-- dump date 20140619_004547 -- class Genbank::misc_feature -- table misc_feature_note -- id note 445985000001 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985000002 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985000003 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985000004 DUF276; Region: DUF276; pfam03434 445985000005 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985000006 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985000007 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985000008 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985000009 AAA domain; Region: AAA_13; pfam13166 445985000010 Mlp lipoprotein family; Region: Mlp; pfam03304 445985000011 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000012 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000013 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000015 P-loop; other site 445985000016 Magnesium ion binding site [ion binding]; other site 445985000017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000018 Magnesium ion binding site [ion binding]; other site 445985000019 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000020 transferase, transferring glycosyl groups; Region: PLN02939 445985000021 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985000022 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445985000023 active site 445985000024 catalytic residues [active] 445985000025 DNA binding site [nucleotide binding] 445985000026 Int/Topo IB signature motif; other site 445985000027 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985000028 Phage terminase large subunit; Region: Terminase_3; cl12054 445985000029 Terminase-like family; Region: Terminase_6; pfam03237 445985000030 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 445985000031 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985000032 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000033 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000034 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000035 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 445985000036 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985000037 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985000038 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985000039 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985000040 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985000041 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985000042 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985000043 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985000044 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985000045 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985000046 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985000047 DUF276; Region: DUF276; pfam03434 445985000048 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985000049 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985000050 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985000051 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985000052 ERF superfamily; Region: ERF; pfam04404 445985000053 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000054 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000055 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000056 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000057 P-loop; other site 445985000058 Magnesium ion binding site [ion binding]; other site 445985000059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000060 Magnesium ion binding site [ion binding]; other site 445985000061 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000062 phosphodiesterase; Provisional; Region: PRK12704 445985000063 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 445985000064 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985000065 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985000066 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445985000067 active site 445985000068 catalytic residues [active] 445985000069 DNA binding site [nucleotide binding] 445985000070 Int/Topo IB signature motif; other site 445985000071 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 445985000072 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985000073 Terminase-like family; Region: Terminase_6; pfam03237 445985000074 Phage terminase large subunit; Region: Terminase_3; cl12054 445985000075 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985000076 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000077 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000078 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985000079 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 445985000080 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985000081 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985000082 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985000083 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985000084 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985000085 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985000086 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985000087 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985000088 DUF276; Region: DUF276; pfam03434 445985000089 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985000090 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985000091 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985000092 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional; Region: PLN03229 445985000093 Mlp lipoprotein family; Region: Mlp; pfam03304 445985000094 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000095 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000096 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000097 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000098 P-loop; other site 445985000099 Magnesium ion binding site [ion binding]; other site 445985000100 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000101 Magnesium ion binding site [ion binding]; other site 445985000102 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000103 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 445985000104 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 445985000105 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985000106 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985000107 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445985000108 active site 445985000109 catalytic residues [active] 445985000110 DNA binding site [nucleotide binding] 445985000111 Int/Topo IB signature motif; other site 445985000112 Borrelia outer surface protein E; Region: OspE; pfam02471 445985000113 Erp protein C-terminus; Region: Erp_C; pfam06780 445985000114 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985000115 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985000116 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 445985000117 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 445985000118 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 445985000119 methionine cluster; other site 445985000120 active site 445985000121 phosphorylation site [posttranslational modification] 445985000122 metal binding site [ion binding]; metal-binding site 445985000123 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 445985000124 active site 445985000125 P-loop; other site 445985000126 phosphorylation site [posttranslational modification] 445985000127 Uncharacterized conserved protein [Function unknown]; Region: COG3589 445985000128 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 445985000129 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985000130 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985000131 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985000132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985000133 P-loop; other site 445985000134 Magnesium ion binding site [ion binding]; other site 445985000135 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445985000136 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985000137 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985000138 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985000139 peptide binding site [polypeptide binding]; other site 445985000140 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 445985000141 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 445985000142 active site 445985000143 GMP synthase; Reviewed; Region: guaA; PRK00074 445985000144 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 445985000145 AMP/PPi binding site [chemical binding]; other site 445985000146 candidate oxyanion hole; other site 445985000147 catalytic triad [active] 445985000148 potential glutamine specificity residues [chemical binding]; other site 445985000149 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 445985000150 ATP Binding subdomain [chemical binding]; other site 445985000151 Ligand Binding sites [chemical binding]; other site 445985000152 Dimerization subdomain; other site 445985000153 Lipoprotein; Region: Lipoprotein_6; pfam01441 445985000154 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 445985000155 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 445985000156 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 445985000157 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445985000158 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445985000159 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 445985000160 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 445985000161 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 445985000162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 445985000163 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 445985000164 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 445985000165 active site 445985000166 substrate binding site [chemical binding]; other site 445985000167 metal binding site [ion binding]; metal-binding site 445985000168 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 445985000169 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 445985000170 active site 445985000171 HIGH motif; other site 445985000172 dimer interface [polypeptide binding]; other site 445985000173 KMSKS motif; other site 445985000174 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 445985000175 Domain of unknown function DUF20; Region: UPF0118; pfam01594 445985000176 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 445985000177 TIGR00159 family protein; Region: TIGR00159 445985000178 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 445985000179 YbbR-like protein; Region: YbbR; pfam07949 445985000180 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 445985000181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 445985000182 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 445985000183 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 445985000184 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 445985000185 dimerization interface 3.5A [polypeptide binding]; other site 445985000186 active site 445985000187 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 445985000188 primosomal protein N' Region: priA; TIGR00595 445985000189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985000190 ATP binding site [chemical binding]; other site 445985000191 putative Mg++ binding site [ion binding]; other site 445985000192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985000193 nucleotide binding region [chemical binding]; other site 445985000194 ATP-binding site [chemical binding]; other site 445985000195 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 445985000196 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 445985000197 ATP-binding site [chemical binding]; other site 445985000198 Sugar specificity; other site 445985000199 Pyrimidine base specificity; other site 445985000200 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 445985000201 active site residue [active] 445985000202 Uncharacterized conserved protein [Function unknown]; Region: COG1284 445985000203 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 445985000204 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 445985000205 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 445985000206 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 445985000207 active site 445985000208 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent...; Region: Pyrophosphate_PFK; cd00765 445985000209 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 445985000210 active site 445985000211 pyrophosphate binding site [ion binding]; other site 445985000212 dimerization interface [polypeptide binding]; other site 445985000213 fructose-6-phosphate binding site; other site 445985000214 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 445985000215 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 445985000216 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 445985000217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985000218 Walker A motif; other site 445985000219 ATP binding site [chemical binding]; other site 445985000220 Walker B motif; other site 445985000221 arginine finger; other site 445985000222 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 445985000223 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 445985000224 RuvA N terminal domain; Region: RuvA_N; pfam01330 445985000225 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 445985000226 KIAA1430 homologue; Region: KIAA1430; pfam13879 445985000227 hypothetical protein; Validated; Region: PRK00110 445985000228 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 445985000229 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 445985000230 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 445985000231 homodimer interface [polypeptide binding]; other site 445985000232 NADP binding site [chemical binding]; other site 445985000233 substrate binding site [chemical binding]; other site 445985000234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 445985000235 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 445985000236 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 445985000237 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445985000238 Catalytic site [active] 445985000239 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445985000240 PEGA domain; Region: PEGA; pfam08308 445985000241 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 445985000242 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 445985000243 SmpB-tmRNA interface; other site 445985000244 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985000245 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 445985000246 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 445985000247 CAP-like domain; other site 445985000248 active site 445985000249 primary dimer interface [polypeptide binding]; other site 445985000250 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 445985000251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 445985000252 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 445985000253 anchoring element; other site 445985000254 dimer interface [polypeptide binding]; other site 445985000255 ATP binding site [chemical binding]; other site 445985000256 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 445985000257 active site 445985000258 putative metal-binding site [ion binding]; other site 445985000259 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 445985000260 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 445985000261 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 445985000262 putative acyl-acceptor binding pocket; other site 445985000263 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 445985000264 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 445985000265 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 445985000266 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 445985000267 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 445985000268 PhoU domain; Region: PhoU; pfam01895 445985000269 PhoU domain; Region: PhoU; pfam01895 445985000270 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445985000271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985000272 Walker A/P-loop; other site 445985000273 ATP binding site [chemical binding]; other site 445985000274 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445985000275 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 445985000276 ABC transporter signature motif; other site 445985000277 Walker B; other site 445985000278 D-loop; other site 445985000279 H-loop/switch region; other site 445985000280 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 445985000281 RNA/DNA hybrid binding site [nucleotide binding]; other site 445985000282 active site 445985000283 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 445985000284 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 445985000285 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 445985000286 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 445985000287 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 445985000288 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 445985000289 ligand binding site [chemical binding]; other site 445985000290 active site 445985000291 UGI interface [polypeptide binding]; other site 445985000292 catalytic site [active] 445985000293 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 445985000294 triosephosphate isomerase; Provisional; Region: PRK14565 445985000295 substrate binding site [chemical binding]; other site 445985000296 dimer interface [polypeptide binding]; other site 445985000297 catalytic triad [active] 445985000298 Phosphoglycerate kinase; Region: PGK; pfam00162 445985000299 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 445985000300 substrate binding site [chemical binding]; other site 445985000301 hinge regions; other site 445985000302 ADP binding site [chemical binding]; other site 445985000303 catalytic site [active] 445985000304 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 445985000305 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 445985000306 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 445985000307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000308 binding surface 445985000309 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985000310 TPR motif; other site 445985000311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000312 TPR motif; other site 445985000313 binding surface 445985000314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000315 binding surface 445985000316 TPR motif; other site 445985000317 TPR repeat; Region: TPR_11; pfam13414 445985000318 FOG: CBS domain [General function prediction only]; Region: COG0517 445985000319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 445985000320 Transporter associated domain; Region: CorC_HlyC; smart01091 445985000321 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 445985000322 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 445985000323 catalytic residues [active] 445985000324 RNA methyltransferase, RsmE family; Region: TIGR00046 445985000325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 445985000326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 445985000327 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 445985000328 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 445985000329 PASTA domain; Region: PASTA; smart00740 445985000330 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 445985000331 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 445985000332 putative active site [active] 445985000333 substrate binding site [chemical binding]; other site 445985000334 putative cosubstrate binding site; other site 445985000335 catalytic site [active] 445985000336 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 445985000337 substrate binding site [chemical binding]; other site 445985000338 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 445985000339 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 445985000340 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 445985000341 active site 445985000342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445985000343 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 445985000344 active site 445985000345 motif I; other site 445985000346 motif II; other site 445985000347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 445985000348 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 445985000349 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 445985000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 445985000351 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 445985000352 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 445985000353 This domain is found in peptide chain release factors; Region: PCRF; smart00937 445985000354 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 445985000355 RF-1 domain; Region: RF-1; pfam00472 445985000356 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 445985000357 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445985000358 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 445985000359 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 445985000360 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 445985000361 Walker A/P-loop; other site 445985000362 ATP binding site [chemical binding]; other site 445985000363 Q-loop/lid; other site 445985000364 ABC transporter signature motif; other site 445985000365 Walker B; other site 445985000366 D-loop; other site 445985000367 H-loop/switch region; other site 445985000368 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 445985000369 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 445985000370 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 445985000371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 445985000372 catalytic residue [active] 445985000373 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 445985000374 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 445985000375 active site 445985000376 trimerization site [polypeptide binding]; other site 445985000377 Mg chelatase-related protein; Region: TIGR00368 445985000378 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 445985000379 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 445985000380 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 445985000381 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 445985000382 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445985000383 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 445985000384 NAD binding site [chemical binding]; other site 445985000385 dimer interface [polypeptide binding]; other site 445985000386 substrate binding site [chemical binding]; other site 445985000387 GTP-binding protein LepA; Provisional; Region: PRK05433 445985000388 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 445985000389 Switch I region; other site 445985000390 G2 box; other site 445985000391 putative GEF interaction site [polypeptide binding]; other site 445985000392 G3 box; other site 445985000393 Switch II region; other site 445985000394 GTP/Mg2+ binding site [chemical binding]; other site 445985000395 G4 box; other site 445985000396 G5 box; other site 445985000397 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 445985000398 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 445985000399 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 445985000400 V-type ATP synthase subunit K; Validated; Region: PRK06649 445985000401 V-type ATP synthase subunit D; Provisional; Region: PRK02195 445985000402 V-type ATP synthase subunit B; Provisional; Region: PRK02118 445985000403 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445985000404 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 445985000405 Walker A motif homologous position; other site 445985000406 Walker B motif; other site 445985000407 V-type ATP synthase subunit A; Provisional; Region: PRK04192 445985000408 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445985000409 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 445985000410 Walker A motif/ATP binding site; other site 445985000411 Walker B motif; other site 445985000412 V-type ATP synthase subunit E; Provisional; Region: PRK01558 445985000413 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 445985000414 MutS2 family protein; Region: mutS2; TIGR01069 445985000415 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 445985000416 Walker A/P-loop; other site 445985000417 ATP binding site [chemical binding]; other site 445985000418 Q-loop/lid; other site 445985000419 ABC transporter signature motif; other site 445985000420 Walker B; other site 445985000421 D-loop; other site 445985000422 H-loop/switch region; other site 445985000423 Smr domain; Region: Smr; pfam01713 445985000424 ribosome small subunit-dependent GTPase A; Region: TIGR00157 445985000425 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 445985000426 GTPase/Zn-binding domain interface [polypeptide binding]; other site 445985000427 GTP/Mg2+ binding site [chemical binding]; other site 445985000428 G4 box; other site 445985000429 G5 box; other site 445985000430 G1 box; other site 445985000431 Switch I region; other site 445985000432 G2 box; other site 445985000433 G3 box; other site 445985000434 Switch II region; other site 445985000435 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 445985000436 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 445985000437 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 445985000438 putative dimer interface [polypeptide binding]; other site 445985000439 putative anticodon binding site; other site 445985000440 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 445985000441 homodimer interface [polypeptide binding]; other site 445985000442 motif 1; other site 445985000443 motif 2; other site 445985000444 active site 445985000445 motif 3; other site 445985000446 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 445985000447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445985000448 active site 445985000449 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 445985000450 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 445985000451 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 445985000452 protein binding site [polypeptide binding]; other site 445985000453 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 445985000454 protein binding site [polypeptide binding]; other site 445985000455 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 445985000456 active site 445985000457 Tetratricopeptide repeat; Region: TPR_12; pfam13424 445985000458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000459 binding surface 445985000460 TPR motif; other site 445985000461 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 445985000462 putative RNA binding site [nucleotide binding]; other site 445985000463 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 445985000464 SurA N-terminal domain; Region: SurA_N; pfam09312 445985000465 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 445985000466 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 445985000467 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 445985000468 dimer interface [polypeptide binding]; other site 445985000469 active site 445985000470 replicative DNA helicase; Region: DnaB; TIGR00665 445985000471 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 445985000472 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 445985000473 Walker A motif; other site 445985000474 ATP binding site [chemical binding]; other site 445985000475 Walker B motif; other site 445985000476 DNA binding loops [nucleotide binding] 445985000477 ribosomal protein L9; Region: L9; TIGR00158 445985000478 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 445985000479 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 445985000480 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 445985000481 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 445985000482 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 445985000483 dimer interface [polypeptide binding]; other site 445985000484 ssDNA binding site [nucleotide binding]; other site 445985000485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445985000486 ribosomal protein S6; Region: S6; TIGR00166 445985000487 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 445985000488 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 445985000489 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 445985000490 active site turn [active] 445985000491 phosphorylation site [posttranslational modification] 445985000492 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 445985000493 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 445985000494 RIP metalloprotease RseP; Region: TIGR00054 445985000495 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 445985000496 active site 445985000497 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 445985000498 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 445985000499 protein binding site [polypeptide binding]; other site 445985000500 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 445985000501 putative substrate binding region [chemical binding]; other site 445985000502 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 445985000503 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 445985000504 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14837 445985000505 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 445985000506 catalytic residue [active] 445985000507 putative FPP diphosphate binding site; other site 445985000508 putative FPP binding hydrophobic cleft; other site 445985000509 dimer interface [polypeptide binding]; other site 445985000510 putative IPP diphosphate binding site; other site 445985000511 ribosome recycling factor; Reviewed; Region: frr; PRK00083 445985000512 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 445985000513 hinge region; other site 445985000514 translation elongation factor Ts; Region: tsf; TIGR00116 445985000515 Elongation factor TS; Region: EF_TS; pfam00889 445985000516 Elongation factor TS; Region: EF_TS; pfam00889 445985000517 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 445985000518 rRNA interaction site [nucleotide binding]; other site 445985000519 S8 interaction site; other site 445985000520 putative laminin-1 binding site; other site 445985000521 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 445985000522 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 445985000523 RNA binding site [nucleotide binding]; other site 445985000524 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 445985000525 RNA binding site [nucleotide binding]; other site 445985000526 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 445985000527 RNA binding site [nucleotide binding]; other site 445985000528 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 445985000529 RNA binding site [nucleotide binding]; other site 445985000530 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 445985000531 RNA binding site [nucleotide binding]; other site 445985000532 cytidylate kinase; Region: cmk; TIGR00017 445985000533 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 445985000534 CMP-binding site; other site 445985000535 The sites determining sugar specificity; other site 445985000536 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 445985000537 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445985000538 RNA binding surface [nucleotide binding]; other site 445985000539 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 445985000540 active site 445985000541 ScpA/B protein; Region: ScpA_ScpB; cl00598 445985000542 recombinase A; Provisional; Region: recA; PRK09354 445985000543 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 445985000544 hexamer interface [polypeptide binding]; other site 445985000545 Walker A motif; other site 445985000546 ATP binding site [chemical binding]; other site 445985000547 Walker B motif; other site 445985000548 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 445985000549 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 445985000550 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 445985000551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000552 binding surface 445985000553 TPR motif; other site 445985000554 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985000555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000556 TPR motif; other site 445985000557 binding surface 445985000558 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 445985000559 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 445985000560 dimer interface [polypeptide binding]; other site 445985000561 motif 1; other site 445985000562 active site 445985000563 motif 2; other site 445985000564 motif 3; other site 445985000565 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 445985000566 anticodon binding site; other site 445985000567 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 445985000568 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 445985000569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 445985000570 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 445985000571 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 445985000572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 445985000573 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 445985000574 acyl-activating enzyme (AAE) consensus motif; other site 445985000575 putative AMP binding site [chemical binding]; other site 445985000576 putative active site [active] 445985000577 putative CoA binding site [chemical binding]; other site 445985000578 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 445985000579 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 445985000580 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 445985000581 lipoyl-biotinyl attachment site [posttranslational modification]; other site 445985000582 HlyD family secretion protein; Region: HlyD_3; pfam13437 445985000583 Outer membrane efflux protein; Region: OEP; pfam02321 445985000584 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 445985000585 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 445985000586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985000587 dimer interface [polypeptide binding]; other site 445985000588 conserved gate region; other site 445985000589 putative PBP binding loops; other site 445985000590 ABC-ATPase subunit interface; other site 445985000591 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 445985000592 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 445985000593 Walker A/P-loop; other site 445985000594 ATP binding site [chemical binding]; other site 445985000595 Q-loop/lid; other site 445985000596 ABC transporter signature motif; other site 445985000597 Walker B; other site 445985000598 D-loop; other site 445985000599 H-loop/switch region; other site 445985000600 flagellin; Provisional; Region: PRK12803 445985000601 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 445985000602 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 445985000603 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 445985000604 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 445985000605 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 445985000606 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 445985000607 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 445985000608 active site 445985000609 dimer interface [polypeptide binding]; other site 445985000610 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 445985000611 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 445985000612 active site 445985000613 trimer interface [polypeptide binding]; other site 445985000614 allosteric site; other site 445985000615 active site lid [active] 445985000616 hexamer (dimer of trimers) interface [polypeptide binding]; other site 445985000617 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 445985000618 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 445985000619 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 445985000620 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 445985000621 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 445985000622 SEC-C motif; Region: SEC-C; pfam02810 445985000623 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 445985000624 alanine racemase; Region: alr; TIGR00492 445985000625 active site 445985000626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 445985000627 dimer interface [polypeptide binding]; other site 445985000628 substrate binding site [chemical binding]; other site 445985000629 catalytic residues [active] 445985000630 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 445985000631 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 445985000632 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 445985000633 Uncharacterized conserved protein [Function unknown]; Region: COG1306 445985000634 4-alpha-glucanotransferase; Region: malQ; TIGR00217 445985000635 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 445985000636 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445985000637 ligand binding site [chemical binding]; other site 445985000638 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 445985000639 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 445985000640 rRNA binding site [nucleotide binding]; other site 445985000641 predicted 30S ribosome binding site; other site 445985000642 Oxygen tolerance; Region: BatD; pfam13584 445985000643 TPR repeat; Region: TPR_11; pfam13414 445985000644 Bacterial SH3 domain homologues; Region: SH3b; smart00287 445985000645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000646 TPR repeat; Region: TPR_11; pfam13414 445985000647 binding surface 445985000648 TPR motif; other site 445985000649 TPR repeat; Region: TPR_11; pfam13414 445985000650 von Willebrand factor type A domain; Region: VWA_2; pfam13519 445985000651 metal ion-dependent adhesion site (MIDAS); other site 445985000652 Aerotolerance regulator N-terminal; Region: BatA; cl06567 445985000653 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 445985000654 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 445985000655 metal ion-dependent adhesion site (MIDAS); other site 445985000656 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 445985000657 Protein of unknown function DUF58; Region: DUF58; pfam01882 445985000658 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 445985000659 MoxR-like ATPases [General function prediction only]; Region: COG0714 445985000660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985000661 Walker A motif; other site 445985000662 ATP binding site [chemical binding]; other site 445985000663 Walker B motif; other site 445985000664 arginine finger; other site 445985000665 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 445985000666 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 445985000667 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 445985000668 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 445985000669 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 445985000670 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 445985000671 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 445985000672 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 445985000673 trmE is a tRNA modification GTPase; Region: trmE; cd04164 445985000674 G1 box; other site 445985000675 GTP/Mg2+ binding site [chemical binding]; other site 445985000676 Switch I region; other site 445985000677 G2 box; other site 445985000678 Switch II region; other site 445985000679 G3 box; other site 445985000680 G4 box; other site 445985000681 G5 box; other site 445985000682 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 445985000683 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 445985000684 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 445985000685 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 445985000686 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 445985000687 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 445985000688 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 445985000689 flagellar assembly protein FliW; Provisional; Region: PRK13285 445985000690 carbon storage regulator (csrA); Region: csrA; TIGR00202 445985000691 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 445985000692 Glycoprotease family; Region: Peptidase_M22; pfam00814 445985000693 tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150 445985000694 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 445985000695 23S rRNA binding site [nucleotide binding]; other site 445985000696 L21 binding site [polypeptide binding]; other site 445985000697 L13 binding site [polypeptide binding]; other site 445985000698 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 445985000699 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 445985000700 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 445985000701 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 445985000702 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 445985000703 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 445985000704 active site 445985000705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 445985000706 binding surface 445985000707 TPR motif; other site 445985000708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000709 binding surface 445985000710 TPR repeat; Region: TPR_11; pfam13414 445985000711 TPR motif; other site 445985000712 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 445985000713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000714 binding surface 445985000715 TPR motif; other site 445985000716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000717 binding surface 445985000718 TPR motif; other site 445985000719 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985000720 peptide chain release factor 1; Validated; Region: prfA; PRK00591 445985000721 This domain is found in peptide chain release factors; Region: PCRF; smart00937 445985000722 RF-1 domain; Region: RF-1; pfam00472 445985000723 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 445985000724 HD domain; Region: HD_4; pfam13328 445985000725 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 445985000726 synthetase active site [active] 445985000727 NTP binding site [chemical binding]; other site 445985000728 metal binding site [ion binding]; metal-binding site 445985000729 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 445985000730 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 445985000731 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 445985000732 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 445985000733 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 445985000734 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445985000735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985000736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985000737 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 445985000738 Domain of unknown function DUF21; Region: DUF21; pfam01595 445985000739 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 445985000740 Transporter associated domain; Region: CorC_HlyC; smart01091 445985000741 HflK protein; Region: hflK; TIGR01933 445985000742 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 445985000743 HflC protein; Region: hflC; TIGR01932 445985000744 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 445985000745 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 445985000746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445985000747 S-adenosylmethionine binding site [chemical binding]; other site 445985000748 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 445985000749 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 445985000750 active site 445985000751 tetramer interface; other site 445985000752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000753 binding surface 445985000754 TPR motif; other site 445985000755 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985000756 TPR repeat; Region: TPR_11; pfam13414 445985000757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000758 TPR motif; other site 445985000759 TPR repeat; Region: TPR_11; pfam13414 445985000760 binding surface 445985000761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000762 binding surface 445985000763 TPR repeat; Region: TPR_11; pfam13414 445985000764 TPR motif; other site 445985000765 TPR repeat; Region: TPR_11; pfam13414 445985000766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000767 binding surface 445985000768 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985000769 TPR motif; other site 445985000770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000771 TPR motif; other site 445985000772 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985000773 binding surface 445985000774 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 445985000775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985000776 Mg2+ binding site [ion binding]; other site 445985000777 G-X-G motif; other site 445985000778 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 445985000779 ATP binding site [chemical binding]; other site 445985000780 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 445985000781 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 445985000782 translation elongation factor P; Region: efp; TIGR00038 445985000783 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 445985000784 RNA binding site [nucleotide binding]; other site 445985000785 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 445985000786 RNA binding site [nucleotide binding]; other site 445985000787 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 445985000788 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 445985000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985000790 dimer interface [polypeptide binding]; other site 445985000791 conserved gate region; other site 445985000792 putative PBP binding loops; other site 445985000793 ABC-ATPase subunit interface; other site 445985000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 445985000795 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 445985000796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985000797 dimer interface [polypeptide binding]; other site 445985000798 conserved gate region; other site 445985000799 putative PBP binding loops; other site 445985000800 ABC-ATPase subunit interface; other site 445985000801 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14273 445985000802 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 445985000803 Walker A/P-loop; other site 445985000804 ATP binding site [chemical binding]; other site 445985000805 Q-loop/lid; other site 445985000806 ABC transporter signature motif; other site 445985000807 Walker B; other site 445985000808 D-loop; other site 445985000809 H-loop/switch region; other site 445985000810 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 445985000811 ZIP Zinc transporter; Region: Zip; pfam02535 445985000812 alanyl-tRNA synthetase; Provisional; Region: PRK01584 445985000813 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 445985000814 motif 1; other site 445985000815 active site 445985000816 motif 2; other site 445985000817 motif 3; other site 445985000818 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 445985000819 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 445985000820 FliG C-terminal domain; Region: FliG_C; pfam01706 445985000821 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 445985000822 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 445985000823 putative active site [active] 445985000824 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 445985000825 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 445985000826 FMN binding site [chemical binding]; other site 445985000827 active site 445985000828 catalytic residues [active] 445985000829 substrate binding site [chemical binding]; other site 445985000830 seryl-tRNA synthetase; Region: serS; TIGR00414 445985000831 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 445985000832 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 445985000833 dimer interface [polypeptide binding]; other site 445985000834 active site 445985000835 motif 1; other site 445985000836 motif 2; other site 445985000837 motif 3; other site 445985000838 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 445985000839 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 445985000840 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985000841 Peptidase M16C associated; Region: M16C_assoc; pfam08367 445985000842 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985000843 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 445985000844 transcription termination factor Rho; Region: rho; TIGR00767 445985000845 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 445985000846 RNA binding site [nucleotide binding]; other site 445985000847 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 445985000848 multimer interface [polypeptide binding]; other site 445985000849 Walker A motif; other site 445985000850 ATP binding site [chemical binding]; other site 445985000851 Walker B motif; other site 445985000852 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 445985000853 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 445985000854 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 445985000855 IHF dimer interface [polypeptide binding]; other site 445985000856 IHF - DNA interface [nucleotide binding]; other site 445985000857 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 445985000858 GTP-binding protein YchF; Reviewed; Region: PRK09601 445985000859 YchF GTPase; Region: YchF; cd01900 445985000860 G1 box; other site 445985000861 GTP/Mg2+ binding site [chemical binding]; other site 445985000862 Switch I region; other site 445985000863 G2 box; other site 445985000864 Switch II region; other site 445985000865 G3 box; other site 445985000866 G4 box; other site 445985000867 G5 box; other site 445985000868 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 445985000869 TPR repeat; Region: TPR_11; pfam13414 445985000870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000871 TPR motif; other site 445985000872 binding surface 445985000873 Uncharacterized conserved protein [Function unknown]; Region: COG3391 445985000874 Uncharacterized conserved protein [Function unknown]; Region: COG3391 445985000875 von Willebrand factor type A domain; Region: VWA_2; pfam13519 445985000876 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 445985000877 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 445985000878 Substrate-binding site [chemical binding]; other site 445985000879 Substrate specificity [chemical binding]; other site 445985000880 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 445985000881 amphipathic channel; other site 445985000882 Asn-Pro-Ala signature motifs; other site 445985000883 glycerol kinase; Provisional; Region: glpK; PRK00047 445985000884 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 445985000885 N- and C-terminal domain interface [polypeptide binding]; other site 445985000886 active site 445985000887 MgATP binding site [chemical binding]; other site 445985000888 catalytic site [active] 445985000889 metal binding site [ion binding]; metal-binding site 445985000890 glycerol binding site [chemical binding]; other site 445985000891 homotetramer interface [polypeptide binding]; other site 445985000892 homodimer interface [polypeptide binding]; other site 445985000893 FBP binding site [chemical binding]; other site 445985000894 protein IIAGlc interface [polypeptide binding]; other site 445985000895 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 445985000896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 445985000897 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 445985000898 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 445985000899 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445985000900 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985000901 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 445985000902 active site 445985000903 dimerization interface [polypeptide binding]; other site 445985000904 oligoendopeptidase F; Region: pepF; TIGR00181 445985000905 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 445985000906 active site 445985000907 Zn binding site [ion binding]; other site 445985000908 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 445985000909 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 445985000910 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 445985000911 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 445985000912 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 445985000913 HIGH motif; other site 445985000914 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 445985000915 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985000916 active site 445985000917 KMSKS motif; other site 445985000918 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 445985000919 tRNA binding surface [nucleotide binding]; other site 445985000920 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 445985000921 Found in ATP-dependent protease La (LON); Region: LON; smart00464 445985000922 ATP-dependent protease La; Region: lon; TIGR00763 445985000923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985000924 Walker A motif; other site 445985000925 ATP binding site [chemical binding]; other site 445985000926 Walker B motif; other site 445985000927 arginine finger; other site 445985000928 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 445985000929 DHH family; Region: DHH; pfam01368 445985000930 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 445985000931 DHHA1 domain; Region: DHHA1; pfam02272 445985000932 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445985000933 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985000934 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 445985000935 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 445985000936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 445985000937 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 445985000938 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 445985000939 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 445985000940 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 445985000941 N-acetyl-D-glucosamine binding site [chemical binding]; other site 445985000942 catalytic residue [active] 445985000943 TPR repeat; Region: TPR_11; pfam13414 445985000944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985000945 TPR motif; other site 445985000946 binding surface 445985000947 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445985000948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985000949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985000950 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985000951 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 445985000952 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445985000953 Catalytic site [active] 445985000954 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 445985000955 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 445985000956 nucleotide binding site [chemical binding]; other site 445985000957 putative NEF/HSP70 interaction site [polypeptide binding]; other site 445985000958 SBD interface [polypeptide binding]; other site 445985000959 Uncharacterized conserved protein [Function unknown]; Region: COG1315 445985000960 Integral peroxisomal membrane peroxin; Region: Pex24p; pfam06398 445985000961 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 445985000962 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 445985000963 P-loop; other site 445985000964 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 445985000965 Protein of unknown function, DUF258; Region: DUF258; pfam03193 445985000966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445985000967 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 445985000968 FHIPEP family; Region: FHIPEP; pfam00771 445985000969 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 445985000970 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 445985000971 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 445985000972 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 445985000973 flagellar biosynthetic protein FliP; Region: fliP; TIGR01103 445985000974 flagellar biosynthesis protein FliZ; Provisional; Region: PRK13414 445985000975 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 445985000976 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 445985000977 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 445985000978 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK06654 445985000979 flagellar motor protein MotB; Validated; Region: motB; PRK06667 445985000980 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 445985000981 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445985000982 ligand binding site [chemical binding]; other site 445985000983 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 445985000984 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 445985000985 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 445985000986 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 445985000987 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 445985000988 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 445985000989 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 445985000990 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 445985000991 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 445985000992 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 445985000993 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 445985000994 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445985000995 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 445985000996 Walker A motif; other site 445985000997 ATP binding site [chemical binding]; other site 445985000998 Walker B motif; other site 445985000999 flagellar assembly protein H; Validated; Region: fliH; PRK06669 445985001000 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 445985001001 Flagellar assembly protein FliH; Region: FliH; pfam02108 445985001002 flagellar motor switch protein FliG; Region: fliG; TIGR00207 445985001003 FliG C-terminal domain; Region: FliG_C; pfam01706 445985001004 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 445985001005 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 445985001006 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 445985001007 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01482 445985001008 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 445985001009 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 445985001010 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 445985001011 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 445985001012 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 445985001013 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 445985001014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985001015 Walker A motif; other site 445985001016 ATP binding site [chemical binding]; other site 445985001017 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 445985001018 Walker B motif; other site 445985001019 arginine finger; other site 445985001020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 445985001021 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 445985001022 active site 445985001023 HslU subunit interaction site [polypeptide binding]; other site 445985001024 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 445985001025 DNA protecting protein DprA; Region: dprA; TIGR00732 445985001026 TPR repeat; Region: TPR_11; pfam13414 445985001027 Tetratricopeptide repeat; Region: TPR_1; pfam00515 445985001028 binding surface 445985001029 TPR motif; other site 445985001030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001031 binding surface 445985001032 TPR motif; other site 445985001033 cell division protein FtsZ; Validated; Region: PRK09330 445985001034 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 445985001035 nucleotide binding site [chemical binding]; other site 445985001036 SulA interaction site; other site 445985001037 cell division protein FtsA; Region: ftsA; TIGR01174 445985001038 Cell division protein FtsA; Region: FtsA; smart00842 445985001039 Cell division protein FtsA; Region: FtsA; pfam14450 445985001040 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 445985001041 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 445985001042 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 445985001043 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 445985001044 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 445985001045 Mg++ binding site [ion binding]; other site 445985001046 putative catalytic motif [active] 445985001047 putative substrate binding site [chemical binding]; other site 445985001048 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445985001049 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 445985001050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985001051 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985001052 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 445985001053 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 445985001054 ATP-NAD kinase; Region: NAD_kinase; pfam01513 445985001055 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 445985001056 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 445985001057 putative CheA interaction surface; other site 445985001058 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 445985001059 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 445985001060 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 445985001061 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 445985001062 substrate binding pocket [chemical binding]; other site 445985001063 chain length determination region; other site 445985001064 substrate-Mg2+ binding site; other site 445985001065 catalytic residues [active] 445985001066 aspartate-rich region 1; other site 445985001067 active site lid residues [active] 445985001068 aspartate-rich region 2; other site 445985001069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001070 binding surface 445985001071 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985001072 TPR motif; other site 445985001073 Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079 445985001074 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985001075 TM-ABC transporter signature motif; other site 445985001076 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 445985001077 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 445985001078 Walker A/P-loop; other site 445985001079 ATP binding site [chemical binding]; other site 445985001080 Q-loop/lid; other site 445985001081 ABC transporter signature motif; other site 445985001082 Walker B; other site 445985001083 D-loop; other site 445985001084 H-loop/switch region; other site 445985001085 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001086 Basic membrane protein; Region: Bmp; pfam02608 445985001087 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 445985001088 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445985001089 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 445985001090 metal ion-dependent adhesion site (MIDAS); other site 445985001091 Tetratricopeptide repeat; Region: TPR_12; pfam13424 445985001092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001093 binding surface 445985001094 TPR motif; other site 445985001095 Phosphate acyltransferases; Region: PlsC; smart00563 445985001096 putative acyl-acceptor binding pocket; other site 445985001097 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985001098 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985001099 peptide binding site [polypeptide binding]; other site 445985001100 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985001101 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985001102 peptide binding site [polypeptide binding]; other site 445985001103 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 445985001104 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985001105 peptide binding site [polypeptide binding]; other site 445985001106 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 445985001107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985001108 dimer interface [polypeptide binding]; other site 445985001109 conserved gate region; other site 445985001110 putative PBP binding loops; other site 445985001111 ABC-ATPase subunit interface; other site 445985001112 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 445985001113 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 445985001114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985001115 dimer interface [polypeptide binding]; other site 445985001116 conserved gate region; other site 445985001117 putative PBP binding loops; other site 445985001118 ABC-ATPase subunit interface; other site 445985001119 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 445985001120 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 445985001121 Walker A/P-loop; other site 445985001122 ATP binding site [chemical binding]; other site 445985001123 Q-loop/lid; other site 445985001124 ABC transporter signature motif; other site 445985001125 Walker B; other site 445985001126 D-loop; other site 445985001127 H-loop/switch region; other site 445985001128 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 445985001129 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 445985001130 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 445985001131 enolase; Provisional; Region: eno; PRK00077 445985001132 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 445985001133 dimer interface [polypeptide binding]; other site 445985001134 metal binding site [ion binding]; metal-binding site 445985001135 substrate binding pocket [chemical binding]; other site 445985001136 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 445985001137 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 445985001138 23S rRNA interface [nucleotide binding]; other site 445985001139 L3 interface [polypeptide binding]; other site 445985001140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 445985001141 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 445985001142 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 445985001143 GatB domain; Region: GatB_Yqey; pfam02637 445985001144 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 445985001145 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 445985001146 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 445985001147 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 445985001148 Part of AAA domain; Region: AAA_19; pfam13245 445985001149 Family description; Region: UvrD_C_2; pfam13538 445985001150 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 445985001151 Helix-turn-helix domain; Region: HTH_25; pfam13413 445985001152 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 445985001153 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 445985001154 Domain of unknown function (DUF814); Region: DUF814; pfam05670 445985001155 pyruvate kinase; Region: pyruv_kin; TIGR01064 445985001156 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 445985001157 domain interfaces; other site 445985001158 active site 445985001159 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 445985001160 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 445985001161 RNA methyltransferase, RsmE family; Region: TIGR00046 445985001162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 445985001163 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 445985001164 C-terminal peptidase (prc); Region: prc; TIGR00225 445985001165 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 445985001166 protein binding site [polypeptide binding]; other site 445985001167 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 445985001168 Catalytic dyad [active] 445985001169 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 445985001170 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 445985001171 P-loop; other site 445985001172 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 445985001173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 445985001174 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 445985001175 active site 445985001176 dimer interfaces [polypeptide binding]; other site 445985001177 catalytic residues [active] 445985001178 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 445985001179 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 445985001180 oligomer interface [polypeptide binding]; other site 445985001181 putative active site [active] 445985001182 metal binding site [ion binding]; metal-binding site 445985001183 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 445985001184 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 445985001185 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 445985001186 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 445985001187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985001188 Walker A motif; other site 445985001189 ATP binding site [chemical binding]; other site 445985001190 Walker B motif; other site 445985001191 arginine finger; other site 445985001192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 445985001193 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 445985001194 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 445985001195 active site 445985001196 HIGH motif; other site 445985001197 dimer interface [polypeptide binding]; other site 445985001198 KMSKS motif; other site 445985001199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445985001200 RNA binding surface [nucleotide binding]; other site 445985001201 glycyl-tRNA synthetase; Provisional; Region: PRK04173 445985001202 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 445985001203 dimer interface [polypeptide binding]; other site 445985001204 motif 1; other site 445985001205 active site 445985001206 motif 2; other site 445985001207 motif 3; other site 445985001208 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 445985001209 anticodon binding site; other site 445985001210 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 445985001211 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 445985001212 active site 445985001213 HIGH motif; other site 445985001214 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 445985001215 active site 445985001216 KMSKS motif; other site 445985001217 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 445985001218 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 445985001219 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 445985001220 S-adenosylmethionine synthetase; Region: metK; TIGR01034 445985001221 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 445985001222 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 445985001223 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 445985001224 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 445985001225 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 445985001226 HIT family signature motif; other site 445985001227 catalytic residue [active] 445985001228 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 445985001229 MgtE intracellular N domain; Region: MgtE_N; pfam03448 445985001230 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 445985001231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 445985001232 Divalent cation transporter; Region: MgtE; pfam01769 445985001233 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 445985001234 Trehalase; Region: Trehalase; cl17346 445985001235 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001236 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001237 ligand binding site [chemical binding]; other site 445985001238 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001239 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001240 ligand binding site [chemical binding]; other site 445985001241 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001242 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001243 ligand binding site [chemical binding]; other site 445985001244 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 445985001245 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 445985001246 ligand binding site [chemical binding]; other site 445985001247 30S ribosomal protein S7; Validated; Region: PRK05302 445985001248 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 445985001249 S17 interaction site [polypeptide binding]; other site 445985001250 S8 interaction site; other site 445985001251 16S rRNA interaction site [nucleotide binding]; other site 445985001252 streptomycin interaction site [chemical binding]; other site 445985001253 23S rRNA interaction site [nucleotide binding]; other site 445985001254 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 445985001255 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 445985001256 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 445985001257 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 445985001258 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 445985001259 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 445985001260 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 445985001261 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 445985001262 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 445985001263 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 445985001264 cleft; other site 445985001265 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 445985001266 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 445985001267 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 445985001268 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 445985001269 DNA binding site [nucleotide binding] 445985001270 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 445985001271 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 445985001272 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 445985001273 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 445985001274 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 445985001275 RPB10 interaction site [polypeptide binding]; other site 445985001276 RPB1 interaction site [polypeptide binding]; other site 445985001277 RPB11 interaction site [polypeptide binding]; other site 445985001278 RPB3 interaction site [polypeptide binding]; other site 445985001279 RPB12 interaction site [polypeptide binding]; other site 445985001280 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 445985001281 core dimer interface [polypeptide binding]; other site 445985001282 peripheral dimer interface [polypeptide binding]; other site 445985001283 L10 interface [polypeptide binding]; other site 445985001284 L11 interface [polypeptide binding]; other site 445985001285 putative EF-Tu interaction site [polypeptide binding]; other site 445985001286 putative EF-G interaction site [polypeptide binding]; other site 445985001287 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 445985001288 23S rRNA interface [nucleotide binding]; other site 445985001289 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 445985001290 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 445985001291 mRNA/rRNA interface [nucleotide binding]; other site 445985001292 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 445985001293 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 445985001294 23S rRNA interface [nucleotide binding]; other site 445985001295 L7/L12 interface [polypeptide binding]; other site 445985001296 putative thiostrepton binding site; other site 445985001297 L25 interface [polypeptide binding]; other site 445985001298 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 445985001299 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 445985001300 putative homodimer interface [polypeptide binding]; other site 445985001301 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 445985001302 heterodimer interface [polypeptide binding]; other site 445985001303 homodimer interface [polypeptide binding]; other site 445985001304 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 445985001305 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445985001306 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445985001307 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 445985001308 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 445985001309 prolyl-tRNA synthetase; Provisional; Region: PRK08661 445985001310 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 445985001311 dimer interface [polypeptide binding]; other site 445985001312 motif 1; other site 445985001313 active site 445985001314 motif 2; other site 445985001315 motif 3; other site 445985001316 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 445985001317 anticodon binding site; other site 445985001318 zinc-binding site [ion binding]; other site 445985001319 Predicted secreted protein [Function unknown]; Region: COG5497 445985001320 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 445985001321 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 445985001322 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 445985001323 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 445985001324 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 445985001325 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 445985001326 active site 445985001327 phosphorylation site [posttranslational modification] 445985001328 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 445985001329 active site 445985001330 P-loop; other site 445985001331 phosphorylation site [posttranslational modification] 445985001332 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 445985001333 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 445985001334 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 445985001335 active site 445985001336 substrate binding site [chemical binding]; other site 445985001337 Mg2+ binding site [ion binding]; other site 445985001338 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 445985001339 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 445985001340 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 445985001341 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 445985001342 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 445985001343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 445985001344 active site 445985001345 phosphorylation site [posttranslational modification] 445985001346 intermolecular recognition site; other site 445985001347 CheB methylesterase; Region: CheB_methylest; pfam01339 445985001348 pheromone shutdown-related protein TraB; Region: traB; TIGR00261 445985001349 adenylate kinase; Provisional; Region: PRK14526 445985001350 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 445985001351 AMP-binding site [chemical binding]; other site 445985001352 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 445985001353 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445985001355 active site 445985001356 phosphorylation site [posttranslational modification] 445985001357 intermolecular recognition site; other site 445985001358 dimerization interface [polypeptide binding]; other site 445985001359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 445985001360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 445985001361 metal binding site [ion binding]; metal-binding site 445985001362 active site 445985001363 I-site; other site 445985001364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 445985001365 substrate binding pocket [chemical binding]; other site 445985001366 membrane-bound complex binding site; other site 445985001367 hinge residues; other site 445985001368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 445985001369 dimer interface [polypeptide binding]; other site 445985001370 phosphorylation site [posttranslational modification] 445985001371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001372 ATP binding site [chemical binding]; other site 445985001373 Mg2+ binding site [ion binding]; other site 445985001374 G-X-G motif; other site 445985001375 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445985001377 active site 445985001378 phosphorylation site [posttranslational modification] 445985001379 intermolecular recognition site; other site 445985001380 dimerization interface [polypeptide binding]; other site 445985001381 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 445985001382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445985001383 active site 445985001384 motif I; other site 445985001385 motif II; other site 445985001386 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 445985001387 active site 445985001388 DNA binding site [nucleotide binding] 445985001389 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 445985001390 Predicted methyltransferases [General function prediction only]; Region: COG0313 445985001391 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 445985001392 putative SAM binding site [chemical binding]; other site 445985001393 putative homodimer interface [polypeptide binding]; other site 445985001394 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 445985001395 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 445985001396 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 445985001397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985001398 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985001399 P-loop; other site 445985001400 Magnesium ion binding site [ion binding]; other site 445985001401 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985001402 Magnesium ion binding site [ion binding]; other site 445985001403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445985001404 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 445985001405 ParB-like nuclease domain; Region: ParB; smart00470 445985001406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 445985001407 DNA gyrase, A subunit; Region: gyrA; TIGR01063 445985001408 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 445985001409 CAP-like domain; other site 445985001410 active site 445985001411 primary dimer interface [polypeptide binding]; other site 445985001412 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001413 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001414 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445985001416 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 445985001417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001418 ATP binding site [chemical binding]; other site 445985001419 Mg2+ binding site [ion binding]; other site 445985001420 G-X-G motif; other site 445985001421 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 445985001422 anchoring element; other site 445985001423 dimer interface [polypeptide binding]; other site 445985001424 ATP binding site [chemical binding]; other site 445985001425 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 445985001426 active site 445985001427 putative metal-binding site [ion binding]; other site 445985001428 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 445985001429 DnaA N-terminal domain; Region: DnaA_N; pfam11638 445985001430 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 445985001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985001432 Walker A motif; other site 445985001433 ATP binding site [chemical binding]; other site 445985001434 Walker B motif; other site 445985001435 arginine finger; other site 445985001436 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 445985001437 DnaA box-binding interface [nucleotide binding]; other site 445985001438 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 445985001439 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 445985001440 putative DNA binding surface [nucleotide binding]; other site 445985001441 dimer interface [polypeptide binding]; other site 445985001442 beta-clamp/clamp loader binding surface; other site 445985001443 beta-clamp/translesion DNA polymerase binding surface; other site 445985001444 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 445985001445 Ribonuclease P; Region: Ribonuclease_P; cl00457 445985001446 membrane protein insertase; Provisional; Region: PRK01318 445985001447 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 445985001448 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 445985001449 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 445985001450 G-X-X-G motif; other site 445985001451 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 445985001452 RxxxH motif; other site 445985001453 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 445985001454 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 445985001455 putative NAD(P) binding site [chemical binding]; other site 445985001456 active site 445985001457 putative substrate binding site [chemical binding]; other site 445985001458 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 445985001459 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 445985001460 active site 445985001461 intersubunit interface [polypeptide binding]; other site 445985001462 zinc binding site [ion binding]; other site 445985001463 Na+ binding site [ion binding]; other site 445985001464 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 445985001465 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 445985001466 dimer interface [polypeptide binding]; other site 445985001467 anticodon binding site; other site 445985001468 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 445985001469 homodimer interface [polypeptide binding]; other site 445985001470 motif 1; other site 445985001471 active site 445985001472 motif 2; other site 445985001473 GAD domain; Region: GAD; pfam02938 445985001474 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 445985001475 active site 445985001476 motif 3; other site 445985001477 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 445985001478 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 445985001479 Sexual stage antigen s48/45 domain; Region: s48_45; smart00970 445985001480 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 445985001481 active site 445985001482 phosphorylation site [posttranslational modification] 445985001483 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 445985001484 dimerization domain swap beta strand [polypeptide binding]; other site 445985001485 regulatory protein interface [polypeptide binding]; other site 445985001486 active site 445985001487 regulatory phosphorylation site [posttranslational modification]; other site 445985001488 Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis]; Region: COG1544 445985001489 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 445985001490 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 445985001491 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 445985001492 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 445985001493 Chromate transporter; Region: Chromate_transp; cl17781 445985001494 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 445985001495 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 445985001496 Mechanosensitive ion channel; Region: MS_channel; pfam00924 445985001497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 445985001498 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 445985001499 putative ADP-binding pocket [chemical binding]; other site 445985001500 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 445985001501 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 445985001502 GIY-YIG motif/motif A; other site 445985001503 active site 445985001504 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 445985001505 catalytic site [active] 445985001506 putative DNA binding site [nucleotide binding]; other site 445985001507 metal binding site [ion binding]; metal-binding site 445985001508 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 445985001509 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 445985001510 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 445985001511 Interdomain contacts; other site 445985001512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001513 binding surface 445985001514 TPR repeat; Region: TPR_11; pfam13414 445985001515 TPR motif; other site 445985001516 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 445985001517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985001518 Walker A motif; other site 445985001519 ATP binding site [chemical binding]; other site 445985001520 Walker B motif; other site 445985001521 DNA polymerase III subunit delta'; Validated; Region: PRK08485 445985001522 arginine finger; other site 445985001523 hypothetical protein; Provisional; Region: PRK14629 445985001524 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 445985001525 active site 445985001526 multimer interface [polypeptide binding]; other site 445985001527 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 445985001528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 445985001529 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 445985001530 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 445985001531 Walker A/P-loop; other site 445985001532 ATP binding site [chemical binding]; other site 445985001533 Q-loop/lid; other site 445985001534 ABC transporter signature motif; other site 445985001535 Walker B; other site 445985001536 D-loop; other site 445985001537 H-loop/switch region; other site 445985001538 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 445985001539 uncharacterized protein, YfiH family; Region: TIGR00726 445985001540 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 445985001541 Uncharacterized conserved protein [Function unknown]; Region: COG0327 445985001542 signal peptidase II; Provisional; Region: lspA; PRK01574 445985001543 lipoprotein signal peptidase; Provisional; Region: PRK14787 445985001544 Calcineurin-like phosphoesterase [General function prediction only]; Region: COG1692 445985001545 active site 445985001546 metal binding site [ion binding]; metal-binding site 445985001547 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 445985001548 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 445985001549 hinge; other site 445985001550 active site 445985001551 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 445985001552 putative efflux protein, MATE family; Region: matE; TIGR00797 445985001553 elongation factor Tu; Reviewed; Region: PRK00049 445985001554 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 445985001555 G1 box; other site 445985001556 GEF interaction site [polypeptide binding]; other site 445985001557 GTP/Mg2+ binding site [chemical binding]; other site 445985001558 Switch I region; other site 445985001559 G2 box; other site 445985001560 G3 box; other site 445985001561 Switch II region; other site 445985001562 G4 box; other site 445985001563 G5 box; other site 445985001564 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 445985001565 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 445985001566 Antibiotic Binding Site [chemical binding]; other site 445985001567 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 445985001568 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 445985001569 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 445985001570 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 445985001571 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 445985001572 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 445985001573 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 445985001574 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 445985001575 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 445985001576 putative translocon binding site; other site 445985001577 protein-rRNA interface [nucleotide binding]; other site 445985001578 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 445985001579 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 445985001580 G-X-X-G motif; other site 445985001581 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 445985001582 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 445985001583 23S rRNA interface [nucleotide binding]; other site 445985001584 5S rRNA interface [nucleotide binding]; other site 445985001585 putative antibiotic binding site [chemical binding]; other site 445985001586 L25 interface [polypeptide binding]; other site 445985001587 L27 interface [polypeptide binding]; other site 445985001588 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 445985001589 23S rRNA interface [nucleotide binding]; other site 445985001590 putative translocon interaction site; other site 445985001591 signal recognition particle (SRP54) interaction site; other site 445985001592 L23 interface [polypeptide binding]; other site 445985001593 trigger factor interaction site; other site 445985001594 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 445985001595 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 445985001596 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 445985001597 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 445985001598 RNA binding site [nucleotide binding]; other site 445985001599 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 445985001600 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 445985001601 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 445985001602 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 445985001603 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 445985001604 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 445985001605 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 445985001606 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 445985001607 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 445985001608 5S rRNA interface [nucleotide binding]; other site 445985001609 23S rRNA interface [nucleotide binding]; other site 445985001610 L5 interface [polypeptide binding]; other site 445985001611 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 445985001612 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 445985001613 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 445985001614 ribosomal protein L30, bacterial/organelle; Region: rpmD_bact; TIGR01308 445985001615 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 445985001616 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 445985001617 SecY translocase; Region: SecY; pfam00344 445985001618 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 445985001619 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 445985001620 30S ribosomal protein S13; Region: bact_S13; TIGR03631 445985001621 30S ribosomal protein S11; Validated; Region: PRK05309 445985001622 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 445985001623 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 445985001624 alphaNTD - beta interaction site [polypeptide binding]; other site 445985001625 alphaNTD homodimer interface [polypeptide binding]; other site 445985001626 alphaNTD - beta' interaction site [polypeptide binding]; other site 445985001627 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 445985001628 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 445985001629 phosphodiesterase; Provisional; Region: PRK12704 445985001630 KH domain; Region: KH_1; pfam00013 445985001631 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445985001632 Zn2+ binding site [ion binding]; other site 445985001633 Mg2+ binding site [ion binding]; other site 445985001634 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 445985001635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 445985001636 putative active site [active] 445985001637 metal binding site [ion binding]; metal-binding site 445985001638 homodimer binding site [polypeptide binding]; other site 445985001639 hemolysin TlyA family protein; Region: tly; TIGR00478 445985001640 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 445985001641 Spore germination protein [General function prediction only]; Region: COG5401 445985001642 Sporulation and spore germination; Region: Germane; smart00909 445985001643 GTP-binding protein Der; Reviewed; Region: PRK00093 445985001644 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 445985001645 G1 box; other site 445985001646 GTP/Mg2+ binding site [chemical binding]; other site 445985001647 Switch I region; other site 445985001648 G2 box; other site 445985001649 Switch II region; other site 445985001650 G3 box; other site 445985001651 G4 box; other site 445985001652 G5 box; other site 445985001653 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 445985001654 G1 box; other site 445985001655 GTP/Mg2+ binding site [chemical binding]; other site 445985001656 Switch I region; other site 445985001657 G2 box; other site 445985001658 G3 box; other site 445985001659 Switch II region; other site 445985001660 G4 box; other site 445985001661 G5 box; other site 445985001662 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 445985001663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445985001664 motif II; other site 445985001665 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 445985001666 AAA domain; Region: AAA_13; pfam13166 445985001667 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445985001668 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 445985001669 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 445985001670 dimer interface [polypeptide binding]; other site 445985001671 motif 1; other site 445985001672 active site 445985001673 motif 2; other site 445985001674 motif 3; other site 445985001675 phenylalanyl-tRNA synthetase, beta subunit; Region: pheT_arch; TIGR00471 445985001676 tRNA synthetase B5 domain; Region: B5; pfam03484 445985001677 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 445985001678 motif 1; other site 445985001679 dimer interface [polypeptide binding]; other site 445985001680 active site 445985001681 motif 2; other site 445985001682 motif 3; other site 445985001683 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 445985001684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 445985001685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 445985001686 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 445985001687 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 445985001688 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 445985001689 chaperone protein DnaJ; Provisional; Region: PRK14285 445985001690 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 445985001691 HSP70 interaction site [polypeptide binding]; other site 445985001692 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 445985001693 Zn binding sites [ion binding]; other site 445985001694 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 445985001695 dimer interface [polypeptide binding]; other site 445985001696 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 445985001697 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 445985001698 nucleotide binding site [chemical binding]; other site 445985001699 NEF interaction site [polypeptide binding]; other site 445985001700 SBD interface [polypeptide binding]; other site 445985001701 GrpE; Region: GrpE; pfam01025 445985001702 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 445985001703 dimer interface [polypeptide binding]; other site 445985001704 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 445985001705 NAD synthetase; Provisional; Region: PRK13981 445985001706 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 445985001707 active site 445985001708 catalytic triad [active] 445985001709 dimer interface [polypeptide binding]; other site 445985001710 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 445985001711 homodimer interface [polypeptide binding]; other site 445985001712 NAD binding pocket [chemical binding]; other site 445985001713 ATP binding pocket [chemical binding]; other site 445985001714 Mg binding site [ion binding]; other site 445985001715 active-site loop [active] 445985001716 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 445985001717 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 445985001718 active site 445985001719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 445985001720 nucleotide binding site [chemical binding]; other site 445985001721 Type III pantothenate kinase; Region: Pan_kinase; cl17198 445985001722 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 445985001723 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 445985001724 active site 445985001725 catalytic tetrad [active] 445985001726 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 445985001727 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 445985001728 putative hydrolase; Provisional; Region: PRK02113 445985001729 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 445985001730 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 445985001731 active site 445985001732 putative catalytic site [active] 445985001733 phosphate binding site A [ion binding]; other site 445985001734 DNA binding site [nucleotide binding] 445985001735 metal binding site A [ion binding]; metal-binding site 445985001736 putative AP binding site [nucleotide binding]; other site 445985001737 putative metal binding site B [ion binding]; other site 445985001738 phosphate binding site B [ion binding]; other site 445985001739 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 445985001740 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 445985001741 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985001742 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 445985001743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001744 binding surface 445985001745 TPR motif; other site 445985001746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001747 binding surface 445985001748 TPR repeat; Region: TPR_11; pfam13414 445985001749 TPR motif; other site 445985001750 TPR repeat; Region: TPR_11; pfam13414 445985001751 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 445985001752 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 445985001753 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 445985001754 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 445985001755 translation elongation factor EF-G; Region: EF-G; TIGR00484 445985001756 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 445985001757 G1 box; other site 445985001758 putative GEF interaction site [polypeptide binding]; other site 445985001759 GTP/Mg2+ binding site [chemical binding]; other site 445985001760 Switch I region; other site 445985001761 G2 box; other site 445985001762 G3 box; other site 445985001763 Switch II region; other site 445985001764 G4 box; other site 445985001765 G5 box; other site 445985001766 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 445985001767 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 445985001768 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 445985001769 KTSC domain; Region: KTSC; pfam13619 445985001770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445985001771 binding surface 445985001772 TPR motif; other site 445985001773 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 445985001774 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 445985001775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445985001776 active site 445985001777 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 445985001778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 445985001779 nucleotide binding site [chemical binding]; other site 445985001780 cell division protein FtsN; Region: ftsN; TIGR02223 445985001781 Sporulation related domain; Region: SPOR; pfam05036 445985001782 dephospho-CoA kinase; Region: TIGR00152 445985001783 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 445985001784 CoA-binding site [chemical binding]; other site 445985001785 ATP-binding [chemical binding]; other site 445985001786 DNA polymerase I; Region: pola; TIGR00593 445985001787 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 445985001788 active site 445985001789 metal binding site 1 [ion binding]; metal-binding site 445985001790 putative 5' ssDNA interaction site; other site 445985001791 metal binding site 3; metal-binding site 445985001792 metal binding site 2 [ion binding]; metal-binding site 445985001793 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 445985001794 putative DNA binding site [nucleotide binding]; other site 445985001795 putative metal binding site [ion binding]; other site 445985001796 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 445985001797 active site 445985001798 catalytic site [active] 445985001799 substrate binding site [chemical binding]; other site 445985001800 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 445985001801 active site 445985001802 DNA binding site [nucleotide binding] 445985001803 catalytic site [active] 445985001804 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 445985001805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445985001806 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001807 active site 445985001808 phosphorylation site [posttranslational modification] 445985001809 intermolecular recognition site; other site 445985001810 dimerization interface [polypeptide binding]; other site 445985001811 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 445985001812 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 445985001813 nucleotide binding pocket [chemical binding]; other site 445985001814 K-X-D-G motif; other site 445985001815 catalytic site [active] 445985001816 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 445985001817 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 445985001818 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 445985001819 Dimer interface [polypeptide binding]; other site 445985001820 BRCT sequence motif; other site 445985001821 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445985001822 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 445985001823 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 445985001824 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 445985001825 dimerization domain swap beta strand [polypeptide binding]; other site 445985001826 regulatory protein interface [polypeptide binding]; other site 445985001827 active site 445985001828 regulatory phosphorylation site [posttranslational modification]; other site 445985001829 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 445985001830 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 445985001831 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 445985001832 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 445985001833 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 445985001834 HPr interaction site; other site 445985001835 glycerol kinase (GK) interaction site [polypeptide binding]; other site 445985001836 active site 445985001837 phosphorylation site [posttranslational modification] 445985001838 heat shock protein 90; Provisional; Region: PRK05218 445985001839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001840 ATP binding site [chemical binding]; other site 445985001841 Mg2+ binding site [ion binding]; other site 445985001842 G-X-G motif; other site 445985001843 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 445985001844 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 445985001845 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 445985001846 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 445985001847 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 445985001848 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 445985001849 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 445985001850 putative CheA interaction surface; other site 445985001851 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 445985001852 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 445985001853 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 445985001854 putative binding surface; other site 445985001855 active site 445985001856 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 445985001857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985001858 ATP binding site [chemical binding]; other site 445985001859 Mg2+ binding site [ion binding]; other site 445985001860 G-X-G motif; other site 445985001861 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 445985001862 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 445985001863 CheB methylesterase; Region: CheB_methylest; pfam01339 445985001864 chromosome segregation protein; Provisional; Region: PRK01156 445985001865 Response regulator receiver domain; Region: Response_reg; pfam00072 445985001866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445985001867 active site 445985001868 phosphorylation site [posttranslational modification] 445985001869 intermolecular recognition site; other site 445985001870 dimerization interface [polypeptide binding]; other site 445985001871 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 445985001872 nucleotide binding site [chemical binding]; other site 445985001873 homodimeric interface [polypeptide binding]; other site 445985001874 uridine monophosphate binding site [chemical binding]; other site 445985001875 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 445985001876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 445985001877 active site 445985001878 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 445985001879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985001880 Walker A/P-loop; other site 445985001881 ATP binding site [chemical binding]; other site 445985001882 Q-loop/lid; other site 445985001883 ABC transporter signature motif; other site 445985001884 Walker B; other site 445985001885 D-loop; other site 445985001886 H-loop/switch region; other site 445985001887 CTP synthase; Region: PyrG; TIGR00337 445985001888 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 445985001889 Catalytic site [active] 445985001890 active site 445985001891 UTP binding site [chemical binding]; other site 445985001892 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 445985001893 active site 445985001894 putative oxyanion hole; other site 445985001895 catalytic triad [active] 445985001896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 445985001897 putative CheW interface [polypeptide binding]; other site 445985001898 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 445985001899 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 445985001900 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 445985001901 active site 445985001902 PHP Thumb interface [polypeptide binding]; other site 445985001903 metal binding site [ion binding]; metal-binding site 445985001904 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 445985001905 generic binding surface I; other site 445985001906 generic binding surface II; other site 445985001907 YGGT family; Region: YGGT; pfam02325 445985001908 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 445985001909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985001910 ATP binding site [chemical binding]; other site 445985001911 putative Mg++ binding site [ion binding]; other site 445985001912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985001913 nucleotide binding region [chemical binding]; other site 445985001914 ATP-binding site [chemical binding]; other site 445985001915 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 445985001916 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 445985001917 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 445985001918 putative efflux protein, MATE family; Region: matE; TIGR00797 445985001919 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 445985001920 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 445985001921 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 445985001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445985001923 NAD(P) binding site [chemical binding]; other site 445985001924 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985001925 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985001926 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 445985001927 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 445985001928 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 445985001929 active site 445985001930 HIGH motif; other site 445985001931 KMSKS motif; other site 445985001932 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 445985001933 tRNA binding surface [nucleotide binding]; other site 445985001934 anticodon binding site; other site 445985001935 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 445985001936 putative tRNA-binding site [nucleotide binding]; other site 445985001937 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 445985001938 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 445985001939 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 445985001940 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 445985001941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445985001942 S-adenosylmethionine binding site [chemical binding]; other site 445985001943 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 445985001944 CAAX protease self-immunity; Region: Abi; pfam02517 445985001945 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 445985001946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 445985001947 acyl-activating enzyme (AAE) consensus motif; other site 445985001948 AMP binding site [chemical binding]; other site 445985001949 active site 445985001950 CoA binding site [chemical binding]; other site 445985001951 arginyl-tRNA synthetase; Region: argS; TIGR00456 445985001952 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 445985001953 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 445985001954 active site 445985001955 HIGH motif; other site 445985001956 KMSK motif region; other site 445985001957 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 445985001958 tRNA binding surface [nucleotide binding]; other site 445985001959 anticodon binding site; other site 445985001960 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 445985001961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 445985001962 putative CheW interface [polypeptide binding]; other site 445985001963 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 445985001964 FAD binding domain; Region: FAD_binding_4; pfam01565 445985001965 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 445985001966 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14534 445985001967 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985001968 active site 445985001969 HIGH motif; other site 445985001970 nucleotide binding site [chemical binding]; other site 445985001971 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 445985001972 KMSKS motif; other site 445985001973 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 445985001974 tRNA binding surface [nucleotide binding]; other site 445985001975 anticodon binding site; other site 445985001976 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 445985001977 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 445985001978 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 445985001979 dimer interface [polypeptide binding]; other site 445985001980 active site 445985001981 glycine-pyridoxal phosphate binding site [chemical binding]; other site 445985001982 folate binding site [chemical binding]; other site 445985001983 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 445985001984 HSP70 interaction site [polypeptide binding]; other site 445985001985 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 445985001986 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 445985001987 L-lactate permease; Region: Lactate_perm; pfam02652 445985001988 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 445985001989 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 445985001990 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 445985001991 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13494 445985001992 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 445985001993 Part of AAA domain; Region: AAA_19; pfam13245 445985001994 Family description; Region: UvrD_C_2; pfam13538 445985001995 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 445985001996 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 445985001997 metal binding site [ion binding]; metal-binding site 445985001998 dimer interface [polypeptide binding]; other site 445985001999 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 445985002000 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 445985002001 oligomer interface [polypeptide binding]; other site 445985002002 active site residues [active] 445985002003 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 445985002004 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 445985002005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985002006 Walker A motif; other site 445985002007 ATP binding site [chemical binding]; other site 445985002008 Walker B motif; other site 445985002009 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 445985002010 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 445985002011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985002012 Walker A motif; other site 445985002013 ATP binding site [chemical binding]; other site 445985002014 Walker B motif; other site 445985002015 arginine finger; other site 445985002016 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 445985002017 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 445985002018 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 445985002019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445985002020 RNA binding surface [nucleotide binding]; other site 445985002021 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 445985002022 Cation efflux family; Region: Cation_efflux; pfam01545 445985002023 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 445985002024 DHH family; Region: DHH; pfam01368 445985002025 DHHA1 domain; Region: DHHA1; pfam02272 445985002026 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 445985002027 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 445985002028 DJ-1 family protein; Region: not_thiJ; TIGR01383 445985002029 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 445985002030 conserved cys residue [active] 445985002031 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 445985002032 propionate/acetate kinase; Provisional; Region: PRK12379 445985002033 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 445985002034 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 445985002035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985002036 ATP binding site [chemical binding]; other site 445985002037 putative Mg++ binding site [ion binding]; other site 445985002038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985002039 nucleotide binding region [chemical binding]; other site 445985002040 ATP-binding site [chemical binding]; other site 445985002041 TRCF domain; Region: TRCF; pfam03461 445985002042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985002043 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 445985002044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985002045 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985002046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985002047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985002048 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 445985002049 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 445985002050 active site 445985002051 metal binding site [ion binding]; metal-binding site 445985002052 M18 Peptidase aminopeptidase family; Region: M18; cd05639 445985002053 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 445985002054 active site 445985002055 metal binding site [ion binding]; metal-binding site 445985002056 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 445985002057 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 445985002058 active site 445985002059 phosphorylation site [posttranslational modification] 445985002060 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 445985002061 active site 445985002062 P-loop; other site 445985002063 phosphorylation site [posttranslational modification] 445985002064 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 445985002065 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 445985002066 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 445985002067 putative substrate binding site [chemical binding]; other site 445985002068 putative ATP binding site [chemical binding]; other site 445985002069 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 445985002070 AAA domain; Region: AAA_30; pfam13604 445985002071 Family description; Region: UvrD_C_2; pfam13538 445985002072 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 445985002073 Part of AAA domain; Region: AAA_19; pfam13245 445985002074 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 445985002075 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 445985002076 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 445985002077 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 445985002078 active site 445985002079 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 445985002080 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 445985002081 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 445985002082 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 445985002083 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 445985002084 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 445985002085 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 445985002086 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 445985002087 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 445985002088 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 445985002089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985002090 dimer interface [polypeptide binding]; other site 445985002091 conserved gate region; other site 445985002092 putative PBP binding loops; other site 445985002093 ABC-ATPase subunit interface; other site 445985002094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985002095 dimer interface [polypeptide binding]; other site 445985002096 conserved gate region; other site 445985002097 putative PBP binding loops; other site 445985002098 ABC-ATPase subunit interface; other site 445985002099 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 445985002100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985002101 Walker A/P-loop; other site 445985002102 ATP binding site [chemical binding]; other site 445985002103 Q-loop/lid; other site 445985002104 ABC transporter signature motif; other site 445985002105 Walker B; other site 445985002106 D-loop; other site 445985002107 H-loop/switch region; other site 445985002108 TOBE domain; Region: TOBE_2; pfam08402 445985002109 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 445985002110 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 445985002111 GTP/Mg2+ binding site [chemical binding]; other site 445985002112 G4 box; other site 445985002113 G5 box; other site 445985002114 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 445985002115 G1 box; other site 445985002116 G1 box; other site 445985002117 GTP/Mg2+ binding site [chemical binding]; other site 445985002118 Switch I region; other site 445985002119 G2 box; other site 445985002120 G2 box; other site 445985002121 G3 box; other site 445985002122 G3 box; other site 445985002123 Switch II region; other site 445985002124 Switch II region; other site 445985002125 G4 box; other site 445985002126 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 445985002127 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 445985002128 putative active site cavity [active] 445985002129 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 445985002130 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 445985002131 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 445985002132 active site turn [active] 445985002133 phosphorylation site [posttranslational modification] 445985002134 Esterase/lipase [General function prediction only]; Region: COG1647 445985002135 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 445985002136 metal binding site 2 [ion binding]; metal-binding site 445985002137 putative DNA binding helix; other site 445985002138 metal binding site 1 [ion binding]; metal-binding site 445985002139 structural Zn2+ binding site [ion binding]; other site 445985002140 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 445985002141 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 445985002142 ring oligomerisation interface [polypeptide binding]; other site 445985002143 ATP/Mg binding site [chemical binding]; other site 445985002144 stacking interactions; other site 445985002145 hinge regions; other site 445985002146 protein-export membrane protein SecD; Region: secD; TIGR01129 445985002147 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 445985002148 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 445985002149 Protein export membrane protein; Region: SecD_SecF; pfam02355 445985002150 chaperone protein DnaJ; Provisional; Region: PRK14299 445985002151 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 445985002152 HSP70 interaction site [polypeptide binding]; other site 445985002153 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 445985002154 substrate binding site [polypeptide binding]; other site 445985002155 dimer interface [polypeptide binding]; other site 445985002156 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 445985002157 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 445985002158 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445985002159 active site 445985002160 dimer interface [polypeptide binding]; other site 445985002161 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445985002162 catalytic core [active] 445985002163 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445985002164 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 445985002165 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 445985002166 active site 445985002167 HIGH motif; other site 445985002168 KMSKS motif; other site 445985002169 GTPase Era; Reviewed; Region: era; PRK00089 445985002170 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 445985002171 G1 box; other site 445985002172 GTP/Mg2+ binding site [chemical binding]; other site 445985002173 Switch I region; other site 445985002174 G2 box; other site 445985002175 Switch II region; other site 445985002176 G3 box; other site 445985002177 G4 box; other site 445985002178 G5 box; other site 445985002179 KH domain; Region: KH_2; pfam07650 445985002180 Double zinc ribbon; Region: DZR; pfam12773 445985002181 Uncharacterized conserved protein [Function unknown]; Region: COG1430 445985002182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 445985002183 active site 445985002184 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 445985002185 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 445985002186 active site 445985002187 metal binding site [ion binding]; metal-binding site 445985002188 Sporulation and spore germination; Region: Germane; pfam10646 445985002189 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 445985002190 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 445985002191 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 445985002192 putative binding surface; other site 445985002193 active site 445985002194 P2 response regulator binding domain; Region: P2; pfam07194 445985002195 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 445985002196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445985002197 ATP binding site [chemical binding]; other site 445985002198 G-X-G motif; other site 445985002199 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 445985002200 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 445985002201 putative CheA interaction surface; other site 445985002202 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 445985002203 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 445985002204 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 445985002205 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 445985002206 Response regulator receiver domain; Region: Response_reg; pfam00072 445985002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445985002208 active site 445985002209 phosphorylation site [posttranslational modification] 445985002210 intermolecular recognition site; other site 445985002211 dimerization interface [polypeptide binding]; other site 445985002212 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 445985002213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445985002214 motif II; other site 445985002215 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 445985002216 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 445985002217 Walker A/P-loop; other site 445985002218 ATP binding site [chemical binding]; other site 445985002219 Q-loop/lid; other site 445985002220 ABC transporter signature motif; other site 445985002221 Walker B; other site 445985002222 D-loop; other site 445985002223 H-loop/switch region; other site 445985002224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985002225 Walker A/P-loop; other site 445985002226 ATP binding site [chemical binding]; other site 445985002227 Q-loop/lid; other site 445985002228 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 445985002229 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 445985002230 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985002231 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985002232 TM-ABC transporter signature motif; other site 445985002233 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 445985002234 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 445985002235 TM-ABC transporter signature motif; other site 445985002236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 445985002237 dimer interface [polypeptide binding]; other site 445985002238 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 445985002239 putative CheW interface [polypeptide binding]; other site 445985002240 HAMP domain; Region: HAMP; pfam00672 445985002241 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 445985002242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 445985002243 dimer interface [polypeptide binding]; other site 445985002244 putative CheW interface [polypeptide binding]; other site 445985002245 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 445985002246 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 445985002247 Ligand Binding Site [chemical binding]; other site 445985002248 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 445985002249 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 445985002250 dimer interface [polypeptide binding]; other site 445985002251 active site 445985002252 isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151 445985002253 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 445985002254 homotetramer interface [polypeptide binding]; other site 445985002255 FMN binding site [chemical binding]; other site 445985002256 homodimer contacts [polypeptide binding]; other site 445985002257 putative active site [active] 445985002258 putative substrate binding site [chemical binding]; other site 445985002259 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 445985002260 homodimer interface [polypeptide binding]; other site 445985002261 catalytic residues [active] 445985002262 NAD binding site [chemical binding]; other site 445985002263 substrate binding pocket [chemical binding]; other site 445985002264 flexible flap; other site 445985002265 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 445985002266 diphosphomevalonate decarboxylase; Region: PLN02407 445985002267 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 445985002268 mevalonate kinase; Region: mevalon_kin; TIGR00549 445985002269 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 445985002270 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 445985002271 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 445985002272 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 445985002273 dimerization interface [polypeptide binding]; other site 445985002274 DPS ferroxidase diiron center [ion binding]; other site 445985002275 ion pore; other site 445985002276 elongation factor G; Reviewed; Region: PRK13351 445985002277 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 445985002278 G1 box; other site 445985002279 putative GEF interaction site [polypeptide binding]; other site 445985002280 GTP/Mg2+ binding site [chemical binding]; other site 445985002281 Switch I region; other site 445985002282 G2 box; other site 445985002283 G3 box; other site 445985002284 Switch II region; other site 445985002285 G4 box; other site 445985002286 G5 box; other site 445985002287 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 445985002288 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 445985002289 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 445985002290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 445985002291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 445985002292 signal recognition particle protein; Provisional; Region: PRK10867 445985002293 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 445985002294 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 445985002295 P loop; other site 445985002296 GTP binding site [chemical binding]; other site 445985002297 Signal peptide binding domain; Region: SRP_SPB; pfam02978 445985002298 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 445985002299 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 445985002300 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 445985002301 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 445985002302 RimM N-terminal domain; Region: RimM; pfam01782 445985002303 tRNA (guanine-N1)-methyltransferase; Region: trmD; TIGR00088 445985002304 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 445985002305 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 445985002306 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985002307 active site 445985002308 nucleotide binding site [chemical binding]; other site 445985002309 HIGH motif; other site 445985002310 KMSKS motif; other site 445985002311 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 445985002312 acyl carrier protein; Region: acyl_carrier; TIGR00517 445985002313 ribonuclease III; Reviewed; Region: rnc; PRK00102 445985002314 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 445985002315 dimerization interface [polypeptide binding]; other site 445985002316 active site 445985002317 metal binding site [ion binding]; metal-binding site 445985002318 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 445985002319 dsRNA binding site [nucleotide binding]; other site 445985002320 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 445985002321 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 445985002322 active site 445985002323 NTP binding site [chemical binding]; other site 445985002324 metal binding triad [ion binding]; metal-binding site 445985002325 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 445985002326 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 445985002327 conserved hypothetical protein, YceG family; Region: TIGR00247 445985002328 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 445985002329 dimerization interface [polypeptide binding]; other site 445985002330 DNA primase, catalytic core; Region: dnaG; TIGR01391 445985002331 CHC2 zinc finger; Region: zf-CHC2; pfam01807 445985002332 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 445985002333 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 445985002334 active site 445985002335 metal binding site [ion binding]; metal-binding site 445985002336 interdomain interaction site; other site 445985002337 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 445985002338 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 445985002339 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 445985002340 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 445985002341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445985002342 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 445985002343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 445985002344 DNA binding residues [nucleotide binding] 445985002345 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 445985002346 Putative zinc ribbon domain; Region: DUF164; pfam02591 445985002347 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 445985002348 MreB and similar proteins; Region: MreB_like; cd10225 445985002349 nucleotide binding site [chemical binding]; other site 445985002350 Mg binding site [ion binding]; other site 445985002351 putative protofilament interaction site [polypeptide binding]; other site 445985002352 RodZ interaction site [polypeptide binding]; other site 445985002353 rod shape-determining protein MreC; Region: mreC; TIGR00219 445985002354 rod shape-determining protein MreC; Region: MreC; pfam04085 445985002355 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 445985002356 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 445985002357 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 445985002358 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 445985002359 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 445985002360 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 445985002361 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 445985002362 active site 445985002363 dimer interface [polypeptide binding]; other site 445985002364 motif 1; other site 445985002365 motif 2; other site 445985002366 motif 3; other site 445985002367 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 445985002368 anticodon binding site; other site 445985002369 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 445985002370 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 445985002371 putative active site [active] 445985002372 putative metal binding residues [ion binding]; other site 445985002373 signature motif; other site 445985002374 putative triphosphate binding site [ion binding]; other site 445985002375 dimer interface [polypeptide binding]; other site 445985002376 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 445985002377 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 445985002378 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 445985002379 TrkA-N domain; Region: TrkA_N; pfam02254 445985002380 TrkA-C domain; Region: TrkA_C; pfam02080 445985002381 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 445985002382 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 445985002383 P-loop; other site 445985002384 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 445985002385 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 445985002386 active site 445985002387 ADP/pyrophosphate binding site [chemical binding]; other site 445985002388 dimerization interface [polypeptide binding]; other site 445985002389 allosteric effector site; other site 445985002390 fructose-1,6-bisphosphate binding site; other site 445985002391 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 445985002392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 445985002393 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 445985002394 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 445985002395 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 445985002396 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 445985002397 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 445985002398 active site 445985002399 dimer interface [polypeptide binding]; other site 445985002400 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 445985002401 dimer interface [polypeptide binding]; other site 445985002402 active site 445985002403 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 445985002404 ParB-like nuclease domain; Region: ParB; smart00470 445985002405 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 445985002406 Transglycosylase; Region: Transgly; pfam00912 445985002407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 445985002408 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 445985002409 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 445985002410 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 445985002411 rare lipoprotein A; Region: rlpA; TIGR00413 445985002412 Sporulation related domain; Region: SPOR; pfam05036 445985002413 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 445985002414 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 445985002415 FMN binding site [chemical binding]; other site 445985002416 active site 445985002417 catalytic residues [active] 445985002418 substrate binding site [chemical binding]; other site 445985002419 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 445985002420 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445985002421 active site 445985002422 HIGH motif; other site 445985002423 nucleotide binding site [chemical binding]; other site 445985002424 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 445985002425 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 445985002426 active site 445985002427 KMSKS motif; other site 445985002428 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 445985002429 tRNA binding surface [nucleotide binding]; other site 445985002430 anticodon binding site; other site 445985002431 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 445985002432 Uncharacterized conserved protein [Function unknown]; Region: COG4121 445985002433 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 445985002434 oligomerisation interface [polypeptide binding]; other site 445985002435 mobile loop; other site 445985002436 roof hairpin; other site 445985002437 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 445985002438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985002439 Walker A/P-loop; other site 445985002440 ATP binding site [chemical binding]; other site 445985002441 Q-loop/lid; other site 445985002442 ABC transporter signature motif; other site 445985002443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 445985002444 Walker B; other site 445985002445 D-loop; other site 445985002446 H-loop/switch region; other site 445985002447 ABC transporter; Region: ABC_tran_2; pfam12848 445985002448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 445985002449 FOG: WD40-like repeat [Function unknown]; Region: COG1520 445985002450 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 445985002451 active site 445985002452 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 445985002453 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 445985002454 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 445985002455 minor groove reading motif; other site 445985002456 helix-hairpin-helix signature motif; other site 445985002457 substrate binding pocket [chemical binding]; other site 445985002458 active site 445985002459 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 445985002460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985002461 ABC-ATPase subunit interface; other site 445985002462 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 445985002463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445985002464 ABC-ATPase subunit interface; other site 445985002465 putative PBP binding loops; other site 445985002466 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 445985002467 Septum formation initiator; Region: DivIC; cl17659 445985002468 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 445985002469 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 445985002470 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 445985002471 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 445985002472 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 445985002473 Walker A/P-loop; other site 445985002474 ATP binding site [chemical binding]; other site 445985002475 Q-loop/lid; other site 445985002476 ABC transporter signature motif; other site 445985002477 Walker B; other site 445985002478 D-loop; other site 445985002479 H-loop/switch region; other site 445985002480 ribonuclease Z; Region: RNase_Z; TIGR02651 445985002481 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 445985002482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 445985002483 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 445985002484 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 445985002485 oligomer interface [polypeptide binding]; other site 445985002486 active site residues [active] 445985002487 Predicted membrane protein [Function unknown]; Region: COG2035 445985002488 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 445985002489 putative metal binding site [ion binding]; other site 445985002490 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 445985002491 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445985002492 Peptidase family M23; Region: Peptidase_M23; pfam01551 445985002493 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 445985002494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445985002495 active site 445985002496 phosphorylation site [posttranslational modification] 445985002497 intermolecular recognition site; other site 445985002498 dimerization interface [polypeptide binding]; other site 445985002499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985002500 Walker A motif; other site 445985002501 ATP binding site [chemical binding]; other site 445985002502 Walker B motif; other site 445985002503 arginine finger; other site 445985002504 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 445985002505 DNA polymerase III subunit delta'; Validated; Region: PRK08485 445985002506 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 445985002507 Colicin V production protein; Region: Colicin_V; pfam02674 445985002508 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 445985002509 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 445985002510 homodimer interface [polypeptide binding]; other site 445985002511 active site 445985002512 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 445985002513 dimer interface [polypeptide binding]; other site 445985002514 pyridoxal binding site [chemical binding]; other site 445985002515 ATP binding site [chemical binding]; other site 445985002516 UGMP family protein; Validated; Region: PRK09604 445985002517 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 445985002518 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 445985002519 NodB motif; other site 445985002520 putative active site [active] 445985002521 putative catalytic site [active] 445985002522 Zn binding site [ion binding]; other site 445985002523 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 445985002524 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 445985002525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445985002526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 445985002527 DNA binding residues [nucleotide binding] 445985002528 Rod binding protein; Region: Rod-binding; cl01626 445985002529 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK12706 445985002530 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 445985002531 SAF-like; Region: SAF_2; pfam13144 445985002532 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 445985002533 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 445985002534 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 445985002535 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 445985002536 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 445985002537 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 445985002538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 445985002539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445985002540 active site 445985002541 ribosomal protein L21; Region: L21; TIGR00061 445985002542 hypothetical protein; Provisional; Region: PRK14553 445985002543 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 445985002544 GTPase CgtA; Reviewed; Region: obgE; PRK12299 445985002545 GTP1/OBG; Region: GTP1_OBG; pfam01018 445985002546 Obg GTPase; Region: Obg; cd01898 445985002547 G1 box; other site 445985002548 GTP/Mg2+ binding site [chemical binding]; other site 445985002549 Switch I region; other site 445985002550 G2 box; other site 445985002551 G3 box; other site 445985002552 Switch II region; other site 445985002553 G4 box; other site 445985002554 G5 box; other site 445985002555 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 445985002556 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 445985002557 active site 445985002558 (T/H)XGH motif; other site 445985002559 Transcriptional regulator [Transcription]; Region: LytR; COG1316 445985002560 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 445985002561 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 445985002562 regulatory protein SpoVG; Reviewed; Region: PRK13259 445985002563 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 445985002564 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 445985002565 5S rRNA interface [nucleotide binding]; other site 445985002566 CTC domain interface [polypeptide binding]; other site 445985002567 L16 interface [polypeptide binding]; other site 445985002568 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 445985002569 putative active site [active] 445985002570 catalytic residue [active] 445985002571 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 445985002572 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 445985002573 Ligand Binding Site [chemical binding]; other site 445985002574 FtsH Extracellular; Region: FtsH_ext; pfam06480 445985002575 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 445985002576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985002577 Walker A motif; other site 445985002578 ATP binding site [chemical binding]; other site 445985002579 Walker B motif; other site 445985002580 arginine finger; other site 445985002581 Peptidase family M41; Region: Peptidase_M41; pfam01434 445985002582 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 445985002583 thymidylate kinase; Region: DTMP_kinase; TIGR00041 445985002584 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 445985002585 TMP-binding site; other site 445985002586 ATP-binding site [chemical binding]; other site 445985002587 Family of unknown function (DUF490); Region: DUF490; pfam04357 445985002588 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 445985002589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445985002590 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445985002591 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445985002592 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445985002593 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445985002594 Surface antigen; Region: Bac_surface_Ag; pfam01103 445985002595 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 445985002596 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 445985002597 MutS domain I; Region: MutS_I; pfam01624 445985002598 MutS domain II; Region: MutS_II; pfam05188 445985002599 MutS domain III; Region: MutS_III; pfam05192 445985002600 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 445985002601 Walker A/P-loop; other site 445985002602 ATP binding site [chemical binding]; other site 445985002603 Q-loop/lid; other site 445985002604 ABC transporter signature motif; other site 445985002605 Walker B; other site 445985002606 D-loop; other site 445985002607 H-loop/switch region; other site 445985002608 comF family protein; Region: comF; TIGR00201 445985002609 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445985002610 active site 445985002611 hypothetical protein; Provisional; Region: PRK14630 445985002612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 445985002613 heptamer interface [polypeptide binding]; other site 445985002614 Sm1 motif; other site 445985002615 hexamer interface [polypeptide binding]; other site 445985002616 RNA binding site [nucleotide binding]; other site 445985002617 Sm2 motif; other site 445985002618 transcription termination factor NusA; Region: NusA; TIGR01953 445985002619 NusA N-terminal domain; Region: NusA_N; pfam08529 445985002620 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 445985002621 RNA binding site [nucleotide binding]; other site 445985002622 homodimer interface [polypeptide binding]; other site 445985002623 NusA-like KH domain; Region: KH_5; pfam13184 445985002624 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 445985002625 G-X-X-G motif; other site 445985002626 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 445985002627 translation initiation factor IF-2; Region: IF-2; TIGR00487 445985002628 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 445985002629 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 445985002630 G1 box; other site 445985002631 putative GEF interaction site [polypeptide binding]; other site 445985002632 GTP/Mg2+ binding site [chemical binding]; other site 445985002633 Switch I region; other site 445985002634 G2 box; other site 445985002635 G3 box; other site 445985002636 Switch II region; other site 445985002637 G4 box; other site 445985002638 G5 box; other site 445985002639 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 445985002640 Translation-initiation factor 2; Region: IF-2; pfam11987 445985002641 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 445985002642 ribosome-binding factor A; Region: rbfA; TIGR00082 445985002643 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 445985002644 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 445985002645 RNA binding site [nucleotide binding]; other site 445985002646 active site 445985002647 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 445985002648 16S/18S rRNA binding site [nucleotide binding]; other site 445985002649 S13e-L30e interaction site [polypeptide binding]; other site 445985002650 25S rRNA binding site [nucleotide binding]; other site 445985002651 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 445985002652 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 445985002653 RNase E interface [polypeptide binding]; other site 445985002654 trimer interface [polypeptide binding]; other site 445985002655 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 445985002656 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 445985002657 RNase E interface [polypeptide binding]; other site 445985002658 trimer interface [polypeptide binding]; other site 445985002659 active site 445985002660 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 445985002661 putative nucleic acid binding region [nucleotide binding]; other site 445985002662 G-X-X-G motif; other site 445985002663 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 445985002664 RNA binding site [nucleotide binding]; other site 445985002665 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 445985002666 Predicted permeases [General function prediction only]; Region: COG0795 445985002667 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 445985002668 Predicted permeases [General function prediction only]; Region: COG0795 445985002669 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 445985002670 tRNA-guanine transglycosylase, queuosine-34-forming; Region: Q_tRNA_tgt; TIGR00430 445985002671 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 445985002672 integral membrane protein MviN; Region: mviN; TIGR01695 445985002673 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 445985002674 HEAT repeats; Region: HEAT_2; pfam13646 445985002675 HEAT repeats; Region: HEAT_2; pfam13646 445985002676 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 445985002677 Flavoprotein; Region: Flavoprotein; pfam02441 445985002678 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 445985002679 Protein of unknown function (DUF997); Region: DUF997; cl01614 445985002680 sodium/panthothenate symporter; Provisional; Region: panF; PRK09442 445985002681 Na binding site [ion binding]; other site 445985002682 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 445985002683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 445985002684 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 445985002685 active site 445985002686 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 445985002687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445985002688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445985002689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445985002690 TIGR00255 family protein; Region: TIGR00255 445985002691 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 445985002692 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 445985002693 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 445985002694 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 445985002695 CMP-binding site; other site 445985002696 The sites determining sugar specificity; other site 445985002697 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 445985002698 tRNA delta(2)-isopentenylpyrophosphate transferase; Provisional; Region: miaA; PRK14729 445985002699 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 445985002700 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 445985002701 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 445985002702 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985002703 ATP binding site [chemical binding]; other site 445985002704 putative Mg++ binding site [ion binding]; other site 445985002705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985002706 nucleotide binding region [chemical binding]; other site 445985002707 ATP-binding site [chemical binding]; other site 445985002708 Helicase associated domain (HA2); Region: HA2; pfam04408 445985002709 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 445985002710 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 445985002711 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 445985002712 active site 445985002713 interdomain interaction site; other site 445985002714 putative metal-binding site [ion binding]; other site 445985002715 nucleotide binding site [chemical binding]; other site 445985002716 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 445985002717 domain I; other site 445985002718 phosphate binding site [ion binding]; other site 445985002719 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 445985002720 domain III; other site 445985002721 nucleotide binding site [chemical binding]; other site 445985002722 DNA binding groove [nucleotide binding] 445985002723 catalytic site [active] 445985002724 domain II; other site 445985002725 domain IV; other site 445985002726 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 445985002727 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 445985002728 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 445985002729 active site 445985002730 metal binding site [ion binding]; metal-binding site 445985002731 DNA binding site [nucleotide binding] 445985002732 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 445985002733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985002734 Walker A/P-loop; other site 445985002735 ATP binding site [chemical binding]; other site 445985002736 Q-loop/lid; other site 445985002737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445985002738 ABC transporter signature motif; other site 445985002739 Walker B; other site 445985002740 D-loop; other site 445985002741 H-loop/switch region; other site 445985002742 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 445985002743 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 445985002744 HIGH motif; other site 445985002745 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 445985002746 active site 445985002747 KMSKS motif; other site 445985002748 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 445985002749 tRNA binding surface [nucleotide binding]; other site 445985002750 anticodon binding site; other site 445985002751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985002752 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 445985002753 Walker A motif; other site 445985002754 ATP binding site [chemical binding]; other site 445985002755 Walker B motif; other site 445985002756 arginine finger; other site 445985002757 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 445985002758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445985002759 Walker A motif; other site 445985002760 ATP binding site [chemical binding]; other site 445985002761 Walker B motif; other site 445985002762 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 445985002763 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 445985002764 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 445985002765 active site 445985002766 substrate binding site [chemical binding]; other site 445985002767 metal binding site [ion binding]; metal-binding site 445985002768 excinuclease ABC subunit B; Provisional; Region: PRK05298 445985002769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445985002770 ATP binding site [chemical binding]; other site 445985002771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445985002772 nucleotide binding region [chemical binding]; other site 445985002773 ATP-binding site [chemical binding]; other site 445985002774 Ultra-violet resistance protein B; Region: UvrB; pfam12344 445985002775 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 445985002776 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 445985002777 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 445985002778 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 445985002779 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 445985002780 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 445985002781 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 445985002782 RNA/DNA hybrid binding site [nucleotide binding]; other site 445985002783 active site 445985002784 arginine deiminase; Region: arcA; TIGR01078 445985002785 ornithine carbamoyltransferase; Provisional; Region: PRK04284 445985002786 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 445985002787 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 445985002788 Uncharacterized conserved protein [Function unknown]; Region: COG4748 445985002789 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 445985002790 Uncharacterized conserved protein [Function unknown]; Region: COG3586 445985002791 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985002792 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002793 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002794 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002795 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 445985002796 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002797 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002798 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002799 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002800 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002801 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002802 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985002803 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002804 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985002805 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985002806 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002807 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985002808 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985002809 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002810 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 445985002811 Mlp lipoprotein family; Region: Mlp; pfam03304 445985002812 ERF superfamily; Region: ERF; pfam04404 445985002813 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002814 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002815 AAA domain; Region: AAA_31; pfam13614 445985002816 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002817 P-loop; other site 445985002818 Magnesium ion binding site [ion binding]; other site 445985002819 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002820 Magnesium ion binding site [ion binding]; other site 445985002821 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002822 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 445985002823 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 445985002824 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985002825 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002826 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445985002827 active site 445985002828 catalytic residues [active] 445985002829 Int/Topo IB signature motif; other site 445985002830 DNA binding site [nucleotide binding] 445985002831 Erp protein C-terminus; Region: Erp_C; pfam06780 445985002832 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985002833 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002834 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985002835 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002836 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002837 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002838 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 445985002839 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002840 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002841 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002842 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002843 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002844 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002845 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985002846 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002847 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985002848 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985002849 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985002850 DUF276; Region: DUF276; pfam03434 445985002851 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985002852 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002853 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985002854 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985002855 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002856 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 445985002857 Mlp lipoprotein family; Region: Mlp; pfam03304 445985002858 ERF superfamily; Region: ERF; pfam04404 445985002859 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002860 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002861 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002862 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002863 P-loop; other site 445985002864 Magnesium ion binding site [ion binding]; other site 445985002865 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002866 Magnesium ion binding site [ion binding]; other site 445985002867 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002868 membrane glycoprotein; Provisional; Region: PHA03332 445985002869 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 445985002870 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985002871 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002872 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445985002873 active site 445985002874 catalytic residues [active] 445985002875 DNA binding site [nucleotide binding] 445985002876 Int/Topo IB signature motif; other site 445985002877 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 445985002878 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985002879 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002880 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 445985002881 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002882 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002883 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985002884 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 445985002885 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985002886 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985002887 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985002888 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985002889 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985002890 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985002891 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 445985002892 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985002893 Protein of unknown function (DUF693); Region: DUF693; pfam05113 445985002894 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 445985002895 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985002896 DUF276; Region: DUF276; pfam03434 445985002897 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985002898 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985002899 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 445985002900 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 445985002901 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002902 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 445985002903 Mlp lipoprotein family; Region: Mlp; pfam03304 445985002904 ERF superfamily; Region: ERF; pfam04404 445985002905 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002906 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002907 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002909 P-loop; other site 445985002910 Magnesium ion binding site [ion binding]; other site 445985002911 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002912 Magnesium ion binding site [ion binding]; other site 445985002913 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002914 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 445985002915 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 445985002916 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002917 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445985002918 active site 445985002919 catalytic residues [active] 445985002920 DNA binding site [nucleotide binding] 445985002921 Int/Topo IB signature motif; other site 445985002922 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 445985002923 Erp protein C-terminus; Region: Erp_C; pfam06780 445985002924 Protein of unknown function (DUF643); Region: DUF643; pfam04867 445985002925 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985002926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 445985002927 adenine deaminase; Region: ade; TIGR01178 445985002928 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 445985002929 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 445985002930 active site 445985002931 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 445985002932 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002933 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445985002934 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002935 Magnesium ion binding site [ion binding]; other site 445985002936 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002937 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002938 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002939 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 445985002940 hypothetical protein; Provisional; Region: PRK12472 445985002941 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002942 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002943 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002944 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002945 P-loop; other site 445985002946 Magnesium ion binding site [ion binding]; other site 445985002947 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002948 Magnesium ion binding site [ion binding]; other site 445985002949 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002950 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 445985002951 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 445985002952 Transcription factor Tfb2; Region: Tfb2; cl04289 445985002953 Right handed beta helix region; Region: Beta_helix; pfam13229 445985002954 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985002955 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985002956 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002957 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002958 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002959 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 445985002960 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 445985002961 Walker A motif; other site 445985002962 ATP binding site [chemical binding]; other site 445985002963 Walker B motif; other site 445985002964 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002965 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002968 P-loop; other site 445985002969 Magnesium ion binding site [ion binding]; other site 445985002970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002971 Magnesium ion binding site [ion binding]; other site 445985002972 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002973 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985002974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 445985002975 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 445985002976 Probable transposase; Region: OrfB_IS605; pfam01385 445985002977 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 445985002978 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002979 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002980 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002981 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002982 P-loop; other site 445985002983 Magnesium ion binding site [ion binding]; other site 445985002984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002985 Magnesium ion binding site [ion binding]; other site 445985002986 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985002987 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002988 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 445985002989 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002990 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985002991 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985002992 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002993 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985002994 P-loop; other site 445985002995 Magnesium ion binding site [ion binding]; other site 445985002996 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 445985002997 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985002998 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985002999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985003000 P-loop; other site 445985003001 Magnesium ion binding site [ion binding]; other site 445985003002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985003003 Magnesium ion binding site [ion binding]; other site 445985003004 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985003005 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985003006 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 445985003007 Isochorismatase family; Region: Isochorismatase; pfam00857 445985003008 catalytic triad [active] 445985003009 conserved cis-peptide bond; other site 445985003010 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985003011 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985003012 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 445985003013 DUF276; Region: DUF276; pfam03434 445985003014 Protein of unknown function (DUF735); Region: DUF735; pfam05246 445985003015 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985003016 Protein of unknown function (DUF685); Region: DUF685; pfam05085 445985003017 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 445985003018 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 445985003019 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 445985003020 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985003021 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985003022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985003023 P-loop; other site 445985003024 Magnesium ion binding site [ion binding]; other site 445985003025 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985003026 Magnesium ion binding site [ion binding]; other site 445985003027 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985003028 Protein of unknown function, DUF261; Region: DUF261; pfam03196 445985003029 Decorin binding protein; Region: Decorin_bind; pfam02352 445985003030 Decorin binding protein; Region: Decorin_bind; pfam02352 445985003031 Protein of unknown function, DUF603; Region: DUF603; pfam04645 445985003032 Phage terminase large subunit; Region: Terminase_3; cl12054 445985003033 Terminase-like family; Region: Terminase_6; pfam03237 445985003034 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 445985003035 peptide binding site [polypeptide binding]; other site 445985003036 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 445985003037 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 445985003038 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 445985003039 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 445985003040 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 445985003041 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 445985003042 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 445985003043 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 445985003044 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 445985003045 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 445985003046 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985003047 Invariant surface glycoprotein; Region: ISG65-75; pfam11727 445985003048 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 445985003049 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985003050 OMS28 porin; Region: OMS28_porin; pfam03532 445985003051 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 445985003052 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985003053 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 445985003054 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985003055 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 445985003056 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 445985003057 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445985003058 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985003059 P-loop; other site 445985003060 Magnesium ion binding site [ion binding]; other site 445985003061 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445985003062 Magnesium ion binding site [ion binding]; other site 445985003063 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 445985003064 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985003065 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 445985003066 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 445985003067 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002