466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045858001467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858001468 DNA binding residues [nucleotide binding] 1045858001469 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1045858001470 Clp amino terminal domain; Region: Clp_N; pfam02861 1045858001471 Clp amino terminal domain; Region: Clp_N; pfam02861 1045858001472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858001473 Walker A motif; other site 1045858001474 ATP binding site [chemical binding]; other site 1045858001475 Walker B motif; other site 1045858001476 arginine finger; other site 1045858001477 UvrB/uvrC motif; Region: UVR; pfam02151 1045858001478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858001479 Walker A motif; other site 1045858001480 ATP binding site [chemical binding]; other site 1045858001481 Walker B motif; other site 1045858001482 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1045858001483 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1045858001484 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1045858001485 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1045858001486 putative oxidoreductase; Provisional; Region: PRK12831 1045858001487 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045858001488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045858001489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858001490 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1045858001491 Class I aldolases; Region: Aldolase_Class_I; cl17187 1045858001492 catalytic residue [active] 1045858001493 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1045858001494 LytB protein; Region: LYTB; cl00507 1045858001495 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1045858001496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1045858001497 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1045858001498 ABC1 family; Region: ABC1; cl17513 1045858001499 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1045858001500 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1045858001501 DNA methylase; Region: N6_N4_Mtase; cl17433 1045858001502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858001503 S-adenosylmethionine binding site [chemical binding]; other site 1045858001504 DNA methylase; Region: N6_N4_Mtase; cl17433 1045858001505 TPR repeat; Region: TPR_11; pfam13414 1045858001506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001507 binding surface 1045858001508 TPR motif; other site 1045858001509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001510 binding surface 1045858001511 TPR motif; other site 1045858001512 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858001513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001514 binding surface 1045858001515 TPR repeat; Region: TPR_11; pfam13414 1045858001516 TPR motif; other site 1045858001517 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 1045858001518 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1045858001519 gamma subunit interface [polypeptide binding]; other site 1045858001520 epsilon subunit interface [polypeptide binding]; other site 1045858001521 LBP interface [polypeptide binding]; other site 1045858001522 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045858001523 active site 1045858001524 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1045858001525 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1045858001526 active site 1045858001527 (T/H)XGH motif; other site 1045858001528 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1045858001529 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1045858001530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858001531 FeS/SAM binding site; other site 1045858001532 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1045858001533 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1045858001534 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1045858001535 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1045858001536 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858001537 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858001538 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858001539 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858001540 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 1045858001541 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1045858001542 putative FMN binding site [chemical binding]; other site 1045858001543 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1045858001544 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1045858001545 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1045858001546 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1045858001547 Na2 binding site [ion binding]; other site 1045858001548 putative substrate binding site 1 [chemical binding]; other site 1045858001549 Na binding site 1 [ion binding]; other site 1045858001550 putative substrate binding site 2 [chemical binding]; other site 1045858001551 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045858001552 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1045858001553 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1045858001554 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045858001555 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045858001556 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 1045858001557 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1045858001558 dimerization interface [polypeptide binding]; other site 1045858001559 putative ATP binding site [chemical binding]; other site 1045858001560 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858001561 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858001562 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1045858001563 active site 1045858001564 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1045858001565 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858001566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858001567 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1045858001568 NAD(P) binding site [chemical binding]; other site 1045858001569 active site 1045858001570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858001571 dimer interface [polypeptide binding]; other site 1045858001572 conserved gate region; other site 1045858001573 putative PBP binding loops; other site 1045858001574 ABC-ATPase subunit interface; other site 1045858001575 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1045858001576 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1045858001577 Walker A/P-loop; other site 1045858001578 ATP binding site [chemical binding]; other site 1045858001579 Q-loop/lid; other site 1045858001580 ABC transporter signature motif; other site 1045858001581 Walker B; other site 1045858001582 D-loop; other site 1045858001583 H-loop/switch region; other site 1045858001584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858001585 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045858001586 substrate binding pocket [chemical binding]; other site 1045858001587 membrane-bound complex binding site; other site 1045858001588 hinge residues; other site 1045858001589 Leucine rich repeat; Region: LRR_8; pfam13855 1045858001590 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1045858001591 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1045858001592 active site 1045858001593 catalytic residue [active] 1045858001594 dimer interface [polypeptide binding]; other site 1045858001595 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1045858001596 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1045858001597 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1045858001598 shikimate binding site; other site 1045858001599 NAD(P) binding site [chemical binding]; other site 1045858001600 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1045858001601 homotrimer interaction site [polypeptide binding]; other site 1045858001602 putative active site [active] 1045858001603 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1045858001604 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1045858001605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001606 TPR motif; other site 1045858001607 binding surface 1045858001608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858001609 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1045858001610 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 1045858001611 6-phosphofructokinase; Provisional; Region: PRK03202 1045858001612 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1045858001613 active site 1045858001614 ADP/pyrophosphate binding site [chemical binding]; other site 1045858001615 dimerization interface [polypeptide binding]; other site 1045858001616 allosteric effector site; other site 1045858001617 fructose-1,6-bisphosphate binding site; other site 1045858001618 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1045858001619 MgtE intracellular N domain; Region: MgtE_N; smart00924 1045858001620 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1045858001621 Divalent cation transporter; Region: MgtE; pfam01769 1045858001622 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1045858001623 Na2 binding site [ion binding]; other site 1045858001624 putative substrate binding site 1 [chemical binding]; other site 1045858001625 Na binding site 1 [ion binding]; other site 1045858001626 putative substrate binding site 2 [chemical binding]; other site 1045858001627 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1045858001628 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1045858001629 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1045858001630 Predicted transcriptional regulator [Transcription]; Region: COG1959 1045858001631 Transcriptional regulator; Region: Rrf2; pfam02082 1045858001632 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858001633 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858001634 ligand binding site [chemical binding]; other site 1045858001635 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1045858001636 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1045858001637 Na binding site [ion binding]; other site 1045858001638 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 1045858001639 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1045858001640 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1045858001641 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1045858001642 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045858001643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858001644 catalytic residue [active] 1045858001645 SirA-like protein; Region: SirA; pfam01206 1045858001646 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1045858001647 CPxP motif; other site 1045858001648 DsrE/DsrF-like family; Region: DrsE; cl00672 1045858001649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858001650 dimer interface [polypeptide binding]; other site 1045858001651 putative CheW interface [polypeptide binding]; other site 1045858001652 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1045858001653 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858001654 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1045858001655 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045858001656 Catalytic site [active] 1045858001657 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1045858001658 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045858001659 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1045858001660 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 1045858001661 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1045858001662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045858001663 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1045858001664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045858001665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045858001666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045858001667 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1045858001668 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1045858001669 active site 1045858001670 dimer interface [polypeptide binding]; other site 1045858001671 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1045858001672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858001673 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045858001674 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1045858001675 Phosphotransferase enzyme family; Region: APH; pfam01636 1045858001676 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1045858001677 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1045858001678 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1045858001679 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1045858001680 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1045858001681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858001682 active site 1045858001683 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1045858001684 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1045858001685 5S rRNA interface [nucleotide binding]; other site 1045858001686 CTC domain interface [polypeptide binding]; other site 1045858001687 L16 interface [polypeptide binding]; other site 1045858001688 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1045858001689 putative active site [active] 1045858001690 catalytic residue [active] 1045858001691 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1045858001692 putative active site [active] 1045858001693 catalytic residue [active] 1045858001694 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1045858001695 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1045858001696 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1045858001697 Domain of unknown function (DUF386); Region: DUF386; cl01047 1045858001698 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1045858001699 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045858001700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045858001701 catalytic loop [active] 1045858001702 iron binding site [ion binding]; other site 1045858001703 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1045858001704 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1045858001705 4Fe-4S binding domain; Region: Fer4; pfam00037 1045858001706 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1045858001707 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1045858001708 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1045858001709 dimer interface [polypeptide binding]; other site 1045858001710 [2Fe-2S] cluster binding site [ion binding]; other site 1045858001711 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1045858001712 SLBB domain; Region: SLBB; pfam10531 1045858001713 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1045858001714 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1045858001715 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1045858001716 putative dimer interface [polypeptide binding]; other site 1045858001717 [2Fe-2S] cluster binding site [ion binding]; other site 1045858001718 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 1045858001719 Predicted ATPases [General function prediction only]; Region: COG1106 1045858001720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858001721 Walker A/P-loop; other site 1045858001722 ATP binding site [chemical binding]; other site 1045858001723 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1045858001724 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1045858001725 purine monophosphate binding site [chemical binding]; other site 1045858001726 dimer interface [polypeptide binding]; other site 1045858001727 putative catalytic residues [active] 1045858001728 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1045858001729 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1045858001730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045858001731 active site residue [active] 1045858001732 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1045858001733 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858001734 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858001735 peptide binding site [polypeptide binding]; other site 1045858001736 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1045858001737 methionine cluster; other site 1045858001738 active site 1045858001739 phosphorylation site [posttranslational modification] 1045858001740 metal binding site [ion binding]; metal-binding site 1045858001741 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1045858001742 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1045858001743 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1045858001744 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1045858001745 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1045858001746 active site 1045858001747 P-loop; other site 1045858001748 phosphorylation site [posttranslational modification] 1045858001749 HTH domain; Region: HTH_11; pfam08279 1045858001750 Mga helix-turn-helix domain; Region: Mga; pfam05043 1045858001751 PRD domain; Region: PRD; pfam00874 1045858001752 PRD domain; Region: PRD; pfam00874 1045858001753 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1045858001754 active site 1045858001755 P-loop; other site 1045858001756 phosphorylation site [posttranslational modification] 1045858001757 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858001758 active site 1045858001759 phosphorylation site [posttranslational modification] 1045858001760 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045858001761 dimerization domain swap beta strand [polypeptide binding]; other site 1045858001762 regulatory protein interface [polypeptide binding]; other site 1045858001763 active site 1045858001764 regulatory phosphorylation site [posttranslational modification]; other site 1045858001765 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1045858001766 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045858001767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858001768 S-adenosylmethionine binding site [chemical binding]; other site 1045858001769 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045858001770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045858001771 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1045858001772 catalytic triad [active] 1045858001773 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001774 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001775 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001776 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001777 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001778 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858001779 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1045858001780 active site 1045858001781 substrate binding site [chemical binding]; other site 1045858001782 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1045858001783 FMN binding site [chemical binding]; other site 1045858001784 putative catalytic residues [active] 1045858001785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001786 TPR motif; other site 1045858001787 binding surface 1045858001788 TPR repeat; Region: TPR_11; pfam13414 1045858001789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001790 binding surface 1045858001791 TPR repeat; Region: TPR_11; pfam13414 1045858001792 TPR motif; other site 1045858001793 TPR repeat; Region: TPR_11; pfam13414 1045858001794 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1045858001795 TPR repeat; Region: TPR_11; pfam13414 1045858001796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001797 binding surface 1045858001798 TPR motif; other site 1045858001799 TPR repeat; Region: TPR_11; pfam13414 1045858001800 TPR repeat; Region: TPR_11; pfam13414 1045858001801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001802 binding surface 1045858001803 TPR motif; other site 1045858001804 TPR repeat; Region: TPR_11; pfam13414 1045858001805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001806 binding surface 1045858001807 TPR repeat; Region: TPR_11; pfam13414 1045858001808 TPR motif; other site 1045858001809 TPR repeat; Region: TPR_11; pfam13414 1045858001810 TPR repeat; Region: TPR_11; pfam13414 1045858001811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001812 binding surface 1045858001813 TPR motif; other site 1045858001814 TPR repeat; Region: TPR_11; pfam13414 1045858001815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001816 binding surface 1045858001817 TPR motif; other site 1045858001818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001819 binding surface 1045858001820 TPR repeat; Region: TPR_11; pfam13414 1045858001821 TPR motif; other site 1045858001822 TPR repeat; Region: TPR_11; pfam13414 1045858001823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001824 TPR motif; other site 1045858001825 binding surface 1045858001826 TPR repeat; Region: TPR_11; pfam13414 1045858001827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001828 binding surface 1045858001829 TPR motif; other site 1045858001830 TPR repeat; Region: TPR_11; pfam13414 1045858001831 TPR repeat; Region: TPR_11; pfam13414 1045858001832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001833 binding surface 1045858001834 TPR motif; other site 1045858001835 TPR repeat; Region: TPR_11; pfam13414 1045858001836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001837 binding surface 1045858001838 TPR motif; other site 1045858001839 TPR repeat; Region: TPR_11; pfam13414 1045858001840 TPR repeat; Region: TPR_11; pfam13414 1045858001841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001842 binding surface 1045858001843 TPR motif; other site 1045858001844 TPR repeat; Region: TPR_11; pfam13414 1045858001845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001846 binding surface 1045858001847 TPR motif; other site 1045858001848 TPR repeat; Region: TPR_11; pfam13414 1045858001849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001850 binding surface 1045858001851 TPR motif; other site 1045858001852 TPR repeat; Region: TPR_11; pfam13414 1045858001853 TPR repeat; Region: TPR_11; pfam13414 1045858001854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001855 binding surface 1045858001856 TPR motif; other site 1045858001857 TPR repeat; Region: TPR_11; pfam13414 1045858001858 TPR repeat; Region: TPR_11; pfam13414 1045858001859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858001860 binding surface 1045858001861 TPR motif; other site 1045858001862 TPR repeat; Region: TPR_11; pfam13414 1045858001863 magnesium-transporting ATPase; Provisional; Region: PRK15122 1045858001864 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1045858001865 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045858001866 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1045858001867 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045858001868 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1045858001869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1045858001870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858001871 dimer interface [polypeptide binding]; other site 1045858001872 conserved gate region; other site 1045858001873 putative PBP binding loops; other site 1045858001874 ABC-ATPase subunit interface; other site 1045858001875 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1045858001876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1045858001877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858001878 dimer interface [polypeptide binding]; other site 1045858001879 conserved gate region; other site 1045858001880 putative PBP binding loops; other site 1045858001881 ABC-ATPase subunit interface; other site 1045858001882 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1045858001883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045858001884 Walker A/P-loop; other site 1045858001885 ATP binding site [chemical binding]; other site 1045858001886 Q-loop/lid; other site 1045858001887 ABC transporter signature motif; other site 1045858001888 Walker B; other site 1045858001889 D-loop; other site 1045858001890 H-loop/switch region; other site 1045858001891 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045858001892 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1045858001893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045858001894 Walker A/P-loop; other site 1045858001895 ATP binding site [chemical binding]; other site 1045858001896 Q-loop/lid; other site 1045858001897 ABC transporter signature motif; other site 1045858001898 Walker B; other site 1045858001899 D-loop; other site 1045858001900 H-loop/switch region; other site 1045858001901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1045858001902 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858001903 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858001904 peptide binding site [polypeptide binding]; other site 1045858001905 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1045858001906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858001907 active site 1045858001908 motif I; other site 1045858001909 motif II; other site 1045858001910 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1045858001911 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045858001912 putative binding surface; other site 1045858001913 active site 1045858001914 P2 response regulator binding domain; Region: P2; pfam07194 1045858001915 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1045858001916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858001917 ATP binding site [chemical binding]; other site 1045858001918 Mg2+ binding site [ion binding]; other site 1045858001919 G-X-G motif; other site 1045858001920 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1045858001921 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1045858001922 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1045858001923 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1045858001924 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1045858001925 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1045858001926 active site 1045858001927 metal binding site [ion binding]; metal-binding site 1045858001928 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045858001929 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1045858001930 META domain; Region: META; pfam03724 1045858001931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045858001932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045858001933 TM-ABC transporter signature motif; other site 1045858001934 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045858001935 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1045858001936 Walker A/P-loop; other site 1045858001937 ATP binding site [chemical binding]; other site 1045858001938 Q-loop/lid; other site 1045858001939 ABC transporter signature motif; other site 1045858001940 Walker B; other site 1045858001941 D-loop; other site 1045858001942 H-loop/switch region; other site 1045858001943 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045858001944 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1045858001945 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045858001946 ligand binding site [chemical binding]; other site 1045858001947 calcium binding site [ion binding]; other site 1045858001948 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1045858001949 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1045858001950 ligand binding site [chemical binding]; other site 1045858001951 calcium binding site [ion binding]; other site 1045858001952 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1045858001953 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045858001954 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1045858001955 active site 1045858001956 dimer interface [polypeptide binding]; other site 1045858001957 metal binding site [ion binding]; metal-binding site 1045858001958 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858001959 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 1045858001960 Membrane transport protein; Region: Mem_trans; cl09117 1045858001961 heat shock protein 90; Provisional; Region: PRK05218 1045858001962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858001963 ATP binding site [chemical binding]; other site 1045858001964 Mg2+ binding site [ion binding]; other site 1045858001965 G-X-G motif; other site 1045858001966 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858001967 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045858001968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858001969 DNA binding residues [nucleotide binding] 1045858001970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045858001971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858001972 Coenzyme A binding pocket [chemical binding]; other site 1045858001973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858001974 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045858001975 substrate binding pocket [chemical binding]; other site 1045858001976 membrane-bound complex binding site; other site 1045858001977 hinge residues; other site 1045858001978 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1045858001979 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1045858001980 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1045858001981 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1045858001982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858001983 dimer interface [polypeptide binding]; other site 1045858001984 conserved gate region; other site 1045858001985 putative PBP binding loops; other site 1045858001986 ABC-ATPase subunit interface; other site 1045858001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858001988 dimer interface [polypeptide binding]; other site 1045858001989 conserved gate region; other site 1045858001990 putative PBP binding loops; other site 1045858001991 ABC-ATPase subunit interface; other site 1045858001992 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045858001993 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045858001994 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1045858001995 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045858001996 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045858001997 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045858001998 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 1045858001999 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1045858002000 DNA methylase; Region: N6_N4_Mtase; pfam01555 1045858002001 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1045858002002 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1045858002003 DNA methylase; Region: N6_N4_Mtase; cl17433 1045858002004 GMP synthase; Reviewed; Region: guaA; PRK00074 1045858002005 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1045858002006 AMP/PPi binding site [chemical binding]; other site 1045858002007 candidate oxyanion hole; other site 1045858002008 catalytic triad [active] 1045858002009 potential glutamine specificity residues [chemical binding]; other site 1045858002010 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1045858002011 ATP Binding subdomain [chemical binding]; other site 1045858002012 Ligand Binding sites [chemical binding]; other site 1045858002013 Dimerization subdomain; other site 1045858002014 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1045858002015 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1045858002016 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858002017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858002018 dimer interface [polypeptide binding]; other site 1045858002019 putative CheW interface [polypeptide binding]; other site 1045858002020 Rod binding protein; Region: Rod-binding; pfam10135 1045858002021 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1045858002022 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045858002023 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1045858002024 DNA polymerase I; Provisional; Region: PRK05755 1045858002025 active site 1045858002026 putative 5' ssDNA interaction site; other site 1045858002027 metal binding site 3; metal-binding site 1045858002028 metal binding site 1 [ion binding]; metal-binding site 1045858002029 metal binding site 2 [ion binding]; metal-binding site 1045858002030 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1045858002031 putative DNA binding site [nucleotide binding]; other site 1045858002032 putative metal binding site [ion binding]; other site 1045858002033 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1045858002034 active site 1045858002035 catalytic site [active] 1045858002036 substrate binding site [chemical binding]; other site 1045858002037 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1045858002038 active site 1045858002039 DNA binding site [nucleotide binding] 1045858002040 catalytic site [active] 1045858002041 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1045858002042 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1045858002043 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1045858002044 active site 1045858002045 metal binding site [ion binding]; metal-binding site 1045858002046 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1045858002047 DNA topoisomerase I; Validated; Region: PRK05582 1045858002048 active site 1045858002049 metal binding site [ion binding]; metal-binding site 1045858002050 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1045858002051 domain I; other site 1045858002052 DNA binding groove [nucleotide binding] 1045858002053 phosphate binding site [ion binding]; other site 1045858002054 domain II; other site 1045858002055 domain III; other site 1045858002056 nucleotide binding site [chemical binding]; other site 1045858002057 catalytic site [active] 1045858002058 domain IV; other site 1045858002059 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045858002060 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1045858002061 DNA protecting protein DprA; Region: dprA; TIGR00732 1045858002062 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1045858002063 TPR repeat; Region: TPR_11; pfam13414 1045858002064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002065 binding surface 1045858002066 TPR motif; other site 1045858002067 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1045858002068 Part of AAA domain; Region: AAA_19; pfam13245 1045858002069 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1045858002070 Family description; Region: UvrD_C_2; pfam13538 1045858002071 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1045858002072 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1045858002073 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1045858002074 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045858002075 putative active site [active] 1045858002076 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1045858002077 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1045858002078 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 1045858002079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045858002080 non-specific DNA binding site [nucleotide binding]; other site 1045858002081 salt bridge; other site 1045858002082 sequence-specific DNA binding site [nucleotide binding]; other site 1045858002083 Putative motility protein; Region: YjfB_motility; pfam14070 1045858002084 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1045858002085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045858002086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858002087 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045858002088 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1045858002089 active site residue [active] 1045858002090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045858002091 active site residue [active] 1045858002092 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1045858002093 putative homotetramer interface [polypeptide binding]; other site 1045858002094 putative homodimer interface [polypeptide binding]; other site 1045858002095 putative allosteric switch controlling residues; other site 1045858002096 putative metal binding site [ion binding]; other site 1045858002097 putative homodimer-homodimer interface [polypeptide binding]; other site 1045858002098 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1045858002099 active site 1045858002100 dimer interface [polypeptide binding]; other site 1045858002101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858002102 active site 1045858002103 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1045858002104 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1045858002105 heterodimer interface [polypeptide binding]; other site 1045858002106 active site 1045858002107 FMN binding site [chemical binding]; other site 1045858002108 homodimer interface [polypeptide binding]; other site 1045858002109 substrate binding site [chemical binding]; other site 1045858002110 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1045858002111 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1045858002112 FAD binding pocket [chemical binding]; other site 1045858002113 FAD binding motif [chemical binding]; other site 1045858002114 phosphate binding motif [ion binding]; other site 1045858002115 beta-alpha-beta structure motif; other site 1045858002116 NAD binding pocket [chemical binding]; other site 1045858002117 Iron coordination center [ion binding]; other site 1045858002118 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858002119 4Fe-4S binding domain; Region: Fer4; pfam00037 1045858002120 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1045858002121 Aerotolerance regulator N-terminal; Region: BatA; cl06567 1045858002122 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1045858002123 metal ion-dependent adhesion site (MIDAS); other site 1045858002124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858002125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002126 TPR motif; other site 1045858002127 binding surface 1045858002128 Oxygen tolerance; Region: BatD; pfam13584 1045858002129 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858002130 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1045858002131 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1045858002132 Ligand Binding Site [chemical binding]; other site 1045858002133 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1045858002134 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 1045858002135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858002136 binding surface 1045858002137 TPR motif; other site 1045858002138 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045858002139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045858002140 active site 1045858002141 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1045858002142 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1045858002143 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1045858002144 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1045858002145 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1045858002146 active site 1045858002147 metal binding site [ion binding]; metal-binding site 1045858002148 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045858002149 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1045858002150 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1045858002151 active site 1045858002152 putative substrate binding pocket [chemical binding]; other site 1045858002153 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1045858002154 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1045858002155 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1045858002156 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045858002157 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1045858002158 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1045858002159 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1045858002160 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858002161 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858002162 active site 1045858002163 catalytic tetrad [active] 1045858002164 Flagellar protein FliS; Region: FliS; cl00654 1045858002165 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 1045858002166 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1045858002167 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1045858002168 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1045858002169 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1045858002170 active site 1045858002171 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1045858002172 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1045858002173 active site 1045858002174 dimer interface [polypeptide binding]; other site 1045858002175 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1045858002176 active site 1045858002177 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1045858002178 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1045858002179 putative substrate binding site [chemical binding]; other site 1045858002180 putative ATP binding site [chemical binding]; other site 1045858002181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045858002182 catalytic residues [active] 1045858002183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045858002184 MarR family; Region: MarR_2; pfam12802 1045858002185 Predicted membrane protein [Function unknown]; Region: COG2364 1045858002186 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1045858002187 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1045858002188 dimer interface [polypeptide binding]; other site 1045858002189 active site 1045858002190 acyl carrier protein; Provisional; Region: acpP; PRK00982 1045858002191 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1045858002192 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1045858002193 NAD(P) binding site [chemical binding]; other site 1045858002194 homotetramer interface [polypeptide binding]; other site 1045858002195 homodimer interface [polypeptide binding]; other site 1045858002196 active site 1045858002197 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1045858002198 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1045858002199 active site 1045858002200 substrate binding site [chemical binding]; other site 1045858002201 metal binding site [ion binding]; metal-binding site 1045858002202 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858002203 ligand binding site [chemical binding]; other site 1045858002204 flexible hinge region; other site 1045858002205 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858002206 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1045858002207 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1045858002208 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1045858002209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858002210 binding surface 1045858002211 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858002212 TPR motif; other site 1045858002213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002214 binding surface 1045858002215 TPR motif; other site 1045858002216 TPR repeat; Region: TPR_11; pfam13414 1045858002217 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1045858002218 galactokinase; Provisional; Region: PRK05322 1045858002219 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1045858002220 peptide chain release factor 2; Provisional; Region: PRK05589 1045858002221 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1045858002222 RF-1 domain; Region: RF-1; pfam00472 1045858002223 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1045858002224 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1045858002225 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1045858002226 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1045858002227 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045858002228 Walker A/P-loop; other site 1045858002229 ATP binding site [chemical binding]; other site 1045858002230 Q-loop/lid; other site 1045858002231 ABC transporter signature motif; other site 1045858002232 Walker B; other site 1045858002233 D-loop; other site 1045858002234 H-loop/switch region; other site 1045858002235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858002236 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045858002237 Walker A motif; other site 1045858002238 ATP binding site [chemical binding]; other site 1045858002239 Walker B motif; other site 1045858002240 arginine finger; other site 1045858002241 hypothetical protein; Provisional; Region: yieM; PRK10997 1045858002242 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1045858002243 metal ion-dependent adhesion site (MIDAS); other site 1045858002244 ribonuclease III; Reviewed; Region: rnc; PRK00102 1045858002245 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1045858002246 dimerization interface [polypeptide binding]; other site 1045858002247 active site 1045858002248 metal binding site [ion binding]; metal-binding site 1045858002249 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1045858002250 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1045858002251 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1045858002252 substrate binding site [chemical binding]; other site 1045858002253 hexamer interface [polypeptide binding]; other site 1045858002254 metal binding site [ion binding]; metal-binding site 1045858002255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002256 binding surface 1045858002257 TPR repeat; Region: TPR_11; pfam13414 1045858002258 TPR motif; other site 1045858002259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002260 binding surface 1045858002261 TPR motif; other site 1045858002262 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1045858002263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002264 TPR motif; other site 1045858002265 binding surface 1045858002266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002267 binding surface 1045858002268 TPR motif; other site 1045858002269 rarD protein; Region: rarD; TIGR00688 1045858002270 TPR repeat; Region: TPR_11; pfam13414 1045858002271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858002272 binding surface 1045858002273 TPR motif; other site 1045858002274 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1045858002275 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1045858002276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858002277 S-adenosylmethionine binding site [chemical binding]; other site 1045858002278 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1045858002279 pyruvate kinase; Provisional; Region: PRK05826 1045858002280 domain interfaces; other site 1045858002281 active site 1045858002282 DNA repair protein RadA; Provisional; Region: PRK11823 1045858002283 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045858002284 Walker A motif; other site 1045858002285 ATP binding site [chemical binding]; other site 1045858002286 Walker B motif; other site 1045858002287 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1045858002288 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1045858002289 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 1045858002290 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045858002291 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045858002292 active site 1045858002293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002294 binding surface 1045858002295 TPR motif; other site 1045858002296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002297 TPR motif; other site 1045858002298 binding surface 1045858002299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002300 TPR motif; other site 1045858002301 binding surface 1045858002302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002303 binding surface 1045858002304 TPR motif; other site 1045858002305 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1045858002306 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1045858002307 putative RNA binding site [nucleotide binding]; other site 1045858002308 adenylate kinase; Reviewed; Region: adk; PRK00279 1045858002309 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1045858002310 AMP-binding site [chemical binding]; other site 1045858002311 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1045858002312 PEGA domain; Region: PEGA; pfam08308 1045858002313 aspartate aminotransferase; Provisional; Region: PRK07568 1045858002314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858002315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858002316 homodimer interface [polypeptide binding]; other site 1045858002317 catalytic residue [active] 1045858002318 aspartate aminotransferase; Provisional; Region: PRK07568 1045858002319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858002320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858002321 homodimer interface [polypeptide binding]; other site 1045858002322 catalytic residue [active] 1045858002323 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1045858002324 Phosphotransferase enzyme family; Region: APH; pfam01636 1045858002325 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1045858002326 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1045858002327 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1045858002328 anti sigma factor interaction site; other site 1045858002329 regulatory phosphorylation site [posttranslational modification]; other site 1045858002330 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045858002331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045858002332 non-specific DNA binding site [nucleotide binding]; other site 1045858002333 salt bridge; other site 1045858002334 sequence-specific DNA binding site [nucleotide binding]; other site 1045858002335 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1045858002336 G1 box; other site 1045858002337 GTP/Mg2+ binding site [chemical binding]; other site 1045858002338 Switch I region; other site 1045858002339 G3 box; other site 1045858002340 Switch II region; other site 1045858002341 G4 box; other site 1045858002342 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045858002343 regulatory protein interface [polypeptide binding]; other site 1045858002344 regulatory phosphorylation site [posttranslational modification]; other site 1045858002345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045858002346 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1045858002347 active site 1045858002348 metal binding site [ion binding]; metal-binding site 1045858002349 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1045858002350 NodB motif; other site 1045858002351 putative active site [active] 1045858002352 putative catalytic site [active] 1045858002353 Zn binding site [ion binding]; other site 1045858002354 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1045858002355 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1045858002356 active site 1045858002357 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045858002358 substrate binding site [chemical binding]; other site 1045858002359 catalytic residues [active] 1045858002360 dimer interface [polypeptide binding]; other site 1045858002361 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1045858002362 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1045858002363 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1045858002364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045858002365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858002366 active site 1045858002367 phosphorylation site [posttranslational modification] 1045858002368 intermolecular recognition site; other site 1045858002369 dimerization interface [polypeptide binding]; other site 1045858002370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1045858002371 DNA binding site [nucleotide binding] 1045858002372 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1045858002373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045858002374 dimer interface [polypeptide binding]; other site 1045858002375 phosphorylation site [posttranslational modification] 1045858002376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858002377 ATP binding site [chemical binding]; other site 1045858002378 Mg2+ binding site [ion binding]; other site 1045858002379 G-X-G motif; other site 1045858002380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045858002381 metal-binding site [ion binding] 1045858002382 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1045858002383 RuvA N terminal domain; Region: RuvA_N; pfam01330 1045858002384 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1045858002385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045858002386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858002387 Coenzyme A binding pocket [chemical binding]; other site 1045858002388 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045858002389 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045858002390 ScpA/B protein; Region: ScpA_ScpB; cl00598 1045858002391 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858002392 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858002393 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1045858002394 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858002395 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858002396 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858002397 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1045858002398 FAD binding domain; Region: FAD_binding_4; pfam01565 1045858002399 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1045858002400 Predicted membrane protein [Function unknown]; Region: COG2364 1045858002401 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858002402 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858002403 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858002404 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1045858002405 Bacterial Ig-like domain; Region: Big_5; pfam13205 1045858002406 Bacterial Ig-like domain; Region: Big_5; pfam13205 1045858002407 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1045858002408 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1045858002409 MG2 domain; Region: A2M_N; pfam01835 1045858002410 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1045858002411 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1045858002412 surface patch; other site 1045858002413 thioester region; other site 1045858002414 specificity defining residues; other site 1045858002415 ferrochelatase; Reviewed; Region: hemH; PRK00035 1045858002416 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1045858002417 C-terminal domain interface [polypeptide binding]; other site 1045858002418 active site 1045858002419 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1045858002420 active site 1045858002421 N-terminal domain interface [polypeptide binding]; other site 1045858002422 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1045858002423 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1045858002424 tetramer interface [polypeptide binding]; other site 1045858002425 heme binding pocket [chemical binding]; other site 1045858002426 NADPH binding site [chemical binding]; other site 1045858002427 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1045858002428 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1045858002429 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1045858002430 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1045858002431 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045858002432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045858002433 catalytic residue [active] 1045858002434 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 1045858002435 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045858002436 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045858002437 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1045858002438 MoxR-like ATPases [General function prediction only]; Region: COG0714 1045858002439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858002440 Walker A motif; other site 1045858002441 ATP binding site [chemical binding]; other site 1045858002442 Walker B motif; other site 1045858002443 arginine finger; other site 1045858002444 Oxygen tolerance; Region: BatD; pfam13584 1045858002445 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858002446 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858002447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045858002448 classical (c) SDRs; Region: SDR_c; cd05233 1045858002449 NAD(P) binding site [chemical binding]; other site 1045858002450 active site 1045858002451 potential frameshift: common BLAST hit: gi|296125715|ref|YP_003632967.1| septum formation initiator 1045858002452 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1045858002453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1045858002454 recombination protein RecR; Reviewed; Region: recR; PRK00076 1045858002455 RecR protein; Region: RecR; pfam02132 1045858002456 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1045858002457 putative active site [active] 1045858002458 putative metal-binding site [ion binding]; other site 1045858002459 tetramer interface [polypeptide binding]; other site 1045858002460 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1045858002461 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045858002462 substrate binding site [chemical binding]; other site 1045858002463 ATP binding site [chemical binding]; other site 1045858002464 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1045858002465 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1045858002466 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045858002467 CTP synthetase; Validated; Region: pyrG; PRK05380 1045858002468 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1045858002469 Catalytic site [active] 1045858002470 active site 1045858002471 UTP binding site [chemical binding]; other site 1045858002472 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1045858002473 active site 1045858002474 putative oxyanion hole; other site 1045858002475 catalytic triad [active] 1045858002476 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1045858002477 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1045858002478 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045858002479 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1045858002480 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045858002481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858002482 Walker A/P-loop; other site 1045858002483 ATP binding site [chemical binding]; other site 1045858002484 Q-loop/lid; other site 1045858002485 ABC transporter signature motif; other site 1045858002486 Walker B; other site 1045858002487 D-loop; other site 1045858002488 H-loop/switch region; other site 1045858002489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858002490 dimer interface [polypeptide binding]; other site 1045858002491 conserved gate region; other site 1045858002492 putative PBP binding loops; other site 1045858002493 ABC-ATPase subunit interface; other site 1045858002494 META domain; Region: META; cl01245 1045858002495 META domain; Region: META; pfam03724 1045858002496 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1045858002497 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1045858002498 intersubunit interface [polypeptide binding]; other site 1045858002499 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1045858002500 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1045858002501 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1045858002502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045858002503 ABC-ATPase subunit interface; other site 1045858002504 dimer interface [polypeptide binding]; other site 1045858002505 putative PBP binding regions; other site 1045858002506 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1045858002507 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045858002508 inhibitor-cofactor binding pocket; inhibition site 1045858002509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858002510 catalytic residue [active] 1045858002511 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1045858002512 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045858002513 zinc binding site [ion binding]; other site 1045858002514 putative ligand binding site [chemical binding]; other site 1045858002515 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1045858002516 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1045858002517 dimerization interface 3.5A [polypeptide binding]; other site 1045858002518 active site 1045858002519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858002520 active site 1045858002521 motif I; other site 1045858002522 motif II; other site 1045858002523 OstA-like protein; Region: OstA; cl00844 1045858002524 OstA-like protein; Region: OstA; cl00844 1045858002525 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1045858002526 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1045858002527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1045858002528 nucleotide binding region [chemical binding]; other site 1045858002529 SEC-C motif; Region: SEC-C; pfam02810 1045858002530 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1045858002531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858002532 dimer interface [polypeptide binding]; other site 1045858002533 conserved gate region; other site 1045858002534 putative PBP binding loops; other site 1045858002535 ABC-ATPase subunit interface; other site 1045858002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858002537 dimer interface [polypeptide binding]; other site 1045858002538 conserved gate region; other site 1045858002539 putative PBP binding loops; other site 1045858002540 ABC-ATPase subunit interface; other site 1045858002541 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1045858002542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858002543 Walker A/P-loop; other site 1045858002544 ATP binding site [chemical binding]; other site 1045858002545 Q-loop/lid; other site 1045858002546 ABC transporter signature motif; other site 1045858002547 Walker B; other site 1045858002548 D-loop; other site 1045858002549 H-loop/switch region; other site 1045858002550 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045858002551 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045858002552 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045858002553 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045858002554 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1045858002555 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1045858002556 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045858002557 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1045858002558 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1045858002559 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1045858002560 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1045858002561 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1045858002562 G1 box; other site 1045858002563 G1 box; other site 1045858002564 GTP/Mg2+ binding site [chemical binding]; other site 1045858002565 GTP/Mg2+ binding site [chemical binding]; other site 1045858002566 Switch I region; other site 1045858002567 G2 box; other site 1045858002568 G3 box; other site 1045858002569 Switch II region; other site 1045858002570 G4 box; other site 1045858002571 G5 box; other site 1045858002572 Nucleoside recognition; Region: Gate; pfam07670 1045858002573 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1045858002574 Nucleoside recognition; Region: Gate; pfam07670 1045858002575 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1045858002576 MPN+ (JAMM) motif; other site 1045858002577 Zinc-binding site [ion binding]; other site 1045858002578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045858002579 non-specific DNA binding site [nucleotide binding]; other site 1045858002580 salt bridge; other site 1045858002581 sequence-specific DNA binding site [nucleotide binding]; other site 1045858002582 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1045858002583 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1045858002584 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002585 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858002586 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002587 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002588 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002589 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002590 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858002591 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1045858002592 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002593 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002594 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002595 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002596 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002597 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002598 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002599 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1045858002600 potassium/proton antiporter; Reviewed; Region: PRK05326 1045858002601 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1045858002602 TrkA-C domain; Region: TrkA_C; pfam02080 1045858002603 TrkA-C domain; Region: TrkA_C; pfam02080 1045858002604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045858002605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045858002606 metal binding site [ion binding]; metal-binding site 1045858002607 active site 1045858002608 I-site; other site 1045858002609 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045858002610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858002611 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858002612 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045858002613 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1045858002614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858002615 motif II; other site 1045858002616 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1045858002617 active site 1045858002618 catalytic residues [active] 1045858002619 metal binding site [ion binding]; metal-binding site 1045858002620 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1045858002621 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1045858002622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002623 binding surface 1045858002624 TPR motif; other site 1045858002625 TPR repeat; Region: TPR_11; pfam13414 1045858002626 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1045858002627 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 1045858002628 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1045858002629 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045858002630 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045858002631 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1045858002632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1045858002633 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1045858002634 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1045858002635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858002636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858002637 active site 1045858002638 catalytic tetrad [active] 1045858002639 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1045858002640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858002641 active site 1045858002642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858002643 active site 1045858002644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858002645 active site 1045858002646 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1045858002647 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1045858002648 dimer interface [polypeptide binding]; other site 1045858002649 active site 1045858002650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858002651 active site 1045858002652 cytidylate kinase; Provisional; Region: cmk; PRK00023 1045858002653 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1045858002654 CMP-binding site; other site 1045858002655 The sites determining sugar specificity; other site 1045858002656 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1045858002657 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1045858002658 RNA binding site [nucleotide binding]; other site 1045858002659 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1045858002660 RNA binding site [nucleotide binding]; other site 1045858002661 S1 RNA binding domain; Region: S1; pfam00575 1045858002662 RNA binding site [nucleotide binding]; other site 1045858002663 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045858002664 RNA binding site [nucleotide binding]; other site 1045858002665 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1045858002666 RNA binding site [nucleotide binding]; other site 1045858002667 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1045858002668 RNA binding site [nucleotide binding]; other site 1045858002669 monogalactosyldiacylglycerol synthase; Region: PLN02605 1045858002670 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1045858002671 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045858002672 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045858002673 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1045858002674 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1045858002675 trimerization site [polypeptide binding]; other site 1045858002676 active site 1045858002677 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045858002678 NifU-like domain; Region: NifU; pfam01106 1045858002679 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1045858002680 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1045858002681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858002682 catalytic residue [active] 1045858002683 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1045858002684 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1045858002685 metal binding site [ion binding]; metal-binding site 1045858002686 dimer interface [polypeptide binding]; other site 1045858002687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858002688 FeS/SAM binding site; other site 1045858002689 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045858002690 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1045858002691 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1045858002692 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1045858002693 GDP-Fucose binding site [chemical binding]; other site 1045858002694 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1045858002695 putative hydrolase; Validated; Region: PRK09248 1045858002696 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1045858002697 active site 1045858002698 imidazolonepropionase; Validated; Region: PRK09356 1045858002699 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1045858002700 active site 1045858002701 TPR repeat; Region: TPR_11; pfam13414 1045858002702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002703 binding surface 1045858002704 TPR motif; other site 1045858002705 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 1045858002706 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1045858002707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858002708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858002709 homodimer interface [polypeptide binding]; other site 1045858002710 catalytic residue [active] 1045858002711 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1045858002712 binuclear metal center [ion binding]; other site 1045858002713 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1045858002714 Rubredoxin; Region: Rubredoxin; pfam00301 1045858002715 iron binding site [ion binding]; other site 1045858002716 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1045858002717 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1045858002718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045858002719 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1045858002720 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1045858002721 hinge; other site 1045858002722 active site 1045858002723 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1045858002724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858002725 substrate binding pocket [chemical binding]; other site 1045858002726 membrane-bound complex binding site; other site 1045858002727 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1045858002728 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1045858002729 Ligand binding site; other site 1045858002730 Putative Catalytic site; other site 1045858002731 DXD motif; other site 1045858002732 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858002733 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1045858002734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858002735 FeS/SAM binding site; other site 1045858002736 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1045858002737 Protein of unknown function (DUF556); Region: DUF556; cl00822 1045858002738 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1045858002739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045858002740 nucleotide binding site [chemical binding]; other site 1045858002741 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1045858002742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045858002743 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045858002744 xylose isomerase; Provisional; Region: PRK05474 1045858002745 xylose isomerase; Region: xylose_isom_A; TIGR02630 1045858002746 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1045858002747 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1045858002748 putative ligand binding site [chemical binding]; other site 1045858002749 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1045858002750 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045858002751 Walker A/P-loop; other site 1045858002752 ATP binding site [chemical binding]; other site 1045858002753 Q-loop/lid; other site 1045858002754 ABC transporter signature motif; other site 1045858002755 Walker B; other site 1045858002756 D-loop; other site 1045858002757 H-loop/switch region; other site 1045858002758 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045858002759 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045858002760 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045858002761 TM-ABC transporter signature motif; other site 1045858002762 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1045858002763 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1045858002764 Walker A/P-loop; other site 1045858002765 ATP binding site [chemical binding]; other site 1045858002766 Q-loop/lid; other site 1045858002767 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1045858002768 ABC transporter signature motif; other site 1045858002769 Walker B; other site 1045858002770 D-loop; other site 1045858002771 H-loop/switch region; other site 1045858002772 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1045858002773 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1045858002774 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1045858002775 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1045858002776 putative acyl-acceptor binding pocket; other site 1045858002777 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 1045858002778 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1045858002779 4Fe-4S binding domain; Region: Fer4; pfam00037 1045858002780 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1045858002781 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858002782 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002783 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002784 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002785 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1045858002786 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1045858002787 Interdomain contacts; other site 1045858002788 Cytokine receptor motif; other site 1045858002789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858002790 binding surface 1045858002791 TPR motif; other site 1045858002792 TPR repeat; Region: TPR_11; pfam13414 1045858002793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002794 binding surface 1045858002795 TPR motif; other site 1045858002796 TPR repeat; Region: TPR_11; pfam13414 1045858002797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002798 binding surface 1045858002799 TPR motif; other site 1045858002800 TPR repeat; Region: TPR_11; pfam13414 1045858002801 TPR repeat; Region: TPR_11; pfam13414 1045858002802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002803 binding surface 1045858002804 TPR motif; other site 1045858002805 TPR repeat; Region: TPR_11; pfam13414 1045858002806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002807 binding surface 1045858002808 TPR repeat; Region: TPR_11; pfam13414 1045858002809 TPR motif; other site 1045858002810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002811 binding surface 1045858002812 TPR repeat; Region: TPR_11; pfam13414 1045858002813 TPR motif; other site 1045858002814 TM2 domain; Region: TM2; pfam05154 1045858002815 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 1045858002816 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1045858002817 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1045858002818 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1045858002819 nucleophile elbow; other site 1045858002820 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1045858002821 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1045858002822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858002823 ATP binding site [chemical binding]; other site 1045858002824 putative Mg++ binding site [ion binding]; other site 1045858002825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045858002826 nucleotide binding region [chemical binding]; other site 1045858002827 ATP-binding site [chemical binding]; other site 1045858002828 Leucine rich repeat; Region: LRR_8; pfam13855 1045858002829 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1045858002830 Leucine rich repeat; Region: LRR_8; pfam13855 1045858002831 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1045858002832 Ferritin-like domain; Region: Ferritin; pfam00210 1045858002833 ferroxidase diiron center [ion binding]; other site 1045858002834 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1045858002835 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1045858002836 Walker A/P-loop; other site 1045858002837 ATP binding site [chemical binding]; other site 1045858002838 Q-loop/lid; other site 1045858002839 ABC transporter signature motif; other site 1045858002840 Walker B; other site 1045858002841 D-loop; other site 1045858002842 H-loop/switch region; other site 1045858002843 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1045858002844 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1045858002845 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1045858002846 Peptidase family U32; Region: Peptidase_U32; pfam01136 1045858002847 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858002848 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1045858002849 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1045858002850 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1045858002851 Response regulator receiver domain; Region: Response_reg; pfam00072 1045858002852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858002853 active site 1045858002854 phosphorylation site [posttranslational modification] 1045858002855 intermolecular recognition site; other site 1045858002856 dimerization interface [polypeptide binding]; other site 1045858002857 ADP-glucose phosphorylase; Region: PLN02643 1045858002858 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1045858002859 nucleotide binding site/active site [active] 1045858002860 HIT family signature motif; other site 1045858002861 catalytic residue [active] 1045858002862 gamma-glutamyl kinase; Provisional; Region: PRK05429 1045858002863 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1045858002864 nucleotide binding site [chemical binding]; other site 1045858002865 homotetrameric interface [polypeptide binding]; other site 1045858002866 putative phosphate binding site [ion binding]; other site 1045858002867 putative allosteric binding site; other site 1045858002868 PUA domain; Region: PUA; pfam01472 1045858002869 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002870 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002871 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858002872 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858002873 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1045858002874 hypothetical protein; Provisional; Region: PRK01346 1045858002875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1045858002876 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1045858002877 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858002878 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1045858002879 TRAM domain; Region: TRAM; pfam01938 1045858002880 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1045858002881 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1045858002882 active site 1045858002883 nucleotide binding site [chemical binding]; other site 1045858002884 HIGH motif; other site 1045858002885 KMSKS motif; other site 1045858002886 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1045858002887 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1045858002888 NADP binding site [chemical binding]; other site 1045858002889 homopentamer interface [polypeptide binding]; other site 1045858002890 substrate binding site [chemical binding]; other site 1045858002891 active site 1045858002892 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858002893 Response regulator receiver domain; Region: Response_reg; pfam00072 1045858002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858002895 active site 1045858002896 phosphorylation site [posttranslational modification] 1045858002897 intermolecular recognition site; other site 1045858002898 dimerization interface [polypeptide binding]; other site 1045858002899 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1045858002900 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1045858002901 active site 1045858002902 HIGH motif; other site 1045858002903 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1045858002904 active site 1045858002905 KMSKS motif; other site 1045858002906 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1045858002907 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1045858002908 catalytic site [active] 1045858002909 G-X2-G-X-G-K; other site 1045858002910 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1045858002911 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1045858002912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002913 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858002914 TPR motif; other site 1045858002915 binding surface 1045858002916 Competence-damaged protein; Region: CinA; pfam02464 1045858002917 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1045858002918 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1045858002919 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1045858002920 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1045858002921 FliG C-terminal domain; Region: FliG_C; pfam01706 1045858002922 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1045858002923 Flagellar assembly protein FliH; Region: FliH; pfam02108 1045858002924 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 1045858002925 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1045858002926 Walker A motif/ATP binding site; other site 1045858002927 Walker B motif; other site 1045858002928 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1045858002929 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045858002930 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045858002931 catalytic residue [active] 1045858002932 NHL repeat; Region: NHL; pfam01436 1045858002933 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 1045858002934 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1045858002935 RNB domain; Region: RNB; pfam00773 1045858002936 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1045858002937 RNA binding site [nucleotide binding]; other site 1045858002938 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858002939 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858002940 TolB amino-terminal domain; Region: TolB_N; pfam04052 1045858002941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002942 binding surface 1045858002943 TPR motif; other site 1045858002944 TPR repeat; Region: TPR_11; pfam13414 1045858002945 TPR repeat; Region: TPR_11; pfam13414 1045858002946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002947 binding surface 1045858002948 TPR motif; other site 1045858002949 TPR repeat; Region: TPR_11; pfam13414 1045858002950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858002951 binding surface 1045858002952 TPR motif; other site 1045858002953 TPR repeat; Region: TPR_11; pfam13414 1045858002954 EamA-like transporter family; Region: EamA; pfam00892 1045858002955 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045858002956 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1045858002957 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1045858002958 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1045858002959 active site 1045858002960 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1045858002961 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858002962 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858002963 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1045858002964 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1045858002965 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858002966 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858002967 active site 1045858002968 catalytic tetrad [active] 1045858002969 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1045858002970 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1045858002971 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1045858002972 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1045858002973 DNA binding residues [nucleotide binding] 1045858002974 putative dimer interface [polypeptide binding]; other site 1045858002975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045858002976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045858002977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045858002978 dimerization interface [polypeptide binding]; other site 1045858002979 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1045858002980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045858002981 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858002982 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1045858002983 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1045858002984 trimer interface [polypeptide binding]; other site 1045858002985 active site 1045858002986 substrate binding site [chemical binding]; other site 1045858002987 CoA binding site [chemical binding]; other site 1045858002988 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858002989 Protein export membrane protein; Region: SecD_SecF; cl14618 1045858002990 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1045858002991 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1045858002992 anti sigma factor interaction site; other site 1045858002993 regulatory phosphorylation site [posttranslational modification]; other site 1045858002994 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1045858002995 TPR repeat; Region: TPR_11; pfam13414 1045858002996 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858002997 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1045858002998 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1045858002999 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1045858003000 ZIP Zinc transporter; Region: Zip; pfam02535 1045858003001 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1045858003002 nucleotide binding site/active site [active] 1045858003003 HIT family signature motif; other site 1045858003004 catalytic residue [active] 1045858003005 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1045858003006 active site 1045858003007 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 1045858003008 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1045858003009 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1045858003010 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1045858003011 replicative DNA helicase; Region: DnaB; TIGR00665 1045858003012 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1045858003013 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1045858003014 Walker A motif; other site 1045858003015 ATP binding site [chemical binding]; other site 1045858003016 Walker B motif; other site 1045858003017 DNA binding loops [nucleotide binding] 1045858003018 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1045858003019 Permease; Region: Permease; pfam02405 1045858003020 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1045858003021 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045858003022 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045858003023 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045858003024 glycogen synthase; Provisional; Region: glgA; PRK00654 1045858003025 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1045858003026 ADP-binding pocket [chemical binding]; other site 1045858003027 homodimer interface [polypeptide binding]; other site 1045858003028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1045858003029 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1045858003030 LexA repressor; Validated; Region: PRK00215 1045858003031 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1045858003032 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1045858003033 Catalytic site [active] 1045858003034 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1045858003035 putative CheA interaction surface; other site 1045858003036 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1045858003037 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1045858003038 DHH family; Region: DHH; pfam01368 1045858003039 DHHA1 domain; Region: DHHA1; pfam02272 1045858003040 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1045858003041 RNA/DNA hybrid binding site [nucleotide binding]; other site 1045858003042 active site 1045858003043 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1045858003044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003045 dimer interface [polypeptide binding]; other site 1045858003046 conserved gate region; other site 1045858003047 ABC-ATPase subunit interface; other site 1045858003048 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1045858003049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003050 dimer interface [polypeptide binding]; other site 1045858003051 conserved gate region; other site 1045858003052 putative PBP binding loops; other site 1045858003053 ABC-ATPase subunit interface; other site 1045858003054 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1045858003055 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045858003056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858003057 Coenzyme A binding pocket [chemical binding]; other site 1045858003058 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1045858003059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858003060 S-adenosylmethionine binding site [chemical binding]; other site 1045858003061 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858003062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858003063 Walker A/P-loop; other site 1045858003064 ATP binding site [chemical binding]; other site 1045858003065 AAA domain; Region: AAA_21; pfam13304 1045858003066 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003067 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003069 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003070 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003071 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003072 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1045858003073 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1045858003074 catalytic triad [active] 1045858003075 conserved cis-peptide bond; other site 1045858003076 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1045858003077 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1045858003078 DNA binding site [nucleotide binding] 1045858003079 active site 1045858003080 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1045858003081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1045858003082 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1045858003083 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1045858003084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858003085 Walker A motif; other site 1045858003086 ATP binding site [chemical binding]; other site 1045858003087 Walker B motif; other site 1045858003088 arginine finger; other site 1045858003089 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1045858003090 DnaA box-binding interface [nucleotide binding]; other site 1045858003091 GrpE; Region: GrpE; pfam01025 1045858003092 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1045858003093 dimer interface [polypeptide binding]; other site 1045858003094 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1045858003095 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1045858003096 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1045858003097 NEF interaction site [polypeptide binding]; other site 1045858003098 nucleotide binding site [chemical binding]; other site 1045858003099 SBD interface [polypeptide binding]; other site 1045858003100 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003101 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1045858003102 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003103 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003104 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003105 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003106 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003107 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1045858003108 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045858003109 HSP70 interaction site [polypeptide binding]; other site 1045858003110 chaperone protein DnaJ; Provisional; Region: PRK10767 1045858003111 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1045858003112 HSP70 interaction site [polypeptide binding]; other site 1045858003113 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1045858003114 substrate binding site [polypeptide binding]; other site 1045858003115 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1045858003116 Zn binding sites [ion binding]; other site 1045858003117 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1045858003118 dimer interface [polypeptide binding]; other site 1045858003119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1045858003120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003121 TPR motif; other site 1045858003122 binding surface 1045858003123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003124 TPR motif; other site 1045858003125 TPR repeat; Region: TPR_11; pfam13414 1045858003126 binding surface 1045858003127 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1045858003128 dimer interface [polypeptide binding]; other site 1045858003129 pyridoxal binding site [chemical binding]; other site 1045858003130 ATP binding site [chemical binding]; other site 1045858003131 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1045858003132 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1045858003133 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045858003134 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1045858003135 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1045858003136 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045858003137 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1045858003138 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1045858003139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003140 TPR motif; other site 1045858003141 binding surface 1045858003142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003143 binding surface 1045858003144 TPR motif; other site 1045858003145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003146 binding surface 1045858003147 TPR motif; other site 1045858003148 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1045858003149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858003150 S-adenosylmethionine binding site [chemical binding]; other site 1045858003151 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 1045858003152 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 1045858003153 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1045858003154 active site 1045858003155 catalytic site [active] 1045858003156 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 1045858003157 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1045858003158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045858003159 RNA binding surface [nucleotide binding]; other site 1045858003160 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1045858003161 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003162 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003163 ligand binding site [chemical binding]; other site 1045858003164 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003165 ligand binding site [chemical binding]; other site 1045858003166 flexible hinge region; other site 1045858003167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003169 ligand binding site [chemical binding]; other site 1045858003170 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003171 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003172 ligand binding site [chemical binding]; other site 1045858003173 flexible hinge region; other site 1045858003174 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003175 ligand binding site [chemical binding]; other site 1045858003176 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003177 ligand binding site [chemical binding]; other site 1045858003178 flexible hinge region; other site 1045858003179 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003180 ligand binding site [chemical binding]; other site 1045858003181 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1045858003182 ligand binding site [chemical binding]; other site 1045858003183 flexible hinge region; other site 1045858003184 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003185 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003186 ligand binding site [chemical binding]; other site 1045858003187 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003188 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003189 ligand binding site [chemical binding]; other site 1045858003190 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003191 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003192 ligand binding site [chemical binding]; other site 1045858003193 flexible hinge region; other site 1045858003194 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003195 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003196 ligand binding site [chemical binding]; other site 1045858003197 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858003198 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858003199 ligand binding site [chemical binding]; other site 1045858003200 flexible hinge region; other site 1045858003201 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1045858003202 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 1045858003203 catalytic Zn binding site [ion binding]; other site 1045858003204 NAD(P) binding site [chemical binding]; other site 1045858003205 structural Zn binding site [ion binding]; other site 1045858003206 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 1045858003207 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003208 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003209 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003210 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003211 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003212 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003213 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003214 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003215 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858003216 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003218 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1045858003219 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1045858003220 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1045858003221 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1045858003222 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1045858003223 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1045858003224 putative active site [active] 1045858003225 putative metal binding site [ion binding]; other site 1045858003226 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1045858003227 Domain of unknown function DUF21; Region: DUF21; pfam01595 1045858003228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045858003229 Transporter associated domain; Region: CorC_HlyC; smart01091 1045858003230 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1045858003231 substrate binding site [chemical binding]; other site 1045858003232 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1045858003233 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1045858003234 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1045858003235 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1045858003236 active site 1045858003237 PHP Thumb interface [polypeptide binding]; other site 1045858003238 metal binding site [ion binding]; metal-binding site 1045858003239 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1045858003240 Clp amino terminal domain; Region: Clp_N; pfam02861 1045858003241 Clp amino terminal domain; Region: Clp_N; pfam02861 1045858003242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858003243 Walker A motif; other site 1045858003244 ATP binding site [chemical binding]; other site 1045858003245 Walker B motif; other site 1045858003246 arginine finger; other site 1045858003247 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 1045858003248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858003249 Walker A motif; other site 1045858003250 ATP binding site [chemical binding]; other site 1045858003251 Walker B motif; other site 1045858003252 arginine finger; other site 1045858003253 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1045858003254 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1045858003255 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1045858003256 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1045858003257 methionine sulfoxide reductase B; Provisional; Region: PRK05508 1045858003258 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1045858003259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858003260 Coenzyme A binding pocket [chemical binding]; other site 1045858003261 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1045858003262 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1045858003263 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1045858003264 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1045858003265 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1045858003266 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 1045858003267 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045858003268 PYR/PP interface [polypeptide binding]; other site 1045858003269 dimer interface [polypeptide binding]; other site 1045858003270 TPP binding site [chemical binding]; other site 1045858003271 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 1045858003272 TPP-binding site; other site 1045858003273 potential frameshift: common BLAST hit: gi|326792637|ref|YP_004310458.1| phosphoenolpyruvate phosphomutase 1045858003274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858003275 active site 1045858003276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045858003277 active site 1045858003278 HIGH motif; other site 1045858003279 nucleotide binding site [chemical binding]; other site 1045858003280 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1045858003281 tetramer interface [polypeptide binding]; other site 1045858003282 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1045858003283 active site 1045858003284 Mg2+/Mn2+ binding site [ion binding]; other site 1045858003285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045858003286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858003287 catalytic residue [active] 1045858003288 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1045858003289 active site 1045858003290 metal-binding site 1045858003291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858003292 putative substrate translocation pore; other site 1045858003293 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1045858003294 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 1045858003295 Sulfatase; Region: Sulfatase; cl17466 1045858003296 Stage II sporulation protein; Region: SpoIID; pfam08486 1045858003297 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1045858003298 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1045858003299 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1045858003300 NAD(P) binding site [chemical binding]; other site 1045858003301 catalytic residues [active] 1045858003302 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858003303 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1045858003304 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045858003305 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045858003306 catalytic residue [active] 1045858003307 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858003308 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1045858003309 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1045858003310 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045858003311 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045858003312 catalytic residue [active] 1045858003313 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858003314 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1045858003315 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1045858003316 homodimer interface [polypeptide binding]; other site 1045858003317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858003318 catalytic residue [active] 1045858003319 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1045858003320 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1045858003321 ligand binding site [chemical binding]; other site 1045858003322 NAD binding site [chemical binding]; other site 1045858003323 dimerization interface [polypeptide binding]; other site 1045858003324 catalytic site [active] 1045858003325 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1045858003326 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1045858003327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858003328 motif II; other site 1045858003329 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1045858003330 Citrate synthase; Region: Citrate_synt; pfam00285 1045858003331 oxalacetate binding site [chemical binding]; other site 1045858003332 citrylCoA binding site [chemical binding]; other site 1045858003333 coenzyme A binding site [chemical binding]; other site 1045858003334 catalytic triad [active] 1045858003335 isocitrate dehydrogenase; Validated; Region: PRK07362 1045858003336 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1045858003337 aconitate hydratase; Validated; Region: PRK07229 1045858003338 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1045858003339 substrate binding site [chemical binding]; other site 1045858003340 ligand binding site [chemical binding]; other site 1045858003341 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1045858003342 substrate binding site [chemical binding]; other site 1045858003343 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1045858003344 dimer interface [polypeptide binding]; other site 1045858003345 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1045858003346 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1045858003347 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1045858003348 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045858003349 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1045858003350 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1045858003351 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1045858003352 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1045858003353 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1045858003354 acyl-activating enzyme (AAE) consensus motif; other site 1045858003355 putative AMP binding site [chemical binding]; other site 1045858003356 putative active site [active] 1045858003357 putative CoA binding site [chemical binding]; other site 1045858003358 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1045858003359 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1045858003360 Cache domain; Region: Cache_1; pfam02743 1045858003361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858003362 dimerization interface [polypeptide binding]; other site 1045858003363 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858003364 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858003365 dimer interface [polypeptide binding]; other site 1045858003366 putative CheW interface [polypeptide binding]; other site 1045858003367 Hemerythrin; Region: Hemerythrin; cd12107 1045858003368 Fe binding site [ion binding]; other site 1045858003369 Cache domain; Region: Cache_1; pfam02743 1045858003370 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1045858003371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858003372 dimerization interface [polypeptide binding]; other site 1045858003373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858003374 dimer interface [polypeptide binding]; other site 1045858003375 putative CheW interface [polypeptide binding]; other site 1045858003376 Hemerythrin; Region: Hemerythrin; cd12107 1045858003377 Fe binding site [ion binding]; other site 1045858003378 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 1045858003379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045858003380 GAF domain; Region: GAF_3; pfam13492 1045858003381 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1045858003382 GAF domain; Region: GAF; pfam01590 1045858003383 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1045858003384 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1045858003385 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858003386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858003387 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858003388 active site 1045858003389 catalytic tetrad [active] 1045858003390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858003391 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858003392 active site 1045858003393 catalytic tetrad [active] 1045858003394 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858003395 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858003396 active site 1045858003397 catalytic tetrad [active] 1045858003398 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1045858003399 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1045858003400 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1045858003401 DNA binding residues [nucleotide binding] 1045858003402 putative dimer interface [polypeptide binding]; other site 1045858003403 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1045858003404 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1045858003405 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1045858003406 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1045858003407 AMP binding site [chemical binding]; other site 1045858003408 active site 1045858003409 acyl-activating enzyme (AAE) consensus motif; other site 1045858003410 CoA binding site [chemical binding]; other site 1045858003411 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1045858003412 putative acyl-acceptor binding pocket; other site 1045858003413 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1045858003414 active site 1045858003415 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1045858003416 Predicted exporter [General function prediction only]; Region: COG4258 1045858003417 Predicted exporter [General function prediction only]; Region: COG4258 1045858003418 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045858003419 active site 1045858003420 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1045858003421 active site 2 [active] 1045858003422 active site 1 [active] 1045858003423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1045858003424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858003425 NAD(P) binding site [chemical binding]; other site 1045858003426 active site 1045858003427 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003428 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003429 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003430 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1045858003431 dimer interface [polypeptide binding]; other site 1045858003432 active site 1045858003433 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1045858003434 zinc binding site [ion binding]; other site 1045858003435 putative ligand binding site [chemical binding]; other site 1045858003436 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1045858003437 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045858003438 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1045858003439 putative active site [active] 1045858003440 putative hydrolase; Provisional; Region: PRK02113 1045858003441 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1045858003442 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1045858003443 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1045858003444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1045858003445 Divalent cation transporter; Region: MgtE; pfam01769 1045858003446 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858003447 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003448 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003449 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003450 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003451 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858003452 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858003453 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003454 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003455 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003456 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003457 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003458 EamA-like transporter family; Region: EamA; pfam00892 1045858003459 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1045858003460 EamA-like transporter family; Region: EamA; pfam00892 1045858003461 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1045858003462 FOG: CBS domain [General function prediction only]; Region: COG0517 1045858003463 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1045858003464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1045858003465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1045858003466 metal binding site [ion binding]; metal-binding site 1045858003467 active site 1045858003468 I-site; other site 1045858003469 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1045858003470 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1045858003471 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1045858003472 active site 1045858003473 homodimer interface [polypeptide binding]; other site 1045858003474 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1045858003475 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045858003476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045858003477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045858003478 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1045858003479 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1045858003480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1045858003481 YheO-like PAS domain; Region: PAS_6; pfam08348 1045858003482 HTH domain; Region: HTH_22; pfam13309 1045858003483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1045858003484 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1045858003485 active site 1045858003486 DNA binding site [nucleotide binding] 1045858003487 Int/Topo IB signature motif; other site 1045858003488 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1045858003489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858003490 membrane-bound complex binding site; other site 1045858003491 hinge residues; other site 1045858003492 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1045858003493 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1045858003494 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858003495 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1045858003496 HflX GTPase family; Region: HflX; cd01878 1045858003497 G1 box; other site 1045858003498 GTP/Mg2+ binding site [chemical binding]; other site 1045858003499 Switch I region; other site 1045858003500 G2 box; other site 1045858003501 G3 box; other site 1045858003502 Switch II region; other site 1045858003503 G4 box; other site 1045858003504 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1045858003505 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1045858003506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045858003507 Walker A/P-loop; other site 1045858003508 ATP binding site [chemical binding]; other site 1045858003509 Q-loop/lid; other site 1045858003510 ABC transporter signature motif; other site 1045858003511 Walker B; other site 1045858003512 D-loop; other site 1045858003513 H-loop/switch region; other site 1045858003514 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045858003515 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1045858003516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1045858003517 Walker A/P-loop; other site 1045858003518 ATP binding site [chemical binding]; other site 1045858003519 Q-loop/lid; other site 1045858003520 ABC transporter signature motif; other site 1045858003521 Walker B; other site 1045858003522 D-loop; other site 1045858003523 H-loop/switch region; other site 1045858003524 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1045858003525 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1045858003526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1045858003527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1045858003528 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1045858003529 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1045858003530 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1045858003531 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1045858003532 GTP/Mg2+ binding site [chemical binding]; other site 1045858003533 G4 box; other site 1045858003534 G5 box; other site 1045858003535 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1045858003536 G1 box; other site 1045858003537 G1 box; other site 1045858003538 GTP/Mg2+ binding site [chemical binding]; other site 1045858003539 Switch I region; other site 1045858003540 Switch I region; other site 1045858003541 G2 box; other site 1045858003542 G2 box; other site 1045858003543 Switch II region; other site 1045858003544 G3 box; other site 1045858003545 G3 box; other site 1045858003546 Switch II region; other site 1045858003547 G4 box; other site 1045858003548 G5 box; other site 1045858003549 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1045858003550 TraB family; Region: TraB; cl12050 1045858003551 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1045858003552 Transglycosylase; Region: Transgly; pfam00912 1045858003553 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045858003554 META domain; Region: META; pfam03724 1045858003555 META domain; Region: META; pfam03724 1045858003556 META domain; Region: META; pfam03724 1045858003557 META domain; Region: META; pfam03724 1045858003558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045858003559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858003560 Coenzyme A binding pocket [chemical binding]; other site 1045858003561 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1045858003562 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1045858003563 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1045858003564 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1045858003565 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1045858003566 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1045858003567 FHIPEP family; Region: FHIPEP; pfam00771 1045858003568 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1045858003569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858003570 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1045858003571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045858003572 Walker A/P-loop; other site 1045858003573 ATP binding site [chemical binding]; other site 1045858003574 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1045858003575 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1045858003576 P-loop; other site 1045858003577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045858003578 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 1045858003579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045858003580 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045858003581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858003582 DNA binding residues [nucleotide binding] 1045858003583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858003584 DNA binding residues [nucleotide binding] 1045858003585 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1045858003586 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1045858003587 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1045858003588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858003589 motif II; other site 1045858003590 Recombination protein O C terminal; Region: RecO_C; pfam02565 1045858003591 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1045858003592 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1045858003593 homoserine dehydrogenase; Provisional; Region: PRK06349 1045858003594 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1045858003595 selenocysteine synthase; Provisional; Region: PRK04311 1045858003596 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045858003597 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1045858003598 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1045858003599 G1 box; other site 1045858003600 putative GEF interaction site [polypeptide binding]; other site 1045858003601 GTP/Mg2+ binding site [chemical binding]; other site 1045858003602 Switch I region; other site 1045858003603 G2 box; other site 1045858003604 G3 box; other site 1045858003605 Switch II region; other site 1045858003606 G4 box; other site 1045858003607 G5 box; other site 1045858003608 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1045858003609 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1045858003610 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1045858003611 dimer interface [polypeptide binding]; other site 1045858003612 putative tRNA-binding site [nucleotide binding]; other site 1045858003613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003614 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858003615 binding surface 1045858003616 TPR motif; other site 1045858003617 excinuclease ABC subunit B; Provisional; Region: PRK05298 1045858003618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858003619 ATP binding site [chemical binding]; other site 1045858003620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045858003621 nucleotide binding region [chemical binding]; other site 1045858003622 ATP-binding site [chemical binding]; other site 1045858003623 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1045858003624 UvrB/uvrC motif; Region: UVR; pfam02151 1045858003625 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045858003626 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045858003627 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045858003628 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045858003629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003630 binding surface 1045858003631 TPR motif; other site 1045858003632 TPR repeat; Region: TPR_11; pfam13414 1045858003633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003634 TPR motif; other site 1045858003635 binding surface 1045858003636 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1045858003637 nucleophile elbow; other site 1045858003638 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1045858003639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1045858003640 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1045858003641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858003642 motif II; other site 1045858003643 MoxR-like ATPases [General function prediction only]; Region: COG0714 1045858003644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858003645 Walker A motif; other site 1045858003646 ATP binding site [chemical binding]; other site 1045858003647 Walker B motif; other site 1045858003648 arginine finger; other site 1045858003649 hypothetical protein; Provisional; Region: yieM; PRK10997 1045858003650 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1045858003651 metal ion-dependent adhesion site (MIDAS); other site 1045858003652 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1045858003653 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 1045858003654 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1045858003655 active site 1045858003656 catalytic residues [active] 1045858003657 metal binding site [ion binding]; metal-binding site 1045858003658 homodimer binding site [polypeptide binding]; other site 1045858003659 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1045858003660 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045858003661 carboxyltransferase (CT) interaction site; other site 1045858003662 biotinylation site [posttranslational modification]; other site 1045858003663 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1045858003664 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1045858003665 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1045858003666 Ligand binding site; other site 1045858003667 Putative Catalytic site; other site 1045858003668 DXD motif; other site 1045858003669 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1045858003670 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1045858003671 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1045858003672 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1045858003673 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045858003674 Predicted transcriptional regulators [Transcription]; Region: COG1733 1045858003675 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1045858003676 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045858003677 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045858003678 active site 1045858003679 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858003680 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1045858003681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858003682 Walker A/P-loop; other site 1045858003683 ATP binding site [chemical binding]; other site 1045858003684 Q-loop/lid; other site 1045858003685 ABC transporter signature motif; other site 1045858003686 Walker B; other site 1045858003687 D-loop; other site 1045858003688 H-loop/switch region; other site 1045858003689 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1045858003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003691 putative PBP binding loops; other site 1045858003692 dimer interface [polypeptide binding]; other site 1045858003693 ABC-ATPase subunit interface; other site 1045858003694 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1045858003695 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1045858003696 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1045858003697 MPT binding site; other site 1045858003698 trimer interface [polypeptide binding]; other site 1045858003699 MOSC domain; Region: MOSC; pfam03473 1045858003700 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1045858003701 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1045858003702 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1045858003703 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1045858003704 dimer interface [polypeptide binding]; other site 1045858003705 putative functional site; other site 1045858003706 putative MPT binding site; other site 1045858003707 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1045858003708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858003709 FeS/SAM binding site; other site 1045858003710 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1045858003711 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 1045858003712 trimer interface [polypeptide binding]; other site 1045858003713 dimer interface [polypeptide binding]; other site 1045858003714 putative active site [active] 1045858003715 Cache domain; Region: Cache_1; pfam02743 1045858003716 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858003717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858003718 dimer interface [polypeptide binding]; other site 1045858003719 putative CheW interface [polypeptide binding]; other site 1045858003720 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858003721 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858003722 peptide binding site [polypeptide binding]; other site 1045858003723 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1045858003724 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1045858003725 metal binding site [ion binding]; metal-binding site 1045858003726 dimer interface [polypeptide binding]; other site 1045858003727 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1045858003728 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1045858003729 dimer interface [polypeptide binding]; other site 1045858003730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858003731 catalytic residue [active] 1045858003732 serine O-acetyltransferase; Region: cysE; TIGR01172 1045858003733 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1045858003734 trimer interface [polypeptide binding]; other site 1045858003735 active site 1045858003736 substrate binding site [chemical binding]; other site 1045858003737 CoA binding site [chemical binding]; other site 1045858003738 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045858003739 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1045858003740 substrate binding site [chemical binding]; other site 1045858003741 ATP binding site [chemical binding]; other site 1045858003742 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1045858003743 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1045858003744 nucleotide binding site [chemical binding]; other site 1045858003745 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1045858003746 rRNA interaction site [nucleotide binding]; other site 1045858003747 S8 interaction site; other site 1045858003748 putative laminin-1 binding site; other site 1045858003749 elongation factor Ts; Provisional; Region: tsf; PRK09377 1045858003750 UBA/TS-N domain; Region: UBA; pfam00627 1045858003751 Elongation factor TS; Region: EF_TS; pfam00889 1045858003752 Elongation factor TS; Region: EF_TS; pfam00889 1045858003753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003754 TPR motif; other site 1045858003755 binding surface 1045858003756 TPR repeat; Region: TPR_11; pfam13414 1045858003757 TPR repeat; Region: TPR_11; pfam13414 1045858003758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858003759 binding surface 1045858003760 TPR motif; other site 1045858003761 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1045858003762 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1045858003763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1045858003764 phosphate binding site [ion binding]; other site 1045858003765 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1045858003766 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858003767 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1045858003768 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858003769 Sulfatase; Region: Sulfatase; pfam00884 1045858003770 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858003771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045858003772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045858003773 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045858003774 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045858003775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003776 dimer interface [polypeptide binding]; other site 1045858003777 conserved gate region; other site 1045858003778 putative PBP binding loops; other site 1045858003779 ABC-ATPase subunit interface; other site 1045858003780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045858003781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003782 dimer interface [polypeptide binding]; other site 1045858003783 conserved gate region; other site 1045858003784 putative PBP binding loops; other site 1045858003785 ABC-ATPase subunit interface; other site 1045858003786 Sulfatase; Region: Sulfatase; cl17466 1045858003787 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858003788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1045858003789 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1045858003790 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045858003791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003792 dimer interface [polypeptide binding]; other site 1045858003793 conserved gate region; other site 1045858003794 putative PBP binding loops; other site 1045858003795 ABC-ATPase subunit interface; other site 1045858003796 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045858003797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858003798 dimer interface [polypeptide binding]; other site 1045858003799 conserved gate region; other site 1045858003800 putative PBP binding loops; other site 1045858003801 ABC-ATPase subunit interface; other site 1045858003802 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1045858003803 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045858003804 Walker A/P-loop; other site 1045858003805 ATP binding site [chemical binding]; other site 1045858003806 Q-loop/lid; other site 1045858003807 ABC transporter signature motif; other site 1045858003808 Walker B; other site 1045858003809 D-loop; other site 1045858003810 H-loop/switch region; other site 1045858003811 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1045858003812 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045858003813 Walker A/P-loop; other site 1045858003814 ATP binding site [chemical binding]; other site 1045858003815 Q-loop/lid; other site 1045858003816 ABC transporter signature motif; other site 1045858003817 Walker B; other site 1045858003818 D-loop; other site 1045858003819 H-loop/switch region; other site 1045858003820 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045858003821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045858003822 DNA binding site [nucleotide binding] 1045858003823 domain linker motif; other site 1045858003824 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1045858003825 ligand binding site [chemical binding]; other site 1045858003826 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1045858003827 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045858003828 catalytic residue [active] 1045858003829 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1045858003830 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1045858003831 Glycoprotease family; Region: Peptidase_M22; pfam00814 1045858003832 Cache domain; Region: Cache_1; pfam02743 1045858003833 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858003834 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858003835 dimer interface [polypeptide binding]; other site 1045858003836 putative CheW interface [polypeptide binding]; other site 1045858003837 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1045858003838 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1045858003839 active site residue [active] 1045858003840 AAA domain; Region: AAA_17; pfam13207 1045858003841 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1045858003842 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1045858003843 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1045858003844 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1045858003845 active site 1045858003846 HIGH motif; other site 1045858003847 dimer interface [polypeptide binding]; other site 1045858003848 KMSKS motif; other site 1045858003849 YceG-like family; Region: YceG; pfam02618 1045858003850 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1045858003851 dimerization interface [polypeptide binding]; other site 1045858003852 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1045858003853 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1045858003854 dimer interface [polypeptide binding]; other site 1045858003855 motif 1; other site 1045858003856 active site 1045858003857 motif 2; other site 1045858003858 motif 3; other site 1045858003859 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1045858003860 anticodon binding site; other site 1045858003861 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1045858003862 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1045858003863 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1045858003864 chromosome segregation protein; Provisional; Region: PRK01156 1045858003865 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1045858003866 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1045858003867 trimer interface [polypeptide binding]; other site 1045858003868 active site 1045858003869 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1045858003870 GntP family permease; Region: GntP_permease; pfam02447 1045858003871 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045858003872 dimerization domain swap beta strand [polypeptide binding]; other site 1045858003873 regulatory protein interface [polypeptide binding]; other site 1045858003874 active site 1045858003875 regulatory phosphorylation site [posttranslational modification]; other site 1045858003876 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1045858003877 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045858003878 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045858003879 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1045858003880 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1045858003881 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045858003882 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1045858003883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858003884 Walker A/P-loop; other site 1045858003885 ATP binding site [chemical binding]; other site 1045858003886 Q-loop/lid; other site 1045858003887 ABC transporter signature motif; other site 1045858003888 Walker B; other site 1045858003889 D-loop; other site 1045858003890 H-loop/switch region; other site 1045858003891 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1045858003892 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1045858003893 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1045858003894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858003895 active site 1045858003896 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1045858003897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858003898 NAD(P) binding site [chemical binding]; other site 1045858003899 active site 1045858003900 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1045858003901 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045858003902 inhibitor-cofactor binding pocket; inhibition site 1045858003903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858003904 catalytic residue [active] 1045858003905 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1045858003906 active site 1045858003907 catalytic residues [active] 1045858003908 metal binding site [ion binding]; metal-binding site 1045858003909 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1045858003910 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045858003911 PYR/PP interface [polypeptide binding]; other site 1045858003912 dimer interface [polypeptide binding]; other site 1045858003913 TPP binding site [chemical binding]; other site 1045858003914 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045858003915 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1045858003916 TPP-binding site [chemical binding]; other site 1045858003917 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1045858003918 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1045858003919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1045858003920 NAD(P) binding site [chemical binding]; other site 1045858003921 active site 1045858003922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045858003923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045858003924 active site 1045858003925 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045858003926 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045858003927 active site 1045858003928 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045858003929 active site 1045858003930 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1045858003931 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1045858003932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858003933 FeS/SAM binding site; other site 1045858003934 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1045858003935 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1045858003936 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1045858003937 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1045858003938 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1045858003939 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1045858003940 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858003941 active site 1045858003942 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858003943 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1045858003944 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1045858003945 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1045858003946 substrate binding pocket [chemical binding]; other site 1045858003947 dimer interface [polypeptide binding]; other site 1045858003948 inhibitor binding site; inhibition site 1045858003949 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1045858003950 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1045858003951 B12 binding site [chemical binding]; other site 1045858003952 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1045858003953 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1045858003954 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1045858003955 FAD binding site [chemical binding]; other site 1045858003956 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858003957 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858003958 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1045858003959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858003960 active site 1045858003961 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1045858003962 putative trimer interface [polypeptide binding]; other site 1045858003963 putative CoA binding site [chemical binding]; other site 1045858003964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 1045858003965 Predicted permeases [General function prediction only]; Region: COG0795 1045858003966 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1045858003967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858003968 Coenzyme A binding pocket [chemical binding]; other site 1045858003969 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1045858003970 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1045858003971 dimer interface [polypeptide binding]; other site 1045858003972 motif 1; other site 1045858003973 active site 1045858003974 motif 2; other site 1045858003975 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1045858003976 putative deacylase active site [active] 1045858003977 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045858003978 active site 1045858003979 motif 3; other site 1045858003980 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1045858003981 anticodon binding site; other site 1045858003982 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1045858003983 GDP-Fucose binding site [chemical binding]; other site 1045858003984 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1045858003985 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1045858003986 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1045858003987 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1045858003988 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 1045858003989 Sulfatase; Region: Sulfatase; cl17466 1045858003990 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1045858003991 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1045858003992 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1045858003993 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003994 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003995 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858003996 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858003997 Ankyrin repeat; Region: Ank; pfam00023 1045858003998 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858003999 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004000 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004001 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004002 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004003 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004004 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858004005 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1045858004006 ligand binding site [chemical binding]; other site 1045858004007 flexible hinge region; other site 1045858004008 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1045858004009 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1045858004010 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1045858004011 ligand binding site [chemical binding]; other site 1045858004012 flexible hinge region; other site 1045858004013 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1045858004014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858004015 binding surface 1045858004016 TPR motif; other site 1045858004017 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 1045858004018 NAD synthetase; Provisional; Region: PRK13981 1045858004019 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1045858004020 multimer interface [polypeptide binding]; other site 1045858004021 active site 1045858004022 catalytic triad [active] 1045858004023 protein interface 1 [polypeptide binding]; other site 1045858004024 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1045858004025 Ligand Binding Site [chemical binding]; other site 1045858004026 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045858004027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858004028 active site 1045858004029 phosphorylation site [posttranslational modification] 1045858004030 intermolecular recognition site; other site 1045858004031 dimerization interface [polypeptide binding]; other site 1045858004032 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1045858004033 putative binding surface; other site 1045858004034 active site 1045858004035 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1045858004036 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1045858004037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858004038 ATP binding site [chemical binding]; other site 1045858004039 Mg2+ binding site [ion binding]; other site 1045858004040 G-X-G motif; other site 1045858004041 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1045858004042 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1045858004043 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1045858004044 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1045858004045 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1045858004046 CheD chemotactic sensory transduction; Region: CheD; cl00810 1045858004047 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1045858004048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858004049 active site 1045858004050 phosphorylation site [posttranslational modification] 1045858004051 intermolecular recognition site; other site 1045858004052 dimerization interface [polypeptide binding]; other site 1045858004053 CheB methylesterase; Region: CheB_methylest; pfam01339 1045858004054 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1045858004055 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1045858004056 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1045858004057 WYL domain; Region: WYL; pfam13280 1045858004058 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1045858004059 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1045858004060 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1045858004061 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1045858004062 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1045858004063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045858004064 Predicted transcriptional regulators [Transcription]; Region: COG1695 1045858004065 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1045858004066 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1045858004067 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1045858004068 Ca binding site [ion binding]; other site 1045858004069 active site 1045858004070 catalytic site [active] 1045858004071 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858004072 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1045858004073 active site turn [active] 1045858004074 phosphorylation site [posttranslational modification] 1045858004075 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045858004076 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1045858004077 HPr interaction site; other site 1045858004078 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045858004079 active site 1045858004080 phosphorylation site [posttranslational modification] 1045858004081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045858004082 DNA-binding site [nucleotide binding]; DNA binding site 1045858004083 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1045858004084 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1045858004085 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1045858004086 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858004087 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1045858004088 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1045858004089 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1045858004090 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1045858004091 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1045858004092 oligomer interface [polypeptide binding]; other site 1045858004093 active site residues [active] 1045858004094 Predicted chitinase [General function prediction only]; Region: COG3179 1045858004095 catalytic residue [active] 1045858004096 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1045858004097 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1045858004098 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1045858004099 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1045858004100 potential frameshift: common BLAST hit: gi|158523151|ref|YP_001531021.1| N-6 DNA methylase 1045858004101 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1045858004102 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1045858004103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1045858004104 non-specific DNA binding site [nucleotide binding]; other site 1045858004105 salt bridge; other site 1045858004106 sequence-specific DNA binding site [nucleotide binding]; other site 1045858004107 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1045858004108 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1045858004109 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1045858004110 active site 1045858004111 catalytic residues [active] 1045858004112 DNA binding site [nucleotide binding] 1045858004113 Int/Topo IB signature motif; other site 1045858004114 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1045858004115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858004116 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045858004117 Walker A motif; other site 1045858004118 ATP binding site [chemical binding]; other site 1045858004119 Walker B motif; other site 1045858004120 arginine finger; other site 1045858004121 UGMP family protein; Validated; Region: PRK09604 1045858004122 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1045858004123 adenylosuccinate lyase; Provisional; Region: PRK07492 1045858004124 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1045858004125 tetramer interface [polypeptide binding]; other site 1045858004126 active site 1045858004127 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1045858004128 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1045858004129 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1045858004130 tetramer interface [polypeptide binding]; other site 1045858004131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858004132 catalytic residue [active] 1045858004133 Cache domain; Region: Cache_1; pfam02743 1045858004134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858004135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858004136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858004137 dimer interface [polypeptide binding]; other site 1045858004138 putative CheW interface [polypeptide binding]; other site 1045858004139 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1045858004140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858004141 S-adenosylmethionine binding site [chemical binding]; other site 1045858004142 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1045858004143 NusA N-terminal domain; Region: NusA_N; pfam08529 1045858004144 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1045858004145 RNA binding site [nucleotide binding]; other site 1045858004146 homodimer interface [polypeptide binding]; other site 1045858004147 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1045858004148 G-X-X-G motif; other site 1045858004149 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1045858004150 G-X-X-G motif; other site 1045858004151 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1045858004152 Sm and related proteins; Region: Sm_like; cl00259 1045858004153 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1045858004154 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1045858004155 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1045858004156 putative active site [active] 1045858004157 catalytic site [active] 1045858004158 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1045858004159 putative active site [active] 1045858004160 catalytic site [active] 1045858004161 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1045858004162 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1045858004163 active site 1045858004164 catalytic triad [active] 1045858004165 dimer interface [polypeptide binding]; other site 1045858004166 Cache domain; Region: Cache_1; pfam02743 1045858004167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858004168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858004169 dimer interface [polypeptide binding]; other site 1045858004170 putative CheW interface [polypeptide binding]; other site 1045858004171 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1045858004172 galactokinase; Provisional; Region: PRK05101 1045858004173 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1045858004174 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045858004175 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1045858004176 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 1045858004177 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045858004178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858004179 S-adenosylmethionine binding site [chemical binding]; other site 1045858004180 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1045858004181 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1045858004182 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1045858004183 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1045858004184 substrate binding site [chemical binding]; other site 1045858004185 putative active site [active] 1045858004186 putative cosubstrate binding site; other site 1045858004187 catalytic site [active] 1045858004188 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1045858004189 substrate binding site [chemical binding]; other site 1045858004190 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1045858004191 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004192 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004193 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004194 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004195 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004196 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004197 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004198 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004199 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004200 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004201 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1045858004202 Predicted solute binding protein [General function prediction only]; Region: COG3889 1045858004203 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1045858004204 dimer interface [polypeptide binding]; other site 1045858004205 putative radical transfer pathway; other site 1045858004206 diiron center [ion binding]; other site 1045858004207 tyrosyl radical; other site 1045858004208 ATP cone domain; Region: ATP-cone; pfam03477 1045858004209 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1045858004210 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 1045858004211 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1045858004212 PBP superfamily domain; Region: PBP_like_2; cl17296 1045858004213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858004214 dimer interface [polypeptide binding]; other site 1045858004215 conserved gate region; other site 1045858004216 putative PBP binding loops; other site 1045858004217 ABC-ATPase subunit interface; other site 1045858004218 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1045858004219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858004220 dimer interface [polypeptide binding]; other site 1045858004221 conserved gate region; other site 1045858004222 putative PBP binding loops; other site 1045858004223 ABC-ATPase subunit interface; other site 1045858004224 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1045858004225 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1045858004226 Walker A/P-loop; other site 1045858004227 ATP binding site [chemical binding]; other site 1045858004228 Q-loop/lid; other site 1045858004229 ABC transporter signature motif; other site 1045858004230 Walker B; other site 1045858004231 D-loop; other site 1045858004232 H-loop/switch region; other site 1045858004233 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1045858004234 PhoU domain; Region: PhoU; pfam01895 1045858004235 PhoU domain; Region: PhoU; pfam01895 1045858004236 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1045858004237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858004238 Walker A/P-loop; other site 1045858004239 ATP binding site [chemical binding]; other site 1045858004240 Q-loop/lid; other site 1045858004241 ABC transporter signature motif; other site 1045858004242 Walker B; other site 1045858004243 D-loop; other site 1045858004244 H-loop/switch region; other site 1045858004245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045858004246 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1045858004247 TM-ABC transporter signature motif; other site 1045858004248 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1045858004249 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045858004250 zinc binding site [ion binding]; other site 1045858004251 putative ligand binding site [chemical binding]; other site 1045858004252 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1045858004253 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1045858004254 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1045858004255 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1045858004256 active site 1045858004257 NAD binding site [chemical binding]; other site 1045858004258 metal binding site [ion binding]; metal-binding site 1045858004259 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004260 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004261 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004262 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1045858004263 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1045858004264 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045858004265 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1045858004266 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1045858004267 Hexamer interface [polypeptide binding]; other site 1045858004268 Hexagonal pore residue; other site 1045858004269 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1045858004270 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1045858004271 putative hexamer interface [polypeptide binding]; other site 1045858004272 putative hexagonal pore; other site 1045858004273 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1045858004274 putative hexamer interface [polypeptide binding]; other site 1045858004275 putative hexagonal pore; other site 1045858004276 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1045858004277 Hexamer/Pentamer interface [polypeptide binding]; other site 1045858004278 central pore; other site 1045858004279 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1045858004280 SLBB domain; Region: SLBB; pfam10531 1045858004281 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1045858004282 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1045858004283 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1045858004284 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 1045858004285 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1045858004286 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1045858004287 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1045858004288 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1045858004289 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1045858004290 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1045858004291 Hexamer interface [polypeptide binding]; other site 1045858004292 Hexagonal pore residue; other site 1045858004293 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1045858004294 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1045858004295 Hexamer interface [polypeptide binding]; other site 1045858004296 Putative hexagonal pore residue; other site 1045858004297 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1045858004298 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1045858004299 Hexamer interface [polypeptide binding]; other site 1045858004300 Putative hexagonal pore residue; other site 1045858004301 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1045858004302 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1045858004303 Hexamer interface [polypeptide binding]; other site 1045858004304 Hexagonal pore residue; other site 1045858004305 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1045858004306 putative catalytic cysteine [active] 1045858004307 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1045858004308 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1045858004309 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1045858004310 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 1045858004311 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1045858004312 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1045858004313 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1045858004314 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1045858004315 alpha-beta subunit interface [polypeptide binding]; other site 1045858004316 alpha-gamma subunit interface [polypeptide binding]; other site 1045858004317 active site 1045858004318 substrate and K+ binding site; other site 1045858004319 K+ binding site [ion binding]; other site 1045858004320 cobalamin binding site [chemical binding]; other site 1045858004321 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 1045858004322 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1045858004323 putative hexamer interface [polypeptide binding]; other site 1045858004324 putative hexagonal pore; other site 1045858004325 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1045858004326 putative hexamer interface [polypeptide binding]; other site 1045858004327 putative hexagonal pore; other site 1045858004328 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1045858004329 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1045858004330 Walker A/P-loop; other site 1045858004331 ATP binding site [chemical binding]; other site 1045858004332 Q-loop/lid; other site 1045858004333 ABC transporter signature motif; other site 1045858004334 Walker B; other site 1045858004335 D-loop; other site 1045858004336 H-loop/switch region; other site 1045858004337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045858004338 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1045858004339 ABC-ATPase subunit interface; other site 1045858004340 dimer interface [polypeptide binding]; other site 1045858004341 putative PBP binding regions; other site 1045858004342 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1045858004343 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1045858004344 intersubunit interface [polypeptide binding]; other site 1045858004345 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1045858004346 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1045858004347 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1045858004348 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1045858004349 heterotetramer interface [polypeptide binding]; other site 1045858004350 active site pocket [active] 1045858004351 cleavage site 1045858004352 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1045858004353 feedback inhibition sensing region; other site 1045858004354 homohexameric interface [polypeptide binding]; other site 1045858004355 nucleotide binding site [chemical binding]; other site 1045858004356 N-acetyl-L-glutamate binding site [chemical binding]; other site 1045858004357 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045858004358 acetylornithine aminotransferase; Provisional; Region: PRK02627 1045858004359 inhibitor-cofactor binding pocket; inhibition site 1045858004360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858004361 catalytic residue [active] 1045858004362 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1045858004363 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045858004364 Walker A/P-loop; other site 1045858004365 ATP binding site [chemical binding]; other site 1045858004366 Q-loop/lid; other site 1045858004367 ABC transporter signature motif; other site 1045858004368 Walker B; other site 1045858004369 D-loop; other site 1045858004370 H-loop/switch region; other site 1045858004371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045858004372 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1045858004373 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1045858004374 FMN binding site [chemical binding]; other site 1045858004375 active site 1045858004376 catalytic residues [active] 1045858004377 substrate binding site [chemical binding]; other site 1045858004378 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1045858004379 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1045858004380 Walker A/P-loop; other site 1045858004381 ATP binding site [chemical binding]; other site 1045858004382 Q-loop/lid; other site 1045858004383 ABC transporter signature motif; other site 1045858004384 Walker B; other site 1045858004385 D-loop; other site 1045858004386 H-loop/switch region; other site 1045858004387 TOBE domain; Region: TOBE; pfam03459 1045858004388 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1045858004389 active site turn [active] 1045858004390 phosphorylation site [posttranslational modification] 1045858004391 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858004392 active site turn [active] 1045858004393 phosphorylation site [posttranslational modification] 1045858004394 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858004395 active site turn [active] 1045858004396 phosphorylation site [posttranslational modification] 1045858004397 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858004398 active site turn [active] 1045858004399 phosphorylation site [posttranslational modification] 1045858004400 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1045858004401 active site turn [active] 1045858004402 phosphorylation site [posttranslational modification] 1045858004403 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1045858004404 active site turn [active] 1045858004405 phosphorylation site [posttranslational modification] 1045858004406 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1045858004407 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045858004408 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858004409 active site turn [active] 1045858004410 phosphorylation site [posttranslational modification] 1045858004411 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1045858004412 HPr interaction site; other site 1045858004413 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045858004414 active site 1045858004415 phosphorylation site [posttranslational modification] 1045858004416 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1045858004417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858004418 active site 1045858004419 phosphorylation site [posttranslational modification] 1045858004420 intermolecular recognition site; other site 1045858004421 dimerization interface [polypeptide binding]; other site 1045858004422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858004423 Walker A motif; other site 1045858004424 ATP binding site [chemical binding]; other site 1045858004425 Walker B motif; other site 1045858004426 arginine finger; other site 1045858004427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1045858004428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1045858004429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1045858004430 dimer interface [polypeptide binding]; other site 1045858004431 phosphorylation site [posttranslational modification] 1045858004432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858004433 ATP binding site [chemical binding]; other site 1045858004434 Mg2+ binding site [ion binding]; other site 1045858004435 G-X-G motif; other site 1045858004436 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1045858004437 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1045858004438 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1045858004439 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1045858004440 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1045858004441 active site 1045858004442 catalytic residues [active] 1045858004443 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1045858004444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858004445 active site 1045858004446 motif I; other site 1045858004447 motif II; other site 1045858004448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858004449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858004450 putative substrate translocation pore; other site 1045858004451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045858004452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1045858004453 EamA-like transporter family; Region: EamA; pfam00892 1045858004454 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1045858004455 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1045858004456 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1045858004457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1045858004458 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1045858004459 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1045858004460 oligomer interface [polypeptide binding]; other site 1045858004461 active site 1045858004462 metal binding site [ion binding]; metal-binding site 1045858004463 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1045858004464 Asp-box motif; other site 1045858004465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858004466 binding surface 1045858004467 TPR repeat; Region: TPR_11; pfam13414 1045858004468 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 1045858004469 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1045858004470 minor groove reading motif; other site 1045858004471 helix-hairpin-helix signature motif; other site 1045858004472 active site 1045858004473 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1045858004474 active site 1045858004475 metal binding site [ion binding]; metal-binding site 1045858004476 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1045858004477 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1045858004478 LabA_like proteins; Region: LabA_like; cd06167 1045858004479 putative metal binding site [ion binding]; other site 1045858004480 prephenate dehydrogenase; Validated; Region: PRK08507 1045858004481 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1045858004482 TM2 domain; Region: TM2; pfam05154 1045858004483 homoserine kinase; Provisional; Region: PRK01212 1045858004484 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1045858004485 threonine synthase; Reviewed; Region: PRK06721 1045858004486 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1045858004487 homodimer interface [polypeptide binding]; other site 1045858004488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858004489 catalytic residue [active] 1045858004490 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1045858004491 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1045858004492 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1045858004493 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1045858004494 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1045858004495 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1045858004496 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1045858004497 RNA binding site [nucleotide binding]; other site 1045858004498 active site 1045858004499 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1045858004500 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1045858004501 trimer interface [polypeptide binding]; other site 1045858004502 active site 1045858004503 dimer interface [polypeptide binding]; other site 1045858004504 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1045858004505 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1045858004506 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1045858004507 active site 1045858004508 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045858004509 ligand binding site [chemical binding]; other site 1045858004510 Flavodoxin domain; Region: Flavodoxin_5; cl17428 1045858004511 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1045858004512 GTP1/OBG; Region: GTP1_OBG; pfam01018 1045858004513 Obg GTPase; Region: Obg; cd01898 1045858004514 G1 box; other site 1045858004515 GTP/Mg2+ binding site [chemical binding]; other site 1045858004516 Switch I region; other site 1045858004517 G2 box; other site 1045858004518 G3 box; other site 1045858004519 Switch II region; other site 1045858004520 G4 box; other site 1045858004521 G5 box; other site 1045858004522 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 1045858004523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858004524 FeS/SAM binding site; other site 1045858004525 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045858004526 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045858004527 ligand binding site [chemical binding]; other site 1045858004528 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1045858004529 dimerization interface [polypeptide binding]; other site 1045858004530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858004531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858004532 dimer interface [polypeptide binding]; other site 1045858004533 putative CheW interface [polypeptide binding]; other site 1045858004534 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1045858004535 dimerization interface [polypeptide binding]; other site 1045858004536 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858004537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858004538 dimer interface [polypeptide binding]; other site 1045858004539 putative CheW interface [polypeptide binding]; other site 1045858004540 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1045858004541 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045858004542 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1045858004543 alpha subunit interaction interface [polypeptide binding]; other site 1045858004544 Walker A motif; other site 1045858004545 ATP binding site [chemical binding]; other site 1045858004546 Walker B motif; other site 1045858004547 inhibitor binding site; inhibition site 1045858004548 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1045858004549 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1045858004550 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1045858004551 active site 1045858004552 dimerization interface [polypeptide binding]; other site 1045858004553 mce related protein; Region: MCE; pfam02470 1045858004554 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1045858004555 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1045858004556 Walker A/P-loop; other site 1045858004557 ATP binding site [chemical binding]; other site 1045858004558 Q-loop/lid; other site 1045858004559 ABC transporter signature motif; other site 1045858004560 Walker B; other site 1045858004561 D-loop; other site 1045858004562 H-loop/switch region; other site 1045858004563 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1045858004564 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1045858004565 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1045858004566 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1045858004567 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1045858004568 hinge region; other site 1045858004569 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1045858004570 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1045858004571 catalytic residue [active] 1045858004572 putative FPP diphosphate binding site; other site 1045858004573 putative FPP binding hydrophobic cleft; other site 1045858004574 dimer interface [polypeptide binding]; other site 1045858004575 putative IPP diphosphate binding site; other site 1045858004576 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1045858004577 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1045858004578 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1045858004579 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1045858004580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858004581 dimer interface [polypeptide binding]; other site 1045858004582 conserved gate region; other site 1045858004583 putative PBP binding loops; other site 1045858004584 ABC-ATPase subunit interface; other site 1045858004585 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1045858004586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858004587 dimer interface [polypeptide binding]; other site 1045858004588 conserved gate region; other site 1045858004589 putative PBP binding loops; other site 1045858004590 ABC-ATPase subunit interface; other site 1045858004591 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1045858004592 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1045858004593 active site 1045858004594 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045858004595 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1045858004596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045858004597 ABC transporter; Region: ABC_tran_2; pfam12848 1045858004598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1045858004599 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1045858004600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045858004601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045858004602 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1045858004603 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1045858004604 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1045858004605 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1045858004606 peroxiredoxin; Region: AhpC; TIGR03137 1045858004607 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1045858004608 dimer interface [polypeptide binding]; other site 1045858004609 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1045858004610 catalytic triad [active] 1045858004611 peroxidatic and resolving cysteines [active] 1045858004612 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1045858004613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858004614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858004615 homodimer interface [polypeptide binding]; other site 1045858004616 catalytic residue [active] 1045858004617 hypothetical protein; Provisional; Region: PRK13665 1045858004618 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1045858004619 putative nucleotide binding site [chemical binding]; other site 1045858004620 uridine monophosphate binding site [chemical binding]; other site 1045858004621 homohexameric interface [polypeptide binding]; other site 1045858004622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858004623 Coenzyme A binding pocket [chemical binding]; other site 1045858004624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858004625 Coenzyme A binding pocket [chemical binding]; other site 1045858004626 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1045858004627 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1045858004628 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1045858004629 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858004630 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858004631 peptide binding site [polypeptide binding]; other site 1045858004632 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1045858004633 propionate/acetate kinase; Provisional; Region: PRK12379 1045858004634 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858004635 Peptidase M30; Region: Peptidase_M30; pfam10460 1045858004636 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1045858004637 Filamin-type immunoglobulin domains; Region: IG_FLMN; smart00557 1045858004638 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1045858004639 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1045858004640 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1045858004641 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1045858004642 NAD binding site [chemical binding]; other site 1045858004643 substrate binding site [chemical binding]; other site 1045858004644 homodimer interface [polypeptide binding]; other site 1045858004645 active site 1045858004646 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1045858004647 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1045858004648 NADP binding site [chemical binding]; other site 1045858004649 active site 1045858004650 putative substrate binding site [chemical binding]; other site 1045858004651 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1045858004652 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045858004653 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1045858004654 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1045858004655 Walker A/P-loop; other site 1045858004656 ATP binding site [chemical binding]; other site 1045858004657 Q-loop/lid; other site 1045858004658 ABC transporter signature motif; other site 1045858004659 Walker B; other site 1045858004660 D-loop; other site 1045858004661 H-loop/switch region; other site 1045858004662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045858004663 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045858004664 Walker A/P-loop; other site 1045858004665 ATP binding site [chemical binding]; other site 1045858004666 Q-loop/lid; other site 1045858004667 ABC transporter signature motif; other site 1045858004668 Walker B; other site 1045858004669 D-loop; other site 1045858004670 H-loop/switch region; other site 1045858004671 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1045858004672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045858004673 TPR repeat; Region: TPR_11; pfam13414 1045858004674 TPR repeat; Region: TPR_11; pfam13414 1045858004675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858004676 binding surface 1045858004677 TPR motif; other site 1045858004678 TPR repeat; Region: TPR_11; pfam13414 1045858004679 TPR repeat; Region: TPR_11; pfam13414 1045858004680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858004681 binding surface 1045858004682 TPR motif; other site 1045858004683 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858004684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858004685 binding surface 1045858004686 TPR motif; other site 1045858004687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858004688 binding surface 1045858004689 TPR motif; other site 1045858004690 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1045858004691 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1045858004692 folate binding site [chemical binding]; other site 1045858004693 NADP+ binding site [chemical binding]; other site 1045858004694 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1045858004695 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1045858004696 dimerization interface [polypeptide binding]; other site 1045858004697 active site 1045858004698 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1045858004699 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1045858004700 Cache domain; Region: Cache_1; pfam02743 1045858004701 HAMP domain; Region: HAMP; pfam00672 1045858004702 dimerization interface [polypeptide binding]; other site 1045858004703 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858004704 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858004705 dimer interface [polypeptide binding]; other site 1045858004706 putative CheW interface [polypeptide binding]; other site 1045858004707 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858004708 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1045858004709 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1045858004710 ring oligomerisation interface [polypeptide binding]; other site 1045858004711 ATP/Mg binding site [chemical binding]; other site 1045858004712 stacking interactions; other site 1045858004713 hinge regions; other site 1045858004714 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1045858004715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045858004716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045858004717 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1045858004718 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1045858004719 Competence protein; Region: Competence; pfam03772 1045858004720 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1045858004721 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1045858004722 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1045858004723 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1045858004724 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045858004725 active site 1045858004726 HIGH motif; other site 1045858004727 nucleotide binding site [chemical binding]; other site 1045858004728 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1045858004729 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1045858004730 active site 1045858004731 KMSKS motif; other site 1045858004732 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1045858004733 tRNA binding surface [nucleotide binding]; other site 1045858004734 anticodon binding site; other site 1045858004735 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1045858004736 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858004737 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1045858004738 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1045858004739 metal binding site [ion binding]; metal-binding site 1045858004740 dimer interface [polypeptide binding]; other site 1045858004741 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1045858004742 Rrf2 family protein; Region: rrf2_super; TIGR00738 1045858004743 Transcriptional regulator; Region: Rrf2; pfam02082 1045858004744 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1045858004745 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1045858004746 catalytic residue [active] 1045858004747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858004748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858004749 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 1045858004750 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1045858004751 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1045858004752 NADP-binding site; other site 1045858004753 homotetramer interface [polypeptide binding]; other site 1045858004754 substrate binding site [chemical binding]; other site 1045858004755 homodimer interface [polypeptide binding]; other site 1045858004756 active site 1045858004757 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1045858004758 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1045858004759 NADP binding site [chemical binding]; other site 1045858004760 active site 1045858004761 putative substrate binding site [chemical binding]; other site 1045858004762 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1045858004763 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1045858004764 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1045858004765 PhoU domain; Region: PhoU; pfam01895 1045858004766 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045858004767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858004768 Coenzyme A binding pocket [chemical binding]; other site 1045858004769 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004770 glutamate dehydrogenase; Provisional; Region: PRK09414 1045858004771 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1045858004772 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1045858004773 NAD(P) binding site [chemical binding]; other site 1045858004774 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1045858004775 TPR repeat; Region: TPR_11; pfam13414 1045858004776 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858004777 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1045858004778 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858004779 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004780 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004781 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004782 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004783 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1045858004784 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1045858004785 active site 1045858004786 FMN binding site [chemical binding]; other site 1045858004787 substrate binding site [chemical binding]; other site 1045858004788 homotetramer interface [polypeptide binding]; other site 1045858004789 catalytic residue [active] 1045858004790 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004791 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004792 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004793 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004794 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004795 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004796 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004797 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004798 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004799 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004800 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004801 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004802 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004803 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004804 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004805 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004806 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004807 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004808 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1045858004809 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1045858004810 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1045858004811 active site 1045858004812 HIGH motif; other site 1045858004813 dimer interface [polypeptide binding]; other site 1045858004814 KMSKS motif; other site 1045858004815 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1045858004816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858004817 Mg2+ binding site [ion binding]; other site 1045858004818 G-X-G motif; other site 1045858004819 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1045858004820 anchoring element; other site 1045858004821 dimer interface [polypeptide binding]; other site 1045858004822 ATP binding site [chemical binding]; other site 1045858004823 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1045858004824 active site 1045858004825 putative metal-binding site [ion binding]; other site 1045858004826 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1045858004827 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1045858004828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045858004829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858004830 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1045858004831 active site 1045858004832 P-loop; other site 1045858004833 phosphorylation site [posttranslational modification] 1045858004834 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1045858004835 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1045858004836 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1045858004837 active site 1045858004838 (T/H)XGH motif; other site 1045858004839 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1045858004840 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1045858004841 active site 1045858004842 metal binding site [ion binding]; metal-binding site 1045858004843 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045858004844 oligoendopeptidase F; Region: pepF; TIGR00181 1045858004845 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1045858004846 active site 1045858004847 Zn binding site [ion binding]; other site 1045858004848 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1045858004849 23S rRNA binding site [nucleotide binding]; other site 1045858004850 L21 binding site [polypeptide binding]; other site 1045858004851 L13 binding site [polypeptide binding]; other site 1045858004852 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1045858004853 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1045858004854 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1045858004855 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1045858004856 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1045858004857 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1045858004858 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1045858004859 active site 1045858004860 dimer interface [polypeptide binding]; other site 1045858004861 motif 1; other site 1045858004862 motif 2; other site 1045858004863 motif 3; other site 1045858004864 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1045858004865 anticodon binding site; other site 1045858004866 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1045858004867 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1045858004868 intersubunit interface [polypeptide binding]; other site 1045858004869 active site 1045858004870 zinc binding site [ion binding]; other site 1045858004871 Na+ binding site [ion binding]; other site 1045858004872 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1045858004873 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1045858004874 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004875 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004876 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858004877 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858004878 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 1045858004879 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1045858004880 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1045858004881 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1045858004882 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1045858004883 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1045858004884 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1045858004885 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1045858004886 TPR repeat; Region: TPR_11; pfam13414 1045858004887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858004888 binding surface 1045858004889 TPR motif; other site 1045858004890 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045858004891 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1045858004892 substrate binding site [chemical binding]; other site 1045858004893 ATP binding site [chemical binding]; other site 1045858004894 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1045858004895 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045858004896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045858004897 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1045858004898 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858004899 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858004900 peptide binding site [polypeptide binding]; other site 1045858004901 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1045858004902 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1045858004903 NAD binding site [chemical binding]; other site 1045858004904 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858004905 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1045858004906 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1045858004907 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1045858004908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858004909 ATP binding site [chemical binding]; other site 1045858004910 putative Mg++ binding site [ion binding]; other site 1045858004911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045858004912 nucleotide binding region [chemical binding]; other site 1045858004913 ATP-binding site [chemical binding]; other site 1045858004914 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858004915 active site turn [active] 1045858004916 phosphorylation site [posttranslational modification] 1045858004917 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004918 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004919 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004920 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004921 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004922 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1045858004923 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858004924 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004925 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004926 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858004927 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004928 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004929 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858004930 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004931 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1045858004932 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004933 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858004934 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004935 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1045858004936 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004937 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858004938 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858004939 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1045858004940 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1045858004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858004942 S-adenosylmethionine binding site [chemical binding]; other site 1045858004943 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1045858004944 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1045858004945 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1045858004946 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1045858004947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858004948 ATP binding site [chemical binding]; other site 1045858004949 putative Mg++ binding site [ion binding]; other site 1045858004950 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1045858004951 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858004952 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1045858004953 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045858004954 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045858004955 DNA binding site [nucleotide binding] 1045858004956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045858004957 ligand binding site [chemical binding]; other site 1045858004958 dimerization interface [polypeptide binding]; other site 1045858004959 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1045858004960 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1045858004961 N- and C-terminal domain interface [polypeptide binding]; other site 1045858004962 active site 1045858004963 MgATP binding site [chemical binding]; other site 1045858004964 catalytic site [active] 1045858004965 metal binding site [ion binding]; metal-binding site 1045858004966 carbohydrate binding site [chemical binding]; other site 1045858004967 putative homodimer interface [polypeptide binding]; other site 1045858004968 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1045858004969 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1045858004970 dimer interface [polypeptide binding]; other site 1045858004971 active site 1045858004972 metal binding site [ion binding]; metal-binding site 1045858004973 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1045858004974 intersubunit interface [polypeptide binding]; other site 1045858004975 active site 1045858004976 Zn2+ binding site [ion binding]; other site 1045858004977 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1045858004978 N- and C-terminal domain interface [polypeptide binding]; other site 1045858004979 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1045858004980 active site 1045858004981 putative catalytic site [active] 1045858004982 metal binding site [ion binding]; metal-binding site 1045858004983 ATP binding site [chemical binding]; other site 1045858004984 carbohydrate binding site [chemical binding]; other site 1045858004985 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1045858004986 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1045858004987 Walker A/P-loop; other site 1045858004988 ATP binding site [chemical binding]; other site 1045858004989 Q-loop/lid; other site 1045858004990 ABC transporter signature motif; other site 1045858004991 Walker B; other site 1045858004992 D-loop; other site 1045858004993 H-loop/switch region; other site 1045858004994 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1045858004995 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1045858004996 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1045858004997 TM-ABC transporter signature motif; other site 1045858004998 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1045858004999 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1045858005000 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1045858005001 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1045858005002 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1045858005003 trimer interface [polypeptide binding]; other site 1045858005004 substrate binding site [chemical binding]; other site 1045858005005 Mn binding site [ion binding]; other site 1045858005006 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 1045858005007 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1045858005008 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1045858005009 TPR repeat; Region: TPR_11; pfam13414 1045858005010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005011 binding surface 1045858005012 TPR motif; other site 1045858005013 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1045858005014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005015 binding surface 1045858005016 TPR motif; other site 1045858005017 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858005018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005019 binding surface 1045858005020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858005021 TPR motif; other site 1045858005022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005023 TPR motif; other site 1045858005024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858005025 binding surface 1045858005026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858005027 binding surface 1045858005028 TPR motif; other site 1045858005029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005030 binding surface 1045858005031 TPR motif; other site 1045858005032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858005033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005034 TPR motif; other site 1045858005035 TPR repeat; Region: TPR_11; pfam13414 1045858005036 binding surface 1045858005037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858005038 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858005039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005040 binding surface 1045858005041 TPR motif; other site 1045858005042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858005043 TPR motif; other site 1045858005044 binding surface 1045858005045 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1045858005046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005047 TPR motif; other site 1045858005048 binding surface 1045858005049 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1045858005050 FMN-binding domain; Region: FMN_bind; cl01081 1045858005051 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1045858005052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1045858005053 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1045858005054 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1045858005055 tandem repeat interface [polypeptide binding]; other site 1045858005056 oligomer interface [polypeptide binding]; other site 1045858005057 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1045858005058 active site residues [active] 1045858005059 Predicted permeases [General function prediction only]; Region: COG0795 1045858005060 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1045858005061 mitochondrial import inner membrane, translocase subunit; Region: 3a0801s03tim44; TIGR00984 1045858005062 TPR repeat; Region: TPR_11; pfam13414 1045858005063 TPR repeat; Region: TPR_11; pfam13414 1045858005064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005065 binding surface 1045858005066 TPR motif; other site 1045858005067 TPR repeat; Region: TPR_11; pfam13414 1045858005068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005069 binding surface 1045858005070 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858005071 TPR motif; other site 1045858005072 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1045858005073 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1045858005074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858005075 catalytic residue [active] 1045858005076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858005077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1045858005078 putative substrate translocation pore; other site 1045858005079 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1045858005080 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045858005081 Catalytic site [active] 1045858005082 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045858005083 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1045858005084 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1045858005085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1045858005086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1045858005087 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1045858005088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045858005089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858005090 active site 1045858005091 phosphorylation site [posttranslational modification] 1045858005092 intermolecular recognition site; other site 1045858005093 dimerization interface [polypeptide binding]; other site 1045858005094 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1045858005095 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1045858005096 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1045858005097 MgtE intracellular N domain; Region: MgtE_N; cl15244 1045858005098 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1045858005099 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1045858005100 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1045858005101 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1045858005102 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1045858005103 B12 binding site [chemical binding]; other site 1045858005104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858005105 FeS/SAM binding site; other site 1045858005106 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1045858005107 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1045858005108 Ferritin-like domain; Region: Ferritin; pfam00210 1045858005109 ferroxidase diiron center [ion binding]; other site 1045858005110 Cache domain; Region: Cache_1; pfam02743 1045858005111 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005113 dimer interface [polypeptide binding]; other site 1045858005114 putative CheW interface [polypeptide binding]; other site 1045858005115 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1045858005116 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1045858005117 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1045858005118 putative active site [active] 1045858005119 metal binding site [ion binding]; metal-binding site 1045858005120 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1045858005121 Sodium Bile acid symporter family; Region: SBF; pfam01758 1045858005122 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1045858005123 substrate binding site [chemical binding]; other site 1045858005124 multimerization interface [polypeptide binding]; other site 1045858005125 ATP binding site [chemical binding]; other site 1045858005126 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1045858005127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1045858005128 Nucleoside recognition; Region: Gate; pfam07670 1045858005129 Helix-turn-helix domain; Region: HTH_36; pfam13730 1045858005130 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858005131 Sulfatase; Region: Sulfatase; pfam00884 1045858005132 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1045858005133 Sulfatase; Region: Sulfatase; cl17466 1045858005134 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1045858005135 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1045858005136 Walker A/P-loop; other site 1045858005137 ATP binding site [chemical binding]; other site 1045858005138 Q-loop/lid; other site 1045858005139 ABC transporter signature motif; other site 1045858005140 Walker B; other site 1045858005141 D-loop; other site 1045858005142 H-loop/switch region; other site 1045858005143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858005144 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1045858005145 ABC transporter signature motif; other site 1045858005146 Walker B; other site 1045858005147 D-loop; other site 1045858005148 H-loop/switch region; other site 1045858005149 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045858005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858005151 dimer interface [polypeptide binding]; other site 1045858005152 ABC-ATPase subunit interface; other site 1045858005153 putative PBP binding loops; other site 1045858005154 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1045858005155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858005156 dimer interface [polypeptide binding]; other site 1045858005157 conserved gate region; other site 1045858005158 putative PBP binding loops; other site 1045858005159 ABC-ATPase subunit interface; other site 1045858005160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1045858005161 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1045858005162 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1045858005163 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1045858005164 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1045858005165 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1045858005166 GIY-YIG motif/motif A; other site 1045858005167 active site 1045858005168 catalytic site [active] 1045858005169 putative DNA binding site [nucleotide binding]; other site 1045858005170 metal binding site [ion binding]; metal-binding site 1045858005171 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1045858005172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858005173 active site 1045858005174 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1045858005175 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1045858005176 putative tRNA-binding site [nucleotide binding]; other site 1045858005177 B3/4 domain; Region: B3_4; pfam03483 1045858005178 tRNA synthetase B5 domain; Region: B5; pfam03484 1045858005179 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1045858005180 dimer interface [polypeptide binding]; other site 1045858005181 motif 1; other site 1045858005182 motif 3; other site 1045858005183 motif 2; other site 1045858005184 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1045858005185 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1045858005186 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1045858005187 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1045858005188 dimer interface [polypeptide binding]; other site 1045858005189 motif 1; other site 1045858005190 active site 1045858005191 motif 2; other site 1045858005192 motif 3; other site 1045858005193 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858005194 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1045858005195 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1045858005196 Protein of unknown function DUF58; Region: DUF58; pfam01882 1045858005197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1045858005198 metal ion-dependent adhesion site (MIDAS); other site 1045858005199 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005200 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005201 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005202 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005203 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005204 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005205 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045858005208 transcriptional regulator SlyA; Provisional; Region: PRK03573 1045858005209 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1045858005210 heme-binding site [chemical binding]; other site 1045858005211 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1045858005212 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1045858005213 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1045858005214 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1045858005215 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1045858005216 substrate binding site [chemical binding]; other site 1045858005217 oxyanion hole (OAH) forming residues; other site 1045858005218 trimer interface [polypeptide binding]; other site 1045858005219 putative acyltransferase; Provisional; Region: PRK05790 1045858005220 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045858005221 dimer interface [polypeptide binding]; other site 1045858005222 active site 1045858005223 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1045858005224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1045858005225 ATP binding site [chemical binding]; other site 1045858005226 Mg2+ binding site [ion binding]; other site 1045858005227 G-X-G motif; other site 1045858005228 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1045858005229 ATP binding site [chemical binding]; other site 1045858005230 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1045858005231 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858005232 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005233 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005234 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005235 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005236 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005237 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005238 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005239 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005240 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1045858005241 Fe-S cluster binding site [ion binding]; other site 1045858005242 active site 1045858005243 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005244 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005245 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005246 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858005247 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1045858005248 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1045858005249 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1045858005250 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1045858005251 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1045858005252 30S subunit binding site; other site 1045858005253 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858005254 active site 1045858005255 phosphorylation site [posttranslational modification] 1045858005256 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1045858005257 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1045858005258 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1045858005259 Hpr binding site; other site 1045858005260 active site 1045858005261 homohexamer subunit interaction site [polypeptide binding]; other site 1045858005262 MraW methylase family; Region: Methyltransf_5; cl17771 1045858005263 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1045858005264 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1045858005265 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045858005266 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045858005267 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1045858005268 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045858005269 PYR/PP interface [polypeptide binding]; other site 1045858005270 dimer interface [polypeptide binding]; other site 1045858005271 TPP binding site [chemical binding]; other site 1045858005272 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045858005273 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1045858005274 transketolase; Reviewed; Region: PRK05899 1045858005275 TPP-binding site [chemical binding]; other site 1045858005276 dimer interface [polypeptide binding]; other site 1045858005277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858005278 active site 1045858005279 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1045858005280 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1045858005281 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1045858005282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858005283 Coenzyme A binding pocket [chemical binding]; other site 1045858005284 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045858005285 Coenzyme A binding pocket [chemical binding]; other site 1045858005286 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1045858005287 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1045858005288 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1045858005289 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1045858005290 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858005291 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 1045858005292 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1045858005293 ligand binding site; other site 1045858005294 oligomer interface; other site 1045858005295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858005296 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1045858005297 dimer interface [polypeptide binding]; other site 1045858005298 N-terminal domain interface [polypeptide binding]; other site 1045858005299 sulfate 1 binding site; other site 1045858005300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858005301 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1045858005302 active site 1045858005303 motif I; other site 1045858005304 motif II; other site 1045858005305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1045858005306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858005307 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1045858005308 active site 1045858005309 motif I; other site 1045858005310 motif II; other site 1045858005311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1045858005312 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1045858005313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858005314 active site 1045858005315 motif I; other site 1045858005316 motif II; other site 1045858005317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858005318 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1045858005319 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1045858005320 conserved cys residue [active] 1045858005321 glycogen synthase; Provisional; Region: glgA; PRK00654 1045858005322 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1045858005323 ADP-binding pocket [chemical binding]; other site 1045858005324 homodimer interface [polypeptide binding]; other site 1045858005325 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1045858005326 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1045858005327 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1045858005328 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1045858005329 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1045858005330 substrate binding [chemical binding]; other site 1045858005331 active site 1045858005332 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1045858005333 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1045858005334 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858005335 active site turn [active] 1045858005336 phosphorylation site [posttranslational modification] 1045858005337 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045858005338 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045858005339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1045858005340 DNA binding site [nucleotide binding] 1045858005341 domain linker motif; other site 1045858005342 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1045858005343 dimerization interface [polypeptide binding]; other site 1045858005344 ligand binding site [chemical binding]; other site 1045858005345 phenylhydantoinase; Validated; Region: PRK08323 1045858005346 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1045858005347 tetramer interface [polypeptide binding]; other site 1045858005348 active site 1045858005349 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858005350 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1045858005351 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005352 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005353 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005354 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005355 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005356 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005357 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005358 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005359 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005360 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005361 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005362 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005363 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005364 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1045858005365 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1045858005366 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 1045858005367 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1045858005368 catalytic loop [active] 1045858005369 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1045858005370 iron binding site [ion binding]; other site 1045858005371 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1045858005372 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1045858005373 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1045858005374 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1045858005375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045858005376 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1045858005377 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045858005378 active site 1045858005379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1045858005380 YheO-like PAS domain; Region: PAS_6; pfam08348 1045858005381 HTH domain; Region: HTH_22; pfam13309 1045858005382 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1045858005383 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1045858005384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858005385 catalytic residue [active] 1045858005386 peptidase; Reviewed; Region: PRK13004 1045858005387 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1045858005388 putative metal binding site [ion binding]; other site 1045858005389 putative dimer interface [polypeptide binding]; other site 1045858005390 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1045858005391 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045858005392 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045858005393 carbamate kinase; Reviewed; Region: PRK12686 1045858005394 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1045858005395 putative substrate binding site [chemical binding]; other site 1045858005396 nucleotide binding site [chemical binding]; other site 1045858005397 nucleotide binding site [chemical binding]; other site 1045858005398 homodimer interface [polypeptide binding]; other site 1045858005399 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1045858005400 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1045858005401 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1045858005402 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1045858005403 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1045858005404 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1045858005405 xanthine permease; Region: pbuX; TIGR03173 1045858005406 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1045858005407 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1045858005408 Ligand binding site; other site 1045858005409 metal-binding site 1045858005410 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1045858005411 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1045858005412 biotin synthase; Provisional; Region: PRK07094 1045858005413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858005414 FeS/SAM binding site; other site 1045858005415 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1045858005416 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1045858005417 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1045858005418 G1 box; other site 1045858005419 GTP/Mg2+ binding site [chemical binding]; other site 1045858005420 Switch I region; other site 1045858005421 G2 box; other site 1045858005422 Switch II region; other site 1045858005423 G3 box; other site 1045858005424 G4 box; other site 1045858005425 G5 box; other site 1045858005426 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1045858005427 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 1045858005428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858005429 FeS/SAM binding site; other site 1045858005430 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1045858005431 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 1045858005432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858005433 dimerization interface [polypeptide binding]; other site 1045858005434 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005436 dimer interface [polypeptide binding]; other site 1045858005437 putative CheW interface [polypeptide binding]; other site 1045858005438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858005439 dimerization interface [polypeptide binding]; other site 1045858005440 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005442 dimer interface [polypeptide binding]; other site 1045858005443 putative CheW interface [polypeptide binding]; other site 1045858005444 Cache domain; Region: Cache_1; pfam02743 1045858005445 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005446 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005447 dimer interface [polypeptide binding]; other site 1045858005448 putative CheW interface [polypeptide binding]; other site 1045858005449 Transglycosylase; Region: Transgly; pfam00912 1045858005450 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1045858005451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1045858005452 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1045858005453 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1045858005454 TPP-binding site; other site 1045858005455 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1045858005456 PYR/PP interface [polypeptide binding]; other site 1045858005457 dimer interface [polypeptide binding]; other site 1045858005458 TPP binding site [chemical binding]; other site 1045858005459 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1045858005460 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1045858005461 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045858005462 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045858005463 dihydroorotase; Provisional; Region: PRK07575 1045858005464 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045858005465 active site 1045858005466 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1045858005467 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1045858005468 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1045858005469 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1045858005470 ABC-ATPase subunit interface; other site 1045858005471 dimer interface [polypeptide binding]; other site 1045858005472 putative PBP binding regions; other site 1045858005473 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1045858005474 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1045858005475 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1045858005476 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1045858005477 intersubunit interface [polypeptide binding]; other site 1045858005478 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1045858005479 Winged helix-turn helix; Region: HTH_29; pfam13551 1045858005480 Homeodomain-like domain; Region: HTH_23; pfam13384 1045858005481 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1045858005482 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1045858005483 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1045858005484 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1045858005485 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1045858005486 inhibitor-cofactor binding pocket; inhibition site 1045858005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858005488 catalytic residue [active] 1045858005489 hypothetical protein; Provisional; Region: PRK10621 1045858005490 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1045858005491 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1045858005492 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1045858005493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858005494 active site 1045858005495 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1045858005496 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1045858005497 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 1045858005498 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045858005499 FliW protein; Region: FliW; cl00740 1045858005500 Global regulator protein family; Region: CsrA; pfam02599 1045858005501 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1045858005502 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858005503 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1045858005504 CoenzymeA binding site [chemical binding]; other site 1045858005505 subunit interaction site [polypeptide binding]; other site 1045858005506 PHB binding site; other site 1045858005507 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1045858005508 Na2 binding site [ion binding]; other site 1045858005509 putative substrate binding site 1 [chemical binding]; other site 1045858005510 Na binding site 1 [ion binding]; other site 1045858005511 putative substrate binding site 2 [chemical binding]; other site 1045858005512 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1045858005513 active site 1045858005514 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1045858005515 Domain of unknown function DUF21; Region: DUF21; pfam01595 1045858005516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1045858005517 Transporter associated domain; Region: CorC_HlyC; smart01091 1045858005518 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1045858005519 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1045858005520 Ligand Binding Site [chemical binding]; other site 1045858005521 Sporulation related domain; Region: SPOR; pfam05036 1045858005522 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1045858005523 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1045858005524 CoA-binding site [chemical binding]; other site 1045858005525 ATP-binding [chemical binding]; other site 1045858005526 Tetratricopeptide repeat; Region: TPR_15; pfam13429 1045858005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005528 binding surface 1045858005529 TPR motif; other site 1045858005530 cell division protein FtsZ; Region: ftsZ; TIGR00065 1045858005531 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1045858005532 nucleotide binding site [chemical binding]; other site 1045858005533 SulA interaction site; other site 1045858005534 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1045858005535 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1045858005536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858005537 FeS/SAM binding site; other site 1045858005538 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1045858005539 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858005540 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858005541 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858005542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005543 binding surface 1045858005544 TPR repeat; Region: TPR_11; pfam13414 1045858005545 TPR motif; other site 1045858005546 TPR repeat; Region: TPR_11; pfam13414 1045858005547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005548 binding surface 1045858005549 TPR motif; other site 1045858005550 TPR repeat; Region: TPR_11; pfam13414 1045858005551 TPR repeat; Region: TPR_11; pfam13414 1045858005552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005553 binding surface 1045858005554 TPR motif; other site 1045858005555 TPR repeat; Region: TPR_11; pfam13414 1045858005556 TPR repeat; Region: TPR_11; pfam13414 1045858005557 TPR repeat; Region: TPR_11; pfam13414 1045858005558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005559 binding surface 1045858005560 TPR motif; other site 1045858005561 TPR repeat; Region: TPR_11; pfam13414 1045858005562 TPR repeat; Region: TPR_11; pfam13414 1045858005563 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1045858005564 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1045858005565 L-aspartate oxidase; Provisional; Region: PRK06175 1045858005566 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1045858005567 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1045858005568 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858005569 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045858005570 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1045858005571 4Fe-4S binding domain; Region: Fer4; pfam00037 1045858005572 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1045858005573 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1045858005574 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1045858005575 Cache domain; Region: Cache_1; pfam02743 1045858005576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1045858005577 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005579 dimer interface [polypeptide binding]; other site 1045858005580 putative CheW interface [polypeptide binding]; other site 1045858005581 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005582 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005583 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005584 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005585 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005586 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005587 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005588 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005589 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005590 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005591 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005592 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005593 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1045858005594 flagellin; Provisional; Region: PRK12804 1045858005595 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045858005596 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1045858005597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1045858005598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858005599 DNA binding residues [nucleotide binding] 1045858005600 asparaginyl-tRNA synthetase; Region: PLN02603 1045858005601 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1045858005602 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1045858005603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1045858005604 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1045858005605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1045858005606 DNA binding residues [nucleotide binding] 1045858005607 DNA primase, catalytic core; Region: dnaG; TIGR01391 1045858005608 CHC2 zinc finger; Region: zf-CHC2; cl17510 1045858005609 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1045858005610 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1045858005611 active site 1045858005612 metal binding site [ion binding]; metal-binding site 1045858005613 interdomain interaction site; other site 1045858005614 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 1045858005615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1045858005616 nudix motif; other site 1045858005617 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1045858005618 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1045858005619 Catalytic site [active] 1045858005620 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1045858005621 AzlC protein; Region: AzlC; cl00570 1045858005622 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1045858005623 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858005624 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858005625 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858005626 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858005627 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1045858005628 dimer interface [polypeptide binding]; other site 1045858005629 catalytic residues [active] 1045858005630 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1045858005631 dimer interface [polypeptide binding]; other site 1045858005632 catalytic triad [active] 1045858005633 peroxidatic and resolving cysteines [active] 1045858005634 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045858005635 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045858005636 active site 1045858005637 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1045858005638 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1045858005639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858005640 active site 1045858005641 phosphorylation site [posttranslational modification] 1045858005642 intermolecular recognition site; other site 1045858005643 dimerization interface [polypeptide binding]; other site 1045858005644 DNA gyrase subunit A; Validated; Region: PRK05560 1045858005645 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1045858005646 CAP-like domain; other site 1045858005647 active site 1045858005648 primary dimer interface [polypeptide binding]; other site 1045858005649 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045858005650 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045858005651 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045858005652 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045858005653 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1045858005654 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045858005655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045858005656 Walker A/P-loop; other site 1045858005657 ATP binding site [chemical binding]; other site 1045858005658 Q-loop/lid; other site 1045858005659 ABC transporter signature motif; other site 1045858005660 Walker B; other site 1045858005661 D-loop; other site 1045858005662 H-loop/switch region; other site 1045858005663 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1045858005664 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1045858005665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858005666 ATP binding site [chemical binding]; other site 1045858005667 putative Mg++ binding site [ion binding]; other site 1045858005668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045858005669 nucleotide binding region [chemical binding]; other site 1045858005670 ATP-binding site [chemical binding]; other site 1045858005671 TRCF domain; Region: TRCF; pfam03461 1045858005672 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1045858005673 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1045858005674 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1045858005675 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1045858005676 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1045858005677 putative substrate binding site [chemical binding]; other site 1045858005678 putative ATP binding site [chemical binding]; other site 1045858005679 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1045858005680 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858005681 active site 1045858005682 phosphorylation site [posttranslational modification] 1045858005683 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1045858005684 active site 1045858005685 P-loop; other site 1045858005686 phosphorylation site [posttranslational modification] 1045858005687 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1045858005688 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858005689 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858005690 peptide binding site [polypeptide binding]; other site 1045858005691 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858005692 peptide binding site [polypeptide binding]; other site 1045858005693 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1045858005694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005696 dimer interface [polypeptide binding]; other site 1045858005697 putative CheW interface [polypeptide binding]; other site 1045858005698 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858005699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005700 dimer interface [polypeptide binding]; other site 1045858005701 putative CheW interface [polypeptide binding]; other site 1045858005702 Cache domain; Region: Cache_1; pfam02743 1045858005703 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858005704 dimer interface [polypeptide binding]; other site 1045858005705 putative CheW interface [polypeptide binding]; other site 1045858005706 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858005707 putative efflux protein, MATE family; Region: matE; TIGR00797 1045858005708 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1045858005709 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1045858005710 active site 1045858005711 metal binding site [ion binding]; metal-binding site 1045858005712 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045858005713 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045858005714 active site residue [active] 1045858005715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858005716 Walker A/P-loop; other site 1045858005717 ATP binding site [chemical binding]; other site 1045858005718 AAA ATPase domain; Region: AAA_15; pfam13175 1045858005719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858005720 Walker B; other site 1045858005721 D-loop; other site 1045858005722 H-loop/switch region; other site 1045858005723 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1045858005724 DNA-binding interface [nucleotide binding]; DNA binding site 1045858005725 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1045858005726 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1045858005727 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1045858005728 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1045858005729 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1045858005730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1045858005731 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 1045858005732 tetramerization interface [polypeptide binding]; other site 1045858005733 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 1045858005734 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1045858005735 SirA-like protein; Region: SirA; pfam01206 1045858005736 CPxP motif; other site 1045858005737 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1045858005738 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1045858005739 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1045858005740 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1045858005741 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1045858005742 dimer interface [polypeptide binding]; other site 1045858005743 ssDNA binding site [nucleotide binding]; other site 1045858005744 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045858005745 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1045858005746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858005747 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1045858005748 putative substrate translocation pore; other site 1045858005749 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1045858005750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1045858005751 catalytic residues [active] 1045858005752 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005753 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005754 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1045858005755 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1045858005756 active site 2 [active] 1045858005757 active site 1 [active] 1045858005758 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1045858005759 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1045858005760 tartrate dehydrogenase; Region: TTC; TIGR02089 1045858005761 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1045858005762 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1045858005763 substrate binding site [chemical binding]; other site 1045858005764 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1045858005765 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1045858005766 substrate binding site [chemical binding]; other site 1045858005767 ligand binding site [chemical binding]; other site 1045858005768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005769 binding surface 1045858005770 TPR motif; other site 1045858005771 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1045858005772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858005773 binding surface 1045858005774 TPR motif; other site 1045858005775 TPR repeat; Region: TPR_11; pfam13414 1045858005776 2-isopropylmalate synthase; Validated; Region: PRK00915 1045858005777 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1045858005778 active site 1045858005779 catalytic residues [active] 1045858005780 metal binding site [ion binding]; metal-binding site 1045858005781 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1045858005782 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1045858005783 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1045858005784 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1045858005785 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1045858005786 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1045858005787 putative valine binding site [chemical binding]; other site 1045858005788 dimer interface [polypeptide binding]; other site 1045858005789 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1045858005790 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1045858005791 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1045858005792 PYR/PP interface [polypeptide binding]; other site 1045858005793 dimer interface [polypeptide binding]; other site 1045858005794 TPP binding site [chemical binding]; other site 1045858005795 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1045858005796 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1045858005797 TPP-binding site [chemical binding]; other site 1045858005798 dimer interface [polypeptide binding]; other site 1045858005799 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1045858005800 putative active site [active] 1045858005801 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1045858005802 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1045858005803 active site 1045858005804 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1045858005805 active site 1045858005806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858005807 META domain; Region: META; pfam03724 1045858005808 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005809 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005810 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005811 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005812 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005813 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005814 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005815 GTPase RsgA; Reviewed; Region: PRK01889 1045858005816 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045858005817 RNA binding site [nucleotide binding]; other site 1045858005818 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1045858005819 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1045858005820 GTP/Mg2+ binding site [chemical binding]; other site 1045858005821 G4 box; other site 1045858005822 G5 box; other site 1045858005823 G1 box; other site 1045858005824 Switch I region; other site 1045858005825 G2 box; other site 1045858005826 G3 box; other site 1045858005827 Switch II region; other site 1045858005828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858005829 putative substrate translocation pore; other site 1045858005830 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1045858005831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1045858005832 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1045858005833 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045858005834 dimerization interface [polypeptide binding]; other site 1045858005835 putative DNA binding site [nucleotide binding]; other site 1045858005836 putative Zn2+ binding site [ion binding]; other site 1045858005837 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1045858005838 putative CoA binding site [chemical binding]; other site 1045858005839 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1045858005840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858005841 S-adenosylmethionine binding site [chemical binding]; other site 1045858005842 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1045858005843 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1045858005844 putative catalytic cysteine [active] 1045858005845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1045858005846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045858005847 P-loop; other site 1045858005848 Magnesium ion binding site [ion binding]; other site 1045858005849 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1045858005850 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1045858005851 Magnesium ion binding site [ion binding]; other site 1045858005852 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1045858005853 ParB-like nuclease domain; Region: ParB; smart00470 1045858005854 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1045858005855 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1045858005856 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1045858005857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045858005858 putative active site [active] 1045858005859 metal binding site [ion binding]; metal-binding site 1045858005860 homodimer binding site [polypeptide binding]; other site 1045858005861 phosphodiesterase; Provisional; Region: PRK12704 1045858005862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858005863 Zn2+ binding site [ion binding]; other site 1045858005864 Mg2+ binding site [ion binding]; other site 1045858005865 Rubrerythrin [Energy production and conversion]; Region: COG1592 1045858005866 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1045858005867 binuclear metal center [ion binding]; other site 1045858005868 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1045858005869 iron binding site [ion binding]; other site 1045858005870 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1045858005871 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 1045858005872 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1045858005873 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1045858005874 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1045858005875 Cl- selectivity filter; other site 1045858005876 Cl- binding residues [ion binding]; other site 1045858005877 pore gating glutamate residue; other site 1045858005878 dimer interface [polypeptide binding]; other site 1045858005879 H+/Cl- coupling transport residue; other site 1045858005880 GTP-binding protein YchF; Reviewed; Region: PRK09601 1045858005881 YchF GTPase; Region: YchF; cd01900 1045858005882 G1 box; other site 1045858005883 GTP/Mg2+ binding site [chemical binding]; other site 1045858005884 Switch I region; other site 1045858005885 G2 box; other site 1045858005886 Switch II region; other site 1045858005887 G3 box; other site 1045858005888 G4 box; other site 1045858005889 G5 box; other site 1045858005890 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1045858005891 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1045858005892 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1045858005893 iron-sulfur cluster [ion binding]; other site 1045858005894 [2Fe-2S] cluster binding site [ion binding]; other site 1045858005895 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1045858005896 hydrophobic ligand binding site; other site 1045858005897 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1045858005898 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1045858005899 active site 1045858005900 Riboflavin kinase; Region: Flavokinase; smart00904 1045858005901 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1045858005902 16S/18S rRNA binding site [nucleotide binding]; other site 1045858005903 S13e-L30e interaction site [polypeptide binding]; other site 1045858005904 25S rRNA binding site [nucleotide binding]; other site 1045858005905 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1045858005906 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1045858005907 RNase E interface [polypeptide binding]; other site 1045858005908 trimer interface [polypeptide binding]; other site 1045858005909 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1045858005910 RNase E interface [polypeptide binding]; other site 1045858005911 trimer interface [polypeptide binding]; other site 1045858005912 active site 1045858005913 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1045858005914 putative nucleic acid binding region [nucleotide binding]; other site 1045858005915 G-X-X-G motif; other site 1045858005916 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1045858005917 RNA binding site [nucleotide binding]; other site 1045858005918 domain interface; other site 1045858005919 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005920 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005921 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005922 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005923 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005924 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1045858005925 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1045858005926 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1045858005927 active site 1045858005928 substrate-binding site [chemical binding]; other site 1045858005929 metal-binding site [ion binding] 1045858005930 GTP binding site [chemical binding]; other site 1045858005931 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858005932 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858005933 peptide binding site [polypeptide binding]; other site 1045858005934 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1045858005935 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 1045858005936 Peptidase C26; Region: Peptidase_C26; pfam07722 1045858005937 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1045858005938 catalytic triad [active] 1045858005939 recombinase A; Provisional; Region: recA; PRK09354 1045858005940 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1045858005941 hexamer interface [polypeptide binding]; other site 1045858005942 Walker A motif; other site 1045858005943 ATP binding site [chemical binding]; other site 1045858005944 Walker B motif; other site 1045858005945 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1045858005946 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1045858005947 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1045858005948 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1045858005949 methionine sulfoxide reductase B; Provisional; Region: PRK05508 1045858005950 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1045858005951 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1045858005952 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1045858005953 putative active site [active] 1045858005954 putative metal binding site [ion binding]; other site 1045858005955 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1045858005956 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1045858005957 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1045858005958 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1045858005959 dimer interface [polypeptide binding]; other site 1045858005960 putative anticodon binding site; other site 1045858005961 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1045858005962 motif 1; other site 1045858005963 active site 1045858005964 motif 2; other site 1045858005965 motif 3; other site 1045858005966 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858005967 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858005968 peptide binding site [polypeptide binding]; other site 1045858005969 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858005970 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005971 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005972 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005973 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005974 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005975 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005976 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005977 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005978 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005979 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005980 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005981 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005982 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005983 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005984 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005985 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005986 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005987 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005988 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005989 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005990 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005991 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005992 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005993 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858005994 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858005995 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858005996 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858005997 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1045858005998 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858005999 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1045858006000 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1045858006001 MutS domain I; Region: MutS_I; pfam01624 1045858006002 MutS domain II; Region: MutS_II; pfam05188 1045858006003 MutS domain III; Region: MutS_III; pfam05192 1045858006004 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1045858006005 Walker A/P-loop; other site 1045858006006 ATP binding site [chemical binding]; other site 1045858006007 Q-loop/lid; other site 1045858006008 ABC transporter signature motif; other site 1045858006009 Walker B; other site 1045858006010 D-loop; other site 1045858006011 H-loop/switch region; other site 1045858006012 Cupin domain; Region: Cupin_2; pfam07883 1045858006013 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1045858006014 trimer interface [polypeptide binding]; other site 1045858006015 active site 1045858006016 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1045858006017 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1045858006018 active site 1045858006019 dimer interface [polypeptide binding]; other site 1045858006020 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1045858006021 dimer interface [polypeptide binding]; other site 1045858006022 active site 1045858006023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858006024 S-adenosylmethionine binding site [chemical binding]; other site 1045858006025 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1045858006026 metal ion-dependent adhesion site (MIDAS); other site 1045858006027 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1045858006028 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1045858006029 active site 1045858006030 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1045858006031 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1045858006032 NAD binding site [chemical binding]; other site 1045858006033 sugar binding site [chemical binding]; other site 1045858006034 divalent metal binding site [ion binding]; other site 1045858006035 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1045858006036 dimer interface [polypeptide binding]; other site 1045858006037 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1045858006038 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045858006039 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858006040 active site turn [active] 1045858006041 phosphorylation site [posttranslational modification] 1045858006042 alpha-galactosidase; Provisional; Region: PRK15076 1045858006043 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1045858006044 NAD(P) binding site [chemical binding]; other site 1045858006045 LDH/MDH dimer interface [polypeptide binding]; other site 1045858006046 substrate binding site [chemical binding]; other site 1045858006047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1045858006048 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1045858006049 ligand binding site [chemical binding]; other site 1045858006050 dimerization interface [polypeptide binding]; other site 1045858006051 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045858006052 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 1045858006053 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1045858006054 active site 1045858006055 catalytic site [active] 1045858006056 homodimer interface [polypeptide binding]; other site 1045858006057 Lid 1; other site 1045858006058 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 1045858006059 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 1045858006060 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1045858006061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858006062 Zn2+ binding site [ion binding]; other site 1045858006063 Mg2+ binding site [ion binding]; other site 1045858006064 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1045858006065 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006066 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858006067 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 1045858006068 amidophosphoribosyltransferase; Provisional; Region: PRK05793 1045858006069 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1045858006070 active site 1045858006071 tetramer interface [polypeptide binding]; other site 1045858006072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858006073 active site 1045858006074 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1045858006075 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1045858006076 ATP binding site [chemical binding]; other site 1045858006077 active site 1045858006078 substrate binding site [chemical binding]; other site 1045858006079 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1045858006080 Predicted ATPases [General function prediction only]; Region: COG1106 1045858006081 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 1045858006082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858006083 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1045858006084 Walker A motif; other site 1045858006085 ATP binding site [chemical binding]; other site 1045858006086 Walker B motif; other site 1045858006087 arginine finger; other site 1045858006088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1045858006089 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858006090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858006091 dimer interface [polypeptide binding]; other site 1045858006092 putative CheW interface [polypeptide binding]; other site 1045858006093 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1045858006094 dimer interface [polypeptide binding]; other site 1045858006095 motif 1; other site 1045858006096 active site 1045858006097 motif 2; other site 1045858006098 motif 3; other site 1045858006099 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1045858006100 dinuclear metal binding motif [ion binding]; other site 1045858006101 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1045858006102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858006103 active site 1045858006104 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858006105 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858006106 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1045858006107 Part of AAA domain; Region: AAA_19; pfam13245 1045858006108 Family description; Region: UvrD_C_2; pfam13538 1045858006109 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1045858006110 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1045858006111 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1045858006112 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1045858006113 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1045858006114 YbbR-like protein; Region: YbbR; pfam07949 1045858006115 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 1045858006116 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 1045858006117 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1045858006118 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1045858006119 TPR repeat; Region: TPR_11; pfam13414 1045858006120 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858006121 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006122 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006123 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006124 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006125 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006126 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006127 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1045858006128 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1045858006129 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1045858006130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006131 Walker A/P-loop; other site 1045858006132 ATP binding site [chemical binding]; other site 1045858006133 Q-loop/lid; other site 1045858006134 ABC transporter signature motif; other site 1045858006135 Walker B; other site 1045858006136 D-loop; other site 1045858006137 H-loop/switch region; other site 1045858006138 HEAT repeats; Region: HEAT_2; pfam13646 1045858006139 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1045858006140 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1045858006141 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1045858006142 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1045858006143 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1045858006144 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1045858006145 dimerization domain swap beta strand [polypeptide binding]; other site 1045858006146 regulatory protein interface [polypeptide binding]; other site 1045858006147 active site 1045858006148 regulatory phosphorylation site [posttranslational modification]; other site 1045858006149 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1045858006150 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1045858006151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006153 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858006154 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858006155 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1045858006156 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1045858006157 metal binding site [ion binding]; metal-binding site 1045858006158 dimer interface [polypeptide binding]; other site 1045858006159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858006160 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1045858006161 active site 1045858006162 motif I; other site 1045858006163 motif II; other site 1045858006164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858006165 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1045858006166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858006167 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1045858006168 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1045858006169 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1045858006170 dimerization interface [polypeptide binding]; other site 1045858006171 ATP binding site [chemical binding]; other site 1045858006172 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1045858006173 dimerization interface [polypeptide binding]; other site 1045858006174 ATP binding site [chemical binding]; other site 1045858006175 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1045858006176 putative active site [active] 1045858006177 catalytic triad [active] 1045858006178 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1045858006179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1045858006180 putative metal binding site [ion binding]; other site 1045858006181 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1045858006182 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1045858006183 active site 1045858006184 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1045858006185 elongation factor G; Reviewed; Region: PRK12740 1045858006186 G1 box; other site 1045858006187 putative GEF interaction site [polypeptide binding]; other site 1045858006188 GTP/Mg2+ binding site [chemical binding]; other site 1045858006189 Switch I region; other site 1045858006190 G2 box; other site 1045858006191 G3 box; other site 1045858006192 Switch II region; other site 1045858006193 G4 box; other site 1045858006194 G5 box; other site 1045858006195 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1045858006196 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1045858006197 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1045858006198 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858006199 active site 1045858006200 phosphorylation site [posttranslational modification] 1045858006201 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1045858006202 Putative zinc ribbon domain; Region: DUF164; pfam02591 1045858006203 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1045858006204 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1045858006205 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1045858006206 ADP binding site [chemical binding]; other site 1045858006207 magnesium binding site [ion binding]; other site 1045858006208 putative shikimate binding site; other site 1045858006209 Chorismate mutase type II; Region: CM_2; smart00830 1045858006210 prephenate dehydratase; Provisional; Region: PRK11898 1045858006211 Prephenate dehydratase; Region: PDT; pfam00800 1045858006212 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1045858006213 putative L-Phe binding site [chemical binding]; other site 1045858006214 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1045858006215 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1045858006216 DNA binding residues [nucleotide binding] 1045858006217 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1045858006218 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1045858006219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045858006220 active site 1045858006221 nucleotide binding site [chemical binding]; other site 1045858006222 HIGH motif; other site 1045858006223 KMSKS motif; other site 1045858006224 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1045858006225 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1045858006226 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1045858006227 metal ion-dependent adhesion site (MIDAS); other site 1045858006228 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1045858006229 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1045858006230 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1045858006231 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1045858006232 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1045858006233 PLD-like domain; Region: PLDc_2; pfam13091 1045858006234 homodimer interface [polypeptide binding]; other site 1045858006235 putative active site [active] 1045858006236 catalytic site [active] 1045858006237 recombination protein F; Reviewed; Region: recF; PRK00064 1045858006238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006239 Walker A/P-loop; other site 1045858006240 ATP binding site [chemical binding]; other site 1045858006241 Q-loop/lid; other site 1045858006242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006243 ABC transporter signature motif; other site 1045858006244 Walker B; other site 1045858006245 D-loop; other site 1045858006246 H-loop/switch region; other site 1045858006247 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006248 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006249 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006250 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006251 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006252 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1045858006253 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858006254 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1045858006255 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858006256 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858006257 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006258 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006259 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006260 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006261 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006262 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1045858006263 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1045858006264 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1045858006265 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1045858006266 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1045858006267 MarR family; Region: MarR_2; pfam12802 1045858006268 Flagellin N-methylase; Region: FliB; cl00497 1045858006269 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1045858006270 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1045858006271 B12 binding site [chemical binding]; other site 1045858006272 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1045858006273 SurA N-terminal domain; Region: SurA_N; pfam09312 1045858006274 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1045858006275 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1045858006276 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1045858006277 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1045858006278 catalytic site [active] 1045858006279 subunit interface [polypeptide binding]; other site 1045858006280 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1045858006281 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045858006282 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1045858006283 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1045858006284 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1045858006285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1045858006286 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1045858006287 IMP binding site; other site 1045858006288 dimer interface [polypeptide binding]; other site 1045858006289 interdomain contacts; other site 1045858006290 partial ornithine binding site; other site 1045858006291 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1045858006292 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1045858006293 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1045858006294 putative homodimer interface [polypeptide binding]; other site 1045858006295 putative active site pocket [active] 1045858006296 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1045858006297 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1045858006298 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1045858006299 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 1045858006300 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1045858006301 DctM-like transporters; Region: DctM; pfam06808 1045858006302 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1045858006303 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858006304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858006305 homodimer interface [polypeptide binding]; other site 1045858006306 catalytic residue [active] 1045858006307 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1045858006308 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1045858006309 active site 1045858006310 dimerization interface [polypeptide binding]; other site 1045858006311 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1045858006312 Carbon starvation protein CstA; Region: CstA; pfam02554 1045858006313 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1045858006314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858006315 TPR motif; other site 1045858006316 TPR repeat; Region: TPR_11; pfam13414 1045858006317 binding surface 1045858006318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858006319 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1045858006320 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1045858006321 Potassium binding sites [ion binding]; other site 1045858006322 Cesium cation binding sites [ion binding]; other site 1045858006323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045858006324 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045858006325 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1045858006326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1045858006327 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 1045858006328 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 1045858006329 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1045858006330 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1045858006331 dimer interface [polypeptide binding]; other site 1045858006332 active site 1045858006333 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1045858006334 folate binding site [chemical binding]; other site 1045858006335 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1045858006336 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1045858006337 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1045858006338 active site 1045858006339 trimer interface [polypeptide binding]; other site 1045858006340 allosteric site; other site 1045858006341 active site lid [active] 1045858006342 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1045858006343 phosphopentomutase; Provisional; Region: PRK05362 1045858006344 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1045858006345 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1045858006346 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1045858006347 active site 1045858006348 metal binding site [ion binding]; metal-binding site 1045858006349 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1045858006350 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1045858006351 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1045858006352 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1045858006353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858006354 dimer interface [polypeptide binding]; other site 1045858006355 conserved gate region; other site 1045858006356 putative PBP binding loops; other site 1045858006357 ABC-ATPase subunit interface; other site 1045858006358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1045858006359 dimer interface [polypeptide binding]; other site 1045858006360 conserved gate region; other site 1045858006361 putative PBP binding loops; other site 1045858006362 ABC-ATPase subunit interface; other site 1045858006363 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1045858006364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006365 Walker A/P-loop; other site 1045858006366 ATP binding site [chemical binding]; other site 1045858006367 Q-loop/lid; other site 1045858006368 ABC transporter signature motif; other site 1045858006369 Walker B; other site 1045858006370 D-loop; other site 1045858006371 H-loop/switch region; other site 1045858006372 TOBE domain; Region: TOBE_2; pfam08402 1045858006373 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1045858006374 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1045858006375 FtsX-like permease family; Region: FtsX; pfam02687 1045858006376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1045858006377 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1045858006378 Walker A/P-loop; other site 1045858006379 ATP binding site [chemical binding]; other site 1045858006380 Q-loop/lid; other site 1045858006381 ABC transporter signature motif; other site 1045858006382 Walker B; other site 1045858006383 D-loop; other site 1045858006384 H-loop/switch region; other site 1045858006385 Predicted transcriptional regulators [Transcription]; Region: COG1695 1045858006386 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1045858006387 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1045858006388 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1045858006389 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1045858006390 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1045858006391 Walker A/P-loop; other site 1045858006392 ATP binding site [chemical binding]; other site 1045858006393 Q-loop/lid; other site 1045858006394 ABC transporter signature motif; other site 1045858006395 Walker B; other site 1045858006396 D-loop; other site 1045858006397 H-loop/switch region; other site 1045858006398 CAAX protease self-immunity; Region: Abi; pfam02517 1045858006399 YcaO-like family; Region: YcaO; pfam02624 1045858006400 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1045858006401 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 1045858006402 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1045858006403 NADPH bind site [chemical binding]; other site 1045858006404 putative FMN binding site [chemical binding]; other site 1045858006405 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1045858006406 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1045858006407 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1045858006408 NAD binding site [chemical binding]; other site 1045858006409 Phe binding site; other site 1045858006410 Protein of unknown function (DUF454); Region: DUF454; cl01063 1045858006411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045858006412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045858006413 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1045858006414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045858006415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006416 Walker A/P-loop; other site 1045858006417 ATP binding site [chemical binding]; other site 1045858006418 Q-loop/lid; other site 1045858006419 ABC transporter signature motif; other site 1045858006420 Walker B; other site 1045858006421 D-loop; other site 1045858006422 H-loop/switch region; other site 1045858006423 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1045858006424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1045858006425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006426 Walker A/P-loop; other site 1045858006427 ATP binding site [chemical binding]; other site 1045858006428 Q-loop/lid; other site 1045858006429 ABC transporter signature motif; other site 1045858006430 Walker B; other site 1045858006431 D-loop; other site 1045858006432 H-loop/switch region; other site 1045858006433 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006434 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006435 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1045858006436 catalytic residues [active] 1045858006437 dimer interface [polypeptide binding]; other site 1045858006438 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1045858006439 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1045858006440 homodimer interface [polypeptide binding]; other site 1045858006441 metal binding site [ion binding]; metal-binding site 1045858006442 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1045858006443 homodimer interface [polypeptide binding]; other site 1045858006444 active site 1045858006445 putative chemical substrate binding site [chemical binding]; other site 1045858006446 metal binding site [ion binding]; metal-binding site 1045858006447 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 1045858006448 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 1045858006449 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1045858006450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045858006451 RNA binding surface [nucleotide binding]; other site 1045858006452 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1045858006453 active site 1045858006454 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1045858006455 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1045858006456 RNB domain; Region: RNB; pfam00773 1045858006457 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1045858006458 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1045858006459 RNA binding site [nucleotide binding]; other site 1045858006460 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1045858006461 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045858006462 motif 1; other site 1045858006463 dimer interface [polypeptide binding]; other site 1045858006464 active site 1045858006465 motif 2; other site 1045858006466 motif 3; other site 1045858006467 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1045858006468 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1045858006469 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1045858006470 histidinol dehydrogenase; Region: hisD; TIGR00069 1045858006471 NAD binding site [chemical binding]; other site 1045858006472 dimerization interface [polypeptide binding]; other site 1045858006473 product binding site; other site 1045858006474 substrate binding site [chemical binding]; other site 1045858006475 zinc binding site [ion binding]; other site 1045858006476 catalytic residues [active] 1045858006477 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1045858006478 gating phenylalanine in ion channel; other site 1045858006479 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1045858006480 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1045858006481 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1045858006482 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1045858006483 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1045858006484 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1045858006485 cleft; other site 1045858006486 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1045858006487 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1045858006488 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1045858006489 DNA binding site [nucleotide binding] 1045858006490 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1045858006491 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1045858006492 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1045858006493 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1045858006494 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1045858006495 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1045858006496 RPB10 interaction site [polypeptide binding]; other site 1045858006497 RPB1 interaction site [polypeptide binding]; other site 1045858006498 RPB11 interaction site [polypeptide binding]; other site 1045858006499 RPB3 interaction site [polypeptide binding]; other site 1045858006500 RPB12 interaction site [polypeptide binding]; other site 1045858006501 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1045858006502 core dimer interface [polypeptide binding]; other site 1045858006503 peripheral dimer interface [polypeptide binding]; other site 1045858006504 L10 interface [polypeptide binding]; other site 1045858006505 L11 interface [polypeptide binding]; other site 1045858006506 putative EF-Tu interaction site [polypeptide binding]; other site 1045858006507 putative EF-G interaction site [polypeptide binding]; other site 1045858006508 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1045858006509 23S rRNA interface [nucleotide binding]; other site 1045858006510 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1045858006511 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1045858006512 mRNA/rRNA interface [nucleotide binding]; other site 1045858006513 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1045858006514 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1045858006515 23S rRNA interface [nucleotide binding]; other site 1045858006516 L7/L12 interface [polypeptide binding]; other site 1045858006517 putative thiostrepton binding site; other site 1045858006518 L25 interface [polypeptide binding]; other site 1045858006519 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1045858006520 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1045858006521 putative homodimer interface [polypeptide binding]; other site 1045858006522 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1045858006523 heterodimer interface [polypeptide binding]; other site 1045858006524 homodimer interface [polypeptide binding]; other site 1045858006525 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1045858006526 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1045858006527 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1045858006528 LrgB-like family; Region: LrgB; pfam04172 1045858006529 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045858006530 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1045858006531 substrate binding site [chemical binding]; other site 1045858006532 dimer interface [polypeptide binding]; other site 1045858006533 ATP binding site [chemical binding]; other site 1045858006534 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858006535 Protein export membrane protein; Region: SecD_SecF; cl14618 1045858006536 Serpentine type 7TM GPCR receptor class ab chemoreceptor; Region: 7TM_GPCR_Srab; cl11607 1045858006537 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1045858006538 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1045858006539 active site 1045858006540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858006541 S-adenosylmethionine binding site [chemical binding]; other site 1045858006542 Acylphosphatase; Region: Acylphosphatase; pfam00708 1045858006543 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858006544 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858006545 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858006546 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858006547 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1045858006548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858006549 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1045858006550 Peptidase family M23; Region: Peptidase_M23; pfam01551 1045858006551 Cache domain; Region: Cache_1; pfam02743 1045858006552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858006553 dimer interface [polypeptide binding]; other site 1045858006554 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1045858006555 putative CheW interface [polypeptide binding]; other site 1045858006556 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858006557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858006558 dimer interface [polypeptide binding]; other site 1045858006559 putative CheW interface [polypeptide binding]; other site 1045858006560 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1045858006561 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1045858006562 active site 1045858006563 substrate binding site [chemical binding]; other site 1045858006564 catalytic site [active] 1045858006565 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1045858006566 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1045858006567 metal binding site 2 [ion binding]; metal-binding site 1045858006568 putative DNA binding helix; other site 1045858006569 metal binding site 1 [ion binding]; metal-binding site 1045858006570 dimer interface [polypeptide binding]; other site 1045858006571 structural Zn2+ binding site [ion binding]; other site 1045858006572 Late competence development protein ComFB; Region: ComFB; pfam10719 1045858006573 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1045858006574 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1045858006575 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858006576 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1045858006577 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1045858006578 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1045858006579 active site 1045858006580 substrate binding site [chemical binding]; other site 1045858006581 metal binding site [ion binding]; metal-binding site 1045858006582 Abi-like protein; Region: Abi_2; pfam07751 1045858006583 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1045858006584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858006585 ATP binding site [chemical binding]; other site 1045858006586 putative Mg++ binding site [ion binding]; other site 1045858006587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045858006588 nucleotide binding region [chemical binding]; other site 1045858006589 ATP-binding site [chemical binding]; other site 1045858006590 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1045858006591 PilZ domain; Region: PilZ; pfam07238 1045858006592 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1045858006593 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1045858006594 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1045858006595 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1045858006596 AAA domain; Region: AAA_23; pfam13476 1045858006597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006598 Walker A/P-loop; other site 1045858006599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858006600 Walker B; other site 1045858006601 D-loop; other site 1045858006602 H-loop/switch region; other site 1045858006603 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1045858006604 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1045858006605 TrkA-N domain; Region: TrkA_N; pfam02254 1045858006606 TrkA-C domain; Region: TrkA_C; pfam02080 1045858006607 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006608 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045858006610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1045858006611 Coenzyme A binding pocket [chemical binding]; other site 1045858006612 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1045858006613 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1045858006614 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1045858006615 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 1045858006616 L-serine binding site [chemical binding]; other site 1045858006617 TPR repeat; Region: TPR_11; pfam13414 1045858006618 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1045858006619 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1045858006620 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1045858006621 active site 1045858006622 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1045858006623 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1045858006624 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1045858006625 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1045858006626 catalytic residues [active] 1045858006627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858006628 TPR repeat; Region: TPR_11; pfam13414 1045858006629 TPR motif; other site 1045858006630 binding surface 1045858006631 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1045858006632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858006633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858006634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858006635 binding surface 1045858006636 TPR motif; other site 1045858006637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1045858006638 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1045858006639 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1045858006640 HIGH motif; other site 1045858006641 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1045858006642 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045858006643 active site 1045858006644 KMSKS motif; other site 1045858006645 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1045858006646 tRNA binding surface [nucleotide binding]; other site 1045858006647 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1045858006648 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1045858006649 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1045858006650 putative NAD(P) binding site [chemical binding]; other site 1045858006651 putative substrate binding site [chemical binding]; other site 1045858006652 catalytic Zn binding site [ion binding]; other site 1045858006653 structural Zn binding site [ion binding]; other site 1045858006654 dimer interface [polypeptide binding]; other site 1045858006655 Rubrerythrin [Energy production and conversion]; Region: COG1592 1045858006656 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1045858006657 dinuclear metal binding motif [ion binding]; other site 1045858006658 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1045858006659 iron binding site [ion binding]; other site 1045858006660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858006661 S-adenosylmethionine binding site [chemical binding]; other site 1045858006662 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1045858006663 active site 1045858006664 catalytic residues [active] 1045858006665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1045858006666 dimerization interface [polypeptide binding]; other site 1045858006667 putative DNA binding site [nucleotide binding]; other site 1045858006668 putative Zn2+ binding site [ion binding]; other site 1045858006669 Predicted permeases [General function prediction only]; Region: COG0701 1045858006670 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1045858006671 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1045858006672 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1045858006673 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1045858006674 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045858006675 substrate binding site [chemical binding]; other site 1045858006676 ATP binding site [chemical binding]; other site 1045858006677 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1045858006678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1045858006679 DNA-binding site [nucleotide binding]; DNA binding site 1045858006680 FCD domain; Region: FCD; pfam07729 1045858006681 beta-D-glucuronidase; Provisional; Region: PRK10150 1045858006682 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1045858006683 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1045858006684 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1045858006685 MFS/sugar transport protein; Region: MFS_2; pfam13347 1045858006686 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1045858006687 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1045858006688 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1045858006689 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1045858006690 mannonate dehydratase; Provisional; Region: PRK03906 1045858006691 mannonate dehydratase; Region: uxuA; TIGR00695 1045858006692 Glucuronate isomerase; Region: UxaC; pfam02614 1045858006693 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1045858006694 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1045858006695 active site 1045858006696 intersubunit interface [polypeptide binding]; other site 1045858006697 catalytic residue [active] 1045858006698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858006699 TPR motif; other site 1045858006700 TPR repeat; Region: TPR_11; pfam13414 1045858006701 binding surface 1045858006702 DJ-1 family protein; Region: not_thiJ; TIGR01383 1045858006703 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1045858006704 conserved cys residue [active] 1045858006705 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1045858006706 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1045858006707 active site 1045858006708 Substrate binding site; other site 1045858006709 Mg++ binding site; other site 1045858006710 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1045858006711 putative trimer interface [polypeptide binding]; other site 1045858006712 putative CoA binding site [chemical binding]; other site 1045858006713 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 1045858006714 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1045858006715 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1045858006716 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1045858006717 RF-1 domain; Region: RF-1; pfam00472 1045858006718 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1045858006719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1045858006720 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1045858006721 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1045858006722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1045858006723 active site 1045858006724 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1045858006725 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1045858006726 Rubredoxin [Energy production and conversion]; Region: COG1773 1045858006727 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1045858006728 iron binding site [ion binding]; other site 1045858006729 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 1045858006730 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1045858006731 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1045858006732 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858006733 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858006734 peptide binding site [polypeptide binding]; other site 1045858006735 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858006736 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858006737 peptide binding site [polypeptide binding]; other site 1045858006738 elongation factor P; Validated; Region: PRK00529 1045858006739 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1045858006740 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1045858006741 RNA binding site [nucleotide binding]; other site 1045858006742 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1045858006743 RNA binding site [nucleotide binding]; other site 1045858006744 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1045858006745 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1045858006746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858006747 Walker A motif; other site 1045858006748 ATP binding site [chemical binding]; other site 1045858006749 Walker B motif; other site 1045858006750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045858006751 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1045858006752 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1045858006753 oligomer interface [polypeptide binding]; other site 1045858006754 active site residues [active] 1045858006755 trigger factor; Region: tig; TIGR00115 1045858006756 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1045858006757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858006758 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1045858006759 active site 1045858006760 motif I; other site 1045858006761 motif II; other site 1045858006762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858006763 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1045858006764 RNA/DNA hybrid binding site [nucleotide binding]; other site 1045858006765 active site 1045858006766 V-type ATP synthase subunit I; Validated; Region: PRK05771 1045858006767 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1045858006768 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1045858006769 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1045858006770 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1045858006771 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1045858006772 Rubrerythrin [Energy production and conversion]; Region: COG1592 1045858006773 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1045858006774 binuclear metal center [ion binding]; other site 1045858006775 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1045858006776 iron binding site [ion binding]; other site 1045858006777 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1045858006778 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1045858006779 active site 1045858006780 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1045858006781 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1045858006782 Protein of unknown function, DUF486; Region: DUF486; cl01236 1045858006783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1045858006784 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045858006785 Cache domain; Region: Cache_1; pfam02743 1045858006786 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858006787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858006788 dimer interface [polypeptide binding]; other site 1045858006789 putative CheW interface [polypeptide binding]; other site 1045858006790 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1045858006791 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045858006792 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858006793 active site turn [active] 1045858006794 phosphorylation site [posttranslational modification] 1045858006795 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1045858006796 HPr interaction site; other site 1045858006797 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045858006798 active site 1045858006799 phosphorylation site [posttranslational modification] 1045858006800 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1045858006801 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1045858006802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858006803 FeS/SAM binding site; other site 1045858006804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1045858006805 active site 1045858006806 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006807 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006808 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858006809 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006810 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006811 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006812 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006813 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858006814 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006815 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006816 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1045858006817 core domain interface [polypeptide binding]; other site 1045858006818 delta subunit interface [polypeptide binding]; other site 1045858006819 epsilon subunit interface [polypeptide binding]; other site 1045858006820 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1045858006821 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045858006822 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1045858006823 beta subunit interaction interface [polypeptide binding]; other site 1045858006824 Walker A motif; other site 1045858006825 ATP binding site [chemical binding]; other site 1045858006826 Walker B motif; other site 1045858006827 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1045858006828 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1045858006829 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1045858006830 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1045858006831 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1045858006832 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1045858006833 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1045858006834 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 1045858006835 ATP synthase A chain; Region: ATP-synt_A; cl00413 1045858006836 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1045858006837 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1045858006838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1045858006839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1045858006840 Outer membrane efflux protein; Region: OEP; pfam02321 1045858006841 Outer membrane efflux protein; Region: OEP; pfam02321 1045858006842 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858006843 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1045858006844 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1045858006845 active site 1045858006846 nucleotide binding site [chemical binding]; other site 1045858006847 HIGH motif; other site 1045858006848 KMSKS motif; other site 1045858006849 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1045858006850 23S rRNA interface [nucleotide binding]; other site 1045858006851 L3 interface [polypeptide binding]; other site 1045858006852 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1045858006853 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1045858006854 primosome assembly protein PriA; Validated; Region: PRK05580 1045858006855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1045858006856 ATP binding site [chemical binding]; other site 1045858006857 putative Mg++ binding site [ion binding]; other site 1045858006858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1045858006859 ATP-binding site [chemical binding]; other site 1045858006860 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1045858006861 DNA binding residues [nucleotide binding] 1045858006862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858006863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1045858006864 active site 1045858006865 phosphorylation site [posttranslational modification] 1045858006866 intermolecular recognition site; other site 1045858006867 dimerization interface [polypeptide binding]; other site 1045858006868 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1045858006869 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1045858006870 Substrate binding site; other site 1045858006871 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611 1045858006872 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1045858006873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1045858006874 active site 1045858006875 phosphorylation site [posttranslational modification] 1045858006876 intermolecular recognition site; other site 1045858006877 dimerization interface [polypeptide binding]; other site 1045858006878 CheB methylesterase; Region: CheB_methylest; pfam01339 1045858006879 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1045858006880 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1045858006881 putative active site [active] 1045858006882 catalytic triad [active] 1045858006883 putative dimer interface [polypeptide binding]; other site 1045858006884 Hemerythrin; Region: Hemerythrin; cd12107 1045858006885 Fe binding site [ion binding]; other site 1045858006886 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1045858006887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858006888 Walker A motif; other site 1045858006889 ATP binding site [chemical binding]; other site 1045858006890 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1045858006891 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1045858006892 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1045858006893 active site 1045858006894 HslU subunit interaction site [polypeptide binding]; other site 1045858006895 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006896 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006897 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006898 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006899 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006900 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006901 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006902 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858006903 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858006904 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1045858006905 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1045858006906 dimer interface [polypeptide binding]; other site 1045858006907 active site 1045858006908 metal binding site [ion binding]; metal-binding site 1045858006909 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1045858006910 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1045858006911 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1045858006912 active site 1045858006913 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1045858006914 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1045858006915 Smr domain; Region: Smr; pfam01713 1045858006916 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1045858006917 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1045858006918 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1045858006919 RNA binding site [nucleotide binding]; other site 1045858006920 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1045858006921 Walker A motif; other site 1045858006922 ATP binding site [chemical binding]; other site 1045858006923 Walker B motif; other site 1045858006924 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 1045858006925 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1045858006926 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1045858006927 alphaNTD homodimer interface [polypeptide binding]; other site 1045858006928 alphaNTD - beta interaction site [polypeptide binding]; other site 1045858006929 alphaNTD - beta' interaction site [polypeptide binding]; other site 1045858006930 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1045858006931 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 1045858006932 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1045858006933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045858006934 RNA binding surface [nucleotide binding]; other site 1045858006935 30S ribosomal protein S11; Validated; Region: PRK05309 1045858006936 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1045858006937 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1045858006938 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1045858006939 rRNA binding site [nucleotide binding]; other site 1045858006940 predicted 30S ribosome binding site; other site 1045858006941 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1045858006942 SecY translocase; Region: SecY; pfam00344 1045858006943 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1045858006944 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1045858006945 23S rRNA binding site [nucleotide binding]; other site 1045858006946 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1045858006947 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1045858006948 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1045858006949 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1045858006950 5S rRNA interface [nucleotide binding]; other site 1045858006951 23S rRNA interface [nucleotide binding]; other site 1045858006952 L5 interface [polypeptide binding]; other site 1045858006953 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1045858006954 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1045858006955 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1045858006956 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1045858006957 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1045858006958 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1045858006959 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1045858006960 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1045858006961 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1045858006962 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1045858006963 RNA binding site [nucleotide binding]; other site 1045858006964 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1045858006965 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1045858006966 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1045858006967 L23 interface [polypeptide binding]; other site 1045858006968 trigger factor interaction site; other site 1045858006969 23S rRNA interface [nucleotide binding]; other site 1045858006970 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1045858006971 23S rRNA interface [nucleotide binding]; other site 1045858006972 5S rRNA interface [nucleotide binding]; other site 1045858006973 putative antibiotic binding site [chemical binding]; other site 1045858006974 L25 interface [polypeptide binding]; other site 1045858006975 L27 interface [polypeptide binding]; other site 1045858006976 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1045858006977 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1045858006978 G-X-X-G motif; other site 1045858006979 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1045858006980 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1045858006981 putative translocon binding site; other site 1045858006982 protein-rRNA interface [nucleotide binding]; other site 1045858006983 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1045858006984 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1045858006985 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1045858006986 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1045858006987 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1045858006988 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1045858006989 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1045858006990 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1045858006991 elongation factor Tu; Reviewed; Region: PRK00049 1045858006992 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1045858006993 G1 box; other site 1045858006994 GEF interaction site [polypeptide binding]; other site 1045858006995 GTP/Mg2+ binding site [chemical binding]; other site 1045858006996 Switch I region; other site 1045858006997 G2 box; other site 1045858006998 G3 box; other site 1045858006999 Switch II region; other site 1045858007000 G4 box; other site 1045858007001 G5 box; other site 1045858007002 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1045858007003 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1045858007004 Antibiotic Binding Site [chemical binding]; other site 1045858007005 elongation factor G; Reviewed; Region: PRK00007 1045858007006 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1045858007007 G1 box; other site 1045858007008 putative GEF interaction site [polypeptide binding]; other site 1045858007009 GTP/Mg2+ binding site [chemical binding]; other site 1045858007010 Switch I region; other site 1045858007011 G2 box; other site 1045858007012 G3 box; other site 1045858007013 Switch II region; other site 1045858007014 G4 box; other site 1045858007015 G5 box; other site 1045858007016 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1045858007017 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1045858007018 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1045858007019 30S ribosomal protein S7; Validated; Region: PRK05302 1045858007020 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1045858007021 16S rRNA interaction site [nucleotide binding]; other site 1045858007022 streptomycin interaction site [chemical binding]; other site 1045858007023 23S rRNA interaction site [nucleotide binding]; other site 1045858007024 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1045858007025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1045858007026 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1045858007027 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1045858007028 metal binding site [ion binding]; metal-binding site 1045858007029 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1045858007030 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1045858007031 ligand binding site [chemical binding]; other site 1045858007032 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858007033 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858007034 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858007035 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858007036 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1045858007037 AAA domain; Region: AAA_21; pfam13304 1045858007038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858007039 ABC transporter signature motif; other site 1045858007040 Walker B; other site 1045858007041 D-loop; other site 1045858007042 H-loop/switch region; other site 1045858007043 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1045858007044 argininosuccinate lyase; Provisional; Region: PRK00855 1045858007045 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1045858007046 active sites [active] 1045858007047 tetramer interface [polypeptide binding]; other site 1045858007048 argininosuccinate synthase; Provisional; Region: PRK13820 1045858007049 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1045858007050 ANP binding site [chemical binding]; other site 1045858007051 Substrate Binding Site II [chemical binding]; other site 1045858007052 Substrate Binding Site I [chemical binding]; other site 1045858007053 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1045858007054 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1045858007055 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1045858007056 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1045858007057 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1045858007058 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1045858007059 flagellin; Provisional; Region: PRK12804 1045858007060 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1045858007061 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1045858007062 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1045858007063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007064 binding surface 1045858007065 TPR motif; other site 1045858007066 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1045858007067 Sporulation and spore germination; Region: Germane; pfam10646 1045858007068 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1045858007069 active site residue [active] 1045858007070 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858007071 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858007072 peptide binding site [polypeptide binding]; other site 1045858007073 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858007074 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858007075 peptide binding site [polypeptide binding]; other site 1045858007076 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858007077 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858007078 peptide binding site [polypeptide binding]; other site 1045858007079 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1045858007080 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1045858007081 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1045858007082 active site 1045858007083 NAD binding site [chemical binding]; other site 1045858007084 metal binding site [ion binding]; metal-binding site 1045858007085 RNase_H superfamily; Region: RNase_H_2; pfam13482 1045858007086 active site 1045858007087 catalytic site [active] 1045858007088 substrate binding site [chemical binding]; other site 1045858007089 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1045858007090 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1045858007091 active site 1045858007092 HIGH motif; other site 1045858007093 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1045858007094 KMSKS motif; other site 1045858007095 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1045858007096 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 1045858007097 TPR repeat; Region: TPR_11; pfam13414 1045858007098 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 1045858007099 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1045858007100 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1045858007101 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1045858007102 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1045858007103 active site 1045858007104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858007105 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1045858007106 FeS/SAM binding site; other site 1045858007107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858007108 Q-loop/lid; other site 1045858007109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858007110 ABC transporter signature motif; other site 1045858007111 Walker B; other site 1045858007112 D-loop; other site 1045858007113 H-loop/switch region; other site 1045858007114 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 1045858007115 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1045858007116 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1045858007117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858007118 FeS/SAM binding site; other site 1045858007119 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1045858007120 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1045858007121 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1045858007122 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1045858007123 putative NAD(P) binding site [chemical binding]; other site 1045858007124 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1045858007125 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1045858007126 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1045858007127 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1045858007128 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1045858007129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045858007130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858007131 Divergent AAA domain; Region: AAA_4; pfam04326 1045858007132 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1045858007133 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1045858007134 ApbE family; Region: ApbE; pfam02424 1045858007135 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858007136 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 1045858007137 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1045858007138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858007139 S-adenosylmethionine binding site [chemical binding]; other site 1045858007140 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1045858007141 Flagellin N-methylase; Region: FliB; pfam03692 1045858007142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858007143 Zn2+ binding site [ion binding]; other site 1045858007144 Mg2+ binding site [ion binding]; other site 1045858007145 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1045858007146 metal-binding site [ion binding] 1045858007147 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1045858007148 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1045858007149 active site 1045858007150 Int/Topo IB signature motif; other site 1045858007151 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1045858007152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045858007153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858007154 catalytic residue [active] 1045858007155 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1045858007156 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1045858007157 putative ligand binding site [chemical binding]; other site 1045858007158 putative NAD binding site [chemical binding]; other site 1045858007159 catalytic site [active] 1045858007160 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045858007161 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1045858007162 putative dimer interface [polypeptide binding]; other site 1045858007163 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1045858007164 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1045858007165 putative dimer interface [polypeptide binding]; other site 1045858007166 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1045858007167 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1045858007168 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1045858007169 biotin synthase; Region: bioB; TIGR00433 1045858007170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1045858007171 FeS/SAM binding site; other site 1045858007172 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1045858007173 AAA domain; Region: AAA_26; pfam13500 1045858007174 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1045858007175 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1045858007176 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1045858007177 inhibitor-cofactor binding pocket; inhibition site 1045858007178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858007179 catalytic residue [active] 1045858007180 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1045858007181 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1045858007182 peptide binding site [polypeptide binding]; other site 1045858007183 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1045858007184 N- and C-terminal domain interface [polypeptide binding]; other site 1045858007185 D-xylulose kinase; Region: XylB; TIGR01312 1045858007186 active site 1045858007187 MgATP binding site [chemical binding]; other site 1045858007188 catalytic site [active] 1045858007189 metal binding site [ion binding]; metal-binding site 1045858007190 xylulose binding site [chemical binding]; other site 1045858007191 homodimer interface [polypeptide binding]; other site 1045858007192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858007193 active site 1045858007194 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1045858007195 oligomerisation interface [polypeptide binding]; other site 1045858007196 mobile loop; other site 1045858007197 roof hairpin; other site 1045858007198 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 1045858007199 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1045858007200 SmpB-tmRNA interface; other site 1045858007201 Domain of unknown function (DUF305); Region: DUF305; cl17794 1045858007202 RimM N-terminal domain; Region: RimM; pfam01782 1045858007203 PRC-barrel domain; Region: PRC; pfam05239 1045858007204 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1045858007205 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1045858007206 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1045858007207 signal recognition particle protein; Provisional; Region: PRK10867 1045858007208 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1045858007209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1045858007210 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1045858007211 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1045858007212 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1045858007213 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1045858007214 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 1045858007215 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 1045858007216 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1045858007217 carboxyltransferase (CT) interaction site; other site 1045858007218 biotinylation site [posttranslational modification]; other site 1045858007219 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1045858007220 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1045858007221 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1045858007222 PsbP; Region: PsbP; cl03356 1045858007223 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1045858007224 Protein export membrane protein; Region: SecD_SecF; cl14618 1045858007225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1045858007226 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1045858007227 HlyD family secretion protein; Region: HlyD_3; pfam13437 1045858007228 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1045858007229 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007230 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007231 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007232 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007233 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007234 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007235 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007236 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007239 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007240 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007241 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858007242 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007243 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007244 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1045858007245 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1045858007246 putative active site [active] 1045858007247 PhoH-like protein; Region: PhoH; pfam02562 1045858007248 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1045858007249 active site 1045858007250 substrate binding site [chemical binding]; other site 1045858007251 trimer interface [polypeptide binding]; other site 1045858007252 CoA binding site [chemical binding]; other site 1045858007253 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1045858007254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1045858007255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1045858007256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1045858007257 dimerization interface [polypeptide binding]; other site 1045858007258 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1045858007259 active site 1045858007260 catalytic residues [active] 1045858007261 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1045858007262 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1045858007263 cofactor binding site; other site 1045858007264 DNA binding site [nucleotide binding] 1045858007265 substrate interaction site [chemical binding]; other site 1045858007266 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1045858007267 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1045858007268 additional DNA contacts [nucleotide binding]; other site 1045858007269 mismatch recognition site; other site 1045858007270 active site 1045858007271 zinc binding site [ion binding]; other site 1045858007272 DNA intercalation site [nucleotide binding]; other site 1045858007273 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1045858007274 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1045858007275 catalytic motif [active] 1045858007276 Zn binding site [ion binding]; other site 1045858007277 RibD C-terminal domain; Region: RibD_C; cl17279 1045858007278 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1045858007279 Lumazine binding domain; Region: Lum_binding; pfam00677 1045858007280 Lumazine binding domain; Region: Lum_binding; pfam00677 1045858007281 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1045858007282 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1045858007283 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1045858007284 dimerization interface [polypeptide binding]; other site 1045858007285 active site 1045858007286 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1045858007287 homopentamer interface [polypeptide binding]; other site 1045858007288 active site 1045858007289 Rubrerythrin [Energy production and conversion]; Region: COG1592 1045858007290 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1045858007291 binuclear metal center [ion binding]; other site 1045858007292 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 1045858007293 iron binding site [ion binding]; other site 1045858007294 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1045858007295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858007296 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1045858007297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007298 binding surface 1045858007299 TPR motif; other site 1045858007300 TPR repeat; Region: TPR_11; pfam13414 1045858007301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007302 binding surface 1045858007303 TPR motif; other site 1045858007304 TPR repeat; Region: TPR_11; pfam13414 1045858007305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007306 binding surface 1045858007307 TPR motif; other site 1045858007308 TPR repeat; Region: TPR_11; pfam13414 1045858007309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007310 binding surface 1045858007311 TPR motif; other site 1045858007312 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1045858007313 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1045858007314 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1045858007315 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1045858007316 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1045858007317 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1045858007318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858007319 Walker A motif; other site 1045858007320 ATP binding site [chemical binding]; other site 1045858007321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1045858007322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858007323 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045858007324 substrate binding pocket [chemical binding]; other site 1045858007325 membrane-bound complex binding site; other site 1045858007326 hinge residues; other site 1045858007327 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1045858007328 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1045858007329 putative active site [active] 1045858007330 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1045858007331 hypothetical protein; Reviewed; Region: PRK12497 1045858007332 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1045858007333 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1045858007334 Zn2+ binding site [ion binding]; other site 1045858007335 Mg2+ binding site [ion binding]; other site 1045858007336 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1045858007337 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1045858007338 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1045858007339 hypothetical protein; Region: PHA00684 1045858007340 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1045858007341 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1045858007342 Family of unknown function (DUF438); Region: DUF438; pfam04282 1045858007343 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1045858007344 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1045858007345 dimerization interface [polypeptide binding]; other site 1045858007346 putative active cleft [active] 1045858007347 TPR repeat; Region: TPR_11; pfam13414 1045858007348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007349 binding surface 1045858007350 TPR motif; other site 1045858007351 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1045858007352 TPR repeat; Region: TPR_11; pfam13414 1045858007353 TPR repeat; Region: TPR_11; pfam13414 1045858007354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007355 binding surface 1045858007356 TPR motif; other site 1045858007357 TPR repeat; Region: TPR_11; pfam13414 1045858007358 TPR repeat; Region: TPR_11; pfam13414 1045858007359 TPR repeat; Region: TPR_11; pfam13414 1045858007360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007361 binding surface 1045858007362 TPR motif; other site 1045858007363 TPR repeat; Region: TPR_11; pfam13414 1045858007364 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1045858007365 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1045858007366 Ligand binding site; other site 1045858007367 Putative Catalytic site; other site 1045858007368 DXD motif; other site 1045858007369 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 1045858007370 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 1045858007371 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1045858007372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007373 binding surface 1045858007374 TPR repeat; Region: TPR_11; pfam13414 1045858007375 TPR motif; other site 1045858007376 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1045858007377 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1045858007378 nucleotide binding pocket [chemical binding]; other site 1045858007379 K-X-D-G motif; other site 1045858007380 catalytic site [active] 1045858007381 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1045858007382 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1045858007383 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1045858007384 Dimer interface [polypeptide binding]; other site 1045858007385 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1045858007386 catalytic triad [active] 1045858007387 conserved cis-peptide bond; other site 1045858007388 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1045858007389 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1045858007390 proposed catalytic triad [active] 1045858007391 conserved cys residue [active] 1045858007392 Phage terminase large subunit; Region: Terminase_3; cl12054 1045858007393 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1045858007394 active site 1045858007395 intersubunit interactions; other site 1045858007396 catalytic residue [active] 1045858007397 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1045858007398 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1045858007399 active site 1045858007400 catalytic tetrad [active] 1045858007401 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1045858007402 active site 1045858007403 catalytic triad [active] 1045858007404 oxyanion hole [active] 1045858007405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1045858007406 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1045858007407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1045858007408 putative substrate translocation pore; other site 1045858007409 Rubrerythrin [Energy production and conversion]; Region: COG1592 1045858007410 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1045858007411 binuclear metal center [ion binding]; other site 1045858007412 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1045858007413 iron binding site [ion binding]; other site 1045858007414 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1045858007415 amphipathic channel; other site 1045858007416 Asn-Pro-Ala signature motifs; other site 1045858007417 glycerol kinase; Provisional; Region: glpK; PRK00047 1045858007418 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1045858007419 N- and C-terminal domain interface [polypeptide binding]; other site 1045858007420 active site 1045858007421 MgATP binding site [chemical binding]; other site 1045858007422 catalytic site [active] 1045858007423 metal binding site [ion binding]; metal-binding site 1045858007424 glycerol binding site [chemical binding]; other site 1045858007425 homotetramer interface [polypeptide binding]; other site 1045858007426 homodimer interface [polypeptide binding]; other site 1045858007427 FBP binding site [chemical binding]; other site 1045858007428 protein IIAGlc interface [polypeptide binding]; other site 1045858007429 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1045858007430 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1045858007431 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045858007432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1045858007433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1045858007434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1045858007435 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1045858007436 active site 1045858007437 Mn binding site [ion binding]; other site 1045858007438 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 1045858007439 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 1045858007440 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858007441 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858007442 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1045858007443 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1045858007444 putative active site [active] 1045858007445 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1045858007446 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1045858007447 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1045858007448 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1045858007449 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1045858007450 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1045858007451 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1045858007452 TPP-binding site [chemical binding]; other site 1045858007453 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1045858007454 dimer interface [polypeptide binding]; other site 1045858007455 PYR/PP interface [polypeptide binding]; other site 1045858007456 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1045858007457 TPP binding site [chemical binding]; other site 1045858007458 substrate binding site [chemical binding]; other site 1045858007459 Ferredoxin [Energy production and conversion]; Region: COG1146 1045858007460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007461 binding surface 1045858007462 TPR repeat; Region: TPR_11; pfam13414 1045858007463 TPR motif; other site 1045858007464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007465 binding surface 1045858007466 TPR motif; other site 1045858007467 TPR repeat; Region: TPR_11; pfam13414 1045858007468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007469 binding surface 1045858007470 TPR repeat; Region: TPR_11; pfam13414 1045858007471 TPR motif; other site 1045858007472 TPR repeat; Region: TPR_11; pfam13414 1045858007473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007474 binding surface 1045858007475 TPR motif; other site 1045858007476 TPR repeat; Region: TPR_11; pfam13414 1045858007477 TPR repeat; Region: TPR_11; pfam13414 1045858007478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007479 binding surface 1045858007480 TPR motif; other site 1045858007481 TPR repeat; Region: TPR_11; pfam13414 1045858007482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007483 binding surface 1045858007484 TPR motif; other site 1045858007485 TPR repeat; Region: TPR_11; pfam13414 1045858007486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007487 binding surface 1045858007488 TPR motif; other site 1045858007489 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1045858007490 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1045858007491 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1045858007492 peptidase T; Region: peptidase-T; TIGR01882 1045858007493 metal binding site [ion binding]; metal-binding site 1045858007494 dimer interface [polypeptide binding]; other site 1045858007495 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 1045858007496 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1045858007497 dimer interface [polypeptide binding]; other site 1045858007498 PYR/PP interface [polypeptide binding]; other site 1045858007499 TPP binding site [chemical binding]; other site 1045858007500 substrate binding site [chemical binding]; other site 1045858007501 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 1045858007502 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 1045858007503 TPP-binding site [chemical binding]; other site 1045858007504 putative dimer interface [polypeptide binding]; other site 1045858007505 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1045858007506 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 1045858007507 4Fe-4S binding domain; Region: Fer4; cl02805 1045858007508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858007509 dimerization interface [polypeptide binding]; other site 1045858007510 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858007511 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858007512 dimer interface [polypeptide binding]; other site 1045858007513 putative CheW interface [polypeptide binding]; other site 1045858007514 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1045858007515 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1045858007516 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1045858007517 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1045858007518 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1045858007519 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1045858007520 putative ribose interaction site [chemical binding]; other site 1045858007521 putative ADP binding site [chemical binding]; other site 1045858007522 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1045858007523 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1045858007524 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1045858007525 active site 1045858007526 Leucine rich repeat; Region: LRR_8; pfam13855 1045858007527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1045858007528 RNA binding surface [nucleotide binding]; other site 1045858007529 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1045858007530 pseudouridine synthase; Region: TIGR00093 1045858007531 active site 1045858007532 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1045858007533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1045858007534 Walker A motif; other site 1045858007535 ATP binding site [chemical binding]; other site 1045858007536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1045858007537 Walker B motif; other site 1045858007538 arginine finger; other site 1045858007539 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1045858007540 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1045858007541 Na2 binding site [ion binding]; other site 1045858007542 putative substrate binding site 1 [chemical binding]; other site 1045858007543 Na binding site 1 [ion binding]; other site 1045858007544 putative substrate binding site 2 [chemical binding]; other site 1045858007545 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1045858007546 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1045858007547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1045858007548 catalytic residue [active] 1045858007549 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1045858007550 V-type ATP synthase subunit K; Provisional; Region: PRK09621 1045858007551 V-type ATP synthase subunit I; Validated; Region: PRK05771 1045858007552 V-type ATP synthase subunit D; Provisional; Region: PRK02195 1045858007553 V-type ATP synthase subunit B; Provisional; Region: PRK02118 1045858007554 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1045858007555 Walker A motif homologous position; other site 1045858007556 Walker B motif; other site 1045858007557 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1045858007558 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1045858007559 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1045858007560 Walker A motif/ATP binding site; other site 1045858007561 Walker B motif; other site 1045858007562 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 1045858007563 V-type ATP synthase subunit E; Provisional; Region: PRK01005 1045858007564 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1045858007565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1045858007566 active site 1045858007567 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1045858007568 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1045858007569 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1045858007570 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1045858007571 Ligand binding site [chemical binding]; other site 1045858007572 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1045858007573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1045858007574 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1045858007575 FAD binding site [chemical binding]; other site 1045858007576 homotetramer interface [polypeptide binding]; other site 1045858007577 substrate binding pocket [chemical binding]; other site 1045858007578 catalytic base [active] 1045858007579 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1045858007580 dimer interaction site [polypeptide binding]; other site 1045858007581 substrate-binding tunnel; other site 1045858007582 active site 1045858007583 catalytic site [active] 1045858007584 substrate binding site [chemical binding]; other site 1045858007585 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1045858007586 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1045858007587 Coenzyme A transferase; Region: CoA_trans; smart00882 1045858007588 Coenzyme A transferase; Region: CoA_trans; cl17247 1045858007589 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 1045858007590 putative active site [active] 1045858007591 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1045858007592 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1045858007593 NAD(P) binding site [chemical binding]; other site 1045858007594 homodimer interface [polypeptide binding]; other site 1045858007595 substrate binding site [chemical binding]; other site 1045858007596 active site 1045858007597 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045858007598 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1045858007599 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1045858007600 GTP-binding protein LepA; Provisional; Region: PRK05433 1045858007601 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1045858007602 G1 box; other site 1045858007603 putative GEF interaction site [polypeptide binding]; other site 1045858007604 GTP/Mg2+ binding site [chemical binding]; other site 1045858007605 Switch I region; other site 1045858007606 G2 box; other site 1045858007607 G3 box; other site 1045858007608 Switch II region; other site 1045858007609 G4 box; other site 1045858007610 G5 box; other site 1045858007611 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1045858007612 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1045858007613 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1045858007614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858007615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045858007616 substrate binding pocket [chemical binding]; other site 1045858007617 membrane-bound complex binding site; other site 1045858007618 hinge residues; other site 1045858007619 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1045858007620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1045858007621 substrate binding pocket [chemical binding]; other site 1045858007622 membrane-bound complex binding site; other site 1045858007623 hinge residues; other site 1045858007624 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1045858007625 active pocket/dimerization site; other site 1045858007626 active site 1045858007627 phosphorylation site [posttranslational modification] 1045858007628 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1045858007629 MgtC family; Region: MgtC; pfam02308 1045858007630 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1045858007631 Walker A/P-loop; other site 1045858007632 ATP binding site [chemical binding]; other site 1045858007633 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1045858007634 ABC transporter signature motif; other site 1045858007635 Walker B; other site 1045858007636 D-loop; other site 1045858007637 H-loop/switch region; other site 1045858007638 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1045858007639 putative active site [active] 1045858007640 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007641 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007642 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007643 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007644 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007645 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1045858007646 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1045858007647 CoA binding domain; Region: CoA_binding; smart00881 1045858007648 NAD-dependent deacetylase; Provisional; Region: PRK00481 1045858007649 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1045858007650 Hemerythrin; Region: Hemerythrin; cd12107 1045858007651 Fe binding site [ion binding]; other site 1045858007652 Hemerythrin; Region: Hemerythrin; cd12107 1045858007653 Fe binding site [ion binding]; other site 1045858007654 enolase; Provisional; Region: eno; PRK00077 1045858007655 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1045858007656 dimer interface [polypeptide binding]; other site 1045858007657 metal binding site [ion binding]; metal-binding site 1045858007658 substrate binding pocket [chemical binding]; other site 1045858007659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1045858007660 active site 1045858007661 phosphorylation site [posttranslational modification] 1045858007662 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1045858007663 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1045858007664 Ligand binding site; other site 1045858007665 oligomer interface; other site 1045858007666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045858007667 catalytic core [active] 1045858007668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1045858007669 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1045858007670 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1045858007671 beta-galactosidase; Region: BGL; TIGR03356 1045858007672 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1045858007673 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1045858007674 active site turn [active] 1045858007675 phosphorylation site [posttranslational modification] 1045858007676 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1045858007677 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1045858007678 HPr interaction site; other site 1045858007679 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1045858007680 active site 1045858007681 phosphorylation site [posttranslational modification] 1045858007682 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1045858007683 CAT RNA binding domain; Region: CAT_RBD; smart01061 1045858007684 PRD domain; Region: PRD; pfam00874 1045858007685 PRD domain; Region: PRD; pfam00874 1045858007686 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1045858007687 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858007688 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007689 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007690 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007692 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007693 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007694 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007695 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007696 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1045858007697 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1045858007698 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1045858007699 protein binding site [polypeptide binding]; other site 1045858007700 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1045858007701 Catalytic dyad [active] 1045858007702 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1045858007703 active site 1045858007704 YcxB-like protein; Region: YcxB; pfam14317 1045858007705 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1045858007706 alanine racemase; Reviewed; Region: alr; PRK00053 1045858007707 active site 1045858007708 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1045858007709 dimer interface [polypeptide binding]; other site 1045858007710 substrate binding site [chemical binding]; other site 1045858007711 catalytic residues [active] 1045858007712 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858007713 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858007714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858007715 dimer interface [polypeptide binding]; other site 1045858007716 putative CheW interface [polypeptide binding]; other site 1045858007717 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1045858007718 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1045858007719 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1045858007720 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1045858007721 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1045858007722 hinge; other site 1045858007723 active site 1045858007724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007725 TPR repeat; Region: TPR_11; pfam13414 1045858007726 binding surface 1045858007727 TPR motif; other site 1045858007728 TPR repeat; Region: TPR_11; pfam13414 1045858007729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007730 binding surface 1045858007731 TPR motif; other site 1045858007732 TPR repeat; Region: TPR_11; pfam13414 1045858007733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007734 binding surface 1045858007735 TPR motif; other site 1045858007736 TPR repeat; Region: TPR_11; pfam13414 1045858007737 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1045858007738 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1045858007739 G1 box; other site 1045858007740 GTP/Mg2+ binding site [chemical binding]; other site 1045858007741 Switch I region; other site 1045858007742 G2 box; other site 1045858007743 Switch II region; other site 1045858007744 G3 box; other site 1045858007745 G4 box; other site 1045858007746 G5 box; other site 1045858007747 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1045858007748 G1 box; other site 1045858007749 GTP/Mg2+ binding site [chemical binding]; other site 1045858007750 Switch I region; other site 1045858007751 G2 box; other site 1045858007752 G3 box; other site 1045858007753 Switch II region; other site 1045858007754 G4 box; other site 1045858007755 Predicted membrane protein [Function unknown]; Region: COG0344 1045858007756 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1045858007757 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1045858007758 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1045858007759 metal ion-dependent adhesion site (MIDAS); other site 1045858007760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1045858007761 AAA domain; Region: AAA_21; pfam13304 1045858007762 Walker A/P-loop; other site 1045858007763 ATP binding site [chemical binding]; other site 1045858007764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007765 binding surface 1045858007766 TPR motif; other site 1045858007767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007768 TPR motif; other site 1045858007769 binding surface 1045858007770 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1045858007771 Chromate transporter; Region: Chromate_transp; pfam02417 1045858007772 Chromate transporter; Region: Chromate_transp; pfam02417 1045858007773 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1045858007774 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1045858007775 putative deacylase active site [active] 1045858007776 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1045858007777 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1045858007778 aspartate kinase; Reviewed; Region: PRK09034 1045858007779 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1045858007780 nucleotide binding site [chemical binding]; other site 1045858007781 substrate binding site [chemical binding]; other site 1045858007782 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1045858007783 allosteric regulatory residue; other site 1045858007784 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1045858007785 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1045858007786 active site 1045858007787 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1045858007788 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1045858007789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1045858007790 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1045858007791 active site 1045858007792 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1045858007793 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1045858007794 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1045858007795 Ligand binding site; other site 1045858007796 Putative Catalytic site; other site 1045858007797 DXD motif; other site 1045858007798 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1045858007799 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1045858007800 GatB domain; Region: GatB_Yqey; smart00845 1045858007801 cytosolic glyceraldehyde 3-phosphate dehydrogenase; Provisional; Region: PTZ00434 1045858007802 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1045858007803 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1045858007804 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1045858007805 Phosphoglycerate kinase; Region: PGK; pfam00162 1045858007806 substrate binding site [chemical binding]; other site 1045858007807 hinge regions; other site 1045858007808 ADP binding site [chemical binding]; other site 1045858007809 catalytic site [active] 1045858007810 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1045858007811 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1045858007812 heterotetramer interface [polypeptide binding]; other site 1045858007813 active site pocket [active] 1045858007814 cleavage site 1045858007815 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858007816 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858007817 putative acyltransferase; Provisional; Region: PRK05790 1045858007818 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1045858007819 dimer interface [polypeptide binding]; other site 1045858007820 active site 1045858007821 thiamine monophosphate kinase; Provisional; Region: PRK05731 1045858007822 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1045858007823 ATP binding site [chemical binding]; other site 1045858007824 dimerization interface [polypeptide binding]; other site 1045858007825 FMN-binding domain; Region: FMN_bind; cl01081 1045858007826 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1045858007827 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1045858007828 SLBB domain; Region: SLBB; pfam10531 1045858007829 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1045858007830 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1045858007831 active site 1045858007832 putative phosphate acyltransferase; Provisional; Region: PRK05331 1045858007833 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1045858007834 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1045858007835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858007836 S-adenosylmethionine binding site [chemical binding]; other site 1045858007837 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1045858007838 Cell division protein ZapA; Region: ZapA; pfam05164 1045858007839 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 1045858007840 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045858007841 Restriction endonuclease; Region: Mrr_cat; pfam04471 1045858007842 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1045858007843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1045858007844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1045858007845 homodimer interface [polypeptide binding]; other site 1045858007846 catalytic residue [active] 1045858007847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1045858007848 dimerization interface [polypeptide binding]; other site 1045858007849 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858007850 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1045858007851 dimer interface [polypeptide binding]; other site 1045858007852 putative CheW interface [polypeptide binding]; other site 1045858007853 HAMP domain; Region: HAMP; pfam00672 1045858007854 dimerization interface [polypeptide binding]; other site 1045858007855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858007856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858007857 dimer interface [polypeptide binding]; other site 1045858007858 putative CheW interface [polypeptide binding]; other site 1045858007859 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 1045858007860 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1045858007861 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1045858007862 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 1045858007863 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1045858007864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1045858007865 dimer interface [polypeptide binding]; other site 1045858007866 putative CheW interface [polypeptide binding]; other site 1045858007867 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1045858007868 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1045858007869 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1045858007870 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1045858007871 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1045858007872 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1045858007873 substrate binding site [chemical binding]; other site 1045858007874 glutamase interaction surface [polypeptide binding]; other site 1045858007875 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1045858007876 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1045858007877 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1045858007878 active site 1045858007879 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1045858007880 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1045858007881 dimer interface [polypeptide binding]; other site 1045858007882 anticodon binding site; other site 1045858007883 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1045858007884 homodimer interface [polypeptide binding]; other site 1045858007885 motif 1; other site 1045858007886 active site 1045858007887 motif 2; other site 1045858007888 GAD domain; Region: GAD; pfam02938 1045858007889 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1045858007890 active site 1045858007891 motif 3; other site 1045858007892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007893 TPR motif; other site 1045858007894 binding surface 1045858007895 TPR repeat; Region: TPR_11; pfam13414 1045858007896 TPR repeat; Region: TPR_11; pfam13414 1045858007897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007898 binding surface 1045858007899 TPR motif; other site 1045858007900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1045858007901 TPR motif; other site 1045858007902 binding surface 1045858007903 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1045858007904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1045858007905 motif II; other site 1045858007906 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 1045858007907 oligomer interface [polypeptide binding]; other site 1045858007908 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1045858007909 catalytic triad [active] 1045858007910 conserved cis-peptide bond; other site 1045858007911 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1045858007912 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1045858007913 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1045858007914 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1045858007916 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1045858007917 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1045858007918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1045858007919 S-adenosylmethionine binding site [chemical binding]; other site