-- dump date 20140619_003144 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1146883000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1146883000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883000004 Walker A motif; other site 1146883000005 ATP binding site [chemical binding]; other site 1146883000006 Walker B motif; other site 1146883000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1146883000008 arginine finger; other site 1146883000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1146883000010 DnaA box-binding interface [nucleotide binding]; other site 1146883000011 DNA polymerase III subunit beta; Validated; Region: PRK07761 1146883000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1146883000013 putative DNA binding surface [nucleotide binding]; other site 1146883000014 dimer interface [polypeptide binding]; other site 1146883000015 beta-clamp/clamp loader binding surface; other site 1146883000016 beta-clamp/translesion DNA polymerase binding surface; other site 1146883000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1146883000018 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1146883000019 recombination protein F; Reviewed; Region: recF; PRK00064 1146883000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883000021 Walker A/P-loop; other site 1146883000022 ATP binding site [chemical binding]; other site 1146883000023 Q-loop/lid; other site 1146883000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883000025 ABC transporter signature motif; other site 1146883000026 Walker B; other site 1146883000027 D-loop; other site 1146883000028 H-loop/switch region; other site 1146883000029 Protein of unknown function (DUF721); Region: DUF721; cl02324 1146883000030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1146883000031 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1146883000032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883000033 Walker A/P-loop; other site 1146883000034 ATP binding site [chemical binding]; other site 1146883000035 Q-loop/lid; other site 1146883000036 ABC transporter signature motif; other site 1146883000037 Walker B; other site 1146883000038 D-loop; other site 1146883000039 H-loop/switch region; other site 1146883000040 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1146883000041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1146883000042 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1146883000043 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1146883000044 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1146883000045 putative NAD(P) binding site [chemical binding]; other site 1146883000046 putative active site [active] 1146883000047 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1146883000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883000049 ATP binding site [chemical binding]; other site 1146883000050 Mg2+ binding site [ion binding]; other site 1146883000051 G-X-G motif; other site 1146883000052 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1146883000053 anchoring element; other site 1146883000054 dimer interface [polypeptide binding]; other site 1146883000055 ATP binding site [chemical binding]; other site 1146883000056 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1146883000057 active site 1146883000058 putative metal-binding site [ion binding]; other site 1146883000059 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1146883000060 DNA gyrase subunit A; Validated; Region: PRK05560 1146883000061 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1146883000062 CAP-like domain; other site 1146883000063 active site 1146883000064 primary dimer interface [polypeptide binding]; other site 1146883000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1146883000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1146883000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1146883000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1146883000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1146883000070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1146883000071 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1146883000072 integrase; Provisional; Region: int; PHA02601 1146883000073 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883000074 active site 1146883000075 Int/Topo IB signature motif; other site 1146883000076 catalytic residues [active] 1146883000077 DNA binding site [nucleotide binding] 1146883000078 Helix-turn-helix domain; Region: HTH_17; cl17695 1146883000079 TrwC relaxase; Region: TrwC; pfam08751 1146883000080 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883000081 AAA domain; Region: AAA_30; pfam13604 1146883000082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883000083 AAA domain; Region: AAA_21; pfam13304 1146883000084 Walker A/P-loop; other site 1146883000085 ATP binding site [chemical binding]; other site 1146883000086 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1146883000087 putative active site [active] 1146883000088 putative metal-binding site [ion binding]; other site 1146883000089 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1146883000090 Part of AAA domain; Region: AAA_19; pfam13245 1146883000091 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1146883000092 Family description; Region: UvrD_C_2; pfam13538 1146883000093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883000094 S-adenosylmethionine binding site [chemical binding]; other site 1146883000095 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1146883000096 active site 1146883000097 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1146883000098 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1146883000099 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 1146883000100 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883000101 dimer interface [polypeptide binding]; other site 1146883000102 active site 1146883000103 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1146883000104 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1146883000105 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1146883000106 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1146883000107 glutamine binding [chemical binding]; other site 1146883000108 catalytic triad [active] 1146883000109 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1146883000110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883000111 active site 1146883000112 ATP binding site [chemical binding]; other site 1146883000113 substrate binding site [chemical binding]; other site 1146883000114 activation loop (A-loop); other site 1146883000115 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883000116 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883000117 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883000118 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883000119 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1146883000120 active site 1146883000121 ATP binding site [chemical binding]; other site 1146883000122 substrate binding site [chemical binding]; other site 1146883000123 activation loop (A-loop); other site 1146883000124 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1146883000125 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1146883000126 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1146883000127 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1146883000128 Protein phosphatase 2C; Region: PP2C; pfam00481 1146883000129 active site 1146883000130 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1146883000131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1146883000132 phosphopeptide binding site; other site 1146883000133 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1146883000134 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1146883000135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1146883000136 phosphopeptide binding site; other site 1146883000137 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1146883000138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883000139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883000140 active site 1146883000141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883000142 Coenzyme A binding pocket [chemical binding]; other site 1146883000143 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1146883000144 catalytic site [active] 1146883000145 putative active site [active] 1146883000146 putative substrate binding site [chemical binding]; other site 1146883000147 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1146883000148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883000149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883000150 DNA binding residues [nucleotide binding] 1146883000151 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1146883000152 active site 1146883000153 catalytic residues [active] 1146883000154 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1146883000155 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1146883000156 MOSC domain; Region: MOSC; pfam03473 1146883000157 S4 domain; Region: S4_2; pfam13275 1146883000158 aminotransferase; Validated; Region: PRK07777 1146883000159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883000160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883000161 homodimer interface [polypeptide binding]; other site 1146883000162 catalytic residue [active] 1146883000163 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1146883000164 active site 1146883000165 catalytic triad [active] 1146883000166 dimer interface [polypeptide binding]; other site 1146883000167 PRC-barrel domain; Region: PRC; pfam05239 1146883000168 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1146883000169 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883000170 putative catalytic site [active] 1146883000171 putative phosphate binding site [ion binding]; other site 1146883000172 putative metal binding site [ion binding]; other site 1146883000173 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1146883000174 putative active site; other site 1146883000175 putative metal binding residues [ion binding]; other site 1146883000176 signature motif; other site 1146883000177 putative triphosphate binding site [ion binding]; other site 1146883000178 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1146883000179 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883000180 putative active site [active] 1146883000181 putative metal binding site [ion binding]; other site 1146883000182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1146883000183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883000184 DNA-binding site [nucleotide binding]; DNA binding site 1146883000185 UTRA domain; Region: UTRA; pfam07702 1146883000186 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1146883000187 hydrophobic ligand binding site; other site 1146883000188 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1146883000189 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1146883000190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883000191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883000192 DNA binding residues [nucleotide binding] 1146883000193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1146883000194 nucleotide binding site [chemical binding]; other site 1146883000195 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1146883000196 G3 box; other site 1146883000197 Switch II region; other site 1146883000198 GTP/Mg2+ binding site [chemical binding]; other site 1146883000199 G4 box; other site 1146883000200 G5 box; other site 1146883000201 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1146883000202 G1 box; other site 1146883000203 GTP/Mg2+ binding site [chemical binding]; other site 1146883000204 G2 box; other site 1146883000205 Switch I region; other site 1146883000206 G3 box; other site 1146883000207 Switch II region; other site 1146883000208 G4 box; other site 1146883000209 enoyl-CoA hydratase; Provisional; Region: PRK08140 1146883000210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883000211 substrate binding site [chemical binding]; other site 1146883000212 oxyanion hole (OAH) forming residues; other site 1146883000213 trimer interface [polypeptide binding]; other site 1146883000214 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883000215 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1146883000216 active site 1146883000217 ATP binding site [chemical binding]; other site 1146883000218 substrate binding site [chemical binding]; other site 1146883000219 activation loop (A-loop); other site 1146883000220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883000221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1146883000222 active site 1146883000223 ATP binding site [chemical binding]; other site 1146883000224 substrate binding site [chemical binding]; other site 1146883000225 activation loop (A-loop); other site 1146883000226 competence damage-inducible protein A; Provisional; Region: PRK00549 1146883000227 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1146883000228 MPT binding site; other site 1146883000229 Competence-damaged protein; Region: CinA; pfam02464 1146883000230 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1146883000231 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883000232 active site 1146883000233 PAS fold; Region: PAS_4; pfam08448 1146883000234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000235 putative active site [active] 1146883000236 heme pocket [chemical binding]; other site 1146883000237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000239 metal binding site [ion binding]; metal-binding site 1146883000240 active site 1146883000241 I-site; other site 1146883000242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883000243 LabA_like proteins; Region: LabA_like; cd06167 1146883000244 putative metal binding site [ion binding]; other site 1146883000245 PilZ domain; Region: PilZ; pfam07238 1146883000246 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1146883000247 G1 box; other site 1146883000248 GTP/Mg2+ binding site [chemical binding]; other site 1146883000249 G2 box; other site 1146883000250 Switch I region; other site 1146883000251 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1146883000252 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1146883000253 G1 box; other site 1146883000254 G1 box; other site 1146883000255 GTP/Mg2+ binding site [chemical binding]; other site 1146883000256 GTP/Mg2+ binding site [chemical binding]; other site 1146883000257 G2 box; other site 1146883000258 Switch I region; other site 1146883000259 G3 box; other site 1146883000260 Switch II region; other site 1146883000261 G4 box; other site 1146883000262 G5 box; other site 1146883000263 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883000264 GAF domain; Region: GAF; cl17456 1146883000265 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1146883000266 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1146883000267 active site 1146883000268 GAF domain; Region: GAF_2; pfam13185 1146883000269 GAF domain; Region: GAF; pfam01590 1146883000270 PAS fold; Region: PAS_3; pfam08447 1146883000271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000272 putative active site [active] 1146883000273 heme pocket [chemical binding]; other site 1146883000274 PAS fold; Region: PAS_4; pfam08448 1146883000275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000276 putative active site [active] 1146883000277 heme pocket [chemical binding]; other site 1146883000278 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1146883000279 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883000280 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883000281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883000282 ATP binding site [chemical binding]; other site 1146883000283 Mg2+ binding site [ion binding]; other site 1146883000284 G-X-G motif; other site 1146883000285 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1146883000286 thiamine phosphate binding site [chemical binding]; other site 1146883000287 active site 1146883000288 pyrophosphate binding site [ion binding]; other site 1146883000289 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1146883000290 ThiS interaction site; other site 1146883000291 putative active site [active] 1146883000292 tetramer interface [polypeptide binding]; other site 1146883000293 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1146883000294 thiS-thiF/thiG interaction site; other site 1146883000295 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1146883000296 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1146883000297 active site 1146883000298 pyrophosphate binding site [ion binding]; other site 1146883000299 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1146883000300 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1146883000301 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1146883000302 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1146883000303 dimer interface [polypeptide binding]; other site 1146883000304 substrate binding site [chemical binding]; other site 1146883000305 ATP binding site [chemical binding]; other site 1146883000306 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1146883000307 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1146883000308 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1146883000309 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1146883000310 Protein of unknown function DUF82; Region: DUF82; pfam01927 1146883000311 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1146883000312 classical (c) SDRs; Region: SDR_c; cd05233 1146883000313 NAD(P) binding site [chemical binding]; other site 1146883000314 active site 1146883000315 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1146883000316 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1146883000317 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1146883000318 NAD(P) binding site [chemical binding]; other site 1146883000319 substrate binding site [chemical binding]; other site 1146883000320 dimer interface [polypeptide binding]; other site 1146883000321 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1146883000322 haloalkane dehalogenase; Provisional; Region: PRK00870 1146883000323 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1146883000324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883000325 S-adenosylmethionine binding site [chemical binding]; other site 1146883000326 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883000328 G-X-G motif; other site 1146883000329 MarR family; Region: MarR_2; cl17246 1146883000330 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883000331 PAS domain; Region: PAS_9; pfam13426 1146883000332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000333 putative active site [active] 1146883000334 heme pocket [chemical binding]; other site 1146883000335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000337 metal binding site [ion binding]; metal-binding site 1146883000338 active site 1146883000339 I-site; other site 1146883000340 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1146883000341 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1146883000342 active site 1146883000343 DNA binding site [nucleotide binding] 1146883000344 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1146883000345 DNA binding site [nucleotide binding] 1146883000346 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1146883000347 dimer interface [polypeptide binding]; other site 1146883000348 ADP-ribose binding site [chemical binding]; other site 1146883000349 active site 1146883000350 nudix motif; other site 1146883000351 metal binding site [ion binding]; metal-binding site 1146883000352 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1146883000353 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1146883000354 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1146883000355 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1146883000356 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1146883000357 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1146883000358 Predicted membrane protein [Function unknown]; Region: COG2323 1146883000359 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1146883000360 MarR family; Region: MarR; pfam01047 1146883000361 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1146883000362 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1146883000363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883000364 Walker A/P-loop; other site 1146883000365 ATP binding site [chemical binding]; other site 1146883000366 Q-loop/lid; other site 1146883000367 ABC transporter signature motif; other site 1146883000368 Walker B; other site 1146883000369 D-loop; other site 1146883000370 H-loop/switch region; other site 1146883000371 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1146883000372 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1146883000373 FMN binding site [chemical binding]; other site 1146883000374 active site 1146883000375 substrate binding site [chemical binding]; other site 1146883000376 catalytic residue [active] 1146883000377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000378 PAS domain; Region: PAS_9; pfam13426 1146883000379 putative active site [active] 1146883000380 heme pocket [chemical binding]; other site 1146883000381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000383 metal binding site [ion binding]; metal-binding site 1146883000384 active site 1146883000385 I-site; other site 1146883000386 GAF domain; Region: GAF; cl17456 1146883000387 GAF domain; Region: GAF_2; pfam13185 1146883000388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883000389 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1146883000390 Beta-lactamase; Region: Beta-lactamase; pfam00144 1146883000391 short chain dehydrogenase; Provisional; Region: PRK06197 1146883000392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000393 NAD(P) binding site [chemical binding]; other site 1146883000394 active site 1146883000395 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883000396 MarR family; Region: MarR; pfam01047 1146883000397 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883000398 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1146883000399 putative active site [active] 1146883000400 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1146883000401 putative hydrophobic ligand binding site [chemical binding]; other site 1146883000402 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1146883000403 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1146883000404 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1146883000405 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1146883000406 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883000407 catalytic loop [active] 1146883000408 iron binding site [ion binding]; other site 1146883000409 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1146883000410 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1146883000411 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1146883000412 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1146883000413 membrane protein FdrA; Validated; Region: PRK06091 1146883000414 CoA-ligase; Region: Ligase_CoA; pfam00549 1146883000415 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1146883000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1146883000417 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883000418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1146883000419 dimer interface [polypeptide binding]; other site 1146883000420 putative CheW interface [polypeptide binding]; other site 1146883000421 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 1146883000422 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1146883000423 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1146883000424 putative substrate binding site [chemical binding]; other site 1146883000425 nucleotide binding site [chemical binding]; other site 1146883000426 nucleotide binding site [chemical binding]; other site 1146883000427 homodimer interface [polypeptide binding]; other site 1146883000428 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1146883000429 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1146883000430 active site 1146883000431 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1146883000432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883000433 ATP binding site [chemical binding]; other site 1146883000434 putative Mg++ binding site [ion binding]; other site 1146883000435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883000436 nucleotide binding region [chemical binding]; other site 1146883000437 ATP-binding site [chemical binding]; other site 1146883000438 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1146883000439 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883000440 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883000441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883000442 catalytic residue [active] 1146883000443 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1146883000444 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1146883000445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883000446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883000447 DNA binding residues [nucleotide binding] 1146883000448 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1146883000449 active site 1146883000450 putative catalytic site [active] 1146883000451 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1146883000452 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1146883000453 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1146883000454 potential frameshift: common BLAST hit: gi|284989430|ref|YP_003407984.1| Deoxyribodipyrimidine photo-lyase 1146883000455 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1146883000456 DNA photolyase; Region: DNA_photolyase; pfam00875 1146883000457 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883000458 anti sigma factor interaction site; other site 1146883000459 regulatory phosphorylation site [posttranslational modification]; other site 1146883000460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883000461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883000462 active site 1146883000463 phosphorylation site [posttranslational modification] 1146883000464 intermolecular recognition site; other site 1146883000465 dimerization interface [polypeptide binding]; other site 1146883000466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883000467 DNA binding site [nucleotide binding] 1146883000468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883000469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883000470 dimerization interface [polypeptide binding]; other site 1146883000471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883000472 dimer interface [polypeptide binding]; other site 1146883000473 phosphorylation site [posttranslational modification] 1146883000474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883000475 ATP binding site [chemical binding]; other site 1146883000476 Mg2+ binding site [ion binding]; other site 1146883000477 G-X-G motif; other site 1146883000478 Sporulation and spore germination; Region: Germane; pfam10646 1146883000479 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1146883000480 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1146883000481 putative DNA binding site [nucleotide binding]; other site 1146883000482 catalytic residue [active] 1146883000483 putative H2TH interface [polypeptide binding]; other site 1146883000484 putative catalytic residues [active] 1146883000485 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1146883000486 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1146883000487 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1146883000488 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1146883000489 Protein of unknown function (DUF461); Region: DUF461; cl01071 1146883000490 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1146883000491 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1146883000492 Na binding site [ion binding]; other site 1146883000493 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1146883000494 dimanganese center [ion binding]; other site 1146883000495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883000496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883000497 ATP binding site [chemical binding]; other site 1146883000498 Mg2+ binding site [ion binding]; other site 1146883000499 G-X-G motif; other site 1146883000500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883000501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1146883000502 active site 1146883000503 phosphorylation site [posttranslational modification] 1146883000504 intermolecular recognition site; other site 1146883000505 dimerization interface [polypeptide binding]; other site 1146883000506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883000507 DNA binding residues [nucleotide binding] 1146883000508 dimerization interface [polypeptide binding]; other site 1146883000509 Predicted membrane protein [Function unknown]; Region: COG3428 1146883000510 Bacterial PH domain; Region: DUF304; pfam03703 1146883000511 Bacterial PH domain; Region: DUF304; cl01348 1146883000512 Bacterial PH domain; Region: DUF304; pfam03703 1146883000513 Bacterial PH domain; Region: DUF304; cl01348 1146883000514 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1146883000515 active site residue [active] 1146883000516 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1146883000517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883000518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883000519 DNA binding residues [nucleotide binding] 1146883000520 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1146883000521 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1146883000522 dimer interface [polypeptide binding]; other site 1146883000523 acyl-activating enzyme (AAE) consensus motif; other site 1146883000524 putative active site [active] 1146883000525 AMP binding site [chemical binding]; other site 1146883000526 putative CoA binding site [chemical binding]; other site 1146883000527 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883000528 Cytochrome P450; Region: p450; cl12078 1146883000529 SEC-C motif; Region: SEC-C; pfam02810 1146883000530 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1146883000531 NAD(P) binding site [chemical binding]; other site 1146883000532 catalytic residues [active] 1146883000533 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1146883000534 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1146883000535 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1146883000536 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1146883000537 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1146883000538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883000539 FeS/SAM binding site; other site 1146883000540 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1146883000541 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1146883000542 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1146883000543 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1146883000544 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1146883000545 substrate binding pocket [chemical binding]; other site 1146883000546 chain length determination region; other site 1146883000547 substrate-Mg2+ binding site; other site 1146883000548 catalytic residues [active] 1146883000549 aspartate-rich region 1; other site 1146883000550 active site lid residues [active] 1146883000551 aspartate-rich region 2; other site 1146883000552 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1146883000553 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1146883000554 active site lid residues [active] 1146883000555 substrate binding pocket [chemical binding]; other site 1146883000556 catalytic residues [active] 1146883000557 substrate-Mg2+ binding site; other site 1146883000558 aspartate-rich region 1; other site 1146883000559 aspartate-rich region 2; other site 1146883000560 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1146883000561 active site lid residues [active] 1146883000562 substrate binding pocket [chemical binding]; other site 1146883000563 catalytic residues [active] 1146883000564 substrate-Mg2+ binding site; other site 1146883000565 aspartate-rich region 1; other site 1146883000566 aspartate-rich region 2; other site 1146883000567 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1146883000568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000569 active site 1146883000570 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1146883000571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883000572 S-adenosylmethionine binding site [chemical binding]; other site 1146883000573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1146883000574 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1146883000575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883000576 AMP binding site [chemical binding]; other site 1146883000577 active site 1146883000578 CoA binding site [chemical binding]; other site 1146883000579 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883000580 CoenzymeA binding site [chemical binding]; other site 1146883000581 subunit interaction site [polypeptide binding]; other site 1146883000582 PHB binding site; other site 1146883000583 peptide synthase; Provisional; Region: PRK12467 1146883000584 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883000585 Cytochrome P450; Region: p450; cl12078 1146883000586 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1146883000587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883000588 acyl-activating enzyme (AAE) consensus motif; other site 1146883000589 AMP binding site [chemical binding]; other site 1146883000590 active site 1146883000591 CoA binding site [chemical binding]; other site 1146883000592 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1146883000593 hypothetical protein; Provisional; Region: PRK08262 1146883000594 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1146883000595 metal binding site [ion binding]; metal-binding site 1146883000596 arginine deiminase; Provisional; Region: PRK01388 1146883000597 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1146883000598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000599 NAD(P) binding site [chemical binding]; other site 1146883000600 active site 1146883000601 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883000602 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883000603 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1146883000604 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1146883000605 Predicted membrane protein [Function unknown]; Region: COG4129 1146883000606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883000607 dimer interface [polypeptide binding]; other site 1146883000608 conserved gate region; other site 1146883000609 putative PBP binding loops; other site 1146883000610 ABC-ATPase subunit interface; other site 1146883000611 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1146883000612 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1146883000613 Walker A/P-loop; other site 1146883000614 ATP binding site [chemical binding]; other site 1146883000615 Q-loop/lid; other site 1146883000616 ABC transporter signature motif; other site 1146883000617 Walker B; other site 1146883000618 D-loop; other site 1146883000619 H-loop/switch region; other site 1146883000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1146883000621 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1146883000622 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1146883000623 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1146883000624 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883000625 DNA binding residues [nucleotide binding] 1146883000626 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1146883000627 haloalkane dehalogenase; Provisional; Region: PRK03592 1146883000628 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1146883000629 Predicted membrane protein [Function unknown]; Region: COG2119 1146883000630 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1146883000631 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1146883000632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883000633 GAF domain; Region: GAF; pfam01590 1146883000634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000635 PAS domain; Region: PAS_9; pfam13426 1146883000636 putative active site [active] 1146883000637 heme pocket [chemical binding]; other site 1146883000638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000640 metal binding site [ion binding]; metal-binding site 1146883000641 active site 1146883000642 I-site; other site 1146883000643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883000644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883000645 hypothetical protein; Provisional; Region: PRK04194 1146883000646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000648 metal binding site [ion binding]; metal-binding site 1146883000649 active site 1146883000650 I-site; other site 1146883000651 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1146883000652 AIR carboxylase; Region: AIRC; smart01001 1146883000653 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000655 metal binding site [ion binding]; metal-binding site 1146883000656 active site 1146883000657 I-site; other site 1146883000658 prephenate dehydratase; Provisional; Region: PRK11898 1146883000659 Prephenate dehydratase; Region: PDT; pfam00800 1146883000660 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1146883000661 putative L-Phe binding site [chemical binding]; other site 1146883000662 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1146883000663 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1146883000664 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1146883000665 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883000666 PIN domain; Region: PIN_3; pfam13470 1146883000667 MMPL family; Region: MMPL; pfam03176 1146883000668 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883000669 MarR family; Region: MarR_2; cl17246 1146883000670 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1146883000671 oligomerisation interface [polypeptide binding]; other site 1146883000672 mobile loop; other site 1146883000673 roof hairpin; other site 1146883000674 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1146883000675 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1146883000676 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883000677 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1146883000678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883000679 phosphate binding site [ion binding]; other site 1146883000680 seryl-tRNA synthetase; Provisional; Region: PRK05431 1146883000681 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1146883000682 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1146883000683 dimer interface [polypeptide binding]; other site 1146883000684 active site 1146883000685 motif 1; other site 1146883000686 motif 2; other site 1146883000687 motif 3; other site 1146883000688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883000689 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1146883000690 active site 1146883000691 motif I; other site 1146883000692 motif II; other site 1146883000693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1146883000694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883000695 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1146883000696 active site 1146883000697 motif I; other site 1146883000698 motif II; other site 1146883000699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1146883000700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1146883000701 dimer interface [polypeptide binding]; other site 1146883000702 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1146883000703 putative CheW interface [polypeptide binding]; other site 1146883000704 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1146883000705 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1146883000706 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1146883000707 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1146883000708 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883000709 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883000710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883000711 catalytic residue [active] 1146883000712 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1146883000713 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1146883000714 NAD(P) binding site [chemical binding]; other site 1146883000715 4-coumarate--CoA ligase; Region: PLN02246 1146883000716 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1146883000717 acyl-activating enzyme (AAE) consensus motif; other site 1146883000718 active site 1146883000719 putative CoA binding site [chemical binding]; other site 1146883000720 AMP binding site [chemical binding]; other site 1146883000721 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883000722 CoenzymeA binding site [chemical binding]; other site 1146883000723 subunit interaction site [polypeptide binding]; other site 1146883000724 PHB binding site; other site 1146883000725 dihydropteroate synthase; Region: DHPS; TIGR01496 1146883000726 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1146883000727 substrate binding pocket [chemical binding]; other site 1146883000728 dimer interface [polypeptide binding]; other site 1146883000729 inhibitor binding site; inhibition site 1146883000730 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1146883000731 putative active site [active] 1146883000732 putative catalytic site [active] 1146883000733 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1146883000734 Beta-lactamase; Region: Beta-lactamase; pfam00144 1146883000735 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1146883000736 IHF dimer interface [polypeptide binding]; other site 1146883000737 IHF - DNA interface [nucleotide binding]; other site 1146883000738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883000739 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883000740 active site 1146883000741 catalytic tetrad [active] 1146883000742 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883000743 GAF domain; Region: GAF; pfam01590 1146883000744 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883000745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883000746 PAS fold; Region: PAS_3; pfam08447 1146883000747 putative active site [active] 1146883000748 heme pocket [chemical binding]; other site 1146883000749 GAF domain; Region: GAF; pfam01590 1146883000750 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883000751 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883000752 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1146883000753 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1146883000754 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883000755 acyl-coenzyme A oxidase; Region: PLN02636 1146883000756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883000757 active site 1146883000758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883000759 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1146883000760 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883000761 dimer interface [polypeptide binding]; other site 1146883000762 active site 1146883000763 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1146883000764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000765 NAD(P) binding site [chemical binding]; other site 1146883000766 active site 1146883000767 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1146883000768 active site 2 [active] 1146883000769 active site 1 [active] 1146883000770 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1146883000771 Interdomain contacts; other site 1146883000772 Cytokine receptor motif; other site 1146883000773 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1146883000774 active site 1146883000775 catalytic site [active] 1146883000776 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1146883000777 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1146883000778 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1146883000779 active site 1146883000780 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 1146883000781 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 1146883000782 tetramerization interface [polypeptide binding]; other site 1146883000783 substrate binding pocket [chemical binding]; other site 1146883000784 catalytic residues [active] 1146883000785 inhibitor binding sites; inhibition site 1146883000786 NADP(H) binding site [chemical binding]; other site 1146883000787 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1146883000788 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1146883000789 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1146883000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883000791 dimer interface [polypeptide binding]; other site 1146883000792 conserved gate region; other site 1146883000793 putative PBP binding loops; other site 1146883000794 ABC-ATPase subunit interface; other site 1146883000795 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1146883000796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883000797 dimer interface [polypeptide binding]; other site 1146883000798 conserved gate region; other site 1146883000799 putative PBP binding loops; other site 1146883000800 ABC-ATPase subunit interface; other site 1146883000801 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1146883000802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883000803 Walker A/P-loop; other site 1146883000804 ATP binding site [chemical binding]; other site 1146883000805 Q-loop/lid; other site 1146883000806 ABC transporter signature motif; other site 1146883000807 Walker B; other site 1146883000808 D-loop; other site 1146883000809 H-loop/switch region; other site 1146883000810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1146883000811 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1146883000812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883000813 Walker A/P-loop; other site 1146883000814 ATP binding site [chemical binding]; other site 1146883000815 Q-loop/lid; other site 1146883000816 ABC transporter signature motif; other site 1146883000817 Walker B; other site 1146883000818 D-loop; other site 1146883000819 H-loop/switch region; other site 1146883000820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1146883000821 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1146883000822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883000823 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1146883000824 TAP-like protein; Region: Abhydrolase_4; pfam08386 1146883000825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883000826 DNA binding residues [nucleotide binding] 1146883000827 dimerization interface [polypeptide binding]; other site 1146883000828 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883000829 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883000830 Berberine and berberine like; Region: BBE; pfam08031 1146883000831 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1146883000832 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1146883000833 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1146883000834 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1146883000835 putative active site [active] 1146883000836 putative catalytic site [active] 1146883000837 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1146883000838 nudix motif; other site 1146883000839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883000840 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1146883000841 substrate binding site [chemical binding]; other site 1146883000842 oxyanion hole (OAH) forming residues; other site 1146883000843 trimer interface [polypeptide binding]; other site 1146883000844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883000845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883000846 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1146883000847 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1146883000848 NAD binding site [chemical binding]; other site 1146883000849 catalytic Zn binding site [ion binding]; other site 1146883000850 substrate binding site [chemical binding]; other site 1146883000851 structural Zn binding site [ion binding]; other site 1146883000852 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1146883000853 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1146883000854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883000855 motif II; other site 1146883000856 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1146883000857 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1146883000858 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 1146883000859 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1146883000860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883000861 putative ADP-binding pocket [chemical binding]; other site 1146883000862 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1146883000863 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1146883000864 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1146883000865 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1146883000866 active site 1146883000867 catalytic site [active] 1146883000868 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1146883000869 PemK-like protein; Region: PemK; pfam02452 1146883000870 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883000871 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883000872 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883000873 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883000874 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1146883000875 molybdopterin cofactor binding site; other site 1146883000876 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1146883000877 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1146883000878 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1146883000879 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1146883000880 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1146883000881 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1146883000882 putative active site [active] 1146883000883 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1146883000884 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1146883000885 putative active site [active] 1146883000886 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1146883000887 putative active site [active] 1146883000888 Autoinducer synthetase; Region: Autoind_synth; cl17404 1146883000889 The Eukaryotic (Putative) Sterol Transporter (EST) Family; Region: 2A060602; TIGR00918 1146883000890 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883000891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883000892 metal binding site [ion binding]; metal-binding site 1146883000893 active site 1146883000894 I-site; other site 1146883000895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883000896 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1146883000897 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1146883000898 inhibitor-cofactor binding pocket; inhibition site 1146883000899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883000900 catalytic residue [active] 1146883000901 Chain length determinant protein; Region: Wzz; cl15801 1146883000902 Chain length determinant protein; Region: Wzz; cl15801 1146883000903 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1146883000904 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1146883000905 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1146883000906 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1146883000907 active site 1146883000908 dimer interface [polypeptide binding]; other site 1146883000909 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1146883000910 Ligand Binding Site [chemical binding]; other site 1146883000911 Molecular Tunnel; other site 1146883000912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883000913 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883000914 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1146883000915 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1146883000916 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1146883000917 CoA-binding domain; Region: CoA_binding_3; pfam13727 1146883000918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000919 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1146883000920 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1146883000921 NAD(P) binding site [chemical binding]; other site 1146883000922 homodimer interface [polypeptide binding]; other site 1146883000923 substrate binding site [chemical binding]; other site 1146883000924 active site 1146883000925 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1146883000926 putative active site [active] 1146883000927 putative metal binding site [ion binding]; other site 1146883000928 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1146883000929 putative ADP-binding pocket [chemical binding]; other site 1146883000930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883000931 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1146883000932 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1146883000933 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1146883000934 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1146883000935 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1146883000936 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1146883000937 putative active site [active] 1146883000938 putative metal binding site [ion binding]; other site 1146883000939 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1146883000940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1146883000941 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883000942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883000943 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883000944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883000945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883000946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883000947 DNA binding residues [nucleotide binding] 1146883000948 dimerization interface [polypeptide binding]; other site 1146883000949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883000950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883000951 DNA binding residues [nucleotide binding] 1146883000952 dimerization interface [polypeptide binding]; other site 1146883000953 HTH-like domain; Region: HTH_21; pfam13276 1146883000954 Integrase core domain; Region: rve; pfam00665 1146883000955 Integrase core domain; Region: rve_3; pfam13683 1146883000956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1146883000957 Transposase; Region: HTH_Tnp_1; cl17663 1146883000958 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1146883000959 Ligand Binding Site [chemical binding]; other site 1146883000960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883000961 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1146883000962 Walker A/P-loop; other site 1146883000963 ATP binding site [chemical binding]; other site 1146883000964 Q-loop/lid; other site 1146883000965 ABC transporter signature motif; other site 1146883000966 Walker B; other site 1146883000967 D-loop; other site 1146883000968 H-loop/switch region; other site 1146883000969 Evidence 7 : Gene remnant 1146883000970 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1146883000971 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1146883000972 putative trimer interface [polypeptide binding]; other site 1146883000973 putative CoA binding site [chemical binding]; other site 1146883000974 O-Antigen ligase; Region: Wzy_C; pfam04932 1146883000975 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1146883000976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000977 NAD(P) binding site [chemical binding]; other site 1146883000978 active site 1146883000979 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1146883000980 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1146883000981 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1146883000982 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1146883000983 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1146883000984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883000985 NAD(P) binding site [chemical binding]; other site 1146883000986 active site 1146883000987 Right handed beta helix region; Region: Beta_helix; pfam13229 1146883000988 Right handed beta helix region; Region: Beta_helix; pfam13229 1146883000989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883000990 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883000991 active site 1146883000992 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1146883000993 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1146883000994 LDH/MDH dimer interface [polypeptide binding]; other site 1146883000995 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1146883000996 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1146883000997 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1146883000998 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1146883000999 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1146883001000 active site 1146883001001 substrate binding site [chemical binding]; other site 1146883001002 FMN binding site [chemical binding]; other site 1146883001003 putative catalytic residues [active] 1146883001004 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1146883001005 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1146883001006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883001007 active site 1146883001008 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883001009 extended (e) SDRs; Region: SDR_e; cd08946 1146883001010 NAD(P) binding site [chemical binding]; other site 1146883001011 active site 1146883001012 substrate binding site [chemical binding]; other site 1146883001013 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1146883001014 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1146883001015 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1146883001016 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1146883001017 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1146883001018 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1146883001019 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1146883001020 substrate binding site; other site 1146883001021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883001022 active site 1146883001023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883001024 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1146883001025 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1146883001026 Chain length determinant protein; Region: Wzz; cl15801 1146883001027 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1146883001028 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1146883001029 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1146883001030 trimer interface [polypeptide binding]; other site 1146883001031 active site 1146883001032 substrate binding site [chemical binding]; other site 1146883001033 CoA binding site [chemical binding]; other site 1146883001034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883001035 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1146883001036 NAD(P) binding site [chemical binding]; other site 1146883001037 active site 1146883001038 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1146883001039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883001040 AMP binding site [chemical binding]; other site 1146883001041 active site 1146883001042 acyl-activating enzyme (AAE) consensus motif; other site 1146883001043 CoA binding site [chemical binding]; other site 1146883001044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1146883001045 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1146883001046 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1146883001047 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1146883001048 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1146883001049 LDH/MDH dimer interface [polypeptide binding]; other site 1146883001050 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1146883001051 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1146883001052 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 1146883001053 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1146883001054 active site 1146883001055 Predicted membrane protein [Function unknown]; Region: COG2259 1146883001056 CGNR zinc finger; Region: zf-CGNR; pfam11706 1146883001057 Transglycosylase; Region: Transgly; pfam00912 1146883001058 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1146883001059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1146883001060 Integrase core domain; Region: rve; pfam00665 1146883001061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883001062 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1146883001063 phosphate binding site [ion binding]; other site 1146883001064 MarR family; Region: MarR_2; pfam12802 1146883001065 hypothetical protein; Validated; Region: PRK07586 1146883001066 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1146883001067 PYR/PP interface [polypeptide binding]; other site 1146883001068 dimer interface [polypeptide binding]; other site 1146883001069 TPP binding site [chemical binding]; other site 1146883001070 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1146883001071 TPP-binding site [chemical binding]; other site 1146883001072 dimer interface [polypeptide binding]; other site 1146883001073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1146883001074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1146883001075 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1146883001076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1146883001077 Coenzyme A transferase; Region: CoA_trans; cl17247 1146883001078 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1146883001079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883001080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883001081 active site 1146883001082 motif I; other site 1146883001083 motif II; other site 1146883001084 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1146883001085 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1146883001086 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1146883001087 putative active site [active] 1146883001088 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883001089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883001090 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1146883001091 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1146883001092 putative ADP-binding pocket [chemical binding]; other site 1146883001093 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1146883001094 dimer interface [polypeptide binding]; other site 1146883001095 active site 1146883001096 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1146883001097 substrate binding site [chemical binding]; other site 1146883001098 ATP binding site [chemical binding]; other site 1146883001099 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1146883001100 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1146883001101 active site 1146883001102 nucleotide binding site [chemical binding]; other site 1146883001103 HIGH motif; other site 1146883001104 KMSKS motif; other site 1146883001105 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1146883001106 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1146883001107 putative active site [active] 1146883001108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1146883001109 metal ion-dependent adhesion site (MIDAS); other site 1146883001110 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1146883001111 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883001112 NAD binding site [chemical binding]; other site 1146883001113 putative substrate binding site 2 [chemical binding]; other site 1146883001114 putative substrate binding site 1 [chemical binding]; other site 1146883001115 active site 1146883001116 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883001117 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1146883001118 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1146883001119 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883001120 TM-ABC transporter signature motif; other site 1146883001121 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883001122 TM-ABC transporter signature motif; other site 1146883001123 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883001124 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883001125 Walker A/P-loop; other site 1146883001126 ATP binding site [chemical binding]; other site 1146883001127 Q-loop/lid; other site 1146883001128 ABC transporter signature motif; other site 1146883001129 Walker B; other site 1146883001130 D-loop; other site 1146883001131 H-loop/switch region; other site 1146883001132 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883001133 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883001134 Walker A/P-loop; other site 1146883001135 ATP binding site [chemical binding]; other site 1146883001136 Q-loop/lid; other site 1146883001137 ABC transporter signature motif; other site 1146883001138 Walker B; other site 1146883001139 D-loop; other site 1146883001140 H-loop/switch region; other site 1146883001141 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883001142 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1146883001143 prephenate dehydrogenase; Validated; Region: PRK08507 1146883001144 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1146883001145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883001146 S-adenosylmethionine binding site [chemical binding]; other site 1146883001147 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1146883001148 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 1146883001149 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1146883001150 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1146883001151 nucleoside/Zn binding site; other site 1146883001152 dimer interface [polypeptide binding]; other site 1146883001153 catalytic motif [active] 1146883001154 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1146883001155 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1146883001156 substrate binding site [chemical binding]; other site 1146883001157 activation loop (A-loop); other site 1146883001158 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1146883001159 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1146883001160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883001161 Walker A motif; other site 1146883001162 ATP binding site [chemical binding]; other site 1146883001163 Walker B motif; other site 1146883001164 arginine finger; other site 1146883001165 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1146883001166 hypothetical protein; Validated; Region: PRK00153 1146883001167 recombination protein RecR; Reviewed; Region: recR; PRK00076 1146883001168 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1146883001169 RecR protein; Region: RecR; pfam02132 1146883001170 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1146883001171 putative active site [active] 1146883001172 putative metal-binding site [ion binding]; other site 1146883001173 tetramer interface [polypeptide binding]; other site 1146883001174 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1146883001175 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1146883001176 peptide binding site [polypeptide binding]; other site 1146883001177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1146883001178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883001179 dimer interface [polypeptide binding]; other site 1146883001180 conserved gate region; other site 1146883001181 putative PBP binding loops; other site 1146883001182 ABC-ATPase subunit interface; other site 1146883001183 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1146883001184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883001185 dimer interface [polypeptide binding]; other site 1146883001186 conserved gate region; other site 1146883001187 putative PBP binding loops; other site 1146883001188 ABC-ATPase subunit interface; other site 1146883001189 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1146883001190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883001191 Walker A/P-loop; other site 1146883001192 ATP binding site [chemical binding]; other site 1146883001193 Q-loop/lid; other site 1146883001194 ABC transporter signature motif; other site 1146883001195 Walker B; other site 1146883001196 D-loop; other site 1146883001197 H-loop/switch region; other site 1146883001198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1146883001199 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1146883001200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883001201 Walker A/P-loop; other site 1146883001202 ATP binding site [chemical binding]; other site 1146883001203 Q-loop/lid; other site 1146883001204 ABC transporter signature motif; other site 1146883001205 Walker B; other site 1146883001206 D-loop; other site 1146883001207 H-loop/switch region; other site 1146883001208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1146883001209 Repair protein; Region: Repair_PSII; pfam04536 1146883001210 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1146883001211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883001212 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1146883001213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883001214 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1146883001215 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1146883001216 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1146883001217 Divergent AAA domain; Region: AAA_4; pfam04326 1146883001218 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1146883001219 Pirin; Region: Pirin; pfam02678 1146883001220 Pirin-related protein [General function prediction only]; Region: COG1741 1146883001221 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1146883001222 Pirin; Region: Pirin; pfam02678 1146883001223 Pirin-related protein [General function prediction only]; Region: COG1741 1146883001224 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1146883001225 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 1146883001226 putative active site [active] 1146883001227 redox center [active] 1146883001228 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1146883001229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883001230 ABC transporter; Region: ABC_tran_2; pfam12848 1146883001231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883001232 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1146883001233 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883001234 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1146883001235 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1146883001236 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1146883001237 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1146883001238 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883001239 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1146883001240 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1146883001241 2-isopropylmalate synthase; Validated; Region: PRK03739 1146883001242 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1146883001243 active site 1146883001244 catalytic residues [active] 1146883001245 metal binding site [ion binding]; metal-binding site 1146883001246 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1146883001247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883001248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883001249 non-specific DNA binding site [nucleotide binding]; other site 1146883001250 salt bridge; other site 1146883001251 sequence-specific DNA binding site [nucleotide binding]; other site 1146883001252 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1146883001253 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1146883001254 putative active site [active] 1146883001255 catalytic site [active] 1146883001256 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 1146883001257 putative active site [active] 1146883001258 catalytic site [active] 1146883001259 aspartate kinase; Reviewed; Region: PRK06635 1146883001260 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1146883001261 putative nucleotide binding site [chemical binding]; other site 1146883001262 putative catalytic residues [active] 1146883001263 putative Mg ion binding site [ion binding]; other site 1146883001264 putative aspartate binding site [chemical binding]; other site 1146883001265 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1146883001266 putative allosteric regulatory site; other site 1146883001267 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1146883001268 putative allosteric regulatory residue; other site 1146883001269 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1146883001270 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1146883001271 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1146883001272 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1146883001273 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883001274 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1146883001275 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883001276 putative active site [active] 1146883001277 putative metal binding site [ion binding]; other site 1146883001278 Yqey-like protein; Region: YqeY; cl17540 1146883001279 Transglycosylase; Region: Transgly; pfam00912 1146883001280 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1146883001281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1146883001282 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1146883001283 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1146883001284 P loop; other site 1146883001285 Nucleotide binding site [chemical binding]; other site 1146883001286 DTAP/Switch II; other site 1146883001287 Switch I; other site 1146883001288 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1146883001289 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1146883001290 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1146883001291 DTAP/Switch II; other site 1146883001292 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1146883001293 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1146883001294 homotrimer interaction site [polypeptide binding]; other site 1146883001295 putative active site [active] 1146883001296 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1146883001297 nudix motif; other site 1146883001298 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1146883001299 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1146883001300 ligand binding site [chemical binding]; other site 1146883001301 flexible hinge region; other site 1146883001302 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1146883001303 putative switch regulator; other site 1146883001304 non-specific DNA interactions [nucleotide binding]; other site 1146883001305 DNA binding site [nucleotide binding] 1146883001306 sequence specific DNA binding site [nucleotide binding]; other site 1146883001307 putative cAMP binding site [chemical binding]; other site 1146883001308 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1146883001309 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1146883001310 minor groove reading motif; other site 1146883001311 helix-hairpin-helix signature motif; other site 1146883001312 substrate binding pocket [chemical binding]; other site 1146883001313 active site 1146883001314 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1146883001315 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1146883001316 catalytic residues [active] 1146883001317 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1146883001318 putative active site [active] 1146883001319 putative CoA binding site [chemical binding]; other site 1146883001320 nudix motif; other site 1146883001321 metal binding site [ion binding]; metal-binding site 1146883001322 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1146883001323 Colicin V production protein; Region: Colicin_V; pfam02674 1146883001324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883001325 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1146883001326 acetyl-CoA synthetase; Provisional; Region: PRK00174 1146883001327 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1146883001328 active site 1146883001329 CoA binding site [chemical binding]; other site 1146883001330 acyl-activating enzyme (AAE) consensus motif; other site 1146883001331 AMP binding site [chemical binding]; other site 1146883001332 acetate binding site [chemical binding]; other site 1146883001333 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1146883001334 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1146883001335 putative active site [active] 1146883001336 metal binding site [ion binding]; metal-binding site 1146883001337 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1146883001338 active site 1146883001339 putative catalytic site [active] 1146883001340 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1146883001341 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1146883001342 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1146883001343 homodimer interface [polypeptide binding]; other site 1146883001344 active site 1146883001345 SAM binding site [chemical binding]; other site 1146883001346 hypothetical protein; Provisional; Region: PRK07908 1146883001347 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1146883001348 PemK-like protein; Region: PemK; pfam02452 1146883001349 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1146883001350 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1146883001351 cobyric acid synthase; Provisional; Region: PRK00784 1146883001352 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1146883001353 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1146883001354 catalytic triad [active] 1146883001355 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1146883001356 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1146883001357 putative acyl-acceptor binding pocket; other site 1146883001358 PAS fold; Region: PAS_3; pfam08447 1146883001359 ANTAR domain; Region: ANTAR; pfam03861 1146883001360 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1146883001361 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1146883001362 active site 1146883001363 catalytic residues [active] 1146883001364 metal binding site [ion binding]; metal-binding site 1146883001365 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883001366 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1146883001367 Integrase core domain; Region: rve; pfam00665 1146883001368 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 1146883001369 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1146883001370 oligomer interface; other site 1146883001371 ligand binding site; other site 1146883001372 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1146883001373 dimer interface [polypeptide binding]; other site 1146883001374 N-terminal domain interface [polypeptide binding]; other site 1146883001375 sulfate 1 binding site; other site 1146883001376 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1146883001377 Evidence 7 : Gene remnant 1146883001378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883001379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883001380 active site 1146883001381 catalytic tetrad [active] 1146883001382 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1146883001383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883001384 motif II; other site 1146883001385 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1146883001386 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1146883001387 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883001388 Walker A motif; other site 1146883001389 ATP binding site [chemical binding]; other site 1146883001390 Walker B motif; other site 1146883001391 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1146883001392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883001393 ATP binding site [chemical binding]; other site 1146883001394 putative Mg++ binding site [ion binding]; other site 1146883001395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883001396 nucleotide binding region [chemical binding]; other site 1146883001397 ATP-binding site [chemical binding]; other site 1146883001398 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1146883001399 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1146883001400 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1146883001401 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1146883001402 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1146883001403 active site 1146883001404 interdomain interaction site; other site 1146883001405 putative metal-binding site [ion binding]; other site 1146883001406 nucleotide binding site [chemical binding]; other site 1146883001407 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1146883001408 domain I; other site 1146883001409 phosphate binding site [ion binding]; other site 1146883001410 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1146883001411 domain II; other site 1146883001412 domain III; other site 1146883001413 nucleotide binding site [chemical binding]; other site 1146883001414 DNA binding groove [nucleotide binding] 1146883001415 catalytic site [active] 1146883001416 domain IV; other site 1146883001417 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1146883001418 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1146883001419 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1146883001420 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1146883001421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883001422 S-adenosylmethionine binding site [chemical binding]; other site 1146883001423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883001424 H+ Antiporter protein; Region: 2A0121; TIGR00900 1146883001425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883001426 putative substrate translocation pore; other site 1146883001427 thymidylate kinase; Validated; Region: tmk; PRK00698 1146883001428 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1146883001429 TMP-binding site; other site 1146883001430 ATP-binding site [chemical binding]; other site 1146883001431 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1146883001432 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1146883001433 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1146883001434 dimer interface [polypeptide binding]; other site 1146883001435 substrate binding site [chemical binding]; other site 1146883001436 metal binding sites [ion binding]; metal-binding site 1146883001437 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1146883001438 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1146883001439 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1146883001440 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1146883001441 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1146883001442 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1146883001443 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1146883001444 active site 1146883001445 FtsH Extracellular; Region: FtsH_ext; pfam06480 1146883001446 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1146883001447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883001448 Walker A motif; other site 1146883001449 ATP binding site [chemical binding]; other site 1146883001450 Walker B motif; other site 1146883001451 arginine finger; other site 1146883001452 Peptidase family M41; Region: Peptidase_M41; pfam01434 1146883001453 GTP cyclohydrolase I; Provisional; Region: PLN03044 1146883001454 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1146883001455 homodecamer interface [polypeptide binding]; other site 1146883001456 active site 1146883001457 putative catalytic site residues [active] 1146883001458 zinc binding site [ion binding]; other site 1146883001459 GTP-CH-I/GFRP interaction surface; other site 1146883001460 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1146883001461 dihydropteroate synthase; Region: DHPS; TIGR01496 1146883001462 substrate binding pocket [chemical binding]; other site 1146883001463 dimer interface [polypeptide binding]; other site 1146883001464 inhibitor binding site; inhibition site 1146883001465 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1146883001466 homooctamer interface [polypeptide binding]; other site 1146883001467 active site 1146883001468 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1146883001469 catalytic center binding site [active] 1146883001470 ATP binding site [chemical binding]; other site 1146883001471 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1146883001472 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1146883001473 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1146883001474 Walker A/P-loop; other site 1146883001475 ATP binding site [chemical binding]; other site 1146883001476 Q-loop/lid; other site 1146883001477 ABC transporter signature motif; other site 1146883001478 Walker B; other site 1146883001479 D-loop; other site 1146883001480 H-loop/switch region; other site 1146883001481 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1146883001482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883001483 dimer interface [polypeptide binding]; other site 1146883001484 conserved gate region; other site 1146883001485 ABC-ATPase subunit interface; other site 1146883001486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883001487 conserved gate region; other site 1146883001488 ABC-ATPase subunit interface; other site 1146883001489 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1146883001490 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1146883001491 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1146883001492 classical (c) SDRs; Region: SDR_c; cd05233 1146883001493 NAD(P) binding site [chemical binding]; other site 1146883001494 active site 1146883001495 Rossmann-like domain; Region: Rossmann-like; pfam10727 1146883001496 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1146883001497 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883001498 active site 1146883001499 nucleotide binding site [chemical binding]; other site 1146883001500 HIGH motif; other site 1146883001501 KMSKS motif; other site 1146883001502 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1146883001503 tetramerization interface [polypeptide binding]; other site 1146883001504 active site 1146883001505 pantothenate kinase; Reviewed; Region: PRK13318 1146883001506 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1146883001507 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1146883001508 dimer interface [polypeptide binding]; other site 1146883001509 putative anticodon binding site; other site 1146883001510 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1146883001511 motif 1; other site 1146883001512 dimer interface [polypeptide binding]; other site 1146883001513 active site 1146883001514 motif 2; other site 1146883001515 motif 3; other site 1146883001516 Lsr2; Region: Lsr2; pfam11774 1146883001517 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1146883001518 Clp amino terminal domain; Region: Clp_N; pfam02861 1146883001519 Clp amino terminal domain; Region: Clp_N; pfam02861 1146883001520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883001521 Walker A motif; other site 1146883001522 ATP binding site [chemical binding]; other site 1146883001523 Walker B motif; other site 1146883001524 arginine finger; other site 1146883001525 UvrB/uvrC motif; Region: UVR; pfam02151 1146883001526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883001527 Walker A motif; other site 1146883001528 ATP binding site [chemical binding]; other site 1146883001529 Walker B motif; other site 1146883001530 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1146883001531 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1146883001532 endonuclease III; Region: ENDO3c; smart00478 1146883001533 minor groove reading motif; other site 1146883001534 helix-hairpin-helix signature motif; other site 1146883001535 substrate binding pocket [chemical binding]; other site 1146883001536 active site 1146883001537 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1146883001538 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1146883001539 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1146883001540 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1146883001541 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1146883001542 DNA repair protein RadA; Provisional; Region: PRK11823 1146883001543 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883001544 Walker A motif; other site 1146883001545 ATP binding site [chemical binding]; other site 1146883001546 Walker B motif; other site 1146883001547 Protein of unknown function (DUF461); Region: DUF461; cl01071 1146883001548 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1146883001549 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1146883001550 Evidence 2b : Function of strongly homologous gene; PubMedId : 10694574; Product type e : enzyme 1146883001551 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1146883001552 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883001553 active site 1146883001554 HIGH motif; other site 1146883001555 nucleotide binding site [chemical binding]; other site 1146883001556 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1146883001557 KMSKS motif; other site 1146883001558 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1146883001559 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1146883001560 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1146883001561 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1146883001562 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1146883001563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1146883001564 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1146883001565 protein binding site [polypeptide binding]; other site 1146883001566 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883001567 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1146883001568 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1146883001569 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1146883001570 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883001571 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1146883001572 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883001573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883001574 Walker A/P-loop; other site 1146883001575 ATP binding site [chemical binding]; other site 1146883001576 Q-loop/lid; other site 1146883001577 ABC transporter signature motif; other site 1146883001578 Walker B; other site 1146883001579 D-loop; other site 1146883001580 H-loop/switch region; other site 1146883001581 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1146883001582 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1146883001583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883001584 active site 1146883001585 motif I; other site 1146883001586 motif II; other site 1146883001587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1146883001588 threonine synthase; Validated; Region: PRK07591 1146883001589 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1146883001590 homodimer interface [polypeptide binding]; other site 1146883001591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883001592 catalytic residue [active] 1146883001593 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1146883001594 DNA-binding site [nucleotide binding]; DNA binding site 1146883001595 RNA-binding motif; other site 1146883001596 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1146883001597 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1146883001598 ring oligomerisation interface [polypeptide binding]; other site 1146883001599 ATP/Mg binding site [chemical binding]; other site 1146883001600 stacking interactions; other site 1146883001601 hinge regions; other site 1146883001602 Protein of unknown function DUF72; Region: DUF72; pfam01904 1146883001603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883001604 NAD(P) binding site [chemical binding]; other site 1146883001605 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1146883001606 active site 1146883001607 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1146883001608 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1146883001609 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 1146883001610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1146883001611 acetylornithine deacetylase; Validated; Region: PRK06915 1146883001612 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1146883001613 metal binding site [ion binding]; metal-binding site 1146883001614 dimer interface [polypeptide binding]; other site 1146883001615 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1146883001616 Scramblase; Region: Scramblase; pfam03803 1146883001617 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1146883001618 oligomeric interface; other site 1146883001619 putative active site [active] 1146883001620 homodimer interface [polypeptide binding]; other site 1146883001621 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883001622 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1146883001623 ATP binding site [chemical binding]; other site 1146883001624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883001625 putative Mg++ binding site [ion binding]; other site 1146883001626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1146883001627 ATP-binding site [chemical binding]; other site 1146883001628 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1146883001629 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1146883001630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883001631 ATP binding site [chemical binding]; other site 1146883001632 putative Mg++ binding site [ion binding]; other site 1146883001633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883001634 nucleotide binding region [chemical binding]; other site 1146883001635 ATP-binding site [chemical binding]; other site 1146883001636 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1146883001637 WYL domain; Region: WYL; pfam13280 1146883001638 AMP-binding domain protein; Validated; Region: PRK08315 1146883001639 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883001640 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1146883001641 acyl-activating enzyme (AAE) consensus motif; other site 1146883001642 putative AMP binding site [chemical binding]; other site 1146883001643 putative active site [active] 1146883001644 putative CoA binding site [chemical binding]; other site 1146883001645 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883001646 putative catalytic site [active] 1146883001647 putative metal binding site [ion binding]; other site 1146883001648 putative phosphate binding site [ion binding]; other site 1146883001649 Domain of unknown function (DUF202); Region: DUF202; cl09954 1146883001650 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1146883001651 DNA-binding site [nucleotide binding]; DNA binding site 1146883001652 RNA-binding motif; other site 1146883001653 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1146883001654 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1146883001655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883001656 MarR family; Region: MarR; pfam01047 1146883001657 H+ Antiporter protein; Region: 2A0121; TIGR00900 1146883001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883001659 putative substrate translocation pore; other site 1146883001660 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1146883001661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883001662 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883001663 active site 1146883001664 catalytic tetrad [active] 1146883001665 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1146883001666 Evidence 7 : Gene remnant 1146883001667 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883001668 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1146883001669 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1146883001670 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1146883001671 Walker A/P-loop; other site 1146883001672 ATP binding site [chemical binding]; other site 1146883001673 Q-loop/lid; other site 1146883001674 ABC transporter signature motif; other site 1146883001675 Walker B; other site 1146883001676 D-loop; other site 1146883001677 H-loop/switch region; other site 1146883001678 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1146883001679 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1146883001680 Sporulation related domain; Region: SPOR; cl10051 1146883001681 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1146883001682 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1146883001683 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883001684 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883001685 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1146883001686 GAF domain; Region: GAF_3; pfam13492 1146883001687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883001688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883001689 dimer interface [polypeptide binding]; other site 1146883001690 phosphorylation site [posttranslational modification] 1146883001691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883001692 ATP binding site [chemical binding]; other site 1146883001693 Mg2+ binding site [ion binding]; other site 1146883001694 G-X-G motif; other site 1146883001695 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883001696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883001697 active site 1146883001698 phosphorylation site [posttranslational modification] 1146883001699 intermolecular recognition site; other site 1146883001700 dimerization interface [polypeptide binding]; other site 1146883001701 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883001702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883001703 Mg2+ binding site [ion binding]; other site 1146883001704 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883001705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883001706 catalytic residue [active] 1146883001707 citrate synthase 2; Provisional; Region: PRK12350 1146883001708 Citrate synthase; Region: Citrate_synt; pfam00285 1146883001709 oxalacetate binding site [chemical binding]; other site 1146883001710 citrylCoA binding site [chemical binding]; other site 1146883001711 coenzyme A binding site [chemical binding]; other site 1146883001712 catalytic triad [active] 1146883001713 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1146883001714 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1146883001715 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1146883001716 enterobactin exporter EntS; Provisional; Region: PRK10489 1146883001717 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1146883001718 Fe-S cluster binding site [ion binding]; other site 1146883001719 active site 1146883001720 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1146883001721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883001722 Walker A/P-loop; other site 1146883001723 ATP binding site [chemical binding]; other site 1146883001724 Q-loop/lid; other site 1146883001725 ABC transporter signature motif; other site 1146883001726 Walker B; other site 1146883001727 D-loop; other site 1146883001728 H-loop/switch region; other site 1146883001729 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1146883001730 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1146883001731 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1146883001732 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1146883001733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1146883001734 TPR motif; other site 1146883001735 binding surface 1146883001736 TPR repeat; Region: TPR_11; pfam13414 1146883001737 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1146883001738 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1146883001739 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1146883001740 active site 1146883001741 ferredoxin-NADP+ reductase; Region: PLN02852 1146883001742 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1146883001743 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883001744 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1146883001745 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1146883001746 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1146883001747 putative DNA binding site [nucleotide binding]; other site 1146883001748 catalytic residue [active] 1146883001749 putative H2TH interface [polypeptide binding]; other site 1146883001750 putative catalytic residues [active] 1146883001751 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1146883001752 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1146883001753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883001754 Coenzyme A binding pocket [chemical binding]; other site 1146883001755 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1146883001756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883001757 active site 1146883001758 DNA binding site [nucleotide binding] 1146883001759 Int/Topo IB signature motif; other site 1146883001760 TrwC relaxase; Region: TrwC; pfam08751 1146883001761 AAA domain; Region: AAA_30; pfam13604 1146883001762 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883001763 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883001764 metal binding site [ion binding]; metal-binding site 1146883001765 active site 1146883001766 I-site; other site 1146883001767 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883001768 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1146883001769 CGNR zinc finger; Region: zf-CGNR; pfam11706 1146883001770 Protein of unknown function DUF72; Region: DUF72; cl00777 1146883001771 PemK-like protein; Region: PemK; pfam02452 1146883001772 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1146883001773 catalytic nucleophile [active] 1146883001774 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1146883001775 Hemerythrin-like domain; Region: Hr-like; cd12108 1146883001776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 1146883001777 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1146883001778 Evidence 7 : Gene remnant 1146883001779 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1146883001780 CopC domain; Region: CopC; pfam04234 1146883001781 Copper resistance protein D; Region: CopD; pfam05425 1146883001782 Predicted integral membrane protein [Function unknown]; Region: COG5660 1146883001783 Putative zinc-finger; Region: zf-HC2; pfam13490 1146883001784 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1146883001785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883001786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883001787 DNA binding residues [nucleotide binding] 1146883001788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883001789 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1146883001790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1146883001791 dimerization interface [polypeptide binding]; other site 1146883001792 Lysine efflux permease [General function prediction only]; Region: COG1279 1146883001793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883001794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883001795 active site 1146883001796 phosphorylation site [posttranslational modification] 1146883001797 intermolecular recognition site; other site 1146883001798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883001799 DNA binding residues [nucleotide binding] 1146883001800 dimerization interface [polypeptide binding]; other site 1146883001801 Gag P30 core shell protein; Region: Gag_p30; pfam02093 1146883001802 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1146883001803 hydrophobic ligand binding site; other site 1146883001804 potential frameshift: common BLAST hit: gi|284989446|ref|YP_003408000.1| Silent information regulator protein Sir2 1146883001805 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1146883001806 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1146883001807 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883001808 CoenzymeA binding site [chemical binding]; other site 1146883001809 subunit interaction site [polypeptide binding]; other site 1146883001810 PHB binding site; other site 1146883001811 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1146883001812 active site 1146883001813 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1146883001814 putative deacylase active site [active] 1146883001815 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1146883001816 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1146883001817 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1146883001818 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1146883001819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883001820 CoenzymeA binding site [chemical binding]; other site 1146883001821 subunit interaction site [polypeptide binding]; other site 1146883001822 PHB binding site; other site 1146883001823 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883001824 MarR family; Region: MarR; pfam01047 1146883001825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1146883001826 Walker A/P-loop; other site 1146883001827 ATP binding site [chemical binding]; other site 1146883001828 Q-loop/lid; other site 1146883001829 ABC transporter signature motif; other site 1146883001830 Walker B; other site 1146883001831 D-loop; other site 1146883001832 H-loop/switch region; other site 1146883001833 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1146883001834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1146883001835 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1146883001836 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1146883001837 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1146883001838 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883001839 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883001840 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1146883001841 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1146883001842 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1146883001843 active site 1146883001844 tetramer interface; other site 1146883001845 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1146883001846 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1146883001847 dimer interface [polypeptide binding]; other site 1146883001848 putative functional site; other site 1146883001849 putative MPT binding site; other site 1146883001850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1146883001851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1146883001852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883001853 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1146883001854 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1146883001855 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1146883001856 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1146883001857 Predicted methyltransferases [General function prediction only]; Region: COG0313 1146883001858 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1146883001859 putative SAM binding site [chemical binding]; other site 1146883001860 putative homodimer interface [polypeptide binding]; other site 1146883001861 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1146883001862 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1146883001863 putative active site [active] 1146883001864 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1146883001865 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1146883001866 oligomer interface [polypeptide binding]; other site 1146883001867 metal binding site [ion binding]; metal-binding site 1146883001868 metal binding site [ion binding]; metal-binding site 1146883001869 putative Cl binding site [ion binding]; other site 1146883001870 basic sphincter; other site 1146883001871 hydrophobic gate; other site 1146883001872 periplasmic entrance; other site 1146883001873 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1146883001874 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1146883001875 active site 1146883001876 HIGH motif; other site 1146883001877 KMSKS motif; other site 1146883001878 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1146883001879 tRNA binding surface [nucleotide binding]; other site 1146883001880 anticodon binding site; other site 1146883001881 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1146883001882 active site 1146883001883 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1146883001884 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1146883001885 G5 domain; Region: G5; pfam07501 1146883001886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1146883001887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1146883001888 catalytic residue [active] 1146883001889 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1146883001890 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1146883001891 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1146883001892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883001893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883001894 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1146883001895 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1146883001896 Di-iron ligands [ion binding]; other site 1146883001897 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1146883001898 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1146883001899 Substrate binding site; other site 1146883001900 Mg++ binding site; other site 1146883001901 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1146883001902 active site 1146883001903 substrate binding site [chemical binding]; other site 1146883001904 CoA binding site [chemical binding]; other site 1146883001905 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1146883001906 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1146883001907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1146883001908 active site 1146883001909 Evidence 7 : Gene remnant 1146883001910 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1146883001911 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1146883001912 5S rRNA interface [nucleotide binding]; other site 1146883001913 CTC domain interface [polypeptide binding]; other site 1146883001914 L16 interface [polypeptide binding]; other site 1146883001915 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1146883001916 putative active site [active] 1146883001917 catalytic residue [active] 1146883001918 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1146883001919 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1146883001920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883001921 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1146883001922 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1146883001923 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1146883001924 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1146883001925 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1146883001926 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1146883001927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883001928 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883001929 Chain length determinant protein; Region: Wzz; pfam02706 1146883001930 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883001931 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1146883001932 active site 1146883001933 nucleotide binding site [chemical binding]; other site 1146883001934 HIGH motif; other site 1146883001935 KMSKS motif; other site 1146883001936 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1146883001937 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1146883001938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883001939 ATP binding site [chemical binding]; other site 1146883001940 putative Mg++ binding site [ion binding]; other site 1146883001941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883001942 nucleotide binding region [chemical binding]; other site 1146883001943 ATP-binding site [chemical binding]; other site 1146883001944 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1146883001945 SurA N-terminal domain; Region: SurA_N_3; cl07813 1146883001946 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1146883001947 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1146883001948 homodimer interface [polypeptide binding]; other site 1146883001949 metal binding site [ion binding]; metal-binding site 1146883001950 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1146883001951 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1146883001952 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1146883001953 Evidence 6 : Doubtful CDS 1146883001954 enolase; Provisional; Region: eno; PRK00077 1146883001955 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1146883001956 dimer interface [polypeptide binding]; other site 1146883001957 metal binding site [ion binding]; metal-binding site 1146883001958 substrate binding pocket [chemical binding]; other site 1146883001959 Septum formation initiator; Region: DivIC; pfam04977 1146883001960 Protein of unknown function (DUF501); Region: DUF501; cl00652 1146883001961 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1146883001962 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1146883001963 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1146883001964 Fe-S cluster binding site [ion binding]; other site 1146883001965 DNA binding site [nucleotide binding] 1146883001966 active site 1146883001967 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1146883001968 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1146883001969 PA/protease or protease-like domain interface [polypeptide binding]; other site 1146883001970 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1146883001971 Peptidase family M28; Region: Peptidase_M28; pfam04389 1146883001972 active site 1146883001973 metal binding site [ion binding]; metal-binding site 1146883001974 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1146883001975 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1146883001976 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883001977 dimer interface [polypeptide binding]; other site 1146883001978 active site 1146883001979 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1146883001980 active site 1146883001981 catalytic triad [active] 1146883001982 oxyanion hole [active] 1146883001983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1146883001984 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1146883001985 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1146883001986 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1146883001987 metal ion-dependent adhesion site (MIDAS); other site 1146883001988 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1146883001989 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1146883001990 threonine dehydratase; Provisional; Region: PRK08198 1146883001991 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1146883001992 tetramer interface [polypeptide binding]; other site 1146883001993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883001994 catalytic residue [active] 1146883001995 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1146883001996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883001997 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1146883001998 Walker A/P-loop; other site 1146883001999 ATP binding site [chemical binding]; other site 1146883002000 Q-loop/lid; other site 1146883002001 ABC transporter signature motif; other site 1146883002002 Walker B; other site 1146883002003 D-loop; other site 1146883002004 H-loop/switch region; other site 1146883002005 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1146883002006 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883002007 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1146883002008 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1146883002009 active site 1146883002010 Zn binding site [ion binding]; other site 1146883002011 RNHCP domain; Region: RNHCP; pfam12647 1146883002012 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1146883002013 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1146883002014 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1146883002015 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1146883002016 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1146883002017 sugar binding site [chemical binding]; other site 1146883002018 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1146883002019 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1146883002020 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1146883002021 Evidence 6 : Doubtful CDS 1146883002022 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883002023 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1146883002024 nucleophilic elbow; other site 1146883002025 catalytic triad; other site 1146883002026 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 1146883002027 redox center [active] 1146883002028 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1146883002029 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1146883002030 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1146883002031 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1146883002032 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1146883002033 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1146883002034 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1146883002035 catalytic residue [active] 1146883002036 putative FPP diphosphate binding site; other site 1146883002037 putative FPP binding hydrophobic cleft; other site 1146883002038 dimer interface [polypeptide binding]; other site 1146883002039 putative IPP diphosphate binding site; other site 1146883002040 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1146883002041 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1146883002042 putative active site [active] 1146883002043 PhoH-like protein; Region: PhoH; pfam02562 1146883002044 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1146883002045 FHIPEP family; Region: FHIPEP; pfam00771 1146883002046 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1146883002047 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1146883002048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1146883002049 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1146883002050 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1146883002051 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1146883002052 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1146883002053 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1146883002054 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1146883002055 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1146883002056 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1146883002057 Flagellar motor switch protein FliM; Region: FliM; pfam02154 1146883002058 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1146883002059 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1146883002060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1146883002061 ligand binding site [chemical binding]; other site 1146883002062 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1146883002063 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1146883002064 Flagellar protein (FlbD); Region: FlbD; pfam06289 1146883002065 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1146883002066 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1146883002067 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1146883002068 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1146883002069 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1146883002070 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1146883002071 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883002072 NlpC/P60 family; Region: NLPC_P60; pfam00877 1146883002073 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1146883002074 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1146883002075 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1146883002076 catalytic residue [active] 1146883002077 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1146883002078 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1146883002079 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1146883002080 Walker A motif/ATP binding site; other site 1146883002081 Walker B motif; other site 1146883002082 Flagellar assembly protein FliH; Region: FliH; pfam02108 1146883002083 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1146883002084 FliG C-terminal domain; Region: FliG_C; pfam01706 1146883002085 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1146883002086 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1146883002087 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1146883002088 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1146883002089 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1146883002090 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1146883002091 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 1146883002092 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1146883002093 Flagellar protein FliS; Region: FliS; cl00654 1146883002094 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1146883002095 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1146883002096 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1146883002097 flagellin; Provisional; Region: PRK12804 1146883002098 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1146883002099 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1146883002100 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1146883002101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883002102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883002103 DNA binding residues [nucleotide binding] 1146883002104 FlgN protein; Region: FlgN; pfam05130 1146883002105 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1146883002106 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1146883002107 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1146883002108 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1146883002109 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1146883002110 FliW protein; Region: FliW; pfam02623 1146883002111 Global regulator protein family; Region: CsrA; pfam02599 1146883002112 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1146883002113 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883002114 NlpC/P60 family; Region: NLPC_P60; cl17555 1146883002115 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1146883002116 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1146883002117 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1146883002118 dimer interface [polypeptide binding]; other site 1146883002119 active site 1146883002120 citrylCoA binding site [chemical binding]; other site 1146883002121 NADH binding [chemical binding]; other site 1146883002122 cationic pore residues; other site 1146883002123 oxalacetate/citrate binding site [chemical binding]; other site 1146883002124 coenzyme A binding site [chemical binding]; other site 1146883002125 catalytic triad [active] 1146883002126 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1146883002127 Class II fumarases; Region: Fumarase_classII; cd01362 1146883002128 active site 1146883002129 tetramer interface [polypeptide binding]; other site 1146883002130 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1146883002131 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1146883002132 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1146883002133 putative active site [active] 1146883002134 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1146883002135 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1146883002136 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1146883002137 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1146883002138 generic binding surface II; other site 1146883002139 generic binding surface I; other site 1146883002140 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1146883002141 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1146883002142 RmuC family; Region: RmuC; pfam02646 1146883002143 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1146883002144 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1146883002145 DNA binding site [nucleotide binding] 1146883002146 active site 1146883002147 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1146883002148 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1146883002149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1146883002150 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1146883002151 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1146883002152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1146883002153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883002154 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1146883002155 Walker A/P-loop; other site 1146883002156 ATP binding site [chemical binding]; other site 1146883002157 Q-loop/lid; other site 1146883002158 ABC transporter signature motif; other site 1146883002159 Walker B; other site 1146883002160 D-loop; other site 1146883002161 H-loop/switch region; other site 1146883002162 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883002163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883002164 Histidine kinase; Region: HisKA_3; pfam07730 1146883002165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883002166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002168 active site 1146883002169 phosphorylation site [posttranslational modification] 1146883002170 intermolecular recognition site; other site 1146883002171 dimerization interface [polypeptide binding]; other site 1146883002172 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002173 DNA binding residues [nucleotide binding] 1146883002174 dimerization interface [polypeptide binding]; other site 1146883002175 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1146883002176 active site 1146883002177 catalytic triad [active] 1146883002178 oxyanion hole [active] 1146883002179 GTP-binding protein YchF; Reviewed; Region: PRK09601 1146883002180 YchF GTPase; Region: YchF; cd01900 1146883002181 G1 box; other site 1146883002182 GTP/Mg2+ binding site [chemical binding]; other site 1146883002183 Switch I region; other site 1146883002184 G2 box; other site 1146883002185 Switch II region; other site 1146883002186 G3 box; other site 1146883002187 G4 box; other site 1146883002188 G5 box; other site 1146883002189 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1146883002190 integrase; Provisional; Region: int; PHA02601 1146883002191 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1146883002192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883002193 active site 1146883002194 DNA binding site [nucleotide binding] 1146883002195 Int/Topo IB signature motif; other site 1146883002196 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1146883002197 putative active site [active] 1146883002198 Fip1 motif; Region: Fip1; cl02162 1146883002199 AAA ATPase domain; Region: AAA_16; pfam13191 1146883002200 AAA domain; Region: AAA_22; pfam13401 1146883002201 Zinc-binding dehydrogenase; Region: ADH_zinc_N_2; pfam13602 1146883002202 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1146883002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1146883002204 Predicted transcriptional regulators [Transcription]; Region: COG1733 1146883002205 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1146883002206 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883002207 CoenzymeA binding site [chemical binding]; other site 1146883002208 subunit interaction site [polypeptide binding]; other site 1146883002209 PHB binding site; other site 1146883002210 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1146883002211 Integrase core domain; Region: rve; pfam00665 1146883002212 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883002213 TrwC relaxase; Region: TrwC; pfam08751 1146883002214 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883002215 AAA domain; Region: AAA_30; pfam13604 1146883002216 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1146883002217 RibD C-terminal domain; Region: RibD_C; cl17279 1146883002218 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1146883002219 SnoaL-like domain; Region: SnoaL_2; pfam12680 1146883002220 PspC domain; Region: PspC; pfam04024 1146883002221 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1146883002222 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883002223 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1146883002224 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1146883002225 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883002226 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1146883002227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883002228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883002229 metal binding site [ion binding]; metal-binding site 1146883002230 active site 1146883002231 I-site; other site 1146883002232 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883002233 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1146883002234 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1146883002235 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1146883002236 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1146883002237 L-aspartate oxidase; Provisional; Region: PRK06175 1146883002238 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1146883002239 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1146883002240 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1146883002241 putative Iron-sulfur protein interface [polypeptide binding]; other site 1146883002242 proximal heme binding site [chemical binding]; other site 1146883002243 distal heme binding site [chemical binding]; other site 1146883002244 putative dimer interface [polypeptide binding]; other site 1146883002245 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1146883002246 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1146883002247 Moco binding site; other site 1146883002248 metal coordination site [ion binding]; other site 1146883002249 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1146883002250 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1146883002251 FAD binding pocket [chemical binding]; other site 1146883002252 conserved FAD binding motif [chemical binding]; other site 1146883002253 phosphate binding motif [ion binding]; other site 1146883002254 beta-alpha-beta structure motif; other site 1146883002255 NAD binding pocket [chemical binding]; other site 1146883002256 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1146883002257 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1146883002258 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883002259 metal binding site [ion binding]; metal-binding site 1146883002260 active site 1146883002261 I-site; other site 1146883002262 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883002263 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1146883002264 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1146883002265 aromatic arch; other site 1146883002266 DCoH dimer interaction site [polypeptide binding]; other site 1146883002267 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1146883002268 DCoH tetramer interaction site [polypeptide binding]; other site 1146883002269 substrate binding site [chemical binding]; other site 1146883002270 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1146883002271 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1146883002272 Active Sites [active] 1146883002273 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1146883002274 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1146883002275 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1146883002276 Predicted transcriptional regulator [Transcription]; Region: COG1959 1146883002277 Transcriptional regulator; Region: Rrf2; pfam02082 1146883002278 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1146883002279 active site 1146883002280 nudix motif; other site 1146883002281 metal binding site [ion binding]; metal-binding site 1146883002282 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1146883002283 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1146883002284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1146883002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883002286 dimer interface [polypeptide binding]; other site 1146883002287 conserved gate region; other site 1146883002288 putative PBP binding loops; other site 1146883002289 ABC-ATPase subunit interface; other site 1146883002290 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1146883002291 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1146883002292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883002293 putative PBP binding loops; other site 1146883002294 dimer interface [polypeptide binding]; other site 1146883002295 ABC-ATPase subunit interface; other site 1146883002296 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1146883002297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883002298 Walker A/P-loop; other site 1146883002299 ATP binding site [chemical binding]; other site 1146883002300 Q-loop/lid; other site 1146883002301 ABC transporter signature motif; other site 1146883002302 Walker B; other site 1146883002303 D-loop; other site 1146883002304 H-loop/switch region; other site 1146883002305 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1146883002306 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1146883002307 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883002308 Walker A/P-loop; other site 1146883002309 ATP binding site [chemical binding]; other site 1146883002310 Q-loop/lid; other site 1146883002311 ABC transporter signature motif; other site 1146883002312 Walker B; other site 1146883002313 D-loop; other site 1146883002314 H-loop/switch region; other site 1146883002315 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1146883002316 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1146883002317 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883002318 GAF domain; Region: GAF_3; pfam13492 1146883002319 GAF domain; Region: GAF; cl17456 1146883002320 GAF domain; Region: GAF_2; pfam13185 1146883002321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883002322 metal binding site [ion binding]; metal-binding site 1146883002323 active site 1146883002324 I-site; other site 1146883002325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883002326 Ferredoxin [Energy production and conversion]; Region: COG1146 1146883002327 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883002328 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1146883002329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883002330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883002331 homodimer interface [polypeptide binding]; other site 1146883002332 catalytic residue [active] 1146883002333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002335 active site 1146883002336 phosphorylation site [posttranslational modification] 1146883002337 intermolecular recognition site; other site 1146883002338 dimerization interface [polypeptide binding]; other site 1146883002339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002340 DNA binding residues [nucleotide binding] 1146883002341 dimerization interface [polypeptide binding]; other site 1146883002342 Histidine kinase; Region: HisKA_3; pfam07730 1146883002343 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883002344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883002345 ATP binding site [chemical binding]; other site 1146883002346 Mg2+ binding site [ion binding]; other site 1146883002347 G-X-G motif; other site 1146883002348 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1146883002349 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1146883002350 putative trimer interface [polypeptide binding]; other site 1146883002351 putative CoA binding site [chemical binding]; other site 1146883002352 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1146883002353 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1146883002354 metal binding site [ion binding]; metal-binding site 1146883002355 putative dimer interface [polypeptide binding]; other site 1146883002356 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1146883002357 DivIVA domain; Region: DivI1A_domain; TIGR03544 1146883002358 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1146883002359 hydrophobic ligand binding site; other site 1146883002360 EamA-like transporter family; Region: EamA; pfam00892 1146883002361 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1146883002362 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1146883002363 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1146883002364 phytoene desaturase; Region: crtI_fam; TIGR02734 1146883002365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883002366 PAS domain; Region: PAS_9; pfam13426 1146883002367 putative active site [active] 1146883002368 heme pocket [chemical binding]; other site 1146883002369 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1146883002370 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883002371 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1146883002372 putative active site [active] 1146883002373 ANTAR domain; Region: ANTAR; cl04297 1146883002374 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1146883002375 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1146883002376 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1146883002377 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1146883002378 Walker A/P-loop; other site 1146883002379 ATP binding site [chemical binding]; other site 1146883002380 Q-loop/lid; other site 1146883002381 ABC transporter signature motif; other site 1146883002382 Walker B; other site 1146883002383 D-loop; other site 1146883002384 H-loop/switch region; other site 1146883002385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1146883002386 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1146883002387 putative PBP binding regions; other site 1146883002388 ABC-ATPase subunit interface; other site 1146883002389 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1146883002390 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1146883002391 putative binding site residues; other site 1146883002392 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1146883002393 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883002394 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1146883002395 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1146883002396 ligand binding site; other site 1146883002397 oligomer interface; other site 1146883002398 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1146883002399 dimer interface [polypeptide binding]; other site 1146883002400 N-terminal domain interface [polypeptide binding]; other site 1146883002401 sulfate 1 binding site; other site 1146883002402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883002403 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1146883002404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883002405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883002406 DNA binding residues [nucleotide binding] 1146883002407 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1146883002408 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1146883002409 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1146883002410 protein binding site [polypeptide binding]; other site 1146883002411 sec-independent translocase; Provisional; Region: PRK01371 1146883002412 Domain of unknown function DUF59; Region: DUF59; cl00941 1146883002413 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1146883002414 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1146883002415 AzlC protein; Region: AzlC; pfam03591 1146883002416 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1146883002417 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1146883002418 MgtE intracellular N domain; Region: MgtE_N; smart00924 1146883002419 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1146883002420 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1146883002421 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1146883002422 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1146883002423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883002424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883002425 active site 1146883002426 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1146883002427 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883002428 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1146883002429 putative NAD(P) binding site [chemical binding]; other site 1146883002430 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1146883002431 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1146883002432 phosphopeptide binding site; other site 1146883002433 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1146883002434 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1146883002435 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1146883002436 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1146883002437 EthD domain; Region: EthD; cl17553 1146883002438 hypothetical protein; Validated; Region: PRK07586 1146883002439 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1146883002440 PYR/PP interface [polypeptide binding]; other site 1146883002441 dimer interface [polypeptide binding]; other site 1146883002442 TPP binding site [chemical binding]; other site 1146883002443 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1146883002444 TPP-binding site [chemical binding]; other site 1146883002445 dimer interface [polypeptide binding]; other site 1146883002446 Transmembrane secretion effector; Region: MFS_3; pfam05977 1146883002447 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1146883002448 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1146883002449 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1146883002450 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1146883002451 ATP binding site [chemical binding]; other site 1146883002452 Walker A motif; other site 1146883002453 hexamer interface [polypeptide binding]; other site 1146883002454 Walker B motif; other site 1146883002455 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1146883002456 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1146883002457 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1146883002458 Na binding site [ion binding]; other site 1146883002459 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1146883002460 nucleoside/Zn binding site; other site 1146883002461 dimer interface [polypeptide binding]; other site 1146883002462 catalytic motif [active] 1146883002463 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1146883002464 Histidine kinase; Region: HisKA_3; pfam07730 1146883002465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002467 active site 1146883002468 phosphorylation site [posttranslational modification] 1146883002469 intermolecular recognition site; other site 1146883002470 dimerization interface [polypeptide binding]; other site 1146883002471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002472 DNA binding residues [nucleotide binding] 1146883002473 dimerization interface [polypeptide binding]; other site 1146883002474 Lipase (class 2); Region: Lipase_2; pfam01674 1146883002475 PAS fold; Region: PAS; pfam00989 1146883002476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883002477 metal binding site [ion binding]; metal-binding site 1146883002478 active site 1146883002479 I-site; other site 1146883002480 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883002481 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1146883002482 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1146883002483 RF-1 domain; Region: RF-1; pfam00472 1146883002484 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1146883002485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883002486 Walker A/P-loop; other site 1146883002487 ATP binding site [chemical binding]; other site 1146883002488 Q-loop/lid; other site 1146883002489 ABC transporter signature motif; other site 1146883002490 Walker B; other site 1146883002491 D-loop; other site 1146883002492 H-loop/switch region; other site 1146883002493 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1146883002494 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1146883002495 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1146883002496 SmpB-tmRNA interface; other site 1146883002497 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883002498 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1146883002499 putative NAD(P) binding site [chemical binding]; other site 1146883002500 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1146883002501 active site 1146883002502 active site 1146883002503 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1146883002504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883002505 Coenzyme A binding pocket [chemical binding]; other site 1146883002506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1146883002507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883002508 Coenzyme A binding pocket [chemical binding]; other site 1146883002509 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1146883002510 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1146883002511 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1146883002512 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1146883002513 oligomer interface [polypeptide binding]; other site 1146883002514 metal binding site [ion binding]; metal-binding site 1146883002515 metal binding site [ion binding]; metal-binding site 1146883002516 putative Cl binding site [ion binding]; other site 1146883002517 basic sphincter; other site 1146883002518 hydrophobic gate; other site 1146883002519 periplasmic entrance; other site 1146883002520 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1146883002521 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1146883002522 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1146883002523 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1146883002524 Family description; Region: UvrD_C_2; pfam13538 1146883002525 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1146883002526 AAA domain; Region: AAA_30; pfam13604 1146883002527 Family description; Region: UvrD_C_2; pfam13538 1146883002528 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1146883002529 Na2 binding site [ion binding]; other site 1146883002530 putative substrate binding site 1 [chemical binding]; other site 1146883002531 Na binding site 1 [ion binding]; other site 1146883002532 putative substrate binding site 2 [chemical binding]; other site 1146883002533 maltose O-acetyltransferase; Provisional; Region: PRK10092 1146883002534 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1146883002535 active site 1146883002536 substrate binding site [chemical binding]; other site 1146883002537 trimer interface [polypeptide binding]; other site 1146883002538 CoA binding site [chemical binding]; other site 1146883002539 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1146883002540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883002541 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883002542 CoenzymeA binding site [chemical binding]; other site 1146883002543 subunit interaction site [polypeptide binding]; other site 1146883002544 PHB binding site; other site 1146883002545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883002546 dimerization interface [polypeptide binding]; other site 1146883002547 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1146883002548 cyclase homology domain; Region: CHD; cd07302 1146883002549 nucleotidyl binding site; other site 1146883002550 metal binding site [ion binding]; metal-binding site 1146883002551 dimer interface [polypeptide binding]; other site 1146883002552 Ion channel; Region: Ion_trans_2; pfam07885 1146883002553 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1146883002554 TrkA-N domain; Region: TrkA_N; pfam02254 1146883002555 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1146883002556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883002557 acyl-activating enzyme (AAE) consensus motif; other site 1146883002558 AMP binding site [chemical binding]; other site 1146883002559 active site 1146883002560 CoA binding site [chemical binding]; other site 1146883002561 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1146883002562 active site 1146883002563 nucleophile elbow; other site 1146883002564 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1146883002565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883002566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883002567 ATP binding site [chemical binding]; other site 1146883002568 Mg2+ binding site [ion binding]; other site 1146883002569 G-X-G motif; other site 1146883002570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002572 active site 1146883002573 phosphorylation site [posttranslational modification] 1146883002574 intermolecular recognition site; other site 1146883002575 dimerization interface [polypeptide binding]; other site 1146883002576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002577 DNA binding residues [nucleotide binding] 1146883002578 dimerization interface [polypeptide binding]; other site 1146883002579 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1146883002580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883002581 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1146883002582 acyl-activating enzyme (AAE) consensus motif; other site 1146883002583 acyl-activating enzyme (AAE) consensus motif; other site 1146883002584 putative AMP binding site [chemical binding]; other site 1146883002585 putative active site [active] 1146883002586 putative CoA binding site [chemical binding]; other site 1146883002587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883002588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883002589 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883002590 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883002591 active site 1146883002592 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1146883002593 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1146883002594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883002595 active site 1146883002596 enoyl-CoA hydratase; Provisional; Region: PRK08260 1146883002597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883002598 substrate binding site [chemical binding]; other site 1146883002599 oxyanion hole (OAH) forming residues; other site 1146883002600 trimer interface [polypeptide binding]; other site 1146883002601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002603 active site 1146883002604 phosphorylation site [posttranslational modification] 1146883002605 intermolecular recognition site; other site 1146883002606 dimerization interface [polypeptide binding]; other site 1146883002607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002608 DNA binding residues [nucleotide binding] 1146883002609 dimerization interface [polypeptide binding]; other site 1146883002610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883002611 Histidine kinase; Region: HisKA_3; pfam07730 1146883002612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883002613 ATP binding site [chemical binding]; other site 1146883002614 Mg2+ binding site [ion binding]; other site 1146883002615 G-X-G motif; other site 1146883002616 Histidine kinase; Region: HisKA_3; pfam07730 1146883002617 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1146883002618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002620 active site 1146883002621 phosphorylation site [posttranslational modification] 1146883002622 intermolecular recognition site; other site 1146883002623 dimerization interface [polypeptide binding]; other site 1146883002624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002625 DNA binding residues [nucleotide binding] 1146883002626 dimerization interface [polypeptide binding]; other site 1146883002627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883002628 MarR family; Region: MarR_2; pfam12802 1146883002629 MarR family; Region: MarR_2; cl17246 1146883002630 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1146883002631 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1146883002632 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1146883002633 G1 box; other site 1146883002634 putative GEF interaction site [polypeptide binding]; other site 1146883002635 GTP/Mg2+ binding site [chemical binding]; other site 1146883002636 Switch I region; other site 1146883002637 G2 box; other site 1146883002638 G3 box; other site 1146883002639 Switch II region; other site 1146883002640 G4 box; other site 1146883002641 G5 box; other site 1146883002642 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1146883002643 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1146883002644 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1146883002645 hypothetical protein; Provisional; Region: PRK10621 1146883002646 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1146883002647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883002648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883002649 DNA binding residues [nucleotide binding] 1146883002650 Putative zinc-finger; Region: zf-HC2; pfam13490 1146883002651 CopC domain; Region: CopC; pfam04234 1146883002652 YtkA-like; Region: YtkA; pfam13115 1146883002653 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1146883002654 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1146883002655 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1146883002656 Cu(I) binding site [ion binding]; other site 1146883002657 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1146883002658 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1146883002659 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1146883002660 active site 1146883002661 metal-binding site 1146883002662 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883002663 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883002664 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1146883002665 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1146883002666 Int/Topo IB signature motif; other site 1146883002667 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883002668 MULE transposase domain; Region: MULE; pfam10551 1146883002669 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883002670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883002671 Walker A motif; other site 1146883002672 ATP binding site [chemical binding]; other site 1146883002673 Walker B motif; other site 1146883002674 Integrase core domain; Region: rve; pfam00665 1146883002675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1146883002676 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1146883002677 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1146883002678 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1146883002679 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883002680 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1146883002681 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1146883002682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883002683 non-specific DNA binding site [nucleotide binding]; other site 1146883002684 salt bridge; other site 1146883002685 sequence-specific DNA binding site [nucleotide binding]; other site 1146883002686 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1146883002687 active site 1146883002688 NTP binding site [chemical binding]; other site 1146883002689 metal binding triad [ion binding]; metal-binding site 1146883002690 antibiotic binding site [chemical binding]; other site 1146883002691 Protein of unknown function DUF86; Region: DUF86; pfam01934 1146883002692 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883002693 Int/Topo IB signature motif; other site 1146883002694 DNA binding site [nucleotide binding] 1146883002695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883002696 DNA-binding site [nucleotide binding]; DNA binding site 1146883002697 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883002698 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1146883002699 Walker A/P-loop; other site 1146883002700 ATP binding site [chemical binding]; other site 1146883002701 Q-loop/lid; other site 1146883002702 ABC transporter signature motif; other site 1146883002703 Walker B; other site 1146883002704 D-loop; other site 1146883002705 H-loop/switch region; other site 1146883002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883002707 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1146883002708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883002709 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1146883002710 DNA binding residues [nucleotide binding] 1146883002711 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1146883002712 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883002713 MerR, DNA binding; Region: MerR-DNA-bind; pfam09278 1146883002714 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1146883002715 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1146883002716 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1146883002717 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1146883002718 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1146883002719 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1146883002720 active site 1146883002721 dimer interface [polypeptide binding]; other site 1146883002722 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1146883002723 dimer interface [polypeptide binding]; other site 1146883002724 active site 1146883002725 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1146883002726 active site 1146883002727 catalytic triad [active] 1146883002728 oxyanion hole [active] 1146883002729 Flagellar protein (FlbD); Region: FlbD; cl00683 1146883002730 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1146883002731 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1146883002732 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883002733 DNA binding residues [nucleotide binding] 1146883002734 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1146883002735 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1146883002736 FAD binding pocket [chemical binding]; other site 1146883002737 FAD binding motif [chemical binding]; other site 1146883002738 phosphate binding motif [ion binding]; other site 1146883002739 NAD binding pocket [chemical binding]; other site 1146883002740 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1146883002741 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1146883002742 siderophore binding site; other site 1146883002743 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1146883002744 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1146883002745 heme binding site [chemical binding]; other site 1146883002746 ferroxidase pore; other site 1146883002747 ferroxidase diiron center [ion binding]; other site 1146883002748 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1146883002749 acyl-coenzyme A oxidase; Region: PLN02526 1146883002750 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883002751 active site 1146883002752 Evidence 7 : Gene remnant 1146883002753 Evidence 7 : Gene remnant 1146883002754 Evidence 7 : Gene remnant 1146883002755 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 1146883002756 Evidence 7 : Gene remnant 1146883002757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002758 active site 1146883002759 phosphorylation site [posttranslational modification] 1146883002760 intermolecular recognition site; other site 1146883002761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883002762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002763 active site 1146883002764 phosphorylation site [posttranslational modification] 1146883002765 intermolecular recognition site; other site 1146883002766 dimerization interface [polypeptide binding]; other site 1146883002767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883002768 DNA binding site [nucleotide binding] 1146883002769 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002771 active site 1146883002772 phosphorylation site [posttranslational modification] 1146883002773 intermolecular recognition site; other site 1146883002774 dimerization interface [polypeptide binding]; other site 1146883002775 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1146883002776 Catalytic site [active] 1146883002777 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1146883002778 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1146883002779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883002780 putative active site [active] 1146883002781 heme pocket [chemical binding]; other site 1146883002782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883002783 dimer interface [polypeptide binding]; other site 1146883002784 phosphorylation site [posttranslational modification] 1146883002785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883002786 ATP binding site [chemical binding]; other site 1146883002787 Mg2+ binding site [ion binding]; other site 1146883002788 G-X-G motif; other site 1146883002789 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1146883002790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883002791 active site 1146883002792 phosphorylation site [posttranslational modification] 1146883002793 intermolecular recognition site; other site 1146883002794 dimerization interface [polypeptide binding]; other site 1146883002795 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1146883002796 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1146883002797 enoyl-CoA hydratase; Provisional; Region: PRK06127 1146883002798 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883002799 substrate binding site [chemical binding]; other site 1146883002800 oxyanion hole (OAH) forming residues; other site 1146883002801 trimer interface [polypeptide binding]; other site 1146883002802 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1146883002803 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1146883002804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883002805 S-adenosylmethionine binding site [chemical binding]; other site 1146883002806 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1146883002807 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1146883002808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883002809 Walker A/P-loop; other site 1146883002810 ATP binding site [chemical binding]; other site 1146883002811 Q-loop/lid; other site 1146883002812 ABC transporter signature motif; other site 1146883002813 Walker B; other site 1146883002814 D-loop; other site 1146883002815 H-loop/switch region; other site 1146883002816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883002817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883002818 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883002819 active site 1146883002820 catalytic tetrad [active] 1146883002821 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1146883002822 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883002823 NAD binding site [chemical binding]; other site 1146883002824 catalytic Zn binding site [ion binding]; other site 1146883002825 structural Zn binding site [ion binding]; other site 1146883002826 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883002827 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883002828 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1146883002829 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1146883002830 active site 1146883002831 metal binding site [ion binding]; metal-binding site 1146883002832 homotetramer interface [polypeptide binding]; other site 1146883002833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883002834 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1146883002835 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1146883002836 D-pathway; other site 1146883002837 Putative ubiquinol binding site [chemical binding]; other site 1146883002838 Low-spin heme (heme b) binding site [chemical binding]; other site 1146883002839 Putative water exit pathway; other site 1146883002840 Binuclear center (heme o3/CuB) [ion binding]; other site 1146883002841 K-pathway; other site 1146883002842 Putative proton exit pathway; other site 1146883002843 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1146883002844 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1146883002845 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1146883002846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883002847 motif II; other site 1146883002848 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1146883002849 Isochorismatase family; Region: Isochorismatase; pfam00857 1146883002850 catalytic triad [active] 1146883002851 metal binding site [ion binding]; metal-binding site 1146883002852 conserved cis-peptide bond; other site 1146883002853 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1146883002854 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1146883002855 active site 1146883002856 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1146883002857 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1146883002858 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1146883002859 MPN+ (JAMM) motif; other site 1146883002860 Zinc-binding site [ion binding]; other site 1146883002861 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1146883002862 MoaE interaction surface [polypeptide binding]; other site 1146883002863 MoeB interaction surface [polypeptide binding]; other site 1146883002864 thiocarboxylated glycine; other site 1146883002865 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1146883002866 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1146883002867 dimer interface [polypeptide binding]; other site 1146883002868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883002869 catalytic residue [active] 1146883002870 glutamate racemase; Provisional; Region: PRK00865 1146883002871 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1146883002872 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1146883002873 nucleotide binding site [chemical binding]; other site 1146883002874 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1146883002875 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1146883002876 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1146883002877 catalytic triad [active] 1146883002878 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1146883002879 ribonuclease PH; Reviewed; Region: rph; PRK00173 1146883002880 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1146883002881 hexamer interface [polypeptide binding]; other site 1146883002882 active site 1146883002883 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1146883002884 active site 1146883002885 dimerization interface [polypeptide binding]; other site 1146883002886 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1146883002887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883002888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883002889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883002890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883002891 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1146883002892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883002893 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883002894 active site 1146883002895 catalytic tetrad [active] 1146883002896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883002897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883002898 active site 1146883002899 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883002900 CoenzymeA binding site [chemical binding]; other site 1146883002901 subunit interaction site [polypeptide binding]; other site 1146883002902 PHB binding site; other site 1146883002903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883002904 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883002905 Walker A motif; other site 1146883002906 ATP binding site [chemical binding]; other site 1146883002907 Walker B motif; other site 1146883002908 arginine finger; other site 1146883002909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883002910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883002911 NAD(P) binding site [chemical binding]; other site 1146883002912 active site 1146883002913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1146883002914 benzoate transport; Region: 2A0115; TIGR00895 1146883002915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883002916 putative substrate translocation pore; other site 1146883002917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883002918 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1146883002919 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1146883002920 active site 1146883002921 metal binding site [ion binding]; metal-binding site 1146883002922 nudix motif; other site 1146883002923 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1146883002924 classical (c) SDRs; Region: SDR_c; cd05233 1146883002925 NAD(P) binding site [chemical binding]; other site 1146883002926 active site 1146883002927 PAS fold; Region: PAS_2; pfam08446 1146883002928 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883002929 GAF domain; Region: GAF; pfam01590 1146883002930 Phytochrome region; Region: PHY; pfam00360 1146883002931 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883002932 heme binding pocket [chemical binding]; other site 1146883002933 heme ligand [chemical binding]; other site 1146883002934 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1146883002935 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883002936 Proline dehydrogenase; Region: Pro_dh; cl03282 1146883002937 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1146883002938 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1146883002939 NAD(P) binding site [chemical binding]; other site 1146883002940 catalytic residues [active] 1146883002941 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1146883002942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1146883002943 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1146883002944 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1146883002945 Cupin domain; Region: Cupin_2; pfam07883 1146883002946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883002947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883002948 DNA binding residues [nucleotide binding] 1146883002949 dimerization interface [polypeptide binding]; other site 1146883002950 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1146883002951 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1146883002952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883002953 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1146883002954 Walker A/P-loop; other site 1146883002955 ATP binding site [chemical binding]; other site 1146883002956 Q-loop/lid; other site 1146883002957 ABC transporter signature motif; other site 1146883002958 Walker B; other site 1146883002959 D-loop; other site 1146883002960 H-loop/switch region; other site 1146883002961 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883002962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883002963 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1146883002964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883002965 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883002966 Walker A/P-loop; other site 1146883002967 ATP binding site [chemical binding]; other site 1146883002968 Q-loop/lid; other site 1146883002969 ABC transporter signature motif; other site 1146883002970 Walker B; other site 1146883002971 D-loop; other site 1146883002972 H-loop/switch region; other site 1146883002973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883002974 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883002975 Walker A/P-loop; other site 1146883002976 ATP binding site [chemical binding]; other site 1146883002977 Q-loop/lid; other site 1146883002978 ABC transporter signature motif; other site 1146883002979 Walker B; other site 1146883002980 D-loop; other site 1146883002981 H-loop/switch region; other site 1146883002982 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883002983 TM-ABC transporter signature motif; other site 1146883002984 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1146883002985 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883002986 TM-ABC transporter signature motif; other site 1146883002987 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1146883002988 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883002989 integrase; Provisional; Region: int; PHA02601 1146883002990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883002991 active site 1146883002992 DNA binding site [nucleotide binding] 1146883002993 Int/Topo IB signature motif; other site 1146883002994 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1146883002995 SEC-C motif; Region: SEC-C; pfam02810 1146883002996 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883002997 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1146883002998 AAA domain; Region: AAA_30; pfam13604 1146883002999 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1146883003000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1146883003001 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1146883003002 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1146883003003 VPS10 domain; Region: VPS10; smart00602 1146883003004 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1146883003005 MoaE interaction surface [polypeptide binding]; other site 1146883003006 MoeB interaction surface [polypeptide binding]; other site 1146883003007 thiocarboxylated glycine; other site 1146883003008 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1146883003009 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1146883003010 acyl-activating enzyme (AAE) consensus motif; other site 1146883003011 putative AMP binding site [chemical binding]; other site 1146883003012 putative active site [active] 1146883003013 putative CoA binding site [chemical binding]; other site 1146883003014 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883003015 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883003016 active site 1146883003017 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1146883003018 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1146883003019 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1146883003020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883003021 substrate binding site [chemical binding]; other site 1146883003022 oxyanion hole (OAH) forming residues; other site 1146883003023 trimer interface [polypeptide binding]; other site 1146883003024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1146883003025 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1146883003026 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1146883003027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883003028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883003029 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1146883003030 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1146883003031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883003032 Ligand Binding Site [chemical binding]; other site 1146883003033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883003034 dimerization interface [polypeptide binding]; other site 1146883003035 putative DNA binding site [nucleotide binding]; other site 1146883003036 putative Zn2+ binding site [ion binding]; other site 1146883003037 Cation efflux family; Region: Cation_efflux; cl00316 1146883003038 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1146883003039 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1146883003040 homodimer interface [polypeptide binding]; other site 1146883003041 active site 1146883003042 SAM binding site [chemical binding]; other site 1146883003043 hypothetical protein; Provisional; Region: PRK07908 1146883003044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883003045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883003046 homodimer interface [polypeptide binding]; other site 1146883003047 catalytic residue [active] 1146883003048 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1146883003049 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1146883003050 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1146883003051 Walker A/P-loop; other site 1146883003052 ATP binding site [chemical binding]; other site 1146883003053 Q-loop/lid; other site 1146883003054 ABC transporter signature motif; other site 1146883003055 Walker B; other site 1146883003056 D-loop; other site 1146883003057 H-loop/switch region; other site 1146883003058 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1146883003059 cobalt transport protein CbiN; Provisional; Region: PRK02898 1146883003060 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1146883003061 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1146883003062 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1146883003063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1146883003064 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1146883003065 catalytic triad [active] 1146883003066 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1146883003067 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1146883003068 homodimer interface [polypeptide binding]; other site 1146883003069 Walker A motif; other site 1146883003070 ATP binding site [chemical binding]; other site 1146883003071 hydroxycobalamin binding site [chemical binding]; other site 1146883003072 Walker B motif; other site 1146883003073 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 1146883003074 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1146883003075 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1146883003076 metal ion-dependent adhesion site (MIDAS); other site 1146883003077 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1146883003078 active site 1146883003079 putative homodimer interface [polypeptide binding]; other site 1146883003080 SAM binding site [chemical binding]; other site 1146883003081 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1146883003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883003083 S-adenosylmethionine binding site [chemical binding]; other site 1146883003084 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1146883003085 active site 1146883003086 SAM binding site [chemical binding]; other site 1146883003087 homodimer interface [polypeptide binding]; other site 1146883003088 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1146883003089 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1146883003090 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1146883003091 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1146883003092 Divergent AAA domain; Region: AAA_4; pfam04326 1146883003093 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1146883003094 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1146883003095 active site 1146883003096 SAM binding site [chemical binding]; other site 1146883003097 homodimer interface [polypeptide binding]; other site 1146883003098 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1146883003099 active site 1146883003100 SAM binding site [chemical binding]; other site 1146883003101 homodimer interface [polypeptide binding]; other site 1146883003102 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1146883003103 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1146883003104 RibD C-terminal domain; Region: RibD_C; cl17279 1146883003105 precorrin-3B synthase; Region: CobG; TIGR02435 1146883003106 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1146883003107 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1146883003108 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1146883003109 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1146883003110 RES domain; Region: RES; smart00953 1146883003111 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1146883003112 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1146883003113 catalytic site [active] 1146883003114 putative active site [active] 1146883003115 putative substrate binding site [chemical binding]; other site 1146883003116 dimer interface [polypeptide binding]; other site 1146883003117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883003118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883003119 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1146883003120 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1146883003121 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1146883003122 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1146883003123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883003124 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1146883003125 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1146883003126 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883003127 carboxyltransferase (CT) interaction site; other site 1146883003128 biotinylation site [posttranslational modification]; other site 1146883003129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883003130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883003131 active site 1146883003132 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1146883003133 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1146883003134 intersubunit interface [polypeptide binding]; other site 1146883003135 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883003136 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1146883003137 NAD(P) binding site [chemical binding]; other site 1146883003138 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1146883003139 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1146883003140 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1146883003141 Cupin domain; Region: Cupin_2; cl17218 1146883003142 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1146883003143 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1146883003144 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883003145 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1146883003146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883003147 acyl-activating enzyme (AAE) consensus motif; other site 1146883003148 AMP binding site [chemical binding]; other site 1146883003149 active site 1146883003150 CoA binding site [chemical binding]; other site 1146883003151 hypothetical protein; Provisional; Region: PRK08296 1146883003152 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1146883003153 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1146883003154 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883003155 carboxyltransferase (CT) interaction site; other site 1146883003156 biotinylation site [posttranslational modification]; other site 1146883003157 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1146883003158 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883003159 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883003160 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1146883003161 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 1146883003162 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1146883003163 active site 1146883003164 catalytic residues [active] 1146883003165 metal binding site [ion binding]; metal-binding site 1146883003166 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1146883003167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883003168 active site 1146883003169 motif I; other site 1146883003170 motif II; other site 1146883003171 FO synthase; Reviewed; Region: fbiC; PRK09234 1146883003172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883003173 FeS/SAM binding site; other site 1146883003174 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1146883003175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883003176 FeS/SAM binding site; other site 1146883003177 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883003178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1146883003179 Walker A/P-loop; other site 1146883003180 ATP binding site [chemical binding]; other site 1146883003181 Q-loop/lid; other site 1146883003182 ABC transporter signature motif; other site 1146883003183 Walker B; other site 1146883003184 D-loop; other site 1146883003185 H-loop/switch region; other site 1146883003186 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1146883003187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883003188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883003189 DNA binding residues [nucleotide binding] 1146883003190 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1146883003191 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1146883003192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883003193 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1146883003194 PAS domain; Region: PAS_9; pfam13426 1146883003195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883003196 putative active site [active] 1146883003197 heme pocket [chemical binding]; other site 1146883003198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883003199 metal binding site [ion binding]; metal-binding site 1146883003200 active site 1146883003201 I-site; other site 1146883003202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883003203 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1146883003204 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1146883003205 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1146883003206 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1146883003207 dimerization interface [polypeptide binding]; other site 1146883003208 active site 1146883003209 L-aspartate oxidase; Provisional; Region: PRK07804 1146883003210 L-aspartate oxidase; Provisional; Region: PRK06175 1146883003211 quinolinate synthetase; Provisional; Region: PRK09375 1146883003212 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1146883003213 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1146883003214 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1146883003215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1146883003216 dimer interface [polypeptide binding]; other site 1146883003217 ssDNA binding site [nucleotide binding]; other site 1146883003218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1146883003219 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1146883003220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883003221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883003222 ABC transporter; Region: ABC_tran_2; pfam12848 1146883003223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883003224 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1146883003225 active site 1146883003226 MOSC domain; Region: MOSC; pfam03473 1146883003227 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1146883003228 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1146883003229 Walker A/P-loop; other site 1146883003230 ATP binding site [chemical binding]; other site 1146883003231 Q-loop/lid; other site 1146883003232 ABC transporter signature motif; other site 1146883003233 Walker B; other site 1146883003234 D-loop; other site 1146883003235 H-loop/switch region; other site 1146883003236 BioY family; Region: BioY; pfam02632 1146883003237 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1146883003238 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1146883003239 active site 1146883003240 catalytic site [active] 1146883003241 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1146883003242 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1146883003243 apolar tunnel; other site 1146883003244 heme binding site [chemical binding]; other site 1146883003245 dimerization interface [polypeptide binding]; other site 1146883003246 H+ Antiporter protein; Region: 2A0121; TIGR00900 1146883003247 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1146883003248 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1146883003249 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1146883003250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883003251 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1146883003252 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883003253 active site 1146883003254 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1146883003255 active site 1146883003256 catalytic site [active] 1146883003257 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1146883003258 Amidase; Region: Amidase; cl11426 1146883003259 Repair protein; Region: Repair_PSII; pfam04536 1146883003260 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1146883003261 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1146883003262 Zn binding site [ion binding]; other site 1146883003263 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1146883003264 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1146883003265 short chain dehydrogenase; Provisional; Region: PRK08251 1146883003266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883003267 NAD(P) binding site [chemical binding]; other site 1146883003268 active site 1146883003269 Protein of unknown function (DUF429); Region: DUF429; pfam04250 1146883003270 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1146883003271 hypothetical protein; Provisional; Region: PRK01346 1146883003272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883003273 Coenzyme A binding pocket [chemical binding]; other site 1146883003274 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1146883003275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883003276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883003277 DNA binding residues [nucleotide binding] 1146883003278 SnoaL-like domain; Region: SnoaL_2; pfam12680 1146883003279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883003280 putative substrate translocation pore; other site 1146883003281 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1146883003282 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1146883003283 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1146883003284 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1146883003285 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1146883003286 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1146883003287 ligand binding site [chemical binding]; other site 1146883003288 flexible hinge region; other site 1146883003289 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1146883003290 non-specific DNA interactions [nucleotide binding]; other site 1146883003291 DNA binding site [nucleotide binding] 1146883003292 sequence specific DNA binding site [nucleotide binding]; other site 1146883003293 putative cAMP binding site [chemical binding]; other site 1146883003294 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1146883003295 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1146883003296 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1146883003297 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1146883003298 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883003299 catalytic loop [active] 1146883003300 iron binding site [ion binding]; other site 1146883003301 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1146883003302 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1146883003303 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1146883003304 Hemerythrin-like domain; Region: Hr-like; cd12108 1146883003305 Fe binding site [ion binding]; other site 1146883003306 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1146883003307 Predicted ATPase [General function prediction only]; Region: COG3903 1146883003308 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1146883003309 potential frameshift: common BLAST hit: gi|284990220|ref|YP_003408774.1| alcohol dehydrogenase zinc-binding domain-containing protein 1146883003310 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883003311 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883003312 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883003313 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1146883003314 putative NAD(P) binding site [chemical binding]; other site 1146883003315 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1146883003316 active site 1146883003317 Gp37 protein; Region: Gp37; pfam09646 1146883003318 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1146883003319 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883003320 metal-binding site [ion binding] 1146883003321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883003322 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1146883003323 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883003324 metal-binding site [ion binding] 1146883003325 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1146883003326 AAA ATPase domain; Region: AAA_16; pfam13191 1146883003327 Predicted ATPase [General function prediction only]; Region: COG3903 1146883003328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883003329 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1146883003330 putative substrate translocation pore; other site 1146883003331 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1146883003332 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1146883003333 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1146883003334 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1146883003335 PemK-like protein; Region: PemK; pfam02452 1146883003336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883003337 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1146883003338 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1146883003339 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883003340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883003341 Walker A/P-loop; other site 1146883003342 ATP binding site [chemical binding]; other site 1146883003343 Q-loop/lid; other site 1146883003344 ABC transporter signature motif; other site 1146883003345 Walker B; other site 1146883003346 D-loop; other site 1146883003347 H-loop/switch region; other site 1146883003348 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1146883003349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883003350 Histidine kinase; Region: HisKA_3; pfam07730 1146883003351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883003352 ATP binding site [chemical binding]; other site 1146883003353 Mg2+ binding site [ion binding]; other site 1146883003354 G-X-G motif; other site 1146883003355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883003356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883003357 active site 1146883003358 phosphorylation site [posttranslational modification] 1146883003359 intermolecular recognition site; other site 1146883003360 dimerization interface [polypeptide binding]; other site 1146883003361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883003362 DNA binding residues [nucleotide binding] 1146883003363 dimerization interface [polypeptide binding]; other site 1146883003364 YCII-related domain; Region: YCII; cl00999 1146883003365 YCII-related domain; Region: YCII; cl00999 1146883003366 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883003367 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1146883003368 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1146883003369 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1146883003370 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1146883003371 NAD(P) binding site [chemical binding]; other site 1146883003372 catalytic residues [active] 1146883003373 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1146883003374 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1146883003375 active site 1146883003376 NAD binding site [chemical binding]; other site 1146883003377 metal binding site [ion binding]; metal-binding site 1146883003378 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1146883003379 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1146883003380 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1146883003381 dimerization interface [polypeptide binding]; other site 1146883003382 active site 1146883003383 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1146883003384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1146883003385 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1146883003386 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1146883003387 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1146883003388 ligand binding site [chemical binding]; other site 1146883003389 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1146883003390 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1146883003391 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1146883003392 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1146883003393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883003394 Walker A/P-loop; other site 1146883003395 ATP binding site [chemical binding]; other site 1146883003396 Q-loop/lid; other site 1146883003397 ABC transporter signature motif; other site 1146883003398 Walker B; other site 1146883003399 D-loop; other site 1146883003400 H-loop/switch region; other site 1146883003401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1146883003402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883003403 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883003404 TM-ABC transporter signature motif; other site 1146883003405 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1146883003406 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883003407 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1146883003408 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1146883003409 metal binding site [ion binding]; metal-binding site 1146883003410 substrate binding pocket [chemical binding]; other site 1146883003411 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883003412 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1146883003413 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1146883003414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1146883003415 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1146883003416 substrate binding pocket [chemical binding]; other site 1146883003417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883003418 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883003419 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1146883003420 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883003421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883003422 DNA-binding site [nucleotide binding]; DNA binding site 1146883003423 FCD domain; Region: FCD; pfam07729 1146883003424 SnoaL-like domain; Region: SnoaL_4; pfam13577 1146883003425 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883003426 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1146883003427 catalytic site [active] 1146883003428 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1146883003429 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1146883003430 active site 1146883003431 catalytic triad [active] 1146883003432 dimer interface [polypeptide binding]; other site 1146883003433 MULE transposase domain; Region: MULE; pfam10551 1146883003434 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883003435 DNA polymerase II large subunit; Provisional; Region: PRK14714 1146883003436 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1146883003437 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1146883003438 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883003439 active site 1146883003440 DNA binding site [nucleotide binding] 1146883003441 Int/Topo IB signature motif; other site 1146883003442 AAA domain; Region: AAA_17; pfam13207 1146883003443 AAA domain; Region: AAA_18; pfam13238 1146883003444 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883003445 putative catalytic site [active] 1146883003446 putative metal binding site [ion binding]; other site 1146883003447 putative phosphate binding site [ion binding]; other site 1146883003448 MULE transposase domain; Region: MULE; pfam10551 1146883003449 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883003450 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1146883003451 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1146883003452 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1146883003453 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1146883003454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883003455 active site 1146883003456 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1146883003457 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1146883003458 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1146883003459 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1146883003460 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1146883003461 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1146883003462 dimerization interface [polypeptide binding]; other site 1146883003463 active site 1146883003464 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1146883003465 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883003466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883003467 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1146883003468 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883003469 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883003470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883003471 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1146883003472 dimerization interface [polypeptide binding]; other site 1146883003473 substrate binding pocket [chemical binding]; other site 1146883003474 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883003475 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1146883003476 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883003477 Muconolactone delta-isomerase; Region: MIase; cl01992 1146883003478 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1146883003479 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1146883003480 tetramer interface [polypeptide binding]; other site 1146883003481 TPP-binding site [chemical binding]; other site 1146883003482 heterodimer interface [polypeptide binding]; other site 1146883003483 phosphorylation loop region [posttranslational modification] 1146883003484 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1146883003485 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1146883003486 alpha subunit interface [polypeptide binding]; other site 1146883003487 TPP binding site [chemical binding]; other site 1146883003488 heterodimer interface [polypeptide binding]; other site 1146883003489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1146883003490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883003491 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883003492 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1146883003493 catalytic loop [active] 1146883003494 iron binding site [ion binding]; other site 1146883003495 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1146883003496 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1146883003497 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1146883003498 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1146883003499 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1146883003500 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1146883003501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883003502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883003503 ATP binding site [chemical binding]; other site 1146883003504 Mg2+ binding site [ion binding]; other site 1146883003505 G-X-G motif; other site 1146883003506 hypothetical protein; Provisional; Region: PRK07236 1146883003507 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1146883003508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883003509 GAF domain; Region: GAF; pfam01590 1146883003510 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883003511 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1146883003512 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1146883003513 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1146883003514 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883003515 catalytic loop [active] 1146883003516 iron binding site [ion binding]; other site 1146883003517 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1146883003518 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1146883003519 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1146883003520 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1146883003521 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1146883003522 putative hydrophobic ligand binding site [chemical binding]; other site 1146883003523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883003524 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883003525 Walker A motif; other site 1146883003526 ATP binding site [chemical binding]; other site 1146883003527 Walker B motif; other site 1146883003528 arginine finger; other site 1146883003529 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1146883003530 metal ion-dependent adhesion site (MIDAS); other site 1146883003531 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1146883003532 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1146883003533 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1146883003534 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1146883003535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883003536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883003537 DNA binding residues [nucleotide binding] 1146883003538 dimerization interface [polypeptide binding]; other site 1146883003539 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883003540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883003541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883003542 active site 1146883003543 Int/Topo IB signature motif; other site 1146883003544 DNA binding site [nucleotide binding] 1146883003545 Helix-turn-helix domain; Region: HTH_17; cl17695 1146883003546 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883003547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883003548 non-specific DNA binding site [nucleotide binding]; other site 1146883003549 salt bridge; other site 1146883003550 sequence-specific DNA binding site [nucleotide binding]; other site 1146883003551 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1146883003552 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1146883003553 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883003554 Walker A motif; other site 1146883003555 ATP binding site [chemical binding]; other site 1146883003556 Walker B motif; other site 1146883003557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883003558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883003559 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1146883003560 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1146883003561 AAA-like domain; Region: AAA_10; pfam12846 1146883003562 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883003563 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883003564 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1146883003565 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1146883003566 putative transposase OrfB; Reviewed; Region: PHA02517 1146883003567 Integrase core domain; Region: rve; pfam00665 1146883003568 Integrase core domain; Region: rve_3; pfam13683 1146883003569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883003570 nucleotide binding region [chemical binding]; other site 1146883003571 ATP-binding site [chemical binding]; other site 1146883003572 MULE transposase domain; Region: MULE; pfam10551 1146883003573 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883003574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883003575 ATP binding site [chemical binding]; other site 1146883003576 putative Mg++ binding site [ion binding]; other site 1146883003577 TrwC relaxase; Region: TrwC; pfam08751 1146883003578 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883003579 AAA domain; Region: AAA_30; pfam13604 1146883003580 Family description; Region: UvrD_C_2; pfam13538 1146883003581 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1146883003582 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1146883003583 active site 1146883003584 metal binding site [ion binding]; metal-binding site 1146883003585 interdomain interaction site; other site 1146883003586 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1146883003587 Integrase core domain; Region: rve; pfam00665 1146883003588 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1146883003589 AAA domain; Region: AAA_22; pfam13401 1146883003590 Bacterial TniB protein; Region: TniB; pfam05621 1146883003591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883003592 S-adenosylmethionine binding site [chemical binding]; other site 1146883003593 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1146883003594 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1146883003595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883003596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883003597 ATP binding site [chemical binding]; other site 1146883003598 G-X-G motif; other site 1146883003599 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1146883003600 Predicted helicase [General function prediction only]; Region: COG4889 1146883003601 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1146883003602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883003603 ATP binding site [chemical binding]; other site 1146883003604 putative Mg++ binding site [ion binding]; other site 1146883003605 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1146883003606 nucleotide binding region [chemical binding]; other site 1146883003607 ATP-binding site [chemical binding]; other site 1146883003608 Histidine kinase; Region: HisKA_3; pfam07730 1146883003609 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1146883003610 Amidase; Region: Amidase; cl11426 1146883003611 trigger factor; Provisional; Region: tig; PRK01490 1146883003612 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1146883003613 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1146883003614 Clp protease; Region: CLP_protease; pfam00574 1146883003615 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1146883003616 oligomer interface [polypeptide binding]; other site 1146883003617 active site residues [active] 1146883003618 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1146883003619 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1146883003620 oligomer interface [polypeptide binding]; other site 1146883003621 active site residues [active] 1146883003622 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1146883003623 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1146883003624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883003625 Walker A motif; other site 1146883003626 ATP binding site [chemical binding]; other site 1146883003627 Walker B motif; other site 1146883003628 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1146883003629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883003630 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1146883003631 active site 1146883003632 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883003633 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883003634 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1146883003635 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883003636 active site 1146883003637 HIGH motif; other site 1146883003638 nucleotide binding site [chemical binding]; other site 1146883003639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883003640 active site 1146883003641 KMSKS motif; other site 1146883003642 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1146883003643 tRNA binding surface [nucleotide binding]; other site 1146883003644 anticodon binding site; other site 1146883003645 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1146883003646 hypothetical protein; Provisional; Region: PRK11770 1146883003647 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1146883003648 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1146883003649 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1146883003650 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1146883003651 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1146883003652 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1146883003653 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1146883003654 active site 1146883003655 multimer interface [polypeptide binding]; other site 1146883003656 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883003657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883003658 Walker A/P-loop; other site 1146883003659 ATP binding site [chemical binding]; other site 1146883003660 Q-loop/lid; other site 1146883003661 ABC transporter signature motif; other site 1146883003662 Walker B; other site 1146883003663 D-loop; other site 1146883003664 H-loop/switch region; other site 1146883003665 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1146883003666 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883003667 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883003668 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1146883003669 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1146883003670 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1146883003671 B12 binding site [chemical binding]; other site 1146883003672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883003673 FeS/SAM binding site; other site 1146883003674 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1146883003675 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1146883003676 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1146883003677 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1146883003678 homodimer interface [polypeptide binding]; other site 1146883003679 oligonucleotide binding site [chemical binding]; other site 1146883003680 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1146883003681 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1146883003682 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1146883003683 GTP1/OBG; Region: GTP1_OBG; pfam01018 1146883003684 Obg GTPase; Region: Obg; cd01898 1146883003685 G1 box; other site 1146883003686 GTP/Mg2+ binding site [chemical binding]; other site 1146883003687 Switch I region; other site 1146883003688 G2 box; other site 1146883003689 G3 box; other site 1146883003690 Switch II region; other site 1146883003691 G4 box; other site 1146883003692 G5 box; other site 1146883003693 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1146883003694 gamma-glutamyl kinase; Provisional; Region: PRK05429 1146883003695 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1146883003696 nucleotide binding site [chemical binding]; other site 1146883003697 homotetrameric interface [polypeptide binding]; other site 1146883003698 putative phosphate binding site [ion binding]; other site 1146883003699 putative allosteric binding site; other site 1146883003700 PUA domain; Region: PUA; pfam01472 1146883003701 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1146883003702 active site 1146883003703 catalytic residues [active] 1146883003704 metal binding site [ion binding]; metal-binding site 1146883003705 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1146883003706 metal binding site 2 [ion binding]; metal-binding site 1146883003707 putative DNA binding helix; other site 1146883003708 metal binding site 1 [ion binding]; metal-binding site 1146883003709 dimer interface [polypeptide binding]; other site 1146883003710 structural Zn2+ binding site [ion binding]; other site 1146883003711 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1146883003712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1146883003713 ABC-ATPase subunit interface; other site 1146883003714 dimer interface [polypeptide binding]; other site 1146883003715 putative PBP binding regions; other site 1146883003716 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1146883003717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883003718 Walker A/P-loop; other site 1146883003719 ATP binding site [chemical binding]; other site 1146883003720 Q-loop/lid; other site 1146883003721 ABC transporter signature motif; other site 1146883003722 Walker B; other site 1146883003723 D-loop; other site 1146883003724 H-loop/switch region; other site 1146883003725 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1146883003726 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1146883003727 intersubunit interface [polypeptide binding]; other site 1146883003728 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1146883003729 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1146883003730 putative catalytic cysteine [active] 1146883003731 MoxR-like ATPases [General function prediction only]; Region: COG0714 1146883003732 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1146883003733 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1146883003734 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 1146883003735 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1146883003736 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1146883003737 active site 1146883003738 (T/H)XGH motif; other site 1146883003739 Oligomerisation domain; Region: Oligomerisation; cl00519 1146883003740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883003741 catalytic core [active] 1146883003742 EDD domain protein, DegV family; Region: DegV; TIGR00762 1146883003743 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1146883003744 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1146883003745 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1146883003746 Competence protein; Region: Competence; pfam03772 1146883003747 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1146883003748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883003749 hypothetical protein; Reviewed; Region: PRK07914 1146883003750 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1146883003751 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1146883003752 GTP-binding protein LepA; Provisional; Region: PRK05433 1146883003753 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1146883003754 G1 box; other site 1146883003755 putative GEF interaction site [polypeptide binding]; other site 1146883003756 GTP/Mg2+ binding site [chemical binding]; other site 1146883003757 Switch I region; other site 1146883003758 G2 box; other site 1146883003759 G3 box; other site 1146883003760 Switch II region; other site 1146883003761 G4 box; other site 1146883003762 G5 box; other site 1146883003763 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1146883003764 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1146883003765 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1146883003766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1146883003767 MOSC domain; Region: MOSC; pfam03473 1146883003768 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1146883003769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883003770 Clp amino terminal domain; Region: Clp_N; pfam02861 1146883003771 Homeodomain-like domain; Region: HTH_23; cl17451 1146883003772 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1146883003773 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883003774 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883003775 NAD(P) binding site [chemical binding]; other site 1146883003776 selenium donor protein; Region: selD; TIGR00476 1146883003777 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1146883003778 dimerization interface [polypeptide binding]; other site 1146883003779 putative ATP binding site [chemical binding]; other site 1146883003780 selenocysteine synthase; Provisional; Region: PRK04311 1146883003781 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883003782 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883003783 catalytic residue [active] 1146883003784 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1146883003785 G1 box; other site 1146883003786 GTP/Mg2+ binding site [chemical binding]; other site 1146883003787 G2 box; other site 1146883003788 Switch I region; other site 1146883003789 G3 box; other site 1146883003790 Switch II region; other site 1146883003791 G4 box; other site 1146883003792 G5 box; other site 1146883003793 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1146883003794 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1146883003795 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1146883003796 enoyl-CoA hydratase; Provisional; Region: PRK07827 1146883003797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883003798 substrate binding site [chemical binding]; other site 1146883003799 oxyanion hole (OAH) forming residues; other site 1146883003800 trimer interface [polypeptide binding]; other site 1146883003801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1146883003802 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1146883003803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883003804 FeS/SAM binding site; other site 1146883003805 HemN C-terminal domain; Region: HemN_C; pfam06969 1146883003806 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1146883003807 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1146883003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883003809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883003810 Histidine kinase; Region: HisKA_3; pfam07730 1146883003811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883003812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883003813 active site 1146883003814 phosphorylation site [posttranslational modification] 1146883003815 intermolecular recognition site; other site 1146883003816 dimerization interface [polypeptide binding]; other site 1146883003817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1146883003818 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1146883003819 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1146883003820 HTH domain; Region: HTH_11; pfam08279 1146883003821 chaperone protein DnaJ; Provisional; Region: PRK14278 1146883003822 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1146883003823 HSP70 interaction site [polypeptide binding]; other site 1146883003824 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1146883003825 Zn binding sites [ion binding]; other site 1146883003826 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1146883003827 dimer interface [polypeptide binding]; other site 1146883003828 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1146883003829 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1146883003830 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1146883003831 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1146883003832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883003833 Walker A/P-loop; other site 1146883003834 ATP binding site [chemical binding]; other site 1146883003835 Q-loop/lid; other site 1146883003836 ABC transporter signature motif; other site 1146883003837 Walker B; other site 1146883003838 D-loop; other site 1146883003839 H-loop/switch region; other site 1146883003840 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1146883003841 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1146883003842 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883003843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883003844 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883003845 TM-ABC transporter signature motif; other site 1146883003846 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1146883003847 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883003848 TM-ABC transporter signature motif; other site 1146883003849 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883003850 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883003851 Walker A/P-loop; other site 1146883003852 ATP binding site [chemical binding]; other site 1146883003853 Q-loop/lid; other site 1146883003854 ABC transporter signature motif; other site 1146883003855 Walker B; other site 1146883003856 D-loop; other site 1146883003857 H-loop/switch region; other site 1146883003858 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883003859 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883003860 Walker A/P-loop; other site 1146883003861 ATP binding site [chemical binding]; other site 1146883003862 Q-loop/lid; other site 1146883003863 ABC transporter signature motif; other site 1146883003864 Walker B; other site 1146883003865 D-loop; other site 1146883003866 H-loop/switch region; other site 1146883003867 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1146883003868 nucleotide binding site/active site [active] 1146883003869 HIT family signature motif; other site 1146883003870 catalytic residue [active] 1146883003871 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1146883003872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883003873 substrate binding site [chemical binding]; other site 1146883003874 oxyanion hole (OAH) forming residues; other site 1146883003875 trimer interface [polypeptide binding]; other site 1146883003876 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1146883003877 PhoH-like protein; Region: PhoH; pfam02562 1146883003878 metal-binding heat shock protein; Provisional; Region: PRK00016 1146883003879 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1146883003880 Domain of unknown function DUF21; Region: DUF21; pfam01595 1146883003881 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1146883003882 Transporter associated domain; Region: CorC_HlyC; smart01091 1146883003883 GTPase Era; Reviewed; Region: era; PRK00089 1146883003884 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1146883003885 G1 box; other site 1146883003886 GTP/Mg2+ binding site [chemical binding]; other site 1146883003887 Switch I region; other site 1146883003888 G2 box; other site 1146883003889 Switch II region; other site 1146883003890 G3 box; other site 1146883003891 G4 box; other site 1146883003892 KH domain; Region: KH_2; pfam07650 1146883003893 Recombination protein O N terminal; Region: RecO_N; pfam11967 1146883003894 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1146883003895 Recombination protein O C terminal; Region: RecO_C; pfam02565 1146883003896 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1146883003897 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1146883003898 catalytic residue [active] 1146883003899 putative FPP diphosphate binding site; other site 1146883003900 putative FPP binding hydrophobic cleft; other site 1146883003901 dimer interface [polypeptide binding]; other site 1146883003902 putative IPP diphosphate binding site; other site 1146883003903 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1146883003904 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1146883003905 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1146883003906 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1146883003907 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1146883003908 motif 1; other site 1146883003909 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1146883003910 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1146883003911 active site 1146883003912 motif 2; other site 1146883003913 motif 3; other site 1146883003914 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1146883003915 anticodon binding site; other site 1146883003916 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1146883003917 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1146883003918 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1146883003919 FMN binding site [chemical binding]; other site 1146883003920 active site 1146883003921 catalytic residues [active] 1146883003922 substrate binding site [chemical binding]; other site 1146883003923 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1146883003924 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1146883003925 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1146883003926 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1146883003927 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1146883003928 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1146883003929 putative active site [active] 1146883003930 DNA primase; Validated; Region: dnaG; PRK05667 1146883003931 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1146883003932 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1146883003933 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1146883003934 active site 1146883003935 metal binding site [ion binding]; metal-binding site 1146883003936 interdomain interaction site; other site 1146883003937 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1146883003938 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1146883003939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883003940 MULE transposase domain; Region: MULE; pfam10551 1146883003941 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883003942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883003943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883003944 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1146883003945 putative active site [active] 1146883003946 catalytic site [active] 1146883003947 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1146883003948 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883003949 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883003950 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1146883003951 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1146883003952 FAD binding pocket [chemical binding]; other site 1146883003953 FAD binding motif [chemical binding]; other site 1146883003954 phosphate binding motif [ion binding]; other site 1146883003955 beta-alpha-beta structure motif; other site 1146883003956 NAD binding pocket [chemical binding]; other site 1146883003957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883003958 catalytic loop [active] 1146883003959 iron binding site [ion binding]; other site 1146883003960 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1146883003961 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883003962 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883003963 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1146883003964 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1146883003965 [2Fe-2S] cluster binding site [ion binding]; other site 1146883003966 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1146883003967 putative alpha subunit interface [polypeptide binding]; other site 1146883003968 putative active site [active] 1146883003969 putative substrate binding site [chemical binding]; other site 1146883003970 Fe binding site [ion binding]; other site 1146883003971 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1146883003972 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1146883003973 active site 1146883003974 BCCT family transporter; Region: BCCT; pfam02028 1146883003975 Winged helix-turn helix; Region: HTH_29; pfam13551 1146883003976 Helix-turn-helix domain; Region: HTH_28; pfam13518 1146883003977 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883003978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883003979 DNA-binding site [nucleotide binding]; DNA binding site 1146883003980 FCD domain; Region: FCD; pfam07729 1146883003981 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1146883003982 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1146883003983 putative active site [active] 1146883003984 putative FMN binding site [chemical binding]; other site 1146883003985 putative substrate binding site [chemical binding]; other site 1146883003986 putative catalytic residue [active] 1146883003987 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1146883003988 putative homotetramer interface [polypeptide binding]; other site 1146883003989 putative homodimer interface [polypeptide binding]; other site 1146883003990 putative allosteric switch controlling residues; other site 1146883003991 putative metal binding site [ion binding]; other site 1146883003992 putative homodimer-homodimer interface [polypeptide binding]; other site 1146883003993 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1146883003994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1146883003995 active site residue [active] 1146883003996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883003997 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1146883003998 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1146883003999 CGNR zinc finger; Region: zf-CGNR; pfam11706 1146883004000 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1146883004001 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883004002 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1146883004003 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1146883004004 putative active site [active] 1146883004005 putative CoA binding site [chemical binding]; other site 1146883004006 nudix motif; other site 1146883004007 metal binding site [ion binding]; metal-binding site 1146883004008 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1146883004009 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883004010 metal-binding site [ion binding] 1146883004011 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883004012 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1146883004013 putative homodimer interface [polypeptide binding]; other site 1146883004014 putative homotetramer interface [polypeptide binding]; other site 1146883004015 putative allosteric switch controlling residues; other site 1146883004016 putative metal binding site [ion binding]; other site 1146883004017 putative homodimer-homodimer interface [polypeptide binding]; other site 1146883004018 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883004019 metal-binding site [ion binding] 1146883004020 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1146883004021 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1146883004022 MULE transposase domain; Region: MULE; pfam10551 1146883004023 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1146883004024 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1146883004025 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1146883004026 catalytic residues [active] 1146883004027 UTRA domain; Region: UTRA; pfam07702 1146883004028 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883004029 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883004030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883004031 catalytic residue [active] 1146883004032 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883004033 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883004034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883004035 catalytic residue [active] 1146883004036 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 1146883004037 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1146883004038 metal binding site [ion binding]; metal-binding site 1146883004039 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1146883004040 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1146883004041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883004042 catalytic residue [active] 1146883004043 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1146883004044 homotrimer interaction site [polypeptide binding]; other site 1146883004045 putative active site [active] 1146883004046 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883004047 Ligand Binding Site [chemical binding]; other site 1146883004048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1146883004049 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1146883004050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1146883004051 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1146883004052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883004053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1146883004054 dimerization interface [polypeptide binding]; other site 1146883004055 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1146883004056 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1146883004057 putative active site [active] 1146883004058 catalytic residue [active] 1146883004059 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1146883004060 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1146883004061 active site 1146883004062 tetramer interface [polypeptide binding]; other site 1146883004063 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1146883004064 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1146883004065 active site pocket [active] 1146883004066 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1146883004067 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1146883004068 dimer interface [polypeptide binding]; other site 1146883004069 NADP binding site [chemical binding]; other site 1146883004070 catalytic residues [active] 1146883004071 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883004072 Membrane transport protein; Region: Mem_trans; cl09117 1146883004073 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1146883004074 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1146883004075 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883004076 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883004077 potential frameshift: common BLAST hit: gi|284990740|ref|YP_003409294.1| peptidase S8 and S53 subtilisin kexin sedolisin 1146883004078 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1146883004079 catalytic residues [active] 1146883004080 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1146883004081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883004082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1146883004083 dimerization interface [polypeptide binding]; other site 1146883004084 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1146883004085 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1146883004086 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1146883004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883004088 dimer interface [polypeptide binding]; other site 1146883004089 conserved gate region; other site 1146883004090 putative PBP binding loops; other site 1146883004091 ABC-ATPase subunit interface; other site 1146883004092 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1146883004093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883004094 dimer interface [polypeptide binding]; other site 1146883004095 conserved gate region; other site 1146883004096 putative PBP binding loops; other site 1146883004097 ABC-ATPase subunit interface; other site 1146883004098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883004099 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1146883004100 Walker A/P-loop; other site 1146883004101 ATP binding site [chemical binding]; other site 1146883004102 Q-loop/lid; other site 1146883004103 ABC transporter signature motif; other site 1146883004104 Walker B; other site 1146883004105 D-loop; other site 1146883004106 H-loop/switch region; other site 1146883004107 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1146883004108 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1146883004109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883004110 Walker A/P-loop; other site 1146883004111 ATP binding site [chemical binding]; other site 1146883004112 Q-loop/lid; other site 1146883004113 ABC transporter signature motif; other site 1146883004114 Walker B; other site 1146883004115 D-loop; other site 1146883004116 H-loop/switch region; other site 1146883004117 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1146883004118 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1146883004119 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1146883004120 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1146883004121 metal binding site [ion binding]; metal-binding site 1146883004122 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9772162; Product type e : enzyme 1146883004123 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 1146883004124 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9772162; Product type e : enzyme 1146883004125 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1146883004126 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1146883004127 putative ligand binding site [chemical binding]; other site 1146883004128 NAD binding site [chemical binding]; other site 1146883004129 catalytic site [active] 1146883004130 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1146883004131 succinic semialdehyde dehydrogenase; Region: PLN02278 1146883004132 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1146883004133 tetramerization interface [polypeptide binding]; other site 1146883004134 NAD(P) binding site [chemical binding]; other site 1146883004135 catalytic residues [active] 1146883004136 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1146883004137 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883004138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883004139 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1146883004140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883004141 putative active site [active] 1146883004142 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883004143 GAF domain; Region: GAF; pfam01590 1146883004144 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883004145 ANTAR domain; Region: ANTAR; pfam03861 1146883004146 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1146883004147 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883004148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883004149 ATP binding site [chemical binding]; other site 1146883004150 Mg2+ binding site [ion binding]; other site 1146883004151 G-X-G motif; other site 1146883004152 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 1146883004153 TIGR02588 family protein; Region: TIGR02588 1146883004154 GAF domain; Region: GAF; cl17456 1146883004155 GAF domain; Region: GAF_2; pfam13185 1146883004156 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1146883004157 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1146883004158 active site 1146883004159 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883004160 H+ Antiporter protein; Region: 2A0121; TIGR00900 1146883004161 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1146883004162 Part of AAA domain; Region: AAA_19; pfam13245 1146883004163 Family description; Region: UvrD_C_2; pfam13538 1146883004164 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1146883004165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1146883004166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1146883004167 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883004168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1146883004169 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1146883004170 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1146883004171 substrate binding pocket [chemical binding]; other site 1146883004172 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1146883004173 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883004174 Patatin-like phospholipase; Region: Patatin; pfam01734 1146883004175 cardiolipin synthase 2; Provisional; Region: PRK11263 1146883004176 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1146883004177 putative active site [active] 1146883004178 catalytic site [active] 1146883004179 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1146883004180 putative active site [active] 1146883004181 catalytic site [active] 1146883004182 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1146883004183 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1146883004184 Moco binding site; other site 1146883004185 metal coordination site [ion binding]; other site 1146883004186 dimerization interface [polypeptide binding]; other site 1146883004187 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883004188 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883004189 TAP-like protein; Region: Abhydrolase_4; pfam08386 1146883004190 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1146883004191 active site 1146883004192 metal binding site [ion binding]; metal-binding site 1146883004193 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883004194 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1146883004195 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1146883004196 active site 1146883004197 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1146883004198 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1146883004199 active site 1146883004200 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1146883004201 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1146883004202 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1146883004203 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1146883004204 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883004205 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1146883004206 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1146883004207 putative DNA binding site [nucleotide binding]; other site 1146883004208 putative homodimer interface [polypeptide binding]; other site 1146883004209 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1146883004210 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1146883004211 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1146883004212 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1146883004213 putative FMN binding site [chemical binding]; other site 1146883004214 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 1146883004215 active site pocket [active] 1146883004216 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1146883004217 homotrimer interface [polypeptide binding]; other site 1146883004218 Walker A motif; other site 1146883004219 GTP binding site [chemical binding]; other site 1146883004220 Walker B motif; other site 1146883004221 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1146883004222 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883004223 acyl-coenzyme A oxidase; Region: PLN02526 1146883004224 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883004225 active site 1146883004226 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1146883004227 TrkA-N domain; Region: TrkA_N; pfam02254 1146883004228 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1146883004229 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1146883004230 acyl-activating enzyme (AAE) consensus motif; other site 1146883004231 putative AMP binding site [chemical binding]; other site 1146883004232 putative active site [active] 1146883004233 putative CoA binding site [chemical binding]; other site 1146883004234 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1146883004235 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1146883004236 active site 1146883004237 NAD binding site [chemical binding]; other site 1146883004238 metal binding site [ion binding]; metal-binding site 1146883004239 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883004240 CoenzymeA binding site [chemical binding]; other site 1146883004241 subunit interaction site [polypeptide binding]; other site 1146883004242 PHB binding site; other site 1146883004243 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883004244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883004245 non-specific DNA binding site [nucleotide binding]; other site 1146883004246 salt bridge; other site 1146883004247 sequence-specific DNA binding site [nucleotide binding]; other site 1146883004248 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883004249 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1146883004250 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883004251 active site 1146883004252 catalytic residues [active] 1146883004253 DNA binding site [nucleotide binding] 1146883004254 Int/Topo IB signature motif; other site 1146883004255 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883004256 active site 1146883004257 catalytic residues [active] 1146883004258 DNA binding site [nucleotide binding] 1146883004259 Int/Topo IB signature motif; other site 1146883004260 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883004261 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1146883004262 DXD motif; other site 1146883004263 HEAT repeats; Region: HEAT_2; pfam13646 1146883004264 Hpt domain; Region: Hpt; pfam01627 1146883004265 putative binding surface; other site 1146883004266 active site 1146883004267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004268 active site 1146883004269 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1146883004270 phosphorylation site [posttranslational modification] 1146883004271 intermolecular recognition site; other site 1146883004272 dimerization interface [polypeptide binding]; other site 1146883004273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004274 active site 1146883004275 phosphorylation site [posttranslational modification] 1146883004276 intermolecular recognition site; other site 1146883004277 dimerization interface [polypeptide binding]; other site 1146883004278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883004279 metal binding site [ion binding]; metal-binding site 1146883004280 active site 1146883004281 I-site; other site 1146883004282 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004284 active site 1146883004285 phosphorylation site [posttranslational modification] 1146883004286 intermolecular recognition site; other site 1146883004287 dimerization interface [polypeptide binding]; other site 1146883004288 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883004289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004290 active site 1146883004291 phosphorylation site [posttranslational modification] 1146883004292 intermolecular recognition site; other site 1146883004293 dimerization interface [polypeptide binding]; other site 1146883004294 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1146883004295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883004296 putative active site [active] 1146883004297 heme pocket [chemical binding]; other site 1146883004298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883004299 dimer interface [polypeptide binding]; other site 1146883004300 phosphorylation site [posttranslational modification] 1146883004301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883004302 ATP binding site [chemical binding]; other site 1146883004303 Mg2+ binding site [ion binding]; other site 1146883004304 G-X-G motif; other site 1146883004305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004306 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883004307 active site 1146883004308 phosphorylation site [posttranslational modification] 1146883004309 intermolecular recognition site; other site 1146883004310 dimerization interface [polypeptide binding]; other site 1146883004311 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883004312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004313 active site 1146883004314 phosphorylation site [posttranslational modification] 1146883004315 intermolecular recognition site; other site 1146883004316 dimerization interface [polypeptide binding]; other site 1146883004317 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883004318 GAF domain; Region: GAF; pfam01590 1146883004319 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883004320 PAS domain S-box; Region: sensory_box; TIGR00229 1146883004321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883004322 putative active site [active] 1146883004323 heme pocket [chemical binding]; other site 1146883004324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883004325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883004326 metal binding site [ion binding]; metal-binding site 1146883004327 active site 1146883004328 I-site; other site 1146883004329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1146883004330 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1146883004331 PAS domain S-box; Region: sensory_box; TIGR00229 1146883004332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883004333 putative active site [active] 1146883004334 heme pocket [chemical binding]; other site 1146883004335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883004336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883004337 metal binding site [ion binding]; metal-binding site 1146883004338 active site 1146883004339 I-site; other site 1146883004340 potential frameshift: common BLAST hit: gi|284993332|ref|YP_003411887.1| putative PAS/PAC sensor protein 1146883004341 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1146883004342 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1146883004343 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883004344 AAA domain; Region: AAA_30; pfam13604 1146883004345 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1146883004346 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1146883004347 Int/Topo IB signature motif; other site 1146883004348 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1146883004349 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1146883004350 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883004351 Walker A motif; other site 1146883004352 ATP binding site [chemical binding]; other site 1146883004353 Walker B motif; other site 1146883004354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883004355 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1146883004356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883004357 non-specific DNA binding site [nucleotide binding]; other site 1146883004358 salt bridge; other site 1146883004359 sequence-specific DNA binding site [nucleotide binding]; other site 1146883004360 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 1146883004361 hypothetical protein; Provisional; Region: PRK06153 1146883004362 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1146883004363 ATP binding site [chemical binding]; other site 1146883004364 substrate interface [chemical binding]; other site 1146883004365 AAA domain; Region: AAA_13; pfam13166 1146883004366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883004367 ABC transporter signature motif; other site 1146883004368 Walker B; other site 1146883004369 D-loop; other site 1146883004370 H-loop/switch region; other site 1146883004371 AAA-like domain; Region: AAA_10; pfam12846 1146883004372 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883004373 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883004374 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1146883004375 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1146883004376 Abi-like protein; Region: Abi_2; pfam07751 1146883004377 TrwC relaxase; Region: TrwC; pfam08751 1146883004378 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883004379 AAA domain; Region: AAA_30; pfam13604 1146883004380 Family description; Region: UvrD_C_2; pfam13538 1146883004381 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1146883004382 DNA polymerase II large subunit; Provisional; Region: PRK14714 1146883004383 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1146883004384 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1146883004385 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883004386 active site 1146883004387 DNA binding site [nucleotide binding] 1146883004388 Int/Topo IB signature motif; other site 1146883004389 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1146883004390 Integrase core domain; Region: rve; pfam00665 1146883004391 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1146883004392 AAA domain; Region: AAA_22; pfam13401 1146883004393 Bacterial TniB protein; Region: TniB; pfam05621 1146883004394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883004395 putative DNA binding site [nucleotide binding]; other site 1146883004396 putative Zn2+ binding site [ion binding]; other site 1146883004397 Sodium Bile acid symporter family; Region: SBF; cl17470 1146883004398 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1146883004399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1146883004400 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1146883004401 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1146883004402 Sodium Bile acid symporter family; Region: SBF; cl17470 1146883004403 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1146883004404 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1146883004405 active site 1146883004406 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1146883004407 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1146883004408 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1146883004409 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1146883004410 active site 1146883004411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883004412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883004413 putative substrate translocation pore; other site 1146883004414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883004415 dimerization interface [polypeptide binding]; other site 1146883004416 putative DNA binding site [nucleotide binding]; other site 1146883004417 putative Zn2+ binding site [ion binding]; other site 1146883004418 SnoaL-like domain; Region: SnoaL_2; pfam12680 1146883004419 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1146883004420 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883004421 DNA binding residues [nucleotide binding] 1146883004422 dimer interface [polypeptide binding]; other site 1146883004423 metal binding site [ion binding]; metal-binding site 1146883004424 mercuric reductase; Region: MerA; TIGR02053 1146883004425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883004426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1146883004427 H+ Antiporter protein; Region: 2A0121; TIGR00900 1146883004428 Cation efflux family; Region: Cation_efflux; cl00316 1146883004429 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1146883004430 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1146883004431 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1146883004432 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1146883004433 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1146883004434 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1146883004435 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 1146883004436 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1146883004437 AhpC/TSA family; Region: AhpC-TSA; pfam00578 1146883004438 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1146883004439 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1146883004440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883004441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004442 active site 1146883004443 phosphorylation site [posttranslational modification] 1146883004444 intermolecular recognition site; other site 1146883004445 dimerization interface [polypeptide binding]; other site 1146883004446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883004447 DNA binding site [nucleotide binding] 1146883004448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883004449 HAMP domain; Region: HAMP; pfam00672 1146883004450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883004451 dimer interface [polypeptide binding]; other site 1146883004452 phosphorylation site [posttranslational modification] 1146883004453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883004454 ATP binding site [chemical binding]; other site 1146883004455 Mg2+ binding site [ion binding]; other site 1146883004456 G-X-G motif; other site 1146883004457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883004458 S-adenosylmethionine binding site [chemical binding]; other site 1146883004459 CopC domain; Region: CopC; pfam04234 1146883004460 Copper resistance protein D; Region: CopD; pfam05425 1146883004461 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1146883004462 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1146883004463 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1146883004464 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1146883004465 putative transposase OrfB; Reviewed; Region: PHA02517 1146883004466 Homeodomain-like domain; Region: HTH_32; pfam13565 1146883004467 Integrase core domain; Region: rve; pfam00665 1146883004468 Integrase core domain; Region: rve_3; pfam13683 1146883004469 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1146883004470 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1146883004471 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1146883004472 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1146883004473 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1146883004474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1146883004475 binding surface 1146883004476 TPR motif; other site 1146883004477 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1146883004478 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1146883004479 Family description; Region: DsbD_2; pfam13386 1146883004480 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1146883004481 Heavy-metal-associated domain; Region: HMA; pfam00403 1146883004482 metal-binding site [ion binding] 1146883004483 putative transposase OrfB; Reviewed; Region: PHA02517 1146883004484 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1146883004485 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1146883004486 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1146883004487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1146883004488 catalytic residues [active] 1146883004489 CcmE; Region: CcmE; pfam03100 1146883004490 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1146883004491 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1146883004492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883004493 Walker A/P-loop; other site 1146883004494 ATP binding site [chemical binding]; other site 1146883004495 Q-loop/lid; other site 1146883004496 ABC transporter signature motif; other site 1146883004497 Walker B; other site 1146883004498 D-loop; other site 1146883004499 H-loop/switch region; other site 1146883004500 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1146883004501 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1146883004502 active site residue [active] 1146883004503 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1146883004504 active site residue [active] 1146883004505 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1146883004506 Peptidase family M48; Region: Peptidase_M48; cl12018 1146883004507 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1146883004508 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1146883004509 catalytic residues [active] 1146883004510 Predicted membrane protein [Function unknown]; Region: COG3462 1146883004511 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1146883004512 putative homodimer interface [polypeptide binding]; other site 1146883004513 putative homotetramer interface [polypeptide binding]; other site 1146883004514 putative allosteric switch controlling residues; other site 1146883004515 putative metal binding site [ion binding]; other site 1146883004516 putative homodimer-homodimer interface [polypeptide binding]; other site 1146883004517 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883004518 metal-binding site [ion binding] 1146883004519 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1146883004520 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883004521 metal-binding site [ion binding] 1146883004522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883004523 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1146883004524 putative active site [active] 1146883004525 catalytic triad [active] 1146883004526 putative dimer interface [polypeptide binding]; other site 1146883004527 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1146883004528 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1146883004529 Cu(I) binding site [ion binding]; other site 1146883004530 FOG: CBS domain [General function prediction only]; Region: COG0517 1146883004531 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1146883004532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1146883004533 Rhodanese-like domain; Region: Rhodanese; pfam00581 1146883004534 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1146883004535 active site residue [active] 1146883004536 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1146883004537 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1146883004538 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883004539 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883004540 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1146883004541 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1146883004542 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1146883004543 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1146883004544 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1146883004545 dimerization interface [polypeptide binding]; other site 1146883004546 putative DNA binding site [nucleotide binding]; other site 1146883004547 putative Zn2+ binding site [ion binding]; other site 1146883004548 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1146883004549 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1146883004550 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883004551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883004552 active site 1146883004553 motif I; other site 1146883004554 motif II; other site 1146883004555 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1146883004556 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1146883004557 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1146883004558 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1146883004559 homodimer interface [polypeptide binding]; other site 1146883004560 NAD binding pocket [chemical binding]; other site 1146883004561 ATP binding pocket [chemical binding]; other site 1146883004562 Mg binding site [ion binding]; other site 1146883004563 active-site loop [active] 1146883004564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883004565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883004566 dimerization interface [polypeptide binding]; other site 1146883004567 putative DNA binding site [nucleotide binding]; other site 1146883004568 putative Zn2+ binding site [ion binding]; other site 1146883004569 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1146883004570 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1146883004571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883004572 S-adenosylmethionine binding site [chemical binding]; other site 1146883004573 Cadmium resistance transporter; Region: Cad; pfam03596 1146883004574 Domain of unknown function (DUF305); Region: DUF305; cl17794 1146883004575 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1146883004576 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1146883004577 dimerization interface [polypeptide binding]; other site 1146883004578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883004579 dimerization interface [polypeptide binding]; other site 1146883004580 putative DNA binding site [nucleotide binding]; other site 1146883004581 putative Zn2+ binding site [ion binding]; other site 1146883004582 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1146883004583 NADH dehydrogenase; Region: NADHdh; cl00469 1146883004584 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883004585 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883004586 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883004587 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883004588 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883004589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004590 active site 1146883004591 phosphorylation site [posttranslational modification] 1146883004592 intermolecular recognition site; other site 1146883004593 dimerization interface [polypeptide binding]; other site 1146883004594 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883004595 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1146883004596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883004597 active site 1146883004598 Int/Topo IB signature motif; other site 1146883004599 DNA binding site [nucleotide binding] 1146883004600 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883004601 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883004602 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1146883004603 SCP-2 sterol transfer family; Region: SCP2; cl01225 1146883004604 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1146883004605 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1146883004606 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1146883004607 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1146883004608 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1146883004609 dimer interface [polypeptide binding]; other site 1146883004610 active site 1146883004611 acyl carrier protein; Provisional; Region: acpP; PRK00982 1146883004612 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1146883004613 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1146883004614 dimer interface [polypeptide binding]; other site 1146883004615 active site 1146883004616 CoA binding pocket [chemical binding]; other site 1146883004617 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1146883004618 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1146883004619 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883004620 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883004621 Pirin; Region: Pirin; pfam02678 1146883004622 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1146883004623 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1146883004624 metal binding site [ion binding]; metal-binding site 1146883004625 dimer interface [polypeptide binding]; other site 1146883004626 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1146883004627 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1146883004628 dimer interface [polypeptide binding]; other site 1146883004629 TPP-binding site [chemical binding]; other site 1146883004630 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1146883004631 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1146883004632 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1146883004633 dimer interface [polypeptide binding]; other site 1146883004634 catalytic triad [active] 1146883004635 Ion channel; Region: Ion_trans_2; pfam07885 1146883004636 PGAP1-like protein; Region: PGAP1; pfam07819 1146883004637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883004638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883004639 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1146883004640 catalytic site [active] 1146883004641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883004642 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1146883004643 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1146883004644 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1146883004645 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1146883004646 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883004647 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1146883004648 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1146883004649 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1146883004650 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1146883004651 Carbon starvation protein CstA; Region: CstA; pfam02554 1146883004652 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1146883004653 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1146883004654 Putative zinc ribbon domain; Region: DUF164; pfam02591 1146883004655 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1146883004656 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1146883004657 RNA/DNA hybrid binding site [nucleotide binding]; other site 1146883004658 active site 1146883004659 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883004660 catalytic core [active] 1146883004661 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1146883004662 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 1146883004663 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1146883004664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883004665 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883004666 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1146883004667 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1146883004668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883004669 S-adenosylmethionine binding site [chemical binding]; other site 1146883004670 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1146883004671 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1146883004672 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1146883004673 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1146883004674 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1146883004675 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1146883004676 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1146883004677 ATP binding site [chemical binding]; other site 1146883004678 Walker A motif; other site 1146883004679 hexamer interface [polypeptide binding]; other site 1146883004680 Walker B motif; other site 1146883004681 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1146883004682 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1146883004683 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1146883004684 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1146883004685 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1146883004686 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1146883004687 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1146883004688 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1146883004689 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1146883004690 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1146883004691 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1146883004692 ATP binding site [chemical binding]; other site 1146883004693 Walker A motif; other site 1146883004694 hexamer interface [polypeptide binding]; other site 1146883004695 Walker B motif; other site 1146883004696 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1146883004697 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1146883004698 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1146883004699 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1146883004700 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1146883004701 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1146883004702 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1146883004703 active site 1146883004704 ChaB; Region: ChaB; pfam06150 1146883004705 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1146883004706 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1146883004707 active site 1146883004708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883004709 metal binding site [ion binding]; metal-binding site 1146883004710 active site 1146883004711 I-site; other site 1146883004712 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1146883004713 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1146883004714 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1146883004715 intersubunit interface [polypeptide binding]; other site 1146883004716 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1146883004717 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1146883004718 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1146883004719 oligomerization interface [polypeptide binding]; other site 1146883004720 active site 1146883004721 metal binding site [ion binding]; metal-binding site 1146883004722 NAD synthetase; Provisional; Region: PRK13981 1146883004723 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1146883004724 multimer interface [polypeptide binding]; other site 1146883004725 active site 1146883004726 catalytic triad [active] 1146883004727 protein interface 1 [polypeptide binding]; other site 1146883004728 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1146883004729 homodimer interface [polypeptide binding]; other site 1146883004730 NAD binding pocket [chemical binding]; other site 1146883004731 ATP binding pocket [chemical binding]; other site 1146883004732 Mg binding site [ion binding]; other site 1146883004733 active-site loop [active] 1146883004734 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1146883004735 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883004736 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1146883004737 MarR family; Region: MarR_2; pfam12802 1146883004738 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1146883004739 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1146883004740 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1146883004741 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1146883004742 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1146883004743 catalytic triad [active] 1146883004744 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1146883004745 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1146883004746 metal binding triad; other site 1146883004747 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1146883004748 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1146883004749 metal binding triad; other site 1146883004750 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1146883004751 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1146883004752 bile acid transporter; Region: bass; TIGR00841 1146883004753 Sodium Bile acid symporter family; Region: SBF; cl17470 1146883004754 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1146883004755 classical (c) SDRs; Region: SDR_c; cd05233 1146883004756 NAD(P) binding site [chemical binding]; other site 1146883004757 active site 1146883004758 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1146883004759 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1146883004760 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1146883004761 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883004762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1146883004763 DNA-binding site [nucleotide binding]; DNA binding site 1146883004764 HipA N-terminal domain; Region: Couple_hipA; cl11853 1146883004765 HIRAN domain; Region: HIRAN; pfam08797 1146883004766 TrwC relaxase; Region: TrwC; pfam08751 1146883004767 AAA domain; Region: AAA_30; pfam13604 1146883004768 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883004769 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1146883004770 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883004771 active site 1146883004772 DNA binding site [nucleotide binding] 1146883004773 Int/Topo IB signature motif; other site 1146883004774 glutamine synthetase, type I; Region: GlnA; TIGR00653 1146883004775 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1146883004776 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1146883004777 RDD family; Region: RDD; pfam06271 1146883004778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1146883004779 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1146883004780 lipoyl synthase; Provisional; Region: PRK05481 1146883004781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883004782 FeS/SAM binding site; other site 1146883004783 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1146883004784 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883004785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1146883004786 aminoacyl-tRNA ligase; Region: PLN02563 1146883004787 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883004788 active site 1146883004789 HIGH motif; other site 1146883004790 nucleotide binding site [chemical binding]; other site 1146883004791 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1146883004792 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883004793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883004794 active site 1146883004795 KMSKS motif; other site 1146883004796 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1146883004797 tRNA binding surface [nucleotide binding]; other site 1146883004798 anticodon binding site; other site 1146883004799 lipoate-protein ligase B; Provisional; Region: PRK14345 1146883004800 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1146883004801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883004802 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883004803 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1146883004804 active site 1146883004805 ATP binding site [chemical binding]; other site 1146883004806 substrate binding site [chemical binding]; other site 1146883004807 activation loop (A-loop); other site 1146883004808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883004809 TIGR01777 family protein; Region: yfcH 1146883004810 NAD(P) binding site [chemical binding]; other site 1146883004811 active site 1146883004812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1146883004813 E3 interaction surface; other site 1146883004814 lipoyl attachment site [posttranslational modification]; other site 1146883004815 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1146883004816 E3 interaction surface; other site 1146883004817 lipoyl attachment site [posttranslational modification]; other site 1146883004818 e3 binding domain; Region: E3_binding; pfam02817 1146883004819 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1146883004820 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1146883004821 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1146883004822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883004823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883004824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1146883004825 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1146883004826 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1146883004827 interface (dimer of trimers) [polypeptide binding]; other site 1146883004828 Substrate-binding/catalytic site; other site 1146883004829 Zn-binding sites [ion binding]; other site 1146883004830 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1146883004831 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1146883004832 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1146883004833 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1146883004834 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1146883004835 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1146883004836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883004837 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883004838 active site 1146883004839 catalytic tetrad [active] 1146883004840 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1146883004841 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1146883004842 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1146883004843 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1146883004844 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1146883004845 active site 1146883004846 dimer interface [polypeptide binding]; other site 1146883004847 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1146883004848 Ligand Binding Site [chemical binding]; other site 1146883004849 Molecular Tunnel; other site 1146883004850 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1146883004851 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1146883004852 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1146883004853 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1146883004854 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1146883004855 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1146883004856 heme bH binding site [chemical binding]; other site 1146883004857 intrachain domain interface; other site 1146883004858 heme bL binding site [chemical binding]; other site 1146883004859 interchain domain interface [polypeptide binding]; other site 1146883004860 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1146883004861 Qo binding site; other site 1146883004862 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1146883004863 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1146883004864 iron-sulfur cluster [ion binding]; other site 1146883004865 [2Fe-2S] cluster binding site [ion binding]; other site 1146883004866 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1146883004867 Cytochrome c; Region: Cytochrom_C; pfam00034 1146883004868 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1146883004869 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1146883004870 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1146883004871 Subunit I/III interface [polypeptide binding]; other site 1146883004872 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1146883004873 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1146883004874 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1146883004875 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1146883004876 AsnC family; Region: AsnC_trans_reg; pfam01037 1146883004877 hypothetical protein; Validated; Region: PRK07883 1146883004878 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1146883004879 active site 1146883004880 catalytic site [active] 1146883004881 substrate binding site [chemical binding]; other site 1146883004882 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1146883004883 GIY-YIG motif/motif A; other site 1146883004884 active site 1146883004885 catalytic site [active] 1146883004886 putative DNA binding site [nucleotide binding]; other site 1146883004887 metal binding site [ion binding]; metal-binding site 1146883004888 NlpC/P60 family; Region: NLPC_P60; cl17555 1146883004889 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1146883004890 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883004891 NlpC/P60 family; Region: NLPC_P60; pfam00877 1146883004892 Peptidase family M48; Region: Peptidase_M48; cl12018 1146883004893 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883004894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883004895 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1146883004896 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1146883004897 acyl-activating enzyme (AAE) consensus motif; other site 1146883004898 putative AMP binding site [chemical binding]; other site 1146883004899 putative active site [active] 1146883004900 putative CoA binding site [chemical binding]; other site 1146883004901 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1146883004902 putative hydrophobic ligand binding site [chemical binding]; other site 1146883004903 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1146883004904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1146883004905 nucleotide binding site [chemical binding]; other site 1146883004906 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 1146883004907 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1146883004908 homodimer interface [polypeptide binding]; other site 1146883004909 Esterase/lipase [General function prediction only]; Region: COG1647 1146883004910 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1146883004911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1146883004912 putative acyl-acceptor binding pocket; other site 1146883004913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883004914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883004915 ATP binding site [chemical binding]; other site 1146883004916 Mg2+ binding site [ion binding]; other site 1146883004917 G-X-G motif; other site 1146883004918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883004919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883004920 active site 1146883004921 phosphorylation site [posttranslational modification] 1146883004922 intermolecular recognition site; other site 1146883004923 dimerization interface [polypeptide binding]; other site 1146883004924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883004925 DNA binding residues [nucleotide binding] 1146883004926 dimerization interface [polypeptide binding]; other site 1146883004927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883004928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883004929 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883004930 putative hydrolase; Provisional; Region: PRK11460 1146883004931 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883004932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1146883004933 short chain dehydrogenase; Provisional; Region: PRK05872 1146883004934 classical (c) SDRs; Region: SDR_c; cd05233 1146883004935 NAD(P) binding site [chemical binding]; other site 1146883004936 active site 1146883004937 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1146883004938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883004939 dimerization interface [polypeptide binding]; other site 1146883004940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1146883004941 putative CheW interface [polypeptide binding]; other site 1146883004942 phosphofructokinase; Region: PFK_mixed; TIGR02483 1146883004943 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1146883004944 active site 1146883004945 ADP/pyrophosphate binding site [chemical binding]; other site 1146883004946 dimerization interface [polypeptide binding]; other site 1146883004947 allosteric effector site; other site 1146883004948 fructose-1,6-bisphosphate binding site; other site 1146883004949 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1146883004950 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1146883004951 tetramer interface [polypeptide binding]; other site 1146883004952 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1146883004953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883004954 catalytic residue [active] 1146883004955 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1146883004956 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1146883004957 putative active site [active] 1146883004958 AP endonuclease family 2; Region: AP2Ec; smart00518 1146883004959 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1146883004960 AP (apurinic/apyrimidinic) site pocket; other site 1146883004961 DNA interaction; other site 1146883004962 Metal-binding active site; metal-binding site 1146883004963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883004964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1146883004965 active site 1146883004966 ATP binding site [chemical binding]; other site 1146883004967 substrate binding site [chemical binding]; other site 1146883004968 activation loop (A-loop); other site 1146883004969 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1146883004970 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883004971 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883004972 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883004973 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1146883004974 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1146883004975 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1146883004976 active site 1146883004977 substrate binding site [chemical binding]; other site 1146883004978 FMN binding site [chemical binding]; other site 1146883004979 putative catalytic residues [active] 1146883004980 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883004981 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1146883004982 active site lid residues [active] 1146883004983 substrate binding pocket [chemical binding]; other site 1146883004984 catalytic residues [active] 1146883004985 substrate-Mg2+ binding site; other site 1146883004986 aspartate-rich region 1; other site 1146883004987 aspartate-rich region 2; other site 1146883004988 phytoene desaturase; Region: crtI_fam; TIGR02734 1146883004989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883004990 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1146883004991 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1146883004992 substrate binding pocket [chemical binding]; other site 1146883004993 chain length determination region; other site 1146883004994 substrate-Mg2+ binding site; other site 1146883004995 catalytic residues [active] 1146883004996 aspartate-rich region 1; other site 1146883004997 active site lid residues [active] 1146883004998 aspartate-rich region 2; other site 1146883004999 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1146883005000 FAD binding site [chemical binding]; other site 1146883005001 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1146883005002 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1146883005003 putative active site [active] 1146883005004 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1146883005005 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1146883005006 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1146883005007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883005008 ATP binding site [chemical binding]; other site 1146883005009 putative Mg++ binding site [ion binding]; other site 1146883005010 Fic/DOC family; Region: Fic; cl00960 1146883005011 AAA domain; Region: AAA_31; pfam13614 1146883005012 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1146883005013 P-loop; other site 1146883005014 Magnesium ion binding site [ion binding]; other site 1146883005015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1146883005016 Magnesium ion binding site [ion binding]; other site 1146883005017 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1146883005018 Divergent AAA domain; Region: AAA_4; pfam04326 1146883005019 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1146883005020 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1146883005021 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1146883005022 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1146883005023 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1146883005024 S-adenosylmethionine binding site [chemical binding]; other site 1146883005025 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1146883005026 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1146883005027 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883005028 GAF domain; Region: GAF; pfam01590 1146883005029 GAF domain; Region: GAF; cl17456 1146883005030 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883005031 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1146883005032 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1146883005033 substrate binding pocket [chemical binding]; other site 1146883005034 catalytic triad [active] 1146883005035 PGAP1-like protein; Region: PGAP1; pfam07819 1146883005036 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1146883005037 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1146883005038 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1146883005039 substrate binding site [chemical binding]; other site 1146883005040 ATP binding site [chemical binding]; other site 1146883005041 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1146883005042 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1146883005043 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1146883005044 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1146883005045 active site 1146883005046 Protein of unknown function (DUF422); Region: DUF422; cl00991 1146883005047 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1146883005048 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1146883005049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883005050 Coenzyme A binding pocket [chemical binding]; other site 1146883005051 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1146883005052 putative deacylase active site [active] 1146883005053 PemK-like protein; Region: PemK; pfam02452 1146883005054 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1146883005055 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1146883005056 active site 1146883005057 PHP Thumb interface [polypeptide binding]; other site 1146883005058 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1146883005059 generic binding surface II; other site 1146883005060 generic binding surface I; other site 1146883005061 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1146883005062 dimer interface [polypeptide binding]; other site 1146883005063 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1146883005064 putative dimer interface [polypeptide binding]; other site 1146883005065 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883005066 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1146883005067 putative active site [active] 1146883005068 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883005069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883005070 S-adenosylmethionine binding site [chemical binding]; other site 1146883005071 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1146883005072 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1146883005073 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1146883005074 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1146883005075 putative dimer interface [polypeptide binding]; other site 1146883005076 putative [2Fe-2S] cluster binding site [ion binding]; other site 1146883005077 Cupin superfamily protein; Region: Cupin_4; pfam08007 1146883005078 Cupin-like domain; Region: Cupin_8; pfam13621 1146883005079 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1146883005080 active site 1146883005081 DNA polymerase IV; Validated; Region: PRK02406 1146883005082 DNA binding site [nucleotide binding] 1146883005083 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1146883005084 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1146883005085 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1146883005086 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1146883005087 Protein of unknown function DUF58; Region: DUF58; pfam01882 1146883005088 MoxR-like ATPases [General function prediction only]; Region: COG0714 1146883005089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883005090 Walker A motif; other site 1146883005091 ATP binding site [chemical binding]; other site 1146883005092 Walker B motif; other site 1146883005093 arginine finger; other site 1146883005094 cell division protein MraZ; Reviewed; Region: PRK00326 1146883005095 MraZ protein; Region: MraZ; pfam02381 1146883005096 MraZ protein; Region: MraZ; pfam02381 1146883005097 MraW methylase family; Region: Methyltransf_5; cl17771 1146883005098 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1146883005099 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1146883005100 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1146883005101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1146883005102 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1146883005103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1146883005104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1146883005105 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1146883005106 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1146883005107 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1146883005108 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1146883005109 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1146883005110 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1146883005111 Mg++ binding site [ion binding]; other site 1146883005112 putative catalytic motif [active] 1146883005113 putative substrate binding site [chemical binding]; other site 1146883005114 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1146883005115 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1146883005116 cell division protein FtsW; Region: ftsW; TIGR02614 1146883005117 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1146883005118 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1146883005119 active site 1146883005120 homodimer interface [polypeptide binding]; other site 1146883005121 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1146883005122 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1146883005123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1146883005124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1146883005125 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1146883005126 Cell division protein FtsQ; Region: FtsQ; pfam03799 1146883005127 cell division protein FtsZ; Validated; Region: PRK09330 1146883005128 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1146883005129 nucleotide binding site [chemical binding]; other site 1146883005130 SulA interaction site; other site 1146883005131 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1146883005132 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1146883005133 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1146883005134 Probable transposase; Region: OrfB_IS605; pfam01385 1146883005135 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1146883005136 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1146883005137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1146883005138 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1146883005139 catalytic residue [active] 1146883005140 Protein of unknown function (DUF552); Region: DUF552; cl00775 1146883005141 YGGT family; Region: YGGT; pfam02325 1146883005142 DivIVA protein; Region: DivIVA; pfam05103 1146883005143 DivIVA domain; Region: DivI1A_domain; TIGR03544 1146883005144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1146883005145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883005146 dimer interface [polypeptide binding]; other site 1146883005147 ABC-ATPase subunit interface; other site 1146883005148 putative PBP binding loops; other site 1146883005149 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1146883005150 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1146883005151 Walker A/P-loop; other site 1146883005152 ATP binding site [chemical binding]; other site 1146883005153 Q-loop/lid; other site 1146883005154 ABC transporter signature motif; other site 1146883005155 Walker B; other site 1146883005156 D-loop; other site 1146883005157 H-loop/switch region; other site 1146883005158 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1146883005159 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883005160 active site 1146883005161 HIGH motif; other site 1146883005162 nucleotide binding site [chemical binding]; other site 1146883005163 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1146883005164 active site 1146883005165 KMSKS motif; other site 1146883005166 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1146883005167 tRNA binding surface [nucleotide binding]; other site 1146883005168 anticodon binding site; other site 1146883005169 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883005170 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1146883005171 oligomeric interface; other site 1146883005172 putative active site [active] 1146883005173 homodimer interface [polypeptide binding]; other site 1146883005174 potassium/proton antiporter; Reviewed; Region: PRK05326 1146883005175 TrkA-C domain; Region: TrkA_C; pfam02080 1146883005176 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1146883005177 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1146883005178 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1146883005179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1146883005180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883005181 dimer interface [polypeptide binding]; other site 1146883005182 conserved gate region; other site 1146883005183 putative PBP binding loops; other site 1146883005184 ABC-ATPase subunit interface; other site 1146883005185 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1146883005186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883005187 dimer interface [polypeptide binding]; other site 1146883005188 conserved gate region; other site 1146883005189 ABC-ATPase subunit interface; other site 1146883005190 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1146883005191 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1146883005192 Walker A/P-loop; other site 1146883005193 ATP binding site [chemical binding]; other site 1146883005194 Q-loop/lid; other site 1146883005195 ABC transporter signature motif; other site 1146883005196 Walker B; other site 1146883005197 D-loop; other site 1146883005198 H-loop/switch region; other site 1146883005199 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1146883005200 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1146883005201 active site 1146883005202 catalytic site [active] 1146883005203 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1146883005204 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1146883005205 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1146883005206 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1146883005207 active site 1146883005208 CAAX protease self-immunity; Region: Abi; pfam02517 1146883005209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1146883005210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1146883005211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883005212 Coenzyme A binding pocket [chemical binding]; other site 1146883005213 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1146883005214 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1146883005215 active site 1146883005216 PHP Thumb interface [polypeptide binding]; other site 1146883005217 metal binding site [ion binding]; metal-binding site 1146883005218 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1146883005219 generic binding surface II; other site 1146883005220 generic binding surface I; other site 1146883005221 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1146883005222 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1146883005223 acyl-activating enzyme (AAE) consensus motif; other site 1146883005224 putative AMP binding site [chemical binding]; other site 1146883005225 putative active site [active] 1146883005226 putative CoA binding site [chemical binding]; other site 1146883005227 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1146883005228 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1146883005229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883005230 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1146883005231 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883005232 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1146883005233 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1146883005234 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1146883005235 NAD binding site [chemical binding]; other site 1146883005236 dimerization interface [polypeptide binding]; other site 1146883005237 product binding site; other site 1146883005238 substrate binding site [chemical binding]; other site 1146883005239 zinc binding site [ion binding]; other site 1146883005240 catalytic residues [active] 1146883005241 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1146883005242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883005243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883005244 homodimer interface [polypeptide binding]; other site 1146883005245 catalytic residue [active] 1146883005246 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1146883005247 putative active site pocket [active] 1146883005248 4-fold oligomerization interface [polypeptide binding]; other site 1146883005249 metal binding residues [ion binding]; metal-binding site 1146883005250 3-fold/trimer interface [polypeptide binding]; other site 1146883005251 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1146883005252 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1146883005253 putative active site [active] 1146883005254 oxyanion strand; other site 1146883005255 catalytic triad [active] 1146883005256 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883005257 classical (c) SDRs; Region: SDR_c; cd05233 1146883005258 NAD(P) binding site [chemical binding]; other site 1146883005259 active site 1146883005260 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1146883005261 FMN binding site [chemical binding]; other site 1146883005262 dimer interface [polypeptide binding]; other site 1146883005263 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1146883005264 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1146883005265 catalytic residues [active] 1146883005266 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1146883005267 homotrimer interaction site [polypeptide binding]; other site 1146883005268 putative active site [active] 1146883005269 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1146883005270 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1146883005271 substrate binding site [chemical binding]; other site 1146883005272 glutamase interaction surface [polypeptide binding]; other site 1146883005273 TIGR03085 family protein; Region: TIGR03085 1146883005274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1146883005275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883005276 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1146883005277 Walker A/P-loop; other site 1146883005278 ATP binding site [chemical binding]; other site 1146883005279 Q-loop/lid; other site 1146883005280 ABC transporter signature motif; other site 1146883005281 Walker B; other site 1146883005282 D-loop; other site 1146883005283 H-loop/switch region; other site 1146883005284 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1146883005285 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1146883005286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883005287 Walker A/P-loop; other site 1146883005288 ATP binding site [chemical binding]; other site 1146883005289 Q-loop/lid; other site 1146883005290 ABC transporter signature motif; other site 1146883005291 Walker B; other site 1146883005292 D-loop; other site 1146883005293 H-loop/switch region; other site 1146883005294 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1146883005295 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1146883005296 FAD binding domain; Region: FAD_binding_2; pfam00890 1146883005297 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1146883005298 anthranilate synthase component I; Provisional; Region: PRK13571 1146883005299 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1146883005300 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1146883005301 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1146883005302 active site 1146883005303 ribulose/triose binding site [chemical binding]; other site 1146883005304 phosphate binding site [ion binding]; other site 1146883005305 substrate (anthranilate) binding pocket [chemical binding]; other site 1146883005306 product (indole) binding pocket [chemical binding]; other site 1146883005307 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883005308 active site 1146883005309 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1146883005310 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1146883005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883005312 catalytic residue [active] 1146883005313 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1146883005314 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1146883005315 substrate binding site [chemical binding]; other site 1146883005316 active site 1146883005317 catalytic residues [active] 1146883005318 heterodimer interface [polypeptide binding]; other site 1146883005319 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1146883005320 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1146883005321 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1146883005322 active site 1146883005323 dimer interface [polypeptide binding]; other site 1146883005324 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1146883005325 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1146883005326 active site 1146883005327 FMN binding site [chemical binding]; other site 1146883005328 substrate binding site [chemical binding]; other site 1146883005329 3Fe-4S cluster binding site [ion binding]; other site 1146883005330 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1146883005331 domain interface; other site 1146883005332 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1146883005333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883005334 pyruvate kinase; Provisional; Region: PRK06247 1146883005335 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1146883005336 domain interfaces; other site 1146883005337 active site 1146883005338 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1146883005339 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1146883005340 active site 1146883005341 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1146883005342 catalytic triad [active] 1146883005343 dimer interface [polypeptide binding]; other site 1146883005344 tyrosine decarboxylase; Region: PLN02880 1146883005345 Pyridoxal-dependent decarboxylase conserved domain; Region: Pyridoxal_deC; pfam00282 1146883005346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883005347 catalytic residue [active] 1146883005348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883005349 S-adenosylmethionine binding site [chemical binding]; other site 1146883005350 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1146883005351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883005352 active site 1146883005353 phosphorylation site [posttranslational modification] 1146883005354 intermolecular recognition site; other site 1146883005355 dimerization interface [polypeptide binding]; other site 1146883005356 ANTAR domain; Region: ANTAR; pfam03861 1146883005357 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1146883005358 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883005359 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883005360 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883005361 Walker A/P-loop; other site 1146883005362 ATP binding site [chemical binding]; other site 1146883005363 Q-loop/lid; other site 1146883005364 ABC transporter signature motif; other site 1146883005365 Walker B; other site 1146883005366 D-loop; other site 1146883005367 H-loop/switch region; other site 1146883005368 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883005369 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883005370 Walker A/P-loop; other site 1146883005371 ATP binding site [chemical binding]; other site 1146883005372 Q-loop/lid; other site 1146883005373 ABC transporter signature motif; other site 1146883005374 Walker B; other site 1146883005375 D-loop; other site 1146883005376 H-loop/switch region; other site 1146883005377 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883005378 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883005379 TM-ABC transporter signature motif; other site 1146883005380 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1146883005381 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883005382 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883005383 TM-ABC transporter signature motif; other site 1146883005384 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883005385 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1146883005386 CoenzymeA binding site [chemical binding]; other site 1146883005387 subunit interaction site [polypeptide binding]; other site 1146883005388 PHB binding site; other site 1146883005389 DNA polymerase I; Provisional; Region: PRK05755 1146883005390 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1146883005391 active site 1146883005392 metal binding site 1 [ion binding]; metal-binding site 1146883005393 putative 5' ssDNA interaction site; other site 1146883005394 metal binding site 3; metal-binding site 1146883005395 metal binding site 2 [ion binding]; metal-binding site 1146883005396 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1146883005397 putative DNA binding site [nucleotide binding]; other site 1146883005398 putative metal binding site [ion binding]; other site 1146883005399 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1146883005400 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1146883005401 active site 1146883005402 DNA binding site [nucleotide binding] 1146883005403 catalytic site [active] 1146883005404 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1146883005405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883005406 S-adenosylmethionine binding site [chemical binding]; other site 1146883005407 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1146883005408 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1146883005409 RNA binding site [nucleotide binding]; other site 1146883005410 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1146883005411 RNA binding site [nucleotide binding]; other site 1146883005412 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1146883005413 RNA binding site [nucleotide binding]; other site 1146883005414 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1146883005415 RNA binding site [nucleotide binding]; other site 1146883005416 domain interface; other site 1146883005417 dephospho-CoA kinase; Region: TIGR00152 1146883005418 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1146883005419 CoA-binding site [chemical binding]; other site 1146883005420 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1146883005421 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1146883005422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883005423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883005424 DNA binding residues [nucleotide binding] 1146883005425 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1146883005426 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1146883005427 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1146883005428 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1146883005429 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1146883005430 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1146883005431 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1146883005432 HNH endonuclease; Region: HNH; pfam01844 1146883005433 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1146883005434 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1146883005435 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1146883005436 putative active site [active] 1146883005437 putative metal binding site [ion binding]; other site 1146883005438 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1146883005439 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1146883005440 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1146883005441 active site 1146883005442 dimer interface [polypeptide binding]; other site 1146883005443 motif 1; other site 1146883005444 motif 2; other site 1146883005445 motif 3; other site 1146883005446 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1146883005447 anticodon binding site; other site 1146883005448 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1146883005449 nucleotide binding site/active site [active] 1146883005450 HIT family signature motif; other site 1146883005451 catalytic residue [active] 1146883005452 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1146883005453 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1146883005454 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1146883005455 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1146883005456 putative acyl-acceptor binding pocket; other site 1146883005457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883005458 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883005459 LemA family; Region: LemA; cl00742 1146883005460 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1146883005461 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1146883005462 active site 1146883005463 multimer interface [polypeptide binding]; other site 1146883005464 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1146883005465 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 1146883005466 predicted active site [active] 1146883005467 catalytic triad [active] 1146883005468 hypothetical protein; Validated; Region: PRK00110 1146883005469 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1146883005470 active site 1146883005471 putative DNA-binding cleft [nucleotide binding]; other site 1146883005472 dimer interface [polypeptide binding]; other site 1146883005473 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1146883005474 RuvA N terminal domain; Region: RuvA_N; pfam01330 1146883005475 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1146883005476 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1146883005477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883005478 Walker A motif; other site 1146883005479 ATP binding site [chemical binding]; other site 1146883005480 Walker B motif; other site 1146883005481 arginine finger; other site 1146883005482 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1146883005483 Preprotein translocase subunit; Region: YajC; pfam02699 1146883005484 protein-export membrane protein SecD; Region: secD; TIGR01129 1146883005485 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1146883005486 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1146883005487 Protein export membrane protein; Region: SecD_SecF; pfam02355 1146883005488 adenine phosphoribosyltransferase; Provisional; Region: PRK02304 1146883005489 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1146883005490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1146883005491 Zn2+ binding site [ion binding]; other site 1146883005492 Mg2+ binding site [ion binding]; other site 1146883005493 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1146883005494 synthetase active site [active] 1146883005495 NTP binding site [chemical binding]; other site 1146883005496 metal binding site [ion binding]; metal-binding site 1146883005497 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1146883005498 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1146883005499 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1146883005500 active site 1146883005501 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1146883005502 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1146883005503 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1146883005504 dimer interface [polypeptide binding]; other site 1146883005505 motif 1; other site 1146883005506 active site 1146883005507 motif 2; other site 1146883005508 motif 3; other site 1146883005509 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1146883005510 anticodon binding site; other site 1146883005511 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883005512 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883005513 active site 1146883005514 catalytic tetrad [active] 1146883005515 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1146883005516 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1146883005517 dimer interface [polypeptide binding]; other site 1146883005518 anticodon binding site; other site 1146883005519 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1146883005520 homodimer interface [polypeptide binding]; other site 1146883005521 motif 1; other site 1146883005522 active site 1146883005523 motif 2; other site 1146883005524 GAD domain; Region: GAD; pfam02938 1146883005525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1146883005526 active site 1146883005527 motif 3; other site 1146883005528 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1146883005529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883005530 catalytic residue [active] 1146883005531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883005532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883005533 active site 1146883005534 catalytic tetrad [active] 1146883005535 recombination factor protein RarA; Reviewed; Region: PRK13342 1146883005536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883005537 Walker A motif; other site 1146883005538 ATP binding site [chemical binding]; other site 1146883005539 Walker B motif; other site 1146883005540 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1146883005541 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1146883005542 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1146883005543 motif 1; other site 1146883005544 active site 1146883005545 motif 2; other site 1146883005546 motif 3; other site 1146883005547 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1146883005548 DHHA1 domain; Region: DHHA1; pfam02272 1146883005549 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1146883005550 YceG-like family; Region: YceG; pfam02618 1146883005551 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1146883005552 dimerization interface [polypeptide binding]; other site 1146883005553 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1146883005554 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1146883005555 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1146883005556 shikimate binding site; other site 1146883005557 NAD(P) binding site [chemical binding]; other site 1146883005558 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1146883005559 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1146883005560 Tetramer interface [polypeptide binding]; other site 1146883005561 active site 1146883005562 FMN-binding site [chemical binding]; other site 1146883005563 shikimate kinase; Reviewed; Region: aroK; PRK00131 1146883005564 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1146883005565 active site 1146883005566 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1146883005567 active site 1146883005568 dimer interface [polypeptide binding]; other site 1146883005569 metal binding site [ion binding]; metal-binding site 1146883005570 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1146883005571 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1146883005572 trimer interface [polypeptide binding]; other site 1146883005573 active site 1146883005574 dimer interface [polypeptide binding]; other site 1146883005575 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1146883005576 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1146883005577 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1146883005578 active site 1146883005579 elongation factor P; Validated; Region: PRK00529 1146883005580 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1146883005581 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1146883005582 RNA binding site [nucleotide binding]; other site 1146883005583 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1146883005584 RNA binding site [nucleotide binding]; other site 1146883005585 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1146883005586 putative RNA binding site [nucleotide binding]; other site 1146883005587 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1146883005588 putative active site [active] 1146883005589 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883005590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883005591 Walker A/P-loop; other site 1146883005592 ATP binding site [chemical binding]; other site 1146883005593 Q-loop/lid; other site 1146883005594 ABC transporter signature motif; other site 1146883005595 Walker B; other site 1146883005596 D-loop; other site 1146883005597 H-loop/switch region; other site 1146883005598 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883005599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883005600 non-specific DNA binding site [nucleotide binding]; other site 1146883005601 salt bridge; other site 1146883005602 sequence-specific DNA binding site [nucleotide binding]; other site 1146883005603 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1146883005604 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1146883005605 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1146883005606 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1146883005607 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1146883005608 dihydroorotase; Validated; Region: pyrC; PRK09357 1146883005609 Amidohydrolase; Region: Amidohydro_5; pfam13594 1146883005610 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1146883005611 active site 1146883005612 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1146883005613 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1146883005614 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1146883005615 catalytic site [active] 1146883005616 subunit interface [polypeptide binding]; other site 1146883005617 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1146883005618 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883005619 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883005620 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1146883005621 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883005622 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883005623 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1146883005624 IMP binding site; other site 1146883005625 dimer interface [polypeptide binding]; other site 1146883005626 interdomain contacts; other site 1146883005627 partial ornithine binding site; other site 1146883005628 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883005629 phosphate binding site [ion binding]; other site 1146883005630 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1146883005631 active site 1146883005632 dimer interface [polypeptide binding]; other site 1146883005633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883005634 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1146883005635 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1146883005636 active site 1146883005637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883005638 GAF domain; Region: GAF; cl17456 1146883005639 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883005640 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1146883005641 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1146883005642 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1146883005643 catalytic site [active] 1146883005644 G-X2-G-X-G-K; other site 1146883005645 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1146883005646 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1146883005647 Flavoprotein; Region: Flavoprotein; pfam02441 1146883005648 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1146883005649 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1146883005650 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1146883005651 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1146883005652 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1146883005653 primosome assembly protein PriA; Provisional; Region: PRK14873 1146883005654 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1146883005655 active site 1146883005656 catalytic residues [active] 1146883005657 metal binding site [ion binding]; metal-binding site 1146883005658 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1146883005659 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1146883005660 putative active site [active] 1146883005661 substrate binding site [chemical binding]; other site 1146883005662 putative cosubstrate binding site; other site 1146883005663 catalytic site [active] 1146883005664 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1146883005665 substrate binding site [chemical binding]; other site 1146883005666 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1146883005667 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1146883005668 putative RNA binding site [nucleotide binding]; other site 1146883005669 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1146883005670 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1146883005671 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1146883005672 substrate binding site [chemical binding]; other site 1146883005673 hexamer interface [polypeptide binding]; other site 1146883005674 metal binding site [ion binding]; metal-binding site 1146883005675 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1146883005676 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1146883005677 catalytic motif [active] 1146883005678 Zn binding site [ion binding]; other site 1146883005679 RibD C-terminal domain; Region: RibD_C; pfam01872 1146883005680 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1146883005681 Lumazine binding domain; Region: Lum_binding; pfam00677 1146883005682 Lumazine binding domain; Region: Lum_binding; pfam00677 1146883005683 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1146883005684 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1146883005685 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1146883005686 dimerization interface [polypeptide binding]; other site 1146883005687 active site 1146883005688 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1146883005689 homopentamer interface [polypeptide binding]; other site 1146883005690 active site 1146883005691 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1146883005692 homodimer interface [polypeptide binding]; other site 1146883005693 putative metal binding site [ion binding]; other site 1146883005694 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1146883005695 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1146883005696 HisG, C-terminal domain; Region: HisG_C; pfam08029 1146883005697 Subtilisin inhibitor-like; Region: SSI; cl11594 1146883005698 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1146883005699 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1146883005700 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883005701 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1146883005702 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 1146883005703 NADP binding site [chemical binding]; other site 1146883005704 homotetramer interface [polypeptide binding]; other site 1146883005705 homodimer interface [polypeptide binding]; other site 1146883005706 active site 1146883005707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883005708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883005709 non-specific DNA binding site [nucleotide binding]; other site 1146883005710 salt bridge; other site 1146883005711 sequence-specific DNA binding site [nucleotide binding]; other site 1146883005712 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1146883005713 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1146883005714 putative active site [active] 1146883005715 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1146883005716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883005717 NAD(P) binding site [chemical binding]; other site 1146883005718 active site 1146883005719 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1146883005720 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1146883005721 PAS domain; Region: PAS; smart00091 1146883005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883005723 ATP binding site [chemical binding]; other site 1146883005724 G-X-G motif; other site 1146883005725 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1146883005726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883005727 active site 1146883005728 phosphorylation site [posttranslational modification] 1146883005729 intermolecular recognition site; other site 1146883005730 dimerization interface [polypeptide binding]; other site 1146883005731 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1146883005732 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1146883005733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1146883005734 Membrane transport protein; Region: Mem_trans; cl09117 1146883005735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1146883005736 hypothetical protein; Provisional; Region: PRK10621 1146883005737 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1146883005738 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1146883005739 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1146883005740 trehalose synthase; Region: treS_nterm; TIGR02456 1146883005741 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1146883005742 active site 1146883005743 catalytic site [active] 1146883005744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883005745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883005746 ATP binding site [chemical binding]; other site 1146883005747 putative Mg++ binding site [ion binding]; other site 1146883005748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883005749 nucleotide binding region [chemical binding]; other site 1146883005750 ATP-binding site [chemical binding]; other site 1146883005751 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1146883005752 short chain dehydrogenase; Provisional; Region: PRK06701 1146883005753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883005754 NAD(P) binding site [chemical binding]; other site 1146883005755 active site 1146883005756 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1146883005757 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1146883005758 Haemolytic domain; Region: Haemolytic; pfam01809 1146883005759 hypothetical protein; Provisional; Region: PRK09256 1146883005760 PRC-barrel domain; Region: PRC; pfam05239 1146883005761 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1146883005762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883005763 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1146883005764 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1146883005765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883005766 non-specific DNA binding site [nucleotide binding]; other site 1146883005767 salt bridge; other site 1146883005768 sequence-specific DNA binding site [nucleotide binding]; other site 1146883005769 Cupin domain; Region: Cupin_2; pfam07883 1146883005770 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1146883005771 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1146883005772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883005773 S-adenosylmethionine binding site [chemical binding]; other site 1146883005774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883005775 Coenzyme A binding pocket [chemical binding]; other site 1146883005776 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1146883005777 DNA binding site [nucleotide binding] 1146883005778 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1146883005779 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1146883005780 active site 1146883005781 hypothetical protein; Provisional; Region: PRK06547 1146883005782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883005783 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1146883005784 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1146883005785 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1146883005786 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1146883005787 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1146883005788 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1146883005789 23S rRNA binding site [nucleotide binding]; other site 1146883005790 L21 binding site [polypeptide binding]; other site 1146883005791 L13 binding site [polypeptide binding]; other site 1146883005792 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1146883005793 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1146883005794 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1146883005795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883005796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883005797 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883005798 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1146883005799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883005800 PAS domain; Region: PAS_9; pfam13426 1146883005801 putative active site [active] 1146883005802 heme pocket [chemical binding]; other site 1146883005803 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883005804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883005805 metal binding site [ion binding]; metal-binding site 1146883005806 active site 1146883005807 I-site; other site 1146883005808 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1146883005809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1146883005810 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1146883005811 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1146883005812 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1146883005813 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1146883005814 dimer interface [polypeptide binding]; other site 1146883005815 motif 1; other site 1146883005816 active site 1146883005817 motif 2; other site 1146883005818 motif 3; other site 1146883005819 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1146883005820 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1146883005821 putative tRNA-binding site [nucleotide binding]; other site 1146883005822 B3/4 domain; Region: B3_4; pfam03483 1146883005823 tRNA synthetase B5 domain; Region: B5; smart00874 1146883005824 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1146883005825 dimer interface [polypeptide binding]; other site 1146883005826 motif 1; other site 1146883005827 motif 3; other site 1146883005828 motif 2; other site 1146883005829 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1146883005830 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1146883005831 classical (c) SDRs; Region: SDR_c; cd05233 1146883005832 NAD(P) binding site [chemical binding]; other site 1146883005833 active site 1146883005834 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1146883005835 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1146883005836 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1146883005837 heterotetramer interface [polypeptide binding]; other site 1146883005838 active site pocket [active] 1146883005839 cleavage site 1146883005840 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1146883005841 feedback inhibition sensing region; other site 1146883005842 homohexameric interface [polypeptide binding]; other site 1146883005843 nucleotide binding site [chemical binding]; other site 1146883005844 N-acetyl-L-glutamate binding site [chemical binding]; other site 1146883005845 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1146883005846 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1146883005847 inhibitor-cofactor binding pocket; inhibition site 1146883005848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883005849 catalytic residue [active] 1146883005850 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1146883005851 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1146883005852 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1146883005853 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1146883005854 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1146883005855 argininosuccinate lyase; Provisional; Region: PRK00855 1146883005856 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1146883005857 active sites [active] 1146883005858 tetramer interface [polypeptide binding]; other site 1146883005859 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1146883005860 active site 1146883005861 DNA binding site [nucleotide binding] 1146883005862 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1146883005863 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1146883005864 active site 1146883005865 HIGH motif; other site 1146883005866 dimer interface [polypeptide binding]; other site 1146883005867 KMSKS motif; other site 1146883005868 S4 RNA-binding domain; Region: S4; smart00363 1146883005869 RNA binding surface [nucleotide binding]; other site 1146883005870 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1146883005871 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1146883005872 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1146883005873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883005874 motif II; other site 1146883005875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883005876 SCP-2 sterol transfer family; Region: SCP2; cl01225 1146883005877 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1146883005878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1146883005879 RNA binding surface [nucleotide binding]; other site 1146883005880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883005881 S-adenosylmethionine binding site [chemical binding]; other site 1146883005882 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1146883005883 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1146883005884 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1146883005885 Walker A/P-loop; other site 1146883005886 ATP binding site [chemical binding]; other site 1146883005887 Q-loop/lid; other site 1146883005888 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1146883005889 ABC transporter signature motif; other site 1146883005890 Walker B; other site 1146883005891 D-loop; other site 1146883005892 H-loop/switch region; other site 1146883005893 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1146883005894 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1146883005895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883005896 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1146883005897 Thiamine pyrophosphokinase; Region: TPK; cl08415 1146883005898 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1146883005899 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1146883005900 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1146883005901 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1146883005902 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883005903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883005904 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1146883005905 CTP synthetase; Validated; Region: pyrG; PRK05380 1146883005906 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1146883005907 Catalytic site [active] 1146883005908 active site 1146883005909 UTP binding site [chemical binding]; other site 1146883005910 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1146883005911 active site 1146883005912 putative oxyanion hole; other site 1146883005913 catalytic triad [active] 1146883005914 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1146883005915 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1146883005916 dimer interface [polypeptide binding]; other site 1146883005917 active site 1146883005918 ADP-ribose binding site [chemical binding]; other site 1146883005919 nudix motif; other site 1146883005920 metal binding site [ion binding]; metal-binding site 1146883005921 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1146883005922 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1146883005923 hexamer interface [polypeptide binding]; other site 1146883005924 ligand binding site [chemical binding]; other site 1146883005925 putative active site [active] 1146883005926 NAD(P) binding site [chemical binding]; other site 1146883005927 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1146883005928 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883005929 active site 1146883005930 DNA binding site [nucleotide binding] 1146883005931 Int/Topo IB signature motif; other site 1146883005932 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1146883005933 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1146883005934 P-loop; other site 1146883005935 Magnesium ion binding site [ion binding]; other site 1146883005936 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1146883005937 Magnesium ion binding site [ion binding]; other site 1146883005938 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1146883005939 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1146883005940 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1146883005941 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1146883005942 RNA binding surface [nucleotide binding]; other site 1146883005943 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1146883005944 active site 1146883005945 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1146883005946 homotrimer interaction site [polypeptide binding]; other site 1146883005947 active site 1146883005948 cytidylate kinase; Provisional; Region: cmk; PRK00023 1146883005949 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1146883005950 CMP-binding site; other site 1146883005951 The sites determining sugar specificity; other site 1146883005952 GTP-binding protein Der; Reviewed; Region: PRK03003 1146883005953 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1146883005954 G1 box; other site 1146883005955 GTP/Mg2+ binding site [chemical binding]; other site 1146883005956 Switch I region; other site 1146883005957 G2 box; other site 1146883005958 Switch II region; other site 1146883005959 G3 box; other site 1146883005960 G4 box; other site 1146883005961 G5 box; other site 1146883005962 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1146883005963 G1 box; other site 1146883005964 GTP/Mg2+ binding site [chemical binding]; other site 1146883005965 Switch I region; other site 1146883005966 G2 box; other site 1146883005967 G3 box; other site 1146883005968 Switch II region; other site 1146883005969 G4 box; other site 1146883005970 G5 box; other site 1146883005971 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1146883005972 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883005973 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883005974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883005975 classical (c) SDRs; Region: SDR_c; cd05233 1146883005976 NAD(P) binding site [chemical binding]; other site 1146883005977 active site 1146883005978 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883005979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883005980 non-specific DNA binding site [nucleotide binding]; other site 1146883005981 salt bridge; other site 1146883005982 sequence-specific DNA binding site [nucleotide binding]; other site 1146883005983 Cupin domain; Region: Cupin_2; pfam07883 1146883005984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883005985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883005986 TM-ABC transporter signature motif; other site 1146883005987 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883005988 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1146883005989 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1146883005990 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1146883005991 Walker A/P-loop; other site 1146883005992 ATP binding site [chemical binding]; other site 1146883005993 Q-loop/lid; other site 1146883005994 ABC transporter signature motif; other site 1146883005995 Walker B; other site 1146883005996 D-loop; other site 1146883005997 H-loop/switch region; other site 1146883005998 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1146883005999 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883006000 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883006001 TM-ABC transporter signature motif; other site 1146883006002 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883006003 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883006004 NAD(P) binding site [chemical binding]; other site 1146883006005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883006006 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1146883006007 active site 1146883006008 metal binding site [ion binding]; metal-binding site 1146883006009 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883006010 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1146883006011 NAD(P) binding site [chemical binding]; other site 1146883006012 active site 1146883006013 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883006014 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883006015 NAD(P) binding site [chemical binding]; other site 1146883006016 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883006017 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883006018 NAD(P) binding site [chemical binding]; other site 1146883006019 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1146883006020 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1146883006021 dimer interface [polypeptide binding]; other site 1146883006022 active site 1146883006023 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1146883006024 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1146883006025 active site 1146883006026 dimer interface [polypeptide binding]; other site 1146883006027 metal binding site [ion binding]; metal-binding site 1146883006028 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1146883006029 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1146883006030 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1146883006031 classical (c) SDRs; Region: SDR_c; cd05233 1146883006032 NAD(P) binding site [chemical binding]; other site 1146883006033 active site 1146883006034 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1146883006035 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1146883006036 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1146883006037 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1146883006038 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1146883006039 putative active site [active] 1146883006040 putative catalytic site [active] 1146883006041 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1146883006042 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883006043 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1146883006044 acyl-activating enzyme (AAE) consensus motif; other site 1146883006045 putative AMP binding site [chemical binding]; other site 1146883006046 putative active site [active] 1146883006047 putative CoA binding site [chemical binding]; other site 1146883006048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1146883006049 active site 1146883006050 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1146883006051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883006052 NAD(P) binding site [chemical binding]; other site 1146883006053 active site 1146883006054 MarR family; Region: MarR_2; cl17246 1146883006055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883006056 non-specific DNA binding site [nucleotide binding]; other site 1146883006057 salt bridge; other site 1146883006058 sequence-specific DNA binding site [nucleotide binding]; other site 1146883006059 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883006060 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1146883006061 dimer interface [polypeptide binding]; other site 1146883006062 active site 1146883006063 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1146883006064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883006065 acyl-activating enzyme (AAE) consensus motif; other site 1146883006066 active site 1146883006067 AMP binding site [chemical binding]; other site 1146883006068 CoA binding site [chemical binding]; other site 1146883006069 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883006070 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883006071 Walker A/P-loop; other site 1146883006072 ATP binding site [chemical binding]; other site 1146883006073 Q-loop/lid; other site 1146883006074 ABC transporter signature motif; other site 1146883006075 Walker B; other site 1146883006076 D-loop; other site 1146883006077 H-loop/switch region; other site 1146883006078 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883006079 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883006080 Walker A/P-loop; other site 1146883006081 ATP binding site [chemical binding]; other site 1146883006082 Q-loop/lid; other site 1146883006083 ABC transporter signature motif; other site 1146883006084 Walker B; other site 1146883006085 D-loop; other site 1146883006086 H-loop/switch region; other site 1146883006087 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883006088 TM-ABC transporter signature motif; other site 1146883006089 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1146883006090 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883006091 TM-ABC transporter signature motif; other site 1146883006092 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883006093 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1146883006094 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1146883006095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883006096 active site 1146883006097 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1146883006098 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1146883006099 active site 1146883006100 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1146883006101 amidohydrolase; Region: amidohydrolases; TIGR01891 1146883006102 metal binding site [ion binding]; metal-binding site 1146883006103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1146883006104 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1146883006105 substrate binding pocket [chemical binding]; other site 1146883006106 membrane-bound complex binding site; other site 1146883006107 hinge residues; other site 1146883006108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883006109 dimer interface [polypeptide binding]; other site 1146883006110 conserved gate region; other site 1146883006111 putative PBP binding loops; other site 1146883006112 ABC-ATPase subunit interface; other site 1146883006113 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1146883006114 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1146883006115 Walker A/P-loop; other site 1146883006116 ATP binding site [chemical binding]; other site 1146883006117 Q-loop/lid; other site 1146883006118 ABC transporter signature motif; other site 1146883006119 Walker B; other site 1146883006120 D-loop; other site 1146883006121 H-loop/switch region; other site 1146883006122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1146883006123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883006124 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1146883006125 dimerization interface [polypeptide binding]; other site 1146883006126 ornithine cyclodeaminase; Validated; Region: PRK07589 1146883006127 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1146883006128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883006129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883006130 active site 1146883006131 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1146883006132 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883006133 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1146883006134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883006135 NAD(P) binding site [chemical binding]; other site 1146883006136 active site 1146883006137 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1146883006138 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1146883006139 trimer interface [polypeptide binding]; other site 1146883006140 putative metal binding site [ion binding]; other site 1146883006141 Ferredoxin [Energy production and conversion]; Region: COG1146 1146883006142 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883006143 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1146883006144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883006145 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1146883006146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883006147 acyl-activating enzyme (AAE) consensus motif; other site 1146883006148 AMP binding site [chemical binding]; other site 1146883006149 active site 1146883006150 CoA binding site [chemical binding]; other site 1146883006151 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1146883006152 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 1146883006153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883006154 substrate binding site [chemical binding]; other site 1146883006155 oxyanion hole (OAH) forming residues; other site 1146883006156 trimer interface [polypeptide binding]; other site 1146883006157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883006158 substrate binding site [chemical binding]; other site 1146883006159 trimer interface [polypeptide binding]; other site 1146883006160 oxyanion hole (OAH) forming residues; other site 1146883006161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883006162 Coenzyme A binding pocket [chemical binding]; other site 1146883006163 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883006164 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883006165 Walker A/P-loop; other site 1146883006166 ATP binding site [chemical binding]; other site 1146883006167 Q-loop/lid; other site 1146883006168 ABC transporter signature motif; other site 1146883006169 Walker B; other site 1146883006170 D-loop; other site 1146883006171 H-loop/switch region; other site 1146883006172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883006173 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883006174 Walker A/P-loop; other site 1146883006175 ATP binding site [chemical binding]; other site 1146883006176 Q-loop/lid; other site 1146883006177 ABC transporter signature motif; other site 1146883006178 Walker B; other site 1146883006179 D-loop; other site 1146883006180 H-loop/switch region; other site 1146883006181 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1146883006182 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883006183 TM-ABC transporter signature motif; other site 1146883006184 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883006185 TM-ABC transporter signature motif; other site 1146883006186 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1146883006187 Type I periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; Region: PBP1_aromatic_compounds_like; cd06332 1146883006188 putative ligand binding site [chemical binding]; other site 1146883006189 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1146883006190 PaaX-like protein; Region: PaaX; pfam07848 1146883006191 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1146883006192 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1146883006193 hypothetical protein; Provisional; Region: PRK07236 1146883006194 hypothetical protein; Provisional; Region: PRK07236 1146883006195 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1146883006196 active site 1146883006197 FMN binding site [chemical binding]; other site 1146883006198 substrate binding site [chemical binding]; other site 1146883006199 homotetramer interface [polypeptide binding]; other site 1146883006200 catalytic residue [active] 1146883006201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883006202 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1146883006203 acyl-activating enzyme (AAE) consensus motif; other site 1146883006204 AMP binding site [chemical binding]; other site 1146883006205 active site 1146883006206 CoA binding site [chemical binding]; other site 1146883006207 PaaX-like protein; Region: PaaX; pfam07848 1146883006208 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1146883006209 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1146883006210 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1146883006211 homotrimer interaction site [polypeptide binding]; other site 1146883006212 putative active site [active] 1146883006213 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883006214 classical (c) SDRs; Region: SDR_c; cd05233 1146883006215 NAD(P) binding site [chemical binding]; other site 1146883006216 active site 1146883006217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883006218 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1146883006219 substrate binding site [chemical binding]; other site 1146883006220 oxyanion hole (OAH) forming residues; other site 1146883006221 trimer interface [polypeptide binding]; other site 1146883006222 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1146883006223 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1146883006224 trimer interface [polypeptide binding]; other site 1146883006225 putative metal binding site [ion binding]; other site 1146883006226 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1146883006227 putative active site [active] 1146883006228 putative catalytic site [active] 1146883006229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1146883006230 active site 1146883006231 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883006232 CoenzymeA binding site [chemical binding]; other site 1146883006233 subunit interaction site [polypeptide binding]; other site 1146883006234 PHB binding site; other site 1146883006235 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883006236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1146883006237 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883006238 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1146883006239 TM-ABC transporter signature motif; other site 1146883006240 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1146883006241 TM-ABC transporter signature motif; other site 1146883006242 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883006243 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1146883006244 Walker A/P-loop; other site 1146883006245 ATP binding site [chemical binding]; other site 1146883006246 Q-loop/lid; other site 1146883006247 ABC transporter signature motif; other site 1146883006248 Walker B; other site 1146883006249 D-loop; other site 1146883006250 H-loop/switch region; other site 1146883006251 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883006252 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1146883006253 Walker A/P-loop; other site 1146883006254 ATP binding site [chemical binding]; other site 1146883006255 Q-loop/lid; other site 1146883006256 ABC transporter signature motif; other site 1146883006257 Walker B; other site 1146883006258 D-loop; other site 1146883006259 H-loop/switch region; other site 1146883006260 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1146883006261 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1146883006262 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1146883006263 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883006264 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1146883006265 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1146883006266 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1146883006267 NAD(P) binding site [chemical binding]; other site 1146883006268 catalytic residues [active] 1146883006269 dihydropteroate synthase; Region: DHPS; TIGR01496 1146883006270 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1146883006271 substrate binding pocket [chemical binding]; other site 1146883006272 dimer interface [polypeptide binding]; other site 1146883006273 inhibitor binding site; inhibition site 1146883006274 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1146883006275 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1146883006276 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1146883006277 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1146883006278 homodimer interface [polypeptide binding]; other site 1146883006279 NADP binding site [chemical binding]; other site 1146883006280 substrate binding site [chemical binding]; other site 1146883006281 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1146883006282 FAD binding site [chemical binding]; other site 1146883006283 PAS domain; Region: PAS; smart00091 1146883006284 PAS domain S-box; Region: sensory_box; TIGR00229 1146883006285 GAF domain; Region: GAF_2; pfam13185 1146883006286 GAF domain; Region: GAF; cl17456 1146883006287 Histidine kinase; Region: HisKA_3; pfam07730 1146883006288 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1146883006289 Mg2+ binding site [ion binding]; other site 1146883006290 G-X-G motif; other site 1146883006291 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883006292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883006293 active site 1146883006294 phosphorylation site [posttranslational modification] 1146883006295 intermolecular recognition site; other site 1146883006296 dimerization interface [polypeptide binding]; other site 1146883006297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883006298 DNA binding residues [nucleotide binding] 1146883006299 dimerization interface [polypeptide binding]; other site 1146883006300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883006301 catalytic loop [active] 1146883006302 iron binding site [ion binding]; other site 1146883006303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883006304 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1146883006305 Muconolactone delta-isomerase; Region: MIase; cl01992 1146883006306 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 1146883006307 putative dimer interface [polypeptide binding]; other site 1146883006308 putative tetramer interface [polypeptide binding]; other site 1146883006309 putative active site [active] 1146883006310 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1146883006311 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1146883006312 active site 1146883006313 metal binding site [ion binding]; metal-binding site 1146883006314 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1146883006315 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1146883006316 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1146883006317 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1146883006318 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883006319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883006320 DNA-binding site [nucleotide binding]; DNA binding site 1146883006321 FCD domain; Region: FCD; pfam07729 1146883006322 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1146883006323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1146883006324 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 1146883006325 tetramer interface [polypeptide binding]; other site 1146883006326 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1146883006327 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 1146883006328 tetramer interface [polypeptide binding]; other site 1146883006329 active site 1146883006330 metal binding site [ion binding]; metal-binding site 1146883006331 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1146883006332 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1146883006333 Amidohydrolase; Region: Amidohydro_2; pfam04909 1146883006334 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1146883006335 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1146883006336 substrate binding site [chemical binding]; other site 1146883006337 THF binding site; other site 1146883006338 zinc-binding site [ion binding]; other site 1146883006339 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1146883006340 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1146883006341 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1146883006342 putative active site [active] 1146883006343 putative substrate binding site [chemical binding]; other site 1146883006344 putative cosubstrate binding site; other site 1146883006345 catalytic site [active] 1146883006346 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1146883006347 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1146883006348 G1 box; other site 1146883006349 putative GEF interaction site [polypeptide binding]; other site 1146883006350 GTP/Mg2+ binding site [chemical binding]; other site 1146883006351 elongation factor G; Reviewed; Region: PRK12740 1146883006352 Switch I region; other site 1146883006353 G2 box; other site 1146883006354 G3 box; other site 1146883006355 Switch II region; other site 1146883006356 G4 box; other site 1146883006357 G5 box; other site 1146883006358 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1146883006359 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1146883006360 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514 1146883006361 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1146883006362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1146883006363 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1146883006364 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1146883006365 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1146883006366 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1146883006367 lipoyl attachment site [posttranslational modification]; other site 1146883006368 Double zinc ribbon; Region: DZR; pfam12773 1146883006369 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1146883006370 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1146883006371 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1146883006372 phosphopeptide binding site; other site 1146883006373 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1146883006374 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883006375 DNA binding residues [nucleotide binding] 1146883006376 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1146883006377 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1146883006378 DNA binding residues [nucleotide binding] 1146883006379 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883006380 putative dimer interface [polypeptide binding]; other site 1146883006381 glycine dehydrogenase; Provisional; Region: PRK05367 1146883006382 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883006383 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883006384 catalytic residue [active] 1146883006385 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1146883006386 tetramer interface [polypeptide binding]; other site 1146883006387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883006388 catalytic residue [active] 1146883006389 pantothenate kinase; Provisional; Region: PRK05439 1146883006390 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1146883006391 ATP-binding site [chemical binding]; other site 1146883006392 CoA-binding site [chemical binding]; other site 1146883006393 Mg2+-binding site [ion binding]; other site 1146883006394 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1146883006395 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1146883006396 substrate binding site [chemical binding]; other site 1146883006397 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1146883006398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1146883006399 motif II; other site 1146883006400 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1146883006401 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1146883006402 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1146883006403 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1146883006404 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1146883006405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1146883006406 active site 1146883006407 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 1146883006408 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883006409 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1146883006410 putative active site [active] 1146883006411 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1146883006412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883006413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883006414 homodimer interface [polypeptide binding]; other site 1146883006415 catalytic residue [active] 1146883006416 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1146883006417 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1146883006418 putative active site [active] 1146883006419 catalytic site [active] 1146883006420 putative metal binding site [ion binding]; other site 1146883006421 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1146883006422 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1146883006423 putative acyl-acceptor binding pocket; other site 1146883006424 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1146883006425 thymidine kinase; Provisional; Region: PRK04296 1146883006426 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883006427 ATP binding site [chemical binding]; other site 1146883006428 Walker A motif; other site 1146883006429 Walker B motif; other site 1146883006430 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1146883006431 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1146883006432 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1146883006433 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1146883006434 putative active site [active] 1146883006435 catalytic triad [active] 1146883006436 putative dimer interface [polypeptide binding]; other site 1146883006437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883006438 active site 1146883006439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1146883006440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883006441 Coenzyme A binding pocket [chemical binding]; other site 1146883006442 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1146883006443 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1146883006444 putative acyl-acceptor binding pocket; other site 1146883006445 carboxylate-amine ligase; Provisional; Region: PRK13517 1146883006446 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1146883006447 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883006448 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1146883006449 FeS/SAM binding site; other site 1146883006450 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1146883006451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883006452 putative DNA binding site [nucleotide binding]; other site 1146883006453 putative Zn2+ binding site [ion binding]; other site 1146883006454 AsnC family; Region: AsnC_trans_reg; pfam01037 1146883006455 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1146883006456 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1146883006457 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1146883006458 active site 1146883006459 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1146883006460 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1146883006461 active site 1146883006462 metal binding site 1 [ion binding]; metal-binding site 1146883006463 putative 5' ssDNA interaction site; other site 1146883006464 metal binding site 3; metal-binding site 1146883006465 metal binding site 2 [ion binding]; metal-binding site 1146883006466 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1146883006467 putative DNA binding site [nucleotide binding]; other site 1146883006468 putative metal binding site [ion binding]; other site 1146883006469 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1146883006470 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1146883006471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883006472 ATP binding site [chemical binding]; other site 1146883006473 putative Mg++ binding site [ion binding]; other site 1146883006474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883006475 ATP-binding site [chemical binding]; other site 1146883006476 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1146883006477 diacylglycerol kinase; Reviewed; Region: PRK11914 1146883006478 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1146883006479 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1146883006480 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1146883006481 Predicted transcriptional regulator [Transcription]; Region: COG2378 1146883006482 WYL domain; Region: WYL; pfam13280 1146883006483 Predicted transcriptional regulator [Transcription]; Region: COG2378 1146883006484 WYL domain; Region: WYL; pfam13280 1146883006485 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 1146883006486 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1146883006487 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1146883006488 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1146883006489 active site 1146883006490 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1146883006491 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1146883006492 active site 1146883006493 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 1146883006494 Pup-like protein; Region: Pup; pfam05639 1146883006495 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1146883006496 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1146883006497 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883006498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883006499 proteasome ATPase; Region: pup_AAA; TIGR03689 1146883006500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883006501 Walker A motif; other site 1146883006502 ATP binding site [chemical binding]; other site 1146883006503 Walker B motif; other site 1146883006504 arginine finger; other site 1146883006505 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1146883006506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883006507 S-adenosylmethionine binding site [chemical binding]; other site 1146883006508 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1146883006509 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1146883006510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883006511 motif II; other site 1146883006512 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1146883006513 active site 1146883006514 putative catalytic site [active] 1146883006515 CopC domain; Region: CopC; pfam04234 1146883006516 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1146883006517 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1146883006518 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1146883006519 substrate binding pocket [chemical binding]; other site 1146883006520 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1146883006521 B12 binding site [chemical binding]; other site 1146883006522 cobalt ligand [ion binding]; other site 1146883006523 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1146883006524 PAC2 family; Region: PAC2; pfam09754 1146883006525 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1146883006526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1146883006527 Zn2+ binding site [ion binding]; other site 1146883006528 Mg2+ binding site [ion binding]; other site 1146883006529 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1146883006530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883006531 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1146883006532 active site 1146883006533 HIGH motif; other site 1146883006534 nucleotide binding site [chemical binding]; other site 1146883006535 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883006536 active site 1146883006537 KMSKS motif; other site 1146883006538 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1146883006539 putative tRNA binding surface [nucleotide binding]; other site 1146883006540 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1146883006541 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1146883006542 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1146883006543 active site 1146883006544 conserved hypothetical protein; Region: TIGR03843 1146883006545 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 1146883006546 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883006547 catalytic core [active] 1146883006548 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1146883006549 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883006550 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883006551 active site 1146883006552 catalytic tetrad [active] 1146883006553 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1146883006554 AAA domain; Region: AAA_30; pfam13604 1146883006555 Family description; Region: UvrD_C_2; pfam13538 1146883006556 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1146883006557 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1146883006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883006559 dimer interface [polypeptide binding]; other site 1146883006560 conserved gate region; other site 1146883006561 putative PBP binding loops; other site 1146883006562 ABC-ATPase subunit interface; other site 1146883006563 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1146883006564 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1146883006565 Walker A/P-loop; other site 1146883006566 ATP binding site [chemical binding]; other site 1146883006567 Q-loop/lid; other site 1146883006568 ABC transporter signature motif; other site 1146883006569 Walker B; other site 1146883006570 D-loop; other site 1146883006571 H-loop/switch region; other site 1146883006572 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1146883006573 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883006574 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1146883006575 NAD(P) binding site [chemical binding]; other site 1146883006576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883006577 S-adenosylmethionine binding site [chemical binding]; other site 1146883006578 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1146883006579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883006580 NAD(P) binding site [chemical binding]; other site 1146883006581 active site 1146883006582 hypothetical protein; Provisional; Region: PRK07906 1146883006583 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1146883006584 putative metal binding site [ion binding]; other site 1146883006585 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883006586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883006587 metal binding site [ion binding]; metal-binding site 1146883006588 active site 1146883006589 I-site; other site 1146883006590 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1146883006591 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1146883006592 AAA domain; Region: AAA_22; pfam13401 1146883006593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883006594 ATP binding site [chemical binding]; other site 1146883006595 putative Mg++ binding site [ion binding]; other site 1146883006596 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1146883006597 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883006598 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1146883006599 putative NAD(P) binding site [chemical binding]; other site 1146883006600 SEC-C motif; Region: SEC-C; pfam02810 1146883006601 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1146883006602 SNF2 Helicase protein; Region: DUF3670; pfam12419 1146883006603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883006604 ATP binding site [chemical binding]; other site 1146883006605 putative Mg++ binding site [ion binding]; other site 1146883006606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883006607 nucleotide binding region [chemical binding]; other site 1146883006608 ATP-binding site [chemical binding]; other site 1146883006609 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1146883006610 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1146883006611 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1146883006612 putative active site [active] 1146883006613 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883006614 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883006615 active site 1146883006616 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1146883006617 Cupin domain; Region: Cupin_2; pfam07883 1146883006618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883006619 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883006620 DNA binding residues [nucleotide binding] 1146883006621 dimerization interface [polypeptide binding]; other site 1146883006622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883006623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883006624 NAD(P) binding site [chemical binding]; other site 1146883006625 active site 1146883006626 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1146883006627 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 1146883006628 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883006629 putative catalytic site [active] 1146883006630 putative metal binding site [ion binding]; other site 1146883006631 putative phosphate binding site [ion binding]; other site 1146883006632 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1146883006633 CHAT domain; Region: CHAT; pfam12770 1146883006634 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1146883006635 structural tetrad; other site 1146883006636 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1146883006637 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1146883006638 active site 1146883006639 catalytic residues [active] 1146883006640 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1146883006641 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 1146883006642 Zn binding site [ion binding]; other site 1146883006643 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1146883006644 active site 1146883006645 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1146883006646 active site 1146883006647 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1146883006648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883006649 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883006650 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883006651 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883006652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1146883006653 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1146883006654 TAP-like protein; Region: Abhydrolase_4; pfam08386 1146883006655 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883006656 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883006657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883006658 Berberine and berberine like; Region: BBE; pfam08031 1146883006659 Predicted ATPase [General function prediction only]; Region: COG3899 1146883006660 AAA ATPase domain; Region: AAA_16; pfam13191 1146883006661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883006662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883006663 DNA binding residues [nucleotide binding] 1146883006664 dimerization interface [polypeptide binding]; other site 1146883006665 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1146883006666 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883006667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1146883006668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883006669 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1146883006670 enoyl-CoA hydratase; Provisional; Region: PRK07509 1146883006671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883006672 substrate binding site [chemical binding]; other site 1146883006673 oxyanion hole (OAH) forming residues; other site 1146883006674 trimer interface [polypeptide binding]; other site 1146883006675 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1146883006676 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1146883006677 putative active site [active] 1146883006678 catalytic site [active] 1146883006679 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1146883006680 putative active site [active] 1146883006681 catalytic site [active] 1146883006682 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1146883006683 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1146883006684 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1146883006685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883006686 dimer interface [polypeptide binding]; other site 1146883006687 conserved gate region; other site 1146883006688 ABC-ATPase subunit interface; other site 1146883006689 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1146883006690 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1146883006691 Walker A/P-loop; other site 1146883006692 ATP binding site [chemical binding]; other site 1146883006693 Q-loop/lid; other site 1146883006694 ABC transporter signature motif; other site 1146883006695 Walker B; other site 1146883006696 D-loop; other site 1146883006697 H-loop/switch region; other site 1146883006698 NIL domain; Region: NIL; cl09633 1146883006699 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1146883006700 Active_site [active] 1146883006701 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1146883006702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883006703 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1146883006704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883006705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883006706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1146883006707 putative acyl-acceptor binding pocket; other site 1146883006708 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1146883006709 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1146883006710 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1146883006711 nucleophile elbow; other site 1146883006712 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1146883006713 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1146883006714 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883006715 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1146883006716 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1146883006717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883006718 S-adenosylmethionine binding site [chemical binding]; other site 1146883006719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883006720 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1146883006721 ATP binding site [chemical binding]; other site 1146883006722 putative Mg++ binding site [ion binding]; other site 1146883006723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883006724 nucleotide binding region [chemical binding]; other site 1146883006725 ATP-binding site [chemical binding]; other site 1146883006726 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1146883006727 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1146883006728 catalytic residues [active] 1146883006729 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1146883006730 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1146883006731 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1146883006732 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883006733 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883006734 NAD(P) binding site [chemical binding]; other site 1146883006735 Fic/DOC family; Region: Fic; pfam02661 1146883006736 Histidine kinase; Region: HisKA_3; pfam07730 1146883006737 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1146883006738 Mg2+ binding site [ion binding]; other site 1146883006739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883006740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883006741 active site 1146883006742 phosphorylation site [posttranslational modification] 1146883006743 intermolecular recognition site; other site 1146883006744 dimerization interface [polypeptide binding]; other site 1146883006745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883006746 DNA binding residues [nucleotide binding] 1146883006747 dimerization interface [polypeptide binding]; other site 1146883006748 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1146883006749 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1146883006750 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1146883006751 ligand binding site [chemical binding]; other site 1146883006752 NAD binding site [chemical binding]; other site 1146883006753 tetramer interface [polypeptide binding]; other site 1146883006754 catalytic site [active] 1146883006755 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1146883006756 L-serine binding site [chemical binding]; other site 1146883006757 ACT domain interface; other site 1146883006758 hypothetical protein; Provisional; Region: PRK10621 1146883006759 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1146883006760 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1146883006761 putative active site [active] 1146883006762 putative metal binding site [ion binding]; other site 1146883006763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883006764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883006765 ATP binding site [chemical binding]; other site 1146883006766 Mg2+ binding site [ion binding]; other site 1146883006767 G-X-G motif; other site 1146883006768 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1146883006769 kynureninase; Region: kynureninase; TIGR01814 1146883006770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883006771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883006772 catalytic residue [active] 1146883006773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1146883006774 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1146883006775 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1146883006776 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1146883006777 catalytic residues [active] 1146883006778 CHASE4 domain; Region: CHASE4; cl01308 1146883006779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883006780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883006781 metal binding site [ion binding]; metal-binding site 1146883006782 active site 1146883006783 I-site; other site 1146883006784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883006785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883006786 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1146883006787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883006788 acyl-activating enzyme (AAE) consensus motif; other site 1146883006789 active site 1146883006790 AMP binding site [chemical binding]; other site 1146883006791 CoA binding site [chemical binding]; other site 1146883006792 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1146883006793 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1146883006794 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1146883006795 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1146883006796 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1146883006797 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1146883006798 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1146883006799 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1146883006800 FAD binding pocket [chemical binding]; other site 1146883006801 FAD binding motif [chemical binding]; other site 1146883006802 phosphate binding motif [ion binding]; other site 1146883006803 beta-alpha-beta structure motif; other site 1146883006804 NAD(p) ribose binding residues [chemical binding]; other site 1146883006805 NAD binding pocket [chemical binding]; other site 1146883006806 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1146883006807 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883006808 catalytic loop [active] 1146883006809 iron binding site [ion binding]; other site 1146883006810 6-phosphofructokinase; Provisional; Region: PRK03202 1146883006811 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1146883006812 active site 1146883006813 ADP/pyrophosphate binding site [chemical binding]; other site 1146883006814 dimerization interface [polypeptide binding]; other site 1146883006815 allosteric effector site; other site 1146883006816 fructose-1,6-bisphosphate binding site; other site 1146883006817 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1146883006818 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1146883006819 active site 1146883006820 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1146883006821 catalytic triad [active] 1146883006822 dimer interface [polypeptide binding]; other site 1146883006823 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1146883006824 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1146883006825 FAD binding pocket [chemical binding]; other site 1146883006826 FAD binding motif [chemical binding]; other site 1146883006827 phosphate binding motif [ion binding]; other site 1146883006828 NAD binding pocket [chemical binding]; other site 1146883006829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883006830 AMP-binding enzyme; Region: AMP-binding; pfam00501 1146883006831 acyl-activating enzyme (AAE) consensus motif; other site 1146883006832 AMP binding site [chemical binding]; other site 1146883006833 active site 1146883006834 CoA binding site [chemical binding]; other site 1146883006835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883006836 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1146883006837 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883006838 active site 1146883006839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883006840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883006841 active site 1146883006842 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1146883006843 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883006844 Walker A/P-loop; other site 1146883006845 ATP binding site [chemical binding]; other site 1146883006846 Q-loop/lid; other site 1146883006847 ABC transporter signature motif; other site 1146883006848 Walker B; other site 1146883006849 D-loop; other site 1146883006850 H-loop/switch region; other site 1146883006851 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1146883006852 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1146883006853 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1146883006854 Walker A/P-loop; other site 1146883006855 ATP binding site [chemical binding]; other site 1146883006856 Q-loop/lid; other site 1146883006857 ABC transporter signature motif; other site 1146883006858 Walker B; other site 1146883006859 D-loop; other site 1146883006860 H-loop/switch region; other site 1146883006861 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1146883006862 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1146883006863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883006864 putative PBP binding loops; other site 1146883006865 dimer interface [polypeptide binding]; other site 1146883006866 ABC-ATPase subunit interface; other site 1146883006867 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1146883006868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883006869 putative PBP binding loops; other site 1146883006870 ABC-ATPase subunit interface; other site 1146883006871 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1146883006872 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1146883006873 Predicted ATPase [General function prediction only]; Region: COG3899 1146883006874 AAA ATPase domain; Region: AAA_16; pfam13191 1146883006875 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883006876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883006877 DNA binding residues [nucleotide binding] 1146883006878 dimerization interface [polypeptide binding]; other site 1146883006879 Domain of unknown function (DUF336); Region: DUF336; cl01249 1146883006880 Patatin-like phospholipase; Region: Patatin; pfam01734 1146883006881 nucleophile elbow; other site 1146883006882 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1146883006883 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883006884 Ligand Binding Site [chemical binding]; other site 1146883006885 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883006886 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1146883006887 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1146883006888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883006889 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1146883006890 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1146883006891 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1146883006892 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1146883006893 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1146883006894 dimerization interface [polypeptide binding]; other site 1146883006895 active site 1146883006896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1146883006897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1146883006898 DNA binding site [nucleotide binding] 1146883006899 domain linker motif; other site 1146883006900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883006901 MMPL family; Region: MMPL; pfam03176 1146883006902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883006903 ATP binding site [chemical binding]; other site 1146883006904 putative Mg++ binding site [ion binding]; other site 1146883006905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883006906 nucleotide binding region [chemical binding]; other site 1146883006907 ATP-binding site [chemical binding]; other site 1146883006908 Transcription factor WhiB; Region: Whib; pfam02467 1146883006909 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883006910 Cytochrome P450; Region: p450; cl12078 1146883006911 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1146883006912 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1146883006913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883006914 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1146883006915 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1146883006916 active site 1146883006917 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1146883006918 catalytic triad [active] 1146883006919 dimer interface [polypeptide binding]; other site 1146883006920 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1146883006921 hypothetical protein; Validated; Region: PRK00029 1146883006922 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1146883006923 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1146883006924 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883006925 active site 1146883006926 ATP binding site [chemical binding]; other site 1146883006927 substrate binding site [chemical binding]; other site 1146883006928 activation loop (A-loop); other site 1146883006929 PASTA domain; Region: PASTA; smart00740 1146883006930 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1146883006931 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1146883006932 active site 1146883006933 DNA binding site [nucleotide binding] 1146883006934 catalytic site [active] 1146883006935 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883006936 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883006937 active site 1146883006938 OsmC-like protein; Region: OsmC; pfam02566 1146883006939 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1146883006940 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1146883006941 heme-binding site [chemical binding]; other site 1146883006942 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1146883006943 FAD binding pocket [chemical binding]; other site 1146883006944 FAD binding motif [chemical binding]; other site 1146883006945 phosphate binding motif [ion binding]; other site 1146883006946 beta-alpha-beta structure motif; other site 1146883006947 NAD binding pocket [chemical binding]; other site 1146883006948 Heme binding pocket [chemical binding]; other site 1146883006949 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1146883006950 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1146883006951 heme-binding site [chemical binding]; other site 1146883006952 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1146883006953 FAD binding pocket [chemical binding]; other site 1146883006954 FAD binding motif [chemical binding]; other site 1146883006955 phosphate binding motif [ion binding]; other site 1146883006956 beta-alpha-beta structure motif; other site 1146883006957 NAD binding pocket [chemical binding]; other site 1146883006958 DivIVA protein; Region: DivIVA; pfam05103 1146883006959 DivIVA domain; Region: DivI1A_domain; TIGR03544 1146883006960 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1146883006961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883006962 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1146883006963 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1146883006964 active site 1146883006965 catalytic site [active] 1146883006966 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1146883006967 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883006968 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883006969 metal binding site [ion binding]; metal-binding site 1146883006970 active site 1146883006971 I-site; other site 1146883006972 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1146883006973 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1146883006974 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1146883006975 active site 1146883006976 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1146883006977 DNA binding site [nucleotide binding] 1146883006978 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1146883006979 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1146883006980 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883006981 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883006982 GAF domain; Region: GAF; pfam01590 1146883006983 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1146883006984 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1146883006985 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883006986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883006987 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883006988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883006989 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1146883006990 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1146883006991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1146883006992 active site 1146883006993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883006994 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1146883006995 putative NAD(P) binding site [chemical binding]; other site 1146883006996 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1146883006997 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1146883006998 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 1146883006999 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1146883007000 dihydropteroate synthase; Region: DHPS; TIGR01496 1146883007001 substrate binding pocket [chemical binding]; other site 1146883007002 dimer interface [polypeptide binding]; other site 1146883007003 inhibitor binding site; inhibition site 1146883007004 DNA methylase; Region: N6_N4_Mtase; pfam01555 1146883007005 Hemerythrin-like domain; Region: Hr-like; cd12108 1146883007006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1146883007007 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1146883007008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883007009 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 1146883007010 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883007011 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1146883007012 Erythromycin esterase; Region: Erythro_esteras; cl17110 1146883007013 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1146883007014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1146883007015 active site 1146883007016 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1146883007017 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1146883007018 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1146883007019 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1146883007020 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1146883007021 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1146883007022 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1146883007023 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1146883007024 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1146883007025 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1146883007026 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1146883007027 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1146883007028 TIGR03086 family protein; Region: TIGR03086 1146883007029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883007030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883007031 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883007032 NlpC/P60 family; Region: NLPC_P60; pfam00877 1146883007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883007034 putative substrate translocation pore; other site 1146883007035 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1146883007036 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883007037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883007038 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1146883007039 Walker A/P-loop; other site 1146883007040 ATP binding site [chemical binding]; other site 1146883007041 Q-loop/lid; other site 1146883007042 ABC transporter signature motif; other site 1146883007043 Walker B; other site 1146883007044 D-loop; other site 1146883007045 H-loop/switch region; other site 1146883007046 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1146883007047 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1146883007048 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1146883007049 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1146883007050 spermidine synthase; Provisional; Region: PRK03612 1146883007051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883007052 S-adenosylmethionine binding site [chemical binding]; other site 1146883007053 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1146883007054 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1146883007055 G1 box; other site 1146883007056 putative GEF interaction site [polypeptide binding]; other site 1146883007057 GTP/Mg2+ binding site [chemical binding]; other site 1146883007058 Switch I region; other site 1146883007059 G2 box; other site 1146883007060 G3 box; other site 1146883007061 Switch II region; other site 1146883007062 G4 box; other site 1146883007063 G5 box; other site 1146883007064 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1146883007065 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1146883007066 classical (c) SDRs; Region: SDR_c; cd05233 1146883007067 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1146883007068 NAD(P) binding site [chemical binding]; other site 1146883007069 active site 1146883007070 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1146883007071 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1146883007072 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1146883007073 PYR/PP interface [polypeptide binding]; other site 1146883007074 dimer interface [polypeptide binding]; other site 1146883007075 TPP binding site [chemical binding]; other site 1146883007076 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1146883007077 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1146883007078 TPP-binding site [chemical binding]; other site 1146883007079 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1146883007080 PspC domain; Region: PspC; cl00864 1146883007081 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1146883007082 DNA-binding site [nucleotide binding]; DNA binding site 1146883007083 RNA-binding motif; other site 1146883007084 Maltose acetyltransferase; Region: Mac; pfam12464 1146883007085 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1146883007086 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1146883007087 YciI-like protein; Reviewed; Region: PRK12866 1146883007088 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1146883007089 active site 1146883007090 SUMO-1 interface [polypeptide binding]; other site 1146883007091 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883007092 catalytic core [active] 1146883007093 Phosphotransferase enzyme family; Region: APH; pfam01636 1146883007094 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1146883007095 putative active site [active] 1146883007096 putative substrate binding site [chemical binding]; other site 1146883007097 ATP binding site [chemical binding]; other site 1146883007098 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883007099 anti sigma factor interaction site; other site 1146883007100 regulatory phosphorylation site [posttranslational modification]; other site 1146883007101 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1146883007102 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1146883007103 active site 1146883007104 catalytic residues [active] 1146883007105 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1146883007106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883007107 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1146883007108 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883007109 active site 1146883007110 metal binding site [ion binding]; metal-binding site 1146883007111 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1146883007112 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1146883007113 Ion channel; Region: Ion_trans_2; pfam07885 1146883007114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883007115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883007116 active site 1146883007117 phosphorylation site [posttranslational modification] 1146883007118 intermolecular recognition site; other site 1146883007119 dimerization interface [polypeptide binding]; other site 1146883007120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883007121 DNA binding site [nucleotide binding] 1146883007122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883007123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883007124 dimer interface [polypeptide binding]; other site 1146883007125 phosphorylation site [posttranslational modification] 1146883007126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883007127 ATP binding site [chemical binding]; other site 1146883007128 Mg2+ binding site [ion binding]; other site 1146883007129 G-X-G motif; other site 1146883007130 Sporulation and spore germination; Region: Germane; pfam10646 1146883007131 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1146883007132 Predicted membrane protein [Function unknown]; Region: COG4325 1146883007133 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883007134 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1146883007135 molybdopterin cofactor binding site; other site 1146883007136 DNA polymerase II large subunit; Provisional; Region: PRK14714 1146883007137 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1146883007138 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1146883007139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883007140 active site 1146883007141 DNA binding site [nucleotide binding] 1146883007142 Int/Topo IB signature motif; other site 1146883007143 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1146883007144 [4Fe-4S] binding site [ion binding]; other site 1146883007145 molybdopterin cofactor binding site; other site 1146883007146 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883007147 anti sigma factor interaction site; other site 1146883007148 regulatory phosphorylation site [posttranslational modification]; other site 1146883007149 Protein of unknown function (DUF421); Region: DUF421; pfam04239 1146883007150 na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844 1146883007151 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1146883007152 dimerization interface [polypeptide binding]; other site 1146883007153 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1146883007154 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1146883007155 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1146883007156 active site 1146883007157 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883007158 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883007159 NAD(P) binding site [chemical binding]; other site 1146883007160 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1146883007161 active site 1146883007162 citrylCoA binding site [chemical binding]; other site 1146883007163 oxalacetate binding site [chemical binding]; other site 1146883007164 coenzyme A binding site [chemical binding]; other site 1146883007165 catalytic triad [active] 1146883007166 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883007167 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883007168 hypothetical protein; Provisional; Region: PRK08204 1146883007169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883007170 active site 1146883007171 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1146883007172 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1146883007173 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883007174 pyridoxamine kinase; Validated; Region: PRK05756 1146883007175 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1146883007176 pyridoxal binding site [chemical binding]; other site 1146883007177 dimer interface [polypeptide binding]; other site 1146883007178 ATP binding site [chemical binding]; other site 1146883007179 ribonuclease Z; Reviewed; Region: PRK00055 1146883007180 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1146883007181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883007182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883007183 ATP binding site [chemical binding]; other site 1146883007184 Mg2+ binding site [ion binding]; other site 1146883007185 G-X-G motif; other site 1146883007186 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1146883007187 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1146883007188 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1146883007189 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1146883007190 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1146883007191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883007192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883007193 putative substrate translocation pore; other site 1146883007194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1146883007195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883007196 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1146883007197 substrate binding pocket [chemical binding]; other site 1146883007198 dimerization interface [polypeptide binding]; other site 1146883007199 Putative cyclase; Region: Cyclase; pfam04199 1146883007200 hypothetical protein; Provisional; Region: PRK06847 1146883007201 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1146883007202 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1146883007203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1146883007204 active site 1146883007205 metal binding site [ion binding]; metal-binding site 1146883007206 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1146883007207 active site 1146883007208 metal binding site [ion binding]; metal-binding site 1146883007209 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883007210 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883007211 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1146883007212 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883007213 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883007214 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883007215 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1146883007216 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883007217 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1146883007218 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1146883007219 FMN-binding pocket [chemical binding]; other site 1146883007220 flavin binding motif; other site 1146883007221 phosphate binding motif [ion binding]; other site 1146883007222 beta-alpha-beta structure motif; other site 1146883007223 NAD binding pocket [chemical binding]; other site 1146883007224 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883007225 catalytic loop [active] 1146883007226 iron binding site [ion binding]; other site 1146883007227 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883007228 Cytochrome P450; Region: p450; cl12078 1146883007229 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1146883007230 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1146883007231 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1146883007232 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1146883007233 active site 1146883007234 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1146883007235 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1146883007236 active site 1146883007237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883007238 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1146883007239 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883007240 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1146883007241 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1146883007242 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1146883007243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883007244 active site 1146883007245 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1146883007246 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1146883007247 active site 1146883007248 HDOD domain; Region: HDOD; pfam08668 1146883007249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883007250 putative active site [active] 1146883007251 heme pocket [chemical binding]; other site 1146883007252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883007253 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1146883007254 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1146883007255 ligand binding site [chemical binding]; other site 1146883007256 homodimer interface [polypeptide binding]; other site 1146883007257 NAD(P) binding site [chemical binding]; other site 1146883007258 trimer interface B [polypeptide binding]; other site 1146883007259 trimer interface A [polypeptide binding]; other site 1146883007260 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1146883007261 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1146883007262 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1146883007263 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883007264 anti sigma factor interaction site; other site 1146883007265 regulatory phosphorylation site [posttranslational modification]; other site 1146883007266 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1146883007267 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1146883007268 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1146883007269 catalytic residue [active] 1146883007270 Predicted methyltransferase [General function prediction only]; Region: COG3897 1146883007271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1146883007272 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1146883007273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883007274 NAD(P) binding site [chemical binding]; other site 1146883007275 active site 1146883007276 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883007277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1146883007278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883007279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883007280 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1146883007281 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1146883007282 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1146883007283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1146883007284 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1146883007285 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1146883007286 active site 1146883007287 FMN binding site [chemical binding]; other site 1146883007288 substrate binding site [chemical binding]; other site 1146883007289 3Fe-4S cluster binding site [ion binding]; other site 1146883007290 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1146883007291 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1146883007292 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1146883007293 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1146883007294 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1146883007295 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1146883007296 N- and C-terminal domain interface [polypeptide binding]; other site 1146883007297 active site 1146883007298 catalytic site [active] 1146883007299 metal binding site [ion binding]; metal-binding site 1146883007300 carbohydrate binding site [chemical binding]; other site 1146883007301 ATP binding site [chemical binding]; other site 1146883007302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883007303 putative substrate translocation pore; other site 1146883007304 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1146883007305 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883007306 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883007307 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1146883007308 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1146883007309 active site 1146883007310 catalytic triad [active] 1146883007311 oxyanion hole [active] 1146883007312 enoyl-CoA hydratase; Provisional; Region: PRK08252 1146883007313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883007314 substrate binding site [chemical binding]; other site 1146883007315 oxyanion hole (OAH) forming residues; other site 1146883007316 trimer interface [polypeptide binding]; other site 1146883007317 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1146883007318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883007319 NAD(P) binding site [chemical binding]; other site 1146883007320 active site 1146883007321 AAA domain; Region: AAA_33; pfam13671 1146883007322 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1146883007323 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1146883007324 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1146883007325 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1146883007326 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1146883007327 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1146883007328 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883007329 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883007330 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883007331 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883007332 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1146883007333 molybdopterin cofactor binding site; other site 1146883007334 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883007335 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1146883007336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883007337 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1146883007338 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1146883007339 Low-spin heme binding site [chemical binding]; other site 1146883007340 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1146883007341 D-pathway; other site 1146883007342 Putative water exit pathway; other site 1146883007343 Binuclear center (active site) [active] 1146883007344 K-pathway; other site 1146883007345 Putative proton exit pathway; other site 1146883007346 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1146883007347 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1146883007348 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1146883007349 short chain dehydrogenase; Provisional; Region: PRK07109 1146883007350 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1146883007351 putative NAD(P) binding site [chemical binding]; other site 1146883007352 active site 1146883007353 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1146883007354 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1146883007355 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1146883007356 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1146883007357 PYR/PP interface [polypeptide binding]; other site 1146883007358 dimer interface [polypeptide binding]; other site 1146883007359 tetramer interface [polypeptide binding]; other site 1146883007360 TPP binding site [chemical binding]; other site 1146883007361 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1146883007362 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1146883007363 TPP-binding site [chemical binding]; other site 1146883007364 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883007365 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883007366 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1146883007367 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1146883007368 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1146883007369 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1146883007370 metal binding site [ion binding]; metal-binding site 1146883007371 substrate binding pocket [chemical binding]; other site 1146883007372 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1146883007373 trimer interface [polypeptide binding]; other site 1146883007374 putative Zn binding site [ion binding]; other site 1146883007375 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1146883007376 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1146883007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1146883007378 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1146883007379 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1146883007380 Walker A/P-loop; other site 1146883007381 ATP binding site [chemical binding]; other site 1146883007382 Q-loop/lid; other site 1146883007383 ABC transporter signature motif; other site 1146883007384 Walker B; other site 1146883007385 D-loop; other site 1146883007386 H-loop/switch region; other site 1146883007387 HupF/HypC family; Region: HupF_HypC; pfam01455 1146883007388 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1146883007389 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1146883007390 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1146883007391 Hemerythrin-like domain; Region: Hr-like; cd12108 1146883007392 Fe binding site [ion binding]; other site 1146883007393 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1146883007394 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 1146883007395 nickel binding site [ion binding]; other site 1146883007396 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1146883007397 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1146883007398 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1146883007399 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1146883007400 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1146883007401 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1146883007402 Cytochrome c; Region: Cytochrom_C; pfam00034 1146883007403 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1146883007404 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1146883007405 D-pathway; other site 1146883007406 Putative ubiquinol binding site [chemical binding]; other site 1146883007407 Low-spin heme (heme b) binding site [chemical binding]; other site 1146883007408 Putative water exit pathway; other site 1146883007409 Binuclear center (heme o3/CuB) [ion binding]; other site 1146883007410 K-pathway; other site 1146883007411 Putative proton exit pathway; other site 1146883007412 Cytochrome c; Region: Cytochrom_C; cl11414 1146883007413 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1146883007414 Cytochrome c; Region: Cytochrom_C; cl11414 1146883007415 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1146883007416 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1146883007417 iron-sulfur cluster [ion binding]; other site 1146883007418 [2Fe-2S] cluster binding site [ion binding]; other site 1146883007419 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1146883007420 heme bH binding site [chemical binding]; other site 1146883007421 intrachain domain interface; other site 1146883007422 heme bL binding site [chemical binding]; other site 1146883007423 interchain domain interface [polypeptide binding]; other site 1146883007424 Qo binding site; other site 1146883007425 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1146883007426 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1146883007427 TPR motif; other site 1146883007428 TPR repeat; Region: TPR_11; pfam13414 1146883007429 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1146883007430 binding surface 1146883007431 TPR motif; other site 1146883007432 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1146883007433 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1146883007434 catalytic residues [active] 1146883007435 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1146883007436 CcmE; Region: CcmE; cl00994 1146883007437 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1146883007438 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1146883007439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883007440 Walker A/P-loop; other site 1146883007441 ATP binding site [chemical binding]; other site 1146883007442 ABC transporter signature motif; other site 1146883007443 Walker B; other site 1146883007444 D-loop; other site 1146883007445 H-loop/switch region; other site 1146883007446 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1146883007447 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1146883007448 PAC2 family; Region: PAC2; pfam09754 1146883007449 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1146883007450 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1146883007451 tetramer interface [polypeptide binding]; other site 1146883007452 heme binding pocket [chemical binding]; other site 1146883007453 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1146883007454 metal binding site 2 [ion binding]; metal-binding site 1146883007455 putative DNA binding helix; other site 1146883007456 metal binding site 1 [ion binding]; metal-binding site 1146883007457 dimer interface [polypeptide binding]; other site 1146883007458 structural Zn2+ binding site [ion binding]; other site 1146883007459 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1146883007460 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1146883007461 nucleotide binding site [chemical binding]; other site 1146883007462 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1146883007463 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1146883007464 active site 1146883007465 DNA binding site [nucleotide binding] 1146883007466 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1146883007467 DNA binding site [nucleotide binding] 1146883007468 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1146883007469 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1146883007470 putative DNA binding site [nucleotide binding]; other site 1146883007471 putative homodimer interface [polypeptide binding]; other site 1146883007472 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1146883007473 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883007474 anti sigma factor interaction site; other site 1146883007475 regulatory phosphorylation site [posttranslational modification]; other site 1146883007476 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1146883007477 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1146883007478 active site 1146883007479 DNA binding site [nucleotide binding] 1146883007480 Int/Topo IB signature motif; other site 1146883007481 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883007482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883007483 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883007484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883007485 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883007486 anti sigma factor interaction site; other site 1146883007487 regulatory phosphorylation site [posttranslational modification]; other site 1146883007488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883007489 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883007490 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1146883007491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883007492 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1146883007493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883007494 DNA binding residues [nucleotide binding] 1146883007495 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1146883007496 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1146883007497 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1146883007498 argininosuccinate synthase; Validated; Region: PRK05370 1146883007499 ferrochelatase; Reviewed; Region: hemH; PRK00035 1146883007500 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1146883007501 C-terminal domain interface [polypeptide binding]; other site 1146883007502 active site 1146883007503 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1146883007504 active site 1146883007505 N-terminal domain interface [polypeptide binding]; other site 1146883007506 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1146883007507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883007508 NAD(P) binding site [chemical binding]; other site 1146883007509 active site 1146883007510 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1146883007511 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1146883007512 NAD(P) binding site [chemical binding]; other site 1146883007513 homotetramer interface [polypeptide binding]; other site 1146883007514 homodimer interface [polypeptide binding]; other site 1146883007515 active site 1146883007516 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1146883007517 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1146883007518 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1146883007519 active site 1146883007520 homotetramer interface [polypeptide binding]; other site 1146883007521 homodimer interface [polypeptide binding]; other site 1146883007522 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1146883007523 active site 1146883007524 catalytic site [active] 1146883007525 Zn binding site [ion binding]; other site 1146883007526 tetramer interface [polypeptide binding]; other site 1146883007527 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1146883007528 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1146883007529 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1146883007530 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1146883007531 TIGR00268 family protein; Region: TIGR00268 1146883007532 Ligand Binding Site [chemical binding]; other site 1146883007533 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1146883007534 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883007535 Predicted membrane protein [Function unknown]; Region: COG2860 1146883007536 UPF0126 domain; Region: UPF0126; pfam03458 1146883007537 UPF0126 domain; Region: UPF0126; pfam03458 1146883007538 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1146883007539 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883007540 phenol 2-monooxygenase; Provisional; Region: PRK08294 1146883007541 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1146883007542 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1146883007543 dimer interface [polypeptide binding]; other site 1146883007544 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883007545 Cytochrome P450; Region: p450; cl12078 1146883007546 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1146883007547 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1146883007548 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1146883007549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883007550 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883007551 active site 1146883007552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883007553 active site 1146883007554 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1146883007555 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1146883007556 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1146883007557 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1146883007558 substrate binding pocket [chemical binding]; other site 1146883007559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883007560 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1146883007561 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883007562 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1146883007563 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1146883007564 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883007565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883007566 TM-ABC transporter signature motif; other site 1146883007567 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1146883007568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883007569 Walker A/P-loop; other site 1146883007570 ATP binding site [chemical binding]; other site 1146883007571 Q-loop/lid; other site 1146883007572 ABC transporter signature motif; other site 1146883007573 Walker B; other site 1146883007574 D-loop; other site 1146883007575 H-loop/switch region; other site 1146883007576 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1146883007577 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1146883007578 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1146883007579 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1146883007580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1146883007581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1146883007582 DNA binding site [nucleotide binding] 1146883007583 domain linker motif; other site 1146883007584 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1146883007585 dimerization interface [polypeptide binding]; other site 1146883007586 ligand binding site [chemical binding]; other site 1146883007587 short chain dehydrogenase; Provisional; Region: PRK07060 1146883007588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883007589 NAD(P) binding site [chemical binding]; other site 1146883007590 active site 1146883007591 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1146883007592 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1146883007593 active site 1146883007594 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1146883007595 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1146883007596 putative ligand binding site [chemical binding]; other site 1146883007597 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883007598 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883007599 TM-ABC transporter signature motif; other site 1146883007600 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883007601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883007602 Walker A/P-loop; other site 1146883007603 ATP binding site [chemical binding]; other site 1146883007604 Q-loop/lid; other site 1146883007605 ABC transporter signature motif; other site 1146883007606 Walker B; other site 1146883007607 D-loop; other site 1146883007608 H-loop/switch region; other site 1146883007609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1146883007610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1146883007611 DNA binding site [nucleotide binding] 1146883007612 domain linker motif; other site 1146883007613 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1146883007614 dimerization interface [polypeptide binding]; other site 1146883007615 ligand binding site [chemical binding]; other site 1146883007616 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1146883007617 putative active cleft [active] 1146883007618 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1146883007619 intersubunit interface [polypeptide binding]; other site 1146883007620 active site 1146883007621 zinc binding site [ion binding]; other site 1146883007622 Na+ binding site [ion binding]; other site 1146883007623 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1146883007624 putative substrate binding site [chemical binding]; other site 1146883007625 putative ATP binding site [chemical binding]; other site 1146883007626 D-xylulose kinase; Region: XylB; TIGR01312 1146883007627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1146883007628 nucleotide binding site [chemical binding]; other site 1146883007629 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883007630 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1146883007631 Integrase core domain; Region: rve; pfam00665 1146883007632 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1146883007633 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1146883007634 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1146883007635 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1146883007636 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1146883007637 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1146883007638 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883007639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883007640 Walker A motif; other site 1146883007641 ATP binding site [chemical binding]; other site 1146883007642 Walker B motif; other site 1146883007643 arginine finger; other site 1146883007644 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1146883007645 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1146883007646 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1146883007647 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883007648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1146883007649 active site 1146883007650 phosphorylation site [posttranslational modification] 1146883007651 intermolecular recognition site; other site 1146883007652 dimerization interface [polypeptide binding]; other site 1146883007653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883007654 DNA binding residues [nucleotide binding] 1146883007655 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1146883007656 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1146883007657 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883007658 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1146883007659 putative active site [active] 1146883007660 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1146883007661 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1146883007662 G3 box; other site 1146883007663 Switch II region; other site 1146883007664 G4 box; other site 1146883007665 Beta protein; Region: Beta_protein; pfam14350 1146883007666 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1146883007667 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1146883007668 NAD(P) binding site [chemical binding]; other site 1146883007669 hypothetical protein; Provisional; Region: PRK13685 1146883007670 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1146883007671 metal ion-dependent adhesion site (MIDAS); other site 1146883007672 Protein of unknown function DUF58; Region: DUF58; pfam01882 1146883007673 MoxR-like ATPases [General function prediction only]; Region: COG0714 1146883007674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883007675 Walker A motif; other site 1146883007676 ATP binding site [chemical binding]; other site 1146883007677 Walker B motif; other site 1146883007678 arginine finger; other site 1146883007679 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883007680 NlpC/P60 family; Region: NLPC_P60; pfam00877 1146883007681 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1146883007682 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883007683 acyl-activating enzyme (AAE) consensus motif; other site 1146883007684 AMP binding site [chemical binding]; other site 1146883007685 active site 1146883007686 CoA binding site [chemical binding]; other site 1146883007687 NAD-dependent deacetylase; Provisional; Region: PRK00481 1146883007688 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1146883007689 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1146883007690 active site 1146883007691 aconitate hydratase; Provisional; Region: acnA; PRK12881 1146883007692 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1146883007693 substrate binding site [chemical binding]; other site 1146883007694 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1146883007695 ligand binding site [chemical binding]; other site 1146883007696 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1146883007697 substrate binding site [chemical binding]; other site 1146883007698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883007699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883007700 NAD(P) binding site [chemical binding]; other site 1146883007701 active site 1146883007702 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1146883007703 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1146883007704 putative active site [active] 1146883007705 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1146883007706 putative active site [active] 1146883007707 fumarylacetoacetase; Region: PLN02856 1146883007708 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1146883007709 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883007710 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1146883007711 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1146883007712 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1146883007713 dimer interface [polypeptide binding]; other site 1146883007714 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1146883007715 active site 1146883007716 Fe binding site [ion binding]; other site 1146883007717 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1146883007718 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1146883007719 putative DNA binding site [nucleotide binding]; other site 1146883007720 putative Zn2+ binding site [ion binding]; other site 1146883007721 AsnC family; Region: AsnC_trans_reg; pfam01037 1146883007722 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1146883007723 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1146883007724 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1146883007725 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1146883007726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883007727 Walker A/P-loop; other site 1146883007728 ATP binding site [chemical binding]; other site 1146883007729 Q-loop/lid; other site 1146883007730 ABC transporter signature motif; other site 1146883007731 Walker B; other site 1146883007732 D-loop; other site 1146883007733 H-loop/switch region; other site 1146883007734 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1146883007735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883007736 substrate binding site [chemical binding]; other site 1146883007737 oxyanion hole (OAH) forming residues; other site 1146883007738 trimer interface [polypeptide binding]; other site 1146883007739 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1146883007740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883007741 Walker A/P-loop; other site 1146883007742 ATP binding site [chemical binding]; other site 1146883007743 Q-loop/lid; other site 1146883007744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883007745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883007746 Dodecin; Region: Dodecin; pfam07311 1146883007747 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1146883007748 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1146883007749 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1146883007750 trimerization site [polypeptide binding]; other site 1146883007751 active site 1146883007752 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883007753 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1146883007754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883007755 catalytic residue [active] 1146883007756 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1146883007757 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1146883007758 Walker A/P-loop; other site 1146883007759 ATP binding site [chemical binding]; other site 1146883007760 Q-loop/lid; other site 1146883007761 ABC transporter signature motif; other site 1146883007762 Walker B; other site 1146883007763 D-loop; other site 1146883007764 H-loop/switch region; other site 1146883007765 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1146883007766 [2Fe-2S] cluster binding site [ion binding]; other site 1146883007767 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1146883007768 FeS assembly protein SufD; Region: sufD; TIGR01981 1146883007769 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1146883007770 FeS assembly protein SufB; Region: sufB; TIGR01980 1146883007771 Predicted transcriptional regulator [Transcription]; Region: COG2345 1146883007772 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1146883007773 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1146883007774 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1146883007775 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1146883007776 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1146883007777 UbiA prenyltransferase family; Region: UbiA; pfam01040 1146883007778 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1146883007779 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1146883007780 TPP-binding site [chemical binding]; other site 1146883007781 dimer interface [polypeptide binding]; other site 1146883007782 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1146883007783 PYR/PP interface [polypeptide binding]; other site 1146883007784 dimer interface [polypeptide binding]; other site 1146883007785 TPP binding site [chemical binding]; other site 1146883007786 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1146883007787 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1146883007788 putative active site [active] 1146883007789 transaldolase; Provisional; Region: PRK03903 1146883007790 catalytic residue [active] 1146883007791 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11489127, 4214896, 4275311; Product type e : enzyme 1146883007792 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1146883007793 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1146883007794 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1146883007795 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1146883007796 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1146883007797 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1146883007798 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1146883007799 putative active site [active] 1146883007800 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1146883007801 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1146883007802 peptide binding site [polypeptide binding]; other site 1146883007803 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1146883007804 triosephosphate isomerase; Provisional; Region: PRK14567 1146883007805 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1146883007806 substrate binding site [chemical binding]; other site 1146883007807 dimer interface [polypeptide binding]; other site 1146883007808 catalytic triad [active] 1146883007809 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1146883007810 Phosphoglycerate kinase; Region: PGK; pfam00162 1146883007811 substrate binding site [chemical binding]; other site 1146883007812 hinge regions; other site 1146883007813 ADP binding site [chemical binding]; other site 1146883007814 catalytic site [active] 1146883007815 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1146883007816 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1146883007817 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1146883007818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1146883007819 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1146883007820 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1146883007821 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1146883007822 putative substrate binding pocket [chemical binding]; other site 1146883007823 dimer interface [polypeptide binding]; other site 1146883007824 phosphate binding site [ion binding]; other site 1146883007825 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1146883007826 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1146883007827 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1146883007828 GIY-YIG motif/motif A; other site 1146883007829 active site 1146883007830 catalytic site [active] 1146883007831 putative DNA binding site [nucleotide binding]; other site 1146883007832 metal binding site [ion binding]; metal-binding site 1146883007833 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1146883007834 Helix-hairpin-helix motif; Region: HHH; pfam00633 1146883007835 helix-hairpin-helix signature motif; other site 1146883007836 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1146883007837 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1146883007838 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1146883007839 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1146883007840 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1146883007841 Amidase; Region: Amidase; cl11426 1146883007842 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883007843 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1146883007844 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1146883007845 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883007846 Integral membrane protein TerC family; Region: TerC; cl10468 1146883007847 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1146883007848 excinuclease ABC subunit B; Provisional; Region: PRK05298 1146883007849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883007850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883007851 nucleotide binding region [chemical binding]; other site 1146883007852 ATP-binding site [chemical binding]; other site 1146883007853 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1146883007854 UvrB/uvrC motif; Region: UVR; pfam02151 1146883007855 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1146883007856 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1146883007857 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1146883007858 active site 1146883007859 catalytic site [active] 1146883007860 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1146883007861 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1146883007862 active site 1146883007863 catalytic site [active] 1146883007864 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1146883007865 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1146883007866 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1146883007867 catalytic site [active] 1146883007868 active site 1146883007869 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1146883007870 RibD C-terminal domain; Region: RibD_C; cl17279 1146883007871 glycogen branching enzyme; Provisional; Region: PRK14705 1146883007872 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1146883007873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883007874 active site 1146883007875 metal binding site [ion binding]; metal-binding site 1146883007876 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1146883007877 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1146883007878 active site 1146883007879 DNA binding site [nucleotide binding] 1146883007880 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1146883007881 DNA binding site [nucleotide binding] 1146883007882 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1146883007883 TAP-like protein; Region: Abhydrolase_4; pfam08386 1146883007884 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1146883007885 nucleotide binding site [chemical binding]; other site 1146883007886 PilZ domain; Region: PilZ; pfam07238 1146883007887 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1146883007888 DNA-binding site [nucleotide binding]; DNA binding site 1146883007889 RNA-binding motif; other site 1146883007890 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1146883007891 SelR domain; Region: SelR; pfam01641 1146883007892 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1146883007893 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1146883007894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883007895 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1146883007896 substrate binding site [chemical binding]; other site 1146883007897 active site 1146883007898 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1146883007899 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1146883007900 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1146883007901 catalytic site [active] 1146883007902 putative active site [active] 1146883007903 putative substrate binding site [chemical binding]; other site 1146883007904 HRDC domain; Region: HRDC; cl02578 1146883007905 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 1146883007906 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883007907 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883007908 TM-ABC transporter signature motif; other site 1146883007909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1146883007910 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1146883007911 Walker A/P-loop; other site 1146883007912 ATP binding site [chemical binding]; other site 1146883007913 Q-loop/lid; other site 1146883007914 ABC transporter signature motif; other site 1146883007915 Walker B; other site 1146883007916 D-loop; other site 1146883007917 H-loop/switch region; other site 1146883007918 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1146883007919 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1146883007920 putative ligand binding site [chemical binding]; other site 1146883007921 Domain of unknown function DUF77; Region: DUF77; pfam01910 1146883007922 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1146883007923 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1146883007924 TPP-binding site; other site 1146883007925 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1146883007926 PYR/PP interface [polypeptide binding]; other site 1146883007927 dimer interface [polypeptide binding]; other site 1146883007928 TPP binding site [chemical binding]; other site 1146883007929 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1146883007930 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1146883007931 TRAM domain; Region: TRAM; pfam01938 1146883007932 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1146883007933 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1146883007934 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1146883007935 TrkA-N domain; Region: TrkA_N; pfam02254 1146883007936 TrkA-C domain; Region: TrkA_C; pfam02080 1146883007937 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1146883007938 TrkA-N domain; Region: TrkA_N; pfam02254 1146883007939 TrkA-C domain; Region: TrkA_C; pfam02080 1146883007940 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1146883007941 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1146883007942 generic binding surface II; other site 1146883007943 ssDNA binding site; other site 1146883007944 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1146883007945 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1146883007946 trimer interface [polypeptide binding]; other site 1146883007947 active site 1146883007948 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1146883007949 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1146883007950 Phosphotransferase enzyme family; Region: APH; pfam01636 1146883007951 putative active site [active] 1146883007952 putative substrate binding site [chemical binding]; other site 1146883007953 ATP binding site [chemical binding]; other site 1146883007954 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1146883007955 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1146883007956 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1146883007957 active site 1146883007958 dimerization interface [polypeptide binding]; other site 1146883007959 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1146883007960 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1146883007961 nucleotide binding site [chemical binding]; other site 1146883007962 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1146883007963 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1146883007964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883007965 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1146883007966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883007967 DNA binding residues [nucleotide binding] 1146883007968 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1146883007969 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1146883007970 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1146883007971 VanW like protein; Region: VanW; pfam04294 1146883007972 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1146883007973 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1146883007974 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1146883007975 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 1146883007976 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1146883007977 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1146883007978 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1146883007979 PemK-like protein; Region: PemK; pfam02452 1146883007980 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1146883007981 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1146883007982 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883007983 Berberine and berberine like; Region: BBE; pfam08031 1146883007984 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1146883007985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883007986 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1146883007987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883007988 S-adenosylmethionine binding site [chemical binding]; other site 1146883007989 OsmC-like protein; Region: OsmC; pfam02566 1146883007990 Predicted ATPase [General function prediction only]; Region: COG3899 1146883007991 AAA ATPase domain; Region: AAA_16; pfam13191 1146883007992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883007993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883007994 DNA binding residues [nucleotide binding] 1146883007995 dimerization interface [polypeptide binding]; other site 1146883007996 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1146883007997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883007998 S-adenosylmethionine binding site [chemical binding]; other site 1146883007999 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1146883008000 AAA domain; Region: AAA_22; pfam13401 1146883008001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1146883008002 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1146883008003 hydrophobic ligand binding site; other site 1146883008004 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1146883008005 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1146883008006 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1146883008007 Predicted transcriptional regulators [Transcription]; Region: COG1733 1146883008008 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1146883008009 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1146883008010 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1146883008011 putative NAD(P) binding site [chemical binding]; other site 1146883008012 active site 1146883008013 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1146883008014 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883008015 NAD binding site [chemical binding]; other site 1146883008016 catalytic Zn binding site [ion binding]; other site 1146883008017 structural Zn binding site [ion binding]; other site 1146883008018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883008019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883008020 active site 1146883008021 phosphorylation site [posttranslational modification] 1146883008022 intermolecular recognition site; other site 1146883008023 dimerization interface [polypeptide binding]; other site 1146883008024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883008025 DNA binding site [nucleotide binding] 1146883008026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883008027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1146883008028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883008029 dimer interface [polypeptide binding]; other site 1146883008030 phosphorylation site [posttranslational modification] 1146883008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883008032 ATP binding site [chemical binding]; other site 1146883008033 Mg2+ binding site [ion binding]; other site 1146883008034 G-X-G motif; other site 1146883008035 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1146883008036 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1146883008037 NodB motif; other site 1146883008038 active site 1146883008039 catalytic site [active] 1146883008040 metal binding site [ion binding]; metal-binding site 1146883008041 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883008042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883008043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1146883008044 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 1146883008045 dimerization interface [polypeptide binding]; other site 1146883008046 putative tRNAtyr binding site [nucleotide binding]; other site 1146883008047 putative active site [active] 1146883008048 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1146883008049 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1146883008050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883008051 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1146883008052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883008053 DNA binding residues [nucleotide binding] 1146883008054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1146883008055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883008056 Coenzyme A binding pocket [chemical binding]; other site 1146883008057 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1146883008058 CoA binding domain; Region: CoA_binding_2; pfam13380 1146883008059 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1146883008060 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1146883008061 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1146883008062 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1146883008063 active site 1146883008064 Zn binding site [ion binding]; other site 1146883008065 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1146883008066 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1146883008067 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1146883008068 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1146883008069 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1146883008070 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883008071 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1146883008072 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1146883008073 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1146883008074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883008075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1146883008076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883008077 S-adenosylmethionine binding site [chemical binding]; other site 1146883008078 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1146883008079 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883008080 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1146883008081 Probable Catalytic site; other site 1146883008082 metal-binding site 1146883008083 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883008084 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1146883008085 Probable Catalytic site; other site 1146883008086 metal-binding site 1146883008087 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1146883008088 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1146883008089 YibE/F-like protein; Region: YibE_F; pfam07907 1146883008090 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883008091 anti sigma factor interaction site; other site 1146883008092 regulatory phosphorylation site [posttranslational modification]; other site 1146883008093 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1146883008094 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1146883008095 putative dimer interface [polypeptide binding]; other site 1146883008096 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883008097 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1146883008098 DNA binding residues [nucleotide binding] 1146883008099 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1146883008100 putative homotetramer interface [polypeptide binding]; other site 1146883008101 putative homodimer interface [polypeptide binding]; other site 1146883008102 putative allosteric switch controlling residues; other site 1146883008103 putative metal binding site [ion binding]; other site 1146883008104 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883008105 metal-binding site [ion binding] 1146883008106 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1146883008107 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1146883008108 metal-binding site [ion binding] 1146883008109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883008110 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1146883008111 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1146883008112 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1146883008113 NAD(P) binding site [chemical binding]; other site 1146883008114 catalytic residues [active] 1146883008115 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1146883008116 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1146883008117 NADP+ binding site [chemical binding]; other site 1146883008118 folate binding site [chemical binding]; other site 1146883008119 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1146883008120 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1146883008121 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883008122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1146883008123 DNA-binding site [nucleotide binding]; DNA binding site 1146883008124 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1146883008125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1146883008126 tartrate dehydrogenase; Region: TTC; TIGR02089 1146883008127 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1146883008128 Cupin domain; Region: Cupin_2; pfam07883 1146883008129 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1146883008130 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1146883008131 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883008132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883008133 DNA-binding site [nucleotide binding]; DNA binding site 1146883008134 FCD domain; Region: FCD; pfam07729 1146883008135 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883008136 Ligand Binding Site [chemical binding]; other site 1146883008137 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1146883008138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883008139 active site 1146883008140 phosphorylation site [posttranslational modification] 1146883008141 intermolecular recognition site; other site 1146883008142 dimerization interface [polypeptide binding]; other site 1146883008143 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1146883008144 PAS domain; Region: PAS; smart00091 1146883008145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883008146 ATP binding site [chemical binding]; other site 1146883008147 Mg2+ binding site [ion binding]; other site 1146883008148 G-X-G motif; other site 1146883008149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1146883008150 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1146883008151 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1146883008152 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1146883008153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008154 NAD(P) binding site [chemical binding]; other site 1146883008155 active site 1146883008156 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1146883008157 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883008158 active site 1146883008159 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883008160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008162 active site 1146883008163 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1146883008164 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1146883008165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883008166 Walker A/P-loop; other site 1146883008167 ATP binding site [chemical binding]; other site 1146883008168 Q-loop/lid; other site 1146883008169 ABC transporter signature motif; other site 1146883008170 Walker B; other site 1146883008171 D-loop; other site 1146883008172 H-loop/switch region; other site 1146883008173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883008174 dimer interface [polypeptide binding]; other site 1146883008175 conserved gate region; other site 1146883008176 ABC-ATPase subunit interface; other site 1146883008177 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1146883008178 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1146883008179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1146883008180 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1146883008181 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1146883008182 catalytic triad [active] 1146883008183 Isochorismatase family; Region: Isochorismatase; pfam00857 1146883008184 conserved cis-peptide bond; other site 1146883008185 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1146883008186 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1146883008187 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1146883008188 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1146883008189 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1146883008190 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883008191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883008192 DNA-binding site [nucleotide binding]; DNA binding site 1146883008193 FCD domain; Region: FCD; pfam07729 1146883008194 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1146883008195 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1146883008196 tetramer interface [polypeptide binding]; other site 1146883008197 active site 1146883008198 Mg2+/Mn2+ binding site [ion binding]; other site 1146883008199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883008200 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1146883008201 substrate binding site [chemical binding]; other site 1146883008202 oxyanion hole (OAH) forming residues; other site 1146883008203 trimer interface [polypeptide binding]; other site 1146883008204 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1146883008205 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1146883008206 Part of AAA domain; Region: AAA_19; pfam13245 1146883008207 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1146883008208 AAA domain; Region: AAA_12; pfam13087 1146883008209 threonine dehydratase; Validated; Region: PRK08639 1146883008210 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1146883008211 tetramer interface [polypeptide binding]; other site 1146883008212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883008213 catalytic residue [active] 1146883008214 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1146883008215 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1146883008216 CoA binding domain; Region: CoA_binding; smart00881 1146883008217 CoA-ligase; Region: Ligase_CoA; pfam00549 1146883008218 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1146883008219 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1146883008220 CoA-ligase; Region: Ligase_CoA; pfam00549 1146883008221 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1146883008222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883008223 substrate binding site [chemical binding]; other site 1146883008224 oxyanion hole (OAH) forming residues; other site 1146883008225 trimer interface [polypeptide binding]; other site 1146883008226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1146883008227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883008228 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1146883008229 dimerization interface [polypeptide binding]; other site 1146883008230 substrate binding pocket [chemical binding]; other site 1146883008231 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1146883008232 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1146883008233 thiolase; Provisional; Region: PRK06158 1146883008234 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1146883008235 active site 1146883008236 DUF35 OB-fold domain; Region: DUF35; pfam01796 1146883008237 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1146883008238 active site 1146883008239 catalytic site [active] 1146883008240 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1146883008241 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1146883008242 active site 1146883008243 catalytic site [active] 1146883008244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008245 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883008246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008247 tricarballylate dehydrogenase; Validated; Region: PRK08274 1146883008248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883008249 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1146883008250 classical (c) SDRs; Region: SDR_c; cd05233 1146883008251 NAD(P) binding site [chemical binding]; other site 1146883008252 active site 1146883008253 acetoin reductases; Region: 23BDH; TIGR02415 1146883008254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008255 NAD(P) binding site [chemical binding]; other site 1146883008256 active site 1146883008257 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883008258 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883008259 FAD binding domain; Region: FAD_binding_2; pfam00890 1146883008260 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1146883008261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008262 putative substrate translocation pore; other site 1146883008263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883008264 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1146883008265 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1146883008266 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1146883008267 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1146883008268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883008269 substrate binding site [chemical binding]; other site 1146883008270 oxyanion hole (OAH) forming residues; other site 1146883008271 trimer interface [polypeptide binding]; other site 1146883008272 thiolase; Provisional; Region: PRK06158 1146883008273 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1146883008274 active site 1146883008275 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1146883008276 DUF35 OB-fold domain; Region: DUF35; pfam01796 1146883008277 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1146883008278 CoA binding domain; Region: CoA_binding_2; pfam13380 1146883008279 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1146883008280 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1146883008281 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1146883008282 DctM-like transporters; Region: DctM; pfam06808 1146883008283 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1146883008284 potential frameshift: common BLAST hit: gi|333991761|ref|YP_004524375.1| integrase catalytic subunit 1146883008285 Integrase core domain; Region: rve; pfam00665 1146883008286 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883008287 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883008288 Winged helix-turn helix; Region: HTH_29; pfam13551 1146883008289 Homeodomain-like domain; Region: HTH_32; pfam13565 1146883008290 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1146883008291 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1146883008292 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1146883008293 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1146883008294 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1146883008295 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1146883008296 dimerization interface [polypeptide binding]; other site 1146883008297 ligand binding site [chemical binding]; other site 1146883008298 NADP binding site [chemical binding]; other site 1146883008299 catalytic site [active] 1146883008300 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1146883008301 dimerization interface [polypeptide binding]; other site 1146883008302 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1146883008303 NAD binding site [chemical binding]; other site 1146883008304 ligand binding site [chemical binding]; other site 1146883008305 catalytic site [active] 1146883008306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883008307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883008308 active site 1146883008309 phosphorylation site [posttranslational modification] 1146883008310 intermolecular recognition site; other site 1146883008311 dimerization interface [polypeptide binding]; other site 1146883008312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883008313 DNA binding residues [nucleotide binding] 1146883008314 dimerization interface [polypeptide binding]; other site 1146883008315 Putative sensor; Region: Sensor; pfam13796 1146883008316 Histidine kinase; Region: HisKA_3; pfam07730 1146883008317 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883008318 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1146883008319 Walker A/P-loop; other site 1146883008320 ATP binding site [chemical binding]; other site 1146883008321 Q-loop/lid; other site 1146883008322 ABC transporter signature motif; other site 1146883008323 Walker B; other site 1146883008324 D-loop; other site 1146883008325 H-loop/switch region; other site 1146883008326 Hemerythrin-like domain; Region: Hr-like; cd12108 1146883008327 Fe binding site [ion binding]; other site 1146883008328 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1146883008329 [2Fe-2S] cluster binding site [ion binding]; other site 1146883008330 Transglycosylase; Region: Transgly; pfam00912 1146883008331 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1146883008332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883008333 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883008334 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1146883008335 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883008336 carboxyltransferase (CT) interaction site; other site 1146883008337 biotinylation site [posttranslational modification]; other site 1146883008338 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1146883008339 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1146883008340 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883008341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883008342 Walker A motif; other site 1146883008343 ATP binding site [chemical binding]; other site 1146883008344 arginine finger; other site 1146883008345 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1146883008346 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883008347 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883008348 active site 1146883008349 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1146883008350 Strictosidine synthase; Region: Str_synth; pfam03088 1146883008351 ERCC4 domain; Region: ERCC4; cl10594 1146883008352 Lsr2; Region: Lsr2; pfam11774 1146883008353 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1146883008354 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1146883008355 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1146883008356 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1146883008357 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1146883008358 HNH endonuclease; Region: HNH_2; pfam13391 1146883008359 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1146883008360 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883008361 Part of AAA domain; Region: AAA_19; pfam13245 1146883008362 Family description; Region: UvrD_C_2; pfam13538 1146883008363 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1146883008364 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1146883008365 active site 1146883008366 catalytic site [active] 1146883008367 substrate binding site [chemical binding]; other site 1146883008368 tellurium resistance terB-like protein; Region: terB_like; cl11965 1146883008369 metal binding site [ion binding]; metal-binding site 1146883008370 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1146883008371 Dimer interface [polypeptide binding]; other site 1146883008372 BRCT sequence motif; other site 1146883008373 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1146883008374 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1146883008375 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1146883008376 active site 1146883008377 catalytic residues [active] 1146883008378 putative catalytic site [active] 1146883008379 putative metal binding site [ion binding]; other site 1146883008380 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883008381 putative phosphate binding site [ion binding]; other site 1146883008382 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1146883008383 RNase_H superfamily; Region: RNase_H_2; pfam13482 1146883008384 AAA domain; Region: AAA_30; pfam13604 1146883008385 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1146883008386 AAA domain; Region: AAA_12; pfam13087 1146883008387 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1146883008388 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1146883008389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883008390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883008391 ATP-binding site [chemical binding]; other site 1146883008392 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1146883008393 Family description; Region: UvrD_C_2; pfam13538 1146883008394 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1146883008395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883008396 ATP binding site [chemical binding]; other site 1146883008397 putative Mg++ binding site [ion binding]; other site 1146883008398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883008399 nucleotide binding region [chemical binding]; other site 1146883008400 ATP-binding site [chemical binding]; other site 1146883008401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1146883008402 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1146883008403 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1146883008404 cofactor binding site; other site 1146883008405 DNA binding site [nucleotide binding] 1146883008406 substrate interaction site [chemical binding]; other site 1146883008407 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1146883008408 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1146883008409 mismatch recognition site; other site 1146883008410 additional DNA contacts [nucleotide binding]; other site 1146883008411 active site 1146883008412 zinc binding site [ion binding]; other site 1146883008413 DNA intercalation site [nucleotide binding]; other site 1146883008414 Restriction endonuclease NaeI; Region: NaeI; pfam09126 1146883008415 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1146883008416 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1146883008417 cofactor binding site; other site 1146883008418 DNA binding site [nucleotide binding] 1146883008419 substrate interaction site [chemical binding]; other site 1146883008420 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1146883008421 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1146883008422 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1146883008423 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1146883008424 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1146883008425 tyramine oxidase; Provisional; Region: tynA; PRK11504 1146883008426 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1146883008427 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1146883008428 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1146883008429 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1146883008430 homotetrameric interface [polypeptide binding]; other site 1146883008431 putative active site [active] 1146883008432 metal binding site [ion binding]; metal-binding site 1146883008433 SnoaL-like domain; Region: SnoaL_2; pfam12680 1146883008434 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1146883008435 ABC1 family; Region: ABC1; pfam03109 1146883008436 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1146883008437 active site 1146883008438 ATP binding site [chemical binding]; other site 1146883008439 short chain dehydrogenase; Provisional; Region: PRK06057 1146883008440 classical (c) SDRs; Region: SDR_c; cd05233 1146883008441 NAD(P) binding site [chemical binding]; other site 1146883008442 active site 1146883008443 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1146883008444 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1146883008445 NAD(P) binding site [chemical binding]; other site 1146883008446 catalytic residues [active] 1146883008447 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1146883008448 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1146883008449 conserved cys residue [active] 1146883008450 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1146883008451 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1146883008452 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1146883008453 ethanolamine permease; Region: 2A0305; TIGR00908 1146883008454 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1146883008455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883008456 DNA-binding site [nucleotide binding]; DNA binding site 1146883008457 FCD domain; Region: FCD; pfam07729 1146883008458 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1146883008459 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1146883008460 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1146883008461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883008462 motif II; other site 1146883008463 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1146883008464 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1146883008465 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1146883008466 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1146883008467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1146883008468 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1146883008469 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1146883008470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1146883008471 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1146883008472 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1146883008473 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1146883008474 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1146883008475 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1146883008476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883008477 ATP binding site [chemical binding]; other site 1146883008478 putative Mg++ binding site [ion binding]; other site 1146883008479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883008480 nucleotide binding region [chemical binding]; other site 1146883008481 ATP-binding site [chemical binding]; other site 1146883008482 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1146883008483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883008484 putative Zn2+ binding site [ion binding]; other site 1146883008485 putative DNA binding site [nucleotide binding]; other site 1146883008486 dimerization interface [polypeptide binding]; other site 1146883008487 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1146883008488 active site 1146883008489 NTP binding site [chemical binding]; other site 1146883008490 metal binding triad [ion binding]; metal-binding site 1146883008491 antibiotic binding site [chemical binding]; other site 1146883008492 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1146883008493 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1146883008494 [2Fe-2S] cluster binding site [ion binding]; other site 1146883008495 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1146883008496 putative alpha subunit interface [polypeptide binding]; other site 1146883008497 putative active site [active] 1146883008498 putative substrate binding site [chemical binding]; other site 1146883008499 Fe binding site [ion binding]; other site 1146883008500 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1146883008501 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1146883008502 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1146883008503 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1146883008504 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1146883008505 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1146883008506 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883008507 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883008508 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 1146883008509 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1146883008510 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1146883008511 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1146883008512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1146883008513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1146883008514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883008515 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1146883008516 TIGR03086 family protein; Region: TIGR03086 1146883008517 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1146883008518 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1146883008519 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1146883008520 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1146883008521 putative dimer interface [polypeptide binding]; other site 1146883008522 N-terminal domain interface [polypeptide binding]; other site 1146883008523 putative substrate binding pocket (H-site) [chemical binding]; other site 1146883008524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883008525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883008526 active site 1146883008527 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1146883008528 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1146883008529 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1146883008530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883008531 acyl-activating enzyme (AAE) consensus motif; other site 1146883008532 AMP binding site [chemical binding]; other site 1146883008533 active site 1146883008534 CoA binding site [chemical binding]; other site 1146883008535 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883008536 active site 1146883008537 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1146883008538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883008539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883008540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883008541 active site 1146883008542 enoyl-CoA hydratase; Provisional; Region: PRK05870 1146883008543 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883008544 substrate binding site [chemical binding]; other site 1146883008545 oxyanion hole (OAH) forming residues; other site 1146883008546 trimer interface [polypeptide binding]; other site 1146883008547 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1146883008548 CoA binding domain; Region: CoA_binding; cl17356 1146883008549 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1146883008550 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1146883008551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883008552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883008553 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1146883008554 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1146883008555 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883008556 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883008557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883008558 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1146883008559 putative NAD(P) binding site [chemical binding]; other site 1146883008560 putative active site [active] 1146883008561 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883008562 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883008563 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1146883008564 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1146883008565 inhibitor site; inhibition site 1146883008566 active site 1146883008567 dimer interface [polypeptide binding]; other site 1146883008568 catalytic residue [active] 1146883008569 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1146883008570 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1146883008571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883008572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008573 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1146883008574 hypothetical protein; Validated; Region: PRK06201 1146883008575 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1146883008576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883008579 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1146883008580 tartrate dehydrogenase; Region: TTC; TIGR02089 1146883008581 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1146883008582 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1146883008583 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1146883008584 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1146883008585 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883008586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883008587 DNA-binding site [nucleotide binding]; DNA binding site 1146883008588 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1146883008589 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1146883008590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008591 NAD(P) binding site [chemical binding]; other site 1146883008592 active site 1146883008593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1146883008594 putative substrate translocation pore; other site 1146883008595 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1146883008596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883008597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883008598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883008599 active site 1146883008600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883008601 PAS domain; Region: PAS_9; pfam13426 1146883008602 putative active site [active] 1146883008603 heme pocket [chemical binding]; other site 1146883008604 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1146883008605 GAF domain; Region: GAF_2; pfam13185 1146883008606 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883008607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883008608 Hemerythrin-like domain; Region: Hr-like; cd12108 1146883008609 Fe binding site [ion binding]; other site 1146883008610 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1146883008611 Part of AAA domain; Region: AAA_19; pfam13245 1146883008612 Family description; Region: UvrD_C_2; pfam13538 1146883008613 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883008614 Cytochrome P450; Region: p450; cl12078 1146883008615 SIR2-like domain; Region: SIR2_2; pfam13289 1146883008616 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1146883008617 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1146883008618 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1146883008619 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1146883008620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008621 NAD(P) binding site [chemical binding]; other site 1146883008622 active site 1146883008623 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1146883008624 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883008625 dimer interface [polypeptide binding]; other site 1146883008626 active site 1146883008627 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883008628 anti sigma factor interaction site; other site 1146883008629 regulatory phosphorylation site [posttranslational modification]; other site 1146883008630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883008631 ATP binding site [chemical binding]; other site 1146883008632 Mg2+ binding site [ion binding]; other site 1146883008633 G-X-G motif; other site 1146883008634 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1146883008635 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1146883008636 NAD(P) binding site [chemical binding]; other site 1146883008637 catalytic residues [active] 1146883008638 choline dehydrogenase; Validated; Region: PRK02106 1146883008639 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1146883008640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883008641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008642 putative substrate translocation pore; other site 1146883008643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883008644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883008645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1146883008646 ATP binding site [chemical binding]; other site 1146883008647 putative Mg++ binding site [ion binding]; other site 1146883008648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883008649 nucleotide binding region [chemical binding]; other site 1146883008650 ATP-binding site [chemical binding]; other site 1146883008651 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1146883008652 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1146883008653 Metal-binding active site; metal-binding site 1146883008654 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1146883008655 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1146883008656 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1146883008657 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1146883008658 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1146883008659 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1146883008660 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883008661 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883008662 TM-ABC transporter signature motif; other site 1146883008663 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1146883008664 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1146883008665 Walker A/P-loop; other site 1146883008666 ATP binding site [chemical binding]; other site 1146883008667 Q-loop/lid; other site 1146883008668 ABC transporter signature motif; other site 1146883008669 Walker B; other site 1146883008670 D-loop; other site 1146883008671 H-loop/switch region; other site 1146883008672 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1146883008673 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1146883008674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1146883008675 nucleotide binding site [chemical binding]; other site 1146883008676 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1146883008677 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1146883008678 xylose isomerase; Provisional; Region: PRK12677 1146883008679 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 1146883008680 MarR family; Region: MarR_2; pfam12802 1146883008681 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1146883008682 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1146883008683 nucleotide binding site [chemical binding]; other site 1146883008684 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1146883008685 D-xylulose kinase; Region: XylB; TIGR01312 1146883008686 nucleotide binding site [chemical binding]; other site 1146883008687 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883008688 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1146883008689 Integrase core domain; Region: rve; pfam00665 1146883008690 Evidence 7 : Gene remnant 1146883008691 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1146883008692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883008693 putative hydrolase; Provisional; Region: PRK11460 1146883008694 Predicted esterase [General function prediction only]; Region: COG0400 1146883008695 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1146883008696 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1146883008697 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1146883008698 oxidoreductase; Provisional; Region: PRK12743 1146883008699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883008700 NAD(P) binding site [chemical binding]; other site 1146883008701 active site 1146883008702 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1146883008703 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1146883008704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1146883008705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883008706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883008707 dimerization interface [polypeptide binding]; other site 1146883008708 putative DNA binding site [nucleotide binding]; other site 1146883008709 putative Zn2+ binding site [ion binding]; other site 1146883008710 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1146883008711 arsenical-resistance protein; Region: acr3; TIGR00832 1146883008712 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1146883008713 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1146883008714 active site 1146883008715 GXWXG protein; Region: GXWXG; pfam14231 1146883008716 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1146883008717 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1146883008718 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1146883008719 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883008720 DXD motif; other site 1146883008721 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883008722 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883008723 active site 1146883008724 catalytic tetrad [active] 1146883008725 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1146883008726 active site 1146883008727 Zn binding site [ion binding]; other site 1146883008728 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883008729 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1146883008730 dimer interface [polypeptide binding]; other site 1146883008731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883008732 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1146883008733 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1146883008734 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1146883008735 active site 1146883008736 dimer interface [polypeptide binding]; other site 1146883008737 effector binding site; other site 1146883008738 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1146883008739 TSCPD domain; Region: TSCPD; pfam12637 1146883008740 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1146883008741 ATP cone domain; Region: ATP-cone; pfam03477 1146883008742 Evidence 7 : Gene remnant 1146883008743 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1146883008744 LexA repressor; Validated; Region: PRK00215 1146883008745 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1146883008746 Catalytic site [active] 1146883008747 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1146883008748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883008749 substrate binding site [chemical binding]; other site 1146883008750 oxyanion hole (OAH) forming residues; other site 1146883008751 trimer interface [polypeptide binding]; other site 1146883008752 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1146883008753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883008754 dimer interface [polypeptide binding]; other site 1146883008755 conserved gate region; other site 1146883008756 putative PBP binding loops; other site 1146883008757 ABC-ATPase subunit interface; other site 1146883008758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1146883008759 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1146883008760 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1146883008761 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1146883008762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883008763 Walker A/P-loop; other site 1146883008764 ATP binding site [chemical binding]; other site 1146883008765 Q-loop/lid; other site 1146883008766 ABC transporter signature motif; other site 1146883008767 Walker B; other site 1146883008768 D-loop; other site 1146883008769 H-loop/switch region; other site 1146883008770 TOBE domain; Region: TOBE_2; pfam08402 1146883008771 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883008772 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883008773 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883008774 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1146883008775 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883008776 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1146883008777 active site 1146883008778 GTPases [General function prediction only]; Region: HflX; COG2262 1146883008779 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1146883008780 HflX GTPase family; Region: HflX; cd01878 1146883008781 G1 box; other site 1146883008782 GTP/Mg2+ binding site [chemical binding]; other site 1146883008783 Switch I region; other site 1146883008784 G2 box; other site 1146883008785 G3 box; other site 1146883008786 Switch II region; other site 1146883008787 G4 box; other site 1146883008788 G5 box; other site 1146883008789 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1146883008790 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1146883008791 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1146883008792 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1146883008793 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1146883008794 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1146883008795 active site 1146883008796 metal binding site [ion binding]; metal-binding site 1146883008797 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1146883008798 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1146883008799 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1146883008800 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1146883008801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1146883008802 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1146883008803 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1146883008804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883008805 FeS/SAM binding site; other site 1146883008806 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1146883008807 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1146883008808 Walker A/P-loop; other site 1146883008809 ATP binding site [chemical binding]; other site 1146883008810 Q-loop/lid; other site 1146883008811 ABC transporter signature motif; other site 1146883008812 Walker B; other site 1146883008813 D-loop; other site 1146883008814 H-loop/switch region; other site 1146883008815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1146883008816 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1146883008817 substrate binding pocket [chemical binding]; other site 1146883008818 membrane-bound complex binding site; other site 1146883008819 hinge residues; other site 1146883008820 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1146883008821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883008822 dimer interface [polypeptide binding]; other site 1146883008823 conserved gate region; other site 1146883008824 putative PBP binding loops; other site 1146883008825 ABC-ATPase subunit interface; other site 1146883008826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883008827 dimer interface [polypeptide binding]; other site 1146883008828 conserved gate region; other site 1146883008829 putative PBP binding loops; other site 1146883008830 ABC-ATPase subunit interface; other site 1146883008831 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1146883008832 recombinase A; Provisional; Region: recA; PRK09354 1146883008833 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1146883008834 hexamer interface [polypeptide binding]; other site 1146883008835 Walker A motif; other site 1146883008836 ATP binding site [chemical binding]; other site 1146883008837 Walker B motif; other site 1146883008838 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1146883008839 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1146883008840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883008841 ATP binding site [chemical binding]; other site 1146883008842 putative Mg++ binding site [ion binding]; other site 1146883008843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883008844 nucleotide binding region [chemical binding]; other site 1146883008845 ATP-binding site [chemical binding]; other site 1146883008846 DEAD/H associated; Region: DEAD_assoc; pfam08494 1146883008847 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1146883008848 putative H2TH interface [polypeptide binding]; other site 1146883008849 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1146883008850 putative DNA binding site [nucleotide binding]; other site 1146883008851 putative catalytic residues [active] 1146883008852 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1146883008853 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1146883008854 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1146883008855 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1146883008856 ATP binding site [chemical binding]; other site 1146883008857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883008858 non-specific DNA binding site [nucleotide binding]; other site 1146883008859 salt bridge; other site 1146883008860 sequence-specific DNA binding site [nucleotide binding]; other site 1146883008861 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1146883008862 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1146883008863 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1146883008864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883008865 FeS/SAM binding site; other site 1146883008866 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1146883008867 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1146883008868 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1146883008869 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1146883008870 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1146883008871 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883008872 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1146883008873 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1146883008874 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1146883008875 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1146883008876 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1146883008877 dimer interface [polypeptide binding]; other site 1146883008878 active site 1146883008879 catalytic residue [active] 1146883008880 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1146883008881 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1146883008882 folate binding site [chemical binding]; other site 1146883008883 NADP+ binding site [chemical binding]; other site 1146883008884 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1146883008885 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1146883008886 dimerization interface [polypeptide binding]; other site 1146883008887 active site 1146883008888 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1146883008889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1146883008890 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1146883008891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1146883008892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883008893 Coenzyme A binding pocket [chemical binding]; other site 1146883008894 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1146883008895 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1146883008896 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1146883008897 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1146883008898 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1146883008899 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1146883008900 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1146883008901 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1146883008902 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1146883008903 oligomer interface [polypeptide binding]; other site 1146883008904 RNA binding site [nucleotide binding]; other site 1146883008905 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1146883008906 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1146883008907 RNase E interface [polypeptide binding]; other site 1146883008908 trimer interface [polypeptide binding]; other site 1146883008909 active site 1146883008910 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1146883008911 putative nucleic acid binding region [nucleotide binding]; other site 1146883008912 G-X-X-G motif; other site 1146883008913 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1146883008914 RNA binding site [nucleotide binding]; other site 1146883008915 domain interface; other site 1146883008916 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1146883008917 16S/18S rRNA binding site [nucleotide binding]; other site 1146883008918 S13e-L30e interaction site [polypeptide binding]; other site 1146883008919 25S rRNA binding site [nucleotide binding]; other site 1146883008920 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1146883008921 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1146883008922 active site 1146883008923 Riboflavin kinase; Region: Flavokinase; pfam01687 1146883008924 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1146883008925 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1146883008926 homodimer interface [polypeptide binding]; other site 1146883008927 substrate-cofactor binding pocket; other site 1146883008928 catalytic residue [active] 1146883008929 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1146883008930 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1146883008931 AIR carboxylase; Region: AIRC; cl00310 1146883008932 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1146883008933 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1146883008934 RNA binding site [nucleotide binding]; other site 1146883008935 active site 1146883008936 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1146883008937 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1146883008938 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1146883008939 DHH family; Region: DHH; pfam01368 1146883008940 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1146883008941 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1146883008942 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1146883008943 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1146883008944 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1146883008945 G1 box; other site 1146883008946 putative GEF interaction site [polypeptide binding]; other site 1146883008947 GTP/Mg2+ binding site [chemical binding]; other site 1146883008948 Switch I region; other site 1146883008949 G2 box; other site 1146883008950 G3 box; other site 1146883008951 Switch II region; other site 1146883008952 G4 box; other site 1146883008953 G5 box; other site 1146883008954 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1146883008955 Translation-initiation factor 2; Region: IF-2; pfam11987 1146883008956 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1146883008957 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1146883008958 putative RNA binding cleft [nucleotide binding]; other site 1146883008959 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1146883008960 NusA N-terminal domain; Region: NusA_N; pfam08529 1146883008961 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1146883008962 RNA binding site [nucleotide binding]; other site 1146883008963 homodimer interface [polypeptide binding]; other site 1146883008964 NusA-like KH domain; Region: KH_5; pfam13184 1146883008965 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1146883008966 G-X-X-G motif; other site 1146883008967 Sm and related proteins; Region: Sm_like; cl00259 1146883008968 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1146883008969 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1146883008970 putative oligomer interface [polypeptide binding]; other site 1146883008971 putative RNA binding site [nucleotide binding]; other site 1146883008972 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1146883008973 dinuclear metal binding motif [ion binding]; other site 1146883008974 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1146883008975 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1146883008976 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1146883008977 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1146883008978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1146883008979 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1146883008980 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1146883008981 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1146883008982 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1146883008983 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1146883008984 active site 1146883008985 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1146883008986 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 1146883008987 putative substrate binding region [chemical binding]; other site 1146883008988 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1146883008989 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1146883008990 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1146883008991 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1146883008992 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1146883008993 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1146883008994 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1146883008995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1146883008996 FeS/SAM binding site; other site 1146883008997 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1146883008998 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1146883008999 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1146883009000 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1146883009001 [2Fe-2S] cluster binding site [ion binding]; other site 1146883009002 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1146883009003 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1146883009004 Protein of unknown function (DUF952); Region: DUF952; cl01393 1146883009005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883009006 Coenzyme A binding pocket [chemical binding]; other site 1146883009007 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1146883009008 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1146883009009 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1146883009010 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1146883009011 hinge region; other site 1146883009012 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1146883009013 putative nucleotide binding site [chemical binding]; other site 1146883009014 uridine monophosphate binding site [chemical binding]; other site 1146883009015 homohexameric interface [polypeptide binding]; other site 1146883009016 elongation factor Ts; Provisional; Region: tsf; PRK09377 1146883009017 UBA/TS-N domain; Region: UBA; pfam00627 1146883009018 Elongation factor TS; Region: EF_TS; pfam00889 1146883009019 Elongation factor TS; Region: EF_TS; pfam00889 1146883009020 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1146883009021 rRNA interaction site [nucleotide binding]; other site 1146883009022 S8 interaction site; other site 1146883009023 putative laminin-1 binding site; other site 1146883009024 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883009025 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883009026 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 1146883009027 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883009028 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1146883009029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883009030 DNA binding residues [nucleotide binding] 1146883009031 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1146883009032 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883009033 active site 1146883009034 DNA binding site [nucleotide binding] 1146883009035 Int/Topo IB signature motif; other site 1146883009036 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1146883009037 DNA protecting protein DprA; Region: dprA; TIGR00732 1146883009038 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1146883009039 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1146883009040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883009041 Walker A motif; other site 1146883009042 ATP binding site [chemical binding]; other site 1146883009043 Walker B motif; other site 1146883009044 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1146883009045 hypothetical protein; Reviewed; Region: PRK12497 1146883009046 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1146883009047 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1146883009048 RNA/DNA hybrid binding site [nucleotide binding]; other site 1146883009049 active site 1146883009050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883009051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883009052 active site 1146883009053 phosphorylation site [posttranslational modification] 1146883009054 intermolecular recognition site; other site 1146883009055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883009056 DNA binding residues [nucleotide binding] 1146883009057 dimerization interface [polypeptide binding]; other site 1146883009058 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1146883009059 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1146883009060 Catalytic site [active] 1146883009061 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1146883009062 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1146883009063 nudix motif; other site 1146883009064 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1146883009065 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1146883009066 RimM N-terminal domain; Region: RimM; pfam01782 1146883009067 PRC-barrel domain; Region: PRC; pfam05239 1146883009068 hypothetical protein; Provisional; Region: PRK02821 1146883009069 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1146883009070 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1146883009071 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1146883009072 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1146883009073 dimer interface [polypeptide binding]; other site 1146883009074 motif 1; other site 1146883009075 active site 1146883009076 motif 2; other site 1146883009077 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1146883009078 putative deacylase active site [active] 1146883009079 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1146883009080 active site 1146883009081 motif 3; other site 1146883009082 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1146883009083 anticodon binding site; other site 1146883009084 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1146883009085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883009086 active site 1146883009087 signal recognition particle protein; Provisional; Region: PRK10867 1146883009088 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1146883009089 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1146883009090 P loop; other site 1146883009091 GTP binding site [chemical binding]; other site 1146883009092 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1146883009093 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1146883009094 PII uridylyl-transferase; Provisional; Region: PRK03381 1146883009095 metal binding triad; other site 1146883009096 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1146883009097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1146883009098 Zn2+ binding site [ion binding]; other site 1146883009099 Mg2+ binding site [ion binding]; other site 1146883009100 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1146883009101 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1146883009102 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1146883009103 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1146883009104 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1146883009105 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1146883009106 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1146883009107 PDGLE domain; Region: PDGLE; pfam13190 1146883009108 Cobalt transport protein; Region: CbiQ; cl00463 1146883009109 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1146883009110 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1146883009111 Walker A/P-loop; other site 1146883009112 ATP binding site [chemical binding]; other site 1146883009113 Q-loop/lid; other site 1146883009114 ABC transporter signature motif; other site 1146883009115 Walker B; other site 1146883009116 D-loop; other site 1146883009117 H-loop/switch region; other site 1146883009118 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1146883009119 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1146883009120 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1146883009121 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1146883009122 putative active site [active] 1146883009123 putative metal binding site [ion binding]; other site 1146883009124 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1146883009125 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883009126 putative catalytic site [active] 1146883009127 putative metal binding site [ion binding]; other site 1146883009128 putative phosphate binding site [ion binding]; other site 1146883009129 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1146883009130 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883009131 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1146883009132 AAA domain; Region: AAA_23; pfam13476 1146883009133 Walker A/P-loop; other site 1146883009134 ATP binding site [chemical binding]; other site 1146883009135 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1146883009136 ABC transporter signature motif; other site 1146883009137 Walker B; other site 1146883009138 D-loop; other site 1146883009139 H-loop/switch region; other site 1146883009140 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1146883009141 Acylphosphatase; Region: Acylphosphatase; cl00551 1146883009142 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1146883009143 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1146883009144 DNA binding site [nucleotide binding] 1146883009145 catalytic residue [active] 1146883009146 H2TH interface [polypeptide binding]; other site 1146883009147 putative catalytic residues [active] 1146883009148 turnover-facilitating residue; other site 1146883009149 intercalation triad [nucleotide binding]; other site 1146883009150 8OG recognition residue [nucleotide binding]; other site 1146883009151 putative reading head residues; other site 1146883009152 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1146883009153 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1146883009154 ribonuclease III; Reviewed; Region: rnc; PRK00102 1146883009155 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1146883009156 dimerization interface [polypeptide binding]; other site 1146883009157 active site 1146883009158 metal binding site [ion binding]; metal-binding site 1146883009159 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1146883009160 dsRNA binding site [nucleotide binding]; other site 1146883009161 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1146883009162 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1146883009163 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1146883009164 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1146883009165 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1146883009166 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1146883009167 active site 1146883009168 (T/H)XGH motif; other site 1146883009169 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1146883009170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883009171 S-adenosylmethionine binding site [chemical binding]; other site 1146883009172 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1146883009173 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1146883009174 generic binding surface II; other site 1146883009175 ssDNA binding site; other site 1146883009176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883009177 ATP binding site [chemical binding]; other site 1146883009178 putative Mg++ binding site [ion binding]; other site 1146883009179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883009180 nucleotide binding region [chemical binding]; other site 1146883009181 ATP-binding site [chemical binding]; other site 1146883009182 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1146883009183 DAK2 domain; Region: Dak2; pfam02734 1146883009184 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1146883009185 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1146883009186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1146883009187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883009188 Coenzyme A binding pocket [chemical binding]; other site 1146883009189 thiamine monophosphate kinase; Provisional; Region: PRK05731 1146883009190 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1146883009191 ATP binding site [chemical binding]; other site 1146883009192 dimerization interface [polypeptide binding]; other site 1146883009193 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1146883009194 AsnC family; Region: AsnC_trans_reg; pfam01037 1146883009195 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1146883009196 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1146883009197 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1146883009198 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1146883009199 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1146883009200 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1146883009201 cystathionine gamma-lyase; Validated; Region: PRK07582 1146883009202 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883009203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883009204 catalytic residue [active] 1146883009205 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1146883009206 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1146883009207 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1146883009208 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1146883009209 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1146883009210 putative acyl-acceptor binding pocket; other site 1146883009211 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1146883009212 polyphosphate kinase; Provisional; Region: PRK05443 1146883009213 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1146883009214 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1146883009215 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1146883009216 putative domain interface [polypeptide binding]; other site 1146883009217 putative active site [active] 1146883009218 catalytic site [active] 1146883009219 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1146883009220 putative domain interface [polypeptide binding]; other site 1146883009221 putative active site [active] 1146883009222 catalytic site [active] 1146883009223 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1146883009224 active site 1146883009225 Ap6A binding site [chemical binding]; other site 1146883009226 nudix motif; other site 1146883009227 metal binding site [ion binding]; metal-binding site 1146883009228 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1146883009229 catalytic core [active] 1146883009230 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1146883009231 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1146883009232 substrate binding site [chemical binding]; other site 1146883009233 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1146883009234 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1146883009235 substrate binding site [chemical binding]; other site 1146883009236 ligand binding site [chemical binding]; other site 1146883009237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883009238 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1146883009239 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883009240 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1146883009241 Moco binding site; other site 1146883009242 metal coordination site [ion binding]; other site 1146883009243 dimerization interface [polypeptide binding]; other site 1146883009244 CAAX protease self-immunity; Region: Abi; pfam02517 1146883009245 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1146883009246 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1146883009247 HIGH motif; other site 1146883009248 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1146883009249 active site 1146883009250 KMSKS motif; other site 1146883009251 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1146883009252 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1146883009253 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1146883009254 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1146883009255 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1146883009256 catalytic triad [active] 1146883009257 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1146883009258 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1146883009259 active site 1146883009260 catalytic residues [active] 1146883009261 metal binding site [ion binding]; metal-binding site 1146883009262 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1146883009263 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1146883009264 tartrate dehydrogenase; Region: TTC; TIGR02089 1146883009265 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1146883009266 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1146883009267 ligand binding site [chemical binding]; other site 1146883009268 NAD binding site [chemical binding]; other site 1146883009269 dimerization interface [polypeptide binding]; other site 1146883009270 catalytic site [active] 1146883009271 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1146883009272 putative L-serine binding site [chemical binding]; other site 1146883009273 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1146883009274 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1146883009275 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1146883009276 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1146883009277 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1146883009278 putative valine binding site [chemical binding]; other site 1146883009279 dimer interface [polypeptide binding]; other site 1146883009280 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1146883009281 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1146883009282 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1146883009283 PYR/PP interface [polypeptide binding]; other site 1146883009284 dimer interface [polypeptide binding]; other site 1146883009285 TPP binding site [chemical binding]; other site 1146883009286 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1146883009287 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1146883009288 TPP-binding site [chemical binding]; other site 1146883009289 dimer interface [polypeptide binding]; other site 1146883009290 PAS domain S-box; Region: sensory_box; TIGR00229 1146883009291 PAS domain; Region: PAS; smart00091 1146883009292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883009293 metal binding site [ion binding]; metal-binding site 1146883009294 active site 1146883009295 I-site; other site 1146883009296 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883009297 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1146883009298 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1146883009299 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1146883009300 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1146883009301 putative ligand binding site [chemical binding]; other site 1146883009302 putative NAD binding site [chemical binding]; other site 1146883009303 catalytic site [active] 1146883009304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1146883009305 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1146883009306 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1146883009307 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1146883009308 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1146883009309 GatB domain; Region: GatB_Yqey; smart00845 1146883009310 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1146883009311 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1146883009312 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1146883009313 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1146883009314 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883009315 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1146883009316 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1146883009317 nucleotide binding pocket [chemical binding]; other site 1146883009318 K-X-D-G motif; other site 1146883009319 catalytic site [active] 1146883009320 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1146883009321 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1146883009322 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1146883009323 Dimer interface [polypeptide binding]; other site 1146883009324 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1146883009325 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1146883009326 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1146883009327 putative active site [active] 1146883009328 putative metal binding site [ion binding]; other site 1146883009329 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1146883009330 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1146883009331 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1146883009332 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1146883009333 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1146883009334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883009335 catalytic residue [active] 1146883009336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883009337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883009338 Histidine kinase; Region: HisKA_3; pfam07730 1146883009339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883009340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883009341 active site 1146883009342 phosphorylation site [posttranslational modification] 1146883009343 intermolecular recognition site; other site 1146883009344 dimerization interface [polypeptide binding]; other site 1146883009345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883009346 DNA binding residues [nucleotide binding] 1146883009347 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1146883009348 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1146883009349 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1146883009350 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1146883009351 Ligand binding site [chemical binding]; other site 1146883009352 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1146883009353 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1146883009354 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1146883009355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883009356 catalytic residue [active] 1146883009357 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1146883009358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883009359 substrate binding site [chemical binding]; other site 1146883009360 oxyanion hole (OAH) forming residues; other site 1146883009361 trimer interface [polypeptide binding]; other site 1146883009362 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1146883009363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883009364 Walker A/P-loop; other site 1146883009365 ATP binding site [chemical binding]; other site 1146883009366 Q-loop/lid; other site 1146883009367 ABC transporter signature motif; other site 1146883009368 Walker B; other site 1146883009369 D-loop; other site 1146883009370 H-loop/switch region; other site 1146883009371 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1146883009372 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1146883009373 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1146883009374 active site 1146883009375 catalytic site [active] 1146883009376 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1146883009377 phosphopeptide binding site; other site 1146883009378 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1146883009379 putative homodimer interface [polypeptide binding]; other site 1146883009380 putative active site pocket [active] 1146883009381 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1146883009382 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1146883009383 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1146883009384 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1146883009385 active site 1146883009386 homodimer interface [polypeptide binding]; other site 1146883009387 catalytic site [active] 1146883009388 acceptor binding site [chemical binding]; other site 1146883009389 trehalose synthase; Region: treS_nterm; TIGR02456 1146883009390 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1146883009391 active site 1146883009392 catalytic site [active] 1146883009393 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1146883009394 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1146883009395 glycogen branching enzyme; Provisional; Region: PRK05402 1146883009396 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1146883009397 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1146883009398 active site 1146883009399 catalytic site [active] 1146883009400 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1146883009401 Evidence 7 : Gene remnant; Product type pe : putative enzyme 1146883009402 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1146883009403 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1146883009404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883009405 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1146883009406 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1146883009407 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1146883009408 MarR family; Region: MarR; pfam01047 1146883009409 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1146883009410 putative active site [active] 1146883009411 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1146883009412 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1146883009413 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1146883009414 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1146883009415 Walker A; other site 1146883009416 putative acyltransferase; Provisional; Region: PRK05790 1146883009417 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883009418 dimer interface [polypeptide binding]; other site 1146883009419 active site 1146883009420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883009421 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1146883009422 dimer interface [polypeptide binding]; other site 1146883009423 substrate binding site [chemical binding]; other site 1146883009424 metal binding site [ion binding]; metal-binding site 1146883009425 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883009426 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1146883009427 NAD(P) binding site [chemical binding]; other site 1146883009428 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1146883009429 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1146883009430 active site 1146883009431 putative catalytic site [active] 1146883009432 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1146883009433 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1146883009434 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1146883009435 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1146883009436 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1146883009437 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1146883009438 hypothetical protein; Provisional; Region: PRK03298 1146883009439 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1146883009440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883009441 Fic family protein [Function unknown]; Region: COG3177 1146883009442 Fic/DOC family; Region: Fic; pfam02661 1146883009443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1146883009444 enoyl-CoA hydratase; Validated; Region: PRK08139 1146883009445 substrate binding site [chemical binding]; other site 1146883009446 oxyanion hole (OAH) forming residues; other site 1146883009447 trimer interface [polypeptide binding]; other site 1146883009448 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1146883009449 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1146883009450 B12 binding site [chemical binding]; other site 1146883009451 cobalt ligand [ion binding]; other site 1146883009452 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1146883009453 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1146883009454 hinge; other site 1146883009455 active site 1146883009456 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1146883009457 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1146883009458 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1146883009459 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1146883009460 gamma subunit interface [polypeptide binding]; other site 1146883009461 epsilon subunit interface [polypeptide binding]; other site 1146883009462 LBP interface [polypeptide binding]; other site 1146883009463 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1146883009464 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1146883009465 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1146883009466 alpha subunit interaction interface [polypeptide binding]; other site 1146883009467 Walker A motif; other site 1146883009468 ATP binding site [chemical binding]; other site 1146883009469 Walker B motif; other site 1146883009470 inhibitor binding site; inhibition site 1146883009471 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1146883009472 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1146883009473 core domain interface [polypeptide binding]; other site 1146883009474 delta subunit interface [polypeptide binding]; other site 1146883009475 epsilon subunit interface [polypeptide binding]; other site 1146883009476 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1146883009477 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1146883009478 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1146883009479 beta subunit interaction interface [polypeptide binding]; other site 1146883009480 Walker A motif; other site 1146883009481 ATP binding site [chemical binding]; other site 1146883009482 Walker B motif; other site 1146883009483 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1146883009484 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1146883009485 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1146883009486 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1146883009487 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1146883009488 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1146883009489 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1146883009490 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1146883009491 Mg++ binding site [ion binding]; other site 1146883009492 putative catalytic motif [active] 1146883009493 substrate binding site [chemical binding]; other site 1146883009494 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1146883009495 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1146883009496 dimer interface [polypeptide binding]; other site 1146883009497 active site 1146883009498 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1146883009499 folate binding site [chemical binding]; other site 1146883009500 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1146883009501 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1146883009502 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1146883009503 active site 1146883009504 ATP binding site [chemical binding]; other site 1146883009505 substrate binding site [chemical binding]; other site 1146883009506 activation loop (A-loop); other site 1146883009507 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1146883009508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883009509 S-adenosylmethionine binding site [chemical binding]; other site 1146883009510 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1146883009511 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1146883009512 RF-1 domain; Region: RF-1; pfam00472 1146883009513 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1146883009514 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1146883009515 transcription termination factor Rho; Provisional; Region: PRK12608 1146883009516 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1146883009517 RNA binding site [nucleotide binding]; other site 1146883009518 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1146883009519 multimer interface [polypeptide binding]; other site 1146883009520 Walker A motif; other site 1146883009521 ATP binding site [chemical binding]; other site 1146883009522 Walker B motif; other site 1146883009523 homoserine kinase; Provisional; Region: PRK01212 1146883009524 threonine synthase; Reviewed; Region: PRK06721 1146883009525 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1146883009526 homodimer interface [polypeptide binding]; other site 1146883009527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883009528 catalytic residue [active] 1146883009529 homoserine dehydrogenase; Provisional; Region: PRK06349 1146883009530 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1146883009531 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1146883009532 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1146883009533 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1146883009534 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1146883009535 active site 1146883009536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1146883009537 substrate binding site [chemical binding]; other site 1146883009538 catalytic residues [active] 1146883009539 dimer interface [polypeptide binding]; other site 1146883009540 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1146883009541 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1146883009542 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1146883009543 active site 1146883009544 HIGH motif; other site 1146883009545 KMSK motif region; other site 1146883009546 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1146883009547 tRNA binding surface [nucleotide binding]; other site 1146883009548 anticodon binding site; other site 1146883009549 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1146883009550 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1146883009551 integrase; Provisional; Region: int; PHA02601 1146883009552 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883009553 active site 1146883009554 DNA binding site [nucleotide binding] 1146883009555 Int/Topo IB signature motif; other site 1146883009556 TrwC relaxase; Region: TrwC; pfam08751 1146883009557 AAA domain; Region: AAA_30; pfam13604 1146883009558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883009559 dimerization interface [polypeptide binding]; other site 1146883009560 putative DNA binding site [nucleotide binding]; other site 1146883009561 putative Zn2+ binding site [ion binding]; other site 1146883009562 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1146883009563 dimerization interface [polypeptide binding]; other site 1146883009564 Ycf48-like protein; Provisional; Region: PRK13684 1146883009565 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1146883009566 Domain of unknown function (DUF305); Region: DUF305; cl17794 1146883009567 Evidence 7 : Gene remnant; Product type pr : putative regulator 1146883009568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883009569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883009570 PemK-like protein; Region: PemK; pfam02452 1146883009571 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1146883009572 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883009573 active site 1146883009574 catalytic residues [active] 1146883009575 DNA binding site [nucleotide binding] 1146883009576 Int/Topo IB signature motif; other site 1146883009577 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1146883009578 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883009579 active site 1146883009580 catalytic residues [active] 1146883009581 DNA binding site [nucleotide binding] 1146883009582 Int/Topo IB signature motif; other site 1146883009583 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883009584 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883009585 Aminotransferase class-V; Region: Aminotran_5; pfam00266 1146883009586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883009587 catalytic residue [active] 1146883009588 PAS domain S-box; Region: sensory_box; TIGR00229 1146883009589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883009590 putative active site [active] 1146883009591 heme pocket [chemical binding]; other site 1146883009592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883009593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883009594 metal binding site [ion binding]; metal-binding site 1146883009595 active site 1146883009596 I-site; other site 1146883009597 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883009598 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1146883009599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883009600 NAD(P) binding site [chemical binding]; other site 1146883009601 active site 1146883009602 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1146883009603 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1146883009604 acyl-activating enzyme (AAE) consensus motif; other site 1146883009605 putative AMP binding site [chemical binding]; other site 1146883009606 putative active site [active] 1146883009607 putative CoA binding site [chemical binding]; other site 1146883009608 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1146883009609 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1146883009610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1146883009611 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1146883009612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883009613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883009614 ABC transporter signature motif; other site 1146883009615 Walker B; other site 1146883009616 D-loop; other site 1146883009617 H-loop/switch region; other site 1146883009618 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1146883009619 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1146883009620 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1146883009621 cyclase homology domain; Region: CHD; cd07302 1146883009622 nucleotidyl binding site; other site 1146883009623 metal binding site [ion binding]; metal-binding site 1146883009624 dimer interface [polypeptide binding]; other site 1146883009625 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1146883009626 Ligand Binding Site [chemical binding]; other site 1146883009627 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883009628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883009629 Walker A/P-loop; other site 1146883009630 ATP binding site [chemical binding]; other site 1146883009631 Q-loop/lid; other site 1146883009632 ABC transporter signature motif; other site 1146883009633 Walker B; other site 1146883009634 D-loop; other site 1146883009635 H-loop/switch region; other site 1146883009636 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1146883009637 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1146883009638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1146883009639 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1146883009640 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1146883009641 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1146883009642 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1146883009643 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1146883009644 TPP-binding site [chemical binding]; other site 1146883009645 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1146883009646 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1146883009647 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1146883009648 hypothetical protein; Reviewed; Region: PRK09588 1146883009649 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1146883009650 MFS/sugar transport protein; Region: MFS_2; pfam13347 1146883009651 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1146883009652 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1146883009653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883009654 catalytic residue [active] 1146883009655 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1146883009656 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1146883009657 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1146883009658 putative NAD(P) binding site [chemical binding]; other site 1146883009659 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1146883009660 Catalytic site [active] 1146883009661 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 1146883009662 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883009663 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1146883009664 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1146883009665 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1146883009666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1146883009667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883009668 Coenzyme A binding pocket [chemical binding]; other site 1146883009669 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1146883009670 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1146883009671 UMP phosphatase; Provisional; Region: PRK10444 1146883009672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883009673 motif II; other site 1146883009674 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1146883009675 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1146883009676 Transcription factor WhiB; Region: Whib; pfam02467 1146883009677 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1146883009678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1146883009679 Histidine kinase; Region: HisKA_2; pfam07568 1146883009680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1146883009681 ATP binding site [chemical binding]; other site 1146883009682 Mg2+ binding site [ion binding]; other site 1146883009683 G-X-G motif; other site 1146883009684 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1146883009685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883009686 Coenzyme A binding pocket [chemical binding]; other site 1146883009687 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883009688 carboxyltransferase (CT) interaction site; other site 1146883009689 biotinylation site [posttranslational modification]; other site 1146883009690 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883009691 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1146883009692 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1146883009693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883009694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883009695 DNA binding residues [nucleotide binding] 1146883009696 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1146883009697 putative deacylase active site [active] 1146883009698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883009699 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1146883009700 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1146883009701 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1146883009702 NAD(P) binding site [chemical binding]; other site 1146883009703 catalytic residues [active] 1146883009704 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1146883009705 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1146883009706 hinge; other site 1146883009707 active site 1146883009708 Predicted GTPases [General function prediction only]; Region: COG1162 1146883009709 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1146883009710 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1146883009711 GTP/Mg2+ binding site [chemical binding]; other site 1146883009712 G4 box; other site 1146883009713 G5 box; other site 1146883009714 G1 box; other site 1146883009715 Switch I region; other site 1146883009716 G2 box; other site 1146883009717 G3 box; other site 1146883009718 Switch II region; other site 1146883009719 Homeodomain-like domain; Region: HTH_23; pfam13384 1146883009720 Winged helix-turn helix; Region: HTH_29; pfam13551 1146883009721 Homeodomain-like domain; Region: HTH_32; pfam13565 1146883009722 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1146883009723 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883009724 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883009725 active site 1146883009726 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1146883009727 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1146883009728 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1146883009729 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1146883009730 active site 1146883009731 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883009732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883009733 active site 1146883009734 catalytic tetrad [active] 1146883009735 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1146883009736 putative hydrophobic ligand binding site [chemical binding]; other site 1146883009737 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1146883009738 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1146883009739 NAD binding site [chemical binding]; other site 1146883009740 catalytic Zn binding site [ion binding]; other site 1146883009741 structural Zn binding site [ion binding]; other site 1146883009742 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1146883009743 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1146883009744 dimer interface [polypeptide binding]; other site 1146883009745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883009746 catalytic residue [active] 1146883009747 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1146883009748 cystathionine gamma-synthase; Provisional; Region: PRK07811 1146883009749 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1146883009750 homodimer interface [polypeptide binding]; other site 1146883009751 substrate-cofactor binding pocket; other site 1146883009752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883009753 catalytic residue [active] 1146883009754 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1146883009755 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1146883009756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883009757 active site 1146883009758 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1146883009759 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1146883009760 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883009761 Zn binding site [ion binding]; other site 1146883009762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883009763 Coenzyme A binding pocket [chemical binding]; other site 1146883009764 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1146883009765 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1146883009766 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883009767 Cytochrome P450; Region: p450; cl12078 1146883009768 BCCT family transporter; Region: BCCT; pfam02028 1146883009769 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1146883009770 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1146883009771 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1146883009772 hypothetical protein; Validated; Region: PRK00068 1146883009773 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1146883009774 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1146883009775 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1146883009776 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1146883009777 Protein of unknown function DUF45; Region: DUF45; cl00636 1146883009778 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1146883009779 ATP binding site [chemical binding]; other site 1146883009780 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1146883009781 ABC1 family; Region: ABC1; pfam03109 1146883009782 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1146883009783 active site 1146883009784 ATP binding site [chemical binding]; other site 1146883009785 Transcription factor WhiB; Region: Whib; pfam02467 1146883009786 potential frameshift: common BLAST hit: gi|336180326|ref|YP_004585701.1| transposase 1146883009787 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1146883009788 Winged helix-turn helix; Region: HTH_29; pfam13551 1146883009789 Homeodomain-like domain; Region: HTH_32; pfam13565 1146883009790 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1146883009791 Part of AAA domain; Region: AAA_19; pfam13245 1146883009792 Family description; Region: UvrD_C_2; pfam13538 1146883009793 HRDC domain; Region: HRDC; pfam00570 1146883009794 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1146883009795 catalytic residues [active] 1146883009796 ANTAR domain; Region: ANTAR; pfam03861 1146883009797 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1146883009798 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1146883009799 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1146883009800 putative NADH binding site [chemical binding]; other site 1146883009801 putative active site [active] 1146883009802 nudix motif; other site 1146883009803 putative metal binding site [ion binding]; other site 1146883009804 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1146883009805 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1146883009806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1146883009807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1146883009808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1146883009809 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1146883009810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883009811 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1146883009812 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1146883009813 hypothetical protein; Provisional; Region: PRK07907 1146883009814 metal binding site [ion binding]; metal-binding site 1146883009815 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1146883009816 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883009817 active site 1146883009818 metal binding site [ion binding]; metal-binding site 1146883009819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883009820 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883009821 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883009822 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1146883009823 active site 1146883009824 Part of AAA domain; Region: AAA_19; pfam13245 1146883009825 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1146883009826 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cd01594 1146883009827 tetramer interface [polypeptide binding]; other site 1146883009828 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1146883009829 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1146883009830 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1146883009831 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1146883009832 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1146883009833 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1146883009834 active site 1146883009835 DNA binding site [nucleotide binding] 1146883009836 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1146883009837 TIGR03086 family protein; Region: TIGR03086 1146883009838 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1146883009839 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1146883009840 ATP binding site [chemical binding]; other site 1146883009841 substrate interface [chemical binding]; other site 1146883009842 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1146883009843 active site residue [active] 1146883009844 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1146883009845 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883009846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883009847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883009848 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1146883009849 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1146883009850 dinuclear metal binding motif [ion binding]; other site 1146883009851 helicase 45; Provisional; Region: PTZ00424 1146883009852 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1146883009853 ATP binding site [chemical binding]; other site 1146883009854 Mg++ binding site [ion binding]; other site 1146883009855 motif III; other site 1146883009856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883009857 nucleotide binding region [chemical binding]; other site 1146883009858 ATP-binding site [chemical binding]; other site 1146883009859 PQQ-like domain; Region: PQQ_2; pfam13360 1146883009860 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883009861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883009862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883009863 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1146883009864 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1146883009865 dimer interface [polypeptide binding]; other site 1146883009866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883009867 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1146883009868 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1146883009869 active site 1146883009870 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1146883009871 Bacterial PH domain; Region: DUF304; cl01348 1146883009872 Bacterial PH domain; Region: DUF304; pfam03703 1146883009873 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1146883009874 nudix motif; other site 1146883009875 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1146883009876 putative active site [active] 1146883009877 putative catalytic site [active] 1146883009878 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1146883009879 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1146883009880 AAA domain; Region: AAA_31; pfam13614 1146883009881 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883009882 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1146883009883 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1146883009884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883009885 ATP binding site [chemical binding]; other site 1146883009886 putative Mg++ binding site [ion binding]; other site 1146883009887 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1146883009888 SEC-C motif; Region: SEC-C; pfam02810 1146883009889 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1146883009890 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1146883009891 30S subunit binding site; other site 1146883009892 lipoprotein LpqB; Provisional; Region: PRK13613 1146883009893 Sporulation and spore germination; Region: Germane; pfam10646 1146883009894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883009895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883009896 dimerization interface [polypeptide binding]; other site 1146883009897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883009898 dimer interface [polypeptide binding]; other site 1146883009899 phosphorylation site [posttranslational modification] 1146883009900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883009901 ATP binding site [chemical binding]; other site 1146883009902 Mg2+ binding site [ion binding]; other site 1146883009903 G-X-G motif; other site 1146883009904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883009905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883009906 active site 1146883009907 phosphorylation site [posttranslational modification] 1146883009908 intermolecular recognition site; other site 1146883009909 dimerization interface [polypeptide binding]; other site 1146883009910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883009911 DNA binding site [nucleotide binding] 1146883009912 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1146883009913 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1146883009914 homotetramer interface [polypeptide binding]; other site 1146883009915 ligand binding site [chemical binding]; other site 1146883009916 catalytic site [active] 1146883009917 NAD binding site [chemical binding]; other site 1146883009918 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1146883009919 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1146883009920 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1146883009921 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1146883009922 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1146883009923 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1146883009924 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1146883009925 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1146883009926 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1146883009927 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1146883009928 active site 1146883009929 substrate binding site [chemical binding]; other site 1146883009930 metal binding site [ion binding]; metal-binding site 1146883009931 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1146883009932 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1146883009933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883009934 active site 1146883009935 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1146883009936 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1146883009937 NAD binding site [chemical binding]; other site 1146883009938 substrate binding site [chemical binding]; other site 1146883009939 homodimer interface [polypeptide binding]; other site 1146883009940 active site 1146883009941 Transcription factor WhiB; Region: Whib; pfam02467 1146883009942 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1146883009943 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1146883009944 phosphate binding site [ion binding]; other site 1146883009945 dimer interface [polypeptide binding]; other site 1146883009946 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 1146883009947 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1146883009948 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1146883009949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883009950 UDP-galactopyranose mutase; Region: GLF; pfam03275 1146883009951 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1146883009952 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1146883009953 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1146883009954 helix-hairpin-helix signature motif; other site 1146883009955 active site 1146883009956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883009957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883009958 NAD(P) binding site [chemical binding]; other site 1146883009959 active site 1146883009960 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1146883009961 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1146883009962 Substrate binding site; other site 1146883009963 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883009964 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1146883009965 Probable Catalytic site; other site 1146883009966 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883009967 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1146883009968 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883009969 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1146883009970 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1146883009971 substrate binding site; other site 1146883009972 tetramer interface; other site 1146883009973 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1146883009974 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1146883009975 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1146883009976 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1146883009977 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1146883009978 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1146883009979 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1146883009980 Putative Catalytic site; other site 1146883009981 DXD motif; other site 1146883009982 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1146883009983 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1146883009984 TIGR03089 family protein; Region: TIGR03089 1146883009985 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883009986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883009987 active site 1146883009988 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1146883009989 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1146883009990 ATP-grasp domain; Region: ATP-grasp; pfam02222 1146883009991 Predicted membrane protein [Function unknown]; Region: COG2246 1146883009992 GtrA-like protein; Region: GtrA; pfam04138 1146883009993 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1146883009994 Ligand binding site; other site 1146883009995 Putative Catalytic site; other site 1146883009996 DXD motif; other site 1146883009997 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1146883009998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883009999 Walker A/P-loop; other site 1146883010000 ATP binding site [chemical binding]; other site 1146883010001 Q-loop/lid; other site 1146883010002 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1146883010003 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1146883010004 ABC transporter signature motif; other site 1146883010005 Walker B; other site 1146883010006 D-loop; other site 1146883010007 H-loop/switch region; other site 1146883010008 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1146883010009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883010010 active site 1146883010011 metal binding site [ion binding]; metal-binding site 1146883010012 DNA binding site [nucleotide binding] 1146883010013 Bacterial PH domain; Region: DUF304; pfam03703 1146883010014 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1146883010015 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1146883010016 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1146883010017 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1146883010018 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1146883010019 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1146883010020 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1146883010021 putative active site [active] 1146883010022 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1146883010023 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883010024 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1146883010025 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1146883010026 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883010027 carboxyltransferase (CT) interaction site; other site 1146883010028 biotinylation site [posttranslational modification]; other site 1146883010029 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1146883010030 amidase catalytic site [active] 1146883010031 Zn binding residues [ion binding]; other site 1146883010032 substrate binding site [chemical binding]; other site 1146883010033 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1146883010034 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1146883010035 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1146883010036 Walker A/P-loop; other site 1146883010037 ATP binding site [chemical binding]; other site 1146883010038 Q-loop/lid; other site 1146883010039 ABC transporter signature motif; other site 1146883010040 Walker B; other site 1146883010041 D-loop; other site 1146883010042 H-loop/switch region; other site 1146883010043 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1146883010044 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1146883010045 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883010046 active site 1146883010047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1146883010048 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1146883010049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883010050 S-adenosylmethionine binding site [chemical binding]; other site 1146883010051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1146883010052 active site 1146883010053 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1146883010054 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1146883010055 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1146883010056 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1146883010057 active site 1146883010058 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1146883010059 active site 1146883010060 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1146883010061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883010062 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1146883010063 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1146883010064 putative active site pocket [active] 1146883010065 dimerization interface [polypeptide binding]; other site 1146883010066 putative catalytic residue [active] 1146883010067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1146883010068 active site 1146883010069 nucleotide binding site [chemical binding]; other site 1146883010070 HIGH motif; other site 1146883010071 KMSKS motif; other site 1146883010072 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1146883010073 putative active site pocket [active] 1146883010074 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1146883010075 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1146883010076 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1146883010077 Walker A; other site 1146883010078 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1146883010079 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1146883010080 active site 1146883010081 substrate binding site [chemical binding]; other site 1146883010082 coenzyme B12 binding site [chemical binding]; other site 1146883010083 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1146883010084 B12 binding site [chemical binding]; other site 1146883010085 cobalt ligand [ion binding]; other site 1146883010086 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1146883010087 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1146883010088 heterodimer interface [polypeptide binding]; other site 1146883010089 substrate interaction site [chemical binding]; other site 1146883010090 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1146883010091 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1146883010092 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1146883010093 metal binding site [ion binding]; metal-binding site 1146883010094 putative dimer interface [polypeptide binding]; other site 1146883010095 carboxylate-amine ligase; Provisional; Region: PRK13517 1146883010096 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1146883010097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1146883010098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1146883010099 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1146883010100 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1146883010101 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1146883010102 active site 1146883010103 substrate binding site [chemical binding]; other site 1146883010104 metal binding site [ion binding]; metal-binding site 1146883010105 Protein of unknown function DUF86; Region: DUF86; pfam01934 1146883010106 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1146883010107 active site 1146883010108 NTP binding site [chemical binding]; other site 1146883010109 metal binding triad [ion binding]; metal-binding site 1146883010110 antibiotic binding site [chemical binding]; other site 1146883010111 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1146883010112 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1146883010113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1146883010114 active site 1146883010115 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1146883010116 intersubunit interface [polypeptide binding]; other site 1146883010117 active site 1146883010118 catalytic residue [active] 1146883010119 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 1146883010120 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1146883010121 NAD(P) binding site [chemical binding]; other site 1146883010122 catalytic residues [active] 1146883010123 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1146883010124 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1146883010125 NAD(P) binding site [chemical binding]; other site 1146883010126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1146883010127 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1146883010128 ATP binding site [chemical binding]; other site 1146883010129 putative Mg++ binding site [ion binding]; other site 1146883010130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883010131 nucleotide binding region [chemical binding]; other site 1146883010132 ATP-binding site [chemical binding]; other site 1146883010133 adenosine deaminase; Provisional; Region: PRK09358 1146883010134 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1146883010135 active site 1146883010136 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1146883010137 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1146883010138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1146883010139 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1146883010140 Walker A/P-loop; other site 1146883010141 ATP binding site [chemical binding]; other site 1146883010142 Q-loop/lid; other site 1146883010143 ABC transporter signature motif; other site 1146883010144 Walker B; other site 1146883010145 D-loop; other site 1146883010146 H-loop/switch region; other site 1146883010147 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1146883010148 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1146883010149 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1146883010150 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1146883010151 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1146883010152 active site 1146883010153 catalytic motif [active] 1146883010154 Zn binding site [ion binding]; other site 1146883010155 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1146883010156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883010157 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1146883010158 TM-ABC transporter signature motif; other site 1146883010159 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883010160 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1146883010161 TM-ABC transporter signature motif; other site 1146883010162 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1146883010163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883010164 Walker A/P-loop; other site 1146883010165 ATP binding site [chemical binding]; other site 1146883010166 Q-loop/lid; other site 1146883010167 ABC transporter signature motif; other site 1146883010168 Walker B; other site 1146883010169 D-loop; other site 1146883010170 H-loop/switch region; other site 1146883010171 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1146883010172 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1146883010173 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1146883010174 ligand binding site [chemical binding]; other site 1146883010175 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1146883010176 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1146883010177 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1146883010178 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1146883010179 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1146883010180 active site 1146883010181 HIGH motif; other site 1146883010182 dimer interface [polypeptide binding]; other site 1146883010183 KMSKS motif; other site 1146883010184 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1146883010185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883010186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883010187 homodimer interface [polypeptide binding]; other site 1146883010188 catalytic residue [active] 1146883010189 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1146883010190 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1146883010191 NAD binding site [chemical binding]; other site 1146883010192 homodimer interface [polypeptide binding]; other site 1146883010193 active site 1146883010194 substrate binding site [chemical binding]; other site 1146883010195 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1146883010196 Domain of unknown function DUF21; Region: DUF21; pfam01595 1146883010197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1146883010198 Transporter associated domain; Region: CorC_HlyC; smart01091 1146883010199 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1146883010200 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1146883010201 isocitrate dehydrogenase; Validated; Region: PRK08299 1146883010202 malate dehydrogenase; Reviewed; Region: PRK06223 1146883010203 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1146883010204 NAD(P) binding site [chemical binding]; other site 1146883010205 dimer interface [polypeptide binding]; other site 1146883010206 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1146883010207 substrate binding site [chemical binding]; other site 1146883010208 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1146883010209 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1146883010210 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882 1146883010211 NAD(P) binding pocket [chemical binding]; other site 1146883010212 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1146883010213 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1146883010214 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1146883010215 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1146883010216 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1146883010217 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1146883010218 purine monophosphate binding site [chemical binding]; other site 1146883010219 dimer interface [polypeptide binding]; other site 1146883010220 putative catalytic residues [active] 1146883010221 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1146883010222 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1146883010223 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1146883010224 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1146883010225 active site 1146883010226 cosubstrate binding site; other site 1146883010227 substrate binding site [chemical binding]; other site 1146883010228 catalytic site [active] 1146883010229 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1146883010230 CoA binding domain; Region: CoA_binding; smart00881 1146883010231 CoA-ligase; Region: Ligase_CoA; pfam00549 1146883010232 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1146883010233 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1146883010234 CoA-ligase; Region: Ligase_CoA; pfam00549 1146883010235 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1146883010236 B12 binding site [chemical binding]; other site 1146883010237 cobalt ligand [ion binding]; other site 1146883010238 Lipase (class 2); Region: Lipase_2; pfam01674 1146883010239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883010240 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883010241 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883010242 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1146883010243 Part of AAA domain; Region: AAA_19; pfam13245 1146883010244 Family description; Region: UvrD_C_2; pfam13538 1146883010245 Chorismate mutase type II; Region: CM_2; cl00693 1146883010246 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1146883010247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883010248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883010249 active site 1146883010250 phosphorylation site [posttranslational modification] 1146883010251 intermolecular recognition site; other site 1146883010252 dimerization interface [polypeptide binding]; other site 1146883010253 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883010254 DNA binding residues [nucleotide binding] 1146883010255 dimerization interface [polypeptide binding]; other site 1146883010256 PspC domain; Region: PspC; pfam04024 1146883010257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883010258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883010259 ATP binding site [chemical binding]; other site 1146883010260 Mg2+ binding site [ion binding]; other site 1146883010261 G-X-G motif; other site 1146883010262 PspC domain; Region: PspC; pfam04024 1146883010263 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1146883010264 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1146883010265 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1146883010266 META domain; Region: META; pfam03724 1146883010267 META domain; Region: META; pfam03724 1146883010268 META domain; Region: META; pfam03724 1146883010269 META domain; Region: META; pfam03724 1146883010270 GMP synthase; Reviewed; Region: guaA; PRK00074 1146883010271 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1146883010272 AMP/PPi binding site [chemical binding]; other site 1146883010273 candidate oxyanion hole; other site 1146883010274 catalytic triad [active] 1146883010275 potential glutamine specificity residues [chemical binding]; other site 1146883010276 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1146883010277 ATP Binding subdomain [chemical binding]; other site 1146883010278 Ligand Binding sites [chemical binding]; other site 1146883010279 Dimerization subdomain; other site 1146883010280 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1146883010281 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883010282 phosphate binding site [ion binding]; other site 1146883010283 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1146883010284 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883010285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1146883010286 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1146883010287 active site 1146883010288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883010289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883010290 active site 1146883010291 phosphorylation site [posttranslational modification] 1146883010292 intermolecular recognition site; other site 1146883010293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883010294 DNA binding residues [nucleotide binding] 1146883010295 dimerization interface [polypeptide binding]; other site 1146883010296 Transcription factor WhiB; Region: Whib; pfam02467 1146883010297 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1146883010298 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1146883010299 ring oligomerisation interface [polypeptide binding]; other site 1146883010300 ATP/Mg binding site [chemical binding]; other site 1146883010301 stacking interactions; other site 1146883010302 hinge regions; other site 1146883010303 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1146883010304 oligomerisation interface [polypeptide binding]; other site 1146883010305 mobile loop; other site 1146883010306 roof hairpin; other site 1146883010307 UGMP family protein; Validated; Region: PRK09604 1146883010308 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1146883010309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883010310 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1146883010311 Glycoprotease family; Region: Peptidase_M22; pfam00814 1146883010312 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1146883010313 putative active site [active] 1146883010314 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1146883010315 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1146883010316 Fe-S cluster binding site [ion binding]; other site 1146883010317 active site 1146883010318 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883010319 PGAP1-like protein; Region: PGAP1; pfam07819 1146883010320 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1146883010321 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1146883010322 alanine racemase; Reviewed; Region: alr; PRK00053 1146883010323 active site 1146883010324 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1146883010325 dimer interface [polypeptide binding]; other site 1146883010326 substrate binding site [chemical binding]; other site 1146883010327 catalytic residues [active] 1146883010328 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1146883010329 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1146883010330 putative substrate binding site [chemical binding]; other site 1146883010331 putative ATP binding site [chemical binding]; other site 1146883010332 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1146883010333 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1146883010334 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1146883010335 glutaminase active site [active] 1146883010336 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1146883010337 dimer interface [polypeptide binding]; other site 1146883010338 active site 1146883010339 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1146883010340 dimer interface [polypeptide binding]; other site 1146883010341 active site 1146883010342 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1146883010343 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1146883010344 active site 1146883010345 substrate binding site [chemical binding]; other site 1146883010346 metal binding site [ion binding]; metal-binding site 1146883010347 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1146883010348 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1146883010349 23S rRNA interface [nucleotide binding]; other site 1146883010350 L3 interface [polypeptide binding]; other site 1146883010351 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1146883010352 active site clefts [active] 1146883010353 zinc binding site [ion binding]; other site 1146883010354 dimer interface [polypeptide binding]; other site 1146883010355 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1146883010356 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1146883010357 substrate binding site [chemical binding]; other site 1146883010358 ATP binding site [chemical binding]; other site 1146883010359 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1146883010360 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1146883010361 dimer interface [polypeptide binding]; other site 1146883010362 putative functional site; other site 1146883010363 putative MPT binding site; other site 1146883010364 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1146883010365 trimer interface [polypeptide binding]; other site 1146883010366 dimer interface [polypeptide binding]; other site 1146883010367 putative active site [active] 1146883010368 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1146883010369 MPT binding site; other site 1146883010370 trimer interface [polypeptide binding]; other site 1146883010371 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1146883010372 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1146883010373 GTP binding site; other site 1146883010374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883010375 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1146883010376 NAD(P) binding site [chemical binding]; other site 1146883010377 active site 1146883010378 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1146883010379 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1146883010380 dimerization interface 3.5A [polypeptide binding]; other site 1146883010381 active site 1146883010382 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1146883010383 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1146883010384 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1146883010385 alphaNTD homodimer interface [polypeptide binding]; other site 1146883010386 alphaNTD - beta interaction site [polypeptide binding]; other site 1146883010387 alphaNTD - beta' interaction site [polypeptide binding]; other site 1146883010388 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1146883010389 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1146883010390 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1146883010391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1146883010392 RNA binding surface [nucleotide binding]; other site 1146883010393 30S ribosomal protein S11; Validated; Region: PRK05309 1146883010394 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1146883010395 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1146883010396 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1146883010397 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1146883010398 rRNA binding site [nucleotide binding]; other site 1146883010399 predicted 30S ribosome binding site; other site 1146883010400 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1146883010401 active site 1146883010402 adenylate kinase; Reviewed; Region: adk; PRK00279 1146883010403 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1146883010404 AMP-binding site [chemical binding]; other site 1146883010405 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1146883010406 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1146883010407 SecY translocase; Region: SecY; pfam00344 1146883010408 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1146883010409 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1146883010410 23S rRNA binding site [nucleotide binding]; other site 1146883010411 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1146883010412 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1146883010413 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1146883010414 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1146883010415 5S rRNA interface [nucleotide binding]; other site 1146883010416 23S rRNA interface [nucleotide binding]; other site 1146883010417 L5 interface [polypeptide binding]; other site 1146883010418 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1146883010419 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1146883010420 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1146883010421 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1146883010422 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1146883010423 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1146883010424 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1146883010425 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1146883010426 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1146883010427 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1146883010428 RNA binding site [nucleotide binding]; other site 1146883010429 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1146883010430 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1146883010431 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1146883010432 putative translocon interaction site; other site 1146883010433 23S rRNA interface [nucleotide binding]; other site 1146883010434 signal recognition particle (SRP54) interaction site; other site 1146883010435 L23 interface [polypeptide binding]; other site 1146883010436 trigger factor interaction site; other site 1146883010437 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1146883010438 23S rRNA interface [nucleotide binding]; other site 1146883010439 5S rRNA interface [nucleotide binding]; other site 1146883010440 putative antibiotic binding site [chemical binding]; other site 1146883010441 L25 interface [polypeptide binding]; other site 1146883010442 L27 interface [polypeptide binding]; other site 1146883010443 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1146883010444 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1146883010445 G-X-X-G motif; other site 1146883010446 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1146883010447 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1146883010448 putative translocon binding site; other site 1146883010449 protein-rRNA interface [nucleotide binding]; other site 1146883010450 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1146883010451 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1146883010452 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1146883010453 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1146883010454 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1146883010455 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1146883010456 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1146883010457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1146883010458 elongation factor Tu; Reviewed; Region: PRK00049 1146883010459 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1146883010460 G1 box; other site 1146883010461 GEF interaction site [polypeptide binding]; other site 1146883010462 GTP/Mg2+ binding site [chemical binding]; other site 1146883010463 Switch I region; other site 1146883010464 G2 box; other site 1146883010465 G3 box; other site 1146883010466 Switch II region; other site 1146883010467 G4 box; other site 1146883010468 G5 box; other site 1146883010469 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1146883010470 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1146883010471 Antibiotic Binding Site [chemical binding]; other site 1146883010472 elongation factor G; Reviewed; Region: PRK00007 1146883010473 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1146883010474 G1 box; other site 1146883010475 putative GEF interaction site [polypeptide binding]; other site 1146883010476 GTP/Mg2+ binding site [chemical binding]; other site 1146883010477 Switch I region; other site 1146883010478 G2 box; other site 1146883010479 G3 box; other site 1146883010480 Switch II region; other site 1146883010481 G4 box; other site 1146883010482 G5 box; other site 1146883010483 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1146883010484 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1146883010485 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1146883010486 30S ribosomal protein S7; Validated; Region: PRK05302 1146883010487 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1146883010488 S17 interaction site [polypeptide binding]; other site 1146883010489 S8 interaction site; other site 1146883010490 16S rRNA interaction site [nucleotide binding]; other site 1146883010491 streptomycin interaction site [chemical binding]; other site 1146883010492 23S rRNA interaction site [nucleotide binding]; other site 1146883010493 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1146883010494 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1146883010495 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1146883010496 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1146883010497 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1146883010498 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1146883010499 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1146883010500 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1146883010501 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1146883010502 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1146883010503 G-loop; other site 1146883010504 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1146883010505 DNA binding site [nucleotide binding] 1146883010506 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1146883010507 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1146883010508 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1146883010509 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1146883010510 RPB1 interaction site [polypeptide binding]; other site 1146883010511 RPB10 interaction site [polypeptide binding]; other site 1146883010512 RPB11 interaction site [polypeptide binding]; other site 1146883010513 RPB3 interaction site [polypeptide binding]; other site 1146883010514 RPB12 interaction site [polypeptide binding]; other site 1146883010515 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1146883010516 mce related protein; Region: MCE; pfam02470 1146883010517 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1146883010518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1146883010519 mce related protein; Region: MCE; pfam02470 1146883010520 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1146883010521 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1146883010522 mce related protein; Region: MCE; pfam02470 1146883010523 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1146883010524 mce related protein; Region: MCE; pfam02470 1146883010525 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1146883010526 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1146883010527 mce related protein; Region: MCE; pfam02470 1146883010528 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1146883010529 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1146883010530 Permease; Region: Permease; pfam02405 1146883010531 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1146883010532 Permease; Region: Permease; pfam02405 1146883010533 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1146883010534 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1146883010535 Walker A/P-loop; other site 1146883010536 ATP binding site [chemical binding]; other site 1146883010537 Q-loop/lid; other site 1146883010538 ABC transporter signature motif; other site 1146883010539 Walker B; other site 1146883010540 D-loop; other site 1146883010541 H-loop/switch region; other site 1146883010542 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1146883010543 peripheral dimer interface [polypeptide binding]; other site 1146883010544 core dimer interface [polypeptide binding]; other site 1146883010545 L10 interface [polypeptide binding]; other site 1146883010546 L11 interface [polypeptide binding]; other site 1146883010547 putative EF-Tu interaction site [polypeptide binding]; other site 1146883010548 putative EF-G interaction site [polypeptide binding]; other site 1146883010549 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1146883010550 23S rRNA interface [nucleotide binding]; other site 1146883010551 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1146883010552 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1146883010553 mRNA/rRNA interface [nucleotide binding]; other site 1146883010554 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1146883010555 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1146883010556 23S rRNA interface [nucleotide binding]; other site 1146883010557 L7/L12 interface [polypeptide binding]; other site 1146883010558 putative thiostrepton binding site; other site 1146883010559 L25 interface [polypeptide binding]; other site 1146883010560 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1146883010561 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1146883010562 putative homodimer interface [polypeptide binding]; other site 1146883010563 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1146883010564 heterodimer interface [polypeptide binding]; other site 1146883010565 homodimer interface [polypeptide binding]; other site 1146883010566 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1146883010567 aspartate aminotransferase; Provisional; Region: PRK05764 1146883010568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883010569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883010570 homodimer interface [polypeptide binding]; other site 1146883010571 catalytic residue [active] 1146883010572 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1146883010573 Zn binding site [ion binding]; other site 1146883010574 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1146883010575 active site 1146883010576 catalytic site [active] 1146883010577 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1146883010578 active site 1146883010579 catalytic site [active] 1146883010580 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1146883010581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883010582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883010583 metal binding site [ion binding]; metal-binding site 1146883010584 active site 1146883010585 I-site; other site 1146883010586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883010587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1146883010588 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1146883010589 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883010590 active site 1146883010591 DNA binding site [nucleotide binding] 1146883010592 Int/Topo IB signature motif; other site 1146883010593 AAA domain; Region: AAA_30; pfam13604 1146883010594 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883010595 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1146883010596 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883010597 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1146883010598 DctM-like transporters; Region: DctM; pfam06808 1146883010599 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1146883010600 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1146883010601 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1146883010602 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1146883010603 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1146883010604 Class I aldolases; Region: Aldolase_Class_I; cl17187 1146883010605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1146883010606 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1146883010607 B12 binding site [chemical binding]; other site 1146883010608 cobalt ligand [ion binding]; other site 1146883010609 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1146883010610 acyl-CoA synthetase; Validated; Region: PRK06188 1146883010611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883010612 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1146883010613 acyl-activating enzyme (AAE) consensus motif; other site 1146883010614 acyl-activating enzyme (AAE) consensus motif; other site 1146883010615 putative AMP binding site [chemical binding]; other site 1146883010616 putative active site [active] 1146883010617 putative CoA binding site [chemical binding]; other site 1146883010618 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1146883010619 DUF35 OB-fold domain; Region: DUF35; pfam01796 1146883010620 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1146883010621 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1146883010622 active site 1146883010623 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1146883010624 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1146883010625 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883010626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883010627 Coenzyme A binding pocket [chemical binding]; other site 1146883010628 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883010629 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883010630 AMP binding site [chemical binding]; other site 1146883010631 active site 1146883010632 acyl-activating enzyme (AAE) consensus motif; other site 1146883010633 CoA binding site [chemical binding]; other site 1146883010634 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1146883010635 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1146883010636 dimer interface [polypeptide binding]; other site 1146883010637 active site 1146883010638 MOSC domain; Region: MOSC; pfam03473 1146883010639 Cobalt transport protein; Region: CbiQ; cl00463 1146883010640 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1146883010641 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1146883010642 Walker A/P-loop; other site 1146883010643 ATP binding site [chemical binding]; other site 1146883010644 Q-loop/lid; other site 1146883010645 ABC transporter signature motif; other site 1146883010646 Walker B; other site 1146883010647 D-loop; other site 1146883010648 H-loop/switch region; other site 1146883010649 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1146883010650 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883010651 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883010652 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1146883010653 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1146883010654 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1146883010655 carboxyltransferase (CT) interaction site; other site 1146883010656 biotinylation site [posttranslational modification]; other site 1146883010657 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1146883010658 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1146883010659 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883010660 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1146883010661 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1146883010662 CoA binding domain; Region: CoA_binding_2; pfam13380 1146883010663 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1146883010664 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1146883010665 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1146883010666 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1146883010667 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1146883010668 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1146883010669 DctM-like transporters; Region: DctM; pfam06808 1146883010670 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1146883010671 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1146883010672 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1146883010673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1146883010674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883010675 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1146883010676 putative dimerization interface [polypeptide binding]; other site 1146883010677 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1146883010678 putative active site [active] 1146883010679 putative CoA binding site [chemical binding]; other site 1146883010680 nudix motif; other site 1146883010681 metal binding site [ion binding]; metal-binding site 1146883010682 potential frameshift: common BLAST hit: gi|375129137|ref|YP_004991232.1| Integrase catalytic region 1146883010683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1146883010684 potential frameshift: common BLAST hit: gi|182440771|ref|YP_001828490.1| transposase 1146883010685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1146883010686 Integrase core domain; Region: rve; pfam00665 1146883010687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883010688 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883010689 Walker A motif; other site 1146883010690 ATP binding site [chemical binding]; other site 1146883010691 Walker B motif; other site 1146883010692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1146883010693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883010694 dimer interface [polypeptide binding]; other site 1146883010695 conserved gate region; other site 1146883010696 putative PBP binding loops; other site 1146883010697 ABC-ATPase subunit interface; other site 1146883010698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883010699 D-loop; other site 1146883010700 H-loop/switch region; other site 1146883010701 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1146883010702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883010703 Walker A/P-loop; other site 1146883010704 ATP binding site [chemical binding]; other site 1146883010705 Q-loop/lid; other site 1146883010706 ABC transporter signature motif; other site 1146883010707 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1146883010708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883010709 NAD(P) binding site [chemical binding]; other site 1146883010710 active site 1146883010711 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1146883010712 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1146883010713 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1146883010714 CoA binding domain; Region: CoA_binding_2; pfam13380 1146883010715 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1146883010716 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1146883010717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883010718 dimer interface [polypeptide binding]; other site 1146883010719 conserved gate region; other site 1146883010720 ABC-ATPase subunit interface; other site 1146883010721 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1146883010722 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1146883010723 Walker A/P-loop; other site 1146883010724 ATP binding site [chemical binding]; other site 1146883010725 Q-loop/lid; other site 1146883010726 ABC transporter signature motif; other site 1146883010727 Walker B; other site 1146883010728 D-loop; other site 1146883010729 H-loop/switch region; other site 1146883010730 NMT1-like family; Region: NMT1_2; pfam13379 1146883010731 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1146883010732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1146883010733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883010734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1146883010735 dimerization interface [polypeptide binding]; other site 1146883010736 DNA polymerase II large subunit; Provisional; Region: PRK14714 1146883010737 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1146883010738 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1146883010739 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883010740 active site 1146883010741 DNA binding site [nucleotide binding] 1146883010742 Int/Topo IB signature motif; other site 1146883010743 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1146883010744 putative active site [active] 1146883010745 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883010746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1146883010747 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1146883010748 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1146883010749 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1146883010750 putative active site pocket [active] 1146883010751 metal binding site [ion binding]; metal-binding site 1146883010752 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1146883010753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1146883010754 DNA-binding site [nucleotide binding]; DNA binding site 1146883010755 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1146883010756 heat shock protein HtpX; Provisional; Region: PRK03072 1146883010757 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1146883010758 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1146883010759 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1146883010760 dimer interface [polypeptide binding]; other site 1146883010761 PYR/PP interface [polypeptide binding]; other site 1146883010762 TPP binding site [chemical binding]; other site 1146883010763 substrate binding site [chemical binding]; other site 1146883010764 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1146883010765 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1146883010766 TPP-binding site [chemical binding]; other site 1146883010767 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1146883010768 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1146883010769 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1146883010770 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1146883010771 substrate binding pocket [chemical binding]; other site 1146883010772 chain length determination region; other site 1146883010773 substrate-Mg2+ binding site; other site 1146883010774 catalytic residues [active] 1146883010775 aspartate-rich region 1; other site 1146883010776 active site lid residues [active] 1146883010777 aspartate-rich region 2; other site 1146883010778 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1146883010779 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883010780 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1146883010781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883010782 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1146883010783 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1146883010784 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1146883010785 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1146883010786 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1146883010787 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1146883010788 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1146883010789 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883010790 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883010791 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1146883010792 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1146883010793 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1146883010794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883010795 catalytic loop [active] 1146883010796 iron binding site [ion binding]; other site 1146883010797 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1146883010798 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883010799 molybdopterin cofactor binding site; other site 1146883010800 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1146883010801 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1146883010802 SLBB domain; Region: SLBB; pfam10531 1146883010803 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1146883010804 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1146883010805 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1146883010806 putative dimer interface [polypeptide binding]; other site 1146883010807 [2Fe-2S] cluster binding site [ion binding]; other site 1146883010808 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1146883010809 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1146883010810 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1146883010811 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1146883010812 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1146883010813 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1146883010814 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1146883010815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1146883010816 active site 1146883010817 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1146883010818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883010819 S-adenosylmethionine binding site [chemical binding]; other site 1146883010820 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1146883010821 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1146883010822 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1146883010823 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1146883010824 dimer interface [polypeptide binding]; other site 1146883010825 tetramer interface [polypeptide binding]; other site 1146883010826 PYR/PP interface [polypeptide binding]; other site 1146883010827 TPP binding site [chemical binding]; other site 1146883010828 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1146883010829 TPP-binding site [chemical binding]; other site 1146883010830 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1146883010831 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1146883010832 active site 1146883010833 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883010834 active site 1146883010835 CoA binding site [chemical binding]; other site 1146883010836 AMP binding site [chemical binding]; other site 1146883010837 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1146883010838 UbiA prenyltransferase family; Region: UbiA; pfam01040 1146883010839 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1146883010840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883010841 putative DNA binding site [nucleotide binding]; other site 1146883010842 putative Zn2+ binding site [ion binding]; other site 1146883010843 AsnC family; Region: AsnC_trans_reg; pfam01037 1146883010844 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1146883010845 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1146883010846 ResB-like family; Region: ResB; pfam05140 1146883010847 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1146883010848 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1146883010849 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1146883010850 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1146883010851 catalytic residues [active] 1146883010852 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883010853 catalytic core [active] 1146883010854 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1146883010855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1146883010856 inhibitor-cofactor binding pocket; inhibition site 1146883010857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883010858 catalytic residue [active] 1146883010859 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1146883010860 dimer interface [polypeptide binding]; other site 1146883010861 active site 1146883010862 Schiff base residues; other site 1146883010863 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1146883010864 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1146883010865 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1146883010866 active site 1146883010867 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1146883010868 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1146883010869 domain interfaces; other site 1146883010870 active site 1146883010871 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1146883010872 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1146883010873 tRNA; other site 1146883010874 putative tRNA binding site [nucleotide binding]; other site 1146883010875 putative NADP binding site [chemical binding]; other site 1146883010876 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1146883010877 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1146883010878 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1146883010879 CoA binding domain; Region: CoA_binding; pfam02629 1146883010880 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1146883010881 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1146883010882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883010883 acyl-activating enzyme (AAE) consensus motif; other site 1146883010884 AMP binding site [chemical binding]; other site 1146883010885 active site 1146883010886 CoA binding site [chemical binding]; other site 1146883010887 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1146883010888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1146883010889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1146883010890 DNA binding residues [nucleotide binding] 1146883010891 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1146883010892 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1146883010893 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1146883010894 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1146883010895 putative acyl-acceptor binding pocket; other site 1146883010896 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1146883010897 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1146883010898 putative NAD(P) binding site [chemical binding]; other site 1146883010899 active site 1146883010900 putative substrate binding site [chemical binding]; other site 1146883010901 DNA binding domain, excisionase family; Region: excise; TIGR01764 1146883010902 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1146883010903 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1146883010904 Proline dehydrogenase; Region: Pro_dh; cl03282 1146883010905 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1146883010906 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1146883010907 proposed catalytic triad [active] 1146883010908 conserved cys residue [active] 1146883010909 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1146883010910 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1146883010911 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1146883010912 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1146883010913 conserved cys residue [active] 1146883010914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1146883010915 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 1146883010916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883010917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883010918 active site 1146883010919 phosphorylation site [posttranslational modification] 1146883010920 intermolecular recognition site; other site 1146883010921 dimerization interface [polypeptide binding]; other site 1146883010922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883010923 DNA binding site [nucleotide binding] 1146883010924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883010925 dimer interface [polypeptide binding]; other site 1146883010926 phosphorylation site [posttranslational modification] 1146883010927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883010928 ATP binding site [chemical binding]; other site 1146883010929 Mg2+ binding site [ion binding]; other site 1146883010930 G-X-G motif; other site 1146883010931 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1146883010932 PhoU domain; Region: PhoU; pfam01895 1146883010933 PhoU domain; Region: PhoU; pfam01895 1146883010934 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883010935 catalytic core [active] 1146883010936 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1146883010937 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1146883010938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883010939 putative substrate translocation pore; other site 1146883010940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883010941 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1146883010942 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1146883010943 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1146883010944 putative ADP-binding pocket [chemical binding]; other site 1146883010945 malonic semialdehyde reductase; Provisional; Region: PRK10538 1146883010946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883010947 NAD(P) binding site [chemical binding]; other site 1146883010948 active site 1146883010949 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1146883010950 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883010951 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1146883010952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883010953 S-adenosylmethionine binding site [chemical binding]; other site 1146883010954 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1146883010955 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1146883010956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1146883010957 non-specific DNA binding site [nucleotide binding]; other site 1146883010958 salt bridge; other site 1146883010959 sequence-specific DNA binding site [nucleotide binding]; other site 1146883010960 L-asparaginase II; Region: Asparaginase_II; pfam06089 1146883010961 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1146883010962 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1146883010963 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1146883010964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1146883010965 metal binding site 2 [ion binding]; metal-binding site 1146883010966 putative DNA binding helix; other site 1146883010967 metal binding site 1 [ion binding]; metal-binding site 1146883010968 dimer interface [polypeptide binding]; other site 1146883010969 structural Zn2+ binding site [ion binding]; other site 1146883010970 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1146883010971 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1146883010972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883010973 catalytic residue [active] 1146883010974 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1146883010975 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1146883010976 MMPL family; Region: MMPL; pfam03176 1146883010977 MMPL family; Region: MMPL; pfam03176 1146883010978 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1146883010979 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1146883010980 heme-binding site [chemical binding]; other site 1146883010981 PAS domain; Region: PAS_9; pfam13426 1146883010982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883010983 PAS domain; Region: PAS_9; pfam13426 1146883010984 putative active site [active] 1146883010985 heme pocket [chemical binding]; other site 1146883010986 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883010987 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1146883010988 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1146883010989 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1146883010990 active site residue [active] 1146883010991 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1146883010992 active site residue [active] 1146883010993 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1146883010994 catalytic residues [active] 1146883010995 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1146883010996 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883010997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883010998 DNA binding site [nucleotide binding] 1146883010999 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1146883011000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883011001 Coenzyme A binding pocket [chemical binding]; other site 1146883011002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1146883011003 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1146883011004 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1146883011005 Walker A/P-loop; other site 1146883011006 ATP binding site [chemical binding]; other site 1146883011007 Q-loop/lid; other site 1146883011008 ABC transporter signature motif; other site 1146883011009 Walker B; other site 1146883011010 D-loop; other site 1146883011011 H-loop/switch region; other site 1146883011012 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1146883011013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883011014 dimer interface [polypeptide binding]; other site 1146883011015 conserved gate region; other site 1146883011016 putative PBP binding loops; other site 1146883011017 ABC-ATPase subunit interface; other site 1146883011018 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1146883011019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883011020 dimer interface [polypeptide binding]; other site 1146883011021 conserved gate region; other site 1146883011022 putative PBP binding loops; other site 1146883011023 ABC-ATPase subunit interface; other site 1146883011024 PBP superfamily domain; Region: PBP_like_2; cl17296 1146883011025 PBP superfamily domain; Region: PBP_like_2; cl17296 1146883011026 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1146883011027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883011028 dimer interface [polypeptide binding]; other site 1146883011029 conserved gate region; other site 1146883011030 putative PBP binding loops; other site 1146883011031 ABC-ATPase subunit interface; other site 1146883011032 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1146883011033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883011034 dimer interface [polypeptide binding]; other site 1146883011035 conserved gate region; other site 1146883011036 putative PBP binding loops; other site 1146883011037 ABC-ATPase subunit interface; other site 1146883011038 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1146883011039 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1146883011040 Walker A/P-loop; other site 1146883011041 ATP binding site [chemical binding]; other site 1146883011042 Q-loop/lid; other site 1146883011043 ABC transporter signature motif; other site 1146883011044 Walker B; other site 1146883011045 D-loop; other site 1146883011046 H-loop/switch region; other site 1146883011047 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1146883011048 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1146883011049 MAEBL; Provisional; Region: PTZ00121 1146883011050 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1146883011051 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1146883011052 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1146883011053 FAD binding pocket [chemical binding]; other site 1146883011054 FAD binding motif [chemical binding]; other site 1146883011055 phosphate binding motif [ion binding]; other site 1146883011056 NAD binding pocket [chemical binding]; other site 1146883011057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883011058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883011059 active site 1146883011060 phosphorylation site [posttranslational modification] 1146883011061 intermolecular recognition site; other site 1146883011062 dimerization interface [polypeptide binding]; other site 1146883011063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883011064 DNA binding site [nucleotide binding] 1146883011065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883011066 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883011067 dimerization interface [polypeptide binding]; other site 1146883011068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883011069 dimer interface [polypeptide binding]; other site 1146883011070 phosphorylation site [posttranslational modification] 1146883011071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883011072 Mg2+ binding site [ion binding]; other site 1146883011073 G-X-G motif; other site 1146883011074 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1146883011075 CoenzymeA binding site [chemical binding]; other site 1146883011076 subunit interaction site [polypeptide binding]; other site 1146883011077 PHB binding site; other site 1146883011078 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1146883011079 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1146883011080 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1146883011081 active site 1146883011082 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1146883011083 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1146883011084 Active Sites [active] 1146883011085 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1146883011086 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1146883011087 CysD dimerization site [polypeptide binding]; other site 1146883011088 G1 box; other site 1146883011089 putative GEF interaction site [polypeptide binding]; other site 1146883011090 GTP/Mg2+ binding site [chemical binding]; other site 1146883011091 Switch I region; other site 1146883011092 G2 box; other site 1146883011093 G3 box; other site 1146883011094 Switch II region; other site 1146883011095 G4 box; other site 1146883011096 G5 box; other site 1146883011097 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1146883011098 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1146883011099 amidase; Provisional; Region: PRK07486 1146883011100 Amidase; Region: Amidase; pfam01425 1146883011101 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1146883011102 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1146883011103 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 1146883011104 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1146883011105 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1146883011106 tetramerization interface [polypeptide binding]; other site 1146883011107 NAD(P) binding site [chemical binding]; other site 1146883011108 catalytic residues [active] 1146883011109 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1146883011110 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1146883011111 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1146883011112 active site 1146883011113 inhibitor site; inhibition site 1146883011114 dimer interface [polypeptide binding]; other site 1146883011115 catalytic residue [active] 1146883011116 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1146883011117 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1146883011118 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1146883011119 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1146883011120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883011121 NAD(P) binding site [chemical binding]; other site 1146883011122 active site 1146883011123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1146883011124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1146883011125 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1146883011126 substrate binding pocket [chemical binding]; other site 1146883011127 dimerization interface [polypeptide binding]; other site 1146883011128 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1146883011129 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1146883011130 active site 1146883011131 metal binding site [ion binding]; metal-binding site 1146883011132 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1146883011133 active site 1146883011134 metal binding site [ion binding]; metal-binding site 1146883011135 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1146883011136 classical (c) SDRs; Region: SDR_c; cd05233 1146883011137 NAD(P) binding site [chemical binding]; other site 1146883011138 active site 1146883011139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883011140 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1146883011141 active site 1146883011142 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1146883011143 inter-subunit interface; other site 1146883011144 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1146883011145 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1146883011146 [2Fe-2S] cluster binding site [ion binding]; other site 1146883011147 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1146883011148 beta subunit interface [polypeptide binding]; other site 1146883011149 alpha subunit interface [polypeptide binding]; other site 1146883011150 active site 1146883011151 substrate binding site [chemical binding]; other site 1146883011152 Fe binding site [ion binding]; other site 1146883011153 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1146883011154 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1146883011155 Walker A/P-loop; other site 1146883011156 ATP binding site [chemical binding]; other site 1146883011157 Q-loop/lid; other site 1146883011158 ABC transporter signature motif; other site 1146883011159 Walker B; other site 1146883011160 D-loop; other site 1146883011161 H-loop/switch region; other site 1146883011162 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1146883011163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1146883011164 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1146883011165 ligand binding site [chemical binding]; other site 1146883011166 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883011167 TM-ABC transporter signature motif; other site 1146883011168 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1146883011169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883011170 dimerization interface [polypeptide binding]; other site 1146883011171 putative DNA binding site [nucleotide binding]; other site 1146883011172 putative Zn2+ binding site [ion binding]; other site 1146883011173 Bacterial transcriptional regulator; Region: IclR; pfam01614 1146883011174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1146883011175 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1146883011176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1146883011177 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1146883011178 Cytochrome P450; Region: p450; cl12078 1146883011179 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883011180 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1146883011181 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1146883011182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883011183 ATP binding site [chemical binding]; other site 1146883011184 putative Mg++ binding site [ion binding]; other site 1146883011185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883011186 nucleotide binding region [chemical binding]; other site 1146883011187 ATP-binding site [chemical binding]; other site 1146883011188 Helicase associated domain (HA2); Region: HA2; pfam04408 1146883011189 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1146883011190 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1146883011191 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883011192 MarR family; Region: MarR; pfam01047 1146883011193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011194 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1146883011195 putative substrate translocation pore; other site 1146883011196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011197 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1146883011198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883011199 active site 1146883011200 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1146883011201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011203 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1146883011204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883011205 acyl-coenzyme A oxidase; Region: PLN02526 1146883011206 active site 1146883011207 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1146883011208 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1146883011209 active site 1146883011210 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1146883011211 ATP binding site [chemical binding]; other site 1146883011212 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1146883011213 active site 1146883011214 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1146883011215 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1146883011216 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1146883011217 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1146883011218 TAP-like protein; Region: Abhydrolase_4; pfam08386 1146883011219 BCCT family transporter; Region: BCCT; cl00569 1146883011220 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1146883011221 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1146883011222 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1146883011223 putative active site [active] 1146883011224 putative active site [active] 1146883011225 catalytic site [active] 1146883011226 catalytic site [active] 1146883011227 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1146883011228 putative active site [active] 1146883011229 catalytic site [active] 1146883011230 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1146883011231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883011232 Walker A/P-loop; other site 1146883011233 ATP binding site [chemical binding]; other site 1146883011234 Q-loop/lid; other site 1146883011235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883011236 ABC transporter signature motif; other site 1146883011237 Walker B; other site 1146883011238 D-loop; other site 1146883011239 H-loop/switch region; other site 1146883011240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883011241 Walker A/P-loop; other site 1146883011242 ATP binding site [chemical binding]; other site 1146883011243 Q-loop/lid; other site 1146883011244 ABC transporter signature motif; other site 1146883011245 Walker B; other site 1146883011246 D-loop; other site 1146883011247 H-loop/switch region; other site 1146883011248 potential frameshift: common BLAST hit: gi|284990526|ref|YP_003409080.1| LigA 1146883011249 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1146883011250 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883011251 active site 1146883011252 DNA binding site [nucleotide binding] 1146883011253 Int/Topo IB signature motif; other site 1146883011254 malate:quinone oxidoreductase; Validated; Region: PRK05257 1146883011255 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1146883011256 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1146883011257 iron-sulfur cluster [ion binding]; other site 1146883011258 [2Fe-2S] cluster binding site [ion binding]; other site 1146883011259 Predicted membrane protein [Function unknown]; Region: COG2246 1146883011260 GtrA-like protein; Region: GtrA; pfam04138 1146883011261 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1146883011262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1146883011263 active site 1146883011264 metal binding site [ion binding]; metal-binding site 1146883011265 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1146883011266 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883011267 acyl-activating enzyme (AAE) consensus motif; other site 1146883011268 AMP binding site [chemical binding]; other site 1146883011269 active site 1146883011270 CoA binding site [chemical binding]; other site 1146883011271 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1146883011272 active site 1146883011273 substrate binding pocket [chemical binding]; other site 1146883011274 homodimer interaction site [polypeptide binding]; other site 1146883011275 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1146883011276 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1146883011277 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1146883011278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1146883011279 acyl-activating enzyme (AAE) consensus motif; other site 1146883011280 AMP binding site [chemical binding]; other site 1146883011281 active site 1146883011282 CoA binding site [chemical binding]; other site 1146883011283 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1146883011284 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1146883011285 Peptidase family M23; Region: Peptidase_M23; pfam01551 1146883011286 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883011287 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1146883011288 Walker A/P-loop; other site 1146883011289 ATP binding site [chemical binding]; other site 1146883011290 Q-loop/lid; other site 1146883011291 ABC transporter signature motif; other site 1146883011292 Walker B; other site 1146883011293 D-loop; other site 1146883011294 H-loop/switch region; other site 1146883011295 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883011296 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883011297 TM-ABC transporter signature motif; other site 1146883011298 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1146883011299 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1146883011300 putative ligand binding site [chemical binding]; other site 1146883011301 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1146883011302 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1146883011303 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1146883011304 NAD(P) binding pocket [chemical binding]; other site 1146883011305 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1146883011306 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1146883011307 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1146883011308 dimerization interface [polypeptide binding]; other site 1146883011309 putative ATP binding site [chemical binding]; other site 1146883011310 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1146883011311 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1146883011312 active site 1146883011313 tetramer interface [polypeptide binding]; other site 1146883011314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1146883011315 active site 1146883011316 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1146883011317 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1146883011318 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1146883011319 NAD binding site [chemical binding]; other site 1146883011320 catalytic Zn binding site [ion binding]; other site 1146883011321 substrate binding site [chemical binding]; other site 1146883011322 structural Zn binding site [ion binding]; other site 1146883011323 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1146883011324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011325 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1146883011326 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1146883011327 dimerization interface [polypeptide binding]; other site 1146883011328 ATP binding site [chemical binding]; other site 1146883011329 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1146883011330 dimerization interface [polypeptide binding]; other site 1146883011331 ATP binding site [chemical binding]; other site 1146883011332 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1146883011333 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1146883011334 putative active site [active] 1146883011335 catalytic triad [active] 1146883011336 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1146883011337 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1146883011338 ATP binding site [chemical binding]; other site 1146883011339 active site 1146883011340 substrate binding site [chemical binding]; other site 1146883011341 adenylosuccinate lyase; Provisional; Region: PRK07492 1146883011342 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1146883011343 tetramer interface [polypeptide binding]; other site 1146883011344 active site 1146883011345 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1146883011346 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1146883011347 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1146883011348 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1146883011349 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1146883011350 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1146883011351 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1146883011352 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1146883011353 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1146883011354 active site 1146883011355 catalytic site [active] 1146883011356 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1146883011357 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1146883011358 GDP-binding site [chemical binding]; other site 1146883011359 ACT binding site; other site 1146883011360 IMP binding site; other site 1146883011361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883011362 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883011363 TM-ABC transporter signature motif; other site 1146883011364 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1146883011365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883011366 Walker A/P-loop; other site 1146883011367 ATP binding site [chemical binding]; other site 1146883011368 Q-loop/lid; other site 1146883011369 ABC transporter signature motif; other site 1146883011370 Walker B; other site 1146883011371 D-loop; other site 1146883011372 H-loop/switch region; other site 1146883011373 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1146883011374 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1146883011375 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1146883011376 active site 1146883011377 intersubunit interface [polypeptide binding]; other site 1146883011378 zinc binding site [ion binding]; other site 1146883011379 Na+ binding site [ion binding]; other site 1146883011380 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1146883011381 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1146883011382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1146883011383 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1146883011384 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1146883011385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883011386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883011387 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1146883011388 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883011389 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1146883011390 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 1146883011391 Fasciclin domain; Region: Fasciclin; pfam02469 1146883011392 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1146883011393 Clp amino terminal domain; Region: Clp_N; pfam02861 1146883011394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883011395 Walker A motif; other site 1146883011396 ATP binding site [chemical binding]; other site 1146883011397 Walker B motif; other site 1146883011398 arginine finger; other site 1146883011399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883011400 Walker A motif; other site 1146883011401 ATP binding site [chemical binding]; other site 1146883011402 Walker B motif; other site 1146883011403 arginine finger; other site 1146883011404 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1146883011405 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1146883011406 MarR family; Region: MarR; pfam01047 1146883011407 OsmC-like protein; Region: OsmC; cl00767 1146883011408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1146883011410 putative substrate translocation pore; other site 1146883011411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011412 putative substrate translocation pore; other site 1146883011413 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1146883011414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883011415 putative DNA binding site [nucleotide binding]; other site 1146883011416 putative Zn2+ binding site [ion binding]; other site 1146883011417 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1146883011418 DNA binding residues [nucleotide binding] 1146883011419 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883011420 putative dimer interface [polypeptide binding]; other site 1146883011421 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1146883011422 HSP70 interaction site [polypeptide binding]; other site 1146883011423 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1146883011424 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1146883011425 Zn binding sites [ion binding]; other site 1146883011426 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1146883011427 dimer interface [polypeptide binding]; other site 1146883011428 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1146883011429 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1146883011430 dimer interface [polypeptide binding]; other site 1146883011431 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1146883011432 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1146883011433 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1146883011434 nucleotide binding site [chemical binding]; other site 1146883011435 NEF interaction site [polypeptide binding]; other site 1146883011436 SBD interface [polypeptide binding]; other site 1146883011437 Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998 1146883011438 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1146883011439 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1146883011440 active site 1146883011441 putative catalytic site [active] 1146883011442 CHRD domain; Region: CHRD; cl06473 1146883011443 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1146883011444 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883011445 Cysteine-rich domain; Region: CCG; pfam02754 1146883011446 Cysteine-rich domain; Region: CCG; pfam02754 1146883011447 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1146883011448 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1146883011449 trimer interface [polypeptide binding]; other site 1146883011450 active site 1146883011451 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 1146883011452 catalytic triad [active] 1146883011453 putative active site [active] 1146883011454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883011455 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1146883011456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1146883011457 Histidine kinase; Region: HisKA_3; pfam07730 1146883011458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883011459 ATP binding site [chemical binding]; other site 1146883011460 Mg2+ binding site [ion binding]; other site 1146883011461 G-X-G motif; other site 1146883011462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1146883011463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883011464 active site 1146883011465 phosphorylation site [posttranslational modification] 1146883011466 intermolecular recognition site; other site 1146883011467 dimerization interface [polypeptide binding]; other site 1146883011468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1146883011469 DNA binding residues [nucleotide binding] 1146883011470 dimerization interface [polypeptide binding]; other site 1146883011471 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1146883011472 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1146883011473 active site 1146883011474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883011475 S-adenosylmethionine binding site [chemical binding]; other site 1146883011476 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1146883011477 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1146883011478 substrate binding site [chemical binding]; other site 1146883011479 ATP binding site [chemical binding]; other site 1146883011480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1146883011481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883011482 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883011483 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1146883011484 Integrase core domain; Region: rve; pfam00665 1146883011485 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1146883011486 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883011487 active site 1146883011488 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1146883011489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1146883011490 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1146883011491 DDE superfamily endonuclease; Region: DDE_5; cl17874 1146883011492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883011493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1146883011494 active site 1146883011495 GAF domain; Region: GAF; pfam01590 1146883011496 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883011497 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1146883011498 GAF domain; Region: GAF_3; pfam13492 1146883011499 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883011500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883011501 metal binding site [ion binding]; metal-binding site 1146883011502 active site 1146883011503 I-site; other site 1146883011504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883011505 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883011506 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883011507 metal binding site [ion binding]; metal-binding site 1146883011508 active site 1146883011509 I-site; other site 1146883011510 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1146883011511 putative hydrophobic ligand binding site [chemical binding]; other site 1146883011512 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1146883011513 E3 interaction surface; other site 1146883011514 lipoyl attachment site [posttranslational modification]; other site 1146883011515 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1146883011516 e3 binding domain; Region: E3_binding; pfam02817 1146883011517 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1146883011518 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1146883011519 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1146883011520 alpha subunit interface [polypeptide binding]; other site 1146883011521 TPP binding site [chemical binding]; other site 1146883011522 heterodimer interface [polypeptide binding]; other site 1146883011523 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1146883011524 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1146883011525 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1146883011526 TPP-binding site [chemical binding]; other site 1146883011527 heterodimer interface [polypeptide binding]; other site 1146883011528 tetramer interface [polypeptide binding]; other site 1146883011529 phosphorylation loop region [posttranslational modification] 1146883011530 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1146883011531 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1146883011532 AsnC family; Region: AsnC_trans_reg; pfam01037 1146883011533 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1146883011534 potential frameshift: common BLAST hit: gi|118467119|ref|YP_880369.1| M42 glutamyl aminopeptidase 1146883011535 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1146883011536 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 1146883011537 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1146883011538 Beta-lactamase; Region: Beta-lactamase; pfam00144 1146883011539 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1146883011540 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883011541 NlpC/P60 family; Region: NLPC_P60; pfam00877 1146883011542 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1146883011543 Transglycosylase; Region: Transgly; pfam00912 1146883011544 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1146883011545 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1146883011546 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1146883011547 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1146883011548 NAD(P) binding site [chemical binding]; other site 1146883011549 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1146883011550 active site 1146883011551 substrate-binding site [chemical binding]; other site 1146883011552 metal-binding site [ion binding] 1146883011553 GTP binding site [chemical binding]; other site 1146883011554 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1146883011555 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1146883011556 active site 1146883011557 FMN binding site [chemical binding]; other site 1146883011558 substrate binding site [chemical binding]; other site 1146883011559 homotetramer interface [polypeptide binding]; other site 1146883011560 catalytic residue [active] 1146883011561 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1146883011562 putative hydrophobic ligand binding site [chemical binding]; other site 1146883011563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883011564 dimerization interface [polypeptide binding]; other site 1146883011565 putative DNA binding site [nucleotide binding]; other site 1146883011566 putative Zn2+ binding site [ion binding]; other site 1146883011567 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1146883011568 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1146883011569 FMN binding site [chemical binding]; other site 1146883011570 substrate binding site [chemical binding]; other site 1146883011571 putative catalytic residue [active] 1146883011572 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1146883011573 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1146883011574 catalytic residues [active] 1146883011575 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1146883011576 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1146883011577 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1146883011578 Ca binding site [ion binding]; other site 1146883011579 active site 1146883011580 catalytic site [active] 1146883011581 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1146883011582 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1146883011583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883011584 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883011585 active site 1146883011586 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1146883011587 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1146883011588 acyl-activating enzyme (AAE) consensus motif; other site 1146883011589 putative AMP binding site [chemical binding]; other site 1146883011590 putative active site [active] 1146883011591 putative CoA binding site [chemical binding]; other site 1146883011592 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1146883011593 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1146883011594 catalytic residues [active] 1146883011595 dimer interface [polypeptide binding]; other site 1146883011596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1146883011597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1146883011598 ABC-ATPase subunit interface; other site 1146883011599 dimer interface [polypeptide binding]; other site 1146883011600 putative PBP binding regions; other site 1146883011601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1146883011602 dimer interface [polypeptide binding]; other site 1146883011603 putative PBP binding regions; other site 1146883011604 ABC-ATPase subunit interface; other site 1146883011605 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1146883011606 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1146883011607 Walker A/P-loop; other site 1146883011608 ATP binding site [chemical binding]; other site 1146883011609 Q-loop/lid; other site 1146883011610 ABC transporter signature motif; other site 1146883011611 Walker B; other site 1146883011612 D-loop; other site 1146883011613 H-loop/switch region; other site 1146883011614 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1146883011615 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1146883011616 intersubunit interface [polypeptide binding]; other site 1146883011617 EamA-like transporter family; Region: EamA; pfam00892 1146883011618 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883011619 anti sigma factor interaction site; other site 1146883011620 regulatory phosphorylation site [posttranslational modification]; other site 1146883011621 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1146883011622 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1146883011623 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1146883011624 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1146883011625 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1146883011626 homodimer interface [polypeptide binding]; other site 1146883011627 substrate-cofactor binding pocket; other site 1146883011628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883011629 catalytic residue [active] 1146883011630 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1146883011631 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1146883011632 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1146883011633 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1146883011634 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1146883011635 catalytic residue [active] 1146883011636 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1146883011637 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1146883011638 trimer interface [polypeptide binding]; other site 1146883011639 putative metal binding site [ion binding]; other site 1146883011640 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1146883011641 methionine synthase; Provisional; Region: PRK01207 1146883011642 substrate binding site [chemical binding]; other site 1146883011643 THF binding site; other site 1146883011644 zinc-binding site [ion binding]; other site 1146883011645 glutamate dehydrogenase; Provisional; Region: PRK09414 1146883011646 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1146883011647 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1146883011648 NAD(P) binding site [chemical binding]; other site 1146883011649 NlpC/P60 family; Region: NLPC_P60; pfam00877 1146883011650 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1146883011651 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1146883011652 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1146883011653 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1146883011654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1146883011655 mercuric reductase; Validated; Region: PRK06370 1146883011656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883011657 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1146883011658 hypothetical protein; Provisional; Region: PRK11622 1146883011659 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1146883011660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883011661 ABC-ATPase subunit interface; other site 1146883011662 putative PBP binding loops; other site 1146883011663 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1146883011664 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1146883011665 Walker A/P-loop; other site 1146883011666 ATP binding site [chemical binding]; other site 1146883011667 Q-loop/lid; other site 1146883011668 ABC transporter signature motif; other site 1146883011669 Walker B; other site 1146883011670 D-loop; other site 1146883011671 H-loop/switch region; other site 1146883011672 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1146883011673 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1146883011674 Cupin domain; Region: Cupin_2; cl17218 1146883011675 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1146883011676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1146883011677 guanine deaminase; Region: guan_deamin; TIGR02967 1146883011678 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1146883011679 active site 1146883011680 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1146883011681 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1146883011682 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1146883011683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1146883011684 motif II; other site 1146883011685 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1146883011686 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546 1146883011687 putative active site [active] 1146883011688 redox center [active] 1146883011689 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1146883011690 putative hydrophobic ligand binding site [chemical binding]; other site 1146883011691 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1146883011692 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1146883011693 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1146883011694 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1146883011695 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1146883011696 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1146883011697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883011698 catalytic loop [active] 1146883011699 iron binding site [ion binding]; other site 1146883011700 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1146883011701 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1146883011702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011703 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1146883011704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011705 putative substrate translocation pore; other site 1146883011706 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1146883011707 active site 1146883011708 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1146883011709 potential frameshift: common BLAST hit: gi|284993275|ref|YP_003411830.1| family 2 glycosyl transferase 1146883011710 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1146883011711 Isochorismatase family; Region: Isochorismatase; pfam00857 1146883011712 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1146883011713 catalytic triad [active] 1146883011714 conserved cis-peptide bond; other site 1146883011715 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1146883011716 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1146883011717 siderophore binding site; other site 1146883011718 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1146883011719 hypothetical protein; Provisional; Region: PRK01842 1146883011720 SEC-C motif; Region: SEC-C; pfam02810 1146883011721 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1146883011722 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1146883011723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883011724 FeS/SAM binding site; other site 1146883011725 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1146883011726 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1146883011727 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1146883011728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1146883011729 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1146883011730 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1146883011731 phosphate binding site [ion binding]; other site 1146883011732 FAD binding domain; Region: FAD_binding_3; pfam01494 1146883011733 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1146883011734 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1146883011735 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1146883011736 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1146883011737 NAD binding site [chemical binding]; other site 1146883011738 catalytic Zn binding site [ion binding]; other site 1146883011739 substrate binding site [chemical binding]; other site 1146883011740 structural Zn binding site [ion binding]; other site 1146883011741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883011742 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1146883011743 Walker A motif; other site 1146883011744 ATP binding site [chemical binding]; other site 1146883011745 Walker B motif; other site 1146883011746 arginine finger; other site 1146883011747 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1146883011748 metal ion-dependent adhesion site (MIDAS); other site 1146883011749 MOSC domain; Region: MOSC; pfam03473 1146883011750 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1146883011751 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1146883011752 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1146883011753 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1146883011754 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1146883011755 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1146883011756 metal ion-dependent adhesion site (MIDAS); other site 1146883011757 MoxR-like ATPases [General function prediction only]; Region: COG0714 1146883011758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883011759 Walker A motif; other site 1146883011760 ATP binding site [chemical binding]; other site 1146883011761 Walker B motif; other site 1146883011762 arginine finger; other site 1146883011763 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1146883011764 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1146883011765 active site 1146883011766 metal binding site [ion binding]; metal-binding site 1146883011767 PRC-barrel domain; Region: PRC; pfam05239 1146883011768 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1146883011769 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1146883011770 PRC-barrel domain; Region: PRC; pfam05239 1146883011771 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1146883011772 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1146883011773 active site 1146883011774 catalytic tetrad [active] 1146883011775 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1146883011776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1146883011777 FeS/SAM binding site; other site 1146883011778 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1146883011779 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1146883011780 MoaE interaction surface [polypeptide binding]; other site 1146883011781 MoeB interaction surface [polypeptide binding]; other site 1146883011782 thiocarboxylated glycine; other site 1146883011783 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1146883011784 MoaD interaction [polypeptide binding]; other site 1146883011785 active site residues [active] 1146883011786 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1146883011787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883011788 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1146883011789 Walker A/P-loop; other site 1146883011790 ATP binding site [chemical binding]; other site 1146883011791 Q-loop/lid; other site 1146883011792 ABC transporter signature motif; other site 1146883011793 Walker B; other site 1146883011794 D-loop; other site 1146883011795 H-loop/switch region; other site 1146883011796 TOBE domain; Region: TOBE; cl01440 1146883011797 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1146883011798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1146883011799 putative PBP binding loops; other site 1146883011800 ABC-ATPase subunit interface; other site 1146883011801 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1146883011802 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1146883011803 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883011804 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1146883011805 DNA binding residues [nucleotide binding] 1146883011806 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1146883011807 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1146883011808 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1146883011809 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1146883011810 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1146883011811 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1146883011812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883011813 ATP binding site [chemical binding]; other site 1146883011814 putative Mg++ binding site [ion binding]; other site 1146883011815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883011816 nucleotide binding region [chemical binding]; other site 1146883011817 ATP-binding site [chemical binding]; other site 1146883011818 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1146883011819 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1146883011820 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1146883011821 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1146883011822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883011823 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883011824 active site 1146883011825 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1146883011826 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1146883011827 homodimer interface [polypeptide binding]; other site 1146883011828 putative substrate binding pocket [chemical binding]; other site 1146883011829 diiron center [ion binding]; other site 1146883011830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1146883011831 Coenzyme A binding pocket [chemical binding]; other site 1146883011832 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1146883011833 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1146883011834 putative catalytic site [active] 1146883011835 putative phosphate binding site [ion binding]; other site 1146883011836 active site 1146883011837 metal binding site A [ion binding]; metal-binding site 1146883011838 DNA binding site [nucleotide binding] 1146883011839 putative AP binding site [nucleotide binding]; other site 1146883011840 putative metal binding site B [ion binding]; other site 1146883011841 integrase; Provisional; Region: int; PHA02601 1146883011842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883011843 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1146883011844 active site 1146883011845 DNA binding site [nucleotide binding] 1146883011846 Int/Topo IB signature motif; other site 1146883011847 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883011848 potential frameshift: common BLAST hit: gi|284990000|ref|YP_003408554.1| TrwC relaxase 1146883011849 AAA domain; Region: AAA_30; pfam13604 1146883011850 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1146883011851 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1146883011852 gating phenylalanine in ion channel; other site 1146883011853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1146883011854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1146883011855 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1146883011856 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1146883011857 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1146883011858 potential frameshift: common BLAST hit: gi|119715582|ref|YP_922547.1| respiratory nitrate reductase subunit alpha 1146883011859 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1146883011860 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883011861 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883011862 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883011863 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1146883011864 molybdopterin cofactor binding site; other site 1146883011865 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1146883011866 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1146883011867 [4Fe-4S] binding site [ion binding]; other site 1146883011868 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1146883011869 Ferredoxin [Energy production and conversion]; Region: COG1146 1146883011870 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883011871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1146883011872 putative DNA binding site [nucleotide binding]; other site 1146883011873 Predicted transcriptional regulator [Transcription]; Region: COG2345 1146883011874 putative Zn2+ binding site [ion binding]; other site 1146883011875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1146883011876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1146883011877 active site 1146883011878 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1146883011879 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1146883011880 catalytic residues [active] 1146883011881 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1146883011882 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1146883011883 Predicted transcriptional regulator [Transcription]; Region: COG2345 1146883011884 putative DNA binding site [nucleotide binding]; other site 1146883011885 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1146883011886 putative Zn2+ binding site [ion binding]; other site 1146883011887 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1146883011888 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1146883011889 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1146883011890 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1146883011891 Ferredoxin [Energy production and conversion]; Region: COG1146 1146883011892 4Fe-4S binding domain; Region: Fer4; pfam00037 1146883011893 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1146883011894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1146883011895 putative DNA binding site [nucleotide binding]; other site 1146883011896 Predicted transcriptional regulator [Transcription]; Region: COG2345 1146883011897 putative Zn2+ binding site [ion binding]; other site 1146883011898 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1146883011899 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1146883011900 D-pathway; other site 1146883011901 Putative ubiquinol binding site [chemical binding]; other site 1146883011902 Low-spin heme (heme b) binding site [chemical binding]; other site 1146883011903 Putative water exit pathway; other site 1146883011904 Binuclear center (heme o3/CuB) [ion binding]; other site 1146883011905 K-pathway; other site 1146883011906 Putative proton exit pathway; other site 1146883011907 Helix-turn-helix domain; Region: HTH_17; cl17695 1146883011908 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1146883011909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1146883011910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883011911 S-adenosylmethionine binding site [chemical binding]; other site 1146883011912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1146883011913 Lsr2; Region: Lsr2; pfam11774 1146883011914 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883011915 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1146883011916 anti sigma factor interaction site; other site 1146883011917 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1146883011918 regulatory phosphorylation site [posttranslational modification]; other site 1146883011919 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883011920 GAF domain; Region: GAF; cl17456 1146883011921 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1146883011922 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1146883011923 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 1146883011924 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883011925 active site 1146883011926 catalytic residues [active] 1146883011927 DNA binding site [nucleotide binding] 1146883011928 Int/Topo IB signature motif; other site 1146883011929 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1146883011930 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1146883011931 active site 1146883011932 catalytic residues [active] 1146883011933 DNA binding site [nucleotide binding] 1146883011934 Int/Topo IB signature motif; other site 1146883011935 Helix-turn-helix domain; Region: HTH_17; pfam12728 1146883011936 putative transposase OrfB; Reviewed; Region: PHA02517 1146883011937 Homeodomain-like domain; Region: HTH_32; pfam13565 1146883011938 Integrase core domain; Region: rve; pfam00665 1146883011939 Integrase core domain; Region: rve_3; pfam13683 1146883011940 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1146883011941 Helix-turn-helix domain; Region: HTH_38; pfam13936 1146883011942 Integrase core domain; Region: rve; pfam00665 1146883011943 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1146883011944 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1146883011945 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1146883011946 siderophore binding site; other site 1146883011947 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1146883011948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1146883011949 ABC-ATPase subunit interface; other site 1146883011950 dimer interface [polypeptide binding]; other site 1146883011951 putative PBP binding regions; other site 1146883011952 FecCD transport family; Region: FecCD; pfam01032 1146883011953 ABC-ATPase subunit interface; other site 1146883011954 dimer interface [polypeptide binding]; other site 1146883011955 putative PBP binding regions; other site 1146883011956 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1146883011957 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1146883011958 Q-loop/lid; other site 1146883011959 ABC transporter signature motif; other site 1146883011960 Walker B; other site 1146883011961 D-loop; other site 1146883011962 H-loop/switch region; other site 1146883011963 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883011964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1146883011965 dimer interface [polypeptide binding]; other site 1146883011966 putative CheW interface [polypeptide binding]; other site 1146883011967 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1146883011968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1146883011969 dimerization interface [polypeptide binding]; other site 1146883011970 Integrase core domain; Region: rve; pfam00665 1146883011971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1146883011972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883011973 Walker A motif; other site 1146883011974 ATP binding site [chemical binding]; other site 1146883011975 Walker B motif; other site 1146883011976 RES domain; Region: RES; pfam08808 1146883011977 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1146883011978 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1146883011979 putative metal binding site [ion binding]; other site 1146883011980 hypothetical protein; Validated; Region: PRK02101 1146883011981 GAF domain; Region: GAF; pfam01590 1146883011982 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883011983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883011984 PAS fold; Region: PAS_3; pfam08447 1146883011985 putative active site [active] 1146883011986 heme pocket [chemical binding]; other site 1146883011987 PAS fold; Region: PAS_4; pfam08448 1146883011988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883011989 putative active site [active] 1146883011990 heme pocket [chemical binding]; other site 1146883011991 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1146883011992 GAF domain; Region: GAF; cl17456 1146883011993 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1146883011994 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1146883011995 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1146883011996 ATP binding site [chemical binding]; other site 1146883011997 Mg++ binding site [ion binding]; other site 1146883011998 motif III; other site 1146883011999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1146883012000 nucleotide binding region [chemical binding]; other site 1146883012001 ATP-binding site [chemical binding]; other site 1146883012002 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1146883012003 RNA binding site [nucleotide binding]; other site 1146883012004 amidase; Provisional; Region: PRK07486 1146883012005 Amidase; Region: Amidase; pfam01425 1146883012006 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1146883012007 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1146883012008 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1146883012009 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1146883012010 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1146883012011 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1146883012012 Membrane protein of unknown function; Region: DUF360; pfam04020 1146883012013 AAA ATPase domain; Region: AAA_16; pfam13191 1146883012014 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1146883012015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883012016 ATP binding site [chemical binding]; other site 1146883012017 Mg2+ binding site [ion binding]; other site 1146883012018 G-X-G motif; other site 1146883012019 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883012020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883012021 active site 1146883012022 phosphorylation site [posttranslational modification] 1146883012023 intermolecular recognition site; other site 1146883012024 dimerization interface [polypeptide binding]; other site 1146883012025 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1146883012026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883012027 Response regulator receiver domain; Region: Response_reg; pfam00072 1146883012028 active site 1146883012029 phosphorylation site [posttranslational modification] 1146883012030 intermolecular recognition site; other site 1146883012031 dimerization interface [polypeptide binding]; other site 1146883012032 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1146883012033 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1146883012034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883012035 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1146883012036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883012037 active site 1146883012038 phosphorylation site [posttranslational modification] 1146883012039 intermolecular recognition site; other site 1146883012040 dimerization interface [polypeptide binding]; other site 1146883012041 CheB methylesterase; Region: CheB_methylest; pfam01339 1146883012042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1146883012043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1146883012044 active site 1146883012045 phosphorylation site [posttranslational modification] 1146883012046 intermolecular recognition site; other site 1146883012047 dimerization interface [polypeptide binding]; other site 1146883012048 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1146883012049 DNA binding site [nucleotide binding] 1146883012050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883012051 dimerization interface [polypeptide binding]; other site 1146883012052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1146883012053 phosphorylation site [posttranslational modification] 1146883012054 dimer interface [polypeptide binding]; other site 1146883012055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883012056 Mg2+ binding site [ion binding]; other site 1146883012057 G-X-G motif; other site 1146883012058 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1146883012059 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1146883012060 putative binding surface; other site 1146883012061 active site 1146883012062 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1146883012063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883012064 ATP binding site [chemical binding]; other site 1146883012065 Mg2+ binding site [ion binding]; other site 1146883012066 G-X-G motif; other site 1146883012067 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1146883012068 CheW-like domain; Region: CheW; pfam01584 1146883012069 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1146883012070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883012071 dimerization interface [polypeptide binding]; other site 1146883012072 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1146883012073 dimer interface [polypeptide binding]; other site 1146883012074 putative CheW interface [polypeptide binding]; other site 1146883012075 GAF domain; Region: GAF; cl17456 1146883012076 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883012077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883012078 metal binding site [ion binding]; metal-binding site 1146883012079 active site 1146883012080 I-site; other site 1146883012081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1146883012082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1146883012083 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1146883012084 dimer interface [polypeptide binding]; other site 1146883012085 putative CheW interface [polypeptide binding]; other site 1146883012086 potential frameshift: common BLAST hit: gi|284993352|ref|YP_003411907.1| methyl-accepting chemotaxis sensory transducer 1146883012087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1146883012088 dimerization interface [polypeptide binding]; other site 1146883012089 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1146883012090 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1146883012091 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1146883012092 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1146883012093 active site 1146883012094 homotetramer interface [polypeptide binding]; other site 1146883012095 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1146883012096 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883012097 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883012098 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 1146883012099 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1146883012100 oligomeric interface; other site 1146883012101 putative active site [active] 1146883012102 homodimer interface [polypeptide binding]; other site 1146883012103 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1146883012104 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1146883012105 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1146883012106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883012107 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1146883012108 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1146883012109 active site 1146883012110 dimer interface [polypeptide binding]; other site 1146883012111 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1146883012112 Ligand Binding Site [chemical binding]; other site 1146883012113 Molecular Tunnel; other site 1146883012114 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1146883012115 active site 1146883012116 catalytic residues [active] 1146883012117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1146883012118 H-loop/switch region; other site 1146883012119 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1146883012120 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1146883012121 active site 1146883012122 catalytic residues [active] 1146883012123 metal binding site [ion binding]; metal-binding site 1146883012124 PAS domain S-box; Region: sensory_box; TIGR00229 1146883012125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1146883012126 putative active site [active] 1146883012127 heme pocket [chemical binding]; other site 1146883012128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1146883012129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1146883012130 metal binding site [ion binding]; metal-binding site 1146883012131 active site 1146883012132 I-site; other site 1146883012133 glycerol kinase; Provisional; Region: glpK; PRK00047 1146883012134 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1146883012135 N- and C-terminal domain interface [polypeptide binding]; other site 1146883012136 active site 1146883012137 MgATP binding site [chemical binding]; other site 1146883012138 catalytic site [active] 1146883012139 metal binding site [ion binding]; metal-binding site 1146883012140 putative homotetramer interface [polypeptide binding]; other site 1146883012141 glycerol binding site [chemical binding]; other site 1146883012142 homodimer interface [polypeptide binding]; other site 1146883012143 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1146883012144 active site 1146883012145 catalytic site [active] 1146883012146 trehalose synthase; Region: treS_nterm; TIGR02456 1146883012147 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1146883012148 active site 1146883012149 catalytic site [active] 1146883012150 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1146883012151 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1146883012152 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1146883012153 active site 1146883012154 substrate binding pocket [chemical binding]; other site 1146883012155 homodimer interaction site [polypeptide binding]; other site 1146883012156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1146883012157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1146883012158 TM-ABC transporter signature motif; other site 1146883012159 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1146883012160 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1146883012161 Walker A/P-loop; other site 1146883012162 ATP binding site [chemical binding]; other site 1146883012163 Q-loop/lid; other site 1146883012164 ABC transporter signature motif; other site 1146883012165 Walker B; other site 1146883012166 D-loop; other site 1146883012167 H-loop/switch region; other site 1146883012168 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1146883012169 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1146883012170 ligand binding site [chemical binding]; other site 1146883012171 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1146883012172 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1146883012173 substrate binding site [chemical binding]; other site 1146883012174 ATP binding site [chemical binding]; other site 1146883012175 BtpA family; Region: BtpA; cl00440 1146883012176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1146883012177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1146883012178 DNA binding site [nucleotide binding] 1146883012179 domain linker motif; other site 1146883012180 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1146883012181 dimerization interface [polypeptide binding]; other site 1146883012182 ligand binding site [chemical binding]; other site 1146883012183 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1146883012184 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1146883012185 metal binding site [ion binding]; metal-binding site 1146883012186 dimer interface [polypeptide binding]; other site 1146883012187 phosphoglucomutase; Validated; Region: PRK07564 1146883012188 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1146883012189 active site 1146883012190 substrate binding site [chemical binding]; other site 1146883012191 metal binding site [ion binding]; metal-binding site 1146883012192 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1146883012193 active site 1146883012194 substrate binding sites [chemical binding]; other site 1146883012195 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1146883012196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1146883012197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1146883012198 Helix-turn-helix domain; Region: HTH_18; pfam12833 1146883012199 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1146883012200 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1146883012201 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1146883012202 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1146883012203 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1146883012204 active site 1146883012205 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1146883012206 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1146883012207 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1146883012208 Restriction endonuclease; Region: Mrr_cat; pfam04471 1146883012209 potential frameshift: common BLAST hit: gi|119869881|ref|YP_939833.1| restriction endonuclease S subunits-like protein 1146883012210 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1146883012211 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1146883012212 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1146883012213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1146883012214 ATP binding site [chemical binding]; other site 1146883012215 putative Mg++ binding site [ion binding]; other site 1146883012216 hypothetical protein; Provisional; Region: PRK02237 1146883012217 PGAP1-like protein; Region: PGAP1; pfam07819 1146883012218 acyl-CoA esterase; Provisional; Region: PRK10673 1146883012219 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1146883012220 LGFP repeat; Region: LGFP; pfam08310 1146883012221 LGFP repeat; Region: LGFP; pfam08310 1146883012222 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1146883012223 Helicase_C-like; Region: Helicase_C_4; pfam13871 1146883012224 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1146883012225 RNA binding site [nucleotide binding]; other site 1146883012226 DNA polymerase IV; Provisional; Region: PRK03348 1146883012227 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1146883012228 active site 1146883012229 DNA binding site [nucleotide binding] 1146883012230 FAD binding domain; Region: FAD_binding_4; pfam01565 1146883012231 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1146883012232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1146883012233 S-adenosylmethionine binding site [chemical binding]; other site 1146883012234 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1146883012235 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1146883012236 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1146883012237 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1146883012238 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1146883012239 FAD binding pocket [chemical binding]; other site 1146883012240 FAD binding motif [chemical binding]; other site 1146883012241 phosphate binding motif [ion binding]; other site 1146883012242 beta-alpha-beta structure motif; other site 1146883012243 NAD binding pocket [chemical binding]; other site 1146883012244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1146883012245 catalytic loop [active] 1146883012246 iron binding site [ion binding]; other site 1146883012247 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1146883012248 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1146883012249 putative di-iron ligands [ion binding]; other site 1146883012250 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1146883012251 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1146883012252 Walker A motif; other site 1146883012253 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1146883012254 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1146883012255 replicative DNA helicase; Region: DnaB; TIGR00665 1146883012256 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1146883012257 ATP binding site [chemical binding]; other site 1146883012258 Walker B motif; other site 1146883012259 DNA binding loops [nucleotide binding] 1146883012260 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1146883012261 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1146883012262 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1146883012263 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1146883012264 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1146883012265 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1146883012266 dimer interface [polypeptide binding]; other site 1146883012267 ssDNA binding site [nucleotide binding]; other site 1146883012268 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1146883012269 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1146883012270 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1146883012271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1146883012272 Walker A motif; other site 1146883012273 ATP binding site [chemical binding]; other site 1146883012274 Walker B motif; other site 1146883012275 Integrase core domain; Region: rve; pfam00665 1146883012276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1146883012277 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1146883012278 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1146883012279 endonuclease IV; Provisional; Region: PRK01060 1146883012280 AP (apurinic/apyrimidinic) site pocket; other site 1146883012281 DNA interaction; other site 1146883012282 Metal-binding active site; metal-binding site 1146883012283 Predicted integral membrane protein [Function unknown]; Region: COG5650 1146883012284 Transglycosylase; Region: Transgly; pfam00912 1146883012285 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1146883012286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1146883012287 Predicted transcriptional regulators [Transcription]; Region: COG1695 1146883012288 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1146883012289 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1146883012290 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1146883012291 hypothetical protein; Validated; Region: PRK00228 1146883012292 H+ Antiporter protein; Region: 2A0121; TIGR00900 1146883012293 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1146883012294 active site 1146883012295 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1146883012296 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1146883012297 active site 1146883012298 NTP binding site [chemical binding]; other site 1146883012299 metal binding triad [ion binding]; metal-binding site 1146883012300 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1146883012301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1146883012302 Zn2+ binding site [ion binding]; other site 1146883012303 Mg2+ binding site [ion binding]; other site 1146883012304 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1146883012305 active site 1146883012306 Ap6A binding site [chemical binding]; other site 1146883012307 nudix motif; other site 1146883012308 metal binding site [ion binding]; metal-binding site 1146883012309 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1146883012310 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1146883012311 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1146883012312 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1146883012313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1146883012314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1146883012315 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1146883012316 catalytic residues [active] 1146883012317 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1146883012318 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1146883012319 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1146883012320 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1146883012321 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1146883012322 active site 1146883012323 metal binding site [ion binding]; metal-binding site 1146883012324 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1146883012325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1146883012326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1146883012327 homodimer interface [polypeptide binding]; other site 1146883012328 catalytic residue [active] 1146883012329 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1146883012330 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1146883012331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1146883012332 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1146883012333 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1146883012334 DNA binding residues [nucleotide binding] 1146883012335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1146883012336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1146883012337 Mg2+ binding site [ion binding]; other site 1146883012338 G-X-G motif; other site 1146883012339 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 1146883012340 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1146883012341 ParB-like nuclease domain; Region: ParBc; pfam02195 1146883012342 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1146883012343 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1146883012344 P-loop; other site 1146883012345 Magnesium ion binding site [ion binding]; other site 1146883012346 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1146883012347 Magnesium ion binding site [ion binding]; other site 1146883012348 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1146883012349 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1146883012350 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1146883012351 G-X-X-G motif; other site 1146883012352 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1146883012353 RxxxH motif; other site 1146883012354 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1146883012355 Haemolytic domain; Region: Haemolytic; pfam01809 1146883012356 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1146883012357 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399