-- dump date 20140619_004349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521010000001 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000002 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000003 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000004 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000005 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000006 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000007 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000008 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000009 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000010 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000011 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000012 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000013 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000014 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000015 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000016 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000017 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000018 DUF276; Region: DUF276; pfam03434 521010000019 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000020 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000021 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000022 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000023 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000024 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 521010000025 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000026 ERF superfamily; Region: ERF; pfam04404 521010000027 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000028 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000029 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000030 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000031 P-loop; other site 521010000032 Magnesium ion binding site [ion binding]; other site 521010000033 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000034 Magnesium ion binding site [ion binding]; other site 521010000035 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000036 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000037 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000038 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000039 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000040 active site 521010000041 catalytic residues [active] 521010000042 DNA binding site [nucleotide binding] 521010000043 Int/Topo IB signature motif; other site 521010000044 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000045 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000046 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000047 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000048 Terminase-like family; Region: Terminase_6; pfam03237 521010000049 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000050 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000051 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000052 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000053 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000054 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000055 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000056 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000057 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000058 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000059 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000060 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000061 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000062 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000063 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000064 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000065 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000066 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000067 DUF276; Region: DUF276; pfam03434 521010000068 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000069 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000070 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000071 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000072 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000073 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 521010000074 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000075 ERF superfamily; Region: ERF; pfam04404 521010000076 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000077 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000080 P-loop; other site 521010000081 Magnesium ion binding site [ion binding]; other site 521010000082 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000083 Magnesium ion binding site [ion binding]; other site 521010000084 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000085 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 521010000086 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000087 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000088 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000089 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000090 active site 521010000091 catalytic residues [active] 521010000092 DNA binding site [nucleotide binding] 521010000093 Int/Topo IB signature motif; other site 521010000094 Borrelia outer surface protein E; Region: OspE; pfam02471 521010000095 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000096 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000097 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000098 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000099 Terminase-like family; Region: Terminase_6; pfam03237 521010000100 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000101 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000102 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000103 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000104 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000105 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000106 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000107 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000108 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000109 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000110 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000111 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000112 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000113 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000114 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000115 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000116 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000117 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000118 DUF276; Region: DUF276; pfam03434 521010000119 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000120 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000121 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000122 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000123 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000124 ERF superfamily; Region: ERF; pfam04404 521010000125 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000126 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000127 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000128 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000129 P-loop; other site 521010000130 Magnesium ion binding site [ion binding]; other site 521010000131 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000132 Magnesium ion binding site [ion binding]; other site 521010000133 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000134 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 521010000135 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 521010000136 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000137 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000138 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000139 active site 521010000140 catalytic residues [active] 521010000141 DNA binding site [nucleotide binding] 521010000142 Int/Topo IB signature motif; other site 521010000143 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000144 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000145 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000146 Terminase-like family; Region: Terminase_6; pfam03237 521010000147 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000148 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000149 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000150 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000151 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000152 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000153 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000154 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000155 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000156 ERF superfamily; Region: ERF; pfam04404 521010000157 ERF superfamily; Region: ERF; pfam04404 521010000158 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000159 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000160 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000162 P-loop; other site 521010000163 Magnesium ion binding site [ion binding]; other site 521010000164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000165 Magnesium ion binding site [ion binding]; other site 521010000166 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000167 AAA domain; Region: AAA_13; pfam13166 521010000168 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000169 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000170 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000171 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000172 active site 521010000173 catalytic residues [active] 521010000174 DNA binding site [nucleotide binding] 521010000175 Int/Topo IB signature motif; other site 521010000176 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000177 TM2 domain; Region: TM2; pfam05154 521010000178 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000179 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000180 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000181 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000182 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000183 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000184 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000185 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000186 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000187 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000188 Magnesium ion binding site [ion binding]; other site 521010000189 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000190 Haemolysin XhlA; Region: XhlA; pfam10779 521010000191 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000192 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000193 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000194 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000195 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000196 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000197 Borrelia outer surface protein E; Region: OspE; pfam02471 521010000198 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521010000199 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000200 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000201 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000202 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521010000203 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000204 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000205 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000206 P-loop; other site 521010000207 Magnesium ion binding site [ion binding]; other site 521010000208 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000209 Magnesium ion binding site [ion binding]; other site 521010000210 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000211 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000212 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000213 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000214 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 521010000215 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000216 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000217 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000218 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000219 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000220 DUF276; Region: DUF276; pfam03434 521010000221 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000222 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000223 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000224 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000225 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000226 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000227 Terminase-like family; Region: Terminase_6; pfam03237 521010000228 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000229 Terminase-like family; Region: Terminase_6; pfam03237 521010000230 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000231 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000232 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000233 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000234 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000235 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000236 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000237 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000240 P-loop; other site 521010000241 Magnesium ion binding site [ion binding]; other site 521010000242 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000243 Magnesium ion binding site [ion binding]; other site 521010000244 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000245 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 521010000246 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000247 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000248 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000249 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000250 Terminase-like family; Region: Terminase_6; pfam03237 521010000251 Acylphosphatase; Region: Acylphosphatase; cl00551 521010000252 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 521010000253 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 521010000254 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 521010000255 methionine cluster; other site 521010000256 active site 521010000257 phosphorylation site [posttranslational modification] 521010000258 metal binding site [ion binding]; metal-binding site 521010000259 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 521010000260 active site 521010000261 Uncharacterized conserved protein [Function unknown]; Region: COG3589 521010000262 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 521010000263 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000264 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000265 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000266 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000267 P-loop; other site 521010000268 Magnesium ion binding site [ion binding]; other site 521010000269 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000270 Magnesium ion binding site [ion binding]; other site 521010000271 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000272 Protein of unknown function (DUF1187); Region: DUF1187; cl11638 521010000273 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010000274 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010000275 peptide binding site [polypeptide binding]; other site 521010000276 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 521010000277 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 521010000278 active site 521010000279 GMP synthase; Reviewed; Region: guaA; PRK00074 521010000280 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521010000281 AMP/PPi binding site [chemical binding]; other site 521010000282 candidate oxyanion hole; other site 521010000283 catalytic triad [active] 521010000284 potential glutamine specificity residues [chemical binding]; other site 521010000285 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521010000286 ATP Binding subdomain [chemical binding]; other site 521010000287 Ligand Binding sites [chemical binding]; other site 521010000288 Dimerization subdomain; other site 521010000289 Lipoprotein; Region: Lipoprotein_6; pfam01441 521010000290 Permease family; Region: Xan_ur_permease; pfam00860 521010000291 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 521010000292 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 521010000293 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521010000294 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521010000295 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 521010000296 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 521010000297 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521010000298 active site turn [active] 521010000299 phosphorylation site [posttranslational modification] 521010000300 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000301 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000302 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000303 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000304 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000305 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000306 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000307 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000308 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000309 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000310 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000311 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000312 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000313 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000314 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000315 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000316 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000317 DUF276; Region: DUF276; pfam03434 521010000318 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000319 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000320 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000321 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000322 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000323 Uncharacterized conserved protein [Function unknown]; Region: COG2433 521010000324 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000325 ERF superfamily; Region: ERF; pfam04404 521010000326 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000327 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000328 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000330 P-loop; other site 521010000331 Magnesium ion binding site [ion binding]; other site 521010000332 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000333 Magnesium ion binding site [ion binding]; other site 521010000334 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000335 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 521010000336 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000337 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000338 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000339 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000340 active site 521010000341 catalytic residues [active] 521010000342 DNA binding site [nucleotide binding] 521010000343 Int/Topo IB signature motif; other site 521010000344 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000345 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000346 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000347 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000348 Terminase-like family; Region: Terminase_6; pfam03237 521010000349 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000350 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000351 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000352 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000353 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000354 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000355 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000356 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000357 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000358 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000359 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000360 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000361 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000362 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000363 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000364 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000365 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000366 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000367 DUF276; Region: DUF276; pfam03434 521010000368 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000369 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000370 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000371 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000372 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000373 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000374 ERF superfamily; Region: ERF; pfam04404 521010000375 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000376 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000377 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000378 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000379 Magnesium ion binding site [ion binding]; other site 521010000380 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000381 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010000382 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000383 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000384 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000385 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000386 active site 521010000387 catalytic residues [active] 521010000388 DNA binding site [nucleotide binding] 521010000389 Int/Topo IB signature motif; other site 521010000390 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000391 Protein of unknown function (DUF643); Region: DUF643; pfam04867 521010000392 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000393 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000394 Terminase-like family; Region: Terminase_6; pfam03237 521010000395 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000396 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000397 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000398 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000399 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000400 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000401 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000402 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000403 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000404 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000405 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000406 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000407 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 521010000408 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000409 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000410 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000411 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000412 DUF276; Region: DUF276; pfam03434 521010000413 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000414 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000415 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000416 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 521010000417 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000418 Mlp lipoprotein family; Region: Mlp; pfam03304 521010000419 ERF superfamily; Region: ERF; pfam04404 521010000420 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000421 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000422 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000423 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000424 P-loop; other site 521010000425 Magnesium ion binding site [ion binding]; other site 521010000426 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000427 Magnesium ion binding site [ion binding]; other site 521010000428 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000429 AAA domain; Region: AAA_13; pfam13166 521010000430 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000431 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000432 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000433 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000434 active site 521010000435 catalytic residues [active] 521010000436 DNA binding site [nucleotide binding] 521010000437 Int/Topo IB signature motif; other site 521010000438 TM2 domain; Region: TM2; pfam05154 521010000439 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000440 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000441 Terminase-like family; Region: Terminase_6; pfam03237 521010000442 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000443 Z1 domain; Region: Z1; pfam10593 521010000444 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000445 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000446 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000447 P-loop; other site 521010000448 Magnesium ion binding site [ion binding]; other site 521010000449 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000450 Magnesium ion binding site [ion binding]; other site 521010000451 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000452 ERF superfamily; Region: ERF; pfam04404 521010000453 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000454 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010000455 putative allyl alcohol dehydrogenase; Provisional; Region: PLN03154 521010000456 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 521010000457 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521010000458 active site 521010000459 catalytic residues [active] 521010000460 DNA binding site [nucleotide binding] 521010000461 Int/Topo IB signature motif; other site 521010000462 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 521010000463 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 521010000464 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000465 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 521010000466 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000467 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000468 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000469 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521010000470 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000471 P-loop; other site 521010000472 Magnesium ion binding site [ion binding]; other site 521010000473 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000474 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 521010000475 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 521010000477 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521010000478 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 521010000479 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000480 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000481 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000483 P-loop; other site 521010000484 Magnesium ion binding site [ion binding]; other site 521010000485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000486 Magnesium ion binding site [ion binding]; other site 521010000487 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000488 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000489 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000490 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 521010000491 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000492 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000493 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000494 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000495 P-loop; other site 521010000496 Magnesium ion binding site [ion binding]; other site 521010000497 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000498 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000499 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000500 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 521010000501 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000502 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 521010000504 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 521010000505 Probable transposase; Region: OrfB_IS605; pfam01385 521010000506 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 521010000507 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000508 Erp protein C-terminus; Region: Erp_C; pfam06780 521010000509 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000510 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 521010000512 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000513 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000514 adenine deaminase; Region: ade; TIGR01178 521010000515 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521010000516 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 521010000517 active site 521010000518 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 521010000519 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000520 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000521 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000522 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000523 P-loop; other site 521010000524 Magnesium ion binding site [ion binding]; other site 521010000525 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000526 Magnesium ion binding site [ion binding]; other site 521010000527 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000528 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000529 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000530 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 521010000531 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000532 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 521010000533 DUF276; Region: DUF276; pfam03434 521010000534 Protein of unknown function (DUF735); Region: DUF735; pfam05246 521010000535 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000536 Protein of unknown function (DUF685); Region: DUF685; pfam05085 521010000537 holin, BlyA family; Region: Holin_BlyA; cl15434 521010000538 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000539 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 521010000540 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 521010000541 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000542 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000543 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000544 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000545 P-loop; other site 521010000546 Magnesium ion binding site [ion binding]; other site 521010000547 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000548 Magnesium ion binding site [ion binding]; other site 521010000549 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000550 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000551 Decorin binding protein; Region: Decorin_bind; pfam02352 521010000552 Decorin binding protein; Region: Decorin_bind; pfam02352 521010000553 Protein of unknown function, DUF603; Region: DUF603; pfam04645 521010000554 Phage terminase large subunit; Region: Terminase_3; cl12054 521010000555 Terminase-like family; Region: Terminase_6; pfam03237 521010000556 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010000557 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010000558 peptide binding site [polypeptide binding]; other site 521010000559 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 521010000560 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 521010000561 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 521010000562 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 521010000563 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 521010000564 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 521010000565 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 521010000566 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 521010000567 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 521010000568 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 521010000569 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 521010000570 Protein of unknown function (DUF693); Region: DUF693; pfam05113 521010000571 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 521010000572 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 521010000573 OMS28 porin; Region: OMS28_porin; pfam03532 521010000574 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 521010000575 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521010000576 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000577 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010000578 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010000579 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000580 P-loop; other site 521010000581 Magnesium ion binding site [ion binding]; other site 521010000582 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010000583 Magnesium ion binding site [ion binding]; other site 521010000584 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000585 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000586 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000587 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 521010000588 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 521010000589 Right handed beta helix region; Region: Beta_helix; pfam13229 521010000590 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 521010000591 Protein of unknown function, DUF261; Region: DUF261; pfam03196 521010000592 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000593 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010000594 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010000595 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 521010000596 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521010000597 Walker A motif; other site 521010000598 ATP binding site [chemical binding]; other site 521010000599 Walker B motif; other site 521010000600 AAA domain; Region: AAA_13; pfam13166 521010000601 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 521010000602 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 521010000603 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 521010000604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521010000605 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 521010000606 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521010000607 active site 521010000608 substrate binding site [chemical binding]; other site 521010000609 metal binding site [ion binding]; metal-binding site 521010000610 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521010000611 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521010000612 active site 521010000613 HIGH motif; other site 521010000614 dimer interface [polypeptide binding]; other site 521010000615 KMSKS motif; other site 521010000616 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 521010000617 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521010000618 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521010000619 TIGR00159 family protein; Region: TIGR00159 521010000620 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521010000621 YbbR-like protein; Region: YbbR; pfam07949 521010000622 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 521010000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 521010000624 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 521010000625 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521010000626 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 521010000627 dimerization interface 3.5A [polypeptide binding]; other site 521010000628 active site 521010000629 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 521010000630 primosomal protein N' Region: priA; TIGR00595 521010000631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010000632 ATP binding site [chemical binding]; other site 521010000633 putative Mg++ binding site [ion binding]; other site 521010000634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010000635 nucleotide binding region [chemical binding]; other site 521010000636 ATP-binding site [chemical binding]; other site 521010000637 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 521010000638 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 521010000639 Sugar specificity; other site 521010000640 Pyrimidine base specificity; other site 521010000641 ATP-binding site [chemical binding]; other site 521010000642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521010000643 active site residue [active] 521010000644 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521010000645 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521010000646 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 521010000647 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521010000648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521010000649 active site 521010000650 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent...; Region: Pyrophosphate_PFK; cd00765 521010000651 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 521010000652 active site 521010000653 pyrophosphate binding site [ion binding]; other site 521010000654 dimerization interface [polypeptide binding]; other site 521010000655 fructose-6-phosphate binding site; other site 521010000656 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 521010000657 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 521010000658 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521010000659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010000660 Walker A motif; other site 521010000661 ATP binding site [chemical binding]; other site 521010000662 Walker B motif; other site 521010000663 arginine finger; other site 521010000664 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521010000665 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 521010000666 RuvA N terminal domain; Region: RuvA_N; pfam01330 521010000667 Reversibly glycosylated polypeptide; Region: RGP; cl07847 521010000668 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 521010000669 hypothetical protein; Validated; Region: PRK00110 521010000670 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521010000671 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521010000672 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521010000673 homodimer interface [polypeptide binding]; other site 521010000674 NADP binding site [chemical binding]; other site 521010000675 substrate binding site [chemical binding]; other site 521010000676 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 521010000677 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521010000678 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 521010000679 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521010000680 Catalytic site [active] 521010000681 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521010000682 PEGA domain; Region: PEGA; pfam08308 521010000683 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521010000684 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521010000685 SmpB-tmRNA interface; other site 521010000686 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 521010000687 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 521010000688 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 521010000689 CAP-like domain; other site 521010000690 active site 521010000691 primary dimer interface [polypeptide binding]; other site 521010000692 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 521010000693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 521010000694 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521010000695 anchoring element; other site 521010000696 dimer interface [polypeptide binding]; other site 521010000697 ATP binding site [chemical binding]; other site 521010000698 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 521010000699 active site 521010000700 putative metal-binding site [ion binding]; other site 521010000701 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521010000702 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521010000703 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521010000704 putative acyl-acceptor binding pocket; other site 521010000705 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 521010000706 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521010000707 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 521010000708 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 521010000709 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 521010000710 PhoU domain; Region: PhoU; pfam01895 521010000711 PhoU domain; Region: PhoU; pfam01895 521010000712 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010000713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010000714 Walker A/P-loop; other site 521010000715 ATP binding site [chemical binding]; other site 521010000716 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010000717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010000718 ABC transporter signature motif; other site 521010000719 Walker B; other site 521010000720 D-loop; other site 521010000721 H-loop/switch region; other site 521010000722 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 521010000723 RNA/DNA hybrid binding site [nucleotide binding]; other site 521010000724 active site 521010000725 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 521010000726 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 521010000727 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 521010000728 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521010000729 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521010000730 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 521010000731 ligand binding site [chemical binding]; other site 521010000732 active site 521010000733 UGI interface [polypeptide binding]; other site 521010000734 catalytic site [active] 521010000735 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521010000736 triosephosphate isomerase; Provisional; Region: PRK14565 521010000737 substrate binding site [chemical binding]; other site 521010000738 dimer interface [polypeptide binding]; other site 521010000739 catalytic triad [active] 521010000740 Phosphoglycerate kinase; Region: PGK; pfam00162 521010000741 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521010000742 substrate binding site [chemical binding]; other site 521010000743 hinge regions; other site 521010000744 ADP binding site [chemical binding]; other site 521010000745 catalytic site [active] 521010000746 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 521010000747 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 521010000748 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 521010000749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000750 binding surface 521010000751 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010000752 TPR motif; other site 521010000753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000754 TPR motif; other site 521010000755 binding surface 521010000756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000757 TPR repeat; Region: TPR_11; pfam13414 521010000758 binding surface 521010000759 TPR motif; other site 521010000760 FOG: CBS domain [General function prediction only]; Region: COG0517 521010000761 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521010000762 Transporter associated domain; Region: CorC_HlyC; smart01091 521010000763 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 521010000764 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521010000765 catalytic residues [active] 521010000766 RNA methyltransferase, RsmE family; Region: TIGR00046 521010000767 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 521010000768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 521010000769 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521010000770 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521010000771 PASTA domain; Region: PASTA; smart00740 521010000772 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 521010000773 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521010000774 putative active site [active] 521010000775 substrate binding site [chemical binding]; other site 521010000776 putative cosubstrate binding site; other site 521010000777 catalytic site [active] 521010000778 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521010000779 substrate binding site [chemical binding]; other site 521010000780 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521010000781 active site 521010000782 catalytic residues [active] 521010000783 metal binding site [ion binding]; metal-binding site 521010000784 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521010000785 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521010000786 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 521010000787 active site 521010000788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010000789 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521010000790 active site 521010000791 motif I; other site 521010000792 motif II; other site 521010000793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 521010000794 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 521010000795 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 521010000796 Divergent PAP2 family; Region: DUF212; cl00855 521010000797 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 521010000798 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521010000799 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 521010000800 RF-1 domain; Region: RF-1; pfam00472 521010000801 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 521010000802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521010000803 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521010000804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521010000805 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521010000806 Walker A/P-loop; other site 521010000807 ATP binding site [chemical binding]; other site 521010000808 Q-loop/lid; other site 521010000809 ABC transporter signature motif; other site 521010000810 Walker B; other site 521010000811 D-loop; other site 521010000812 H-loop/switch region; other site 521010000813 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521010000814 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521010000815 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521010000816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521010000817 catalytic residue [active] 521010000818 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 521010000819 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 521010000820 active site 521010000821 trimerization site [polypeptide binding]; other site 521010000822 Mg chelatase-related protein; Region: TIGR00368 521010000823 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521010000824 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 521010000825 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 521010000826 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 521010000827 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521010000828 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521010000829 NAD binding site [chemical binding]; other site 521010000830 dimer interface [polypeptide binding]; other site 521010000831 substrate binding site [chemical binding]; other site 521010000832 GTP-binding protein LepA; Provisional; Region: PRK05433 521010000833 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521010000834 Switch I region; other site 521010000835 G2 box; other site 521010000836 putative GEF interaction site [polypeptide binding]; other site 521010000837 G3 box; other site 521010000838 Switch II region; other site 521010000839 GTP/Mg2+ binding site [chemical binding]; other site 521010000840 G4 box; other site 521010000841 G5 box; other site 521010000842 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 521010000843 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521010000844 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521010000845 V-type ATP synthase subunit K; Validated; Region: PRK06649 521010000846 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010000847 V-type ATP synthase subunit D; Provisional; Region: PRK02195 521010000848 V-type ATP synthase subunit B; Provisional; Region: PRK02118 521010000849 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521010000850 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 521010000851 Walker A motif homologous position; other site 521010000852 Walker B motif; other site 521010000853 V-type ATP synthase subunit A; Provisional; Region: PRK04192 521010000854 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521010000855 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 521010000856 Walker A motif/ATP binding site; other site 521010000857 Walker B motif; other site 521010000858 V-type ATP synthase subunit E; Provisional; Region: PRK01558 521010000859 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 521010000860 MutS2 family protein; Region: mutS2; TIGR01069 521010000861 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 521010000862 Walker A/P-loop; other site 521010000863 ATP binding site [chemical binding]; other site 521010000864 Q-loop/lid; other site 521010000865 ABC transporter signature motif; other site 521010000866 Walker B; other site 521010000867 D-loop; other site 521010000868 H-loop/switch region; other site 521010000869 Smr domain; Region: Smr; pfam01713 521010000870 ribosome small subunit-dependent GTPase A; Region: TIGR00157 521010000871 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521010000872 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521010000873 GTP/Mg2+ binding site [chemical binding]; other site 521010000874 G4 box; other site 521010000875 G5 box; other site 521010000876 G1 box; other site 521010000877 Switch I region; other site 521010000878 G2 box; other site 521010000879 G3 box; other site 521010000880 Switch II region; other site 521010000881 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 521010000882 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521010000883 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 521010000884 putative dimer interface [polypeptide binding]; other site 521010000885 putative anticodon binding site; other site 521010000886 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521010000887 homodimer interface [polypeptide binding]; other site 521010000888 motif 1; other site 521010000889 motif 2; other site 521010000890 active site 521010000891 motif 3; other site 521010000892 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 521010000893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010000894 active site 521010000895 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521010000896 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521010000897 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521010000898 protein binding site [polypeptide binding]; other site 521010000899 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521010000900 protein binding site [polypeptide binding]; other site 521010000901 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521010000902 active site 521010000903 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 521010000904 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 521010000905 putative RNA binding site [nucleotide binding]; other site 521010000906 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 521010000907 SurA N-terminal domain; Region: SurA_N; pfam09312 521010000908 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521010000909 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 521010000910 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 521010000911 dimer interface [polypeptide binding]; other site 521010000912 active site 521010000913 replicative DNA helicase; Region: DnaB; TIGR00665 521010000914 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521010000915 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521010000916 Walker A motif; other site 521010000917 ATP binding site [chemical binding]; other site 521010000918 Walker B motif; other site 521010000919 DNA binding loops [nucleotide binding] 521010000920 ribosomal protein L9; Region: L9; TIGR00158 521010000921 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521010000922 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521010000923 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 521010000924 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521010000925 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521010000926 dimer interface [polypeptide binding]; other site 521010000927 ssDNA binding site [nucleotide binding]; other site 521010000928 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521010000929 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 521010000930 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 521010000931 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 521010000932 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521010000933 active site turn [active] 521010000934 phosphorylation site [posttranslational modification] 521010000935 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 521010000936 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 521010000937 RIP metalloprotease RseP; Region: TIGR00054 521010000938 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521010000939 active site 521010000940 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521010000941 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521010000942 protein binding site [polypeptide binding]; other site 521010000943 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521010000944 putative substrate binding region [chemical binding]; other site 521010000945 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 521010000946 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521010000947 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 521010000948 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 521010000949 catalytic residue [active] 521010000950 putative FPP diphosphate binding site; other site 521010000951 putative FPP binding hydrophobic cleft; other site 521010000952 dimer interface [polypeptide binding]; other site 521010000953 putative IPP diphosphate binding site; other site 521010000954 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521010000955 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 521010000956 hinge region; other site 521010000957 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 521010000958 Elongation factor TS; Region: EF_TS; pfam00889 521010000959 Elongation factor TS; Region: EF_TS; pfam00889 521010000960 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521010000961 rRNA interaction site [nucleotide binding]; other site 521010000962 S8 interaction site; other site 521010000963 putative laminin-1 binding site; other site 521010000964 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 521010000965 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521010000966 RNA binding site [nucleotide binding]; other site 521010000967 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 521010000968 RNA binding site [nucleotide binding]; other site 521010000969 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 521010000970 RNA binding site [nucleotide binding]; other site 521010000971 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 521010000972 RNA binding site [nucleotide binding]; other site 521010000973 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 521010000974 RNA binding site [nucleotide binding]; other site 521010000975 cytidylate kinase; Region: cmk; TIGR00017 521010000976 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521010000977 CMP-binding site; other site 521010000978 The sites determining sugar specificity; other site 521010000979 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521010000980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521010000981 RNA binding surface [nucleotide binding]; other site 521010000982 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 521010000983 active site 521010000984 recombinase A; Provisional; Region: recA; PRK09354 521010000985 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521010000986 hexamer interface [polypeptide binding]; other site 521010000987 Walker A motif; other site 521010000988 ATP binding site [chemical binding]; other site 521010000989 Walker B motif; other site 521010000990 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 521010000991 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521010000992 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521010000993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000994 binding surface 521010000995 TPR motif; other site 521010000996 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010000997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010000998 TPR motif; other site 521010000999 binding surface 521010001000 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 521010001001 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 521010001002 dimer interface [polypeptide binding]; other site 521010001003 motif 1; other site 521010001004 active site 521010001005 motif 2; other site 521010001006 motif 3; other site 521010001007 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521010001008 anticodon binding site; other site 521010001009 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521010001010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521010001011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521010001012 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 521010001013 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 521010001014 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521010001015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521010001016 acyl-activating enzyme (AAE) consensus motif; other site 521010001017 CoA binding site [chemical binding]; other site 521010001018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521010001019 AMP binding site [chemical binding]; other site 521010001020 active site 521010001021 CoA binding site [chemical binding]; other site 521010001022 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521010001023 Protein export membrane protein; Region: SecD_SecF; cl14618 521010001024 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 521010001025 HlyD family secretion protein; Region: HlyD_3; pfam13437 521010001026 Outer membrane efflux protein; Region: OEP; pfam02321 521010001027 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 521010001028 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 521010001029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001030 dimer interface [polypeptide binding]; other site 521010001031 conserved gate region; other site 521010001032 putative PBP binding loops; other site 521010001033 ABC-ATPase subunit interface; other site 521010001034 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 521010001035 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 521010001036 Walker A/P-loop; other site 521010001037 ATP binding site [chemical binding]; other site 521010001038 Q-loop/lid; other site 521010001039 ABC transporter signature motif; other site 521010001040 Walker B; other site 521010001041 D-loop; other site 521010001042 H-loop/switch region; other site 521010001043 flagellin; Provisional; Region: PRK12803 521010001044 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521010001045 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521010001046 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 521010001047 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 521010001048 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 521010001049 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 521010001050 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 521010001051 active site 521010001052 dimer interface [polypeptide binding]; other site 521010001053 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 521010001054 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 521010001055 active site 521010001056 trimer interface [polypeptide binding]; other site 521010001057 allosteric site; other site 521010001058 active site lid [active] 521010001059 hexamer (dimer of trimers) interface [polypeptide binding]; other site 521010001060 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 521010001061 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 521010001062 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 521010001063 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 521010001064 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 521010001065 SEC-C motif; Region: SEC-C; pfam02810 521010001066 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 521010001067 alanine racemase; Region: alr; TIGR00492 521010001068 active site 521010001069 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521010001070 dimer interface [polypeptide binding]; other site 521010001071 substrate binding site [chemical binding]; other site 521010001072 catalytic residues [active] 521010001073 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521010001074 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 521010001075 Uncharacterized conserved protein [Function unknown]; Region: COG1306 521010001076 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 521010001077 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521010001078 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521010001079 ligand binding site [chemical binding]; other site 521010001080 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 521010001081 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521010001082 rRNA binding site [nucleotide binding]; other site 521010001083 predicted 30S ribosome binding site; other site 521010001084 Oxygen tolerance; Region: BatD; pfam13584 521010001085 TPR repeat; Region: TPR_11; pfam13414 521010001086 Bacterial SH3 domain homologues; Region: SH3b; smart00287 521010001087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001088 binding surface 521010001089 TPR motif; other site 521010001090 TPR repeat; Region: TPR_11; pfam13414 521010001091 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521010001092 metal ion-dependent adhesion site (MIDAS); other site 521010001093 Aerotolerance regulator N-terminal; Region: BatA; cl06567 521010001094 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 521010001095 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 521010001096 metal ion-dependent adhesion site (MIDAS); other site 521010001097 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521010001098 Protein of unknown function DUF58; Region: DUF58; pfam01882 521010001099 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 521010001100 MoxR-like ATPases [General function prediction only]; Region: COG0714 521010001101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001102 Walker A motif; other site 521010001103 ATP binding site [chemical binding]; other site 521010001104 Walker B motif; other site 521010001105 arginine finger; other site 521010001106 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 521010001107 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 521010001108 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 521010001109 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 521010001110 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 521010001111 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 521010001112 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 521010001113 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 521010001114 trmE is a tRNA modification GTPase; Region: trmE; cd04164 521010001115 G1 box; other site 521010001116 GTP/Mg2+ binding site [chemical binding]; other site 521010001117 Switch I region; other site 521010001118 G2 box; other site 521010001119 Switch II region; other site 521010001120 G3 box; other site 521010001121 G4 box; other site 521010001122 G5 box; other site 521010001123 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 521010001124 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 521010001125 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 521010001126 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521010001127 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 521010001128 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521010001129 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 521010001130 flagellar assembly protein FliW; Provisional; Region: PRK13285 521010001131 carbon storage regulator (csrA); Region: csrA; TIGR00202 521010001132 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 521010001133 Glycoprotease family; Region: Peptidase_M22; pfam00814 521010001134 tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150 521010001135 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521010001136 23S rRNA binding site [nucleotide binding]; other site 521010001137 L21 binding site [polypeptide binding]; other site 521010001138 L13 binding site [polypeptide binding]; other site 521010001139 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 521010001140 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 521010001141 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521010001142 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521010001143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521010001144 active site 521010001145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001146 binding surface 521010001147 TPR motif; other site 521010001148 TPR repeat; Region: TPR_11; pfam13414 521010001149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001150 binding surface 521010001151 TPR repeat; Region: TPR_11; pfam13414 521010001152 TPR motif; other site 521010001153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521010001154 TPR repeat; Region: TPR_11; pfam13414 521010001155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001156 binding surface 521010001157 TPR motif; other site 521010001158 TPR repeat; Region: TPR_11; pfam13414 521010001159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001160 binding surface 521010001161 TPR motif; other site 521010001162 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001163 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521010001164 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521010001165 RF-1 domain; Region: RF-1; pfam00472 521010001166 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 521010001167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521010001168 S-adenosylmethionine binding site [chemical binding]; other site 521010001169 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 521010001170 HD domain; Region: HD_4; pfam13328 521010001171 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 521010001172 synthetase active site [active] 521010001173 NTP binding site [chemical binding]; other site 521010001174 metal binding site [ion binding]; metal-binding site 521010001175 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 521010001176 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 521010001177 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521010001178 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 521010001179 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 521010001180 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521010001181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010001182 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010001183 Domain of unknown function DUF21; Region: DUF21; pfam01595 521010001184 FOG: CBS domain [General function prediction only]; Region: COG0517 521010001185 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521010001186 Transporter associated domain; Region: CorC_HlyC; pfam03471 521010001187 HflK protein; Region: hflK; TIGR01933 521010001188 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 521010001189 HflC protein; Region: hflC; TIGR01932 521010001190 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 521010001191 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521010001192 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 521010001193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521010001194 S-adenosylmethionine binding site [chemical binding]; other site 521010001195 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 521010001196 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 521010001197 active site 521010001198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001199 binding surface 521010001200 TPR motif; other site 521010001201 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001202 TPR repeat; Region: TPR_11; pfam13414 521010001203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001204 binding surface 521010001205 TPR repeat; Region: TPR_11; pfam13414 521010001206 TPR motif; other site 521010001207 TPR repeat; Region: TPR_11; pfam13414 521010001208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001209 binding surface 521010001210 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001211 TPR motif; other site 521010001212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001213 TPR motif; other site 521010001214 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001215 binding surface 521010001216 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 521010001217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010001218 Mg2+ binding site [ion binding]; other site 521010001219 G-X-G motif; other site 521010001220 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 521010001221 ATP binding site [chemical binding]; other site 521010001222 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 521010001223 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521010001224 translation elongation factor P; Region: efp; TIGR00038 521010001225 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521010001226 RNA binding site [nucleotide binding]; other site 521010001227 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521010001228 RNA binding site [nucleotide binding]; other site 521010001229 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 521010001230 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 521010001231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001232 dimer interface [polypeptide binding]; other site 521010001233 conserved gate region; other site 521010001234 putative PBP binding loops; other site 521010001235 ABC-ATPase subunit interface; other site 521010001236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 521010001237 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 521010001238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001239 dimer interface [polypeptide binding]; other site 521010001240 conserved gate region; other site 521010001241 putative PBP binding loops; other site 521010001242 ABC-ATPase subunit interface; other site 521010001243 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 521010001244 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 521010001245 Walker A/P-loop; other site 521010001246 ATP binding site [chemical binding]; other site 521010001247 Q-loop/lid; other site 521010001248 ABC transporter signature motif; other site 521010001249 Walker B; other site 521010001250 D-loop; other site 521010001251 H-loop/switch region; other site 521010001252 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 521010001253 ZIP Zinc transporter; Region: Zip; pfam02535 521010001254 alanyl-tRNA synthetase; Provisional; Region: PRK01584 521010001255 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 521010001256 motif 1; other site 521010001257 active site 521010001258 motif 2; other site 521010001259 motif 3; other site 521010001260 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521010001261 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 521010001262 Deoxyhypusine synthase; Region: DS; cl00826 521010001263 FliG C-terminal domain; Region: FliG_C; pfam01706 521010001264 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 521010001265 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 521010001266 putative active site [active] 521010001267 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521010001268 active site 521010001269 FMN binding site [chemical binding]; other site 521010001270 catalytic residues [active] 521010001271 substrate binding site [chemical binding]; other site 521010001272 seryl-tRNA synthetase; Region: serS; TIGR00414 521010001273 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521010001274 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 521010001275 dimer interface [polypeptide binding]; other site 521010001276 active site 521010001277 motif 1; other site 521010001278 motif 2; other site 521010001279 motif 3; other site 521010001280 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 521010001281 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521010001282 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010001283 Peptidase M16C associated; Region: M16C_assoc; pfam08367 521010001284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010001285 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 521010001286 transcription termination factor Rho; Region: rho; TIGR00767 521010001287 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 521010001288 RNA binding site [nucleotide binding]; other site 521010001289 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 521010001290 multimer interface [polypeptide binding]; other site 521010001291 Walker A motif; other site 521010001292 ATP binding site [chemical binding]; other site 521010001293 Walker B motif; other site 521010001294 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 521010001295 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 521010001296 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521010001297 IHF dimer interface [polypeptide binding]; other site 521010001298 IHF - DNA interface [nucleotide binding]; other site 521010001299 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 521010001300 GTP-binding protein YchF; Reviewed; Region: PRK09601 521010001301 YchF GTPase; Region: YchF; cd01900 521010001302 G1 box; other site 521010001303 GTP/Mg2+ binding site [chemical binding]; other site 521010001304 Switch I region; other site 521010001305 G2 box; other site 521010001306 Switch II region; other site 521010001307 G3 box; other site 521010001308 G4 box; other site 521010001309 G5 box; other site 521010001310 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521010001311 TPR repeat; Region: TPR_11; pfam13414 521010001312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001313 TPR motif; other site 521010001314 binding surface 521010001315 Uncharacterized conserved protein [Function unknown]; Region: COG3391 521010001316 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 521010001317 von Willebrand factor type A domain; Region: VWA_2; pfam13519 521010001318 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 521010001319 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 521010001320 putative active site [active] 521010001321 catalytic triad [active] 521010001322 putative dimer interface [polypeptide binding]; other site 521010001323 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 521010001324 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 521010001325 Substrate-binding site [chemical binding]; other site 521010001326 Substrate specificity [chemical binding]; other site 521010001327 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 521010001328 amphipathic channel; other site 521010001329 Asn-Pro-Ala signature motifs; other site 521010001330 glycerol kinase; Provisional; Region: glpK; PRK00047 521010001331 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 521010001332 N- and C-terminal domain interface [polypeptide binding]; other site 521010001333 active site 521010001334 MgATP binding site [chemical binding]; other site 521010001335 catalytic site [active] 521010001336 metal binding site [ion binding]; metal-binding site 521010001337 glycerol binding site [chemical binding]; other site 521010001338 homotetramer interface [polypeptide binding]; other site 521010001339 homodimer interface [polypeptide binding]; other site 521010001340 FBP binding site [chemical binding]; other site 521010001341 protein IIAGlc interface [polypeptide binding]; other site 521010001342 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 521010001343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 521010001344 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 521010001345 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 521010001346 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521010001347 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010001348 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521010001349 active site 521010001350 dimerization interface [polypeptide binding]; other site 521010001351 oligoendopeptidase F; Region: pepF; TIGR00181 521010001352 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 521010001353 active site 521010001354 Zn binding site [ion binding]; other site 521010001355 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 521010001356 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 521010001357 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521010001358 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 521010001359 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521010001360 HIGH motif; other site 521010001361 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521010001362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010001363 active site 521010001364 KMSKS motif; other site 521010001365 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521010001366 tRNA binding surface [nucleotide binding]; other site 521010001367 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 521010001368 Found in ATP-dependent protease La (LON); Region: LON; smart00464 521010001369 ATP-dependent protease La; Region: lon; TIGR00763 521010001370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001371 Walker A motif; other site 521010001372 ATP binding site [chemical binding]; other site 521010001373 Walker B motif; other site 521010001374 arginine finger; other site 521010001375 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 521010001376 DHH family; Region: DHH; pfam01368 521010001377 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521010001378 DHHA1 domain; Region: DHHA1; pfam02272 521010001379 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521010001380 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010001381 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 521010001382 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 521010001383 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 521010001384 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 521010001385 Bacitracin resistance protein BacA; Region: BacA; cl00858 521010001386 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 521010001387 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521010001388 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521010001389 catalytic residue [active] 521010001390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001391 TPR motif; other site 521010001392 binding surface 521010001393 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 521010001394 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521010001395 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010001396 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010001397 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010001398 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521010001399 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521010001400 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 521010001401 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 521010001402 nucleotide binding site [chemical binding]; other site 521010001403 putative NEF/HSP70 interaction site [polypeptide binding]; other site 521010001404 SBD interface [polypeptide binding]; other site 521010001405 Uncharacterized conserved protein [Function unknown]; Region: COG1315 521010001406 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521010001407 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010001408 P-loop; other site 521010001409 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 521010001410 Protein of unknown function, DUF258; Region: DUF258; pfam03193 521010001411 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521010001412 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 521010001413 FHIPEP family; Region: FHIPEP; pfam00771 521010001414 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 521010001415 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 521010001416 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 521010001417 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 521010001418 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 521010001419 flagellar biosynthesis protein FliZ; Provisional; Region: PRK13414 521010001420 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 521010001421 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 521010001422 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 521010001423 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK06654 521010001424 flagellar motor protein MotB; Validated; Region: motB; PRK06667 521010001425 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 521010001426 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521010001427 ligand binding site [chemical binding]; other site 521010001428 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 521010001429 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521010001430 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 521010001431 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 521010001432 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521010001433 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 521010001434 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521010001435 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 521010001436 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 521010001437 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 521010001438 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 521010001439 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521010001440 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521010001441 Walker A motif; other site 521010001442 ATP binding site [chemical binding]; other site 521010001443 Walker B motif; other site 521010001444 flagellar assembly protein H; Validated; Region: fliH; PRK06669 521010001445 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 521010001446 Flagellar assembly protein FliH; Region: FliH; pfam02108 521010001447 flagellar motor switch protein FliG; Region: fliG; TIGR00207 521010001448 FliG C-terminal domain; Region: FliG_C; pfam01706 521010001449 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 521010001450 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 521010001451 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 521010001452 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01482 521010001453 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 521010001454 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521010001455 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521010001456 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 521010001457 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521010001458 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 521010001459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001460 Walker A motif; other site 521010001461 ATP binding site [chemical binding]; other site 521010001462 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 521010001463 Walker B motif; other site 521010001464 arginine finger; other site 521010001465 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521010001466 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 521010001467 active site 521010001468 HslU subunit interaction site [polypeptide binding]; other site 521010001469 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 521010001470 DNA protecting protein DprA; Region: dprA; TIGR00732 521010001471 TPR repeat; Region: TPR_11; pfam13414 521010001472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001473 binding surface 521010001474 TPR motif; other site 521010001475 cell division protein FtsZ; Validated; Region: PRK09330 521010001476 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 521010001477 nucleotide binding site [chemical binding]; other site 521010001478 SulA interaction site; other site 521010001479 cell division protein FtsA; Region: ftsA; TIGR01174 521010001480 Cell division protein FtsA; Region: FtsA; smart00842 521010001481 Cell division protein FtsA; Region: FtsA; pfam14450 521010001482 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 521010001483 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 521010001484 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 521010001485 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 521010001486 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521010001487 Mg++ binding site [ion binding]; other site 521010001488 putative catalytic motif [active] 521010001489 putative substrate binding site [chemical binding]; other site 521010001490 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521010001491 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 521010001492 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010001493 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010001494 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 521010001495 MraW methylase family; Region: Methyltransf_5; pfam01795 521010001496 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 521010001497 ATP-NAD kinase; Region: NAD_kinase; pfam01513 521010001498 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 521010001499 putative CheA interaction surface; other site 521010001500 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 521010001501 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 521010001502 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521010001503 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521010001504 substrate binding pocket [chemical binding]; other site 521010001505 chain length determination region; other site 521010001506 substrate-Mg2+ binding site; other site 521010001507 catalytic residues [active] 521010001508 aspartate-rich region 1; other site 521010001509 active site lid residues [active] 521010001510 aspartate-rich region 2; other site 521010001511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521010001512 binding surface 521010001513 TPR repeat; Region: TPR_11; pfam13414 521010001514 TPR motif; other site 521010001515 Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079 521010001516 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010001517 TM-ABC transporter signature motif; other site 521010001518 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521010001519 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521010001520 Walker A/P-loop; other site 521010001521 ATP binding site [chemical binding]; other site 521010001522 Q-loop/lid; other site 521010001523 ABC transporter signature motif; other site 521010001524 Walker B; other site 521010001525 D-loop; other site 521010001526 H-loop/switch region; other site 521010001527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010001528 ABC transporter signature motif; other site 521010001529 Walker B; other site 521010001530 D-loop; other site 521010001531 H-loop/switch region; other site 521010001532 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001533 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521010001534 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 521010001535 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001536 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521010001537 metal ion-dependent adhesion site (MIDAS); other site 521010001538 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521010001539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001540 binding surface 521010001541 TPR motif; other site 521010001542 Phosphate acyltransferases; Region: PlsC; smart00563 521010001543 putative acyl-acceptor binding pocket; other site 521010001544 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010001545 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010001546 peptide binding site [polypeptide binding]; other site 521010001547 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010001548 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010001549 peptide binding site [polypeptide binding]; other site 521010001550 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 521010001551 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 521010001552 peptide binding site [polypeptide binding]; other site 521010001553 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 521010001554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001555 dimer interface [polypeptide binding]; other site 521010001556 conserved gate region; other site 521010001557 putative PBP binding loops; other site 521010001558 ABC-ATPase subunit interface; other site 521010001559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 521010001560 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521010001561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010001562 dimer interface [polypeptide binding]; other site 521010001563 conserved gate region; other site 521010001564 putative PBP binding loops; other site 521010001565 ABC-ATPase subunit interface; other site 521010001566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521010001567 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 521010001568 Walker A/P-loop; other site 521010001569 ATP binding site [chemical binding]; other site 521010001570 Q-loop/lid; other site 521010001571 ABC transporter signature motif; other site 521010001572 Walker B; other site 521010001573 D-loop; other site 521010001574 H-loop/switch region; other site 521010001575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521010001576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521010001577 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 521010001578 Walker A/P-loop; other site 521010001579 ATP binding site [chemical binding]; other site 521010001580 Q-loop/lid; other site 521010001581 ABC transporter signature motif; other site 521010001582 Walker B; other site 521010001583 D-loop; other site 521010001584 H-loop/switch region; other site 521010001585 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 521010001586 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 521010001587 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 521010001588 enolase; Provisional; Region: eno; PRK00077 521010001589 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521010001590 dimer interface [polypeptide binding]; other site 521010001591 metal binding site [ion binding]; metal-binding site 521010001592 substrate binding pocket [chemical binding]; other site 521010001593 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 521010001594 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521010001595 23S rRNA interface [nucleotide binding]; other site 521010001596 L3 interface [polypeptide binding]; other site 521010001597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521010001598 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 521010001599 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 521010001600 GatB domain; Region: GatB_Yqey; pfam02637 521010001601 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 521010001602 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 521010001603 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 521010001604 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521010001605 Part of AAA domain; Region: AAA_19; pfam13245 521010001606 Family description; Region: UvrD_C_2; pfam13538 521010001607 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 521010001608 Helix-turn-helix domain; Region: HTH_25; pfam13413 521010001609 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 521010001610 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 521010001611 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 521010001612 Domain of unknown function (DUF814); Region: DUF814; pfam05670 521010001613 pyruvate kinase; Region: pyruv_kin; TIGR01064 521010001614 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 521010001615 domain interfaces; other site 521010001616 active site 521010001617 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 521010001618 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 521010001619 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 521010001620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 521010001621 RNA methyltransferase, RsmE family; Region: TIGR00046 521010001622 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 521010001623 C-terminal peptidase (prc); Region: prc; TIGR00225 521010001624 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521010001625 protein binding site [polypeptide binding]; other site 521010001626 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521010001627 Catalytic dyad [active] 521010001628 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010001629 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 521010001630 P-loop; other site 521010001631 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010001632 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 521010001633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 521010001634 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 521010001635 active site 521010001636 dimer interfaces [polypeptide binding]; other site 521010001637 catalytic residues [active] 521010001638 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 521010001639 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521010001640 oligomer interface [polypeptide binding]; other site 521010001641 putative active site [active] 521010001642 metal binding site [ion binding]; metal-binding site 521010001643 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 521010001644 active site turn [active] 521010001645 phosphorylation site [posttranslational modification] 521010001646 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 521010001647 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521010001648 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521010001649 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521010001650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001651 Walker A motif; other site 521010001652 ATP binding site [chemical binding]; other site 521010001653 Walker B motif; other site 521010001654 arginine finger; other site 521010001655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521010001656 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521010001657 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521010001658 active site 521010001659 HIGH motif; other site 521010001660 dimer interface [polypeptide binding]; other site 521010001661 KMSKS motif; other site 521010001662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521010001663 RNA binding surface [nucleotide binding]; other site 521010001664 glycyl-tRNA synthetase; Provisional; Region: PRK04173 521010001665 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 521010001666 dimer interface [polypeptide binding]; other site 521010001667 motif 1; other site 521010001668 active site 521010001669 motif 2; other site 521010001670 motif 3; other site 521010001671 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 521010001672 anticodon binding site; other site 521010001673 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 521010001674 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521010001675 active site 521010001676 HIGH motif; other site 521010001677 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521010001678 active site 521010001679 KMSKS motif; other site 521010001680 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 521010001681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521010001682 Zn2+ binding site [ion binding]; other site 521010001683 Mg2+ binding site [ion binding]; other site 521010001684 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 521010001685 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 521010001686 S-adenosylmethionine synthetase; Region: metK; TIGR01034 521010001687 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521010001688 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521010001689 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521010001690 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 521010001691 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 521010001692 HIT family signature motif; other site 521010001693 catalytic residue [active] 521010001694 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 521010001695 MgtE intracellular N domain; Region: MgtE_N; pfam03448 521010001696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 521010001697 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 521010001698 Divalent cation transporter; Region: MgtE; pfam01769 521010001699 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 521010001700 Trehalase; Region: Trehalase; cl17346 521010001701 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001702 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521010001703 ligand binding site [chemical binding]; other site 521010001704 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001705 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521010001706 ligand binding site [chemical binding]; other site 521010001707 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521010001708 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521010001709 ligand binding site [chemical binding]; other site 521010001710 30S ribosomal protein S7; Validated; Region: PRK05302 521010001711 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521010001712 S17 interaction site [polypeptide binding]; other site 521010001713 S8 interaction site; other site 521010001714 16S rRNA interaction site [nucleotide binding]; other site 521010001715 streptomycin interaction site [chemical binding]; other site 521010001716 23S rRNA interaction site [nucleotide binding]; other site 521010001717 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521010001718 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 521010001719 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521010001720 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 521010001721 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521010001722 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521010001723 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 521010001724 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521010001725 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 521010001726 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521010001727 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 521010001728 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 521010001729 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521010001730 DNA binding site [nucleotide binding] 521010001731 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521010001732 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 521010001733 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 521010001734 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521010001735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521010001736 RPB10 interaction site [polypeptide binding]; other site 521010001737 RPB1 interaction site [polypeptide binding]; other site 521010001738 RPB11 interaction site [polypeptide binding]; other site 521010001739 RPB3 interaction site [polypeptide binding]; other site 521010001740 RPB12 interaction site [polypeptide binding]; other site 521010001741 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521010001742 core dimer interface [polypeptide binding]; other site 521010001743 peripheral dimer interface [polypeptide binding]; other site 521010001744 L10 interface [polypeptide binding]; other site 521010001745 L11 interface [polypeptide binding]; other site 521010001746 putative EF-Tu interaction site [polypeptide binding]; other site 521010001747 putative EF-G interaction site [polypeptide binding]; other site 521010001748 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521010001749 23S rRNA interface [nucleotide binding]; other site 521010001750 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521010001751 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521010001752 mRNA/rRNA interface [nucleotide binding]; other site 521010001753 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521010001754 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521010001755 23S rRNA interface [nucleotide binding]; other site 521010001756 L7/L12 interface [polypeptide binding]; other site 521010001757 putative thiostrepton binding site; other site 521010001758 L25 interface [polypeptide binding]; other site 521010001759 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 521010001760 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521010001761 putative homodimer interface [polypeptide binding]; other site 521010001762 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 521010001763 heterodimer interface [polypeptide binding]; other site 521010001764 homodimer interface [polypeptide binding]; other site 521010001765 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 521010001766 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 521010001767 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 521010001768 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 521010001769 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 521010001770 prolyl-tRNA synthetase; Provisional; Region: PRK08661 521010001771 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 521010001772 dimer interface [polypeptide binding]; other site 521010001773 motif 1; other site 521010001774 active site 521010001775 motif 2; other site 521010001776 motif 3; other site 521010001777 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 521010001778 anticodon binding site; other site 521010001779 zinc-binding site [ion binding]; other site 521010001780 Predicted secreted protein [Function unknown]; Region: COG5497 521010001781 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010001782 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010001783 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 521010001784 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521010001785 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521010001786 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 521010001787 active site 521010001788 phosphorylation site [posttranslational modification] 521010001789 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521010001790 active site 521010001791 P-loop; other site 521010001792 phosphorylation site [posttranslational modification] 521010001793 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 521010001794 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 521010001795 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 521010001796 active site 521010001797 substrate binding site [chemical binding]; other site 521010001798 Mg2+ binding site [ion binding]; other site 521010001799 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 521010001800 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 521010001801 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 521010001802 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 521010001803 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 521010001804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 521010001805 active site 521010001806 phosphorylation site [posttranslational modification] 521010001807 intermolecular recognition site; other site 521010001808 CheB methylesterase; Region: CheB_methylest; pfam01339 521010001809 pheromone shutdown-related protein TraB; Region: traB; TIGR00261 521010001810 adenylate kinase; Provisional; Region: PRK14526 521010001811 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521010001812 AMP-binding site [chemical binding]; other site 521010001813 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521010001814 Response regulator receiver domain; Region: Response_reg; pfam00072 521010001815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010001816 active site 521010001817 phosphorylation site [posttranslational modification] 521010001818 intermolecular recognition site; other site 521010001819 dimerization interface [polypeptide binding]; other site 521010001820 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 521010001821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 521010001822 metal binding site [ion binding]; metal-binding site 521010001823 active site 521010001824 I-site; other site 521010001825 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521010001826 substrate binding pocket [chemical binding]; other site 521010001827 membrane-bound complex binding site; other site 521010001828 hinge residues; other site 521010001829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521010001830 dimer interface [polypeptide binding]; other site 521010001831 phosphorylation site [posttranslational modification] 521010001832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010001833 ATP binding site [chemical binding]; other site 521010001834 Mg2+ binding site [ion binding]; other site 521010001835 G-X-G motif; other site 521010001836 Response regulator receiver domain; Region: Response_reg; pfam00072 521010001837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010001838 active site 521010001839 phosphorylation site [posttranslational modification] 521010001840 intermolecular recognition site; other site 521010001841 dimerization interface [polypeptide binding]; other site 521010001842 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521010001843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010001844 active site 521010001845 motif I; other site 521010001846 motif II; other site 521010001847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 521010001848 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 521010001849 active site 521010001850 DNA binding site [nucleotide binding] 521010001851 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 521010001852 Predicted methyltransferases [General function prediction only]; Region: COG0313 521010001853 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 521010001854 putative SAM binding site [chemical binding]; other site 521010001855 putative homodimer interface [polypeptide binding]; other site 521010001856 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 521010001857 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 521010001858 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010001859 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010001860 P-loop; other site 521010001861 Magnesium ion binding site [ion binding]; other site 521010001862 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010001863 Magnesium ion binding site [ion binding]; other site 521010001864 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521010001865 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521010001866 ParB-like nuclease domain; Region: ParB; smart00470 521010001867 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 521010001868 non-specific DNA binding site [nucleotide binding]; other site 521010001869 salt bridge; other site 521010001870 sequence-specific DNA binding site [nucleotide binding]; other site 521010001871 DNA gyrase, A subunit; Region: gyrA; TIGR01063 521010001872 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 521010001873 CAP-like domain; other site 521010001874 active site 521010001875 primary dimer interface [polypeptide binding]; other site 521010001876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001878 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001879 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001880 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521010001881 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 521010001882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010001883 ATP binding site [chemical binding]; other site 521010001884 Mg2+ binding site [ion binding]; other site 521010001885 G-X-G motif; other site 521010001886 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521010001887 anchoring element; other site 521010001888 dimer interface [polypeptide binding]; other site 521010001889 ATP binding site [chemical binding]; other site 521010001890 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 521010001891 active site 521010001892 putative metal-binding site [ion binding]; other site 521010001893 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521010001894 DnaA N-terminal domain; Region: DnaA_N; pfam11638 521010001895 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 521010001896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001897 Walker A motif; other site 521010001898 ATP binding site [chemical binding]; other site 521010001899 Walker B motif; other site 521010001900 arginine finger; other site 521010001901 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521010001902 DnaA box-binding interface [nucleotide binding]; other site 521010001903 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 521010001904 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521010001905 putative DNA binding surface [nucleotide binding]; other site 521010001906 dimer interface [polypeptide binding]; other site 521010001907 beta-clamp/clamp loader binding surface; other site 521010001908 beta-clamp/translesion DNA polymerase binding surface; other site 521010001909 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 521010001910 Ribonuclease P; Region: Ribonuclease_P; cl00457 521010001911 membrane protein insertase; Provisional; Region: PRK01318 521010001912 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 521010001913 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 521010001914 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521010001915 G-X-X-G motif; other site 521010001916 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 521010001917 RxxxH motif; other site 521010001918 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521010001919 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 521010001920 putative NAD(P) binding site [chemical binding]; other site 521010001921 active site 521010001922 putative substrate binding site [chemical binding]; other site 521010001923 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 521010001924 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 521010001925 active site 521010001926 intersubunit interface [polypeptide binding]; other site 521010001927 zinc binding site [ion binding]; other site 521010001928 Na+ binding site [ion binding]; other site 521010001929 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521010001930 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521010001931 dimer interface [polypeptide binding]; other site 521010001932 anticodon binding site; other site 521010001933 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521010001934 homodimer interface [polypeptide binding]; other site 521010001935 motif 1; other site 521010001936 active site 521010001937 motif 2; other site 521010001938 GAD domain; Region: GAD; pfam02938 521010001939 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521010001940 active site 521010001941 motif 3; other site 521010001942 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 521010001943 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 521010001944 Sexual stage antigen s48/45 domain; Region: s48_45; smart00970 521010001945 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521010001946 active site 521010001947 phosphorylation site [posttranslational modification] 521010001948 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 521010001949 active site 521010001950 regulatory protein interface [polypeptide binding]; other site 521010001951 regulatory phosphorylation site [posttranslational modification]; other site 521010001952 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 521010001953 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 521010001954 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 521010001955 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 521010001956 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 521010001957 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 521010001958 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 521010001959 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 521010001960 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521010001961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521010001962 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 521010001963 putative ADP-binding pocket [chemical binding]; other site 521010001964 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 521010001965 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521010001966 GIY-YIG motif/motif A; other site 521010001967 active site 521010001968 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 521010001969 catalytic site [active] 521010001970 putative DNA binding site [nucleotide binding]; other site 521010001971 metal binding site [ion binding]; metal-binding site 521010001972 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521010001973 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521010001974 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 521010001975 Interdomain contacts; other site 521010001976 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521010001977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010001978 binding surface 521010001979 TPR motif; other site 521010001980 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 521010001981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010001982 Walker A motif; other site 521010001983 ATP binding site [chemical binding]; other site 521010001984 Walker B motif; other site 521010001985 DNA polymerase III subunit delta'; Validated; Region: PRK08485 521010001986 arginine finger; other site 521010001987 hypothetical protein; Provisional; Region: PRK14629 521010001988 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 521010001989 active site 521010001990 multimer interface [polypeptide binding]; other site 521010001991 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 521010001992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 521010001993 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 521010001994 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 521010001995 Walker A/P-loop; other site 521010001996 ATP binding site [chemical binding]; other site 521010001997 Q-loop/lid; other site 521010001998 ABC transporter signature motif; other site 521010001999 Walker B; other site 521010002000 D-loop; other site 521010002001 H-loop/switch region; other site 521010002002 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 521010002003 uncharacterized protein, YfiH family; Region: TIGR00726 521010002004 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521010002005 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 521010002006 signal peptidase II; Provisional; Region: lspA; PRK01574 521010002007 lipoprotein signal peptidase; Provisional; Region: PRK14787 521010002008 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 521010002009 active site 521010002010 metal binding site [ion binding]; metal-binding site 521010002011 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521010002012 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521010002013 hinge; other site 521010002014 active site 521010002015 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 521010002016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521010002017 elongation factor Tu; Reviewed; Region: PRK00049 521010002018 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521010002019 G1 box; other site 521010002020 GEF interaction site [polypeptide binding]; other site 521010002021 GTP/Mg2+ binding site [chemical binding]; other site 521010002022 Switch I region; other site 521010002023 G2 box; other site 521010002024 G3 box; other site 521010002025 Switch II region; other site 521010002026 G4 box; other site 521010002027 G5 box; other site 521010002028 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521010002029 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521010002030 Antibiotic Binding Site [chemical binding]; other site 521010002031 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 521010002032 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 521010002033 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 521010002034 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 521010002035 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521010002036 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521010002037 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521010002038 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 521010002039 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521010002040 putative translocon binding site; other site 521010002041 protein-rRNA interface [nucleotide binding]; other site 521010002042 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521010002043 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521010002044 G-X-X-G motif; other site 521010002045 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521010002046 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521010002047 23S rRNA interface [nucleotide binding]; other site 521010002048 5S rRNA interface [nucleotide binding]; other site 521010002049 putative antibiotic binding site [chemical binding]; other site 521010002050 L25 interface [polypeptide binding]; other site 521010002051 L27 interface [polypeptide binding]; other site 521010002052 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521010002053 23S rRNA interface [nucleotide binding]; other site 521010002054 putative translocon interaction site; other site 521010002055 signal recognition particle (SRP54) interaction site; other site 521010002056 L23 interface [polypeptide binding]; other site 521010002057 trigger factor interaction site; other site 521010002058 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 521010002059 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 521010002060 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521010002061 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 521010002062 RNA binding site [nucleotide binding]; other site 521010002063 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521010002064 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521010002065 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521010002066 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 521010002067 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 521010002068 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521010002069 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521010002070 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521010002071 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521010002072 5S rRNA interface [nucleotide binding]; other site 521010002073 23S rRNA interface [nucleotide binding]; other site 521010002074 L5 interface [polypeptide binding]; other site 521010002075 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 521010002076 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521010002077 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521010002078 ribosomal protein L30, bacterial/organelle; Region: rpmD_bact; TIGR01308 521010002079 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 521010002080 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521010002081 SecY translocase; Region: SecY; pfam00344 521010002082 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 521010002083 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 521010002084 30S ribosomal protein S13; Region: bact_S13; TIGR03631 521010002085 30S ribosomal protein S11; Validated; Region: PRK05309 521010002086 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521010002087 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521010002088 alphaNTD - beta interaction site [polypeptide binding]; other site 521010002089 alphaNTD homodimer interface [polypeptide binding]; other site 521010002090 alphaNTD - beta' interaction site [polypeptide binding]; other site 521010002091 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521010002092 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 521010002093 phosphodiesterase; Provisional; Region: PRK12704 521010002094 KH domain; Region: KH_1; pfam00013 521010002095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521010002096 Zn2+ binding site [ion binding]; other site 521010002097 Mg2+ binding site [ion binding]; other site 521010002098 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 521010002099 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521010002100 putative active site [active] 521010002101 metal binding site [ion binding]; metal-binding site 521010002102 homodimer binding site [polypeptide binding]; other site 521010002103 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 521010002104 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 521010002105 Spore germination protein [General function prediction only]; Region: COG5401 521010002106 Sporulation and spore germination; Region: Germane; smart00909 521010002107 GTP-binding protein Der; Reviewed; Region: PRK00093 521010002108 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 521010002109 G1 box; other site 521010002110 GTP/Mg2+ binding site [chemical binding]; other site 521010002111 Switch I region; other site 521010002112 G2 box; other site 521010002113 Switch II region; other site 521010002114 G3 box; other site 521010002115 G4 box; other site 521010002116 G5 box; other site 521010002117 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521010002118 G1 box; other site 521010002119 GTP/Mg2+ binding site [chemical binding]; other site 521010002120 Switch I region; other site 521010002121 G2 box; other site 521010002122 G3 box; other site 521010002123 Switch II region; other site 521010002124 G4 box; other site 521010002125 G5 box; other site 521010002126 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 521010002127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010002128 motif II; other site 521010002129 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521010002130 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010002131 V-type ATP synthase subunit I; Validated; Region: PRK05771 521010002132 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010002133 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 521010002134 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521010002135 dimer interface [polypeptide binding]; other site 521010002136 motif 1; other site 521010002137 active site 521010002138 motif 2; other site 521010002139 motif 3; other site 521010002140 phenylalanyl-tRNA synthetase, beta subunit; Region: pheT_arch; TIGR00471 521010002141 tRNA synthetase B5 domain; Region: B5; pfam03484 521010002142 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521010002143 dimer interface [polypeptide binding]; other site 521010002144 motif 1; other site 521010002145 motif 3; other site 521010002146 motif 2; other site 521010002147 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521010002148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521010002149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521010002150 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 521010002151 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 521010002152 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521010002153 chaperone protein DnaJ; Provisional; Region: PRK14285 521010002154 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521010002155 HSP70 interaction site [polypeptide binding]; other site 521010002156 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521010002157 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521010002158 dimer interface [polypeptide binding]; other site 521010002159 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521010002160 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 521010002161 nucleotide binding site [chemical binding]; other site 521010002162 NEF interaction site [polypeptide binding]; other site 521010002163 SBD interface [polypeptide binding]; other site 521010002164 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 521010002165 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521010002166 dimer interface [polypeptide binding]; other site 521010002167 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521010002168 NAD synthetase; Provisional; Region: PRK13981 521010002169 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 521010002170 active site 521010002171 catalytic triad [active] 521010002172 dimer interface [polypeptide binding]; other site 521010002173 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521010002174 homodimer interface [polypeptide binding]; other site 521010002175 NAD binding pocket [chemical binding]; other site 521010002176 ATP binding pocket [chemical binding]; other site 521010002177 Mg binding site [ion binding]; other site 521010002178 active-site loop [active] 521010002179 pantothenate kinase; Reviewed; Region: PRK13326 521010002180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521010002181 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521010002182 active site 521010002183 catalytic tetrad [active] 521010002184 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 521010002185 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 521010002186 putative hydrolase; Provisional; Region: PRK02113 521010002187 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 521010002188 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 521010002189 active site 521010002190 putative catalytic site [active] 521010002191 phosphate binding site A [ion binding]; other site 521010002192 DNA binding site [nucleotide binding] 521010002193 metal binding site A [ion binding]; metal-binding site 521010002194 putative AP binding site [nucleotide binding]; other site 521010002195 putative metal binding site B [ion binding]; other site 521010002196 phosphate binding site B [ion binding]; other site 521010002197 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521010002198 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521010002199 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010002200 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521010002201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002202 binding surface 521010002203 TPR motif; other site 521010002204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002205 binding surface 521010002206 TPR repeat; Region: TPR_11; pfam13414 521010002207 TPR motif; other site 521010002208 TPR repeat; Region: TPR_11; pfam13414 521010002209 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 521010002210 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 521010002211 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 521010002212 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 521010002213 translation elongation factor EF-G; Region: EF-G; TIGR00484 521010002214 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521010002215 G1 box; other site 521010002216 putative GEF interaction site [polypeptide binding]; other site 521010002217 GTP/Mg2+ binding site [chemical binding]; other site 521010002218 Switch I region; other site 521010002219 G2 box; other site 521010002220 G3 box; other site 521010002221 Switch II region; other site 521010002222 G4 box; other site 521010002223 G5 box; other site 521010002224 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 521010002225 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521010002226 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 521010002227 KTSC domain; Region: KTSC; pfam13619 521010002228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002229 binding surface 521010002230 TPR motif; other site 521010002231 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 521010002232 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521010002233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010002234 active site 521010002235 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 521010002236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521010002237 nucleotide binding site [chemical binding]; other site 521010002238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 521010002239 Sporulation related domain; Region: SPOR; pfam05036 521010002240 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521010002241 CoA-binding site [chemical binding]; other site 521010002242 ATP-binding [chemical binding]; other site 521010002243 DNA polymerase I; Region: pola; TIGR00593 521010002244 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521010002245 active site 521010002246 metal binding site 1 [ion binding]; metal-binding site 521010002247 putative 5' ssDNA interaction site; other site 521010002248 metal binding site 3; metal-binding site 521010002249 metal binding site 2 [ion binding]; metal-binding site 521010002250 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521010002251 putative DNA binding site [nucleotide binding]; other site 521010002252 putative metal binding site [ion binding]; other site 521010002253 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 521010002254 active site 521010002255 catalytic site [active] 521010002256 substrate binding site [chemical binding]; other site 521010002257 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521010002258 active site 521010002259 DNA binding site [nucleotide binding] 521010002260 catalytic site [active] 521010002261 Flagellar protein FliS; Region: FliS; cl00654 521010002262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002263 Response regulator receiver domain; Region: Response_reg; pfam00072 521010002264 active site 521010002265 phosphorylation site [posttranslational modification] 521010002266 intermolecular recognition site; other site 521010002267 dimerization interface [polypeptide binding]; other site 521010002268 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 521010002269 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521010002270 nucleotide binding pocket [chemical binding]; other site 521010002271 K-X-D-G motif; other site 521010002272 catalytic site [active] 521010002273 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521010002274 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521010002275 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521010002276 Dimer interface [polypeptide binding]; other site 521010002277 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 521010002278 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 521010002279 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 521010002280 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521010002281 dimerization domain swap beta strand [polypeptide binding]; other site 521010002282 regulatory protein interface [polypeptide binding]; other site 521010002283 active site 521010002284 regulatory phosphorylation site [posttranslational modification]; other site 521010002285 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 521010002286 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 521010002287 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521010002288 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521010002289 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 521010002290 HPr interaction site; other site 521010002291 glycerol kinase (GK) interaction site [polypeptide binding]; other site 521010002292 active site 521010002293 phosphorylation site [posttranslational modification] 521010002294 heat shock protein 90; Provisional; Region: PRK05218 521010002295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002296 ATP binding site [chemical binding]; other site 521010002297 Mg2+ binding site [ion binding]; other site 521010002298 G-X-G motif; other site 521010002299 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521010002300 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 521010002301 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 521010002302 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010002303 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010002304 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 521010002305 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 521010002306 putative CheA interaction surface; other site 521010002307 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 521010002308 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 521010002309 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521010002310 putative binding surface; other site 521010002311 active site 521010002312 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 521010002313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002314 ATP binding site [chemical binding]; other site 521010002315 Mg2+ binding site [ion binding]; other site 521010002316 G-X-G motif; other site 521010002317 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 521010002318 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 521010002319 CheB methylesterase; Region: CheB_methylest; pfam01339 521010002320 chromosome segregation protein; Provisional; Region: PRK01156 521010002321 Response regulator receiver domain; Region: Response_reg; pfam00072 521010002322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002323 active site 521010002324 phosphorylation site [posttranslational modification] 521010002325 intermolecular recognition site; other site 521010002326 dimerization interface [polypeptide binding]; other site 521010002327 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 521010002328 nucleotide binding site [chemical binding]; other site 521010002329 homodimeric interface [polypeptide binding]; other site 521010002330 uridine monophosphate binding site [chemical binding]; other site 521010002331 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521010002332 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521010002333 active site 521010002334 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521010002335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010002336 Walker A/P-loop; other site 521010002337 ATP binding site [chemical binding]; other site 521010002338 Q-loop/lid; other site 521010002339 ABC transporter signature motif; other site 521010002340 Walker B; other site 521010002341 D-loop; other site 521010002342 H-loop/switch region; other site 521010002343 CTP synthase; Region: PyrG; TIGR00337 521010002344 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521010002345 Catalytic site [active] 521010002346 active site 521010002347 UTP binding site [chemical binding]; other site 521010002348 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521010002349 active site 521010002350 putative oxyanion hole; other site 521010002351 catalytic triad [active] 521010002352 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002353 putative CheW interface [polypeptide binding]; other site 521010002354 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 521010002355 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 521010002356 active site 521010002357 PHP Thumb interface [polypeptide binding]; other site 521010002358 metal binding site [ion binding]; metal-binding site 521010002359 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521010002360 generic binding surface I; other site 521010002361 generic binding surface II; other site 521010002362 YGGT family; Region: YGGT; cl00508 521010002363 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 521010002364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010002365 ATP binding site [chemical binding]; other site 521010002366 putative Mg++ binding site [ion binding]; other site 521010002367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010002368 nucleotide binding region [chemical binding]; other site 521010002369 ATP-binding site [chemical binding]; other site 521010002370 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 521010002371 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 521010002372 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521010002373 putative efflux protein, MATE family; Region: matE; TIGR00797 521010002374 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521010002375 MatE; Region: MatE; pfam01554 521010002376 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 521010002377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010002378 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010002379 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 521010002380 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 521010002381 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521010002382 active site 521010002383 HIGH motif; other site 521010002384 KMSKS motif; other site 521010002385 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521010002386 tRNA binding surface [nucleotide binding]; other site 521010002387 anticodon binding site; other site 521010002388 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 521010002389 putative tRNA-binding site [nucleotide binding]; other site 521010002390 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 521010002391 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 521010002392 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 521010002393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521010002394 S-adenosylmethionine binding site [chemical binding]; other site 521010002395 Competence protein; Region: Competence; cl00471 521010002396 CAAX protease self-immunity; Region: Abi; pfam02517 521010002397 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 521010002398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521010002399 acyl-activating enzyme (AAE) consensus motif; other site 521010002400 AMP binding site [chemical binding]; other site 521010002401 active site 521010002402 CoA binding site [chemical binding]; other site 521010002403 arginyl-tRNA synthetase; Region: argS; TIGR00456 521010002404 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521010002405 active site 521010002406 HIGH motif; other site 521010002407 KMSK motif region; other site 521010002408 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521010002409 tRNA binding surface [nucleotide binding]; other site 521010002410 anticodon binding site; other site 521010002411 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521010002412 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002413 dimer interface [polypeptide binding]; other site 521010002414 putative CheW interface [polypeptide binding]; other site 521010002415 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521010002416 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002417 putative CheW interface [polypeptide binding]; other site 521010002418 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 521010002419 FAD binding domain; Region: FAD_binding_4; pfam01565 521010002420 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521010002421 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010002422 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521010002423 KMSKS motif; other site 521010002424 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521010002425 IPT/TIG domain; Region: TIG; pfam01833 521010002426 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 521010002427 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 521010002428 dimer interface [polypeptide binding]; other site 521010002429 active site 521010002430 glycine-pyridoxal phosphate binding site [chemical binding]; other site 521010002431 folate binding site [chemical binding]; other site 521010002432 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521010002433 HSP70 interaction site [polypeptide binding]; other site 521010002434 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 521010002435 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 521010002436 L-lactate permease; Region: Lactate_perm; cl00701 521010002437 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 521010002438 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 521010002439 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 521010002440 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13494 521010002441 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 521010002442 Part of AAA domain; Region: AAA_19; pfam13245 521010002443 Family description; Region: UvrD_C_2; pfam13538 521010002444 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 521010002445 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 521010002446 metal binding site [ion binding]; metal-binding site 521010002447 dimer interface [polypeptide binding]; other site 521010002448 trigger factor; Provisional; Region: tig; PRK01490 521010002449 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 521010002450 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 521010002451 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521010002452 oligomer interface [polypeptide binding]; other site 521010002453 active site residues [active] 521010002454 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521010002455 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 521010002456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002457 Walker A motif; other site 521010002458 ATP binding site [chemical binding]; other site 521010002459 Walker B motif; other site 521010002460 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521010002461 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 521010002462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002463 Walker A motif; other site 521010002464 ATP binding site [chemical binding]; other site 521010002465 Walker B motif; other site 521010002466 arginine finger; other site 521010002467 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 521010002468 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521010002469 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521010002470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521010002471 RNA binding surface [nucleotide binding]; other site 521010002472 Predicted acetyltransferase [General function prediction only]; Region: COG2388 521010002473 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521010002474 Cation efflux family; Region: Cation_efflux; pfam01545 521010002475 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521010002476 active site 521010002477 catalytic motif [active] 521010002478 Zn binding site [ion binding]; other site 521010002479 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 521010002480 DHH family; Region: DHH; pfam01368 521010002481 DHHA1 domain; Region: DHHA1; pfam02272 521010002482 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 521010002483 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 521010002484 DJ-1 family protein; Region: not_thiJ; TIGR01383 521010002485 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 521010002486 conserved cys residue [active] 521010002487 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 521010002488 propionate/acetate kinase; Provisional; Region: PRK12379 521010002489 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 521010002490 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 521010002491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010002492 ATP binding site [chemical binding]; other site 521010002493 putative Mg++ binding site [ion binding]; other site 521010002494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010002495 nucleotide binding region [chemical binding]; other site 521010002496 ATP-binding site [chemical binding]; other site 521010002497 TRCF domain; Region: TRCF; pfam03461 521010002498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002499 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 521010002500 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002501 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002503 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002504 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521010002505 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521010002506 active site 521010002507 metal binding site [ion binding]; metal-binding site 521010002508 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 521010002509 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 521010002510 putative active site [active] 521010002511 putative metal binding site [ion binding]; other site 521010002512 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 521010002513 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521010002514 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521010002515 metal binding site [ion binding]; metal-binding site 521010002516 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 521010002517 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521010002518 active site 521010002519 phosphorylation site [posttranslational modification] 521010002520 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521010002521 active site 521010002522 P-loop; other site 521010002523 phosphorylation site [posttranslational modification] 521010002524 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 521010002525 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521010002526 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521010002527 putative substrate binding site [chemical binding]; other site 521010002528 putative ATP binding site [chemical binding]; other site 521010002529 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 521010002530 AAA domain; Region: AAA_30; pfam13604 521010002531 Family description; Region: UvrD_C_2; pfam13538 521010002532 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 521010002533 Part of AAA domain; Region: AAA_19; pfam13245 521010002534 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521010002535 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 521010002536 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 521010002537 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 521010002538 active site 521010002539 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 521010002540 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 521010002541 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 521010002542 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521010002543 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 521010002544 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521010002545 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 521010002546 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 521010002547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521010002548 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521010002549 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 521010002550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002551 dimer interface [polypeptide binding]; other site 521010002552 conserved gate region; other site 521010002553 putative PBP binding loops; other site 521010002554 ABC-ATPase subunit interface; other site 521010002555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002556 dimer interface [polypeptide binding]; other site 521010002557 conserved gate region; other site 521010002558 putative PBP binding loops; other site 521010002559 ABC-ATPase subunit interface; other site 521010002560 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521010002561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010002562 Walker A/P-loop; other site 521010002563 ATP binding site [chemical binding]; other site 521010002564 Q-loop/lid; other site 521010002565 ABC transporter signature motif; other site 521010002566 Walker B; other site 521010002567 D-loop; other site 521010002568 H-loop/switch region; other site 521010002569 TOBE domain; Region: TOBE_2; pfam08402 521010002570 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 521010002571 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 521010002572 GTP/Mg2+ binding site [chemical binding]; other site 521010002573 G4 box; other site 521010002574 G5 box; other site 521010002575 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 521010002576 G1 box; other site 521010002577 Switch I region; other site 521010002578 G2 box; other site 521010002579 G3 box; other site 521010002580 Switch II region; other site 521010002581 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 521010002582 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 521010002583 putative active site cavity [active] 521010002584 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 521010002585 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 521010002586 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521010002587 active site turn [active] 521010002588 phosphorylation site [posttranslational modification] 521010002589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521010002590 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521010002591 metal binding site 2 [ion binding]; metal-binding site 521010002592 putative DNA binding helix; other site 521010002593 metal binding site 1 [ion binding]; metal-binding site 521010002594 structural Zn2+ binding site [ion binding]; other site 521010002595 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521010002596 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521010002597 ring oligomerisation interface [polypeptide binding]; other site 521010002598 ATP/Mg binding site [chemical binding]; other site 521010002599 stacking interactions; other site 521010002600 hinge regions; other site 521010002601 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 521010002602 protein-export membrane protein SecD; Region: secD; TIGR01129 521010002603 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 521010002604 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 521010002605 Protein export membrane protein; Region: SecD_SecF; pfam02355 521010002606 chaperone protein DnaJ; Provisional; Region: PRK14299 521010002607 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521010002608 HSP70 interaction site [polypeptide binding]; other site 521010002609 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521010002610 dimer interface [polypeptide binding]; other site 521010002611 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 521010002612 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 521010002613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521010002614 active site 521010002615 dimer interface [polypeptide binding]; other site 521010002616 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521010002617 catalytic core [active] 521010002618 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521010002619 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 521010002620 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 521010002621 active site 521010002622 HIGH motif; other site 521010002623 KMSKS motif; other site 521010002624 GTPase Era; Reviewed; Region: era; PRK00089 521010002625 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 521010002626 G1 box; other site 521010002627 GTP/Mg2+ binding site [chemical binding]; other site 521010002628 Switch I region; other site 521010002629 G2 box; other site 521010002630 Switch II region; other site 521010002631 G3 box; other site 521010002632 G4 box; other site 521010002633 G5 box; other site 521010002634 KH domain; Region: KH_2; pfam07650 521010002635 Double zinc ribbon; Region: DZR; pfam12773 521010002636 Uncharacterized conserved protein [Function unknown]; Region: COG1430 521010002637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521010002638 active site 521010002639 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521010002640 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521010002641 active site 521010002642 metal binding site [ion binding]; metal-binding site 521010002643 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 521010002644 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 521010002645 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 521010002646 putative binding surface; other site 521010002647 active site 521010002648 P2 response regulator binding domain; Region: P2; pfam07194 521010002649 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 521010002650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002651 ATP binding site [chemical binding]; other site 521010002652 Mg2+ binding site [ion binding]; other site 521010002653 G-X-G motif; other site 521010002654 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 521010002655 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 521010002656 putative CheA interaction surface; other site 521010002657 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 521010002658 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 521010002659 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 521010002660 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 521010002661 Response regulator receiver domain; Region: Response_reg; pfam00072 521010002662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002663 active site 521010002664 phosphorylation site [posttranslational modification] 521010002665 intermolecular recognition site; other site 521010002666 dimerization interface [polypeptide binding]; other site 521010002667 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521010002668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521010002669 motif II; other site 521010002670 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 521010002671 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521010002672 Walker A/P-loop; other site 521010002673 ATP binding site [chemical binding]; other site 521010002674 Q-loop/lid; other site 521010002675 ABC transporter signature motif; other site 521010002676 Walker B; other site 521010002677 D-loop; other site 521010002678 H-loop/switch region; other site 521010002679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010002680 Walker A/P-loop; other site 521010002681 ATP binding site [chemical binding]; other site 521010002682 Q-loop/lid; other site 521010002683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010002684 ABC transporter signature motif; other site 521010002685 Walker B; other site 521010002686 D-loop; other site 521010002687 H-loop/switch region; other site 521010002688 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521010002689 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010002690 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010002691 TM-ABC transporter signature motif; other site 521010002692 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521010002693 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521010002694 TM-ABC transporter signature motif; other site 521010002695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002696 dimer interface [polypeptide binding]; other site 521010002697 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 521010002698 putative CheW interface [polypeptide binding]; other site 521010002699 HAMP domain; Region: HAMP; pfam00672 521010002700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 521010002701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 521010002702 dimer interface [polypeptide binding]; other site 521010002703 putative CheW interface [polypeptide binding]; other site 521010002704 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 521010002705 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521010002706 Ligand Binding Site [chemical binding]; other site 521010002707 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 521010002708 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 521010002709 dimer interface [polypeptide binding]; other site 521010002710 active site 521010002711 isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151 521010002712 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 521010002713 homotetramer interface [polypeptide binding]; other site 521010002714 FMN binding site [chemical binding]; other site 521010002715 homodimer contacts [polypeptide binding]; other site 521010002716 putative active site [active] 521010002717 putative substrate binding site [chemical binding]; other site 521010002718 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 521010002719 homodimer interface [polypeptide binding]; other site 521010002720 catalytic residues [active] 521010002721 NAD binding site [chemical binding]; other site 521010002722 substrate binding pocket [chemical binding]; other site 521010002723 flexible flap; other site 521010002724 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 521010002725 diphosphomevalonate decarboxylase; Region: PLN02407 521010002726 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 521010002727 mevalonate kinase; Region: mevalon_kin; TIGR00549 521010002728 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 521010002729 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 521010002730 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 521010002731 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521010002732 dimerization interface [polypeptide binding]; other site 521010002733 DPS ferroxidase diiron center [ion binding]; other site 521010002734 ion pore; other site 521010002735 elongation factor G; Reviewed; Region: PRK13351 521010002736 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521010002737 G1 box; other site 521010002738 putative GEF interaction site [polypeptide binding]; other site 521010002739 GTP/Mg2+ binding site [chemical binding]; other site 521010002740 Switch I region; other site 521010002741 G2 box; other site 521010002742 G3 box; other site 521010002743 Switch II region; other site 521010002744 G4 box; other site 521010002745 G5 box; other site 521010002746 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521010002747 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 521010002748 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521010002749 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521010002750 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521010002751 signal recognition particle protein; Provisional; Region: PRK10867 521010002752 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 521010002753 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521010002754 P loop; other site 521010002755 GTP binding site [chemical binding]; other site 521010002756 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521010002757 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 521010002758 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 521010002759 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 521010002760 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 521010002761 RimM N-terminal domain; Region: RimM; pfam01782 521010002762 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 521010002763 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 521010002764 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 521010002765 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010002766 active site 521010002767 nucleotide binding site [chemical binding]; other site 521010002768 HIGH motif; other site 521010002769 KMSKS motif; other site 521010002770 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 521010002771 acyl carrier protein; Provisional; Region: acpP; PRK00982 521010002772 ribonuclease III; Reviewed; Region: rnc; PRK00102 521010002773 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521010002774 dimerization interface [polypeptide binding]; other site 521010002775 active site 521010002776 metal binding site [ion binding]; metal-binding site 521010002777 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 521010002778 dsRNA binding site [nucleotide binding]; other site 521010002779 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 521010002780 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521010002781 active site 521010002782 NTP binding site [chemical binding]; other site 521010002783 metal binding triad [ion binding]; metal-binding site 521010002784 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 521010002785 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 521010002786 conserved hypothetical protein, YceG family; Region: TIGR00247 521010002787 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 521010002788 dimerization interface [polypeptide binding]; other site 521010002789 DNA primase, catalytic core; Region: dnaG; TIGR01391 521010002790 CHC2 zinc finger; Region: zf-CHC2; pfam01807 521010002791 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521010002792 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521010002793 active site 521010002794 metal binding site [ion binding]; metal-binding site 521010002795 interdomain interaction site; other site 521010002796 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 521010002797 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 521010002798 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 521010002799 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521010002800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521010002801 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521010002802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521010002803 DNA binding residues [nucleotide binding] 521010002804 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 521010002805 Putative zinc ribbon domain; Region: DUF164; pfam02591 521010002806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521010002807 binding surface 521010002808 TPR repeat; Region: TPR_11; pfam13414 521010002809 TPR motif; other site 521010002810 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 521010002811 MreB and similar proteins; Region: MreB_like; cd10225 521010002812 putative protofilament interaction site [polypeptide binding]; other site 521010002813 nucleotide binding site [chemical binding]; other site 521010002814 RodZ interaction site [polypeptide binding]; other site 521010002815 Mg binding site [ion binding]; other site 521010002816 rod shape-determining protein MreC; Region: mreC; TIGR00219 521010002817 rod shape-determining protein MreC; Region: MreC; pfam04085 521010002818 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521010002819 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521010002820 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521010002821 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521010002822 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521010002823 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 521010002824 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521010002825 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521010002826 active site 521010002827 dimer interface [polypeptide binding]; other site 521010002828 motif 1; other site 521010002829 motif 2; other site 521010002830 motif 3; other site 521010002831 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 521010002832 anticodon binding site; other site 521010002833 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 521010002834 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 521010002835 putative active site; other site 521010002836 putative metal binding residues [ion binding]; other site 521010002837 signature motif; other site 521010002838 putative triphosphate binding site [ion binding]; other site 521010002839 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 521010002840 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 521010002841 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 521010002842 TrkA-N domain; Region: TrkA_N; pfam02254 521010002843 TrkA-C domain; Region: TrkA_C; pfam02080 521010002844 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521010002845 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 521010002846 P-loop; other site 521010002847 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 521010002848 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521010002849 active site 521010002850 ADP/pyrophosphate binding site [chemical binding]; other site 521010002851 dimerization interface [polypeptide binding]; other site 521010002852 allosteric effector site; other site 521010002853 fructose-1,6-bisphosphate binding site; other site 521010002854 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 521010002855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521010002856 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521010002857 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 521010002858 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 521010002859 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 521010002860 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521010002861 active site 521010002862 dimer interface [polypeptide binding]; other site 521010002863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521010002864 dimer interface [polypeptide binding]; other site 521010002865 active site 521010002866 ParB-like nuclease domain; Region: ParBc; pfam02195 521010002867 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 521010002868 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 521010002869 Transglycosylase; Region: Transgly; pfam00912 521010002870 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 521010002871 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 521010002872 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 521010002873 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 521010002874 rare lipoprotein A; Region: rlpA; TIGR00413 521010002875 Sporulation related domain; Region: SPOR; pfam05036 521010002876 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 521010002877 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521010002878 FMN binding site [chemical binding]; other site 521010002879 active site 521010002880 catalytic residues [active] 521010002881 substrate binding site [chemical binding]; other site 521010002882 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521010002883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521010002884 active site 521010002885 HIGH motif; other site 521010002886 nucleotide binding site [chemical binding]; other site 521010002887 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521010002888 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521010002889 active site 521010002890 KMSKS motif; other site 521010002891 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521010002892 tRNA binding surface [nucleotide binding]; other site 521010002893 anticodon binding site; other site 521010002894 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521010002895 Uncharacterized conserved protein [Function unknown]; Region: COG4121 521010002896 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521010002897 oligomerisation interface [polypeptide binding]; other site 521010002898 mobile loop; other site 521010002899 roof hairpin; other site 521010002900 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 521010002901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010002902 Walker A/P-loop; other site 521010002903 ATP binding site [chemical binding]; other site 521010002904 Q-loop/lid; other site 521010002905 ABC transporter signature motif; other site 521010002906 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521010002907 Walker B; other site 521010002908 D-loop; other site 521010002909 H-loop/switch region; other site 521010002910 ABC transporter; Region: ABC_tran_2; pfam12848 521010002911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521010002912 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521010002913 PQQ-like domain; Region: PQQ_2; pfam13360 521010002914 active site 521010002915 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 521010002916 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 521010002917 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521010002918 minor groove reading motif; other site 521010002919 helix-hairpin-helix signature motif; other site 521010002920 substrate binding pocket [chemical binding]; other site 521010002921 active site 521010002922 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 521010002923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002924 dimer interface [polypeptide binding]; other site 521010002925 conserved gate region; other site 521010002926 putative PBP binding loops; other site 521010002927 ABC-ATPase subunit interface; other site 521010002928 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521010002929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521010002930 ABC-ATPase subunit interface; other site 521010002931 putative PBP binding loops; other site 521010002932 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 521010002933 Septum formation initiator; Region: DivIC; pfam04977 521010002934 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 521010002935 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 521010002936 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 521010002937 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521010002938 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521010002939 Walker A/P-loop; other site 521010002940 ATP binding site [chemical binding]; other site 521010002941 Q-loop/lid; other site 521010002942 ABC transporter signature motif; other site 521010002943 Walker B; other site 521010002944 D-loop; other site 521010002945 H-loop/switch region; other site 521010002946 ribonuclease Z; Region: RNase_Z; TIGR02651 521010002947 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 521010002948 hydroxyglutarate oxidase; Provisional; Region: PRK11728 521010002949 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 521010002950 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521010002951 oligomer interface [polypeptide binding]; other site 521010002952 active site residues [active] 521010002953 Domain of unknown function (DUF368); Region: DUF368; cl00893 521010002954 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 521010002955 putative metal binding site [ion binding]; other site 521010002956 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521010002957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521010002958 Peptidase family M23; Region: Peptidase_M23; pfam01551 521010002959 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521010002960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521010002961 active site 521010002962 phosphorylation site [posttranslational modification] 521010002963 intermolecular recognition site; other site 521010002964 dimerization interface [polypeptide binding]; other site 521010002965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010002966 Walker A motif; other site 521010002967 ATP binding site [chemical binding]; other site 521010002968 Walker B motif; other site 521010002969 arginine finger; other site 521010002970 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521010002971 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 521010002972 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 521010002973 dimer interface [polypeptide binding]; other site 521010002974 phosphorylation site [posttranslational modification] 521010002975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521010002976 ATP binding site [chemical binding]; other site 521010002977 G-X-G motif; other site 521010002978 DNA polymerase III subunit delta'; Validated; Region: PRK08485 521010002979 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 521010002980 Colicin V production protein; Region: Colicin_V; pfam02674 521010002981 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 521010002982 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521010002983 homodimer interface [polypeptide binding]; other site 521010002984 active site 521010002985 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 521010002986 dimer interface [polypeptide binding]; other site 521010002987 pyridoxal binding site [chemical binding]; other site 521010002988 ATP binding site [chemical binding]; other site 521010002989 UGMP family protein; Validated; Region: PRK09604 521010002990 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521010002991 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 521010002992 NodB motif; other site 521010002993 putative active site [active] 521010002994 putative catalytic site [active] 521010002995 Zn binding site [ion binding]; other site 521010002996 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 521010002997 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521010002998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521010002999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521010003000 DNA binding residues [nucleotide binding] 521010003001 Rod binding protein; Region: Rod-binding; cl01626 521010003002 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 521010003003 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 521010003004 SAF-like; Region: SAF_2; pfam13144 521010003005 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 521010003006 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521010003007 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 521010003008 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 521010003009 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 521010003010 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 521010003011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 521010003012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010003013 active site 521010003014 ribosomal protein L21; Region: L21; TIGR00061 521010003015 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 521010003016 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 521010003017 GTPase CgtA; Reviewed; Region: obgE; PRK12299 521010003018 GTP1/OBG; Region: GTP1_OBG; pfam01018 521010003019 Obg GTPase; Region: Obg; cd01898 521010003020 G1 box; other site 521010003021 GTP/Mg2+ binding site [chemical binding]; other site 521010003022 Switch I region; other site 521010003023 G2 box; other site 521010003024 G3 box; other site 521010003025 Switch II region; other site 521010003026 G4 box; other site 521010003027 G5 box; other site 521010003028 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521010003029 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 521010003030 active site 521010003031 (T/H)XGH motif; other site 521010003032 Transcriptional regulator [Transcription]; Region: LytR; COG1316 521010003033 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 521010003034 Oligomerisation domain; Region: Oligomerisation; cl00519 521010003035 SpoVG; Region: SpoVG; cl00915 521010003036 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 521010003037 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 521010003038 5S rRNA interface [nucleotide binding]; other site 521010003039 CTC domain interface [polypeptide binding]; other site 521010003040 L16 interface [polypeptide binding]; other site 521010003041 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521010003042 putative active site [active] 521010003043 catalytic residue [active] 521010003044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 521010003045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521010003046 Ligand Binding Site [chemical binding]; other site 521010003047 FtsH Extracellular; Region: FtsH_ext; pfam06480 521010003048 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521010003049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010003050 Walker A motif; other site 521010003051 ATP binding site [chemical binding]; other site 521010003052 Walker B motif; other site 521010003053 arginine finger; other site 521010003054 Peptidase family M41; Region: Peptidase_M41; pfam01434 521010003055 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 521010003056 thymidylate kinase; Region: DTMP_kinase; TIGR00041 521010003057 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 521010003058 TMP-binding site; other site 521010003059 ATP-binding site [chemical binding]; other site 521010003060 Family of unknown function (DUF490); Region: DUF490; pfam04357 521010003061 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 521010003062 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521010003063 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521010003064 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521010003065 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521010003066 Surface antigen; Region: Bac_surface_Ag; pfam01103 521010003067 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 521010003068 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 521010003069 MutS domain I; Region: MutS_I; pfam01624 521010003070 MutS domain II; Region: MutS_II; pfam05188 521010003071 MutS domain III; Region: MutS_III; pfam05192 521010003072 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 521010003073 Walker A/P-loop; other site 521010003074 ATP binding site [chemical binding]; other site 521010003075 Q-loop/lid; other site 521010003076 ABC transporter signature motif; other site 521010003077 Walker B; other site 521010003078 D-loop; other site 521010003079 H-loop/switch region; other site 521010003080 comF family protein; Region: comF; TIGR00201 521010003081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521010003082 active site 521010003083 Sm and related proteins; Region: Sm_like; cl00259 521010003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 521010003085 heptamer interface [polypeptide binding]; other site 521010003086 Sm1 motif; other site 521010003087 hexamer interface [polypeptide binding]; other site 521010003088 RNA binding site [nucleotide binding]; other site 521010003089 Sm2 motif; other site 521010003090 transcription termination factor NusA; Region: NusA; TIGR01953 521010003091 NusA N-terminal domain; Region: NusA_N; pfam08529 521010003092 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521010003093 RNA binding site [nucleotide binding]; other site 521010003094 homodimer interface [polypeptide binding]; other site 521010003095 NusA-like KH domain; Region: KH_5; pfam13184 521010003096 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521010003097 G-X-X-G motif; other site 521010003098 translation initiation factor IF-2; Region: IF-2; TIGR00487 521010003099 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521010003100 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521010003101 G1 box; other site 521010003102 putative GEF interaction site [polypeptide binding]; other site 521010003103 GTP/Mg2+ binding site [chemical binding]; other site 521010003104 Switch I region; other site 521010003105 G2 box; other site 521010003106 G3 box; other site 521010003107 Switch II region; other site 521010003108 G4 box; other site 521010003109 G5 box; other site 521010003110 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521010003111 Translation-initiation factor 2; Region: IF-2; pfam11987 521010003112 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521010003113 ribosome-binding factor A; Region: rbfA; TIGR00082 521010003114 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 521010003115 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 521010003116 RNA binding site [nucleotide binding]; other site 521010003117 active site 521010003118 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521010003119 16S/18S rRNA binding site [nucleotide binding]; other site 521010003120 S13e-L30e interaction site [polypeptide binding]; other site 521010003121 25S rRNA binding site [nucleotide binding]; other site 521010003122 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521010003123 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521010003124 RNase E interface [polypeptide binding]; other site 521010003125 trimer interface [polypeptide binding]; other site 521010003126 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521010003127 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521010003128 RNase E interface [polypeptide binding]; other site 521010003129 trimer interface [polypeptide binding]; other site 521010003130 active site 521010003131 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 521010003132 putative nucleic acid binding region [nucleotide binding]; other site 521010003133 G-X-X-G motif; other site 521010003134 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521010003135 RNA binding site [nucleotide binding]; other site 521010003136 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521010003137 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521010003138 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521010003139 Predicted permeases [General function prediction only]; Region: COG0795 521010003140 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521010003141 tRNA-guanine transglycosylase, queuosine-34-forming; Region: Q_tRNA_tgt; TIGR00430 521010003142 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 521010003143 integral membrane protein MviN; Region: mviN; TIGR01695 521010003144 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 521010003145 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 521010003146 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 521010003147 Flavoprotein; Region: Flavoprotein; pfam02441 521010003148 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 521010003149 sodium/panthothenate symporter; Provisional; Region: panF; PRK09442 521010003150 Na binding site [ion binding]; other site 521010003151 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521010003152 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521010003153 active site 521010003154 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 521010003155 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521010003156 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521010003157 TIGR00255 family protein; Region: TIGR00255 521010003158 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 521010003159 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 521010003160 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 521010003161 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521010003162 CMP-binding site; other site 521010003163 The sites determining sugar specificity; other site 521010003164 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 521010003165 tRNA delta(2)-isopentenylpyrophosphate transferase; Provisional; Region: miaA; PRK14729 521010003166 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 521010003167 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 521010003168 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 521010003169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010003170 ATP binding site [chemical binding]; other site 521010003171 putative Mg++ binding site [ion binding]; other site 521010003172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010003173 nucleotide binding region [chemical binding]; other site 521010003174 ATP-binding site [chemical binding]; other site 521010003175 Helicase associated domain (HA2); Region: HA2; pfam04408 521010003176 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 521010003177 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 521010003178 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 521010003179 active site 521010003180 interdomain interaction site; other site 521010003181 putative metal-binding site [ion binding]; other site 521010003182 nucleotide binding site [chemical binding]; other site 521010003183 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 521010003184 domain I; other site 521010003185 phosphate binding site [ion binding]; other site 521010003186 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521010003187 domain III; other site 521010003188 nucleotide binding site [chemical binding]; other site 521010003189 DNA binding groove [nucleotide binding] 521010003190 catalytic site [active] 521010003191 domain II; other site 521010003192 domain IV; other site 521010003193 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 521010003194 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 521010003195 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 521010003196 active site 521010003197 metal binding site [ion binding]; metal-binding site 521010003198 DNA binding site [nucleotide binding] 521010003199 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 521010003200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010003201 Walker A/P-loop; other site 521010003202 ATP binding site [chemical binding]; other site 521010003203 Q-loop/lid; other site 521010003204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521010003205 ABC transporter signature motif; other site 521010003206 Walker B; other site 521010003207 D-loop; other site 521010003208 H-loop/switch region; other site 521010003209 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521010003210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521010003211 nucleotide binding site [chemical binding]; other site 521010003212 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 521010003213 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521010003214 HIGH motif; other site 521010003215 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521010003216 active site 521010003217 KMSKS motif; other site 521010003218 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 521010003219 tRNA binding surface [nucleotide binding]; other site 521010003220 anticodon binding site; other site 521010003221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010003222 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521010003223 Walker A motif; other site 521010003224 ATP binding site [chemical binding]; other site 521010003225 Walker B motif; other site 521010003226 arginine finger; other site 521010003227 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521010003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521010003229 Walker A motif; other site 521010003230 ATP binding site [chemical binding]; other site 521010003231 Walker B motif; other site 521010003232 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 521010003233 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521010003234 active site 521010003235 substrate binding site [chemical binding]; other site 521010003236 metal binding site [ion binding]; metal-binding site 521010003237 excinuclease ABC subunit B; Provisional; Region: PRK05298 521010003238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521010003239 ATP binding site [chemical binding]; other site 521010003240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521010003241 nucleotide binding region [chemical binding]; other site 521010003242 ATP-binding site [chemical binding]; other site 521010003243 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521010003244 UvrB/uvrC motif; Region: UVR; pfam02151 521010003245 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521010003246 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521010003247 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521010003248 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521010003249 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 521010003250 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 521010003251 RNA/DNA hybrid binding site [nucleotide binding]; other site 521010003252 active site 521010003253 arginine deiminase; Provisional; Region: PRK01388 521010003254 ornithine carbamoyltransferase; Provisional; Region: PRK04284 521010003255 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521010003256 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521010003257 Predicted membrane protein [Function unknown]; Region: COG1288 521010003258 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 521010003259 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521010003260 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 521010003261 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521010003262 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010003263 P-loop; other site 521010003264 Magnesium ion binding site [ion binding]; other site 521010003265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521010003266 Magnesium ion binding site [ion binding]; other site 521010003267 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 521010003268 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 521010003269 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 521010003270 catalytic triad [active] 521010003271 conserved cis-peptide bond; other site 521010003272 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714