-- dump date 20140619_004259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 390236000001 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000002 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236000003 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000004 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000005 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000006 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236000007 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236000008 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000009 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000010 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000011 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000012 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000013 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000014 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000015 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000016 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236000017 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000018 DUF276; Region: DUF276; pfam03434 390236000019 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000020 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000021 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000022 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 390236000023 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000024 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000025 ERF superfamily; Region: ERF; pfam04404 390236000026 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000027 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000028 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000029 P-loop; other site 390236000030 Magnesium ion binding site [ion binding]; other site 390236000031 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000032 Magnesium ion binding site [ion binding]; other site 390236000033 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000034 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000035 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000036 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000037 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000038 active site 390236000039 catalytic residues [active] 390236000040 DNA binding site [nucleotide binding] 390236000041 Int/Topo IB signature motif; other site 390236000042 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236000043 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236000044 Protein of unknown function (DUF643); Region: DUF643; pfam04867 390236000045 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000046 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000047 Terminase-like family; Region: Terminase_6; pfam03237 390236000048 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000049 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236000050 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000051 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000052 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000053 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236000054 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236000055 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000056 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000057 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000058 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000059 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000060 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000061 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000062 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000063 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236000064 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000065 DUF276; Region: DUF276; pfam03434 390236000066 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000067 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000068 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000069 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 390236000070 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000071 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000072 ERF superfamily; Region: ERF; pfam04404 390236000073 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000074 Z1 domain; Region: Z1; pfam10593 390236000075 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000076 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000077 P-loop; other site 390236000078 Magnesium ion binding site [ion binding]; other site 390236000079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000080 Magnesium ion binding site [ion binding]; other site 390236000081 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000082 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 390236000083 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000084 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000085 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000086 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000087 active site 390236000088 catalytic residues [active] 390236000089 DNA binding site [nucleotide binding] 390236000090 Int/Topo IB signature motif; other site 390236000091 Borrelia outer surface protein E; Region: OspE; pfam02471 390236000092 Erp protein C-terminus; Region: Erp_C; pfam06780 390236000093 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000094 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000095 Terminase-like family; Region: Terminase_6; pfam03237 390236000096 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000097 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236000098 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000099 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000100 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000101 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236000102 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236000103 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000104 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000105 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000106 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000107 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000108 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000109 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000110 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000111 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236000112 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000113 DUF276; Region: DUF276; pfam03434 390236000114 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000115 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000116 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000117 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 390236000118 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000119 AAA domain; Region: AAA_13; pfam13166 390236000120 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000121 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000122 ERF superfamily; Region: ERF; pfam04404 390236000123 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000124 Z1 domain; Region: Z1; pfam10593 390236000125 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000126 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000127 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000128 P-loop; other site 390236000129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000130 Magnesium ion binding site [ion binding]; other site 390236000131 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000132 membrane glycoprotein; Provisional; Region: PHA03332 390236000133 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000134 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000135 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000136 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000137 active site 390236000138 catalytic residues [active] 390236000139 DNA binding site [nucleotide binding] 390236000140 Int/Topo IB signature motif; other site 390236000141 Erp protein C-terminus; Region: Erp_C; pfam06780 390236000142 Protein of unknown function (DUF643); Region: DUF643; pfam04867 390236000143 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000144 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000145 Terminase-like family; Region: Terminase_6; pfam03237 390236000146 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000147 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236000148 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000149 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000150 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000151 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236000152 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236000153 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000154 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000155 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000156 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000157 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000158 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000159 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000160 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000161 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236000162 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000163 DUF276; Region: DUF276; pfam03434 390236000164 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000165 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000166 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000167 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 390236000168 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000169 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 390236000170 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000171 ERF superfamily; Region: ERF; pfam04404 390236000172 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000173 Z1 domain; Region: Z1; pfam10593 390236000174 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000175 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000176 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000177 P-loop; other site 390236000178 Magnesium ion binding site [ion binding]; other site 390236000179 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000180 Magnesium ion binding site [ion binding]; other site 390236000181 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000182 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 390236000183 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000184 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000185 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000186 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000187 active site 390236000188 catalytic residues [active] 390236000189 DNA binding site [nucleotide binding] 390236000190 Int/Topo IB signature motif; other site 390236000191 Protein of unknown function (DUF643); Region: DUF643; pfam04867 390236000192 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000193 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000194 Terminase-like family; Region: Terminase_6; pfam03237 390236000195 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000196 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236000197 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000198 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000199 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000200 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236000201 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236000202 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000203 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000204 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000205 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000206 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000207 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000208 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000209 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000210 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000211 DUF276; Region: DUF276; pfam03434 390236000212 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000213 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000214 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000215 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000216 ERF superfamily; Region: ERF; pfam04404 390236000217 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000218 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000219 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000220 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000221 P-loop; other site 390236000222 Magnesium ion binding site [ion binding]; other site 390236000223 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000224 Magnesium ion binding site [ion binding]; other site 390236000225 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000226 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 390236000227 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000228 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000229 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000230 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000231 active site 390236000232 catalytic residues [active] 390236000233 DNA binding site [nucleotide binding] 390236000234 Int/Topo IB signature motif; other site 390236000235 Borrelia outer surface protein E; Region: OspE; pfam02471 390236000236 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236000237 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000238 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000239 Terminase-like family; Region: Terminase_6; pfam03237 390236000240 acylphosphatase; Provisional; Region: PRK14432 390236000241 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 390236000242 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 390236000243 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 390236000244 methionine cluster; other site 390236000245 active site 390236000246 phosphorylation site [posttranslational modification] 390236000247 metal binding site [ion binding]; metal-binding site 390236000248 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 390236000249 active site 390236000250 P-loop; other site 390236000251 phosphorylation site [posttranslational modification] 390236000252 Uncharacterized conserved protein [Function unknown]; Region: COG3589 390236000253 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 390236000254 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000255 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000256 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000257 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000258 P-loop; other site 390236000259 Magnesium ion binding site [ion binding]; other site 390236000260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 390236000261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000262 Magnesium ion binding site [ion binding]; other site 390236000263 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000264 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390236000265 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390236000266 peptide binding site [polypeptide binding]; other site 390236000267 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 390236000268 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 390236000269 active site 390236000270 GMP synthase; Reviewed; Region: guaA; PRK00074 390236000271 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 390236000272 AMP/PPi binding site [chemical binding]; other site 390236000273 candidate oxyanion hole; other site 390236000274 catalytic triad [active] 390236000275 potential glutamine specificity residues [chemical binding]; other site 390236000276 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 390236000277 ATP Binding subdomain [chemical binding]; other site 390236000278 Ligand Binding sites [chemical binding]; other site 390236000279 Dimerization subdomain; other site 390236000280 Lipoprotein; Region: Lipoprotein_6; pfam01441 390236000281 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 390236000282 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 390236000283 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 390236000284 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 390236000285 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 390236000286 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 390236000287 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 390236000288 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 390236000289 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 390236000290 active site turn [active] 390236000291 phosphorylation site [posttranslational modification] 390236000292 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000293 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236000294 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000295 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000296 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236000297 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236000298 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236000299 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000300 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000301 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000302 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000303 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000304 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000305 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000306 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000307 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236000308 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000309 DUF276; Region: DUF276; pfam03434 390236000310 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000311 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000312 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000313 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 390236000314 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000315 AAA domain; Region: AAA_13; pfam13166 390236000316 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000317 ERF superfamily; Region: ERF; pfam04404 390236000318 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000319 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000320 AAA domain; Region: AAA_31; pfam13614 390236000321 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000322 P-loop; other site 390236000323 Magnesium ion binding site [ion binding]; other site 390236000324 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000325 Magnesium ion binding site [ion binding]; other site 390236000326 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000327 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000328 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000329 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000330 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000331 active site 390236000332 catalytic residues [active] 390236000333 DNA binding site [nucleotide binding] 390236000334 Int/Topo IB signature motif; other site 390236000335 Erp protein C-terminus; Region: Erp_C; pfam06780 390236000336 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000337 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000338 Terminase-like family; Region: Terminase_6; pfam03237 390236000339 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236000340 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236000341 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236000342 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236000343 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236000344 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236000345 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 390236000346 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236000347 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236000348 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236000349 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236000350 DUF276; Region: DUF276; pfam03434 390236000351 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236000352 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236000353 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 390236000354 Borrelia burgdorferi BBR25 lipoprotein; Region: Borrelia_lipo_2; pfam06238 390236000355 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000356 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000357 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000358 ERF superfamily; Region: ERF; pfam04404 390236000359 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000360 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000361 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000362 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000363 P-loop; other site 390236000364 Magnesium ion binding site [ion binding]; other site 390236000365 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000366 Magnesium ion binding site [ion binding]; other site 390236000367 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000368 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 390236000369 Uncharacterized protein family (ORF7) DUF; Region: DUF244; pfam03112 390236000370 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000371 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236000372 active site 390236000373 catalytic residues [active] 390236000374 DNA binding site [nucleotide binding] 390236000375 Int/Topo IB signature motif; other site 390236000376 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236000377 Phage terminase large subunit; Region: Terminase_3; cl12054 390236000378 Terminase-like family; Region: Terminase_6; pfam03237 390236000379 Probable transposase; Region: OrfB_IS605; pfam01385 390236000380 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 390236000381 Probable transposase; Region: OrfB_IS605; pfam01385 390236000382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 390236000383 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 390236000384 Transposase IS200 like; Region: Y1_Tnp; pfam01797 390236000385 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000386 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000387 P-loop; other site 390236000388 Magnesium ion binding site [ion binding]; other site 390236000389 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000390 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000391 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 390236000392 TM2 domain; Region: TM2; pfam05154 390236000393 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 390236000395 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 390236000396 Probable transposase; Region: OrfB_IS605; pfam01385 390236000397 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 390236000398 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 390236000399 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000400 potential frameshift: common BLAST hit: gi|219052339|ref|YP_002455710.1| transporter major facilitator family protein 390236000401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 390236000402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 390236000403 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 390236000404 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 390236000405 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236000406 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000407 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000408 AAA domain; Region: AAA_31; pfam13614 390236000409 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000410 P-loop; other site 390236000411 Magnesium ion binding site [ion binding]; other site 390236000412 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000413 Magnesium ion binding site [ion binding]; other site 390236000414 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000415 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 390236000416 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000417 Erp protein C-terminus; Region: Erp_C; pfam06780 390236000418 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000419 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000420 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000421 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000422 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000423 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000425 P-loop; other site 390236000426 Magnesium ion binding site [ion binding]; other site 390236000427 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000428 Magnesium ion binding site [ion binding]; other site 390236000429 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000430 Erp protein C-terminus; Region: Erp_C; pfam06780 390236000431 Mlp lipoprotein family; Region: Mlp; pfam03304 390236000432 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 390236000433 Uncharacterized conserved protein [Function unknown]; Region: COG4748 390236000434 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 390236000435 Uncharacterized conserved protein [Function unknown]; Region: COG3586 390236000436 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 390236000437 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 390236000438 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236000439 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236000440 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000441 AAA domain; Region: AAA_31; pfam13614 390236000442 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000443 P-loop; other site 390236000444 Magnesium ion binding site [ion binding]; other site 390236000445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000446 Magnesium ion binding site [ion binding]; other site 390236000447 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000448 potential frameshift: common BLAST hit: gi|219723497|ref|YP_002476755.1| tape measure domain protein 390236000449 Right handed beta helix region; Region: Beta_helix; pfam13229 390236000450 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236000451 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236000452 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000453 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000454 replicative DNA helicase; Region: DnaB; TIGR00665 390236000455 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 390236000456 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390236000457 Walker A motif; other site 390236000458 ATP binding site [chemical binding]; other site 390236000459 Walker B motif; other site 390236000460 ribonuclease Y; Region: RNase_Y; TIGR03319 390236000461 CAAX protease self-immunity; Region: Abi; pfam02517 390236000462 YcaO-like family; Region: YcaO; pfam02624 390236000463 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 390236000464 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 390236000465 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 390236000466 putative FMN binding site [chemical binding]; other site 390236000467 NADPH bind site [chemical binding]; other site 390236000468 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 390236000469 FtsX-like permease family; Region: FtsX; pfam02687 390236000470 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390236000471 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390236000472 Walker A/P-loop; other site 390236000473 ATP binding site [chemical binding]; other site 390236000474 Q-loop/lid; other site 390236000475 ABC transporter signature motif; other site 390236000476 Walker B; other site 390236000477 D-loop; other site 390236000478 H-loop/switch region; other site 390236000479 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 390236000480 putative active site [active] 390236000481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 390236000482 TPR motif; other site 390236000483 binding surface 390236000484 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000485 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000487 P-loop; other site 390236000488 Magnesium ion binding site [ion binding]; other site 390236000489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000490 Magnesium ion binding site [ion binding]; other site 390236000491 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000492 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000493 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 390236000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 390236000495 adenine deaminase; Region: ade; TIGR01178 390236000496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 390236000497 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 390236000498 active site 390236000499 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 390236000500 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000501 Borrelia burgdorferi REV protein; Region: Borrelia_REV; pfam03978 390236000502 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 390236000503 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 390236000504 potential frameshift: common BLAST hit: gi|219049310|ref|YP_002455657.1| virulent strain associated lipoprotein 390236000505 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000506 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000507 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000508 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236000509 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236000510 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000511 P-loop; other site 390236000512 Magnesium ion binding site [ion binding]; other site 390236000513 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236000514 Magnesium ion binding site [ion binding]; other site 390236000515 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236000516 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000517 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 390236000519 Probable transposase; Region: OrfB_IS605; pfam01385 390236000520 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000521 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236000522 flavoprotein, HI0933 family; Region: TIGR00275 390236000523 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 390236000524 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 390236000525 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 390236000526 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236000527 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 390236000528 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 390236000529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 390236000530 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 390236000531 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 390236000532 active site 390236000533 substrate binding site [chemical binding]; other site 390236000534 metal binding site [ion binding]; metal-binding site 390236000535 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 390236000536 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 390236000537 active site 390236000538 HIGH motif; other site 390236000539 dimer interface [polypeptide binding]; other site 390236000540 KMSKS motif; other site 390236000541 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 390236000542 Domain of unknown function DUF20; Region: UPF0118; pfam01594 390236000543 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 390236000544 TIGR00159 family protein; Region: TIGR00159 390236000545 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 390236000546 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 390236000547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 390236000548 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 390236000549 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 390236000550 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 390236000551 dimerization interface 3.5A [polypeptide binding]; other site 390236000552 active site 390236000553 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 390236000554 primosomal protein N' Region: priA; TIGR00595 390236000555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390236000556 ATP binding site [chemical binding]; other site 390236000557 putative Mg++ binding site [ion binding]; other site 390236000558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390236000559 nucleotide binding region [chemical binding]; other site 390236000560 ATP-binding site [chemical binding]; other site 390236000561 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 390236000562 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 390236000563 ATP-binding site [chemical binding]; other site 390236000564 Sugar specificity; other site 390236000565 Pyrimidine base specificity; other site 390236000566 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 390236000567 active site residue [active] 390236000568 Uncharacterized conserved protein [Function unknown]; Region: COG1284 390236000569 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 390236000570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 390236000571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 390236000572 active site 390236000573 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 390236000574 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 390236000575 active site 390236000576 ADP/pyrophosphate binding site [chemical binding]; other site 390236000577 dimerization interface [polypeptide binding]; other site 390236000578 allosteric effector site; other site 390236000579 fructose-1,6-bisphosphate binding site; other site 390236000580 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 390236000581 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 390236000582 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 390236000583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236000584 Walker A motif; other site 390236000585 ATP binding site [chemical binding]; other site 390236000586 Walker B motif; other site 390236000587 arginine finger; other site 390236000588 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 390236000589 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 390236000590 RuvA N terminal domain; Region: RuvA_N; pfam01330 390236000591 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 390236000592 hypothetical protein; Validated; Region: PRK00110 390236000593 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 390236000594 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 390236000595 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 390236000596 homodimer interface [polypeptide binding]; other site 390236000597 NADP binding site [chemical binding]; other site 390236000598 substrate binding site [chemical binding]; other site 390236000599 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 390236000600 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 390236000601 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 390236000602 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 390236000603 Catalytic site [active] 390236000604 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 390236000605 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 390236000606 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 390236000607 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 390236000608 SmpB-tmRNA interface; other site 390236000609 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 390236000610 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 390236000611 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 390236000612 CAP-like domain; other site 390236000613 active site 390236000614 primary dimer interface [polypeptide binding]; other site 390236000615 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 390236000616 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 390236000617 ATP binding site [chemical binding]; other site 390236000618 Mg2+ binding site [ion binding]; other site 390236000619 G-X-G motif; other site 390236000620 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 390236000621 anchoring element; other site 390236000622 dimer interface [polypeptide binding]; other site 390236000623 ATP binding site [chemical binding]; other site 390236000624 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 390236000625 active site 390236000626 putative metal-binding site [ion binding]; other site 390236000627 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 390236000628 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 390236000629 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 390236000630 putative acyl-acceptor binding pocket; other site 390236000631 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 390236000632 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 390236000633 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 390236000634 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 390236000635 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 390236000636 PhoU domain; Region: PhoU; pfam01895 390236000637 PhoU domain; Region: PhoU; pfam01895 390236000638 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 390236000639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236000640 Walker A/P-loop; other site 390236000641 ATP binding site [chemical binding]; other site 390236000642 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 390236000643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236000644 ABC transporter signature motif; other site 390236000645 Walker B; other site 390236000646 D-loop; other site 390236000647 H-loop/switch region; other site 390236000648 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 390236000649 RNA/DNA hybrid binding site [nucleotide binding]; other site 390236000650 active site 390236000651 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 390236000652 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 390236000653 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 390236000654 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 390236000655 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 390236000656 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 390236000657 ligand binding site [chemical binding]; other site 390236000658 active site 390236000659 UGI interface [polypeptide binding]; other site 390236000660 catalytic site [active] 390236000661 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 390236000662 triosephosphate isomerase; Provisional; Region: PRK14565 390236000663 substrate binding site [chemical binding]; other site 390236000664 dimer interface [polypeptide binding]; other site 390236000665 catalytic triad [active] 390236000666 Phosphoglycerate kinase; Region: PGK; pfam00162 390236000667 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 390236000668 substrate binding site [chemical binding]; other site 390236000669 hinge regions; other site 390236000670 ADP binding site [chemical binding]; other site 390236000671 catalytic site [active] 390236000672 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 390236000673 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 390236000674 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 390236000675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236000676 binding surface 390236000677 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236000678 TPR motif; other site 390236000679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236000680 TPR motif; other site 390236000681 binding surface 390236000682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236000683 binding surface 390236000684 TPR motif; other site 390236000685 TPR repeat; Region: TPR_11; pfam13414 390236000686 FOG: CBS domain [General function prediction only]; Region: COG0517 390236000687 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 390236000688 Transporter associated domain; Region: CorC_HlyC; smart01091 390236000689 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 390236000690 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 390236000691 catalytic residues [active] 390236000692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 390236000693 RNA methyltransferase, RsmE family; Region: TIGR00046 390236000694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 390236000695 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 390236000696 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 390236000697 PASTA domain; Region: PASTA; smart00740 390236000698 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 390236000699 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 390236000700 putative active site [active] 390236000701 substrate binding site [chemical binding]; other site 390236000702 putative cosubstrate binding site; other site 390236000703 catalytic site [active] 390236000704 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 390236000705 substrate binding site [chemical binding]; other site 390236000706 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 390236000707 active site 390236000708 catalytic residues [active] 390236000709 metal binding site [ion binding]; metal-binding site 390236000710 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 390236000711 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 390236000712 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 390236000713 active site 390236000714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 390236000715 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 390236000716 active site 390236000717 motif I; other site 390236000718 motif II; other site 390236000719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 390236000720 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 390236000721 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 390236000722 Divergent PAP2 family; Region: DUF212; cl00855 390236000723 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 390236000724 This domain is found in peptide chain release factors; Region: PCRF; smart00937 390236000725 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 390236000726 RF-1 domain; Region: RF-1; pfam00472 390236000727 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 390236000728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 390236000729 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 390236000730 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 390236000731 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 390236000732 Walker A/P-loop; other site 390236000733 ATP binding site [chemical binding]; other site 390236000734 Q-loop/lid; other site 390236000735 ABC transporter signature motif; other site 390236000736 Walker B; other site 390236000737 D-loop; other site 390236000738 H-loop/switch region; other site 390236000739 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 390236000740 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 390236000741 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 390236000742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 390236000743 catalytic residue [active] 390236000744 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 390236000745 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 390236000746 active site 390236000747 trimerization site [polypeptide binding]; other site 390236000748 Mg chelatase-related protein; Region: TIGR00368 390236000749 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 390236000750 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 390236000751 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 390236000752 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 390236000753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390236000754 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 390236000755 NAD binding site [chemical binding]; other site 390236000756 dimer interface [polypeptide binding]; other site 390236000757 substrate binding site [chemical binding]; other site 390236000758 GTP-binding protein LepA; Provisional; Region: PRK05433 390236000759 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 390236000760 G1 box; other site 390236000761 putative GEF interaction site [polypeptide binding]; other site 390236000762 GTP/Mg2+ binding site [chemical binding]; other site 390236000763 Switch I region; other site 390236000764 G2 box; other site 390236000765 G3 box; other site 390236000766 Switch II region; other site 390236000767 G4 box; other site 390236000768 G5 box; other site 390236000769 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 390236000770 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 390236000771 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 390236000772 V-type ATP synthase subunit K; Validated; Region: PRK06649 390236000773 V-type ATP synthase subunit I; Validated; Region: PRK05771 390236000774 V-type ATP synthase subunit D; Provisional; Region: PRK02195 390236000775 V-type ATP synthase subunit B; Provisional; Region: PRK02118 390236000776 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 390236000777 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 390236000778 Walker A motif homologous position; other site 390236000779 Walker B motif; other site 390236000780 V-type ATP synthase subunit A; Provisional; Region: PRK04192 390236000781 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 390236000782 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 390236000783 Walker A motif/ATP binding site; other site 390236000784 Walker B motif; other site 390236000785 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 390236000786 V-type ATP synthase subunit E; Provisional; Region: PRK01558 390236000787 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 390236000788 MutS2 family protein; Region: mutS2; TIGR01069 390236000789 MutS domain III; Region: MutS_III; pfam05192 390236000790 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 390236000791 Walker A/P-loop; other site 390236000792 ATP binding site [chemical binding]; other site 390236000793 Q-loop/lid; other site 390236000794 ABC transporter signature motif; other site 390236000795 Walker B; other site 390236000796 D-loop; other site 390236000797 H-loop/switch region; other site 390236000798 Smr domain; Region: Smr; pfam01713 390236000799 ribosome small subunit-dependent GTPase A; Region: TIGR00157 390236000800 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 390236000801 GTPase/Zn-binding domain interface [polypeptide binding]; other site 390236000802 GTP/Mg2+ binding site [chemical binding]; other site 390236000803 G4 box; other site 390236000804 G5 box; other site 390236000805 G1 box; other site 390236000806 Switch I region; other site 390236000807 G2 box; other site 390236000808 G3 box; other site 390236000809 Switch II region; other site 390236000810 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 390236000811 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 390236000812 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 390236000813 putative dimer interface [polypeptide binding]; other site 390236000814 putative anticodon binding site; other site 390236000815 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 390236000816 homodimer interface [polypeptide binding]; other site 390236000817 motif 1; other site 390236000818 motif 2; other site 390236000819 active site 390236000820 motif 3; other site 390236000821 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 390236000822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390236000823 active site 390236000824 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 390236000825 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 390236000826 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 390236000827 protein binding site [polypeptide binding]; other site 390236000828 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 390236000829 protein binding site [polypeptide binding]; other site 390236000830 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 390236000831 active site 390236000832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236000833 TPR motif; other site 390236000834 binding surface 390236000835 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 390236000836 putative RNA binding site [nucleotide binding]; other site 390236000837 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 390236000838 SurA N-terminal domain; Region: SurA_N; pfam09312 390236000839 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 390236000840 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 390236000841 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 390236000842 dimer interface [polypeptide binding]; other site 390236000843 active site 390236000844 replicative DNA helicase; Region: DnaB; TIGR00665 390236000845 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 390236000846 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 390236000847 Walker A motif; other site 390236000848 ATP binding site [chemical binding]; other site 390236000849 Walker B motif; other site 390236000850 DNA binding loops [nucleotide binding] 390236000851 ribosomal protein L9; Region: L9; TIGR00158 390236000852 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 390236000853 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 390236000854 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 390236000855 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 390236000856 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 390236000857 dimer interface [polypeptide binding]; other site 390236000858 ssDNA binding site [nucleotide binding]; other site 390236000859 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390236000860 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 390236000861 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 390236000862 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 390236000863 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 390236000864 active site turn [active] 390236000865 phosphorylation site [posttranslational modification] 390236000866 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 390236000867 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 390236000868 RIP metalloprotease RseP; Region: TIGR00054 390236000869 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 390236000870 active site 390236000871 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 390236000872 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 390236000873 protein binding site [polypeptide binding]; other site 390236000874 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 390236000875 putative substrate binding region [chemical binding]; other site 390236000876 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 390236000877 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 390236000878 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14837 390236000879 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 390236000880 catalytic residue [active] 390236000881 putative FPP diphosphate binding site; other site 390236000882 putative FPP binding hydrophobic cleft; other site 390236000883 dimer interface [polypeptide binding]; other site 390236000884 putative IPP diphosphate binding site; other site 390236000885 ribosome recycling factor; Reviewed; Region: frr; PRK00083 390236000886 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 390236000887 hinge region; other site 390236000888 translation elongation factor Ts; Region: tsf; TIGR00116 390236000889 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 390236000890 Elongation factor TS; Region: EF_TS; pfam00889 390236000891 Elongation factor TS; Region: EF_TS; pfam00889 390236000892 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 390236000893 rRNA interaction site [nucleotide binding]; other site 390236000894 S8 interaction site; other site 390236000895 putative laminin-1 binding site; other site 390236000896 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 390236000897 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 390236000898 RNA binding site [nucleotide binding]; other site 390236000899 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 390236000900 RNA binding site [nucleotide binding]; other site 390236000901 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 390236000902 RNA binding site [nucleotide binding]; other site 390236000903 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 390236000904 RNA binding site [nucleotide binding]; other site 390236000905 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 390236000906 cytidylate kinase; Region: cmk; TIGR00017 390236000907 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 390236000908 CMP-binding site; other site 390236000909 The sites determining sugar specificity; other site 390236000910 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 390236000911 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390236000912 RNA binding surface [nucleotide binding]; other site 390236000913 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 390236000914 active site 390236000915 recombinase A; Provisional; Region: recA; PRK09354 390236000916 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 390236000917 hexamer interface [polypeptide binding]; other site 390236000918 Walker A motif; other site 390236000919 ATP binding site [chemical binding]; other site 390236000920 Walker B motif; other site 390236000921 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 390236000922 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 390236000923 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 390236000924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236000925 binding surface 390236000926 TPR motif; other site 390236000927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 390236000928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236000929 binding surface 390236000930 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236000931 TPR motif; other site 390236000932 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 390236000933 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 390236000934 dimer interface [polypeptide binding]; other site 390236000935 motif 1; other site 390236000936 active site 390236000937 motif 2; other site 390236000938 motif 3; other site 390236000939 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 390236000940 anticodon binding site; other site 390236000941 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 390236000942 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 390236000943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 390236000944 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 390236000945 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 390236000946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 390236000947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 390236000948 acyl-activating enzyme (AAE) consensus motif; other site 390236000949 CoA binding site [chemical binding]; other site 390236000950 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 390236000951 AMP binding site [chemical binding]; other site 390236000952 active site 390236000953 CoA binding site [chemical binding]; other site 390236000954 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 390236000955 Protein export membrane protein; Region: SecD_SecF; cl14618 390236000956 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 390236000957 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 390236000958 lipoyl-biotinyl attachment site [posttranslational modification]; other site 390236000959 HlyD family secretion protein; Region: HlyD_3; pfam13437 390236000960 Outer membrane efflux protein; Region: OEP; pfam02321 390236000961 Outer membrane efflux protein; Region: OEP; pfam02321 390236000962 Haemolytic domain; Region: Haemolytic; cl00506 390236000963 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 390236000964 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 390236000965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 390236000966 dimer interface [polypeptide binding]; other site 390236000967 conserved gate region; other site 390236000968 ABC-ATPase subunit interface; other site 390236000969 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 390236000970 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 390236000971 Walker A/P-loop; other site 390236000972 ATP binding site [chemical binding]; other site 390236000973 Q-loop/lid; other site 390236000974 ABC transporter signature motif; other site 390236000975 Walker B; other site 390236000976 D-loop; other site 390236000977 H-loop/switch region; other site 390236000978 flagellin; Provisional; Region: PRK12803 390236000979 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 390236000980 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 390236000981 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 390236000982 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 390236000983 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 390236000984 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 390236000985 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 390236000986 active site 390236000987 dimer interface [polypeptide binding]; other site 390236000988 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 390236000989 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 390236000990 active site 390236000991 trimer interface [polypeptide binding]; other site 390236000992 allosteric site; other site 390236000993 active site lid [active] 390236000994 hexamer (dimer of trimers) interface [polypeptide binding]; other site 390236000995 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 390236000996 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 390236000997 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 390236000998 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 390236000999 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 390236001000 SEC-C motif; Region: SEC-C; pfam02810 390236001001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 390236001002 alanine racemase; Region: alr; TIGR00492 390236001003 active site 390236001004 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 390236001005 dimer interface [polypeptide binding]; other site 390236001006 substrate binding site [chemical binding]; other site 390236001007 catalytic residues [active] 390236001008 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 390236001009 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 390236001010 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 390236001011 Uncharacterized conserved protein [Function unknown]; Region: COG1306 390236001012 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 390236001013 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 390236001014 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 390236001015 ligand binding site [chemical binding]; other site 390236001016 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 390236001017 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 390236001018 rRNA binding site [nucleotide binding]; other site 390236001019 predicted 30S ribosome binding site; other site 390236001020 Oxygen tolerance; Region: BatD; pfam13584 390236001021 TPR repeat; Region: TPR_11; pfam13414 390236001022 Bacterial SH3 domain homologues; Region: SH3b; smart00287 390236001023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001024 TPR repeat; Region: TPR_11; pfam13414 390236001025 binding surface 390236001026 TPR motif; other site 390236001027 Tetratricopeptide repeat; Region: TPR_12; pfam13424 390236001028 von Willebrand factor type A domain; Region: VWA_2; pfam13519 390236001029 metal ion-dependent adhesion site (MIDAS); other site 390236001030 Aerotolerance regulator N-terminal; Region: BatA; cl06567 390236001031 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 390236001032 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 390236001033 metal ion-dependent adhesion site (MIDAS); other site 390236001034 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 390236001035 Protein of unknown function DUF58; Region: DUF58; pfam01882 390236001036 MoxR-like ATPases [General function prediction only]; Region: COG0714 390236001037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236001038 Walker A motif; other site 390236001039 ATP binding site [chemical binding]; other site 390236001040 Walker B motif; other site 390236001041 arginine finger; other site 390236001042 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 390236001043 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 390236001044 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 390236001045 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 390236001046 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 390236001047 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 390236001048 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 390236001049 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 390236001050 trmE is a tRNA modification GTPase; Region: trmE; cd04164 390236001051 G1 box; other site 390236001052 GTP/Mg2+ binding site [chemical binding]; other site 390236001053 Switch I region; other site 390236001054 G2 box; other site 390236001055 Switch II region; other site 390236001056 G3 box; other site 390236001057 G4 box; other site 390236001058 G5 box; other site 390236001059 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 390236001060 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 390236001061 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 390236001062 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 390236001063 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 390236001064 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 390236001065 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 390236001066 flagellar assembly protein FliW; Provisional; Region: PRK13285 390236001067 carbon storage regulator (csrA); Region: csrA; TIGR00202 390236001068 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 390236001069 Glycoprotease family; Region: Peptidase_M22; pfam00814 390236001070 tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150 390236001071 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 390236001072 23S rRNA binding site [nucleotide binding]; other site 390236001073 L21 binding site [polypeptide binding]; other site 390236001074 L13 binding site [polypeptide binding]; other site 390236001075 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 390236001076 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 390236001077 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 390236001078 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 390236001079 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 390236001080 active site 390236001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001082 binding surface 390236001083 TPR motif; other site 390236001084 TPR repeat; Region: TPR_11; pfam13414 390236001085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001086 binding surface 390236001087 TPR motif; other site 390236001088 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 390236001089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001090 binding surface 390236001091 TPR motif; other site 390236001092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001093 binding surface 390236001094 TPR motif; other site 390236001095 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001096 peptide chain release factor 1; Validated; Region: prfA; PRK00591 390236001097 This domain is found in peptide chain release factors; Region: PCRF; smart00937 390236001098 RF-1 domain; Region: RF-1; pfam00472 390236001099 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 390236001100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390236001101 S-adenosylmethionine binding site [chemical binding]; other site 390236001102 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 390236001103 HD domain; Region: HD_4; pfam13328 390236001104 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 390236001105 synthetase active site [active] 390236001106 NTP binding site [chemical binding]; other site 390236001107 metal binding site [ion binding]; metal-binding site 390236001108 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 390236001109 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 390236001110 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 390236001111 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 390236001112 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 390236001113 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 390236001114 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390236001115 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390236001116 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 390236001117 Domain of unknown function DUF21; Region: DUF21; pfam01595 390236001118 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 390236001119 Transporter associated domain; Region: CorC_HlyC; smart01091 390236001120 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 390236001121 HflK protein; Region: hflK; TIGR01933 390236001122 HflC protein; Region: hflC; TIGR01932 390236001123 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 390236001124 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 390236001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390236001126 S-adenosylmethionine binding site [chemical binding]; other site 390236001127 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 390236001128 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 390236001129 active site 390236001130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001131 binding surface 390236001132 TPR motif; other site 390236001133 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001134 TPR repeat; Region: TPR_11; pfam13414 390236001135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001136 binding surface 390236001137 TPR repeat; Region: TPR_11; pfam13414 390236001138 TPR motif; other site 390236001139 TPR repeat; Region: TPR_11; pfam13414 390236001140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001141 binding surface 390236001142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001143 TPR motif; other site 390236001144 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 390236001145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001146 TPR motif; other site 390236001147 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001148 binding surface 390236001149 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 390236001150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236001151 Mg2+ binding site [ion binding]; other site 390236001152 G-X-G motif; other site 390236001153 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 390236001154 ATP binding site [chemical binding]; other site 390236001155 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 390236001156 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 390236001157 translation elongation factor P; Region: efp; TIGR00038 390236001158 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 390236001159 RNA binding site [nucleotide binding]; other site 390236001160 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 390236001161 RNA binding site [nucleotide binding]; other site 390236001162 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 390236001163 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 390236001164 PBP superfamily domain; Region: PBP_like_2; cl17296 390236001165 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 390236001166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236001167 dimer interface [polypeptide binding]; other site 390236001168 conserved gate region; other site 390236001169 putative PBP binding loops; other site 390236001170 ABC-ATPase subunit interface; other site 390236001171 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 390236001172 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 390236001173 Walker A/P-loop; other site 390236001174 ATP binding site [chemical binding]; other site 390236001175 Q-loop/lid; other site 390236001176 ABC transporter signature motif; other site 390236001177 Walker B; other site 390236001178 D-loop; other site 390236001179 H-loop/switch region; other site 390236001180 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 390236001181 ZIP Zinc transporter; Region: Zip; pfam02535 390236001182 alanyl-tRNA synthetase; Provisional; Region: PRK01584 390236001183 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 390236001184 motif 1; other site 390236001185 active site 390236001186 motif 2; other site 390236001187 motif 3; other site 390236001188 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 390236001189 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 390236001190 FliG C-terminal domain; Region: FliG_C; pfam01706 390236001191 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 390236001192 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 390236001193 putative active site [active] 390236001194 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 390236001195 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 390236001196 FMN binding site [chemical binding]; other site 390236001197 active site 390236001198 catalytic residues [active] 390236001199 substrate binding site [chemical binding]; other site 390236001200 seryl-tRNA synthetase; Region: serS; TIGR00414 390236001201 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 390236001202 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 390236001203 dimer interface [polypeptide binding]; other site 390236001204 active site 390236001205 motif 1; other site 390236001206 motif 2; other site 390236001207 motif 3; other site 390236001208 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 390236001209 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 390236001210 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 390236001211 Peptidase M16C associated; Region: M16C_assoc; pfam08367 390236001212 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 390236001213 transcription termination factor Rho; Region: rho; TIGR00767 390236001214 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 390236001215 RNA binding site [nucleotide binding]; other site 390236001216 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 390236001217 multimer interface [polypeptide binding]; other site 390236001218 Walker A motif; other site 390236001219 ATP binding site [chemical binding]; other site 390236001220 Walker B motif; other site 390236001221 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 390236001222 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 390236001223 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 390236001224 IHF dimer interface [polypeptide binding]; other site 390236001225 IHF - DNA interface [nucleotide binding]; other site 390236001226 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 390236001227 GTP-binding protein YchF; Reviewed; Region: PRK09601 390236001228 YchF GTPase; Region: YchF; cd01900 390236001229 G1 box; other site 390236001230 GTP/Mg2+ binding site [chemical binding]; other site 390236001231 Switch I region; other site 390236001232 G2 box; other site 390236001233 Switch II region; other site 390236001234 G3 box; other site 390236001235 G4 box; other site 390236001236 G5 box; other site 390236001237 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 390236001238 TPR repeat; Region: TPR_11; pfam13414 390236001239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001240 TPR motif; other site 390236001241 binding surface 390236001242 Uncharacterized conserved protein [Function unknown]; Region: COG3391 390236001243 Uncharacterized conserved protein [Function unknown]; Region: COG3391 390236001244 von Willebrand factor type A domain; Region: VWA_2; pfam13519 390236001245 metal ion-dependent adhesion site (MIDAS); other site 390236001246 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 390236001247 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 390236001248 putative active site [active] 390236001249 catalytic triad [active] 390236001250 putative dimer interface [polypeptide binding]; other site 390236001251 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 390236001252 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 390236001253 Substrate-binding site [chemical binding]; other site 390236001254 Substrate specificity [chemical binding]; other site 390236001255 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 390236001256 amphipathic channel; other site 390236001257 Asn-Pro-Ala signature motifs; other site 390236001258 glycerol kinase; Provisional; Region: glpK; PRK00047 390236001259 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 390236001260 N- and C-terminal domain interface [polypeptide binding]; other site 390236001261 active site 390236001262 MgATP binding site [chemical binding]; other site 390236001263 catalytic site [active] 390236001264 metal binding site [ion binding]; metal-binding site 390236001265 glycerol binding site [chemical binding]; other site 390236001266 homotetramer interface [polypeptide binding]; other site 390236001267 homodimer interface [polypeptide binding]; other site 390236001268 FBP binding site [chemical binding]; other site 390236001269 protein IIAGlc interface [polypeptide binding]; other site 390236001270 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 390236001271 Protein of unknown function (DUF327); Region: DUF327; cl00753 390236001272 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 390236001273 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 390236001274 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 390236001275 Peptidase family M23; Region: Peptidase_M23; pfam01551 390236001276 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 390236001277 active site 390236001278 dimerization interface [polypeptide binding]; other site 390236001279 oligoendopeptidase F; Region: pepF; TIGR00181 390236001280 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 390236001281 active site 390236001282 Zn binding site [ion binding]; other site 390236001283 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 390236001284 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 390236001285 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 390236001286 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 390236001287 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 390236001288 HIGH motif; other site 390236001289 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 390236001290 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390236001291 active site 390236001292 KMSKS motif; other site 390236001293 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 390236001294 tRNA binding surface [nucleotide binding]; other site 390236001295 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 390236001296 Found in ATP-dependent protease La (LON); Region: LON; smart00464 390236001297 ATP-dependent protease La; Region: lon; TIGR00763 390236001298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236001299 Walker A motif; other site 390236001300 ATP binding site [chemical binding]; other site 390236001301 Walker B motif; other site 390236001302 arginine finger; other site 390236001303 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 390236001304 DHH family; Region: DHH; pfam01368 390236001305 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 390236001306 DHHA1 domain; Region: DHHA1; pfam02272 390236001307 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 390236001308 Peptidase family M23; Region: Peptidase_M23; pfam01551 390236001309 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 390236001310 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 390236001311 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 390236001312 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 390236001313 Bacitracin resistance protein BacA; Region: BacA; cl00858 390236001314 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 390236001315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 390236001316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 390236001317 catalytic residue [active] 390236001318 TPR repeat; Region: TPR_11; pfam13414 390236001319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001320 TPR motif; other site 390236001321 binding surface 390236001322 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 390236001323 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236001324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236001325 Peptidase family M23; Region: Peptidase_M23; pfam01551 390236001326 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 390236001327 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 390236001328 Catalytic site [active] 390236001329 rod shape-determining protein MreB; Provisional; Region: PRK13930 390236001330 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 390236001331 nucleotide binding site [chemical binding]; other site 390236001332 putative NEF/HSP70 interaction site [polypeptide binding]; other site 390236001333 SBD interface [polypeptide binding]; other site 390236001334 Uncharacterized conserved protein [Function unknown]; Region: COG1315 390236001335 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 390236001336 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 390236001337 P-loop; other site 390236001338 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 390236001339 Protein of unknown function, DUF258; Region: DUF258; pfam03193 390236001340 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 390236001341 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 390236001342 FHIPEP family; Region: FHIPEP; pfam00771 390236001343 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 390236001344 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 390236001345 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 390236001346 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 390236001347 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 390236001348 flagellar biosynthesis protein FliZ; Provisional; Region: PRK13414 390236001349 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 390236001350 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 390236001351 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 390236001352 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK06654 390236001353 flagellar motor protein MotB; Validated; Region: motB; PRK06667 390236001354 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 390236001355 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 390236001356 ligand binding site [chemical binding]; other site 390236001357 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 390236001358 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 390236001359 Flagellar protein (FlbD); Region: FlbD; cl00683 390236001360 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 390236001361 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 390236001362 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 390236001363 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 390236001364 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 390236001365 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 390236001366 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 390236001367 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 390236001368 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 390236001369 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390236001370 Walker A motif; other site 390236001371 ATP binding site [chemical binding]; other site 390236001372 Walker B motif; other site 390236001373 flagellar assembly protein H; Validated; Region: fliH; PRK06669 390236001374 Flagellar assembly protein FliH; Region: FliH; pfam02108 390236001375 flagellar motor switch protein FliG; Region: fliG; TIGR00207 390236001376 FliG C-terminal domain; Region: FliG_C; pfam01706 390236001377 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 390236001378 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 390236001379 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 390236001380 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01482 390236001381 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 390236001382 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 390236001383 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 390236001384 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 390236001385 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 390236001386 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 390236001387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236001388 Walker A motif; other site 390236001389 ATP binding site [chemical binding]; other site 390236001390 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 390236001391 Walker B motif; other site 390236001392 arginine finger; other site 390236001393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 390236001394 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 390236001395 active site 390236001396 HslU subunit interaction site [polypeptide binding]; other site 390236001397 DNA protecting protein DprA; Region: dprA; TIGR00732 390236001398 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 390236001399 TPR repeat; Region: TPR_11; pfam13414 390236001400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001401 binding surface 390236001402 TPR motif; other site 390236001403 cell division protein FtsZ; Validated; Region: PRK09330 390236001404 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 390236001405 nucleotide binding site [chemical binding]; other site 390236001406 SulA interaction site; other site 390236001407 cell division protein FtsA; Region: ftsA; TIGR01174 390236001408 Cell division protein FtsA; Region: FtsA; smart00842 390236001409 Cell division protein FtsA; Region: FtsA; pfam14450 390236001410 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 390236001411 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 390236001412 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 390236001413 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 390236001414 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 390236001415 Mg++ binding site [ion binding]; other site 390236001416 putative catalytic motif [active] 390236001417 putative substrate binding site [chemical binding]; other site 390236001418 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 390236001419 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 390236001420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390236001421 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390236001422 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 390236001423 MraW methylase family; Region: Methyltransf_5; cl17771 390236001424 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 390236001425 ATP-NAD kinase; Region: NAD_kinase; pfam01513 390236001426 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 390236001427 putative CheA interaction surface; other site 390236001428 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 390236001429 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 390236001430 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 390236001431 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 390236001432 substrate binding pocket [chemical binding]; other site 390236001433 chain length determination region; other site 390236001434 substrate-Mg2+ binding site; other site 390236001435 catalytic residues [active] 390236001436 aspartate-rich region 1; other site 390236001437 active site lid residues [active] 390236001438 aspartate-rich region 2; other site 390236001439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 390236001440 binding surface 390236001441 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001442 TPR motif; other site 390236001443 Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079 390236001444 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 390236001445 TM-ABC transporter signature motif; other site 390236001446 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 390236001447 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 390236001448 Walker A/P-loop; other site 390236001449 ATP binding site [chemical binding]; other site 390236001450 Q-loop/lid; other site 390236001451 ABC transporter signature motif; other site 390236001452 Walker B; other site 390236001453 D-loop; other site 390236001454 H-loop/switch region; other site 390236001455 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390236001456 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 390236001457 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 390236001458 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001459 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 390236001460 metal ion-dependent adhesion site (MIDAS); other site 390236001461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 390236001462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001463 binding surface 390236001464 TPR motif; other site 390236001465 Phosphate acyltransferases; Region: PlsC; smart00563 390236001466 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390236001467 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390236001468 peptide binding site [polypeptide binding]; other site 390236001469 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390236001470 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390236001471 peptide binding site [polypeptide binding]; other site 390236001472 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390236001473 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390236001474 peptide binding site [polypeptide binding]; other site 390236001475 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 390236001476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236001477 dimer interface [polypeptide binding]; other site 390236001478 conserved gate region; other site 390236001479 putative PBP binding loops; other site 390236001480 ABC-ATPase subunit interface; other site 390236001481 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 390236001482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 390236001483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236001484 dimer interface [polypeptide binding]; other site 390236001485 conserved gate region; other site 390236001486 putative PBP binding loops; other site 390236001487 ABC-ATPase subunit interface; other site 390236001488 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 390236001489 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 390236001490 Walker A/P-loop; other site 390236001491 ATP binding site [chemical binding]; other site 390236001492 Q-loop/lid; other site 390236001493 ABC transporter signature motif; other site 390236001494 Walker B; other site 390236001495 D-loop; other site 390236001496 H-loop/switch region; other site 390236001497 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 390236001498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 390236001499 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 390236001500 Walker A/P-loop; other site 390236001501 ATP binding site [chemical binding]; other site 390236001502 Q-loop/lid; other site 390236001503 ABC transporter signature motif; other site 390236001504 Walker B; other site 390236001505 D-loop; other site 390236001506 H-loop/switch region; other site 390236001507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 390236001508 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 390236001509 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 390236001510 enolase; Provisional; Region: eno; PRK00077 390236001511 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 390236001512 dimer interface [polypeptide binding]; other site 390236001513 metal binding site [ion binding]; metal-binding site 390236001514 substrate binding pocket [chemical binding]; other site 390236001515 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 390236001516 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 390236001517 23S rRNA interface [nucleotide binding]; other site 390236001518 L3 interface [polypeptide binding]; other site 390236001519 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 390236001520 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 390236001521 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 390236001522 GatB domain; Region: GatB_Yqey; smart00845 390236001523 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 390236001524 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 390236001525 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 390236001526 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 390236001527 Part of AAA domain; Region: AAA_19; pfam13245 390236001528 Family description; Region: UvrD_C_2; pfam13538 390236001529 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 390236001530 Helix-turn-helix domain; Region: HTH_25; pfam13413 390236001531 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 390236001532 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 390236001533 Domain of unknown function (DUF814); Region: DUF814; pfam05670 390236001534 pyruvate kinase; Provisional; Region: PRK05826 390236001535 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 390236001536 domain interfaces; other site 390236001537 active site 390236001538 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 390236001539 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 390236001540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 390236001541 RNA methyltransferase, RsmE family; Region: TIGR00046 390236001542 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 390236001543 C-terminal peptidase (prc); Region: prc; TIGR00225 390236001544 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 390236001545 protein binding site [polypeptide binding]; other site 390236001546 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 390236001547 Catalytic dyad [active] 390236001548 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 390236001549 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 390236001550 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 390236001551 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 390236001552 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 390236001553 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 390236001554 active site 390236001555 dimer interfaces [polypeptide binding]; other site 390236001556 catalytic residues [active] 390236001557 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 390236001558 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 390236001559 oligomer interface [polypeptide binding]; other site 390236001560 putative active site [active] 390236001561 metal binding site [ion binding]; metal-binding site 390236001562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 390236001563 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 390236001564 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 390236001565 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 390236001566 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 390236001567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236001568 Walker A motif; other site 390236001569 ATP binding site [chemical binding]; other site 390236001570 Walker B motif; other site 390236001571 arginine finger; other site 390236001572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 390236001573 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 390236001574 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 390236001575 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 390236001576 active site 390236001577 HIGH motif; other site 390236001578 dimer interface [polypeptide binding]; other site 390236001579 KMSKS motif; other site 390236001580 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390236001581 RNA binding surface [nucleotide binding]; other site 390236001582 glycyl-tRNA synthetase; Provisional; Region: PRK04173 390236001583 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 390236001584 dimer interface [polypeptide binding]; other site 390236001585 motif 1; other site 390236001586 active site 390236001587 motif 2; other site 390236001588 motif 3; other site 390236001589 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 390236001590 anticodon binding site; other site 390236001591 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 390236001592 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 390236001593 active site 390236001594 HIGH motif; other site 390236001595 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 390236001596 active site 390236001597 KMSKS motif; other site 390236001598 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 390236001599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 390236001600 Zn2+ binding site [ion binding]; other site 390236001601 Mg2+ binding site [ion binding]; other site 390236001602 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 390236001603 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 390236001604 S-adenosylmethionine synthetase; Region: metK; TIGR01034 390236001605 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 390236001606 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 390236001607 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 390236001608 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 390236001609 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 390236001610 HIT family signature motif; other site 390236001611 catalytic residue [active] 390236001612 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 390236001613 MgtE intracellular N domain; Region: MgtE_N; pfam03448 390236001614 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 390236001615 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 390236001616 Divalent cation transporter; Region: MgtE; pfam01769 390236001617 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 390236001618 Trehalase; Region: Trehalase; cl17346 390236001619 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390236001620 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390236001621 ligand binding site [chemical binding]; other site 390236001622 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390236001623 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390236001624 ligand binding site [chemical binding]; other site 390236001625 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 390236001626 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390236001627 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390236001628 ligand binding site [chemical binding]; other site 390236001629 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390236001630 Basic membrane protein; Region: Bmp; pfam02608 390236001631 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 390236001632 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 390236001633 ligand binding site [chemical binding]; other site 390236001634 30S ribosomal protein S7; Validated; Region: PRK05302 390236001635 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 390236001636 S17 interaction site [polypeptide binding]; other site 390236001637 S8 interaction site; other site 390236001638 16S rRNA interaction site [nucleotide binding]; other site 390236001639 streptomycin interaction site [chemical binding]; other site 390236001640 23S rRNA interaction site [nucleotide binding]; other site 390236001641 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 390236001642 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 390236001643 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 390236001644 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 390236001645 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 390236001646 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 390236001647 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 390236001648 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 390236001649 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 390236001650 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 390236001651 cleft; other site 390236001652 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 390236001653 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 390236001654 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 390236001655 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 390236001656 DNA binding site [nucleotide binding] 390236001657 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 390236001658 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 390236001659 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 390236001660 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 390236001661 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 390236001662 RPB10 interaction site [polypeptide binding]; other site 390236001663 RPB1 interaction site [polypeptide binding]; other site 390236001664 RPB11 interaction site [polypeptide binding]; other site 390236001665 RPB3 interaction site [polypeptide binding]; other site 390236001666 RPB12 interaction site [polypeptide binding]; other site 390236001667 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 390236001668 core dimer interface [polypeptide binding]; other site 390236001669 peripheral dimer interface [polypeptide binding]; other site 390236001670 L10 interface [polypeptide binding]; other site 390236001671 L11 interface [polypeptide binding]; other site 390236001672 putative EF-Tu interaction site [polypeptide binding]; other site 390236001673 putative EF-G interaction site [polypeptide binding]; other site 390236001674 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 390236001675 23S rRNA interface [nucleotide binding]; other site 390236001676 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 390236001677 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 390236001678 mRNA/rRNA interface [nucleotide binding]; other site 390236001679 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 390236001680 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 390236001681 23S rRNA interface [nucleotide binding]; other site 390236001682 L7/L12 interface [polypeptide binding]; other site 390236001683 putative thiostrepton binding site; other site 390236001684 L25 interface [polypeptide binding]; other site 390236001685 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 390236001686 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 390236001687 putative homodimer interface [polypeptide binding]; other site 390236001688 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 390236001689 heterodimer interface [polypeptide binding]; other site 390236001690 homodimer interface [polypeptide binding]; other site 390236001691 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 390236001692 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 390236001693 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 390236001694 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 390236001695 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 390236001696 prolyl-tRNA synthetase; Provisional; Region: PRK08661 390236001697 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 390236001698 dimer interface [polypeptide binding]; other site 390236001699 motif 1; other site 390236001700 active site 390236001701 motif 2; other site 390236001702 motif 3; other site 390236001703 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 390236001704 anticodon binding site; other site 390236001705 zinc-binding site [ion binding]; other site 390236001706 Predicted secreted protein [Function unknown]; Region: COG5497 390236001707 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 390236001708 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 390236001709 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 390236001710 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 390236001711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 390236001712 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 390236001713 active site 390236001714 phosphorylation site [posttranslational modification] 390236001715 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 390236001716 active site 390236001717 P-loop; other site 390236001718 phosphorylation site [posttranslational modification] 390236001719 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 390236001720 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 390236001721 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 390236001722 active site 390236001723 substrate binding site [chemical binding]; other site 390236001724 Mg2+ binding site [ion binding]; other site 390236001725 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 390236001726 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 390236001727 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 390236001728 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 390236001729 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 390236001730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236001731 active site 390236001732 phosphorylation site [posttranslational modification] 390236001733 intermolecular recognition site; other site 390236001734 CheB methylesterase; Region: CheB_methylest; pfam01339 390236001735 TraB family; Region: TraB; cl12050 390236001736 adenylate kinase; Provisional; Region: PRK14526 390236001737 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 390236001738 AMP-binding site [chemical binding]; other site 390236001739 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 390236001740 Response regulator receiver domain; Region: Response_reg; pfam00072 390236001741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236001742 active site 390236001743 phosphorylation site [posttranslational modification] 390236001744 intermolecular recognition site; other site 390236001745 dimerization interface [polypeptide binding]; other site 390236001746 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 390236001747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 390236001748 metal binding site [ion binding]; metal-binding site 390236001749 active site 390236001750 I-site; other site 390236001751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 390236001752 substrate binding pocket [chemical binding]; other site 390236001753 membrane-bound complex binding site; other site 390236001754 hinge residues; other site 390236001755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 390236001756 dimer interface [polypeptide binding]; other site 390236001757 phosphorylation site [posttranslational modification] 390236001758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236001759 ATP binding site [chemical binding]; other site 390236001760 Mg2+ binding site [ion binding]; other site 390236001761 G-X-G motif; other site 390236001762 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 390236001763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236001764 active site 390236001765 phosphorylation site [posttranslational modification] 390236001766 intermolecular recognition site; other site 390236001767 dimerization interface [polypeptide binding]; other site 390236001768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390236001769 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 390236001770 active site 390236001771 motif I; other site 390236001772 motif II; other site 390236001773 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 390236001774 active site 390236001775 DNA binding site [nucleotide binding] 390236001776 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 390236001777 Predicted methyltransferases [General function prediction only]; Region: COG0313 390236001778 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 390236001779 putative SAM binding site [chemical binding]; other site 390236001780 putative homodimer interface [polypeptide binding]; other site 390236001781 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 390236001782 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 390236001783 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 390236001784 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236001785 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236001786 P-loop; other site 390236001787 Magnesium ion binding site [ion binding]; other site 390236001788 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236001789 Magnesium ion binding site [ion binding]; other site 390236001790 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 390236001791 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 390236001792 ParB-like nuclease domain; Region: ParB; smart00470 390236001793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 390236001794 DNA gyrase, A subunit; Region: gyrA; TIGR01063 390236001795 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 390236001796 CAP-like domain; other site 390236001797 active site 390236001798 primary dimer interface [polypeptide binding]; other site 390236001799 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390236001800 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390236001801 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390236001802 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390236001803 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 390236001804 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 390236001805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236001806 ATP binding site [chemical binding]; other site 390236001807 Mg2+ binding site [ion binding]; other site 390236001808 G-X-G motif; other site 390236001809 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 390236001810 anchoring element; other site 390236001811 dimer interface [polypeptide binding]; other site 390236001812 ATP binding site [chemical binding]; other site 390236001813 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 390236001814 active site 390236001815 putative metal-binding site [ion binding]; other site 390236001816 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 390236001817 DnaA N-terminal domain; Region: DnaA_N; pfam11638 390236001818 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 390236001819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236001820 Walker A motif; other site 390236001821 ATP binding site [chemical binding]; other site 390236001822 Walker B motif; other site 390236001823 arginine finger; other site 390236001824 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 390236001825 DnaA box-binding interface [nucleotide binding]; other site 390236001826 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 390236001827 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 390236001828 putative DNA binding surface [nucleotide binding]; other site 390236001829 dimer interface [polypeptide binding]; other site 390236001830 beta-clamp/clamp loader binding surface; other site 390236001831 beta-clamp/translesion DNA polymerase binding surface; other site 390236001832 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 390236001833 Ribonuclease P; Region: Ribonuclease_P; cl00457 390236001834 membrane protein insertase; Provisional; Region: PRK01318 390236001835 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 390236001836 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 390236001837 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 390236001838 G-X-X-G motif; other site 390236001839 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 390236001840 RxxxH motif; other site 390236001841 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 390236001842 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 390236001843 putative NAD(P) binding site [chemical binding]; other site 390236001844 active site 390236001845 putative substrate binding site [chemical binding]; other site 390236001846 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 390236001847 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 390236001848 active site 390236001849 intersubunit interface [polypeptide binding]; other site 390236001850 zinc binding site [ion binding]; other site 390236001851 Na+ binding site [ion binding]; other site 390236001852 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 390236001853 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 390236001854 dimer interface [polypeptide binding]; other site 390236001855 anticodon binding site; other site 390236001856 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 390236001857 homodimer interface [polypeptide binding]; other site 390236001858 motif 1; other site 390236001859 active site 390236001860 motif 2; other site 390236001861 GAD domain; Region: GAD; pfam02938 390236001862 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 390236001863 active site 390236001864 motif 3; other site 390236001865 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 390236001866 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 390236001867 Sexual stage antigen s48/45 domain; Region: s48_45; smart00970 390236001868 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 390236001869 active site 390236001870 phosphorylation site [posttranslational modification] 390236001871 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 390236001872 dimerization domain swap beta strand [polypeptide binding]; other site 390236001873 regulatory protein interface [polypeptide binding]; other site 390236001874 active site 390236001875 regulatory phosphorylation site [posttranslational modification]; other site 390236001876 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 390236001877 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 390236001878 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 390236001879 Chromate transporter; Region: Chromate_transp; cl17781 390236001880 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 390236001881 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 390236001882 Mechanosensitive ion channel; Region: MS_channel; pfam00924 390236001883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 390236001884 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 390236001885 putative ADP-binding pocket [chemical binding]; other site 390236001886 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 390236001887 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 390236001888 GIY-YIG motif/motif A; other site 390236001889 active site 390236001890 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 390236001891 catalytic site [active] 390236001892 putative DNA binding site [nucleotide binding]; other site 390236001893 metal binding site [ion binding]; metal-binding site 390236001894 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 390236001895 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 390236001896 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 390236001897 Interdomain contacts; other site 390236001898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236001899 binding surface 390236001900 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236001901 TPR motif; other site 390236001902 potential protein location (conserved hypothetical protein [Borrelia afzelii PKo]) that overlaps RNA (tRNA-S) 390236001903 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 390236001904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236001905 Walker A motif; other site 390236001906 ATP binding site [chemical binding]; other site 390236001907 Walker B motif; other site 390236001908 DNA polymerase III subunit delta'; Validated; Region: PRK08485 390236001909 arginine finger; other site 390236001910 hypothetical protein; Provisional; Region: PRK14629 390236001911 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 390236001912 active site 390236001913 multimer interface [polypeptide binding]; other site 390236001914 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 390236001915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 390236001916 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 390236001917 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 390236001918 Walker A/P-loop; other site 390236001919 ATP binding site [chemical binding]; other site 390236001920 Q-loop/lid; other site 390236001921 ABC transporter signature motif; other site 390236001922 Walker B; other site 390236001923 D-loop; other site 390236001924 H-loop/switch region; other site 390236001925 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 390236001926 uncharacterized protein, YfiH family; Region: TIGR00726 390236001927 Uncharacterized conserved protein [Function unknown]; Region: COG0327 390236001928 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 390236001929 signal peptidase II; Provisional; Region: lspA; PRK01574 390236001930 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 390236001931 active site 390236001932 metal binding site [ion binding]; metal-binding site 390236001933 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 390236001934 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 390236001935 hinge; other site 390236001936 active site 390236001937 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 390236001938 putative efflux protein, MATE family; Region: matE; TIGR00797 390236001939 elongation factor Tu; Reviewed; Region: PRK00049 390236001940 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 390236001941 G1 box; other site 390236001942 GEF interaction site [polypeptide binding]; other site 390236001943 GTP/Mg2+ binding site [chemical binding]; other site 390236001944 Switch I region; other site 390236001945 G2 box; other site 390236001946 G3 box; other site 390236001947 Switch II region; other site 390236001948 G4 box; other site 390236001949 G5 box; other site 390236001950 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 390236001951 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 390236001952 Antibiotic Binding Site [chemical binding]; other site 390236001953 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 390236001954 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 390236001955 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 390236001956 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 390236001957 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 390236001958 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 390236001959 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 390236001960 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 390236001961 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 390236001962 putative translocon binding site; other site 390236001963 protein-rRNA interface [nucleotide binding]; other site 390236001964 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 390236001965 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 390236001966 G-X-X-G motif; other site 390236001967 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 390236001968 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 390236001969 23S rRNA interface [nucleotide binding]; other site 390236001970 5S rRNA interface [nucleotide binding]; other site 390236001971 putative antibiotic binding site [chemical binding]; other site 390236001972 L25 interface [polypeptide binding]; other site 390236001973 L27 interface [polypeptide binding]; other site 390236001974 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 390236001975 23S rRNA interface [nucleotide binding]; other site 390236001976 putative translocon interaction site; other site 390236001977 signal recognition particle (SRP54) interaction site; other site 390236001978 L23 interface [polypeptide binding]; other site 390236001979 trigger factor interaction site; other site 390236001980 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 390236001981 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 390236001982 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 390236001983 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 390236001984 RNA binding site [nucleotide binding]; other site 390236001985 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 390236001986 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 390236001987 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 390236001988 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 390236001989 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 390236001990 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 390236001991 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 390236001992 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 390236001993 5S rRNA interface [nucleotide binding]; other site 390236001994 23S rRNA interface [nucleotide binding]; other site 390236001995 L5 interface [polypeptide binding]; other site 390236001996 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 390236001997 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 390236001998 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 390236001999 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cl00203 390236002000 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 390236002001 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 390236002002 SecY translocase; Region: SecY; pfam00344 390236002003 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 390236002004 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 390236002005 30S ribosomal protein S13; Region: bact_S13; TIGR03631 390236002006 30S ribosomal protein S11; Validated; Region: PRK05309 390236002007 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 390236002008 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 390236002009 alphaNTD homodimer interface [polypeptide binding]; other site 390236002010 alphaNTD - beta interaction site [polypeptide binding]; other site 390236002011 alphaNTD - beta' interaction site [polypeptide binding]; other site 390236002012 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 390236002013 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 390236002014 phosphodiesterase; Provisional; Region: PRK12704 390236002015 KH domain; Region: KH_1; pfam00013 390236002016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 390236002017 Zn2+ binding site [ion binding]; other site 390236002018 Mg2+ binding site [ion binding]; other site 390236002019 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 390236002020 active site 390236002021 metal binding site [ion binding]; metal-binding site 390236002022 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 390236002023 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 390236002024 Spore germination protein [General function prediction only]; Region: COG5401 390236002025 Sporulation and spore germination; Region: Germane; smart00909 390236002026 GTP-binding protein Der; Reviewed; Region: PRK00093 390236002027 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 390236002028 G1 box; other site 390236002029 GTP/Mg2+ binding site [chemical binding]; other site 390236002030 Switch I region; other site 390236002031 G2 box; other site 390236002032 Switch II region; other site 390236002033 G3 box; other site 390236002034 G4 box; other site 390236002035 G5 box; other site 390236002036 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 390236002037 G1 box; other site 390236002038 GTP/Mg2+ binding site [chemical binding]; other site 390236002039 Switch I region; other site 390236002040 G2 box; other site 390236002041 G3 box; other site 390236002042 Switch II region; other site 390236002043 G4 box; other site 390236002044 G5 box; other site 390236002045 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 390236002046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390236002047 motif II; other site 390236002048 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 390236002049 AAA domain; Region: AAA_13; pfam13166 390236002050 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 390236002051 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 390236002052 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 390236002053 dimer interface [polypeptide binding]; other site 390236002054 motif 1; other site 390236002055 active site 390236002056 motif 2; other site 390236002057 motif 3; other site 390236002058 phenylalanyl-tRNA synthetase, beta subunit; Region: pheT_arch; TIGR00471 390236002059 tRNA synthetase B5 domain; Region: B5; pfam03484 390236002060 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 390236002061 dimer interface [polypeptide binding]; other site 390236002062 motif 1; other site 390236002063 motif 3; other site 390236002064 motif 2; other site 390236002065 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 390236002066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 390236002067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 390236002068 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 390236002069 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 390236002070 chaperone protein DnaJ; Provisional; Region: PRK14285 390236002071 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 390236002072 HSP70 interaction site [polypeptide binding]; other site 390236002073 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 390236002074 Zn binding sites [ion binding]; other site 390236002075 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 390236002076 dimer interface [polypeptide binding]; other site 390236002077 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 390236002078 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 390236002079 nucleotide binding site [chemical binding]; other site 390236002080 NEF interaction site [polypeptide binding]; other site 390236002081 SBD interface [polypeptide binding]; other site 390236002082 GrpE; Region: GrpE; pfam01025 390236002083 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 390236002084 dimer interface [polypeptide binding]; other site 390236002085 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 390236002086 NAD synthetase; Provisional; Region: PRK13981 390236002087 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 390236002088 active site 390236002089 catalytic triad [active] 390236002090 dimer interface [polypeptide binding]; other site 390236002091 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 390236002092 homodimer interface [polypeptide binding]; other site 390236002093 NAD binding pocket [chemical binding]; other site 390236002094 ATP binding pocket [chemical binding]; other site 390236002095 Mg binding site [ion binding]; other site 390236002096 active-site loop [active] 390236002097 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 390236002098 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 390236002099 active site 390236002100 pantothenate kinase; Reviewed; Region: PRK13326 390236002101 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 390236002102 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 390236002103 active site 390236002104 catalytic tetrad [active] 390236002105 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 390236002106 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 390236002107 putative hydrolase; Provisional; Region: PRK02113 390236002108 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 390236002109 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 390236002110 active site 390236002111 putative catalytic site [active] 390236002112 phosphate binding site A [ion binding]; other site 390236002113 DNA binding site [nucleotide binding] 390236002114 metal binding site A [ion binding]; metal-binding site 390236002115 putative AP binding site [nucleotide binding]; other site 390236002116 putative metal binding site B [ion binding]; other site 390236002117 phosphate binding site B [ion binding]; other site 390236002118 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 390236002119 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 390236002120 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 390236002121 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 390236002122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236002123 binding surface 390236002124 TPR motif; other site 390236002125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236002126 binding surface 390236002127 Tetratricopeptide repeat; Region: TPR_16; pfam13432 390236002128 TPR motif; other site 390236002129 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 390236002130 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 390236002131 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 390236002132 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 390236002133 translation elongation factor EF-G; Region: EF-G; TIGR00484 390236002134 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 390236002135 G1 box; other site 390236002136 putative GEF interaction site [polypeptide binding]; other site 390236002137 GTP/Mg2+ binding site [chemical binding]; other site 390236002138 Switch I region; other site 390236002139 G2 box; other site 390236002140 G3 box; other site 390236002141 Switch II region; other site 390236002142 G4 box; other site 390236002143 G5 box; other site 390236002144 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 390236002145 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 390236002146 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 390236002147 KTSC domain; Region: KTSC; pfam13619 390236002148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236002149 binding surface 390236002150 TPR motif; other site 390236002151 TPR repeat; Region: TPR_11; pfam13414 390236002152 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 390236002153 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 390236002154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390236002155 active site 390236002156 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 390236002157 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 390236002158 nucleotide binding site [chemical binding]; other site 390236002159 Sporulation related domain; Region: SPOR; pfam05036 390236002160 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 390236002161 CoA-binding site [chemical binding]; other site 390236002162 ATP-binding [chemical binding]; other site 390236002163 DNA polymerase I; Region: pola; TIGR00593 390236002164 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 390236002165 active site 390236002166 putative 5' ssDNA interaction site; other site 390236002167 metal binding site 3; metal-binding site 390236002168 metal binding site 1 [ion binding]; metal-binding site 390236002169 metal binding site 2 [ion binding]; metal-binding site 390236002170 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 390236002171 putative DNA binding site [nucleotide binding]; other site 390236002172 putative metal binding site [ion binding]; other site 390236002173 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 390236002174 active site 390236002175 catalytic site [active] 390236002176 substrate binding site [chemical binding]; other site 390236002177 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 390236002178 active site 390236002179 DNA binding site [nucleotide binding] 390236002180 catalytic site [active] 390236002181 Flagellar protein FliS; Region: FliS; cl00654 390236002182 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 390236002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236002184 active site 390236002185 phosphorylation site [posttranslational modification] 390236002186 intermolecular recognition site; other site 390236002187 dimerization interface [polypeptide binding]; other site 390236002188 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 390236002189 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 390236002190 nucleotide binding pocket [chemical binding]; other site 390236002191 K-X-D-G motif; other site 390236002192 catalytic site [active] 390236002193 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 390236002194 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 390236002195 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 390236002196 Dimer interface [polypeptide binding]; other site 390236002197 BRCT sequence motif; other site 390236002198 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 390236002199 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 390236002200 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 390236002201 dimerization domain swap beta strand [polypeptide binding]; other site 390236002202 regulatory protein interface [polypeptide binding]; other site 390236002203 active site 390236002204 regulatory phosphorylation site [posttranslational modification]; other site 390236002205 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 390236002206 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 390236002207 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 390236002208 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 390236002209 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 390236002210 HPr interaction site; other site 390236002211 glycerol kinase (GK) interaction site [polypeptide binding]; other site 390236002212 active site 390236002213 phosphorylation site [posttranslational modification] 390236002214 heat shock protein 90; Provisional; Region: PRK05218 390236002215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236002216 ATP binding site [chemical binding]; other site 390236002217 Mg2+ binding site [ion binding]; other site 390236002218 G-X-G motif; other site 390236002219 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 390236002220 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 390236002221 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 390236002222 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 390236002223 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 390236002224 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 390236002225 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 390236002226 putative CheA interaction surface; other site 390236002227 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 390236002228 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 390236002229 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 390236002230 putative binding surface; other site 390236002231 active site 390236002232 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 390236002233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236002234 ATP binding site [chemical binding]; other site 390236002235 Mg2+ binding site [ion binding]; other site 390236002236 G-X-G motif; other site 390236002237 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 390236002238 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 390236002239 CheB methylesterase; Region: CheB_methylest; pfam01339 390236002240 Response regulator receiver domain; Region: Response_reg; pfam00072 390236002241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236002242 active site 390236002243 phosphorylation site [posttranslational modification] 390236002244 intermolecular recognition site; other site 390236002245 dimerization interface [polypeptide binding]; other site 390236002246 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 390236002247 nucleotide binding site [chemical binding]; other site 390236002248 homodimeric interface [polypeptide binding]; other site 390236002249 uridine monophosphate binding site [chemical binding]; other site 390236002250 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 390236002251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 390236002252 active site 390236002253 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 390236002254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236002255 Walker A/P-loop; other site 390236002256 ATP binding site [chemical binding]; other site 390236002257 Q-loop/lid; other site 390236002258 ABC transporter signature motif; other site 390236002259 Walker B; other site 390236002260 D-loop; other site 390236002261 H-loop/switch region; other site 390236002262 CTP synthase; Region: PyrG; TIGR00337 390236002263 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 390236002264 Catalytic site [active] 390236002265 active site 390236002266 UTP binding site [chemical binding]; other site 390236002267 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 390236002268 active site 390236002269 putative oxyanion hole; other site 390236002270 catalytic triad [active] 390236002271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 390236002272 putative CheW interface [polypeptide binding]; other site 390236002273 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 390236002274 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 390236002275 active site 390236002276 PHP Thumb interface [polypeptide binding]; other site 390236002277 metal binding site [ion binding]; metal-binding site 390236002278 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 390236002279 generic binding surface I; other site 390236002280 generic binding surface II; other site 390236002281 YGGT family; Region: YGGT; pfam02325 390236002282 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 390236002283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390236002284 ATP binding site [chemical binding]; other site 390236002285 putative Mg++ binding site [ion binding]; other site 390236002286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390236002287 nucleotide binding region [chemical binding]; other site 390236002288 ATP-binding site [chemical binding]; other site 390236002289 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 390236002290 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 390236002291 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 390236002292 putative efflux protein, MATE family; Region: matE; TIGR00797 390236002293 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 390236002294 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 390236002295 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 390236002296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390236002297 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 390236002298 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 390236002299 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 390236002300 active site 390236002301 HIGH motif; other site 390236002302 KMSKS motif; other site 390236002303 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 390236002304 tRNA binding surface [nucleotide binding]; other site 390236002305 anticodon binding site; other site 390236002306 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 390236002307 putative tRNA-binding site [nucleotide binding]; other site 390236002308 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 390236002309 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 390236002310 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 390236002311 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 390236002312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 390236002313 S-adenosylmethionine binding site [chemical binding]; other site 390236002314 Competence protein; Region: Competence; cl00471 390236002315 CAAX protease self-immunity; Region: Abi; pfam02517 390236002316 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 390236002317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 390236002318 acyl-activating enzyme (AAE) consensus motif; other site 390236002319 AMP binding site [chemical binding]; other site 390236002320 active site 390236002321 CoA binding site [chemical binding]; other site 390236002322 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 390236002323 arginyl-tRNA synthetase; Region: argS; TIGR00456 390236002324 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 390236002325 active site 390236002326 HIGH motif; other site 390236002327 KMSK motif region; other site 390236002328 tRNA binding surface [nucleotide binding]; other site 390236002329 DALR anticodon binding domain; Region: DALR_1; smart00836 390236002330 anticodon binding site; other site 390236002331 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 390236002332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 390236002333 dimer interface [polypeptide binding]; other site 390236002334 putative CheW interface [polypeptide binding]; other site 390236002335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 390236002336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 390236002337 putative CheW interface [polypeptide binding]; other site 390236002338 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 390236002339 FAD binding domain; Region: FAD_binding_4; pfam01565 390236002340 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 390236002341 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14534 390236002342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390236002343 active site 390236002344 HIGH motif; other site 390236002345 nucleotide binding site [chemical binding]; other site 390236002346 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 390236002347 KMSKS motif; other site 390236002348 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 390236002349 tRNA binding surface [nucleotide binding]; other site 390236002350 anticodon binding site; other site 390236002351 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 390236002352 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 390236002353 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 390236002354 dimer interface [polypeptide binding]; other site 390236002355 active site 390236002356 glycine-pyridoxal phosphate binding site [chemical binding]; other site 390236002357 folate binding site [chemical binding]; other site 390236002358 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 390236002359 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 390236002360 HSP70 interaction site [polypeptide binding]; other site 390236002361 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 390236002362 L-lactate permease; Region: Lactate_perm; cl00701 390236002363 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 390236002364 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 390236002365 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 390236002366 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 390236002367 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13494 390236002368 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 390236002369 Part of AAA domain; Region: AAA_19; pfam13245 390236002370 Family description; Region: UvrD_C_2; pfam13538 390236002371 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 390236002372 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 390236002373 metal binding site [ion binding]; metal-binding site 390236002374 dimer interface [polypeptide binding]; other site 390236002375 trigger factor; Provisional; Region: tig; PRK01490 390236002376 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 390236002377 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 390236002378 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 390236002379 oligomer interface [polypeptide binding]; other site 390236002380 active site residues [active] 390236002381 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 390236002382 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 390236002383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236002384 Walker A motif; other site 390236002385 ATP binding site [chemical binding]; other site 390236002386 Walker B motif; other site 390236002387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 390236002388 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 390236002389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236002390 Walker A motif; other site 390236002391 ATP binding site [chemical binding]; other site 390236002392 Walker B motif; other site 390236002393 arginine finger; other site 390236002394 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 390236002395 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 390236002396 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 390236002397 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 390236002398 RNA binding surface [nucleotide binding]; other site 390236002399 Predicted acetyltransferase [General function prediction only]; Region: COG2388 390236002400 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 390236002401 Cation efflux family; Region: Cation_efflux; pfam01545 390236002402 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 390236002403 active site 390236002404 catalytic motif [active] 390236002405 Zn binding site [ion binding]; other site 390236002406 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 390236002407 DHH family; Region: DHH; pfam01368 390236002408 DHHA1 domain; Region: DHHA1; pfam02272 390236002409 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 390236002410 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 390236002411 DJ-1 family protein; Region: not_thiJ; TIGR01383 390236002412 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 390236002413 conserved cys residue [active] 390236002414 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 390236002415 propionate/acetate kinase; Provisional; Region: PRK12379 390236002416 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 390236002417 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 390236002418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390236002419 ATP binding site [chemical binding]; other site 390236002420 putative Mg++ binding site [ion binding]; other site 390236002421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390236002422 nucleotide binding region [chemical binding]; other site 390236002423 ATP-binding site [chemical binding]; other site 390236002424 TRCF domain; Region: TRCF; pfam03461 390236002425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236002426 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236002427 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236002428 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236002429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236002430 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 390236002431 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 390236002432 active site 390236002433 metal binding site [ion binding]; metal-binding site 390236002434 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 390236002435 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 390236002436 putative active site [active] 390236002437 putative metal binding site [ion binding]; other site 390236002438 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 390236002439 M18 Peptidase aminopeptidase family; Region: M18; cd05639 390236002440 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 390236002441 active site 390236002442 metal binding site [ion binding]; metal-binding site 390236002443 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 390236002444 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 390236002445 active site 390236002446 phosphorylation site [posttranslational modification] 390236002447 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 390236002448 active site 390236002449 P-loop; other site 390236002450 phosphorylation site [posttranslational modification] 390236002451 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 390236002452 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 390236002453 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 390236002454 putative substrate binding site [chemical binding]; other site 390236002455 putative ATP binding site [chemical binding]; other site 390236002456 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 390236002457 AAA domain; Region: AAA_30; pfam13604 390236002458 Family description; Region: UvrD_C_2; pfam13538 390236002459 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 390236002460 Part of AAA domain; Region: AAA_19; pfam13245 390236002461 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 390236002462 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 390236002463 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 390236002464 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 390236002465 active site 390236002466 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 390236002467 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 390236002468 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 390236002469 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 390236002470 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 390236002471 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 390236002472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 390236002473 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 390236002474 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 390236002475 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 390236002476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236002477 dimer interface [polypeptide binding]; other site 390236002478 conserved gate region; other site 390236002479 putative PBP binding loops; other site 390236002480 ABC-ATPase subunit interface; other site 390236002481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236002482 dimer interface [polypeptide binding]; other site 390236002483 conserved gate region; other site 390236002484 putative PBP binding loops; other site 390236002485 ABC-ATPase subunit interface; other site 390236002486 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 390236002487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236002488 Walker A/P-loop; other site 390236002489 ATP binding site [chemical binding]; other site 390236002490 Q-loop/lid; other site 390236002491 ABC transporter signature motif; other site 390236002492 Walker B; other site 390236002493 D-loop; other site 390236002494 H-loop/switch region; other site 390236002495 TOBE domain; Region: TOBE_2; pfam08402 390236002496 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 390236002497 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 390236002498 GTP/Mg2+ binding site [chemical binding]; other site 390236002499 G4 box; other site 390236002500 G5 box; other site 390236002501 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 390236002502 G1 box; other site 390236002503 G1 box; other site 390236002504 GTP/Mg2+ binding site [chemical binding]; other site 390236002505 Switch I region; other site 390236002506 G2 box; other site 390236002507 G2 box; other site 390236002508 Switch I region; other site 390236002509 G3 box; other site 390236002510 G3 box; other site 390236002511 Switch II region; other site 390236002512 Switch II region; other site 390236002513 G4 box; other site 390236002514 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 390236002515 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 390236002516 putative active site cavity [active] 390236002517 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 390236002518 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 390236002519 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 390236002520 active site turn [active] 390236002521 phosphorylation site [posttranslational modification] 390236002522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 390236002523 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 390236002524 metal binding site 2 [ion binding]; metal-binding site 390236002525 putative DNA binding helix; other site 390236002526 metal binding site 1 [ion binding]; metal-binding site 390236002527 structural Zn2+ binding site [ion binding]; other site 390236002528 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 390236002529 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 390236002530 ring oligomerisation interface [polypeptide binding]; other site 390236002531 ATP/Mg binding site [chemical binding]; other site 390236002532 stacking interactions; other site 390236002533 hinge regions; other site 390236002534 Preprotein translocase subunit; Region: YajC; cl00806 390236002535 protein-export membrane protein SecD; Region: secD; TIGR01129 390236002536 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 390236002537 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 390236002538 Protein export membrane protein; Region: SecD_SecF; pfam02355 390236002539 chaperone protein DnaJ; Provisional; Region: PRK14299 390236002540 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 390236002541 HSP70 interaction site [polypeptide binding]; other site 390236002542 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 390236002543 substrate binding site [polypeptide binding]; other site 390236002544 dimer interface [polypeptide binding]; other site 390236002545 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 390236002546 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 390236002547 tetramer (dimer of dimers) interface [polypeptide binding]; other site 390236002548 active site 390236002549 dimer interface [polypeptide binding]; other site 390236002550 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390236002551 catalytic core [active] 390236002552 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 390236002553 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 390236002554 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 390236002555 active site 390236002556 HIGH motif; other site 390236002557 KMSKS motif; other site 390236002558 GTPase Era; Reviewed; Region: era; PRK00089 390236002559 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 390236002560 G1 box; other site 390236002561 GTP/Mg2+ binding site [chemical binding]; other site 390236002562 Switch I region; other site 390236002563 G2 box; other site 390236002564 Switch II region; other site 390236002565 G3 box; other site 390236002566 G4 box; other site 390236002567 G5 box; other site 390236002568 KH domain; Region: KH_2; pfam07650 390236002569 Double zinc ribbon; Region: DZR; pfam12773 390236002570 Uncharacterized conserved protein [Function unknown]; Region: COG1430 390236002571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 390236002572 active site 390236002573 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 390236002574 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 390236002575 active site 390236002576 metal binding site [ion binding]; metal-binding site 390236002577 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 390236002578 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 390236002579 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 390236002580 putative binding surface; other site 390236002581 active site 390236002582 P2 response regulator binding domain; Region: P2; pfam07194 390236002583 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 390236002584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236002585 ATP binding site [chemical binding]; other site 390236002586 G-X-G motif; other site 390236002587 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 390236002588 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 390236002589 putative CheA interaction surface; other site 390236002590 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 390236002591 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 390236002592 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 390236002593 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 390236002594 Response regulator receiver domain; Region: Response_reg; pfam00072 390236002595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236002596 active site 390236002597 phosphorylation site [posttranslational modification] 390236002598 intermolecular recognition site; other site 390236002599 dimerization interface [polypeptide binding]; other site 390236002600 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 390236002601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 390236002602 motif II; other site 390236002603 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 390236002604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 390236002605 Walker A/P-loop; other site 390236002606 ATP binding site [chemical binding]; other site 390236002607 Q-loop/lid; other site 390236002608 ABC transporter signature motif; other site 390236002609 Walker B; other site 390236002610 D-loop; other site 390236002611 H-loop/switch region; other site 390236002612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236002613 Walker A/P-loop; other site 390236002614 ATP binding site [chemical binding]; other site 390236002615 Q-loop/lid; other site 390236002616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236002617 ABC transporter signature motif; other site 390236002618 Walker B; other site 390236002619 D-loop; other site 390236002620 H-loop/switch region; other site 390236002621 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 390236002622 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 390236002623 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 390236002624 TM-ABC transporter signature motif; other site 390236002625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 390236002626 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 390236002627 TM-ABC transporter signature motif; other site 390236002628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 390236002629 dimer interface [polypeptide binding]; other site 390236002630 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 390236002631 putative CheW interface [polypeptide binding]; other site 390236002632 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 390236002633 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 390236002634 dimer interface [polypeptide binding]; other site 390236002635 putative CheW interface [polypeptide binding]; other site 390236002636 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 390236002637 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 390236002638 Ligand Binding Site [chemical binding]; other site 390236002639 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 390236002640 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 390236002641 dimer interface [polypeptide binding]; other site 390236002642 active site 390236002643 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 390236002644 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 390236002645 homotetramer interface [polypeptide binding]; other site 390236002646 FMN binding site [chemical binding]; other site 390236002647 homodimer contacts [polypeptide binding]; other site 390236002648 putative active site [active] 390236002649 putative substrate binding site [chemical binding]; other site 390236002650 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 390236002651 homodimer interface [polypeptide binding]; other site 390236002652 catalytic residues [active] 390236002653 NAD binding site [chemical binding]; other site 390236002654 substrate binding pocket [chemical binding]; other site 390236002655 flexible flap; other site 390236002656 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 390236002657 diphosphomevalonate decarboxylase; Region: PLN02407 390236002658 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 390236002659 mevalonate kinase; Region: mevalon_kin; TIGR00549 390236002660 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 390236002661 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 390236002662 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 390236002663 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 390236002664 dimerization interface [polypeptide binding]; other site 390236002665 DPS ferroxidase diiron center [ion binding]; other site 390236002666 ion pore; other site 390236002667 elongation factor G; Reviewed; Region: PRK13351 390236002668 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 390236002669 G1 box; other site 390236002670 putative GEF interaction site [polypeptide binding]; other site 390236002671 GTP/Mg2+ binding site [chemical binding]; other site 390236002672 Switch I region; other site 390236002673 G2 box; other site 390236002674 G3 box; other site 390236002675 Switch II region; other site 390236002676 G4 box; other site 390236002677 G5 box; other site 390236002678 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 390236002679 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 390236002680 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 390236002681 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 390236002682 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 390236002683 signal recognition particle protein; Provisional; Region: PRK10867 390236002684 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 390236002685 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 390236002686 P loop; other site 390236002687 GTP binding site [chemical binding]; other site 390236002688 Signal peptide binding domain; Region: SRP_SPB; pfam02978 390236002689 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 390236002690 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 390236002691 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 390236002692 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 390236002693 RimM N-terminal domain; Region: RimM; pfam01782 390236002694 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 390236002695 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 390236002696 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 390236002697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390236002698 active site 390236002699 nucleotide binding site [chemical binding]; other site 390236002700 HIGH motif; other site 390236002701 KMSKS motif; other site 390236002702 acyl carrier protein; Provisional; Region: acpP; PRK00982 390236002703 ribonuclease III; Reviewed; Region: rnc; PRK00102 390236002704 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 390236002705 dimerization interface [polypeptide binding]; other site 390236002706 active site 390236002707 metal binding site [ion binding]; metal-binding site 390236002708 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 390236002709 dsRNA binding site [nucleotide binding]; other site 390236002710 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 390236002711 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 390236002712 active site 390236002713 NTP binding site [chemical binding]; other site 390236002714 metal binding triad [ion binding]; metal-binding site 390236002715 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 390236002716 conserved hypothetical protein, YceG family; Region: TIGR00247 390236002717 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 390236002718 dimerization interface [polypeptide binding]; other site 390236002719 CHC2 zinc finger; Region: zf-CHC2; pfam01807 390236002720 DNA primase, catalytic core; Region: dnaG; TIGR01391 390236002721 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 390236002722 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 390236002723 active site 390236002724 metal binding site [ion binding]; metal-binding site 390236002725 interdomain interaction site; other site 390236002726 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 390236002727 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 390236002728 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 390236002729 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 390236002730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 390236002731 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 390236002732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 390236002733 DNA binding residues [nucleotide binding] 390236002734 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 390236002735 Putative zinc ribbon domain; Region: DUF164; pfam02591 390236002736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 390236002737 binding surface 390236002738 TPR repeat; Region: TPR_11; pfam13414 390236002739 TPR motif; other site 390236002740 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 390236002741 MreB and similar proteins; Region: MreB_like; cd10225 390236002742 nucleotide binding site [chemical binding]; other site 390236002743 Mg binding site [ion binding]; other site 390236002744 putative protofilament interaction site [polypeptide binding]; other site 390236002745 RodZ interaction site [polypeptide binding]; other site 390236002746 rod shape-determining protein MreC; Region: mreC; TIGR00219 390236002747 rod shape-determining protein MreC; Region: MreC; pfam04085 390236002748 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 390236002749 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 390236002750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 390236002751 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 390236002752 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 390236002753 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 390236002754 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 390236002755 active site 390236002756 dimer interface [polypeptide binding]; other site 390236002757 motif 1; other site 390236002758 motif 2; other site 390236002759 motif 3; other site 390236002760 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 390236002761 anticodon binding site; other site 390236002762 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 390236002763 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 390236002764 putative active site [active] 390236002765 putative metal binding residues [ion binding]; other site 390236002766 signature motif; other site 390236002767 putative triphosphate binding site [ion binding]; other site 390236002768 dimer interface [polypeptide binding]; other site 390236002769 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 390236002770 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 390236002771 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 390236002772 TrkA-N domain; Region: TrkA_N; pfam02254 390236002773 TrkA-C domain; Region: TrkA_C; pfam02080 390236002774 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 390236002775 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 390236002776 P-loop; other site 390236002777 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 390236002778 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 390236002779 active site 390236002780 ADP/pyrophosphate binding site [chemical binding]; other site 390236002781 dimerization interface [polypeptide binding]; other site 390236002782 allosteric effector site; other site 390236002783 fructose-1,6-bisphosphate binding site; other site 390236002784 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 390236002785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 390236002786 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 390236002787 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 390236002788 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 390236002789 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 390236002790 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 390236002791 active site 390236002792 dimer interface [polypeptide binding]; other site 390236002793 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 390236002794 dimer interface [polypeptide binding]; other site 390236002795 active site 390236002796 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 390236002797 ParB-like nuclease domain; Region: ParB; smart00470 390236002798 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 390236002799 Transglycosylase; Region: Transgly; pfam00912 390236002800 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 390236002801 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 390236002802 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 390236002803 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 390236002804 rare lipoprotein A; Region: rlpA; TIGR00413 390236002805 Sporulation related domain; Region: SPOR; pfam05036 390236002806 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 390236002807 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 390236002808 FMN binding site [chemical binding]; other site 390236002809 active site 390236002810 catalytic residues [active] 390236002811 substrate binding site [chemical binding]; other site 390236002812 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 390236002813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 390236002814 active site 390236002815 HIGH motif; other site 390236002816 nucleotide binding site [chemical binding]; other site 390236002817 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 390236002818 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 390236002819 active site 390236002820 KMSKS motif; other site 390236002821 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 390236002822 tRNA binding surface [nucleotide binding]; other site 390236002823 anticodon binding site; other site 390236002824 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 390236002825 Uncharacterized conserved protein [Function unknown]; Region: COG4121 390236002826 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 390236002827 oligomerisation interface [polypeptide binding]; other site 390236002828 mobile loop; other site 390236002829 roof hairpin; other site 390236002830 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 390236002831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236002832 Walker A/P-loop; other site 390236002833 ATP binding site [chemical binding]; other site 390236002834 Q-loop/lid; other site 390236002835 ABC transporter signature motif; other site 390236002836 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390236002837 Walker B; other site 390236002838 D-loop; other site 390236002839 H-loop/switch region; other site 390236002840 ABC transporter; Region: ABC_tran_2; pfam12848 390236002841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 390236002842 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 390236002843 active site 390236002844 FOG: WD40-like repeat [Function unknown]; Region: COG1520 390236002845 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 390236002846 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 390236002847 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 390236002848 minor groove reading motif; other site 390236002849 helix-hairpin-helix signature motif; other site 390236002850 substrate binding pocket [chemical binding]; other site 390236002851 active site 390236002852 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 390236002853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236002854 ABC-ATPase subunit interface; other site 390236002855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 390236002856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 390236002857 ABC-ATPase subunit interface; other site 390236002858 putative PBP binding loops; other site 390236002859 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 390236002860 Septum formation initiator; Region: DivIC; pfam04977 390236002861 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 390236002862 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 390236002863 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 390236002864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 390236002865 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 390236002866 Walker A/P-loop; other site 390236002867 ATP binding site [chemical binding]; other site 390236002868 Q-loop/lid; other site 390236002869 ABC transporter signature motif; other site 390236002870 Walker B; other site 390236002871 D-loop; other site 390236002872 H-loop/switch region; other site 390236002873 ribonuclease Z; Region: RNase_Z; TIGR02651 390236002874 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 390236002875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 390236002876 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 390236002877 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 390236002878 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 390236002879 oligomer interface [polypeptide binding]; other site 390236002880 active site residues [active] 390236002881 Domain of unknown function (DUF368); Region: DUF368; cl00893 390236002882 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 390236002883 putative metal binding site [ion binding]; other site 390236002884 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 390236002885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 390236002886 Peptidase family M23; Region: Peptidase_M23; pfam01551 390236002887 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 390236002888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 390236002889 active site 390236002890 phosphorylation site [posttranslational modification] 390236002891 intermolecular recognition site; other site 390236002892 dimerization interface [polypeptide binding]; other site 390236002893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236002894 Walker A motif; other site 390236002895 ATP binding site [chemical binding]; other site 390236002896 Walker B motif; other site 390236002897 arginine finger; other site 390236002898 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 390236002899 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 390236002900 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 390236002901 dimer interface [polypeptide binding]; other site 390236002902 phosphorylation site [posttranslational modification] 390236002903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 390236002904 ATP binding site [chemical binding]; other site 390236002905 Mg2+ binding site [ion binding]; other site 390236002906 G-X-G motif; other site 390236002907 DNA polymerase III subunit delta'; Validated; Region: PRK08485 390236002908 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 390236002909 Colicin V production protein; Region: Colicin_V; pfam02674 390236002910 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 390236002911 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 390236002912 homodimer interface [polypeptide binding]; other site 390236002913 active site 390236002914 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 390236002915 substrate binding site [chemical binding]; other site 390236002916 ATP binding site [chemical binding]; other site 390236002917 UGMP family protein; Validated; Region: PRK09604 390236002918 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 390236002919 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 390236002920 NodB motif; other site 390236002921 putative active site [active] 390236002922 putative catalytic site [active] 390236002923 Zn binding site [ion binding]; other site 390236002924 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 390236002925 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 390236002926 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 390236002927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 390236002928 DNA binding residues [nucleotide binding] 390236002929 Rod binding protein; Region: Rod-binding; cl01626 390236002930 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK12706 390236002931 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 390236002932 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 390236002933 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 390236002934 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 390236002935 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 390236002936 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 390236002937 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 390236002938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 390236002939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390236002940 active site 390236002941 ribosomal protein L21; Region: L21; TIGR00061 390236002942 hypothetical protein; Provisional; Region: PRK14553 390236002943 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 390236002944 GTPase CgtA; Reviewed; Region: obgE; PRK12299 390236002945 GTP1/OBG; Region: GTP1_OBG; pfam01018 390236002946 Obg GTPase; Region: Obg; cd01898 390236002947 G1 box; other site 390236002948 GTP/Mg2+ binding site [chemical binding]; other site 390236002949 Switch I region; other site 390236002950 G2 box; other site 390236002951 G3 box; other site 390236002952 Switch II region; other site 390236002953 G4 box; other site 390236002954 G5 box; other site 390236002955 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 390236002956 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 390236002957 active site 390236002958 (T/H)XGH motif; other site 390236002959 Transcriptional regulator [Transcription]; Region: LytR; COG1316 390236002960 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 390236002961 Oligomerisation domain; Region: Oligomerisation; cl00519 390236002962 SpoVG; Region: SpoVG; cl00915 390236002963 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 390236002964 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 390236002965 5S rRNA interface [nucleotide binding]; other site 390236002966 CTC domain interface [polypeptide binding]; other site 390236002967 L16 interface [polypeptide binding]; other site 390236002968 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 390236002969 putative active site [active] 390236002970 catalytic residue [active] 390236002971 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 390236002972 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 390236002973 Ligand Binding Site [chemical binding]; other site 390236002974 FtsH Extracellular; Region: FtsH_ext; pfam06480 390236002975 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 390236002976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236002977 Walker A motif; other site 390236002978 ATP binding site [chemical binding]; other site 390236002979 Walker B motif; other site 390236002980 arginine finger; other site 390236002981 Peptidase family M41; Region: Peptidase_M41; pfam01434 390236002982 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 390236002983 thymidylate kinase; Region: DTMP_kinase; TIGR00041 390236002984 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 390236002985 TMP-binding site; other site 390236002986 ATP-binding site [chemical binding]; other site 390236002987 Family of unknown function (DUF490); Region: DUF490; pfam04357 390236002988 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 390236002989 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 390236002990 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 390236002991 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 390236002992 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 390236002993 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 390236002994 Surface antigen; Region: Bac_surface_Ag; pfam01103 390236002995 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 390236002996 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 390236002997 MutS domain I; Region: MutS_I; pfam01624 390236002998 MutS domain II; Region: MutS_II; pfam05188 390236002999 MutS domain III; Region: MutS_III; pfam05192 390236003000 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 390236003001 Walker A/P-loop; other site 390236003002 ATP binding site [chemical binding]; other site 390236003003 Q-loop/lid; other site 390236003004 ABC transporter signature motif; other site 390236003005 Walker B; other site 390236003006 D-loop; other site 390236003007 H-loop/switch region; other site 390236003008 comF family protein; Region: comF; TIGR00201 390236003009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 390236003010 active site 390236003011 hypothetical protein; Provisional; Region: PRK14630 390236003012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 390236003013 heptamer interface [polypeptide binding]; other site 390236003014 Sm1 motif; other site 390236003015 hexamer interface [polypeptide binding]; other site 390236003016 RNA binding site [nucleotide binding]; other site 390236003017 Sm2 motif; other site 390236003018 transcription termination factor NusA; Region: NusA; TIGR01953 390236003019 NusA N-terminal domain; Region: NusA_N; pfam08529 390236003020 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 390236003021 RNA binding site [nucleotide binding]; other site 390236003022 homodimer interface [polypeptide binding]; other site 390236003023 NusA-like KH domain; Region: KH_5; pfam13184 390236003024 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 390236003025 G-X-X-G motif; other site 390236003026 translation initiation factor IF-2; Region: IF-2; TIGR00487 390236003027 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 390236003028 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 390236003029 G1 box; other site 390236003030 putative GEF interaction site [polypeptide binding]; other site 390236003031 GTP/Mg2+ binding site [chemical binding]; other site 390236003032 Switch I region; other site 390236003033 G2 box; other site 390236003034 G3 box; other site 390236003035 Switch II region; other site 390236003036 G4 box; other site 390236003037 G5 box; other site 390236003038 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 390236003039 Translation-initiation factor 2; Region: IF-2; pfam11987 390236003040 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 390236003041 ribosome-binding factor A; Region: rbfA; TIGR00082 390236003042 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 390236003043 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 390236003044 RNA binding site [nucleotide binding]; other site 390236003045 active site 390236003046 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 390236003047 16S/18S rRNA binding site [nucleotide binding]; other site 390236003048 S13e-L30e interaction site [polypeptide binding]; other site 390236003049 25S rRNA binding site [nucleotide binding]; other site 390236003050 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 390236003051 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 390236003052 RNase E interface [polypeptide binding]; other site 390236003053 trimer interface [polypeptide binding]; other site 390236003054 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 390236003055 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 390236003056 RNase E interface [polypeptide binding]; other site 390236003057 trimer interface [polypeptide binding]; other site 390236003058 active site 390236003059 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 390236003060 putative nucleic acid binding region [nucleotide binding]; other site 390236003061 G-X-X-G motif; other site 390236003062 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 390236003063 RNA binding site [nucleotide binding]; other site 390236003064 Predicted permeases [General function prediction only]; Region: COG0795 390236003065 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 390236003066 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 390236003067 Predicted permeases [General function prediction only]; Region: COG0795 390236003068 tRNA-guanine transglycosylase, queuosine-34-forming; Region: Q_tRNA_tgt; TIGR00430 390236003069 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 390236003070 integral membrane protein MviN; Region: mviN; TIGR01695 390236003071 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 390236003072 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 390236003073 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 390236003074 Flavoprotein; Region: Flavoprotein; pfam02441 390236003075 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 390236003076 sodium/panthothenate symporter; Provisional; Region: panF; PRK09442 390236003077 Na binding site [ion binding]; other site 390236003078 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 390236003079 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 390236003080 active site 390236003081 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 390236003082 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 390236003083 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 390236003084 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 390236003085 TIGR00255 family protein; Region: TIGR00255 390236003086 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 390236003087 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 390236003088 cytidylate kinase; Provisional; Region: PRK04182 390236003089 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 390236003090 CMP-binding site; other site 390236003091 The sites determining sugar specificity; other site 390236003092 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 390236003093 tRNA delta(2)-isopentenylpyrophosphate transferase; Provisional; Region: miaA; PRK14729 390236003094 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 390236003095 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 390236003096 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 390236003097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390236003098 ATP binding site [chemical binding]; other site 390236003099 putative Mg++ binding site [ion binding]; other site 390236003100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390236003101 nucleotide binding region [chemical binding]; other site 390236003102 ATP-binding site [chemical binding]; other site 390236003103 Helicase associated domain (HA2); Region: HA2; pfam04408 390236003104 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 390236003105 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 390236003106 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 390236003107 active site 390236003108 interdomain interaction site; other site 390236003109 putative metal-binding site [ion binding]; other site 390236003110 nucleotide binding site [chemical binding]; other site 390236003111 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 390236003112 domain I; other site 390236003113 phosphate binding site [ion binding]; other site 390236003114 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 390236003115 domain II; other site 390236003116 domain III; other site 390236003117 nucleotide binding site [chemical binding]; other site 390236003118 DNA binding groove [nucleotide binding] 390236003119 catalytic site [active] 390236003120 domain IV; other site 390236003121 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 390236003122 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 390236003123 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 390236003124 active site 390236003125 metal binding site [ion binding]; metal-binding site 390236003126 DNA binding site [nucleotide binding] 390236003127 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 390236003128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236003129 Walker A/P-loop; other site 390236003130 ATP binding site [chemical binding]; other site 390236003131 Q-loop/lid; other site 390236003132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 390236003133 ABC transporter signature motif; other site 390236003134 Walker B; other site 390236003135 D-loop; other site 390236003136 H-loop/switch region; other site 390236003137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 390236003138 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 390236003139 nucleotide binding site [chemical binding]; other site 390236003140 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 390236003141 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 390236003142 HIGH motif; other site 390236003143 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 390236003144 active site 390236003145 KMSKS motif; other site 390236003146 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 390236003147 tRNA binding surface [nucleotide binding]; other site 390236003148 anticodon binding site; other site 390236003149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236003150 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 390236003151 Walker A motif; other site 390236003152 ATP binding site [chemical binding]; other site 390236003153 Walker B motif; other site 390236003154 arginine finger; other site 390236003155 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 390236003156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 390236003157 Walker A motif; other site 390236003158 ATP binding site [chemical binding]; other site 390236003159 Walker B motif; other site 390236003160 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 390236003161 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 390236003162 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 390236003163 active site 390236003164 substrate binding site [chemical binding]; other site 390236003165 metal binding site [ion binding]; metal-binding site 390236003166 excinuclease ABC subunit B; Provisional; Region: PRK05298 390236003167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 390236003168 ATP binding site [chemical binding]; other site 390236003169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 390236003170 nucleotide binding region [chemical binding]; other site 390236003171 ATP-binding site [chemical binding]; other site 390236003172 Ultra-violet resistance protein B; Region: UvrB; pfam12344 390236003173 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 390236003174 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 390236003175 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 390236003176 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 390236003177 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 390236003178 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 390236003179 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 390236003180 RNA/DNA hybrid binding site [nucleotide binding]; other site 390236003181 active site 390236003182 arginine deiminase; Provisional; Region: PRK01388 390236003183 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 390236003184 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 390236003185 Exported protein precursor (EppA/BapA); Region: EppA_BapA; pfam07268 390236003186 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236003187 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003188 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236003189 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003190 P-loop; other site 390236003191 Magnesium ion binding site [ion binding]; other site 390236003192 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003193 Magnesium ion binding site [ion binding]; other site 390236003194 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236003195 potential frameshift: common BLAST hit: gi|343127227|ref|YP_004777230.1| methyl-accepting chemotaxis (MCP) signaling domain-containing 390236003196 potential frameshift: common BLAST hit: gi|343127227|ref|YP_004777230.1| methyl-accepting chemotaxis (MCP) signaling domain-containing 390236003197 potential frameshift: common BLAST hit: gi|343127227|ref|YP_004777230.1| methyl-accepting chemotaxis (MCP) signaling domain-containing 390236003198 potential frameshift: common BLAST hit: gi|343127227|ref|YP_004777230.1| methyl-accepting chemotaxis (MCP) signaling domain-containing 390236003199 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236003200 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236003201 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003202 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236003203 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 390236003204 Isochorismatase family; Region: Isochorismatase; pfam00857 390236003205 catalytic triad [active] 390236003206 metal binding site [ion binding]; metal-binding site 390236003207 conserved cis-peptide bond; other site 390236003208 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003209 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003210 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390236003211 Walker B motif; other site 390236003212 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390236003213 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390236003214 Walker B motif; other site 390236003215 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 390236003216 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236003217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003218 P-loop; other site 390236003219 Magnesium ion binding site [ion binding]; other site 390236003220 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236003221 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003222 Magnesium ion binding site [ion binding]; other site 390236003223 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236003224 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 390236003225 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 390236003226 Int/Topo IB signature motif; other site 390236003227 DNA binding site [nucleotide binding] 390236003228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 390236003229 Predicted helicase [General function prediction only]; Region: COG4889 390236003230 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236003231 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236003232 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236003233 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236003234 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236003235 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236003236 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236003237 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236003238 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003239 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236003240 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003241 P-loop; other site 390236003242 Magnesium ion binding site [ion binding]; other site 390236003243 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003244 Magnesium ion binding site [ion binding]; other site 390236003245 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236003246 potential frameshift: common BLAST hit: gi|219873198|ref|YP_002477285.1| putative lipoprotein 390236003247 potential frameshift: common BLAST hit: gi|224984523|ref|YP_002642011.1| putative lipoprotein 390236003248 Borrelia outer surface protein D (OspD); Region: OspD; pfam03207 390236003249 Borrelia outer surface protein D (OspD); Region: OspD; pfam03207 390236003250 potential frameshift: common BLAST hit: gi|219873277|ref|YP_002477364.1| immunogenic protein P37 390236003251 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003252 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003253 ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118 390236003254 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236003255 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 390236003256 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 390236003257 DUF276; Region: DUF276; pfam03434 390236003258 Protein of unknown function (DUF735); Region: DUF735; pfam05246 390236003259 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236003260 Protein of unknown function (DUF685); Region: DUF685; pfam05085 390236003261 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 390236003262 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 390236003263 Borrelia lipoprotein; Region: Lipoprotein_1; pfam00820 390236003264 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 390236003265 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 390236003266 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 390236003267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003268 P-loop; other site 390236003269 Magnesium ion binding site [ion binding]; other site 390236003270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 390236003271 Magnesium ion binding site [ion binding]; other site 390236003272 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 390236003273 Protein of unknown function, DUF261; Region: DUF261; pfam03196 390236003274 Decorin binding protein; Region: Decorin_bind; pfam02352 390236003275 Decorin binding protein; Region: Decorin_bind; pfam02352 390236003276 Protein of unknown function, DUF603; Region: DUF603; pfam04645 390236003277 Phage terminase large subunit; Region: Terminase_3; cl12054 390236003278 Terminase-like family; Region: Terminase_6; pfam03237 390236003279 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 390236003280 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 390236003281 peptide binding site [polypeptide binding]; other site 390236003282 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 390236003283 Protein of unknown function (DUF1357); Region: DUF1357; pfam07094 390236003284 Lyme disease proteins of unknown function; Region: DUF228; pfam02989 390236003285 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 390236003286 Protein of unknown function (DUF1506); Region: DUF1506; pfam07405 390236003287 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 390236003288 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 390236003289 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 390236003290 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 390236003291 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 390236003292 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 390236003293 Protein of unknown function (DUF693); Region: DUF693; pfam05113 390236003294 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 390236003295 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236003296 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236003297 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 390236003298 OMS28 porin; Region: OMS28_porin; pfam03532 390236003299 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847