-- dump date 20140619_002626 -- class Genbank::misc_feature -- table misc_feature_note -- id note 205913000001 Initiator Replication protein; Region: Rep_3; pfam01051 205913000002 MobA/MobL family; Region: MobA_MobL; pfam03389 205913000003 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 205913000004 MobA/MobL family; Region: MobA_MobL; pfam03389 205913000005 Initiator Replication protein; Region: Rep_3; pfam01051 205913000006 Replicase family; Region: Replicase; pfam03090 205913000007 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 205913000008 MobA/MobL family; Region: MobA_MobL; pfam03389 205913000009 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205913000010 DNA-binding site [nucleotide binding]; DNA binding site 205913000011 RNA-binding motif; other site 205913000012 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 205913000013 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 205913000014 ring oligomerisation interface [polypeptide binding]; other site 205913000015 ATP/Mg binding site [chemical binding]; other site 205913000016 stacking interactions; other site 205913000017 hinge regions; other site 205913000018 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 205913000019 Repair protein; Region: Repair_PSII; cl01535 205913000020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913000021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913000022 active site 205913000023 phosphorylation site [posttranslational modification] 205913000024 intermolecular recognition site; other site 205913000025 dimerization interface [polypeptide binding]; other site 205913000026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205913000027 DNA binding site [nucleotide binding] 205913000028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205913000029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205913000030 dimerization interface [polypeptide binding]; other site 205913000031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205913000032 dimer interface [polypeptide binding]; other site 205913000033 phosphorylation site [posttranslational modification] 205913000034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913000035 ATP binding site [chemical binding]; other site 205913000036 Mg2+ binding site [ion binding]; other site 205913000037 G-X-G motif; other site 205913000038 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 205913000039 DNA-binding site [nucleotide binding]; DNA binding site 205913000040 RNA-binding motif; other site 205913000041 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 205913000042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913000043 Ligand Binding Site [chemical binding]; other site 205913000044 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913000045 Ligand Binding Site [chemical binding]; other site 205913000046 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 205913000047 Clp amino terminal domain; Region: Clp_N; pfam02861 205913000048 Clp amino terminal domain; Region: Clp_N; pfam02861 205913000049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913000050 Walker A motif; other site 205913000051 ATP binding site [chemical binding]; other site 205913000052 Walker B motif; other site 205913000053 arginine finger; other site 205913000054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913000055 Walker A motif; other site 205913000056 ATP binding site [chemical binding]; other site 205913000057 Walker B motif; other site 205913000058 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205913000059 cytosine deaminase; Provisional; Region: PRK09230 205913000060 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 205913000061 active site 205913000062 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 205913000063 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 205913000064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000065 metabolite-proton symporter; Region: 2A0106; TIGR00883 205913000066 putative substrate translocation pore; other site 205913000067 Creatinine amidohydrolase; Region: Creatininase; pfam02633 205913000068 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 205913000069 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913000070 active site 205913000071 metal binding site [ion binding]; metal-binding site 205913000072 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 205913000073 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 205913000074 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 205913000075 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 205913000076 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 205913000077 dimer interface [polypeptide binding]; other site 205913000078 motif 1; other site 205913000079 active site 205913000080 motif 2; other site 205913000081 motif 3; other site 205913000082 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 205913000083 anticodon binding site; other site 205913000084 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 205913000085 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 205913000086 dimer interface [polypeptide binding]; other site 205913000087 anticodon binding site; other site 205913000088 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913000089 motif 1; other site 205913000090 dimer interface [polypeptide binding]; other site 205913000091 active site 205913000092 motif 2; other site 205913000093 GAD domain; Region: GAD; pfam02938 205913000094 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913000095 active site 205913000096 motif 3; other site 205913000097 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913000098 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205913000099 Walker A/P-loop; other site 205913000100 ATP binding site [chemical binding]; other site 205913000101 Q-loop/lid; other site 205913000102 ABC transporter signature motif; other site 205913000103 Walker B; other site 205913000104 D-loop; other site 205913000105 H-loop/switch region; other site 205913000106 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205913000107 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913000108 substrate binding pocket [chemical binding]; other site 205913000109 membrane-bound complex binding site; other site 205913000110 hinge residues; other site 205913000111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000112 dimer interface [polypeptide binding]; other site 205913000113 conserved gate region; other site 205913000114 ABC-ATPase subunit interface; other site 205913000115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000116 dimer interface [polypeptide binding]; other site 205913000117 conserved gate region; other site 205913000118 putative PBP binding loops; other site 205913000119 ABC-ATPase subunit interface; other site 205913000120 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 205913000121 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 205913000122 active site 205913000123 Helix-turn-helix domain; Region: HTH_28; pfam13518 205913000124 Winged helix-turn helix; Region: HTH_29; pfam13551 205913000125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913000126 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913000127 Walker A motif; other site 205913000128 ATP binding site [chemical binding]; other site 205913000129 Walker B motif; other site 205913000130 arginine finger; other site 205913000131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913000132 Integrase core domain; Region: rve; pfam00665 205913000133 HTH-like domain; Region: HTH_21; pfam13276 205913000134 Integrase core domain; Region: rve; pfam00665 205913000135 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 205913000136 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913000137 active site 205913000138 DNA binding site [nucleotide binding] 205913000139 Int/Topo IB signature motif; other site 205913000140 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913000141 Int/Topo IB signature motif; other site 205913000142 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913000143 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913000144 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 205913000145 Int/Topo IB signature motif; other site 205913000146 Integrase core domain; Region: rve_2; pfam13333 205913000147 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 205913000148 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 205913000149 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 205913000150 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 205913000151 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 205913000152 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 205913000153 G1 box; other site 205913000154 putative GEF interaction site [polypeptide binding]; other site 205913000155 GTP/Mg2+ binding site [chemical binding]; other site 205913000156 Switch I region; other site 205913000157 G2 box; other site 205913000158 G3 box; other site 205913000159 Switch II region; other site 205913000160 G4 box; other site 205913000161 G5 box; other site 205913000162 Lamin Tail Domain; Region: LTD; pfam00932 205913000163 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 205913000164 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 205913000165 putative active site [active] 205913000166 putative metal binding site [ion binding]; other site 205913000167 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 205913000168 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 205913000169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913000170 ATP binding site [chemical binding]; other site 205913000171 putative Mg++ binding site [ion binding]; other site 205913000172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913000173 nucleotide binding region [chemical binding]; other site 205913000174 ATP-binding site [chemical binding]; other site 205913000175 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 205913000176 recombination factor protein RarA; Reviewed; Region: PRK13342 205913000177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913000178 Walker A motif; other site 205913000179 ATP binding site [chemical binding]; other site 205913000180 Walker B motif; other site 205913000181 arginine finger; other site 205913000182 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 205913000183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913000184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913000185 active site 205913000186 phosphorylation site [posttranslational modification] 205913000187 intermolecular recognition site; other site 205913000188 dimerization interface [polypeptide binding]; other site 205913000189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205913000190 DNA binding site [nucleotide binding] 205913000191 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 205913000192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205913000193 dimerization interface [polypeptide binding]; other site 205913000194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205913000195 dimer interface [polypeptide binding]; other site 205913000196 phosphorylation site [posttranslational modification] 205913000197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913000198 ATP binding site [chemical binding]; other site 205913000199 Mg2+ binding site [ion binding]; other site 205913000200 G-X-G motif; other site 205913000201 lipoprotein LpqB; Provisional; Region: PRK13613 205913000202 Sporulation and spore germination; Region: Germane; pfam10646 205913000203 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913000204 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 205913000205 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205913000206 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205913000207 Walker A/P-loop; other site 205913000208 ATP binding site [chemical binding]; other site 205913000209 Q-loop/lid; other site 205913000210 ABC transporter signature motif; other site 205913000211 Walker B; other site 205913000212 D-loop; other site 205913000213 H-loop/switch region; other site 205913000214 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205913000215 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913000216 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205913000217 TM-ABC transporter signature motif; other site 205913000218 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913000219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205913000220 TM-ABC transporter signature motif; other site 205913000221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000222 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913000223 putative substrate translocation pore; other site 205913000224 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 205913000225 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205913000226 NAD binding site [chemical binding]; other site 205913000227 ligand binding site [chemical binding]; other site 205913000228 catalytic site [active] 205913000229 Membrane protein of unknown function; Region: DUF360; pfam04020 205913000230 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 205913000231 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 205913000232 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205913000233 Walker A/P-loop; other site 205913000234 ATP binding site [chemical binding]; other site 205913000235 Q-loop/lid; other site 205913000236 ABC transporter signature motif; other site 205913000237 Walker B; other site 205913000238 D-loop; other site 205913000239 H-loop/switch region; other site 205913000240 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 205913000241 Walker A/P-loop; other site 205913000242 ATP binding site [chemical binding]; other site 205913000243 Q-loop/lid; other site 205913000244 ABC transporter signature motif; other site 205913000245 Walker B; other site 205913000246 D-loop; other site 205913000247 H-loop/switch region; other site 205913000248 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 205913000249 Predicted membrane protein [Function unknown]; Region: COG3601 205913000250 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 205913000251 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913000252 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 205913000253 Probable Catalytic site; other site 205913000254 Helix-turn-helix domain; Region: HTH_38; pfam13936 205913000255 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913000256 Integrase core domain; Region: rve; pfam00665 205913000257 Nitroreductase family; Region: Nitroreductase; pfam00881 205913000258 FMN binding site [chemical binding]; other site 205913000259 dimer interface [polypeptide binding]; other site 205913000260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913000261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205913000262 nucleotide binding site [chemical binding]; other site 205913000263 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 205913000264 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913000266 homodimer interface [polypeptide binding]; other site 205913000267 catalytic residue [active] 205913000268 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205913000269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913000270 Walker A/P-loop; other site 205913000271 ATP binding site [chemical binding]; other site 205913000272 ABC transporter signature motif; other site 205913000273 Walker B; other site 205913000274 D-loop; other site 205913000275 H-loop/switch region; other site 205913000276 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 205913000277 TPR repeat; Region: TPR_11; pfam13414 205913000278 Ligase N family; Region: LIGANc; smart00532 205913000279 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 205913000280 nucleotide binding pocket [chemical binding]; other site 205913000281 K-X-D-G motif; other site 205913000282 catalytic site [active] 205913000283 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 205913000284 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 205913000285 Helix-hairpin-helix motif; Region: HHH; pfam00633 205913000286 helix-hairpin-helix signature motif; other site 205913000287 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 205913000288 Dimer interface [polypeptide binding]; other site 205913000289 Domain of unknown function DUF59; Region: DUF59; cl00941 205913000290 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 205913000291 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 205913000292 Walker A motif; other site 205913000293 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913000294 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913000295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000296 dimer interface [polypeptide binding]; other site 205913000297 conserved gate region; other site 205913000298 putative PBP binding loops; other site 205913000299 ABC-ATPase subunit interface; other site 205913000300 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 205913000301 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 205913000302 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 205913000303 putative active site [active] 205913000304 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 205913000305 putative alpha-glucosidase; Provisional; Region: PRK10658 205913000306 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 205913000307 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 205913000308 active site 205913000309 catalytic site [active] 205913000310 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 205913000311 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 205913000312 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 205913000313 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 205913000314 catalytic residues [active] 205913000315 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 205913000316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913000317 S-adenosylmethionine binding site [chemical binding]; other site 205913000318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205913000319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 205913000320 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 205913000321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913000322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913000323 Walker A/P-loop; other site 205913000324 ATP binding site [chemical binding]; other site 205913000325 Q-loop/lid; other site 205913000326 ABC transporter signature motif; other site 205913000327 Walker B; other site 205913000328 D-loop; other site 205913000329 H-loop/switch region; other site 205913000330 elongation factor P; Validated; Region: PRK00529 205913000331 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 205913000332 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 205913000333 RNA binding site [nucleotide binding]; other site 205913000334 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 205913000335 RNA binding site [nucleotide binding]; other site 205913000336 transcription antitermination factor NusB; Region: nusB; TIGR01951 205913000337 putative RNA binding site [nucleotide binding]; other site 205913000338 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 205913000339 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 205913000340 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 205913000341 catalytic site [active] 205913000342 subunit interface [polypeptide binding]; other site 205913000343 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 205913000344 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205913000345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205913000346 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 205913000347 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205913000348 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205913000349 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 205913000350 IMP binding site; other site 205913000351 dimer interface [polypeptide binding]; other site 205913000352 interdomain contacts; other site 205913000353 partial ornithine binding site; other site 205913000354 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 205913000355 active site 205913000356 dimer interface [polypeptide binding]; other site 205913000357 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 205913000358 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 205913000359 catalytic site [active] 205913000360 G-X2-G-X-G-K; other site 205913000361 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 205913000362 active site 205913000363 catalytic site [active] 205913000364 substrate binding site [chemical binding]; other site 205913000365 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 205913000366 translation elongation factor EF-G; Region: EF-G; TIGR00484 205913000367 G1 box; other site 205913000368 putative GEF interaction site [polypeptide binding]; other site 205913000369 GTP/Mg2+ binding site [chemical binding]; other site 205913000370 Switch I region; other site 205913000371 G2 box; other site 205913000372 G3 box; other site 205913000373 Switch II region; other site 205913000374 G4 box; other site 205913000375 G5 box; other site 205913000376 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 205913000377 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 205913000378 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 205913000379 Predicted esterase [General function prediction only]; Region: COG0400 205913000380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000382 dimer interface [polypeptide binding]; other site 205913000383 conserved gate region; other site 205913000384 putative PBP binding loops; other site 205913000385 ABC-ATPase subunit interface; other site 205913000386 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 205913000387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000388 dimer interface [polypeptide binding]; other site 205913000389 conserved gate region; other site 205913000390 putative PBP binding loops; other site 205913000391 ABC-ATPase subunit interface; other site 205913000392 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205913000393 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913000394 Walker A/P-loop; other site 205913000395 ATP binding site [chemical binding]; other site 205913000396 Q-loop/lid; other site 205913000397 ABC transporter signature motif; other site 205913000398 Walker B; other site 205913000399 D-loop; other site 205913000400 H-loop/switch region; other site 205913000401 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205913000402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205913000403 substrate binding pocket [chemical binding]; other site 205913000404 membrane-bound complex binding site; other site 205913000405 hinge residues; other site 205913000406 hypothetical protein; Provisional; Region: PRK05939 205913000407 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205913000408 homodimer interface [polypeptide binding]; other site 205913000409 substrate-cofactor binding pocket; other site 205913000410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913000411 catalytic residue [active] 205913000412 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 205913000413 catalytic residues [active] 205913000414 Predicted transcriptional regulator [Transcription]; Region: COG1959 205913000415 Transcriptional regulator; Region: Rrf2; pfam02082 205913000416 Zinc-binding dehydrogenase; Region: ADH_zinc_N_2; pfam13602 205913000417 NIL domain; Region: NIL; pfam09383 205913000418 methionine gamma-lyase; Provisional; Region: PRK07503 205913000419 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913000420 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 205913000421 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205913000422 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 205913000423 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 205913000424 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 205913000425 active site 205913000426 nucleophile elbow; other site 205913000427 glutamate racemase; Provisional; Region: PRK00865 205913000428 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 205913000429 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205913000430 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 205913000431 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 205913000432 putative active site [active] 205913000433 redox center [active] 205913000434 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 205913000435 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 205913000436 active site 205913000437 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 205913000438 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 205913000439 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 205913000440 substrate binding site [chemical binding]; other site 205913000441 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205913000442 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205913000443 Family description; Region: UvrD_C_2; pfam13538 205913000444 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 205913000445 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 205913000446 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 205913000447 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 205913000448 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 205913000449 DivIVA domain; Region: DivI1A_domain; TIGR03544 205913000450 DivIVA domain; Region: DivI1A_domain; TIGR03544 205913000451 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 205913000452 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 205913000453 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 205913000454 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 205913000455 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 205913000456 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205913000457 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 205913000458 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205913000459 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 205913000460 Recombination protein O N terminal; Region: RecO_N; pfam11967 205913000461 Recombination protein O C terminal; Region: RecO_C; pfam02565 205913000462 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 205913000463 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 205913000464 catalytic residue [active] 205913000465 putative FPP diphosphate binding site; other site 205913000466 putative FPP binding hydrophobic cleft; other site 205913000467 dimer interface [polypeptide binding]; other site 205913000468 putative IPP diphosphate binding site; other site 205913000469 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 205913000470 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 205913000471 active site 205913000472 NMT1/THI5 like; Region: NMT1; pfam09084 205913000473 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 205913000474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000475 dimer interface [polypeptide binding]; other site 205913000476 conserved gate region; other site 205913000477 putative PBP binding loops; other site 205913000478 ABC-ATPase subunit interface; other site 205913000479 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 205913000480 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 205913000481 substrate binding [chemical binding]; other site 205913000482 active site 205913000483 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 205913000484 galactoside permease; Reviewed; Region: lacY; PRK09528 205913000485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000486 putative substrate translocation pore; other site 205913000487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913000488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913000489 DNA binding site [nucleotide binding] 205913000490 domain linker motif; other site 205913000491 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 205913000492 putative dimerization interface [polypeptide binding]; other site 205913000493 putative ligand binding site [chemical binding]; other site 205913000494 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 205913000495 serpin-like protein; Provisional; Region: PHA02660 205913000496 reactive center loop; other site 205913000497 benzoate transport; Region: 2A0115; TIGR00895 205913000498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000499 putative substrate translocation pore; other site 205913000500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000501 putative substrate translocation pore; other site 205913000502 Domain of unknown function DUF77; Region: DUF77; pfam01910 205913000503 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 205913000504 substrate binding site [chemical binding]; other site 205913000505 dimer interface [polypeptide binding]; other site 205913000506 ATP binding site [chemical binding]; other site 205913000507 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 205913000508 thiamine phosphate binding site [chemical binding]; other site 205913000509 active site 205913000510 pyrophosphate binding site [ion binding]; other site 205913000511 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 205913000512 ThiC-associated domain; Region: ThiC-associated; pfam13667 205913000513 ThiC family; Region: ThiC; pfam01964 205913000514 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 205913000515 substrate binding site [chemical binding]; other site 205913000516 multimerization interface [polypeptide binding]; other site 205913000517 ATP binding site [chemical binding]; other site 205913000518 glycyl-tRNA synthetase; Provisional; Region: PRK04173 205913000519 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913000520 motif 1; other site 205913000521 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 205913000522 active site 205913000523 motif 2; other site 205913000524 motif 3; other site 205913000525 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 205913000526 anticodon binding site; other site 205913000527 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 205913000528 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 205913000529 FMN binding site [chemical binding]; other site 205913000530 active site 205913000531 catalytic residues [active] 205913000532 substrate binding site [chemical binding]; other site 205913000533 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 205913000534 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 205913000535 nucleotide binding site [chemical binding]; other site 205913000536 SulA interaction site; other site 205913000537 Protein of unknown function (DUF552); Region: DUF552; pfam04472 205913000538 YGGT family; Region: YGGT; pfam02325 205913000539 DivIVA protein; Region: DivIVA; pfam05103 205913000540 DivIVA domain; Region: DivI1A_domain; TIGR03544 205913000541 lipoprotein signal peptidase; Provisional; Region: PRK14771 205913000542 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205913000543 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 205913000544 active site 205913000545 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913000546 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 205913000547 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 205913000548 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 205913000549 active site 205913000550 PHP Thumb interface [polypeptide binding]; other site 205913000551 metal binding site [ion binding]; metal-binding site 205913000552 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 205913000553 generic binding surface II; other site 205913000554 generic binding surface I; other site 205913000555 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 205913000556 myosin-cross-reactive antigen; Provisional; Region: PRK13977 205913000557 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205913000558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913000559 Coenzyme A binding pocket [chemical binding]; other site 205913000560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913000561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913000562 active site 205913000563 catalytic tetrad [active] 205913000564 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 205913000565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913000566 nucleotide binding site [chemical binding]; other site 205913000567 acylphosphatase; Provisional; Region: PRK14428 205913000568 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 205913000569 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 205913000570 NAD binding site [chemical binding]; other site 205913000571 dimerization interface [polypeptide binding]; other site 205913000572 product binding site; other site 205913000573 substrate binding site [chemical binding]; other site 205913000574 zinc binding site [ion binding]; other site 205913000575 catalytic residues [active] 205913000576 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 205913000577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913000578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913000579 homodimer interface [polypeptide binding]; other site 205913000580 catalytic residue [active] 205913000581 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 205913000582 putative active site pocket [active] 205913000583 4-fold oligomerization interface [polypeptide binding]; other site 205913000584 metal binding residues [ion binding]; metal-binding site 205913000585 3-fold/trimer interface [polypeptide binding]; other site 205913000586 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 205913000587 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 205913000588 putative active site [active] 205913000589 oxyanion strand; other site 205913000590 catalytic triad [active] 205913000591 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 205913000592 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 205913000593 catalytic residues [active] 205913000594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 205913000595 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 205913000596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 205913000597 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 205913000598 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205913000599 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205913000600 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205913000601 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 205913000602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913000603 ATP binding site [chemical binding]; other site 205913000604 putative Mg++ binding site [ion binding]; other site 205913000605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913000606 nucleotide binding region [chemical binding]; other site 205913000607 ATP-binding site [chemical binding]; other site 205913000608 Helicase associated domain (HA2); Region: HA2; pfam04408 205913000609 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 205913000610 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 205913000611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913000612 S-adenosylmethionine binding site [chemical binding]; other site 205913000613 GTPases [General function prediction only]; Region: HflX; COG2262 205913000614 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 205913000615 HflX GTPase family; Region: HflX; cd01878 205913000616 G1 box; other site 205913000617 GTP/Mg2+ binding site [chemical binding]; other site 205913000618 Switch I region; other site 205913000619 G2 box; other site 205913000620 G3 box; other site 205913000621 Switch II region; other site 205913000622 G4 box; other site 205913000623 G5 box; other site 205913000624 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 205913000625 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 205913000626 NAD binding site [chemical binding]; other site 205913000627 dimer interface [polypeptide binding]; other site 205913000628 substrate binding site [chemical binding]; other site 205913000629 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913000630 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 205913000631 LexA repressor; Validated; Region: PRK00215 205913000632 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 205913000633 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205913000634 Catalytic site [active] 205913000635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205913000636 ATP cone domain; Region: ATP-cone; pfam03477 205913000637 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 205913000638 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 205913000639 ligand binding site [chemical binding]; other site 205913000640 NAD binding site [chemical binding]; other site 205913000641 tetramer interface [polypeptide binding]; other site 205913000642 catalytic site [active] 205913000643 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 205913000644 L-serine binding site [chemical binding]; other site 205913000645 ACT domain interface; other site 205913000646 Part of AAA domain; Region: AAA_19; pfam13245 205913000647 Family description; Region: UvrD_C_2; pfam13538 205913000648 cell division protein MraZ; Reviewed; Region: PRK00326 205913000649 MraZ protein; Region: MraZ; pfam02381 205913000650 MraZ protein; Region: MraZ; pfam02381 205913000651 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 205913000652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913000653 S-adenosylmethionine binding site [chemical binding]; other site 205913000654 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 205913000655 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 205913000656 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 205913000657 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 205913000658 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 205913000659 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205913000660 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000661 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000662 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 205913000663 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 205913000664 Mg++ binding site [ion binding]; other site 205913000665 putative catalytic motif [active] 205913000666 putative substrate binding site [chemical binding]; other site 205913000667 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 205913000668 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 205913000669 NAD binding site [chemical binding]; other site 205913000670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000672 cell division protein FtsW; Region: ftsW; TIGR02614 205913000673 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 205913000674 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 205913000675 active site 205913000676 homodimer interface [polypeptide binding]; other site 205913000677 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 205913000678 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205913000679 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000681 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 205913000682 Cell division protein FtsQ; Region: FtsQ; pfam03799 205913000683 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 205913000684 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 205913000685 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 205913000686 putative active site [active] 205913000687 dimerization interface [polypeptide binding]; other site 205913000688 putative tRNAtyr binding site [nucleotide binding]; other site 205913000689 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 205913000690 active site 205913000691 catalytic site [active] 205913000692 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 205913000693 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 205913000694 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 205913000695 active site 205913000696 catalytic site [active] 205913000697 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 205913000698 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 205913000699 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 205913000700 active site 205913000701 catalytic site [active] 205913000702 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 205913000703 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 205913000704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913000705 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913000706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000707 dimer interface [polypeptide binding]; other site 205913000708 conserved gate region; other site 205913000709 putative PBP binding loops; other site 205913000710 ABC-ATPase subunit interface; other site 205913000711 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913000712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000713 putative PBP binding loops; other site 205913000714 dimer interface [polypeptide binding]; other site 205913000715 ABC-ATPase subunit interface; other site 205913000716 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 205913000717 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 205913000718 putative active site [active] 205913000719 putative catalytic site [active] 205913000720 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 205913000721 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 205913000722 putative active site [active] 205913000723 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 205913000724 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 205913000725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913000726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913000727 DNA binding site [nucleotide binding] 205913000728 domain linker motif; other site 205913000729 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913000730 ligand binding site [chemical binding]; other site 205913000731 dimerization interface [polypeptide binding]; other site 205913000732 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 205913000733 putative active cleft [active] 205913000734 Uncharacterized conserved protein [Function unknown]; Region: COG3538 205913000735 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 205913000736 L-fucose transporter; Provisional; Region: PRK10133; cl17665 205913000737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205913000738 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 205913000739 active site 205913000740 metal binding site [ion binding]; metal-binding site 205913000741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205913000742 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 205913000743 putative substrate binding site [chemical binding]; other site 205913000744 putative ATP binding site [chemical binding]; other site 205913000745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205913000746 putative DNA binding site [nucleotide binding]; other site 205913000747 Transcriptional regulators [Transcription]; Region: MarR; COG1846 205913000748 putative Zn2+ binding site [ion binding]; other site 205913000749 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913000750 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913000751 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913000752 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205913000753 nucleotide binding site [chemical binding]; other site 205913000754 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 205913000755 non-specific DNA interactions [nucleotide binding]; other site 205913000756 DNA binding site [nucleotide binding] 205913000757 sequence specific DNA binding site [nucleotide binding]; other site 205913000758 putative cAMP binding site [chemical binding]; other site 205913000759 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913000760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205913000761 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 205913000762 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 205913000763 active site 205913000764 trimer interface [polypeptide binding]; other site 205913000765 allosteric site; other site 205913000766 active site lid [active] 205913000767 hexamer (dimer of trimers) interface [polypeptide binding]; other site 205913000768 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 205913000769 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 205913000770 active site 205913000771 dimer interface [polypeptide binding]; other site 205913000772 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205913000773 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 205913000774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205913000775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000776 dimer interface [polypeptide binding]; other site 205913000777 conserved gate region; other site 205913000778 putative PBP binding loops; other site 205913000779 ABC-ATPase subunit interface; other site 205913000780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205913000781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000782 dimer interface [polypeptide binding]; other site 205913000783 conserved gate region; other site 205913000784 ABC-ATPase subunit interface; other site 205913000785 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 205913000786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913000787 Walker A/P-loop; other site 205913000788 ATP binding site [chemical binding]; other site 205913000789 Q-loop/lid; other site 205913000790 ABC transporter signature motif; other site 205913000791 Walker B; other site 205913000792 D-loop; other site 205913000793 H-loop/switch region; other site 205913000794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913000796 Walker A/P-loop; other site 205913000797 ATP binding site [chemical binding]; other site 205913000798 Q-loop/lid; other site 205913000799 ABC transporter signature motif; other site 205913000800 Walker B; other site 205913000801 D-loop; other site 205913000802 H-loop/switch region; other site 205913000803 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000804 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 205913000805 nudix motif; other site 205913000806 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 205913000807 proline aminopeptidase P II; Provisional; Region: PRK10879 205913000808 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 205913000809 active site 205913000810 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 205913000811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000812 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000813 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 205913000814 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 205913000815 Walker A/P-loop; other site 205913000816 ATP binding site [chemical binding]; other site 205913000817 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 205913000818 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 205913000819 ABC transporter signature motif; other site 205913000820 Walker B; other site 205913000821 D-loop; other site 205913000822 H-loop/switch region; other site 205913000823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 205913000824 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 205913000825 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 205913000826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913000827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 205913000828 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 205913000829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205913000830 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205913000831 DNA binding residues [nucleotide binding] 205913000832 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 205913000833 active site 205913000834 catalytic residues [active] 205913000835 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 205913000836 active site 205913000837 catalytic residues [active] 205913000838 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 205913000839 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 205913000840 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 205913000841 putative deacylase active site [active] 205913000842 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 205913000843 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 205913000844 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205913000845 Thiamine pyrophosphokinase; Region: TPK; cd07995 205913000846 active site 205913000847 dimerization interface [polypeptide binding]; other site 205913000848 thiamine binding site [chemical binding]; other site 205913000849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913000850 S-adenosylmethionine binding site [chemical binding]; other site 205913000851 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 205913000852 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 205913000853 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 205913000854 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 205913000855 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 205913000856 23S rRNA binding site [nucleotide binding]; other site 205913000857 L21 binding site [polypeptide binding]; other site 205913000858 L13 binding site [polypeptide binding]; other site 205913000859 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 205913000860 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 205913000861 active site 205913000862 Int/Topo IB signature motif; other site 205913000863 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913000864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913000865 Walker A/P-loop; other site 205913000866 ATP binding site [chemical binding]; other site 205913000867 Q-loop/lid; other site 205913000868 ABC transporter signature motif; other site 205913000869 Walker B; other site 205913000870 D-loop; other site 205913000871 H-loop/switch region; other site 205913000872 FtsX-like permease family; Region: FtsX; pfam02687 205913000873 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913000874 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913000875 P-loop; other site 205913000876 Magnesium ion binding site [ion binding]; other site 205913000877 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913000878 Magnesium ion binding site [ion binding]; other site 205913000879 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 205913000880 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 205913000881 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 205913000882 nudix motif; other site 205913000883 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 205913000884 quinolinate synthetase; Provisional; Region: PRK09375 205913000885 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 205913000886 L-aspartate oxidase; Provisional; Region: PRK06175 205913000887 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205913000888 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 205913000889 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 205913000890 dimerization interface [polypeptide binding]; other site 205913000891 active site 205913000892 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 205913000893 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 205913000894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913000895 catalytic residue [active] 205913000896 benzoate transport; Region: 2A0115; TIGR00895 205913000897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913000898 putative substrate translocation pore; other site 205913000899 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 205913000900 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 205913000901 G1 box; other site 205913000902 putative GEF interaction site [polypeptide binding]; other site 205913000903 GTP/Mg2+ binding site [chemical binding]; other site 205913000904 Switch I region; other site 205913000905 G2 box; other site 205913000906 G3 box; other site 205913000907 Switch II region; other site 205913000908 G4 box; other site 205913000909 G5 box; other site 205913000910 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 205913000911 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 205913000912 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 205913000913 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 205913000914 Prephenate dehydratase; Region: PDT; pfam00800 205913000915 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 205913000916 putative L-Phe binding site [chemical binding]; other site 205913000917 Prephenate dehydrogenase; Region: PDH; pfam02153 205913000918 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 205913000919 prephenate dehydrogenase; Validated; Region: PRK08507 205913000920 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913000921 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913000922 active site 205913000923 DNA binding site [nucleotide binding] 205913000924 Int/Topo IB signature motif; other site 205913000925 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 205913000926 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913000927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205913000928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000929 dimer interface [polypeptide binding]; other site 205913000930 conserved gate region; other site 205913000931 putative PBP binding loops; other site 205913000932 ABC-ATPase subunit interface; other site 205913000933 Helix-turn-helix domain; Region: HTH_38; pfam13936 205913000934 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913000935 Integrase core domain; Region: rve; pfam00665 205913000936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 205913000937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913000938 dimer interface [polypeptide binding]; other site 205913000939 conserved gate region; other site 205913000940 putative PBP binding loops; other site 205913000941 ABC-ATPase subunit interface; other site 205913000942 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913000943 AAA domain; Region: AAA_21; pfam13304 205913000944 Walker A/P-loop; other site 205913000945 ATP binding site [chemical binding]; other site 205913000946 Q-loop/lid; other site 205913000947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913000948 ABC transporter signature motif; other site 205913000949 Walker B; other site 205913000950 D-loop; other site 205913000951 H-loop/switch region; other site 205913000952 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913000954 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 205913000955 Walker A/P-loop; other site 205913000956 ATP binding site [chemical binding]; other site 205913000957 Q-loop/lid; other site 205913000958 ABC transporter signature motif; other site 205913000959 Walker B; other site 205913000960 D-loop; other site 205913000961 H-loop/switch region; other site 205913000962 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913000963 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 205913000964 putative active site [active] 205913000965 putative catalytic site [active] 205913000966 putative DNA binding site [nucleotide binding]; other site 205913000967 putative phosphate binding site [ion binding]; other site 205913000968 metal binding site A [ion binding]; metal-binding site 205913000969 putative AP binding site [nucleotide binding]; other site 205913000970 putative metal binding site B [ion binding]; other site 205913000971 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 205913000972 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 205913000973 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 205913000974 TRAM domain; Region: TRAM; cl01282 205913000975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913000976 S-adenosylmethionine binding site [chemical binding]; other site 205913000977 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913000978 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 205913000979 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913000980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913000981 motif II; other site 205913000982 aconitate hydratase; Validated; Region: PRK09277 205913000983 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 205913000984 substrate binding site [chemical binding]; other site 205913000985 ligand binding site [chemical binding]; other site 205913000986 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 205913000987 substrate binding site [chemical binding]; other site 205913000988 RelB antitoxin; Region: RelB; cl01171 205913000989 Protein of unknown function DUF262; Region: DUF262; pfam03235 205913000990 Uncharacterized conserved protein [Function unknown]; Region: COG1479 205913000991 Protein of unknown function DUF262; Region: DUF262; pfam03235 205913000992 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 205913000993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913000994 Coenzyme A binding pocket [chemical binding]; other site 205913000995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913000997 active site 205913000998 phosphorylation site [posttranslational modification] 205913000999 intermolecular recognition site; other site 205913001000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205913001001 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 205913001002 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 205913001003 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 205913001004 EamA-like transporter family; Region: EamA; pfam00892 205913001005 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205913001006 synthetase active site [active] 205913001007 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 205913001008 NTP binding site [chemical binding]; other site 205913001009 metal binding site [ion binding]; metal-binding site 205913001010 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 205913001011 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 205913001012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205913001013 FeS/SAM binding site; other site 205913001014 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 205913001015 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 205913001016 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 205913001017 Fic/DOC family; Region: Fic; cl00960 205913001018 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 205913001019 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 205913001020 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 205913001021 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 205913001022 Competence-damaged protein; Region: CinA; pfam02464 205913001023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001024 sequence-specific DNA binding site [nucleotide binding]; other site 205913001025 salt bridge; other site 205913001026 recombinase A; Provisional; Region: recA; PRK09354 205913001027 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 205913001028 hexamer interface [polypeptide binding]; other site 205913001029 Walker A motif; other site 205913001030 ATP binding site [chemical binding]; other site 205913001031 Walker B motif; other site 205913001032 RecX family; Region: RecX; pfam02631 205913001033 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 205913001034 30S subunit binding site; other site 205913001035 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 205913001036 DEAD/DEAH box helicase; Region: DEAD; pfam00270 205913001037 ATP binding site [chemical binding]; other site 205913001038 putative Mg++ binding site [ion binding]; other site 205913001039 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 205913001040 SEC-C motif; Region: SEC-C; pfam02810 205913001041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 205913001042 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205913001043 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 205913001044 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 205913001045 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 205913001046 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205913001047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205913001048 putative acyl-acceptor binding pocket; other site 205913001049 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913001050 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913001051 active site 205913001052 ATP binding site [chemical binding]; other site 205913001053 substrate binding site [chemical binding]; other site 205913001054 activation loop (A-loop); other site 205913001055 PASTA domain; Region: PASTA; pfam03793 205913001056 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 205913001057 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 205913001058 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 205913001059 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 205913001060 substrate binding pocket [chemical binding]; other site 205913001061 chain length determination region; other site 205913001062 substrate-Mg2+ binding site; other site 205913001063 catalytic residues [active] 205913001064 aspartate-rich region 1; other site 205913001065 active site lid residues [active] 205913001066 aspartate-rich region 2; other site 205913001067 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 205913001068 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 205913001069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 205913001070 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 205913001071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 205913001072 DNA binding residues [nucleotide binding] 205913001073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913001074 Mg2+ binding site [ion binding]; other site 205913001075 G-X-G motif; other site 205913001076 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205913001077 anchoring element; other site 205913001078 dimer interface [polypeptide binding]; other site 205913001079 ATP binding site [chemical binding]; other site 205913001080 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 205913001081 active site 205913001082 metal binding site [ion binding]; metal-binding site 205913001083 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205913001084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913001086 putative substrate translocation pore; other site 205913001087 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 205913001088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205913001089 substrate binding site [chemical binding]; other site 205913001090 dimer interface [polypeptide binding]; other site 205913001091 ATP binding site [chemical binding]; other site 205913001092 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205913001093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913001094 ATP binding site [chemical binding]; other site 205913001095 putative Mg++ binding site [ion binding]; other site 205913001096 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 205913001097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913001098 nucleotide binding region [chemical binding]; other site 205913001099 ATP-binding site [chemical binding]; other site 205913001100 DEAD/H associated; Region: DEAD_assoc; pfam08494 205913001101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913001102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 205913001103 phosphorylation site [posttranslational modification] 205913001104 intermolecular recognition site; other site 205913001105 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 205913001106 DNA binding site [nucleotide binding] 205913001107 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 205913001108 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 205913001109 CAP-like domain; other site 205913001110 active site 205913001111 primary dimer interface [polypeptide binding]; other site 205913001112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913001113 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 205913001114 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 205913001115 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 205913001116 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205913001117 trimer interface [polypeptide binding]; other site 205913001118 active site 205913001119 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 205913001120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205913001121 Zn2+ binding site [ion binding]; other site 205913001122 Mg2+ binding site [ion binding]; other site 205913001123 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 205913001124 synthetase active site [active] 205913001125 NTP binding site [chemical binding]; other site 205913001126 metal binding site [ion binding]; metal-binding site 205913001127 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 205913001128 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 205913001129 Integrase core domain; Region: rve; pfam00665 205913001130 Integrase core domain; Region: rve_2; pfam13333 205913001131 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 205913001132 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913001133 active site 205913001134 DNA binding site [nucleotide binding] 205913001135 Int/Topo IB signature motif; other site 205913001136 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913001137 Int/Topo IB signature motif; other site 205913001138 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913001139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913001140 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 205913001141 Int/Topo IB signature motif; other site 205913001142 Integrase core domain; Region: rve; pfam00665 205913001143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913001144 Integrase core domain; Region: rve; pfam00665 205913001145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913001146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913001147 Walker A motif; other site 205913001148 ATP binding site [chemical binding]; other site 205913001149 Walker B motif; other site 205913001150 arginine finger; other site 205913001151 HTH-like domain; Region: HTH_21; pfam13276 205913001152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205913001153 Helix-turn-helix domain; Region: HTH_28; pfam13518 205913001154 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 205913001155 active site 205913001156 EamA-like transporter family; Region: EamA; pfam00892 205913001157 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 205913001158 EamA-like transporter family; Region: EamA; pfam00892 205913001159 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 205913001160 Methyltransferase domain; Region: Methyltransf_26; pfam13659 205913001161 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001162 catalytic core [active] 205913001163 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 205913001164 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 205913001165 Cl binding site [ion binding]; other site 205913001166 oligomer interface [polypeptide binding]; other site 205913001167 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 205913001168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205913001169 substrate binding pocket [chemical binding]; other site 205913001170 membrane-bound complex binding site; other site 205913001171 hinge residues; other site 205913001172 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 205913001173 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001174 active site 205913001175 HIGH motif; other site 205913001176 nucleotide binding site [chemical binding]; other site 205913001177 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001178 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 205913001179 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001180 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913001181 active site 205913001182 KMSKS motif; other site 205913001183 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 205913001184 tRNA binding surface [nucleotide binding]; other site 205913001185 Helix-hairpin-helix motif; Region: HHH; pfam00633 205913001186 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 205913001187 Competence protein; Region: Competence; pfam03772 205913001188 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 205913001189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 205913001190 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 205913001191 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 205913001192 active site 205913001193 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 205913001194 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 205913001195 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 205913001196 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 205913001197 Glycoprotease family; Region: Peptidase_M22; pfam00814 205913001198 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 205913001199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913001200 Coenzyme A binding pocket [chemical binding]; other site 205913001201 UGMP family protein; Validated; Region: PRK09604 205913001202 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 205913001203 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913001204 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913001205 active site 205913001206 DNA binding site [nucleotide binding] 205913001207 Int/Topo IB signature motif; other site 205913001208 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 205913001209 Fic family protein [Function unknown]; Region: COG3177 205913001210 Fic/DOC family; Region: Fic; pfam02661 205913001211 Antirestriction protein (ArdA); Region: ArdA; cl01953 205913001212 CHAP domain; Region: CHAP; cl17642 205913001213 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205913001214 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205913001215 catalytic residue [active] 205913001216 DNA topoisomerase III; Provisional; Region: PRK07726 205913001217 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 205913001218 active site 205913001219 putative interdomain interaction site [polypeptide binding]; other site 205913001220 putative metal-binding site [ion binding]; other site 205913001221 putative nucleotide binding site [chemical binding]; other site 205913001222 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 205913001223 domain I; other site 205913001224 DNA binding groove [nucleotide binding] 205913001225 phosphate binding site [ion binding]; other site 205913001226 domain II; other site 205913001227 domain III; other site 205913001228 nucleotide binding site [chemical binding]; other site 205913001229 catalytic site [active] 205913001230 domain IV; other site 205913001231 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 205913001232 EcoRII C terminal; Region: EcoRII-C; pfam09019 205913001233 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205913001234 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 205913001235 cofactor binding site; other site 205913001236 DNA binding site [nucleotide binding] 205913001237 substrate interaction site [chemical binding]; other site 205913001238 Fic/DOC family; Region: Fic; cl00960 205913001239 HipA N-terminal domain; Region: Couple_hipA; cl11853 205913001240 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205913001241 HipA-like C-terminal domain; Region: HipA_C; pfam07804 205913001242 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 205913001243 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 205913001244 AAA-like domain; Region: AAA_10; pfam12846 205913001245 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 205913001246 T surface-antigen of pili; Region: FctA; pfam12892 205913001247 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 205913001248 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 205913001249 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 205913001250 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 205913001251 T surface-antigen of pili; Region: FctA; pfam12892 205913001252 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 205913001253 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 205913001254 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 205913001255 hypothetical protein; Region: PHA01623 205913001256 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913001257 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 205913001258 P-loop; other site 205913001259 Magnesium ion binding site [ion binding]; other site 205913001260 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913001261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913001262 P-loop; other site 205913001263 Magnesium ion binding site [ion binding]; other site 205913001264 Transcription factor WhiB; Region: Whib; pfam02467 205913001265 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205913001266 non-specific DNA interactions [nucleotide binding]; other site 205913001267 DNA binding site [nucleotide binding] 205913001268 sequence specific DNA binding site [nucleotide binding]; other site 205913001269 putative cAMP binding site [chemical binding]; other site 205913001270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 205913001271 non-specific DNA binding site [nucleotide binding]; other site 205913001272 salt bridge; other site 205913001273 sequence-specific DNA binding site [nucleotide binding]; other site 205913001274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001275 non-specific DNA binding site [nucleotide binding]; other site 205913001276 salt bridge; other site 205913001277 sequence-specific DNA binding site [nucleotide binding]; other site 205913001278 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 205913001279 Peptidase family M23; Region: Peptidase_M23; pfam01551 205913001280 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913001281 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913001282 isocitrate dehydrogenase; Validated; Region: PRK08299 205913001283 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 205913001284 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 205913001285 active site 205913001286 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913001287 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 205913001288 acyl-activating enzyme (AAE) consensus motif; other site 205913001289 putative AMP binding site [chemical binding]; other site 205913001290 putative active site [active] 205913001291 putative CoA binding site [chemical binding]; other site 205913001292 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205913001293 active site 205913001294 catalytic residues [active] 205913001295 metal binding site [ion binding]; metal-binding site 205913001296 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 205913001297 rRNA interaction site [nucleotide binding]; other site 205913001298 S8 interaction site; other site 205913001299 putative laminin-1 binding site; other site 205913001300 elongation factor Ts; Provisional; Region: tsf; PRK09377 205913001301 Elongation factor TS; Region: EF_TS; pfam00889 205913001302 Elongation factor TS; Region: EF_TS; pfam00889 205913001303 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 205913001304 putative nucleotide binding site [chemical binding]; other site 205913001305 uridine monophosphate binding site [chemical binding]; other site 205913001306 homohexameric interface [polypeptide binding]; other site 205913001307 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 205913001308 ribosome recycling factor; Reviewed; Region: frr; PRK00083 205913001309 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 205913001310 hinge region; other site 205913001311 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 205913001312 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 205913001313 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 205913001314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205913001315 FeS/SAM binding site; other site 205913001316 intracellular protease, PfpI family; Region: PfpI; TIGR01382 205913001317 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 205913001318 proposed catalytic triad [active] 205913001319 conserved cys residue [active] 205913001320 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 205913001321 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 205913001322 substrate binding site [chemical binding]; other site 205913001323 glutamase interaction surface [polypeptide binding]; other site 205913001324 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 205913001325 anthranilate synthase component I; Provisional; Region: PRK13571 205913001326 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 205913001327 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 205913001328 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 205913001329 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 205913001330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913001331 Walker A/P-loop; other site 205913001332 ATP binding site [chemical binding]; other site 205913001333 Q-loop/lid; other site 205913001334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205913001335 ABC transporter signature motif; other site 205913001336 Walker B; other site 205913001337 D-loop; other site 205913001338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205913001339 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 205913001340 classical (c) SDRs; Region: SDR_c; cd05233 205913001341 NAD(P) binding site [chemical binding]; other site 205913001342 active site 205913001343 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 205913001344 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205913001345 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 205913001346 Walker A/P-loop; other site 205913001347 ATP binding site [chemical binding]; other site 205913001348 Q-loop/lid; other site 205913001349 ABC transporter signature motif; other site 205913001350 Walker B; other site 205913001351 D-loop; other site 205913001352 H-loop/switch region; other site 205913001353 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 205913001354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913001355 Walker A/P-loop; other site 205913001356 ATP binding site [chemical binding]; other site 205913001357 Q-loop/lid; other site 205913001358 ABC transporter signature motif; other site 205913001359 Walker B; other site 205913001360 D-loop; other site 205913001361 H-loop/switch region; other site 205913001362 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 205913001363 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 205913001364 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 205913001365 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 205913001366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 205913001367 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 205913001368 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 205913001369 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 205913001370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 205913001371 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 205913001372 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 205913001373 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 205913001374 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 205913001375 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 205913001376 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 205913001377 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 205913001378 GIY-YIG motif/motif A; other site 205913001379 active site 205913001380 catalytic site [active] 205913001381 putative DNA binding site [nucleotide binding]; other site 205913001382 metal binding site [ion binding]; metal-binding site 205913001383 UvrB/uvrC motif; Region: UVR; pfam02151 205913001384 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 205913001385 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 205913001386 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 205913001387 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 205913001388 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 205913001389 shikimate binding site; other site 205913001390 NAD(P) binding site [chemical binding]; other site 205913001391 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 205913001392 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 205913001393 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 205913001394 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 205913001395 Phosphoglycerate kinase; Region: PGK; pfam00162 205913001396 substrate binding site [chemical binding]; other site 205913001397 hinge regions; other site 205913001398 ADP binding site [chemical binding]; other site 205913001399 catalytic site [active] 205913001400 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 205913001401 triosephosphate isomerase; Provisional; Region: PRK14567 205913001402 substrate binding site [chemical binding]; other site 205913001403 dimer interface [polypeptide binding]; other site 205913001404 catalytic triad [active] 205913001405 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 205913001406 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913001407 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 205913001408 NAD binding site [chemical binding]; other site 205913001409 dimer interface [polypeptide binding]; other site 205913001410 substrate binding site [chemical binding]; other site 205913001411 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205913001412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913001413 active site 205913001414 motif I; other site 205913001415 motif II; other site 205913001416 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 205913001417 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 205913001418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001419 non-specific DNA binding site [nucleotide binding]; other site 205913001420 salt bridge; other site 205913001421 sequence-specific DNA binding site [nucleotide binding]; other site 205913001422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913001423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913001424 homodimer interface [polypeptide binding]; other site 205913001425 catalytic residue [active] 205913001426 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 205913001427 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 205913001428 putative active site [active] 205913001429 transaldolase; Provisional; Region: PRK03903 205913001430 catalytic residue [active] 205913001431 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 205913001432 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 205913001433 TPP-binding site [chemical binding]; other site 205913001434 dimer interface [polypeptide binding]; other site 205913001435 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205913001436 PYR/PP interface [polypeptide binding]; other site 205913001437 dimer interface [polypeptide binding]; other site 205913001438 TPP binding site [chemical binding]; other site 205913001439 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205913001440 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 205913001441 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 205913001442 chaperone protein DnaJ; Provisional; Region: PRK14278 205913001443 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205913001444 HSP70 interaction site [polypeptide binding]; other site 205913001445 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 205913001446 Zn binding sites [ion binding]; other site 205913001447 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205913001448 dimer interface [polypeptide binding]; other site 205913001449 Fructosamine kinase; Region: Fructosamin_kin; cl17579 205913001450 Phosphotransferase enzyme family; Region: APH; pfam01636 205913001451 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 205913001452 PAC2 family; Region: PAC2; pfam09754 205913001453 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205913001454 thiS-thiF/thiG interaction site; other site 205913001455 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 205913001456 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 205913001457 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 205913001458 active site 205913001459 dimer interface [polypeptide binding]; other site 205913001460 motif 1; other site 205913001461 motif 2; other site 205913001462 motif 3; other site 205913001463 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 205913001464 anticodon binding site; other site 205913001465 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 205913001466 nucleotide binding site/active site [active] 205913001467 HIT family signature motif; other site 205913001468 catalytic residue [active] 205913001469 hypothetical protein; Validated; Region: PRK00110 205913001470 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 205913001471 active site 205913001472 putative DNA-binding cleft [nucleotide binding]; other site 205913001473 dimer interface [polypeptide binding]; other site 205913001474 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 205913001475 RuvA N terminal domain; Region: RuvA_N; pfam01330 205913001476 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 205913001477 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 205913001478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913001479 Walker A motif; other site 205913001480 ATP binding site [chemical binding]; other site 205913001481 Walker B motif; other site 205913001482 arginine finger; other site 205913001483 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 205913001484 Preprotein translocase subunit; Region: YajC; pfam02699 205913001485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913001486 active site 205913001487 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 205913001488 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 205913001489 CoA-ligase; Region: Ligase_CoA; pfam00549 205913001490 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 205913001491 CoA binding domain; Region: CoA_binding; smart00881 205913001492 CoA-ligase; Region: Ligase_CoA; pfam00549 205913001493 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 205913001494 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 205913001495 purine monophosphate binding site [chemical binding]; other site 205913001496 dimer interface [polypeptide binding]; other site 205913001497 putative catalytic residues [active] 205913001498 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 205913001499 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 205913001500 amphipathic channel; other site 205913001501 Asn-Pro-Ala signature motifs; other site 205913001502 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 205913001503 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913001504 RNA binding surface [nucleotide binding]; other site 205913001505 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 205913001506 active site 205913001507 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 205913001508 AAA domain; Region: AAA_17; pfam13207 205913001509 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 205913001510 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 205913001511 G1 box; other site 205913001512 GTP/Mg2+ binding site [chemical binding]; other site 205913001513 Switch I region; other site 205913001514 G2 box; other site 205913001515 Switch II region; other site 205913001516 G3 box; other site 205913001517 G4 box; other site 205913001518 G5 box; other site 205913001519 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 205913001520 G1 box; other site 205913001521 GTP/Mg2+ binding site [chemical binding]; other site 205913001522 Switch I region; other site 205913001523 G2 box; other site 205913001524 G3 box; other site 205913001525 Switch II region; other site 205913001526 G4 box; other site 205913001527 G5 box; other site 205913001528 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913001529 active site 205913001530 Predicted transcriptional regulator [Transcription]; Region: COG2378 205913001531 WYL domain; Region: WYL; pfam13280 205913001532 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205913001533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913001534 ATP binding site [chemical binding]; other site 205913001535 putative Mg++ binding site [ion binding]; other site 205913001536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913001537 nucleotide binding region [chemical binding]; other site 205913001538 ATP-binding site [chemical binding]; other site 205913001539 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 205913001540 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 205913001541 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 205913001542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913001543 motif II; other site 205913001544 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 205913001545 DNA binding residues [nucleotide binding] 205913001546 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205913001547 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 205913001548 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913001549 phosphopeptide binding site; other site 205913001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 205913001551 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 205913001552 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 205913001553 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 205913001554 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 205913001555 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 205913001556 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 205913001557 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 205913001558 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 205913001559 homodimer interface [polypeptide binding]; other site 205913001560 putative metal binding site [ion binding]; other site 205913001561 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 205913001562 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 205913001563 substrate binding site [chemical binding]; other site 205913001564 hexamer interface [polypeptide binding]; other site 205913001565 metal binding site [ion binding]; metal-binding site 205913001566 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 205913001567 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 205913001568 substrate binding site [chemical binding]; other site 205913001569 active site 205913001570 catalytic residues [active] 205913001571 heterodimer interface [polypeptide binding]; other site 205913001572 tryptophan synthase subunit beta; Validated; Region: PRK04346 205913001573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913001574 endonuclease IV; Provisional; Region: PRK01060 205913001575 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 205913001576 AP (apurinic/apyrimidinic) site pocket; other site 205913001577 DNA interaction; other site 205913001578 Metal-binding active site; metal-binding site 205913001579 S-methylmethionine transporter; Provisional; Region: PRK11387 205913001580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913001582 putative substrate translocation pore; other site 205913001583 VanZ like family; Region: VanZ; pfam04892 205913001584 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 205913001585 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 205913001586 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 205913001587 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205913001588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913001589 Coenzyme A binding pocket [chemical binding]; other site 205913001590 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 205913001591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205913001592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205913001593 Abi-like protein; Region: Abi_2; pfam07751 205913001594 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 205913001595 Predicted amidohydrolase [General function prediction only]; Region: COG0388 205913001596 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 205913001597 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 205913001598 nudix motif; other site 205913001599 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 205913001600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913001601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913001602 S-methylmethionine transporter; Provisional; Region: PRK11387 205913001603 Spore germination protein; Region: Spore_permease; cl17796 205913001604 Helix-turn-helix domain; Region: HTH_38; pfam13936 205913001605 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913001606 Integrase core domain; Region: rve; pfam00665 205913001607 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 205913001608 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205913001609 Catalytic site [active] 205913001610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913001611 ABC transporter signature motif; other site 205913001612 Walker B; other site 205913001613 D-loop; other site 205913001614 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205913001615 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 205913001616 Fic/DOC family; Region: Fic; pfam02661 205913001617 Uncharacterized conserved protein [Function unknown]; Region: COG3189 205913001618 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 205913001619 aspartate aminotransferase; Provisional; Region: PRK06836 205913001620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913001621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913001622 homodimer interface [polypeptide binding]; other site 205913001623 catalytic residue [active] 205913001624 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 205913001625 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 205913001626 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 205913001627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913001628 motif II; other site 205913001629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205913001630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205913001631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205913001632 dimerization interface [polypeptide binding]; other site 205913001633 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 205913001634 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913001635 active site 205913001636 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 205913001637 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 205913001638 heterodimer interface [polypeptide binding]; other site 205913001639 active site 205913001640 FMN binding site [chemical binding]; other site 205913001641 homodimer interface [polypeptide binding]; other site 205913001642 substrate binding site [chemical binding]; other site 205913001643 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 205913001644 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 205913001645 FAD binding pocket [chemical binding]; other site 205913001646 FAD binding motif [chemical binding]; other site 205913001647 phosphate binding motif [ion binding]; other site 205913001648 beta-alpha-beta structure motif; other site 205913001649 NAD binding pocket [chemical binding]; other site 205913001650 Iron coordination center [ion binding]; other site 205913001651 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 205913001652 active site 205913001653 dimer interface [polypeptide binding]; other site 205913001654 dihydroorotase; Validated; Region: pyrC; PRK09357 205913001655 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 205913001656 active site 205913001657 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 205913001658 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 205913001659 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 205913001660 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 205913001661 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205913001662 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205913001663 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 205913001664 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205913001665 metal binding triad; other site 205913001666 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205913001667 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205913001668 metal binding triad; other site 205913001669 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205913001670 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 205913001671 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 205913001672 active site 205913001673 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 205913001674 FAD binding site [chemical binding]; other site 205913001675 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 205913001676 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 205913001677 THF binding site; other site 205913001678 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 205913001679 substrate binding site [chemical binding]; other site 205913001680 THF binding site; other site 205913001681 zinc-binding site [ion binding]; other site 205913001682 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001683 catalytic core [active] 205913001684 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 205913001685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913001686 S-adenosylmethionine binding site [chemical binding]; other site 205913001687 Predicted esterase [General function prediction only]; Region: COG0400 205913001688 putative hydrolase; Provisional; Region: PRK11460 205913001689 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913001690 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 205913001691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913001692 active site 205913001693 catalytic tetrad [active] 205913001694 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913001695 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205913001696 SWIM zinc finger; Region: SWIM; pfam04434 205913001697 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 205913001698 Predicted permeases [General function prediction only]; Region: RarD; COG2962 205913001699 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 205913001700 GIY-YIG motif/motif A; other site 205913001701 putative active site [active] 205913001702 putative metal binding site [ion binding]; other site 205913001703 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 205913001704 Uncharacterized conserved protein [Function unknown]; Region: COG3410 205913001705 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 205913001706 homodimer interface [polypeptide binding]; other site 205913001707 chemical substrate binding site [chemical binding]; other site 205913001708 oligomer interface [polypeptide binding]; other site 205913001709 metal binding site [ion binding]; metal-binding site 205913001710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913001711 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 205913001712 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205913001713 catalytic triad [active] 205913001714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913001715 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 205913001716 active site 205913001717 motif I; other site 205913001718 motif II; other site 205913001719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913001720 Helix-turn-helix domain; Region: HTH_38; pfam13936 205913001721 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913001722 Integrase core domain; Region: rve; pfam00665 205913001723 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 205913001724 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 205913001725 Walker A/P-loop; other site 205913001726 ATP binding site [chemical binding]; other site 205913001727 Q-loop/lid; other site 205913001728 ABC transporter signature motif; other site 205913001729 Walker B; other site 205913001730 D-loop; other site 205913001731 H-loop/switch region; other site 205913001732 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 205913001733 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 205913001734 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 205913001735 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 205913001736 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913001737 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 205913001738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205913001739 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 205913001740 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 205913001741 active site 205913001742 dimer interface [polypeptide binding]; other site 205913001743 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 205913001744 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 205913001745 active site 205913001746 FMN binding site [chemical binding]; other site 205913001747 substrate binding site [chemical binding]; other site 205913001748 3Fe-4S cluster binding site [ion binding]; other site 205913001749 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 205913001750 domain interface; other site 205913001751 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913001752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913001753 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 205913001754 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 205913001755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913001756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913001757 DNA binding site [nucleotide binding] 205913001758 domain linker motif; other site 205913001759 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 205913001760 ligand binding site [chemical binding]; other site 205913001761 dimerization interface (open form) [polypeptide binding]; other site 205913001762 dimerization interface (closed form) [polypeptide binding]; other site 205913001763 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 205913001764 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205913001765 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 205913001766 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 205913001767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913001768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913001769 DNA binding site [nucleotide binding] 205913001770 domain linker motif; other site 205913001771 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913001772 dimerization interface [polypeptide binding]; other site 205913001773 ligand binding site [chemical binding]; other site 205913001774 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 205913001775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205913001776 FeS/SAM binding site; other site 205913001777 HemN C-terminal domain; Region: HemN_C; pfam06969 205913001778 GTP-binding protein LepA; Provisional; Region: PRK05433 205913001779 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 205913001780 G1 box; other site 205913001781 putative GEF interaction site [polypeptide binding]; other site 205913001782 GTP/Mg2+ binding site [chemical binding]; other site 205913001783 Switch I region; other site 205913001784 G2 box; other site 205913001785 G3 box; other site 205913001786 Switch II region; other site 205913001787 G4 box; other site 205913001788 G5 box; other site 205913001789 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 205913001790 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 205913001791 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 205913001792 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 205913001793 UPF0126 domain; Region: UPF0126; pfam03458 205913001794 Predicted membrane protein [Function unknown]; Region: COG2860 205913001795 UPF0126 domain; Region: UPF0126; pfam03458 205913001796 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 205913001797 homodimer interface [polypeptide binding]; other site 205913001798 MazG family protein; Region: mazG; TIGR00444 205913001799 metal binding site [ion binding]; metal-binding site 205913001800 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 205913001801 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 205913001802 homodimer interface [polypeptide binding]; other site 205913001803 substrate-cofactor binding pocket; other site 205913001804 catalytic residue [active] 205913001805 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 205913001806 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 205913001807 5S rRNA interface [nucleotide binding]; other site 205913001808 CTC domain interface [polypeptide binding]; other site 205913001809 L16 interface [polypeptide binding]; other site 205913001810 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 205913001811 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 205913001812 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 205913001813 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 205913001814 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 205913001815 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 205913001816 ligand binding site [chemical binding]; other site 205913001817 homodimer interface [polypeptide binding]; other site 205913001818 NAD(P) binding site [chemical binding]; other site 205913001819 trimer interface B [polypeptide binding]; other site 205913001820 trimer interface A [polypeptide binding]; other site 205913001821 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913001822 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 205913001823 acyl-activating enzyme (AAE) consensus motif; other site 205913001824 putative AMP binding site [chemical binding]; other site 205913001825 putative active site [active] 205913001826 putative CoA binding site [chemical binding]; other site 205913001827 GTPase Era; Reviewed; Region: era; PRK00089 205913001828 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 205913001829 G1 box; other site 205913001830 GTP/Mg2+ binding site [chemical binding]; other site 205913001831 Switch I region; other site 205913001832 G2 box; other site 205913001833 Switch II region; other site 205913001834 G3 box; other site 205913001835 G4 box; other site 205913001836 G5 box; other site 205913001837 KH domain; Region: KH_2; pfam07650 205913001838 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 205913001839 Domain of unknown function DUF21; Region: DUF21; pfam01595 205913001840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205913001841 Transporter associated domain; Region: CorC_HlyC; smart01091 205913001842 metal-binding heat shock protein; Provisional; Region: PRK00016 205913001843 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 205913001844 PhoH-like protein; Region: PhoH; pfam02562 205913001845 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 205913001846 nucleotide binding site/active site [active] 205913001847 HIT family signature motif; other site 205913001848 catalytic residue [active] 205913001849 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 205913001850 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 205913001851 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 205913001852 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 205913001853 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 205913001854 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 205913001855 ligand binding site; other site 205913001856 oligomer interface; other site 205913001857 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 205913001858 dimer interface [polypeptide binding]; other site 205913001859 N-terminal domain interface [polypeptide binding]; other site 205913001860 sulfate 1 binding site; other site 205913001861 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 205913001862 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 205913001863 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 205913001864 trimerization site [polypeptide binding]; other site 205913001865 active site 205913001866 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 205913001867 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 205913001868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913001869 catalytic residue [active] 205913001870 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 205913001871 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 205913001872 Walker A/P-loop; other site 205913001873 ATP binding site [chemical binding]; other site 205913001874 Q-loop/lid; other site 205913001875 ABC transporter signature motif; other site 205913001876 Walker B; other site 205913001877 D-loop; other site 205913001878 H-loop/switch region; other site 205913001879 FeS assembly protein SufD; Region: sufD; TIGR01981 205913001880 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 205913001881 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 205913001882 FeS assembly protein SufB; Region: sufB; TIGR01980 205913001883 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205913001884 CTP synthetase; Validated; Region: pyrG; PRK05380 205913001885 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 205913001886 Catalytic site [active] 205913001887 active site 205913001888 UTP binding site [chemical binding]; other site 205913001889 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 205913001890 active site 205913001891 putative oxyanion hole; other site 205913001892 catalytic triad [active] 205913001893 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 205913001894 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 205913001895 metal binding site [ion binding]; metal-binding site 205913001896 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 205913001897 Dehydroquinase class II; Region: DHquinase_II; pfam01220 205913001898 trimer interface [polypeptide binding]; other site 205913001899 active site 205913001900 dimer interface [polypeptide binding]; other site 205913001901 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 205913001902 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 205913001903 ADP binding site [chemical binding]; other site 205913001904 magnesium binding site [ion binding]; other site 205913001905 putative shikimate binding site; other site 205913001906 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 205913001907 active site 205913001908 dimer interface [polypeptide binding]; other site 205913001909 metal binding site [ion binding]; metal-binding site 205913001910 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 205913001911 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 205913001912 Tetramer interface [polypeptide binding]; other site 205913001913 active site 205913001914 FMN-binding site [chemical binding]; other site 205913001915 YceG-like family; Region: YceG; pfam02618 205913001916 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 205913001917 dimerization interface [polypeptide binding]; other site 205913001918 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 205913001919 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 205913001920 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 205913001921 motif 1; other site 205913001922 active site 205913001923 motif 2; other site 205913001924 motif 3; other site 205913001925 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 205913001926 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 205913001927 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913001928 catalytic core [active] 205913001929 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205913001930 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 205913001931 catalytic triad [active] 205913001932 catalytic triad [active] 205913001933 oxyanion hole [active] 205913001934 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 205913001935 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 205913001936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913001937 RNA binding surface [nucleotide binding]; other site 205913001938 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 205913001939 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913001940 Walker A/P-loop; other site 205913001941 ATP binding site [chemical binding]; other site 205913001942 Q-loop/lid; other site 205913001943 ABC transporter signature motif; other site 205913001944 Walker B; other site 205913001945 D-loop; other site 205913001946 H-loop/switch region; other site 205913001947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913001948 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 205913001949 FtsX-like permease family; Region: FtsX; pfam02687 205913001950 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 205913001951 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 205913001952 Part of AAA domain; Region: AAA_19; pfam13245 205913001953 Family description; Region: UvrD_C_2; pfam13538 205913001954 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913001955 active site 205913001956 xanthine permease; Region: pbuX; TIGR03173 205913001957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913001958 salt bridge; other site 205913001959 non-specific DNA binding site [nucleotide binding]; other site 205913001960 sequence-specific DNA binding site [nucleotide binding]; other site 205913001961 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 205913001962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205913001963 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 205913001964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205913001965 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 205913001966 Isochorismatase family; Region: Isochorismatase; pfam00857 205913001967 catalytic triad [active] 205913001968 metal binding site [ion binding]; metal-binding site 205913001969 conserved cis-peptide bond; other site 205913001970 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913001971 Divergent AAA domain; Region: AAA_4; pfam04326 205913001972 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205913001973 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 205913001974 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 205913001975 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 205913001976 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 205913001977 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 205913001978 Walker A/P-loop; other site 205913001979 ATP binding site [chemical binding]; other site 205913001980 Q-loop/lid; other site 205913001981 ABC transporter signature motif; other site 205913001982 Walker B; other site 205913001983 D-loop; other site 205913001984 H-loop/switch region; other site 205913001985 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 205913001986 Histidine kinase; Region: HisKA_3; pfam07730 205913001987 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 205913001988 ATP binding site [chemical binding]; other site 205913001989 Mg2+ binding site [ion binding]; other site 205913001990 G-X-G motif; other site 205913001991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913001992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913001993 active site 205913001994 phosphorylation site [posttranslational modification] 205913001995 intermolecular recognition site; other site 205913001996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205913001997 DNA binding residues [nucleotide binding] 205913001998 dimerization interface [polypeptide binding]; other site 205913001999 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 205913002000 Phosphate transporter family; Region: PHO4; pfam01384 205913002001 Protein of unknown function (DUF466); Region: DUF466; cl01082 205913002002 carbon starvation protein A; Provisional; Region: PRK15015 205913002003 Carbon starvation protein CstA; Region: CstA; pfam02554 205913002004 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 205913002005 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 205913002006 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 205913002007 active site 205913002008 catalytic site [active] 205913002009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913002010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913002011 WHG domain; Region: WHG; pfam13305 205913002012 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 205913002013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 205913002014 ATP binding site [chemical binding]; other site 205913002015 putative Mg++ binding site [ion binding]; other site 205913002016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002017 nucleotide binding region [chemical binding]; other site 205913002018 ATP-binding site [chemical binding]; other site 205913002019 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 205913002020 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913002021 catalytic core [active] 205913002022 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 205913002023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205913002024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913002025 non-specific DNA binding site [nucleotide binding]; other site 205913002026 salt bridge; other site 205913002027 sequence-specific DNA binding site [nucleotide binding]; other site 205913002028 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 205913002029 Short C-terminal domain; Region: SHOCT; pfam09851 205913002030 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913002031 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913002032 active site 205913002033 ATP binding site [chemical binding]; other site 205913002034 substrate binding site [chemical binding]; other site 205913002035 activation loop (A-loop); other site 205913002036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002037 H+ Antiporter protein; Region: 2A0121; TIGR00900 205913002038 putative substrate translocation pore; other site 205913002039 putative transporter; Provisional; Region: PRK10504 205913002040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002041 putative substrate translocation pore; other site 205913002042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002043 FOG: CBS domain [General function prediction only]; Region: COG0517 205913002044 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 205913002045 hypothetical protein; Provisional; Region: PRK11770 205913002046 Domain of unknown function (DUF307); Region: DUF307; pfam03733 205913002047 Domain of unknown function (DUF307); Region: DUF307; pfam03733 205913002048 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913002049 active site 205913002050 metal binding site [ion binding]; metal-binding site 205913002051 hypothetical protein; Provisional; Region: PRK06762 205913002052 AAA domain; Region: AAA_33; pfam13671 205913002053 RNA ligase; Region: RNA_lig_T4_1; pfam09511 205913002054 GTP-binding protein YchF; Reviewed; Region: PRK09601 205913002055 YchF GTPase; Region: YchF; cd01900 205913002056 G1 box; other site 205913002057 GTP/Mg2+ binding site [chemical binding]; other site 205913002058 Switch I region; other site 205913002059 G2 box; other site 205913002060 Switch II region; other site 205913002061 G3 box; other site 205913002062 G4 box; other site 205913002063 G5 box; other site 205913002064 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 205913002065 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 205913002066 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 205913002067 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 205913002068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205913002069 Histidine kinase; Region: HisKA_3; pfam07730 205913002070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913002071 ATP binding site [chemical binding]; other site 205913002072 Mg2+ binding site [ion binding]; other site 205913002073 G-X-G motif; other site 205913002074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913002075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913002076 active site 205913002077 phosphorylation site [posttranslational modification] 205913002078 intermolecular recognition site; other site 205913002079 dimerization interface [polypeptide binding]; other site 205913002080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205913002081 DNA binding residues [nucleotide binding] 205913002082 dimerization interface [polypeptide binding]; other site 205913002083 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913002084 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 205913002085 FtsX-like permease family; Region: FtsX; pfam02687 205913002086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913002087 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913002088 Walker A/P-loop; other site 205913002089 ATP binding site [chemical binding]; other site 205913002090 Q-loop/lid; other site 205913002091 ABC transporter signature motif; other site 205913002092 Walker B; other site 205913002093 D-loop; other site 205913002094 H-loop/switch region; other site 205913002095 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 205913002096 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205913002097 homodimer interface [polypeptide binding]; other site 205913002098 substrate-cofactor binding pocket; other site 205913002099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002100 catalytic residue [active] 205913002101 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 205913002102 dimer interface [polypeptide binding]; other site 205913002103 pyridoxal binding site [chemical binding]; other site 205913002104 ATP binding site [chemical binding]; other site 205913002105 hypothetical protein; Provisional; Region: PRK14681 205913002106 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 205913002107 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 205913002108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913002109 Walker A motif; other site 205913002110 ATP binding site [chemical binding]; other site 205913002111 Walker B motif; other site 205913002112 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 205913002113 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 205913002114 DNA protecting protein DprA; Region: dprA; TIGR00732 205913002115 L-aspartate oxidase; Provisional; Region: PRK06175 205913002116 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 205913002117 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 205913002118 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 205913002119 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 205913002120 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 205913002121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 205913002122 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 205913002123 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 205913002124 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 205913002125 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 205913002126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913002127 Walker A motif; other site 205913002128 ATP binding site [chemical binding]; other site 205913002129 Walker B motif; other site 205913002130 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 205913002131 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 205913002132 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205913002133 oligomer interface [polypeptide binding]; other site 205913002134 active site residues [active] 205913002135 Clp protease; Region: CLP_protease; pfam00574 205913002136 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 205913002137 oligomer interface [polypeptide binding]; other site 205913002138 active site residues [active] 205913002139 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 205913002140 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 205913002141 putative ion selectivity filter; other site 205913002142 putative pore gating glutamate residue; other site 205913002143 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 205913002144 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 205913002145 dimer interface [polypeptide binding]; other site 205913002146 trigger factor; Provisional; Region: tig; PRK01490 205913002147 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205913002148 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 205913002149 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205913002150 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 205913002151 active site 205913002152 catalytic site [active] 205913002153 substrate binding site [chemical binding]; other site 205913002154 HRDC domain; Region: HRDC; pfam00570 205913002155 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 205913002156 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 205913002157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 205913002158 FeS/SAM binding site; other site 205913002159 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 205913002160 Pyruvate formate lyase 1; Region: PFL1; cd01678 205913002161 coenzyme A binding site [chemical binding]; other site 205913002162 active site 205913002163 catalytic residues [active] 205913002164 glycine loop; other site 205913002165 NAD synthetase; Provisional; Region: PRK13981 205913002166 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 205913002167 multimer interface [polypeptide binding]; other site 205913002168 active site 205913002169 catalytic triad [active] 205913002170 protein interface 1 [polypeptide binding]; other site 205913002171 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 205913002172 homodimer interface [polypeptide binding]; other site 205913002173 NAD binding pocket [chemical binding]; other site 205913002174 ATP binding pocket [chemical binding]; other site 205913002175 Mg binding site [ion binding]; other site 205913002176 active-site loop [active] 205913002177 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 205913002178 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 205913002179 metal binding site [ion binding]; metal-binding site 205913002180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205913002181 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 205913002182 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 205913002183 Walker A/P-loop; other site 205913002184 ATP binding site [chemical binding]; other site 205913002185 Q-loop/lid; other site 205913002186 ABC transporter signature motif; other site 205913002187 Walker B; other site 205913002188 D-loop; other site 205913002189 H-loop/switch region; other site 205913002190 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 205913002191 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 205913002192 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 205913002193 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 205913002194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913002195 active site 205913002196 motif I; other site 205913002197 motif II; other site 205913002198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 205913002199 putative phosphoketolase; Provisional; Region: PRK05261 205913002200 XFP N-terminal domain; Region: XFP_N; pfam09364 205913002201 XFP C-terminal domain; Region: XFP_C; pfam09363 205913002202 GMP synthase; Reviewed; Region: guaA; PRK00074 205913002203 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 205913002204 AMP/PPi binding site [chemical binding]; other site 205913002205 candidate oxyanion hole; other site 205913002206 catalytic triad [active] 205913002207 potential glutamine specificity residues [chemical binding]; other site 205913002208 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 205913002209 ATP Binding subdomain [chemical binding]; other site 205913002210 Ligand Binding sites [chemical binding]; other site 205913002211 Dimerization subdomain; other site 205913002212 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 205913002213 Sodium Bile acid symporter family; Region: SBF; cl17470 205913002214 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 205913002215 Low molecular weight phosphatase family; Region: LMWPc; cd00115 205913002216 active site 205913002217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 205913002218 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 205913002219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913002220 Integrase core domain; Region: rve; pfam00665 205913002221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913002222 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913002223 Walker A motif; other site 205913002224 ATP binding site [chemical binding]; other site 205913002225 Walker B motif; other site 205913002226 arginine finger; other site 205913002227 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 205913002228 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 205913002229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913002230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913002231 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 205913002232 Protein of unknown function, DUF600; Region: DUF600; cl04640 205913002233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 205913002234 hypothetical protein; Provisional; Region: PRK13663 205913002235 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 205913002236 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 205913002237 catalytic triad [active] 205913002238 catalytic triad [active] 205913002239 oxyanion hole [active] 205913002240 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 205913002241 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 205913002242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913002243 active site 205913002244 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 205913002245 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 205913002246 Substrate binding site; other site 205913002247 Mg++ binding site; other site 205913002248 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 205913002249 active site 205913002250 substrate binding site [chemical binding]; other site 205913002251 CoA binding site [chemical binding]; other site 205913002252 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 205913002253 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913002254 catalytic core [active] 205913002255 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 205913002256 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 205913002257 propionate/acetate kinase; Provisional; Region: PRK12379 205913002258 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 205913002259 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 205913002260 hinge; other site 205913002261 active site 205913002262 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 205913002263 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 205913002264 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 205913002265 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 205913002266 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 205913002267 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 205913002268 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 205913002269 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 205913002270 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 205913002271 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 205913002272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205913002273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913002274 non-specific DNA binding site [nucleotide binding]; other site 205913002275 salt bridge; other site 205913002276 sequence-specific DNA binding site [nucleotide binding]; other site 205913002277 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 205913002278 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 205913002279 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 205913002280 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 205913002281 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 205913002282 active site 205913002283 catalytic site [active] 205913002284 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 205913002285 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 205913002286 dimer interface [polypeptide binding]; other site 205913002287 ADP-ribose binding site [chemical binding]; other site 205913002288 active site 205913002289 nudix motif; other site 205913002290 metal binding site [ion binding]; metal-binding site 205913002291 Uncharacterized conserved protein [Function unknown]; Region: COG0327 205913002292 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 205913002293 DNA polymerase I; Provisional; Region: PRK05755 205913002294 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 205913002295 active site 205913002296 metal binding site 1 [ion binding]; metal-binding site 205913002297 putative 5' ssDNA interaction site; other site 205913002298 metal binding site 3; metal-binding site 205913002299 metal binding site 2 [ion binding]; metal-binding site 205913002300 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 205913002301 putative DNA binding site [nucleotide binding]; other site 205913002302 putative metal binding site [ion binding]; other site 205913002303 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205913002304 active site 205913002305 substrate binding site [chemical binding]; other site 205913002306 catalytic site [active] 205913002307 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 205913002308 active site 205913002309 DNA binding site [nucleotide binding] 205913002310 catalytic site [active] 205913002311 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 205913002312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913002313 active site 205913002314 phosphorylation site [posttranslational modification] 205913002315 intermolecular recognition site; other site 205913002316 dimerization interface [polypeptide binding]; other site 205913002317 ANTAR domain; Region: ANTAR; pfam03861 205913002318 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 205913002319 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 205913002320 dimer interface [polypeptide binding]; other site 205913002321 ADP-ribose binding site [chemical binding]; other site 205913002322 active site 205913002323 nudix motif; other site 205913002324 metal binding site [ion binding]; metal-binding site 205913002325 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 205913002326 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 205913002327 domain interfaces; other site 205913002328 active site 205913002329 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 205913002330 excinuclease ABC subunit B; Provisional; Region: PRK05298 205913002331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913002332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002333 nucleotide binding region [chemical binding]; other site 205913002334 ATP-binding site [chemical binding]; other site 205913002335 Ultra-violet resistance protein B; Region: UvrB; pfam12344 205913002336 UvrB/uvrC motif; Region: UVR; pfam02151 205913002337 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 205913002338 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 205913002339 CoA-binding site [chemical binding]; other site 205913002340 ATP-binding [chemical binding]; other site 205913002341 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 205913002342 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 205913002343 RNA binding site [nucleotide binding]; other site 205913002344 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 205913002345 RNA binding site [nucleotide binding]; other site 205913002346 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 205913002347 RNA binding site [nucleotide binding]; other site 205913002348 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 205913002349 RNA binding site [nucleotide binding]; other site 205913002350 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 205913002351 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 205913002352 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 205913002353 homodimer interface [polypeptide binding]; other site 205913002354 NADP binding site [chemical binding]; other site 205913002355 substrate binding site [chemical binding]; other site 205913002356 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 205913002357 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205913002358 metal binding site [ion binding]; metal-binding site 205913002359 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 205913002360 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 205913002361 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 205913002362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 205913002363 ABC-ATPase subunit interface; other site 205913002364 dimer interface [polypeptide binding]; other site 205913002365 putative PBP binding regions; other site 205913002366 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 205913002367 homotrimer interaction site [polypeptide binding]; other site 205913002368 zinc binding site [ion binding]; other site 205913002369 CDP-binding sites; other site 205913002370 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 205913002371 glycogen branching enzyme; Provisional; Region: PRK05402 205913002372 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 205913002373 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 205913002374 active site 205913002375 catalytic site [active] 205913002376 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 205913002377 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913002378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913002379 active site 205913002380 phosphorylation site [posttranslational modification] 205913002381 intermolecular recognition site; other site 205913002382 dimerization interface [polypeptide binding]; other site 205913002383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205913002384 DNA binding site [nucleotide binding] 205913002385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 205913002386 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 205913002387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 205913002388 dimerization interface [polypeptide binding]; other site 205913002389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205913002390 dimer interface [polypeptide binding]; other site 205913002391 phosphorylation site [posttranslational modification] 205913002392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913002393 ATP binding site [chemical binding]; other site 205913002394 Mg2+ binding site [ion binding]; other site 205913002395 G-X-G motif; other site 205913002396 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 205913002397 Catalytic site [active] 205913002398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913002399 active site 205913002400 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 205913002401 Eukaryotic phosphomannomutase; Region: PMM; cl17107 205913002402 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 205913002403 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 205913002404 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913002405 Transcription factor WhiB; Region: Whib; pfam02467 205913002406 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 205913002407 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 205913002408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913002409 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913002410 Walker A/P-loop; other site 205913002411 ATP binding site [chemical binding]; other site 205913002412 Transcription factor WhiB; Region: Whib; pfam02467 205913002413 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 205913002414 PAS fold; Region: PAS_4; pfam08448 205913002415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 205913002416 Histidine kinase; Region: HisKA_2; pfam07568 205913002417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913002418 ATP binding site [chemical binding]; other site 205913002419 Mg2+ binding site [ion binding]; other site 205913002420 G-X-G motif; other site 205913002421 Haemolysin-III related; Region: HlyIII; pfam03006 205913002422 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 205913002423 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 205913002424 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 205913002425 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 205913002426 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205913002427 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 205913002428 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 205913002429 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 205913002430 exopolyphosphatase; Region: exo_poly_only; TIGR03706 205913002431 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 205913002432 Protein of unknown function (DUF501); Region: DUF501; pfam04417 205913002433 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 205913002434 Septum formation initiator; Region: DivIC; pfam04977 205913002435 enolase; Provisional; Region: eno; PRK00077 205913002436 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 205913002437 dimer interface [polypeptide binding]; other site 205913002438 metal binding site [ion binding]; metal-binding site 205913002439 substrate binding pocket [chemical binding]; other site 205913002440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913002441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913002442 active site 205913002443 catalytic tetrad [active] 205913002444 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 205913002445 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 205913002446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913002447 ATP binding site [chemical binding]; other site 205913002448 putative Mg++ binding site [ion binding]; other site 205913002449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002450 nucleotide binding region [chemical binding]; other site 205913002451 ATP-binding site [chemical binding]; other site 205913002452 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 205913002453 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 205913002454 putative active site [active] 205913002455 catalytic residue [active] 205913002456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205913002457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913002458 Coenzyme A binding pocket [chemical binding]; other site 205913002459 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 205913002460 Uncharacterized conserved protein [Function unknown]; Region: COG1615 205913002461 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 205913002462 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 205913002463 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 205913002464 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 205913002465 active site 205913002466 (T/H)XGH motif; other site 205913002467 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 205913002468 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 205913002469 putative catalytic cysteine [active] 205913002470 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913002471 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913002472 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 205913002473 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 205913002474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002475 catalytic residue [active] 205913002476 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 205913002477 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 205913002478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913002479 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 205913002480 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 205913002481 Soluble P-type ATPase [General function prediction only]; Region: COG4087 205913002482 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 205913002483 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 205913002484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 205913002485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 205913002486 Walker A/P-loop; other site 205913002487 ATP binding site [chemical binding]; other site 205913002488 Q-loop/lid; other site 205913002489 ABC transporter signature motif; other site 205913002490 Walker B; other site 205913002491 D-loop; other site 205913002492 H-loop/switch region; other site 205913002493 Predicted transcriptional regulators [Transcription]; Region: COG1725 205913002494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205913002495 DNA-binding site [nucleotide binding]; DNA binding site 205913002496 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 205913002497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913002498 motif II; other site 205913002499 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 205913002500 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 205913002501 Walker A/P-loop; other site 205913002502 ATP binding site [chemical binding]; other site 205913002503 Q-loop/lid; other site 205913002504 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 205913002505 ABC transporter signature motif; other site 205913002506 Walker B; other site 205913002507 D-loop; other site 205913002508 H-loop/switch region; other site 205913002509 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 205913002510 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 205913002511 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 205913002512 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 205913002513 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 205913002514 TrkA-N domain; Region: TrkA_N; pfam02254 205913002515 TrkA-C domain; Region: TrkA_C; pfam02080 205913002516 Protein of unknown function (DUF342); Region: DUF342; pfam03961 205913002517 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 205913002518 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913002519 RNA binding surface [nucleotide binding]; other site 205913002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913002521 S-adenosylmethionine binding site [chemical binding]; other site 205913002522 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 205913002523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913002524 active site 205913002525 motif I; other site 205913002526 motif II; other site 205913002527 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 205913002528 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 205913002529 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 205913002530 active site 205913002531 HIGH motif; other site 205913002532 dimer interface [polypeptide binding]; other site 205913002533 KMSKS motif; other site 205913002534 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 205913002535 RNA binding surface [nucleotide binding]; other site 205913002536 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 205913002537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205913002538 Zn2+ binding site [ion binding]; other site 205913002539 Mg2+ binding site [ion binding]; other site 205913002540 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 205913002541 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 205913002542 ATP binding site [chemical binding]; other site 205913002543 substrate interface [chemical binding]; other site 205913002544 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 205913002545 ThiS interaction site; other site 205913002546 putative active site [active] 205913002547 tetramer interface [polypeptide binding]; other site 205913002548 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 205913002549 thiS-thiF/thiG interaction site; other site 205913002550 argininosuccinate lyase; Provisional; Region: PRK00855 205913002551 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 205913002552 active sites [active] 205913002553 tetramer interface [polypeptide binding]; other site 205913002554 argininosuccinate synthase; Provisional; Region: PRK13820 205913002555 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 205913002556 ANP binding site [chemical binding]; other site 205913002557 Substrate Binding Site II [chemical binding]; other site 205913002558 Substrate Binding Site I [chemical binding]; other site 205913002559 arginine repressor; Provisional; Region: PRK03341 205913002560 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 205913002561 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 205913002562 ornithine carbamoyltransferase; Provisional; Region: PRK00779 205913002563 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 205913002564 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 205913002565 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 205913002566 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205913002567 inhibitor-cofactor binding pocket; inhibition site 205913002568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002569 catalytic residue [active] 205913002570 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 205913002571 feedback inhibition sensing region; other site 205913002572 homohexameric interface [polypeptide binding]; other site 205913002573 nucleotide binding site [chemical binding]; other site 205913002574 N-acetyl-L-glutamate binding site [chemical binding]; other site 205913002575 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 205913002576 heterotetramer interface [polypeptide binding]; other site 205913002577 active site pocket [active] 205913002578 cleavage site 205913002579 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 205913002580 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205913002581 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 205913002582 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 205913002583 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 205913002584 putative tRNA-binding site [nucleotide binding]; other site 205913002585 B3/4 domain; Region: B3_4; pfam03483 205913002586 tRNA synthetase B5 domain; Region: B5; pfam03484 205913002587 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 205913002588 dimer interface [polypeptide binding]; other site 205913002589 motif 1; other site 205913002590 motif 3; other site 205913002591 motif 2; other site 205913002592 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 205913002593 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 205913002594 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 205913002595 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 205913002596 dimer interface [polypeptide binding]; other site 205913002597 motif 1; other site 205913002598 active site 205913002599 motif 2; other site 205913002600 motif 3; other site 205913002601 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 205913002602 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 205913002603 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 205913002604 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 205913002605 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 205913002606 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 205913002607 Walker A/P-loop; other site 205913002608 ATP binding site [chemical binding]; other site 205913002609 Q-loop/lid; other site 205913002610 ABC transporter signature motif; other site 205913002611 Walker B; other site 205913002612 D-loop; other site 205913002613 H-loop/switch region; other site 205913002614 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205913002615 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 205913002616 Walker A/P-loop; other site 205913002617 ATP binding site [chemical binding]; other site 205913002618 Q-loop/lid; other site 205913002619 ABC transporter signature motif; other site 205913002620 Walker B; other site 205913002621 D-loop; other site 205913002622 H-loop/switch region; other site 205913002623 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 205913002624 hypothetical protein; Provisional; Region: PRK07907 205913002625 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 205913002626 active site 205913002627 metal binding site [ion binding]; metal-binding site 205913002628 dimer interface [polypeptide binding]; other site 205913002629 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 205913002630 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 205913002631 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 205913002632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205913002633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205913002634 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 205913002635 glutamine synthetase, type I; Region: GlnA; TIGR00653 205913002636 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 205913002637 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 205913002638 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 205913002639 Predicted permeases [General function prediction only]; Region: COG0679 205913002640 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 205913002641 putative CoA binding site [chemical binding]; other site 205913002642 putative trimer interface [polypeptide binding]; other site 205913002643 maltose O-acetyltransferase; Provisional; Region: PRK10092 205913002644 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 205913002645 active site 205913002646 substrate binding site [chemical binding]; other site 205913002647 trimer interface [polypeptide binding]; other site 205913002648 CoA binding site [chemical binding]; other site 205913002649 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 205913002650 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205913002651 minor groove reading motif; other site 205913002652 helix-hairpin-helix signature motif; other site 205913002653 active site 205913002654 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 205913002655 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205913002656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913002657 Walker A/P-loop; other site 205913002658 ATP binding site [chemical binding]; other site 205913002659 Q-loop/lid; other site 205913002660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913002661 ABC transporter signature motif; other site 205913002662 Walker B; other site 205913002663 D-loop; other site 205913002664 H-loop/switch region; other site 205913002665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913002666 Walker A/P-loop; other site 205913002667 ATP binding site [chemical binding]; other site 205913002668 Q-loop/lid; other site 205913002669 ABC transporter signature motif; other site 205913002670 Walker B; other site 205913002671 D-loop; other site 205913002672 H-loop/switch region; other site 205913002673 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 205913002674 AAA domain; Region: AAA_14; pfam13173 205913002675 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913002676 KDPG and KHG aldolase; Region: Aldolase; cl17259 205913002677 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205913002678 MarR family; Region: MarR_2; pfam12802 205913002679 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 205913002680 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 205913002681 DNA binding residues [nucleotide binding] 205913002682 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 205913002683 AAA domain; Region: AAA_14; pfam13173 205913002684 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205913002685 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 205913002686 catalytic Zn binding site [ion binding]; other site 205913002687 NAD(P) binding site [chemical binding]; other site 205913002688 structural Zn binding site [ion binding]; other site 205913002689 CrcB-like protein; Region: CRCB; pfam02537 205913002690 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 205913002691 Predicted membrane protein [Function unknown]; Region: COG2246 205913002692 GtrA-like protein; Region: GtrA; pfam04138 205913002693 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 205913002694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205913002695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205913002696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 205913002697 dimerization interface [polypeptide binding]; other site 205913002698 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 205913002699 elongation factor Tu; Reviewed; Region: PRK00049 205913002700 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 205913002701 G1 box; other site 205913002702 GEF interaction site [polypeptide binding]; other site 205913002703 GTP/Mg2+ binding site [chemical binding]; other site 205913002704 Switch I region; other site 205913002705 G2 box; other site 205913002706 G3 box; other site 205913002707 Switch II region; other site 205913002708 G4 box; other site 205913002709 G5 box; other site 205913002710 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 205913002711 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 205913002712 Antibiotic Binding Site [chemical binding]; other site 205913002713 elongation factor G; Reviewed; Region: PRK00007 205913002714 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 205913002715 G1 box; other site 205913002716 putative GEF interaction site [polypeptide binding]; other site 205913002717 GTP/Mg2+ binding site [chemical binding]; other site 205913002718 Switch I region; other site 205913002719 G2 box; other site 205913002720 G3 box; other site 205913002721 Switch II region; other site 205913002722 G4 box; other site 205913002723 G5 box; other site 205913002724 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 205913002725 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 205913002726 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 205913002727 30S ribosomal protein S7; Validated; Region: PRK05302 205913002728 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 205913002729 16S rRNA interaction site [nucleotide binding]; other site 205913002730 streptomycin interaction site [chemical binding]; other site 205913002731 23S rRNA interaction site [nucleotide binding]; other site 205913002732 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 205913002733 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 205913002734 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 205913002735 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913002736 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913002737 catalytic residue [active] 205913002738 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 205913002739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205913002740 putative ADP-binding pocket [chemical binding]; other site 205913002741 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 205913002742 ATP-grasp domain; Region: ATP-grasp; pfam02222 205913002743 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 205913002744 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 205913002745 ATP binding site [chemical binding]; other site 205913002746 active site 205913002747 substrate binding site [chemical binding]; other site 205913002748 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 205913002749 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 205913002750 dimerization interface [polypeptide binding]; other site 205913002751 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 205913002752 dimerization interface [polypeptide binding]; other site 205913002753 ATP binding site [chemical binding]; other site 205913002754 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 205913002755 dimerization interface [polypeptide binding]; other site 205913002756 ATP binding site [chemical binding]; other site 205913002757 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 205913002758 putative active site [active] 205913002759 catalytic triad [active] 205913002760 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913002761 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 205913002762 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 205913002763 putative active site [active] 205913002764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913002765 non-specific DNA binding site [nucleotide binding]; other site 205913002766 salt bridge; other site 205913002767 sequence-specific DNA binding site [nucleotide binding]; other site 205913002768 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 205913002769 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 205913002770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205913002771 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 205913002772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 205913002773 dimerization interface [polypeptide binding]; other site 205913002774 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913002775 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913002776 active site 205913002777 catalytic tetrad [active] 205913002778 DNA polymerase IV; Reviewed; Region: PRK03103 205913002779 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 205913002780 active site 205913002781 DNA binding site [nucleotide binding] 205913002782 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 205913002783 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 205913002784 NAD binding site [chemical binding]; other site 205913002785 guanine deaminase; Region: guan_deamin; TIGR02967 205913002786 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 205913002787 active site 205913002788 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 205913002789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205913002790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913002791 substrate binding pocket [chemical binding]; other site 205913002792 membrane-bound complex binding site; other site 205913002793 hinge residues; other site 205913002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913002795 dimer interface [polypeptide binding]; other site 205913002796 conserved gate region; other site 205913002797 putative PBP binding loops; other site 205913002798 ABC-ATPase subunit interface; other site 205913002799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913002800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205913002801 Walker A/P-loop; other site 205913002802 ATP binding site [chemical binding]; other site 205913002803 Q-loop/lid; other site 205913002804 ABC transporter signature motif; other site 205913002805 Walker B; other site 205913002806 D-loop; other site 205913002807 H-loop/switch region; other site 205913002808 amidophosphoribosyltransferase; Provisional; Region: PRK07272 205913002809 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 205913002810 active site 205913002811 tetramer interface [polypeptide binding]; other site 205913002812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913002813 active site 205913002814 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 205913002815 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 205913002816 dimerization interface [polypeptide binding]; other site 205913002817 putative ATP binding site [chemical binding]; other site 205913002818 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 205913002819 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 205913002820 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 205913002821 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 205913002822 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 205913002823 NAD(P) binding site [chemical binding]; other site 205913002824 catalytic residues [active] 205913002825 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 205913002826 Sulfatase; Region: Sulfatase; pfam00884 205913002827 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 205913002828 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 205913002829 metal binding site [ion binding]; metal-binding site 205913002830 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 205913002831 metal binding site 2 [ion binding]; metal-binding site 205913002832 putative DNA binding helix; other site 205913002833 metal binding site 1 [ion binding]; metal-binding site 205913002834 dimer interface [polypeptide binding]; other site 205913002835 structural Zn2+ binding site [ion binding]; other site 205913002836 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 205913002837 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 205913002838 NAD binding site [chemical binding]; other site 205913002839 ATP-grasp domain; Region: ATP-grasp; pfam02222 205913002840 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 205913002841 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 205913002842 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 205913002843 NAD(P) binding site [chemical binding]; other site 205913002844 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 205913002845 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 205913002846 TPP-binding site; other site 205913002847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 205913002848 PYR/PP interface [polypeptide binding]; other site 205913002849 dimer interface [polypeptide binding]; other site 205913002850 TPP binding site [chemical binding]; other site 205913002851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 205913002852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913002853 FtsX-like permease family; Region: FtsX; pfam02687 205913002854 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913002855 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913002856 Walker A/P-loop; other site 205913002857 ATP binding site [chemical binding]; other site 205913002858 Q-loop/lid; other site 205913002859 ABC transporter signature motif; other site 205913002860 Walker B; other site 205913002861 D-loop; other site 205913002862 H-loop/switch region; other site 205913002863 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205913002864 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205913002865 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 205913002866 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 205913002867 putative active site [active] 205913002868 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 205913002869 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 205913002870 transmembrane helices; other site 205913002871 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 205913002872 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 205913002873 catalytic nucleophile [active] 205913002874 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 205913002875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205913002876 DNA-binding site [nucleotide binding]; DNA binding site 205913002877 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 205913002878 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 205913002879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913002880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002881 homodimer interface [polypeptide binding]; other site 205913002882 catalytic residue [active] 205913002883 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 205913002884 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 205913002885 predicted active site [active] 205913002886 catalytic triad [active] 205913002887 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 205913002888 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 205913002889 active site 205913002890 multimer interface [polypeptide binding]; other site 205913002891 DNA primase, catalytic core; Region: dnaG; TIGR01391 205913002892 CHC2 zinc finger; Region: zf-CHC2; cl17510 205913002893 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 205913002894 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 205913002895 active site 205913002896 metal binding site [ion binding]; metal-binding site 205913002897 interdomain interaction site; other site 205913002898 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 205913002899 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 205913002900 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205913002901 Zn2+ binding site [ion binding]; other site 205913002902 Mg2+ binding site [ion binding]; other site 205913002903 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 205913002904 alanine racemase; Reviewed; Region: alr; PRK00053 205913002905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 205913002906 active site 205913002907 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205913002908 dimer interface [polypeptide binding]; other site 205913002909 substrate binding site [chemical binding]; other site 205913002910 catalytic residues [active] 205913002911 amino acid transporter; Region: 2A0306; TIGR00909 205913002912 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 205913002913 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 205913002914 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 205913002915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 205913002916 S-ribosylhomocysteinase; Provisional; Region: PRK02260 205913002917 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 205913002918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913002919 ATP binding site [chemical binding]; other site 205913002920 putative Mg++ binding site [ion binding]; other site 205913002921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913002922 nucleotide binding region [chemical binding]; other site 205913002923 ATP-binding site [chemical binding]; other site 205913002924 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 205913002925 HRDC domain; Region: HRDC; pfam00570 205913002926 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 205913002927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 205913002928 cystathionine gamma-synthase; Provisional; Region: PRK07811 205913002929 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 205913002930 homodimer interface [polypeptide binding]; other site 205913002931 substrate-cofactor binding pocket; other site 205913002932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002933 catalytic residue [active] 205913002934 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 205913002935 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 205913002936 dimer interface [polypeptide binding]; other site 205913002937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913002938 catalytic residue [active] 205913002939 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 205913002940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913002941 Walker A/P-loop; other site 205913002942 ATP binding site [chemical binding]; other site 205913002943 Q-loop/lid; other site 205913002944 ABC transporter signature motif; other site 205913002945 Walker B; other site 205913002946 D-loop; other site 205913002947 H-loop/switch region; other site 205913002948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 205913002949 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 205913002950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 205913002951 Walker A/P-loop; other site 205913002952 ATP binding site [chemical binding]; other site 205913002953 Q-loop/lid; other site 205913002954 ABC transporter signature motif; other site 205913002955 Walker B; other site 205913002956 D-loop; other site 205913002957 H-loop/switch region; other site 205913002958 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 205913002959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913002960 ABC-ATPase subunit interface; other site 205913002961 putative PBP binding loops; other site 205913002962 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 205913002963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913002964 putative PBP binding loops; other site 205913002965 dimer interface [polypeptide binding]; other site 205913002966 ABC-ATPase subunit interface; other site 205913002967 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 205913002968 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 205913002969 pantothenate kinase; Reviewed; Region: PRK13318 205913002970 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913002971 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913002972 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913002973 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913002974 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913002975 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913002976 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913002977 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 205913002978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913002979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913002980 DNA binding site [nucleotide binding] 205913002981 domain linker motif; other site 205913002982 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913002983 ligand binding site [chemical binding]; other site 205913002984 dimerization interface [polypeptide binding]; other site 205913002985 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 205913002986 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 205913002987 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 205913002988 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913002990 dimer interface [polypeptide binding]; other site 205913002991 conserved gate region; other site 205913002992 putative PBP binding loops; other site 205913002993 ABC-ATPase subunit interface; other site 205913002994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913002995 dimer interface [polypeptide binding]; other site 205913002996 conserved gate region; other site 205913002997 putative PBP binding loops; other site 205913002998 ABC-ATPase subunit interface; other site 205913002999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003001 DNA binding site [nucleotide binding] 205913003002 domain linker motif; other site 205913003003 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 205913003004 ligand binding site [chemical binding]; other site 205913003005 dimerization interface (open form) [polypeptide binding]; other site 205913003006 dimerization interface (closed form) [polypeptide binding]; other site 205913003007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 205913003008 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 205913003009 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 205913003010 active site 205913003011 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 205913003012 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 205913003013 glutaminase active site [active] 205913003014 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 205913003015 dimer interface [polypeptide binding]; other site 205913003016 active site 205913003017 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 205913003018 dimer interface [polypeptide binding]; other site 205913003019 active site 205913003020 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 205913003021 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 205913003022 Walker A/P-loop; other site 205913003023 ATP binding site [chemical binding]; other site 205913003024 Q-loop/lid; other site 205913003025 ABC transporter signature motif; other site 205913003026 Walker B; other site 205913003027 D-loop; other site 205913003028 H-loop/switch region; other site 205913003029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003030 dimer interface [polypeptide binding]; other site 205913003031 conserved gate region; other site 205913003032 putative PBP binding loops; other site 205913003033 ABC-ATPase subunit interface; other site 205913003034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205913003035 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913003036 substrate binding pocket [chemical binding]; other site 205913003037 membrane-bound complex binding site; other site 205913003038 hinge residues; other site 205913003039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 205913003040 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 205913003041 substrate binding pocket [chemical binding]; other site 205913003042 membrane-bound complex binding site; other site 205913003043 hinge residues; other site 205913003044 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 205913003045 SmpB-tmRNA interface; other site 205913003046 Surface antigen [General function prediction only]; Region: COG3942 205913003047 CHAP domain; Region: CHAP; pfam05257 205913003048 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 205913003049 FtsX-like permease family; Region: FtsX; pfam02687 205913003050 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 205913003051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913003052 Walker A/P-loop; other site 205913003053 ATP binding site [chemical binding]; other site 205913003054 Q-loop/lid; other site 205913003055 ABC transporter signature motif; other site 205913003056 Walker B; other site 205913003057 D-loop; other site 205913003058 H-loop/switch region; other site 205913003059 peptide chain release factor 2; Validated; Region: prfB; PRK00578 205913003060 This domain is found in peptide chain release factors; Region: PCRF; smart00937 205913003061 RF-1 domain; Region: RF-1; pfam00472 205913003062 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 205913003063 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 205913003064 active site 205913003065 substrate binding site [chemical binding]; other site 205913003066 catalytic site [active] 205913003067 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205913003068 active site 205913003069 catalytic residues [active] 205913003070 metal binding site [ion binding]; metal-binding site 205913003071 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 205913003072 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 205913003073 active site 205913003074 substrate binding site [chemical binding]; other site 205913003075 metal binding site [ion binding]; metal-binding site 205913003076 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 205913003077 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 205913003078 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 205913003079 Zn binding site [ion binding]; other site 205913003080 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 205913003081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 205913003082 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 205913003083 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 205913003084 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 205913003085 dimer interface [polypeptide binding]; other site 205913003086 active site 205913003087 catalytic residue [active] 205913003088 dihydrodipicolinate reductase; Provisional; Region: PRK00048 205913003089 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 205913003090 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 205913003091 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913003092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003093 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 205913003094 Family description; Region: UvrD_C_2; pfam13538 205913003095 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 205913003096 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 205913003097 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 205913003098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913003099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913003100 active site 205913003101 ATP binding site [chemical binding]; other site 205913003102 substrate binding site [chemical binding]; other site 205913003103 activation loop (A-loop); other site 205913003104 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205913003105 Interdomain contacts; other site 205913003106 Cytokine receptor motif; other site 205913003107 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 205913003108 Interdomain contacts; other site 205913003109 Cytokine receptor motif; other site 205913003110 MoxR-like ATPases [General function prediction only]; Region: COG0714 205913003111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913003112 Walker A motif; other site 205913003113 ATP binding site [chemical binding]; other site 205913003114 Walker B motif; other site 205913003115 arginine finger; other site 205913003116 Protein of unknown function DUF58; Region: DUF58; pfam01882 205913003117 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 205913003118 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205913003119 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 205913003120 active site 205913003121 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913003122 phosphopeptide binding site; other site 205913003123 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 205913003124 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 205913003125 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 205913003126 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 205913003127 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 205913003128 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 205913003129 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 205913003130 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 205913003131 DNA binding site [nucleotide binding] 205913003132 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 205913003133 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 205913003134 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 205913003135 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 205913003136 RPB1 interaction site [polypeptide binding]; other site 205913003137 RPB10 interaction site [polypeptide binding]; other site 205913003138 RPB11 interaction site [polypeptide binding]; other site 205913003139 RPB3 interaction site [polypeptide binding]; other site 205913003140 RPB12 interaction site [polypeptide binding]; other site 205913003141 Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072 205913003142 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 205913003143 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205913003144 minor groove reading motif; other site 205913003145 helix-hairpin-helix signature motif; other site 205913003146 active site 205913003147 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 205913003148 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 205913003149 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 205913003150 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 205913003151 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003153 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 205913003154 galactokinase; Provisional; Region: PRK05322 205913003155 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 205913003156 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 205913003157 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 205913003158 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 205913003159 dimer interface [polypeptide binding]; other site 205913003160 active site 205913003161 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 205913003162 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 205913003163 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 205913003164 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 205913003165 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 205913003166 quinone interaction residues [chemical binding]; other site 205913003167 active site 205913003168 catalytic residues [active] 205913003169 FMN binding site [chemical binding]; other site 205913003170 substrate binding site [chemical binding]; other site 205913003171 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 205913003172 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 205913003173 active site 205913003174 FMN binding site [chemical binding]; other site 205913003175 substrate binding site [chemical binding]; other site 205913003176 homotetramer interface [polypeptide binding]; other site 205913003177 catalytic residue [active] 205913003178 Transglycosylase; Region: Transgly; pfam00912 205913003179 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 205913003180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 205913003181 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 205913003182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 205913003183 ligand binding site [chemical binding]; other site 205913003184 flexible hinge region; other site 205913003185 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205913003186 putative switch regulator; other site 205913003187 non-specific DNA interactions [nucleotide binding]; other site 205913003188 DNA binding site [nucleotide binding] 205913003189 sequence specific DNA binding site [nucleotide binding]; other site 205913003190 putative cAMP binding site [chemical binding]; other site 205913003191 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 205913003192 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 205913003193 tartrate dehydrogenase; Region: TTC; TIGR02089 205913003194 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 205913003195 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 205913003196 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205913003197 Uncharacterized conserved protein [Function unknown]; Region: COG4850 205913003198 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 205913003199 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 205913003200 lipoyl attachment site [posttranslational modification]; other site 205913003201 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 205913003202 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 205913003203 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 205913003204 putative NADH binding site [chemical binding]; other site 205913003205 putative active site [active] 205913003206 nudix motif; other site 205913003207 putative metal binding site [ion binding]; other site 205913003208 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205913003209 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 205913003210 nudix motif; other site 205913003211 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 205913003212 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 205913003213 catalytic residues [active] 205913003214 Domain of unknown function (DUF348); Region: DUF348; pfam03990 205913003215 G5 domain; Region: G5; pfam07501 205913003216 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205913003217 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205913003218 catalytic residue [active] 205913003219 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205913003220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 205913003221 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 205913003222 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 205913003223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913003224 DNA-binding interface [nucleotide binding]; DNA binding site 205913003225 Integrase core domain; Region: rve; pfam00665 205913003226 transposase/IS protein; Provisional; Region: PRK09183 205913003227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913003228 Walker A motif; other site 205913003229 ATP binding site [chemical binding]; other site 205913003230 Walker B motif; other site 205913003231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 205913003232 Transposase; Region: HTH_Tnp_1; cl17663 205913003233 putative transposase OrfB; Reviewed; Region: PHA02517 205913003234 HTH-like domain; Region: HTH_21; pfam13276 205913003235 Integrase core domain; Region: rve; pfam00665 205913003236 Integrase core domain; Region: rve_2; pfam13333 205913003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003238 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 205913003239 putative substrate translocation pore; other site 205913003240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913003242 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 205913003243 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 205913003244 AAA domain; Region: AAA_14; pfam13173 205913003245 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 205913003246 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 205913003247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913003248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913003249 active site 205913003250 catalytic tetrad [active] 205913003251 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 205913003252 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 205913003253 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913003254 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003256 DNA binding site [nucleotide binding] 205913003257 domain linker motif; other site 205913003258 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003259 ligand binding site [chemical binding]; other site 205913003260 dimerization interface [polypeptide binding]; other site 205913003261 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 205913003262 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 205913003263 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 205913003264 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 205913003265 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913003266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003267 dimer interface [polypeptide binding]; other site 205913003268 conserved gate region; other site 205913003269 putative PBP binding loops; other site 205913003270 ABC-ATPase subunit interface; other site 205913003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003272 dimer interface [polypeptide binding]; other site 205913003273 conserved gate region; other site 205913003274 putative PBP binding loops; other site 205913003275 ABC-ATPase subunit interface; other site 205913003276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913003277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913003278 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 205913003279 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 205913003280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913003281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913003282 Walker A/P-loop; other site 205913003283 ATP binding site [chemical binding]; other site 205913003284 Q-loop/lid; other site 205913003285 ABC transporter signature motif; other site 205913003286 Walker B; other site 205913003287 D-loop; other site 205913003288 H-loop/switch region; other site 205913003289 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913003290 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913003291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913003292 Walker A/P-loop; other site 205913003293 ATP binding site [chemical binding]; other site 205913003294 Q-loop/lid; other site 205913003295 ABC transporter signature motif; other site 205913003296 Walker B; other site 205913003297 D-loop; other site 205913003298 H-loop/switch region; other site 205913003299 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913003300 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 205913003301 acyl-activating enzyme (AAE) consensus motif; other site 205913003302 putative AMP binding site [chemical binding]; other site 205913003303 putative active site [active] 205913003304 putative CoA binding site [chemical binding]; other site 205913003305 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913003306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003307 Walker A/P-loop; other site 205913003308 ATP binding site [chemical binding]; other site 205913003309 Q-loop/lid; other site 205913003310 ABC transporter signature motif; other site 205913003311 Walker B; other site 205913003312 D-loop; other site 205913003313 H-loop/switch region; other site 205913003314 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913003315 FtsX-like permease family; Region: FtsX; pfam02687 205913003316 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 205913003317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913003318 FtsX-like permease family; Region: FtsX; pfam02687 205913003319 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 205913003320 Peptidase C26; Region: Peptidase_C26; pfam07722 205913003321 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 205913003322 catalytic triad [active] 205913003323 L-arabinose isomerase; Provisional; Region: PRK02929 205913003324 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 205913003325 hexamer (dimer of trimers) interface [polypeptide binding]; other site 205913003326 trimer interface [polypeptide binding]; other site 205913003327 substrate binding site [chemical binding]; other site 205913003328 Mn binding site [ion binding]; other site 205913003329 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 205913003330 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 205913003331 intersubunit interface [polypeptide binding]; other site 205913003332 active site 205913003333 Zn2+ binding site [ion binding]; other site 205913003334 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 205913003335 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 205913003336 putative N- and C-terminal domain interface [polypeptide binding]; other site 205913003337 putative active site [active] 205913003338 MgATP binding site [chemical binding]; other site 205913003339 catalytic site [active] 205913003340 metal binding site [ion binding]; metal-binding site 205913003341 putative carbohydrate binding site [chemical binding]; other site 205913003342 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003343 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003344 DNA binding site [nucleotide binding] 205913003345 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 205913003346 ligand binding site [chemical binding]; other site 205913003347 dimerization interface (open form) [polypeptide binding]; other site 205913003348 dimerization interface (closed form) [polypeptide binding]; other site 205913003349 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 205913003350 RNA/DNA hybrid binding site [nucleotide binding]; other site 205913003351 active site 205913003352 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 205913003353 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 205913003354 Catalytic site [active] 205913003355 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 205913003356 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 205913003357 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 205913003358 active site 205913003359 dimer interface [polypeptide binding]; other site 205913003360 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 205913003361 dimer interface [polypeptide binding]; other site 205913003362 active site 205913003363 Membrane transport protein; Region: Mem_trans; cl09117 205913003364 FemAB family; Region: FemAB; pfam02388 205913003365 FemAB family; Region: FemAB; pfam02388 205913003366 FemAB family; Region: FemAB; pfam02388 205913003367 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 205913003368 active site 205913003369 dimerization interface [polypeptide binding]; other site 205913003370 ribonuclease PH; Reviewed; Region: rph; PRK00173 205913003371 Ribonuclease PH; Region: RNase_PH_bact; cd11362 205913003372 hexamer interface [polypeptide binding]; other site 205913003373 active site 205913003374 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 205913003375 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 205913003376 active site 205913003377 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 205913003378 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 205913003379 DNA binding residues [nucleotide binding] 205913003380 putative dimer interface [polypeptide binding]; other site 205913003381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913003382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913003383 active site 205913003384 catalytic tetrad [active] 205913003385 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 205913003386 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 205913003387 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 205913003388 active site 205913003389 (T/H)XGH motif; other site 205913003390 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 205913003391 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 205913003392 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 205913003393 ribonuclease III; Reviewed; Region: rnc; PRK00102 205913003394 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 205913003395 dimerization interface [polypeptide binding]; other site 205913003396 active site 205913003397 metal binding site [ion binding]; metal-binding site 205913003398 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 205913003399 dsRNA binding site [nucleotide binding]; other site 205913003400 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 205913003401 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 205913003402 PYR/PP interface [polypeptide binding]; other site 205913003403 dimer interface [polypeptide binding]; other site 205913003404 TPP binding site [chemical binding]; other site 205913003405 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 205913003406 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 205913003407 TPP-binding site [chemical binding]; other site 205913003408 dimer interface [polypeptide binding]; other site 205913003409 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 205913003410 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 205913003411 putative valine binding site [chemical binding]; other site 205913003412 dimer interface [polypeptide binding]; other site 205913003413 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 205913003414 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 205913003415 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 205913003416 oligomeric interface; other site 205913003417 putative active site [active] 205913003418 homodimer interface [polypeptide binding]; other site 205913003419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205913003421 ABC transporter; Region: ABC_tran_2; pfam12848 205913003422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003423 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205913003424 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 205913003425 catalytic triad [active] 205913003426 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 205913003427 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205913003428 active site 205913003429 HIGH motif; other site 205913003430 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 205913003431 KMSKS motif; other site 205913003432 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205913003433 tRNA binding surface [nucleotide binding]; other site 205913003434 anticodon binding site; other site 205913003435 Cation efflux family; Region: Cation_efflux; pfam01545 205913003436 signal recognition particle protein; Provisional; Region: PRK10867 205913003437 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 205913003438 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 205913003439 P loop; other site 205913003440 GTP binding site [chemical binding]; other site 205913003441 Signal peptide binding domain; Region: SRP_SPB; pfam02978 205913003442 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205913003443 putative catalytic site [active] 205913003444 putative metal binding site [ion binding]; other site 205913003445 putative phosphate binding site [ion binding]; other site 205913003446 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 205913003447 hypothetical protein; Provisional; Region: PRK02821 205913003448 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 205913003449 G-X-X-G motif; other site 205913003450 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 205913003451 RimM N-terminal domain; Region: RimM; pfam01782 205913003452 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205913003453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913003454 non-specific DNA binding site [nucleotide binding]; other site 205913003455 salt bridge; other site 205913003456 sequence-specific DNA binding site [nucleotide binding]; other site 205913003457 HipA N-terminal domain; Region: Couple_hipA; cl11853 205913003458 HipA-like N-terminal domain; Region: HipA_N; pfam07805 205913003459 HipA-like C-terminal domain; Region: HipA_C; pfam07804 205913003460 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003462 dimer interface [polypeptide binding]; other site 205913003463 conserved gate region; other site 205913003464 putative PBP binding loops; other site 205913003465 ABC-ATPase subunit interface; other site 205913003466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003467 dimer interface [polypeptide binding]; other site 205913003468 conserved gate region; other site 205913003469 putative PBP binding loops; other site 205913003470 ABC-ATPase subunit interface; other site 205913003471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913003472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913003473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913003474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913003475 DNA binding site [nucleotide binding] 205913003476 domain linker motif; other site 205913003477 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913003478 dimerization interface [polypeptide binding]; other site 205913003479 ligand binding site [chemical binding]; other site 205913003480 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 205913003481 active site 205913003482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913003483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913003484 active site 205913003485 catalytic tetrad [active] 205913003486 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 205913003487 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 205913003488 Predicted membrane protein [Function unknown]; Region: COG4907 205913003489 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 205913003490 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 205913003491 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 205913003492 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 205913003493 Walker A/P-loop; other site 205913003494 ATP binding site [chemical binding]; other site 205913003495 Q-loop/lid; other site 205913003496 ABC transporter signature motif; other site 205913003497 Walker B; other site 205913003498 D-loop; other site 205913003499 H-loop/switch region; other site 205913003500 sulfate transport protein; Provisional; Region: cysT; CHL00187 205913003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003502 dimer interface [polypeptide binding]; other site 205913003503 conserved gate region; other site 205913003504 putative PBP binding loops; other site 205913003505 ABC-ATPase subunit interface; other site 205913003506 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 205913003507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003508 dimer interface [polypeptide binding]; other site 205913003509 conserved gate region; other site 205913003510 putative PBP binding loops; other site 205913003511 ABC-ATPase subunit interface; other site 205913003512 PBP superfamily domain; Region: PBP_like_2; cl17296 205913003513 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913003514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913003515 active site 205913003516 phosphorylation site [posttranslational modification] 205913003517 intermolecular recognition site; other site 205913003518 dimerization interface [polypeptide binding]; other site 205913003519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205913003520 DNA binding site [nucleotide binding] 205913003521 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205913003522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 205913003523 dimer interface [polypeptide binding]; other site 205913003524 phosphorylation site [posttranslational modification] 205913003525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913003526 ATP binding site [chemical binding]; other site 205913003527 Mg2+ binding site [ion binding]; other site 205913003528 G-X-G motif; other site 205913003529 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 205913003530 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 205913003531 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 205913003532 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205913003533 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 205913003534 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 205913003535 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 205913003536 trimer interface [polypeptide binding]; other site 205913003537 active site 205913003538 G bulge; other site 205913003539 DivIVA protein; Region: DivIVA; pfam05103 205913003540 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 205913003541 putative substrate binding pocket [chemical binding]; other site 205913003542 AC domain interface; other site 205913003543 catalytic triad [active] 205913003544 AB domain interface; other site 205913003545 interchain disulfide; other site 205913003546 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 205913003547 substrate binding site; other site 205913003548 dimer interface; other site 205913003549 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 205913003550 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 205913003551 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 205913003552 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 205913003553 Peptidase family U32; Region: Peptidase_U32; pfam01136 205913003554 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 205913003555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913003556 S-adenosylmethionine binding site [chemical binding]; other site 205913003557 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 205913003558 ssDNA binding site; other site 205913003559 generic binding surface II; other site 205913003560 DEAD-like helicases superfamily; Region: DEXDc; smart00487 205913003561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913003562 ATP binding site [chemical binding]; other site 205913003563 putative Mg++ binding site [ion binding]; other site 205913003564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913003565 nucleotide binding region [chemical binding]; other site 205913003566 ATP-binding site [chemical binding]; other site 205913003567 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 205913003568 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 205913003569 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 205913003570 substrate binding site [chemical binding]; other site 205913003571 ATP binding site [chemical binding]; other site 205913003572 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 205913003573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913003574 putative substrate translocation pore; other site 205913003575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205913003576 dimerization interface [polypeptide binding]; other site 205913003577 putative DNA binding site [nucleotide binding]; other site 205913003578 putative Zn2+ binding site [ion binding]; other site 205913003579 Predicted permeases [General function prediction only]; Region: COG0701 205913003580 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 205913003581 Low molecular weight phosphatase family; Region: LMWPc; cl00105 205913003582 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 205913003583 arsenical-resistance protein; Region: acr3; TIGR00832 205913003584 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205913003585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913003586 non-specific DNA binding site [nucleotide binding]; other site 205913003587 salt bridge; other site 205913003588 sequence-specific DNA binding site [nucleotide binding]; other site 205913003589 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 205913003590 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 205913003591 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 205913003592 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 205913003593 DNA binding site [nucleotide binding] 205913003594 active site 205913003595 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 205913003596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 205913003597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003599 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 205913003600 Aspartase; Region: Aspartase; cd01357 205913003601 active sites [active] 205913003602 tetramer interface [polypeptide binding]; other site 205913003603 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 205913003604 Mechanosensitive ion channel; Region: MS_channel; pfam00924 205913003605 CAAX protease self-immunity; Region: Abi; pfam02517 205913003606 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 205913003607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913003608 Walker A/P-loop; other site 205913003609 ATP binding site [chemical binding]; other site 205913003610 Q-loop/lid; other site 205913003611 ABC transporter signature motif; other site 205913003612 Walker B; other site 205913003613 D-loop; other site 205913003614 H-loop/switch region; other site 205913003615 TOBE domain; Region: TOBE_2; pfam08402 205913003616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913003617 dimer interface [polypeptide binding]; other site 205913003618 conserved gate region; other site 205913003619 putative PBP binding loops; other site 205913003620 ABC-ATPase subunit interface; other site 205913003621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 205913003622 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205913003623 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 205913003624 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 205913003625 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 205913003626 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 205913003627 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 205913003628 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 205913003629 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 205913003630 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 205913003631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 205913003632 putative acyl-acceptor binding pocket; other site 205913003633 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 205913003634 homotrimer interaction site [polypeptide binding]; other site 205913003635 putative active site [active] 205913003636 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 205913003637 putative active site [active] 205913003638 putative metal binding residues [ion binding]; other site 205913003639 signature motif; other site 205913003640 putative dimer interface [polypeptide binding]; other site 205913003641 putative phosphate binding site [ion binding]; other site 205913003642 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 205913003643 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 205913003644 hypothetical protein; Provisional; Region: PRK03298 205913003645 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 205913003646 gamma subunit interface [polypeptide binding]; other site 205913003647 epsilon subunit interface [polypeptide binding]; other site 205913003648 LBP interface [polypeptide binding]; other site 205913003649 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 205913003650 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205913003651 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 205913003652 alpha subunit interaction interface [polypeptide binding]; other site 205913003653 Walker A motif; other site 205913003654 ATP binding site [chemical binding]; other site 205913003655 Walker B motif; other site 205913003656 inhibitor binding site; inhibition site 205913003657 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205913003658 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 205913003659 core domain interface [polypeptide binding]; other site 205913003660 delta subunit interface [polypeptide binding]; other site 205913003661 epsilon subunit interface [polypeptide binding]; other site 205913003662 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 205913003663 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 205913003664 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 205913003665 beta subunit interaction interface [polypeptide binding]; other site 205913003666 Walker A motif; other site 205913003667 ATP binding site [chemical binding]; other site 205913003668 Walker B motif; other site 205913003669 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 205913003670 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 205913003671 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 205913003672 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 205913003673 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 205913003674 ATP synthase subunit C; Region: ATP-synt_C; cl00466 205913003675 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 205913003676 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 205913003677 homoserine O-succinyltransferase; Provisional; Region: PRK05368 205913003678 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 205913003679 proposed active site lysine [active] 205913003680 conserved cys residue [active] 205913003681 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913003682 active site 205913003683 DNA binding site [nucleotide binding] 205913003684 Int/Topo IB signature motif; other site 205913003685 Protein of unknown function (DUF497); Region: DUF497; pfam04365 205913003686 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 205913003687 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 205913003688 active site 205913003689 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 205913003690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 205913003691 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 205913003692 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 205913003693 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 205913003694 putative active site [active] 205913003695 putative NTP binding site [chemical binding]; other site 205913003696 putative nucleic acid binding site [nucleotide binding]; other site 205913003697 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 205913003698 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 205913003699 tape measure domain; Region: tape_meas_nterm; TIGR02675 205913003700 membrane protein P6; Region: PHA01399 205913003701 Phage-related protein [Function unknown]; Region: COG5412 205913003702 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 205913003703 Phage capsid family; Region: Phage_capsid; pfam05065 205913003704 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 205913003705 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 205913003706 Phage terminase large subunit; Region: Terminase_3; cl12054 205913003707 Transcription factor WhiB; Region: Whib; pfam02467 205913003708 Repressor of nif and glnA expression [Transcription]; Region: COG1693 205913003709 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 205913003710 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 205913003711 catalytic site [active] 205913003712 putative active site [active] 205913003713 putative substrate binding site [chemical binding]; other site 205913003714 dimer interface [polypeptide binding]; other site 205913003715 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205913003716 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205913003717 dimer interface [polypeptide binding]; other site 205913003718 ssDNA binding site [nucleotide binding]; other site 205913003719 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913003720 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 205913003721 SPFH domain / Band 7 family; Region: Band_7; pfam01145 205913003722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 205913003723 sequence-specific DNA binding site [nucleotide binding]; other site 205913003724 salt bridge; other site 205913003725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913003726 non-specific DNA binding site [nucleotide binding]; other site 205913003727 salt bridge; other site 205913003728 sequence-specific DNA binding site [nucleotide binding]; other site 205913003729 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 205913003730 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 205913003731 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 205913003732 active site 205913003733 homodimer interface [polypeptide binding]; other site 205913003734 catalytic site [active] 205913003735 acceptor binding site [chemical binding]; other site 205913003736 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 205913003737 dimer interface [polypeptide binding]; other site 205913003738 substrate binding site [chemical binding]; other site 205913003739 metal binding sites [ion binding]; metal-binding site 205913003740 Predicted membrane protein [Function unknown]; Region: COG1971 205913003741 Domain of unknown function DUF; Region: DUF204; pfam02659 205913003742 Domain of unknown function DUF; Region: DUF204; pfam02659 205913003743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 205913003744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 205913003745 DNA binding site [nucleotide binding] 205913003746 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 205913003747 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 205913003748 minor groove reading motif; other site 205913003749 helix-hairpin-helix signature motif; other site 205913003750 substrate binding pocket [chemical binding]; other site 205913003751 active site 205913003752 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 205913003753 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 205913003754 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 205913003755 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 205913003756 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913003757 active site 205913003758 HIGH motif; other site 205913003759 nucleotide binding site [chemical binding]; other site 205913003760 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913003761 active site 205913003762 KMSKS motif; other site 205913003763 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 205913003764 tRNA binding surface [nucleotide binding]; other site 205913003765 anticodon binding site; other site 205913003766 monofunctional chorismate mutase, alpha proteobacterial type; Region: CM_mono_cladeE; TIGR01795 205913003767 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 205913003768 transcription termination factor Rho; Provisional; Region: PRK12608 205913003769 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 205913003770 RNA binding site [nucleotide binding]; other site 205913003771 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 205913003772 multimer interface [polypeptide binding]; other site 205913003773 Walker A motif; other site 205913003774 ATP binding site [chemical binding]; other site 205913003775 Walker B motif; other site 205913003776 hypothetical protein; Provisional; Region: PRK07208 205913003777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205913003778 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 205913003779 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 205913003780 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 205913003781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 205913003782 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 205913003783 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 205913003784 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 205913003785 GatB domain; Region: GatB_Yqey; pfam02637 205913003786 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 205913003787 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 205913003788 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 205913003789 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 205913003790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 205913003791 RmuC family; Region: RmuC; pfam02646 205913003792 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 205913003793 putative homodimer interface [polypeptide binding]; other site 205913003794 putative homotetramer interface [polypeptide binding]; other site 205913003795 putative allosteric switch controlling residues; other site 205913003796 putative metal binding site [ion binding]; other site 205913003797 putative homodimer-homodimer interface [polypeptide binding]; other site 205913003798 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 205913003799 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 205913003800 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913003801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913003802 active site 205913003803 motif I; other site 205913003804 motif II; other site 205913003805 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 205913003806 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 205913003807 amphipathic channel; other site 205913003808 Asn-Pro-Ala signature motifs; other site 205913003809 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 205913003810 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 205913003811 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 205913003812 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 205913003813 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 205913003814 dimerization domain swap beta strand [polypeptide binding]; other site 205913003815 regulatory protein interface [polypeptide binding]; other site 205913003816 active site 205913003817 regulatory phosphorylation site [posttranslational modification]; other site 205913003818 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 205913003819 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 205913003820 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 205913003821 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 205913003822 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205913003823 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205913003824 dimer interface [polypeptide binding]; other site 205913003825 ssDNA binding site [nucleotide binding]; other site 205913003826 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913003827 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 205913003828 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 205913003829 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 205913003830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913003831 active site 205913003832 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 205913003833 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205913003834 catalytic residue [active] 205913003835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 205913003836 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 205913003837 Probable transposase; Region: OrfB_IS605; pfam01385 205913003838 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 205913003839 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 205913003840 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 205913003841 catalytic residues [active] 205913003842 catalytic nucleophile [active] 205913003843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913003844 NADH(P)-binding; Region: NAD_binding_10; pfam13460 205913003845 NAD(P) binding site [chemical binding]; other site 205913003846 active site 205913003847 Predicted transcriptional regulators [Transcription]; Region: COG1733 205913003848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 205913003849 dimerization interface [polypeptide binding]; other site 205913003850 putative DNA binding site [nucleotide binding]; other site 205913003851 putative Zn2+ binding site [ion binding]; other site 205913003852 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 205913003853 ABC1 family; Region: ABC1; pfam03109 205913003854 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 205913003855 active site 205913003856 ATP binding site [chemical binding]; other site 205913003857 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 205913003858 Uncharacterized conserved protein [Function unknown]; Region: COG3937 205913003859 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 205913003860 catalytic triad [active] 205913003861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 205913003862 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 205913003863 replicative DNA helicase; Region: DnaB; TIGR00665 205913003864 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 205913003865 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 205913003866 Walker A motif; other site 205913003867 ATP binding site [chemical binding]; other site 205913003868 Walker B motif; other site 205913003869 DNA binding loops [nucleotide binding] 205913003870 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 205913003871 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 205913003872 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 205913003873 metal binding triad; other site 205913003874 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 205913003875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 205913003876 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 205913003877 Nitrogen regulatory protein P-II; Region: P-II; smart00938 205913003878 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 205913003879 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 205913003880 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 205913003881 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205913003882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003884 putative glycosyl transferase; Provisional; Region: PRK10073 205913003885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913003886 active site 205913003887 Peptidase family C69; Region: Peptidase_C69; pfam03577 205913003888 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 205913003889 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 205913003890 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 205913003891 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 205913003892 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 205913003893 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 205913003894 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 205913003895 putative active site [active] 205913003896 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 205913003897 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 205913003898 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 205913003899 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 205913003900 Predicted membrane protein [Function unknown]; Region: COG1511 205913003901 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913003902 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 205913003903 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913003904 Predicted membrane protein [Function unknown]; Region: COG1511 205913003905 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 205913003906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913003907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913003908 FMN-binding domain; Region: FMN_bind; cl01081 205913003909 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913003910 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913003911 Walker A/P-loop; other site 205913003912 ATP binding site [chemical binding]; other site 205913003913 Q-loop/lid; other site 205913003914 ABC transporter signature motif; other site 205913003915 Walker B; other site 205913003916 D-loop; other site 205913003917 H-loop/switch region; other site 205913003918 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 205913003919 FtsX-like permease family; Region: FtsX; pfam02687 205913003920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913003921 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 205913003922 FtsX-like permease family; Region: FtsX; pfam02687 205913003923 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 205913003924 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 205913003925 Fe2+ transport protein; Region: Iron_transport; pfam10634 205913003926 Iron permease FTR1 family; Region: FTR1; cl00475 205913003927 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 205913003928 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 205913003929 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 205913003930 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 205913003931 sugar binding site [chemical binding]; other site 205913003932 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 205913003933 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 205913003934 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205913003935 HIGH motif; other site 205913003936 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 205913003937 active site 205913003938 KMSKS motif; other site 205913003939 Protein of unknown function (DUF805); Region: DUF805; pfam05656 205913003940 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 205913003941 active site 205913003942 phosphate binding residues; other site 205913003943 catalytic residues [active] 205913003944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913003945 catalytic core [active] 205913003946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913003947 Predicted membrane protein [Function unknown]; Region: COG2246 205913003948 GtrA-like protein; Region: GtrA; pfam04138 205913003949 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 205913003950 Helix-turn-helix domain; Region: HTH_38; pfam13936 205913003951 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913003952 Integrase core domain; Region: rve; pfam00665 205913003953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 205913003954 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 205913003955 Peptidase family C69; Region: Peptidase_C69; pfam03577 205913003956 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 205913003957 substrate binding site [chemical binding]; other site 205913003958 DNA polymerase III subunit delta'; Validated; Region: PRK07940 205913003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913003960 Walker A motif; other site 205913003961 ATP binding site [chemical binding]; other site 205913003962 Walker B motif; other site 205913003963 thymidylate kinase; Validated; Region: tmk; PRK00698 205913003964 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 205913003965 TMP-binding site; other site 205913003966 ATP-binding site [chemical binding]; other site 205913003967 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 205913003968 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 205913003969 active site 205913003970 interdomain interaction site; other site 205913003971 putative metal-binding site [ion binding]; other site 205913003972 nucleotide binding site [chemical binding]; other site 205913003973 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 205913003974 domain I; other site 205913003975 phosphate binding site [ion binding]; other site 205913003976 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 205913003977 domain II; other site 205913003978 domain III; other site 205913003979 nucleotide binding site [chemical binding]; other site 205913003980 DNA binding groove [nucleotide binding] 205913003981 catalytic site [active] 205913003982 domain IV; other site 205913003983 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 205913003984 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 205913003985 active site 205913003986 Transglycosylase; Region: Transgly; pfam00912 205913003987 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 205913003988 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 205913003989 2-isopropylmalate synthase; Validated; Region: PRK03739 205913003990 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 205913003991 active site 205913003992 catalytic residues [active] 205913003993 metal binding site [ion binding]; metal-binding site 205913003994 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 205913003995 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913003996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205913003997 metal binding site [ion binding]; metal-binding site 205913003998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 205913003999 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 205913004000 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 205913004001 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 205913004002 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 205913004003 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 205913004004 putative allosteric regulatory site; other site 205913004005 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 205913004006 aspartate kinase; Reviewed; Region: PRK06635 205913004007 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 205913004008 putative nucleotide binding site [chemical binding]; other site 205913004009 putative catalytic residues [active] 205913004010 putative Mg ion binding site [ion binding]; other site 205913004011 putative aspartate binding site [chemical binding]; other site 205913004012 AAA domain; Region: AAA_14; pfam13173 205913004013 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 205913004014 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 205913004015 active site 205913004016 catalytic site [active] 205913004017 recombination protein RecR; Reviewed; Region: recR; PRK00076 205913004018 RecR protein; Region: RecR; pfam02132 205913004019 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 205913004020 putative active site [active] 205913004021 putative metal-binding site [ion binding]; other site 205913004022 tetramer interface [polypeptide binding]; other site 205913004023 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 205913004024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913004025 Walker A motif; other site 205913004026 ATP binding site [chemical binding]; other site 205913004027 Walker B motif; other site 205913004028 arginine finger; other site 205913004029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913004030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913004031 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 205913004032 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 205913004033 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 205913004034 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 205913004035 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 205913004036 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 205913004037 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 205913004038 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205913004039 ATP binding site [chemical binding]; other site 205913004040 Walker B motif; other site 205913004041 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 205913004042 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 205913004043 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205913004044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004046 DNA binding site [nucleotide binding] 205913004047 domain linker motif; other site 205913004048 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004049 dimerization interface [polypeptide binding]; other site 205913004050 ligand binding site [chemical binding]; other site 205913004051 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913004053 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 205913004054 active site 205913004055 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004057 dimer interface [polypeptide binding]; other site 205913004058 conserved gate region; other site 205913004059 putative PBP binding loops; other site 205913004060 ABC-ATPase subunit interface; other site 205913004061 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913004062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004063 dimer interface [polypeptide binding]; other site 205913004064 conserved gate region; other site 205913004065 putative PBP binding loops; other site 205913004066 ABC-ATPase subunit interface; other site 205913004067 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 205913004068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913004069 motif II; other site 205913004070 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 205913004071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913004072 NAD(P) binding site [chemical binding]; other site 205913004073 active site 205913004074 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 205913004075 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 205913004076 putative catalytic cysteine [active] 205913004077 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 205913004078 xanthine permease; Region: pbuX; TIGR03173 205913004079 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 205913004080 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 205913004081 DNA binding residues [nucleotide binding] 205913004082 putative dimer interface [polypeptide binding]; other site 205913004083 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 205913004084 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 205913004085 HSP70 interaction site [polypeptide binding]; other site 205913004086 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 205913004087 substrate binding site [polypeptide binding]; other site 205913004088 dimer interface [polypeptide binding]; other site 205913004089 GrpE; Region: GrpE; pfam01025 205913004090 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 205913004091 dimer interface [polypeptide binding]; other site 205913004092 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 205913004093 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205913004094 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913004095 nucleotide binding site [chemical binding]; other site 205913004096 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 205913004097 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 205913004098 putative active site [active] 205913004099 putative catalytic site [active] 205913004100 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004102 ABC-ATPase subunit interface; other site 205913004103 putative PBP binding loops; other site 205913004104 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004105 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004106 DNA binding site [nucleotide binding] 205913004107 domain linker motif; other site 205913004108 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004109 ligand binding site [chemical binding]; other site 205913004110 dimerization interface [polypeptide binding]; other site 205913004111 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 205913004112 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 205913004113 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 205913004114 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 205913004115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004117 DNA binding site [nucleotide binding] 205913004118 domain linker motif; other site 205913004119 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004120 ligand binding site [chemical binding]; other site 205913004121 dimerization interface [polypeptide binding]; other site 205913004122 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 205913004123 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 205913004124 active site 205913004125 catalytic site [active] 205913004126 MarR family; Region: MarR_2; cl17246 205913004127 ketol-acid reductoisomerase; Provisional; Region: PRK05479 205913004128 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 205913004129 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 205913004130 ketol-acid reductoisomerase; Provisional; Region: PRK05479 205913004131 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 205913004132 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 205913004133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004134 metabolite-proton symporter; Region: 2A0106; TIGR00883 205913004135 putative substrate translocation pore; other site 205913004136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004138 DNA binding site [nucleotide binding] 205913004139 domain linker motif; other site 205913004140 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 205913004141 dimerization interface [polypeptide binding]; other site 205913004142 ligand binding site [chemical binding]; other site 205913004143 sodium binding site [ion binding]; other site 205913004144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913004145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004146 sucrose phosphorylase; Provisional; Region: PRK13840 205913004147 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 205913004148 active site 205913004149 homodimer interface [polypeptide binding]; other site 205913004150 catalytic site [active] 205913004151 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 205913004152 Helix-turn-helix domain; Region: HTH_28; pfam13518 205913004153 Winged helix-turn helix; Region: HTH_29; pfam13551 205913004154 HTH-like domain; Region: HTH_21; pfam13276 205913004155 Integrase core domain; Region: rve; pfam00665 205913004156 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913004157 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913004158 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 205913004159 Int/Topo IB signature motif; other site 205913004160 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913004161 Int/Topo IB signature motif; other site 205913004162 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 205913004163 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913004164 active site 205913004165 DNA binding site [nucleotide binding] 205913004166 Int/Topo IB signature motif; other site 205913004167 Integrase core domain; Region: rve_2; pfam13333 205913004168 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 205913004169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004171 DNA binding site [nucleotide binding] 205913004172 domain linker motif; other site 205913004173 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004174 dimerization interface [polypeptide binding]; other site 205913004175 ligand binding site [chemical binding]; other site 205913004176 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913004177 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 205913004178 K+ potassium transporter; Region: K_trans; cl15781 205913004179 K+ potassium transporter; Region: K_trans; pfam02705 205913004180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004182 DNA binding site [nucleotide binding] 205913004183 domain linker motif; other site 205913004184 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 205913004185 CrcB-like protein; Region: CRCB; pfam02537 205913004186 CrcB-like protein; Region: CRCB; pfam02537 205913004187 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 205913004188 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 205913004189 Cl- selectivity filter; other site 205913004190 Cl- binding residues [ion binding]; other site 205913004191 pore gating glutamate residue; other site 205913004192 dimer interface [polypeptide binding]; other site 205913004193 H+/Cl- coupling transport residue; other site 205913004194 TrkA-C domain; Region: TrkA_C; pfam02080 205913004195 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 205913004196 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 205913004197 GDP-binding site [chemical binding]; other site 205913004198 ACT binding site; other site 205913004199 IMP binding site; other site 205913004200 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 205913004201 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 205913004202 active site 205913004203 intersubunit interface [polypeptide binding]; other site 205913004204 zinc binding site [ion binding]; other site 205913004205 Na+ binding site [ion binding]; other site 205913004206 heat shock protein HtpX; Provisional; Region: PRK03072 205913004207 ferredoxin-NADP+ reductase; Region: PLN02852 205913004208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205913004209 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 205913004210 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 205913004211 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913004212 Soluble P-type ATPase [General function prediction only]; Region: COG4087 205913004213 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 205913004214 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 205913004215 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 205913004216 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 205913004217 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 205913004218 Haemolysin-III related; Region: HlyIII; pfam03006 205913004219 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 205913004220 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 205913004221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913004222 Coenzyme A binding pocket [chemical binding]; other site 205913004223 hypothetical protein; Provisional; Region: PRK01119 205913004224 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 205913004225 putative DNA-binding cleft [nucleotide binding]; other site 205913004226 putative DNA clevage site; other site 205913004227 molecular lever; other site 205913004228 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 205913004229 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 205913004230 cofactor binding site; other site 205913004231 DNA binding site [nucleotide binding] 205913004232 substrate interaction site [chemical binding]; other site 205913004233 HNH endonuclease; Region: HNH_2; pfam13391 205913004234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913004235 active site 205913004236 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 205913004237 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 205913004238 methionine sulfoxide reductase B; Provisional; Region: PRK00222 205913004239 SelR domain; Region: SelR; pfam01641 205913004240 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 205913004241 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 205913004242 Putative esterase; Region: Esterase; pfam00756 205913004243 aromatic amino acid exporter; Provisional; Region: PRK11689 205913004244 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 205913004245 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 205913004246 putative dimer interface [polypeptide binding]; other site 205913004247 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 205913004248 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205913004249 metal ion-dependent adhesion site (MIDAS); other site 205913004250 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 205913004251 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 205913004252 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 205913004253 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 205913004254 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205913004255 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 205913004256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913004257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 205913004258 phosphopeptide binding site; other site 205913004259 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913004260 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 205913004261 phosphopeptide binding site; other site 205913004262 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 205913004263 active site 205913004264 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 205913004265 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 205913004266 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913004267 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913004268 active site 205913004269 ATP binding site [chemical binding]; other site 205913004270 substrate binding site [chemical binding]; other site 205913004271 activation loop (A-loop); other site 205913004272 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 205913004273 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913004274 active site 205913004275 ATP binding site [chemical binding]; other site 205913004276 substrate binding site [chemical binding]; other site 205913004277 activation loop (A-loop); other site 205913004278 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 205913004279 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 205913004280 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 205913004281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 205913004282 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 205913004283 Glutamine amidotransferase class-I; Region: GATase; pfam00117 205913004284 glutamine binding [chemical binding]; other site 205913004285 catalytic triad [active] 205913004286 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 205913004287 active site 205913004288 catalytic site [active] 205913004289 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 205913004290 putative septation inhibitor protein; Reviewed; Region: PRK02251 205913004291 Rhomboid family; Region: Rhomboid; pfam01694 205913004292 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 205913004293 homodimer interface [polypeptide binding]; other site 205913004294 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 205913004295 active site pocket [active] 205913004296 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 205913004297 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 205913004298 active site 205913004299 HIGH motif; other site 205913004300 dimer interface [polypeptide binding]; other site 205913004301 KMSKS motif; other site 205913004302 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 205913004303 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 205913004304 active site 205913004305 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 205913004306 Na binding site [ion binding]; other site 205913004307 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 205913004308 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 205913004309 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 205913004310 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 205913004311 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 205913004312 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913004313 Divergent AAA domain; Region: AAA_4; pfam04326 205913004314 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205913004315 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 205913004316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004318 DNA binding site [nucleotide binding] 205913004319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004320 dimerization interface [polypeptide binding]; other site 205913004321 ligand binding site [chemical binding]; other site 205913004322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913004324 putative substrate translocation pore; other site 205913004325 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 205913004326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205913004327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205913004328 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 205913004329 catalytic residue [active] 205913004330 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 205913004331 catalytic residues [active] 205913004332 peroxiredoxin; Region: AhpC; TIGR03137 205913004333 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 205913004334 dimer interface [polypeptide binding]; other site 205913004335 decamer (pentamer of dimers) interface [polypeptide binding]; other site 205913004336 catalytic triad [active] 205913004337 peroxidatic and resolving cysteines [active] 205913004338 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 205913004339 active site clefts [active] 205913004340 zinc binding site [ion binding]; other site 205913004341 dimer interface [polypeptide binding]; other site 205913004342 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 205913004343 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 205913004344 Domain of unknown function DUF21; Region: DUF21; pfam01595 205913004345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 205913004346 Transporter associated domain; Region: CorC_HlyC; smart01091 205913004347 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 205913004348 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 205913004349 dimerization interface [polypeptide binding]; other site 205913004350 DPS ferroxidase diiron center [ion binding]; other site 205913004351 ion pore; other site 205913004352 AAA domain; Region: AAA_14; pfam13173 205913004353 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 205913004354 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 205913004355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913004356 DNA-binding interface [nucleotide binding]; DNA binding site 205913004357 Integrase core domain; Region: rve; pfam00665 205913004358 transposase/IS protein; Provisional; Region: PRK09183 205913004359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913004360 Walker A motif; other site 205913004361 ATP binding site [chemical binding]; other site 205913004362 Walker B motif; other site 205913004363 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 205913004364 Protein of unknown function DUF45; Region: DUF45; pfam01863 205913004365 hypothetical protein; Provisional; Region: PRK06062 205913004366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 205913004367 inhibitor-cofactor binding pocket; inhibition site 205913004368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004369 catalytic residue [active] 205913004370 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 205913004371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 205913004372 DNA-binding site [nucleotide binding]; DNA binding site 205913004373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004375 homodimer interface [polypeptide binding]; other site 205913004376 catalytic residue [active] 205913004377 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205913004378 aspartate aminotransferase; Provisional; Region: PRK05764 205913004379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004381 homodimer interface [polypeptide binding]; other site 205913004382 catalytic residue [active] 205913004383 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 205913004384 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 205913004385 putative DNA binding site [nucleotide binding]; other site 205913004386 putative Zn2+ binding site [ion binding]; other site 205913004387 AsnC family; Region: AsnC_trans_reg; pfam01037 205913004388 glutamate dehydrogenase; Provisional; Region: PRK09414 205913004389 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 205913004390 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 205913004391 NAD(P) binding site [chemical binding]; other site 205913004392 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 205913004393 AAA domain; Region: AAA_14; pfam13173 205913004394 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 205913004395 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 205913004396 DNA gyrase subunit A; Validated; Region: PRK05560 205913004397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 205913004398 CAP-like domain; other site 205913004399 active site 205913004400 primary dimer interface [polypeptide binding]; other site 205913004401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 205913004407 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 205913004408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913004409 Mg2+ binding site [ion binding]; other site 205913004410 G-X-G motif; other site 205913004411 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 205913004412 anchoring element; other site 205913004413 dimer interface [polypeptide binding]; other site 205913004414 ATP binding site [chemical binding]; other site 205913004415 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 205913004416 active site 205913004417 putative metal-binding site [ion binding]; other site 205913004418 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 205913004419 Protein of unknown function (DUF721); Region: DUF721; pfam05258 205913004420 recombination protein F; Reviewed; Region: recF; PRK00064 205913004421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913004422 Walker A/P-loop; other site 205913004423 ATP binding site [chemical binding]; other site 205913004424 Q-loop/lid; other site 205913004425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913004426 ABC transporter signature motif; other site 205913004427 Walker B; other site 205913004428 D-loop; other site 205913004429 H-loop/switch region; other site 205913004430 DNA polymerase III subunit beta; Validated; Region: PRK07761 205913004431 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 205913004432 putative DNA binding surface [nucleotide binding]; other site 205913004433 dimer interface [polypeptide binding]; other site 205913004434 beta-clamp/clamp loader binding surface; other site 205913004435 beta-clamp/translesion DNA polymerase binding surface; other site 205913004436 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 205913004437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913004438 Walker A motif; other site 205913004439 ATP binding site [chemical binding]; other site 205913004440 Walker B motif; other site 205913004441 arginine finger; other site 205913004442 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 205913004443 DnaA box-binding interface [nucleotide binding]; other site 205913004444 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 205913004445 Ribonuclease P; Region: Ribonuclease_P; pfam00825 205913004446 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 205913004447 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 205913004448 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 205913004449 G-X-X-G motif; other site 205913004450 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 205913004451 RxxxH motif; other site 205913004452 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 205913004453 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 205913004454 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 205913004455 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913004456 P-loop; other site 205913004457 Magnesium ion binding site [ion binding]; other site 205913004458 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913004459 Magnesium ion binding site [ion binding]; other site 205913004460 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 205913004461 ParB-like nuclease domain; Region: ParBc; pfam02195 205913004462 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 205913004463 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 205913004464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205913004465 integral membrane protein MviN; Region: mviN; TIGR01695 205913004466 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 205913004467 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 205913004468 active site 205913004469 Ap6A binding site [chemical binding]; other site 205913004470 nudix motif; other site 205913004471 metal binding site [ion binding]; metal-binding site 205913004472 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 205913004473 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 205913004474 active site 205913004475 NTP binding site [chemical binding]; other site 205913004476 metal binding triad [ion binding]; metal-binding site 205913004477 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 205913004478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205913004479 Zn2+ binding site [ion binding]; other site 205913004480 Mg2+ binding site [ion binding]; other site 205913004481 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 205913004482 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 205913004483 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 205913004484 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 205913004485 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 205913004486 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 205913004487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 205913004488 Domain of unknown function (DUF348); Region: DUF348; pfam03990 205913004489 G5 domain; Region: G5; pfam07501 205913004490 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205913004491 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205913004492 catalytic residue [active] 205913004493 Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227 205913004494 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 205913004495 Catalytic domain of Protein Kinases; Region: PKc; cd00180 205913004496 active site 205913004497 ATP binding site [chemical binding]; other site 205913004498 substrate binding site [chemical binding]; other site 205913004499 activation loop (A-loop); other site 205913004500 AAA ATPase domain; Region: AAA_16; pfam13191 205913004501 Ion channel; Region: Ion_trans_2; pfam07885 205913004502 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 205913004503 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 205913004504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913004505 non-specific DNA binding site [nucleotide binding]; other site 205913004506 salt bridge; other site 205913004507 sequence-specific DNA binding site [nucleotide binding]; other site 205913004508 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 205913004509 catalytic residues [active] 205913004510 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 205913004511 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 205913004512 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 205913004513 Class I ribonucleotide reductase; Region: RNR_I; cd01679 205913004514 active site 205913004515 dimer interface [polypeptide binding]; other site 205913004516 catalytic residues [active] 205913004517 effector binding site; other site 205913004518 R2 peptide binding site; other site 205913004519 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 205913004520 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 205913004521 dimer interface [polypeptide binding]; other site 205913004522 putative radical transfer pathway; other site 205913004523 diiron center [ion binding]; other site 205913004524 tyrosyl radical; other site 205913004525 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913004526 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 205913004527 active site 205913004528 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 205913004529 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 205913004530 Walker A/P-loop; other site 205913004531 ATP binding site [chemical binding]; other site 205913004532 Q-loop/lid; other site 205913004533 ABC transporter signature motif; other site 205913004534 Walker B; other site 205913004535 D-loop; other site 205913004536 H-loop/switch region; other site 205913004537 TOBE domain; Region: TOBE_2; pfam08402 205913004538 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 205913004539 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 205913004540 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 205913004541 active site 205913004542 catalytic site [active] 205913004543 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 205913004544 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 205913004545 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 205913004546 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 205913004547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913004549 putative substrate translocation pore; other site 205913004550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004551 putative substrate translocation pore; other site 205913004552 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913004553 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205913004554 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 205913004555 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 205913004556 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 205913004557 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 205913004558 Soluble P-type ATPase [General function prediction only]; Region: COG4087 205913004559 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 205913004560 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 205913004561 trimer interface [polypeptide binding]; other site 205913004562 active site 205913004563 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 205913004564 Serine hydrolase (FSH1); Region: FSH1; pfam03959 205913004565 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 205913004566 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 205913004567 nucleoside/Zn binding site; other site 205913004568 dimer interface [polypeptide binding]; other site 205913004569 catalytic motif [active] 205913004570 Melibiase; Region: Melibiase; pfam02065 205913004571 MarR family; Region: MarR_2; pfam12802 205913004572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 205913004573 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913004574 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913004575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913004576 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205913004577 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913004578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004579 dimer interface [polypeptide binding]; other site 205913004580 conserved gate region; other site 205913004581 putative PBP binding loops; other site 205913004582 ABC-ATPase subunit interface; other site 205913004583 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004585 dimer interface [polypeptide binding]; other site 205913004586 conserved gate region; other site 205913004587 putative PBP binding loops; other site 205913004588 ABC-ATPase subunit interface; other site 205913004589 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004590 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004591 DNA binding site [nucleotide binding] 205913004592 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004593 ligand binding site [chemical binding]; other site 205913004594 dimerization interface [polypeptide binding]; other site 205913004595 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004596 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004597 dimerization interface [polypeptide binding]; other site 205913004598 ligand binding site [chemical binding]; other site 205913004599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913004601 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 205913004602 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004603 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913004604 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 205913004605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004606 dimer interface [polypeptide binding]; other site 205913004607 conserved gate region; other site 205913004608 putative PBP binding loops; other site 205913004609 ABC-ATPase subunit interface; other site 205913004610 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004612 dimer interface [polypeptide binding]; other site 205913004613 conserved gate region; other site 205913004614 putative PBP binding loops; other site 205913004615 ABC-ATPase subunit interface; other site 205913004616 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 205913004617 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 205913004618 active site 205913004619 catalytic site [active] 205913004620 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 205913004621 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 205913004622 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 205913004623 Ca binding site [ion binding]; other site 205913004624 active site 205913004625 catalytic site [active] 205913004626 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 205913004627 tetramer interface [polypeptide binding]; other site 205913004628 threonine dehydratase; Provisional; Region: PRK08198 205913004629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004630 catalytic residue [active] 205913004631 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 205913004632 NAD-dependent deacetylase; Provisional; Region: PRK00481 205913004633 SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410 205913004634 NAD+ binding site [chemical binding]; other site 205913004635 substrate binding site [chemical binding]; other site 205913004636 Zn binding site [ion binding]; other site 205913004637 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913004638 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 205913004639 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 205913004640 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 205913004641 Predicted membrane protein [Function unknown]; Region: COG1511 205913004642 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 205913004643 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 205913004644 dimer interface [polypeptide binding]; other site 205913004645 FMN binding site [chemical binding]; other site 205913004646 NADPH bind site [chemical binding]; other site 205913004647 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 205913004648 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913004649 catalytic core [active] 205913004650 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 205913004651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004653 DNA binding site [nucleotide binding] 205913004654 domain linker motif; other site 205913004655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004656 ligand binding site [chemical binding]; other site 205913004657 dimerization interface [polypeptide binding]; other site 205913004658 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 205913004659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004660 putative PBP binding loops; other site 205913004661 dimer interface [polypeptide binding]; other site 205913004662 ABC-ATPase subunit interface; other site 205913004663 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004665 dimer interface [polypeptide binding]; other site 205913004666 conserved gate region; other site 205913004667 putative PBP binding loops; other site 205913004668 ABC-ATPase subunit interface; other site 205913004669 Protein of unknown function, DUF624; Region: DUF624; pfam04854 205913004670 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 205913004671 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 205913004672 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 205913004673 active site 205913004674 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 205913004675 AAA domain; Region: AAA_14; pfam13173 205913004676 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 205913004677 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 205913004678 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 205913004679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913004680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913004681 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 205913004682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913004683 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913004684 Walker A/P-loop; other site 205913004685 ATP binding site [chemical binding]; other site 205913004686 Q-loop/lid; other site 205913004687 ABC transporter signature motif; other site 205913004688 Walker B; other site 205913004689 D-loop; other site 205913004690 H-loop/switch region; other site 205913004691 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 205913004692 FtsX-like permease family; Region: FtsX; pfam02687 205913004693 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 205913004694 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 205913004695 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913004696 Divergent AAA domain; Region: AAA_4; pfam04326 205913004697 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205913004698 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 205913004699 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 205913004700 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 205913004701 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 205913004702 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 205913004703 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913004704 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 205913004705 active site 205913004706 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913004707 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 205913004708 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 205913004709 BRO family, N-terminal domain; Region: Bro-N; pfam02498 205913004710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205913004711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913004713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913004714 Walker A/P-loop; other site 205913004715 ATP binding site [chemical binding]; other site 205913004716 Q-loop/lid; other site 205913004717 ABC transporter signature motif; other site 205913004718 Walker B; other site 205913004719 D-loop; other site 205913004720 H-loop/switch region; other site 205913004721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913004723 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 205913004724 Walker A/P-loop; other site 205913004725 ATP binding site [chemical binding]; other site 205913004726 Q-loop/lid; other site 205913004727 ABC transporter signature motif; other site 205913004728 Walker B; other site 205913004729 D-loop; other site 205913004730 H-loop/switch region; other site 205913004731 ApbE family; Region: ApbE; pfam02424 205913004732 MFS/sugar transport protein; Region: MFS_2; pfam13347 205913004733 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 205913004734 Predicted methyltransferases [General function prediction only]; Region: COG0313 205913004735 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 205913004736 putative SAM binding site [chemical binding]; other site 205913004737 putative homodimer interface [polypeptide binding]; other site 205913004738 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 205913004739 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 205913004740 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 205913004741 active site 205913004742 HIGH motif; other site 205913004743 KMSKS motif; other site 205913004744 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 205913004745 tRNA binding surface [nucleotide binding]; other site 205913004746 anticodon binding site; other site 205913004747 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 205913004748 trimer interface [polypeptide binding]; other site 205913004749 active site 205913004750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 205913004751 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 205913004752 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 205913004753 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 205913004754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205913004755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004757 DNA binding site [nucleotide binding] 205913004758 domain linker motif; other site 205913004759 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004760 dimerization interface [polypeptide binding]; other site 205913004761 ligand binding site [chemical binding]; other site 205913004762 alpha-galactosidase; Region: PLN02808; cl17638 205913004763 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913004765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913004766 Walker A/P-loop; other site 205913004767 ATP binding site [chemical binding]; other site 205913004768 Q-loop/lid; other site 205913004769 ABC transporter signature motif; other site 205913004770 Walker B; other site 205913004771 D-loop; other site 205913004772 H-loop/switch region; other site 205913004773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913004774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913004775 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 205913004776 Walker A/P-loop; other site 205913004777 ATP binding site [chemical binding]; other site 205913004778 Q-loop/lid; other site 205913004779 ABC transporter signature motif; other site 205913004780 Walker B; other site 205913004781 D-loop; other site 205913004782 H-loop/switch region; other site 205913004783 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 205913004784 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 205913004785 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 205913004786 substrate binding site [chemical binding]; other site 205913004787 active site 205913004788 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 205913004789 substrate binding site [chemical binding]; other site 205913004790 active site 205913004791 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 205913004792 active site 205913004793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913004794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913004795 DNA binding site [nucleotide binding] 205913004796 domain linker motif; other site 205913004797 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913004798 dimerization interface [polypeptide binding]; other site 205913004799 ligand binding site [chemical binding]; other site 205913004800 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913004801 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 205913004802 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 205913004803 active site 205913004804 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913004805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913004806 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913004807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004808 dimer interface [polypeptide binding]; other site 205913004809 conserved gate region; other site 205913004810 putative PBP binding loops; other site 205913004811 ABC-ATPase subunit interface; other site 205913004812 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913004813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913004814 dimer interface [polypeptide binding]; other site 205913004815 conserved gate region; other site 205913004816 putative PBP binding loops; other site 205913004817 ABC-ATPase subunit interface; other site 205913004818 Fic family protein [Function unknown]; Region: COG3177 205913004819 Fic/DOC family; Region: Fic; pfam02661 205913004820 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 205913004821 active site 205913004822 K+ potassium transporter; Region: K_trans; pfam02705 205913004823 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 205913004824 putative active site [active] 205913004825 putative dimer interface [polypeptide binding]; other site 205913004826 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 205913004827 Zn2+ binding site [ion binding]; other site 205913004828 Mg2+ binding site [ion binding]; other site 205913004829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913004830 ABC transporter; Region: ABC_tran; pfam00005 205913004831 Q-loop/lid; other site 205913004832 ABC transporter signature motif; other site 205913004833 Walker B; other site 205913004834 D-loop; other site 205913004835 H-loop/switch region; other site 205913004836 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 205913004837 FtsX-like permease family; Region: FtsX; pfam02687 205913004838 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 205913004839 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 205913004840 Acyltransferase family; Region: Acyl_transf_3; pfam01757 205913004841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 205913004842 Transposase; Region: DDE_Tnp_ISL3; pfam01610 205913004843 Sulfatase; Region: Sulfatase; pfam00884 205913004844 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 205913004845 Ligand binding site; other site 205913004846 Putative Catalytic site; other site 205913004847 DXD motif; other site 205913004848 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 205913004849 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 205913004850 NAD binding site [chemical binding]; other site 205913004851 substrate binding site [chemical binding]; other site 205913004852 homodimer interface [polypeptide binding]; other site 205913004853 active site 205913004854 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 205913004855 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 205913004856 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 205913004857 NADP binding site [chemical binding]; other site 205913004858 active site 205913004859 putative substrate binding site [chemical binding]; other site 205913004860 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 205913004861 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 205913004862 substrate binding site; other site 205913004863 tetramer interface; other site 205913004864 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 205913004865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913004866 active site 205913004867 Rhamnan synthesis protein F; Region: RgpF; pfam05045 205913004868 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 205913004869 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 205913004870 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 205913004871 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 205913004872 Walker A/P-loop; other site 205913004873 ATP binding site [chemical binding]; other site 205913004874 Q-loop/lid; other site 205913004875 ABC transporter signature motif; other site 205913004876 Walker B; other site 205913004877 D-loop; other site 205913004878 H-loop/switch region; other site 205913004879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 205913004880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 205913004881 Sulfatase; Region: Sulfatase; pfam00884 205913004882 putative glycosyl transferase; Provisional; Region: PRK10073 205913004883 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913004884 active site 205913004885 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 205913004886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 205913004887 UDP-galactopyranose mutase; Region: GLF; pfam03275 205913004888 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 205913004889 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 205913004890 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 205913004891 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913004892 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 205913004893 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913004894 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 205913004895 active sites [active] 205913004896 tetramer interface [polypeptide binding]; other site 205913004897 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 205913004898 Clp amino terminal domain; Region: Clp_N; pfam02861 205913004899 Clp amino terminal domain; Region: Clp_N; pfam02861 205913004900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913004901 Walker A motif; other site 205913004902 ATP binding site [chemical binding]; other site 205913004903 Walker B motif; other site 205913004904 arginine finger; other site 205913004905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913004906 Walker A motif; other site 205913004907 ATP binding site [chemical binding]; other site 205913004908 Walker B motif; other site 205913004909 arginine finger; other site 205913004910 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 205913004911 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 205913004912 active site 205913004913 HIGH motif; other site 205913004914 nucleotide binding site [chemical binding]; other site 205913004915 active site 205913004916 KMSKS motif; other site 205913004917 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 205913004918 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 205913004919 active site 205913004920 catalytic site [active] 205913004921 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 205913004922 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913004923 active site 205913004924 AAA domain; Region: AAA_14; pfam13173 205913004925 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 205913004926 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 205913004927 active site 205913004928 Ap6A binding site [chemical binding]; other site 205913004929 nudix motif; other site 205913004930 metal binding site [ion binding]; metal-binding site 205913004931 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913004932 catalytic core [active] 205913004933 polyphosphate kinase; Provisional; Region: PRK05443 205913004934 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 205913004935 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 205913004936 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 205913004937 putative domain interface [polypeptide binding]; other site 205913004938 putative active site [active] 205913004939 catalytic site [active] 205913004940 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 205913004941 putative domain interface [polypeptide binding]; other site 205913004942 putative active site [active] 205913004943 catalytic site [active] 205913004944 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 205913004945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 205913004946 putative active site [active] 205913004947 putative metal binding site [ion binding]; other site 205913004948 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 205913004949 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 205913004950 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913004951 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913004952 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 205913004953 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 205913004954 substrate binding site [chemical binding]; other site 205913004955 ligand binding site [chemical binding]; other site 205913004956 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 205913004957 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 205913004958 substrate binding site [chemical binding]; other site 205913004959 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 205913004960 active site 205913004961 FMN binding site [chemical binding]; other site 205913004962 substrate binding site [chemical binding]; other site 205913004963 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 205913004964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205913004965 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205913004966 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 205913004967 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 205913004968 hinge; other site 205913004969 active site 205913004970 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 205913004971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913004972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913004973 homodimer interface [polypeptide binding]; other site 205913004974 catalytic residue [active] 205913004975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 205913004976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 205913004977 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 205913004978 putative dimerization interface [polypeptide binding]; other site 205913004979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913004980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913004981 putative substrate translocation pore; other site 205913004982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913004983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913004984 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 205913004985 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 205913004986 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 205913004987 active site 205913004988 HIGH motif; other site 205913004989 nucleotide binding site [chemical binding]; other site 205913004990 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 205913004991 KMSK motif region; other site 205913004992 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 205913004993 tRNA binding surface [nucleotide binding]; other site 205913004994 anticodon binding site; other site 205913004995 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 205913004996 catalytic residue [active] 205913004997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 205913004998 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 205913004999 homoserine dehydrogenase; Provisional; Region: PRK06349 205913005000 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 205913005001 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 205913005002 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 205913005003 homoserine kinase; Provisional; Region: PRK01212 205913005004 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 205913005005 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 205913005006 putative active site [active] 205913005007 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 205913005008 dimer interface [polypeptide binding]; other site 205913005009 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 205913005010 nudix motif; other site 205913005011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 205913005012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 205913005013 Walker A/P-loop; other site 205913005014 ATP binding site [chemical binding]; other site 205913005015 Q-loop/lid; other site 205913005016 ABC transporter signature motif; other site 205913005017 Walker B; other site 205913005018 D-loop; other site 205913005019 H-loop/switch region; other site 205913005020 Predicted permeases [General function prediction only]; Region: COG0679 205913005021 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 205913005022 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 205913005023 metal binding site [ion binding]; metal-binding site 205913005024 putative dimer interface [polypeptide binding]; other site 205913005025 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 205913005026 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 205913005027 homodimer interface [polypeptide binding]; other site 205913005028 oligonucleotide binding site [chemical binding]; other site 205913005029 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 205913005030 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 205913005031 GTPase CgtA; Reviewed; Region: obgE; PRK12296 205913005032 GTP1/OBG; Region: GTP1_OBG; pfam01018 205913005033 Obg GTPase; Region: Obg; cd01898 205913005034 G1 box; other site 205913005035 GTP/Mg2+ binding site [chemical binding]; other site 205913005036 Switch I region; other site 205913005037 G2 box; other site 205913005038 G3 box; other site 205913005039 Switch II region; other site 205913005040 G4 box; other site 205913005041 G5 box; other site 205913005042 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 205913005043 gamma-glutamyl kinase; Provisional; Region: PRK05429 205913005044 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 205913005045 nucleotide binding site [chemical binding]; other site 205913005046 homotetrameric interface [polypeptide binding]; other site 205913005047 putative phosphate binding site [ion binding]; other site 205913005048 putative allosteric binding site; other site 205913005049 PUA domain; Region: PUA; pfam01472 205913005050 aspartate aminotransferase; Provisional; Region: PRK05764 205913005051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913005052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913005053 homodimer interface [polypeptide binding]; other site 205913005054 catalytic residue [active] 205913005055 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 205913005056 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 205913005057 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 205913005058 putative homodimer interface [polypeptide binding]; other site 205913005059 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 205913005060 heterodimer interface [polypeptide binding]; other site 205913005061 homodimer interface [polypeptide binding]; other site 205913005062 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 205913005063 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 205913005064 23S rRNA interface [nucleotide binding]; other site 205913005065 L7/L12 interface [polypeptide binding]; other site 205913005066 putative thiostrepton binding site; other site 205913005067 L25 interface [polypeptide binding]; other site 205913005068 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 205913005069 mRNA/rRNA interface [nucleotide binding]; other site 205913005070 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 205913005071 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913005072 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913005073 Transcriptional regulator [Transcription]; Region: IclR; COG1414 205913005074 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 205913005075 Bacterial transcriptional regulator; Region: IclR; pfam01614 205913005076 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 205913005077 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 205913005078 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 205913005079 BioY family; Region: BioY; pfam02632 205913005080 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 205913005081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 205913005082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 205913005083 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 205913005084 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 205913005085 carboxyltransferase (CT) interaction site; other site 205913005086 biotinylation site [posttranslational modification]; other site 205913005087 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 205913005088 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 205913005089 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 205913005090 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 205913005091 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 205913005092 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 205913005093 phosphate binding site [ion binding]; other site 205913005094 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 205913005095 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 205913005096 putative active site [active] 205913005097 putative catalytic site [active] 205913005098 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 205913005099 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 205913005100 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 205913005101 putative NAD(P) binding site [chemical binding]; other site 205913005102 active site 205913005103 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 205913005104 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 205913005105 active site 205913005106 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 205913005107 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 205913005108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205913005109 metal ion-dependent adhesion site (MIDAS); other site 205913005110 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 205913005111 domain interaction interfaces [polypeptide binding]; other site 205913005112 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913005113 Integrase core domain; Region: rve; pfam00665 205913005114 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 205913005115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913005116 Integrase core domain; Region: rve; pfam00665 205913005117 transposase; Provisional; Region: PRK06526 205913005118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005119 Walker A motif; other site 205913005120 ATP binding site [chemical binding]; other site 205913005121 Walker B motif; other site 205913005122 Helix-turn-helix domain; Region: HTH_38; pfam13936 205913005123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913005124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913005125 active site 205913005126 phosphorylation site [posttranslational modification] 205913005127 intermolecular recognition site; other site 205913005128 dimerization interface [polypeptide binding]; other site 205913005129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205913005130 DNA binding residues [nucleotide binding] 205913005131 dimerization interface [polypeptide binding]; other site 205913005132 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 205913005133 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 205913005134 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 205913005135 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 205913005136 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 205913005137 active site 205913005138 zinc binding site [ion binding]; other site 205913005139 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 205913005140 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 205913005141 Walker A/P-loop; other site 205913005142 ATP binding site [chemical binding]; other site 205913005143 Q-loop/lid; other site 205913005144 ABC transporter signature motif; other site 205913005145 Walker B; other site 205913005146 D-loop; other site 205913005147 H-loop/switch region; other site 205913005148 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 205913005149 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 205913005150 putative active site [active] 205913005151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913005152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913005153 Walker A/P-loop; other site 205913005154 ATP binding site [chemical binding]; other site 205913005155 Q-loop/lid; other site 205913005156 ABC transporter signature motif; other site 205913005157 Walker B; other site 205913005158 D-loop; other site 205913005159 H-loop/switch region; other site 205913005160 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 205913005161 Integrase core domain; Region: rve; pfam00665 205913005162 Integrase core domain; Region: rve_3; cl15866 205913005163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005164 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913005165 Walker A motif; other site 205913005166 ATP binding site [chemical binding]; other site 205913005167 Walker B motif; other site 205913005168 arginine finger; other site 205913005169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913005170 Integrase core domain; Region: rve; pfam00665 205913005171 transposase; Provisional; Region: PRK06526 205913005172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005173 Walker A motif; other site 205913005174 ATP binding site [chemical binding]; other site 205913005175 Walker B motif; other site 205913005176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913005177 Integrase core domain; Region: rve; pfam00665 205913005178 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 205913005179 substrate binding site [chemical binding]; other site 205913005180 active site 205913005181 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 205913005182 metal binding site [ion binding]; metal-binding site 205913005183 ligand binding site [chemical binding]; other site 205913005184 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 205913005185 active site 205913005186 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 205913005187 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 205913005188 16S/18S rRNA binding site [nucleotide binding]; other site 205913005189 S13e-L30e interaction site [polypeptide binding]; other site 205913005190 25S rRNA binding site [nucleotide binding]; other site 205913005191 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 205913005192 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 205913005193 oligomer interface [polypeptide binding]; other site 205913005194 RNA binding site [nucleotide binding]; other site 205913005195 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 205913005196 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 205913005197 RNase E interface [polypeptide binding]; other site 205913005198 trimer interface [polypeptide binding]; other site 205913005199 active site 205913005200 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 205913005201 putative nucleic acid binding region [nucleotide binding]; other site 205913005202 G-X-X-G motif; other site 205913005203 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 205913005204 RNA binding site [nucleotide binding]; other site 205913005205 domain interface; other site 205913005206 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 205913005207 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 205913005208 23S rRNA interface [nucleotide binding]; other site 205913005209 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 205913005210 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 205913005211 peripheral dimer interface [polypeptide binding]; other site 205913005212 core dimer interface [polypeptide binding]; other site 205913005213 L10 interface [polypeptide binding]; other site 205913005214 L11 interface [polypeptide binding]; other site 205913005215 putative EF-Tu interaction site [polypeptide binding]; other site 205913005216 putative EF-G interaction site [polypeptide binding]; other site 205913005217 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 205913005218 phosphopeptide binding site; other site 205913005219 Part of AAA domain; Region: AAA_19; pfam13245 205913005220 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 205913005221 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 205913005222 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 205913005223 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 205913005224 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 205913005225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 205913005226 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 205913005227 oligomerisation interface [polypeptide binding]; other site 205913005228 mobile loop; other site 205913005229 roof hairpin; other site 205913005230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913005231 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 205913005232 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 205913005233 FAD binding domain; Region: FAD_binding_4; pfam01565 205913005234 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 205913005235 amino acid transporter; Region: 2A0306; TIGR00909 205913005236 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 205913005237 Ferredoxin [Energy production and conversion]; Region: COG1146 205913005238 4Fe-4S binding domain; Region: Fer4; pfam00037 205913005239 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 205913005240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913005241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913005242 homodimer interface [polypeptide binding]; other site 205913005243 catalytic residue [active] 205913005244 DNA polymerase IV; Validated; Region: PRK03858 205913005245 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 205913005246 active site 205913005247 DNA binding site [nucleotide binding] 205913005248 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 205913005249 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 205913005250 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 205913005251 putative active site [active] 205913005252 putative metal binding site [ion binding]; other site 205913005253 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 205913005254 dimerization interface [polypeptide binding]; other site 205913005255 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 205913005256 NAD binding site [chemical binding]; other site 205913005257 ligand binding site [chemical binding]; other site 205913005258 catalytic site [active] 205913005259 Uncharacterized conserved protein [Function unknown]; Region: COG1739 205913005260 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 205913005261 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 205913005262 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 205913005263 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 205913005264 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 205913005265 23S rRNA interface [nucleotide binding]; other site 205913005266 L3 interface [polypeptide binding]; other site 205913005267 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 205913005268 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 205913005269 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 205913005270 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 205913005271 active site 205913005272 catalytic site [active] 205913005273 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 205913005274 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205913005275 putative NAD(P) binding site [chemical binding]; other site 205913005276 catalytic Zn binding site [ion binding]; other site 205913005277 polyol permease family; Region: 2A0118; TIGR00897 205913005278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005279 putative substrate translocation pore; other site 205913005280 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 205913005281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 205913005282 active site 205913005283 metal binding site [ion binding]; metal-binding site 205913005284 polyol permease family; Region: 2A0118; TIGR00897 205913005285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005286 putative substrate translocation pore; other site 205913005287 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 205913005288 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 205913005289 inhibitor binding site; inhibition site 205913005290 catalytic Zn binding site [ion binding]; other site 205913005291 structural Zn binding site [ion binding]; other site 205913005292 NADP binding site [chemical binding]; other site 205913005293 tetramer interface [polypeptide binding]; other site 205913005294 Helix-turn-helix domain; Region: HTH_18; pfam12833 205913005295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 205913005296 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205913005297 non-specific DNA interactions [nucleotide binding]; other site 205913005298 DNA binding site [nucleotide binding] 205913005299 sequence specific DNA binding site [nucleotide binding]; other site 205913005300 putative cAMP binding site [chemical binding]; other site 205913005301 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913005302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913005303 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 205913005304 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 205913005305 putative catalytic cysteine [active] 205913005306 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 205913005307 putative active site [active] 205913005308 metal binding site [ion binding]; metal-binding site 205913005309 YwiC-like protein; Region: YwiC; pfam14256 205913005310 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 205913005311 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 205913005312 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 205913005313 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 205913005314 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 205913005315 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 205913005316 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 205913005317 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 205913005318 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 205913005319 putative translocon binding site; other site 205913005320 protein-rRNA interface [nucleotide binding]; other site 205913005321 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 205913005322 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 205913005323 G-X-X-G motif; other site 205913005324 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 205913005325 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 205913005326 23S rRNA interface [nucleotide binding]; other site 205913005327 5S rRNA interface [nucleotide binding]; other site 205913005328 putative antibiotic binding site [chemical binding]; other site 205913005329 L25 interface [polypeptide binding]; other site 205913005330 L27 interface [polypeptide binding]; other site 205913005331 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 205913005332 23S rRNA interface [nucleotide binding]; other site 205913005333 putative translocon interaction site; other site 205913005334 signal recognition particle (SRP54) interaction site; other site 205913005335 L23 interface [polypeptide binding]; other site 205913005336 trigger factor interaction site; other site 205913005337 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 205913005338 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 205913005339 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 205913005340 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 205913005341 RNA binding site [nucleotide binding]; other site 205913005342 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 205913005343 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 205913005344 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 205913005345 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 205913005346 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 205913005347 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 205913005348 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205913005349 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 205913005350 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 205913005351 23S rRNA interface [nucleotide binding]; other site 205913005352 L21e interface [polypeptide binding]; other site 205913005353 5S rRNA interface [nucleotide binding]; other site 205913005354 L27 interface [polypeptide binding]; other site 205913005355 L5 interface [polypeptide binding]; other site 205913005356 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 205913005357 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 205913005358 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 205913005359 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 205913005360 23S rRNA binding site [nucleotide binding]; other site 205913005361 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 205913005362 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 205913005363 SecY translocase; Region: SecY; pfam00344 205913005364 adenylate kinase; Reviewed; Region: adk; PRK00279 205913005365 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 205913005366 AMP-binding site [chemical binding]; other site 205913005367 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 205913005368 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 205913005369 rRNA binding site [nucleotide binding]; other site 205913005370 predicted 30S ribosome binding site; other site 205913005371 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 205913005372 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 205913005373 30S ribosomal protein S13; Region: bact_S13; TIGR03631 205913005374 30S ribosomal protein S11; Validated; Region: PRK05309 205913005375 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 205913005376 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 205913005377 alphaNTD homodimer interface [polypeptide binding]; other site 205913005378 alphaNTD - beta interaction site [polypeptide binding]; other site 205913005379 alphaNTD - beta' interaction site [polypeptide binding]; other site 205913005380 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 205913005381 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 205913005382 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 205913005383 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 205913005384 dimerization interface 3.5A [polypeptide binding]; other site 205913005385 active site 205913005386 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 205913005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 205913005388 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 205913005389 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 205913005390 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 205913005391 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 205913005392 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 205913005393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913005394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913005395 DNA binding site [nucleotide binding] 205913005396 domain linker motif; other site 205913005397 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 205913005398 dimerization interface [polypeptide binding]; other site 205913005399 ligand binding site [chemical binding]; other site 205913005400 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 205913005401 NusA N-terminal domain; Region: NusA_N; pfam08529 205913005402 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 205913005403 RNA binding site [nucleotide binding]; other site 205913005404 homodimer interface [polypeptide binding]; other site 205913005405 NusA-like KH domain; Region: KH_5; pfam13184 205913005406 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 205913005407 G-X-X-G motif; other site 205913005408 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205913005409 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 205913005410 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 205913005411 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 205913005412 G1 box; other site 205913005413 putative GEF interaction site [polypeptide binding]; other site 205913005414 GTP/Mg2+ binding site [chemical binding]; other site 205913005415 Switch I region; other site 205913005416 G2 box; other site 205913005417 G3 box; other site 205913005418 Switch II region; other site 205913005419 G4 box; other site 205913005420 G5 box; other site 205913005421 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 205913005422 Translation-initiation factor 2; Region: IF-2; pfam11987 205913005423 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 205913005424 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 205913005425 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 205913005426 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 205913005427 RNA binding site [nucleotide binding]; other site 205913005428 active site 205913005429 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 205913005430 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 205913005431 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 205913005432 active site 205913005433 Riboflavin kinase; Region: Flavokinase; pfam01687 205913005434 DNA repair protein RadA; Provisional; Region: PRK11823 205913005435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 205913005436 Walker A motif; other site 205913005437 ATP binding site [chemical binding]; other site 205913005438 Walker B motif; other site 205913005439 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 205913005440 similar to hypothetical protein 205913005441 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 205913005442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913005443 active site 205913005444 dimer interface [polypeptide binding]; other site 205913005445 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 205913005446 RNA/DNA hybrid binding site [nucleotide binding]; other site 205913005447 active site 205913005448 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 205913005449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 205913005450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 205913005451 Transcriptional regulator; Region: Rrf2; pfam02082 205913005452 Rrf2 family protein; Region: rrf2_super; TIGR00738 205913005453 phosphoglucomutase; Validated; Region: PRK07564 205913005454 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 205913005455 active site 205913005456 substrate binding site [chemical binding]; other site 205913005457 metal binding site [ion binding]; metal-binding site 205913005458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005459 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 205913005460 putative substrate translocation pore; other site 205913005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005462 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 205913005463 active site turn [active] 205913005464 phosphorylation site [posttranslational modification] 205913005465 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 205913005466 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 205913005467 HPr interaction site; other site 205913005468 glycerol kinase (GK) interaction site [polypeptide binding]; other site 205913005469 active site 205913005470 phosphorylation site [posttranslational modification] 205913005471 transcriptional antiterminator BglG; Provisional; Region: PRK09772 205913005472 CAT RNA binding domain; Region: CAT_RBD; smart01061 205913005473 PRD domain; Region: PRD; pfam00874 205913005474 PRD domain; Region: PRD; pfam00874 205913005475 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 205913005476 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 205913005477 seryl-tRNA synthetase; Provisional; Region: PRK05431 205913005478 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 205913005479 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 205913005480 dimer interface [polypeptide binding]; other site 205913005481 active site 205913005482 motif 1; other site 205913005483 motif 2; other site 205913005484 motif 3; other site 205913005485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913005486 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913005487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913005488 dimer interface [polypeptide binding]; other site 205913005489 conserved gate region; other site 205913005490 ABC-ATPase subunit interface; other site 205913005491 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913005492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913005493 dimer interface [polypeptide binding]; other site 205913005494 conserved gate region; other site 205913005495 putative PBP binding loops; other site 205913005496 ABC-ATPase subunit interface; other site 205913005497 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 205913005498 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 205913005499 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 205913005500 Phosphotransferase enzyme family; Region: APH; pfam01636 205913005501 active site 205913005502 substrate binding site [chemical binding]; other site 205913005503 ATP binding site [chemical binding]; other site 205913005504 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 205913005505 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 205913005506 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 205913005507 UDP-glucose 4-epimerase; Region: PLN02240 205913005508 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 205913005509 NAD binding site [chemical binding]; other site 205913005510 homodimer interface [polypeptide binding]; other site 205913005511 active site 205913005512 substrate binding site [chemical binding]; other site 205913005513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 205913005514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 205913005515 active site 205913005516 phosphorylation site [posttranslational modification] 205913005517 intermolecular recognition site; other site 205913005518 dimerization interface [polypeptide binding]; other site 205913005519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 205913005520 DNA binding residues [nucleotide binding] 205913005521 dimerization interface [polypeptide binding]; other site 205913005522 PspC domain; Region: PspC; pfam04024 205913005523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 205913005524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913005525 ATP binding site [chemical binding]; other site 205913005526 Mg2+ binding site [ion binding]; other site 205913005527 G-X-G motif; other site 205913005528 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 205913005529 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 205913005530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 205913005531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 205913005532 binding surface 205913005533 TPR motif; other site 205913005534 Tetratricopeptide repeat; Region: TPR_12; pfam13424 205913005535 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 205913005536 MFS transport protein AraJ; Provisional; Region: PRK10091 205913005537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005538 putative substrate translocation pore; other site 205913005539 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 205913005540 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 205913005541 dimer interface [polypeptide binding]; other site 205913005542 putative anticodon binding site; other site 205913005543 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913005544 motif 1; other site 205913005545 dimer interface [polypeptide binding]; other site 205913005546 active site 205913005547 motif 2; other site 205913005548 motif 3; other site 205913005549 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 205913005550 UbiA prenyltransferase family; Region: UbiA; pfam01040 205913005551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 205913005552 catalytic core [active] 205913005553 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 205913005554 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 205913005555 PhoU domain; Region: PhoU; pfam01895 205913005556 PhoU domain; Region: PhoU; pfam01895 205913005557 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 205913005558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 205913005559 ATP binding site [chemical binding]; other site 205913005560 Mg2+ binding site [ion binding]; other site 205913005561 G-X-G motif; other site 205913005562 phosphoserine aminotransferase; Provisional; Region: PRK03080 205913005563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 205913005564 catalytic residue [active] 205913005565 CHAP domain; Region: CHAP; pfam05257 205913005566 NlpC/P60 family; Region: NLPC_P60; cl17555 205913005567 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 205913005568 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 205913005569 NlpC/P60 family; Region: NLPC_P60; pfam00877 205913005570 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913005571 Ligand Binding Site [chemical binding]; other site 205913005572 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 205913005573 Ligand Binding Site [chemical binding]; other site 205913005574 OsmC-like protein; Region: OsmC; pfam02566 205913005575 thymidylate synthase; Reviewed; Region: thyA; PRK01827 205913005576 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 205913005577 dimerization interface [polypeptide binding]; other site 205913005578 active site 205913005579 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 205913005580 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 205913005581 folate binding site [chemical binding]; other site 205913005582 NADP+ binding site [chemical binding]; other site 205913005583 Low molecular weight phosphatase family; Region: LMWPc; cd00115 205913005584 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 205913005585 active site 205913005586 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 205913005587 AzlC protein; Region: AzlC; cl00570 205913005588 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913005589 Int/Topo IB signature motif; other site 205913005590 DNA binding site [nucleotide binding] 205913005591 active site 205913005592 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913005593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005594 Walker A motif; other site 205913005595 ATP binding site [chemical binding]; other site 205913005596 Walker B motif; other site 205913005597 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 205913005598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913005599 DNA-binding interface [nucleotide binding]; DNA binding site 205913005600 Integrase core domain; Region: rve; pfam00665 205913005601 MULE transposase domain; Region: MULE; pfam10551 205913005602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005603 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 205913005604 Walker A motif; other site 205913005605 ATP binding site [chemical binding]; other site 205913005606 Walker B motif; other site 205913005607 arginine finger; other site 205913005608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 205913005609 Integrase core domain; Region: rve; pfam00665 205913005610 Integrase core domain; Region: rve_2; pfam13333 205913005611 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 205913005612 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913005613 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 205913005614 Int/Topo IB signature motif; other site 205913005615 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 205913005616 Int/Topo IB signature motif; other site 205913005617 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 205913005618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 205913005619 active site 205913005620 DNA binding site [nucleotide binding] 205913005621 Int/Topo IB signature motif; other site 205913005622 Transposase; Region: HTH_Tnp_1; cl17663 205913005623 HTH-like domain; Region: HTH_21; pfam13276 205913005624 Integrase core domain; Region: rve; pfam00665 205913005625 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 205913005626 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 205913005627 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 205913005628 N-acetyl-D-glucosamine binding site [chemical binding]; other site 205913005629 catalytic residue [active] 205913005630 Surface antigen [General function prediction only]; Region: COG3942 205913005631 CHAP domain; Region: CHAP; pfam05257 205913005632 AAA-like domain; Region: AAA_10; pfam12846 205913005633 AAA-like domain; Region: AAA_10; pfam12846 205913005634 Domain of unknown function DUF87; Region: DUF87; pfam01935 205913005635 PrgI family protein; Region: PrgI; pfam12666 205913005636 Transposase, Mutator family; Region: Transposase_mut; pfam00872 205913005637 MULE transposase domain; Region: MULE; pfam10551 205913005638 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 205913005639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913005640 Walker A/P-loop; other site 205913005641 ATP binding site [chemical binding]; other site 205913005642 AAA domain; Region: AAA_21; pfam13304 205913005643 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 205913005644 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 205913005645 P-loop; other site 205913005646 Magnesium ion binding site [ion binding]; other site 205913005647 hypothetical protein; Region: PHA01623 205913005648 Transcription factor WhiB; Region: Whib; pfam02467 205913005649 Helix-turn-helix domain; Region: HTH_36; pfam13730 205913005650 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 205913005651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 205913005652 sequence-specific DNA binding site [nucleotide binding]; other site 205913005653 salt bridge; other site 205913005654 Putative methyltransferase; Region: Methyltransf_4; cl17290 205913005655 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 205913005656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 205913005657 NAD(P) binding site [chemical binding]; other site 205913005658 active site 205913005659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913005661 putative substrate translocation pore; other site 205913005662 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 205913005663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913005664 S-adenosylmethionine binding site [chemical binding]; other site 205913005665 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 205913005666 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 205913005667 dimer interface [polypeptide binding]; other site 205913005668 active site 205913005669 metal binding site [ion binding]; metal-binding site 205913005670 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 205913005671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 205913005672 active site 205913005673 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 205913005674 Domain of unknown function DUF20; Region: UPF0118; pfam01594 205913005675 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 205913005676 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 205913005677 DXD motif; other site 205913005678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 205913005679 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 205913005680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 205913005681 Walker A/P-loop; other site 205913005682 ATP binding site [chemical binding]; other site 205913005683 Q-loop/lid; other site 205913005684 ABC transporter signature motif; other site 205913005685 Walker B; other site 205913005686 D-loop; other site 205913005687 H-loop/switch region; other site 205913005688 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 205913005689 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 205913005690 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 205913005691 Ligand Binding Site [chemical binding]; other site 205913005692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 205913005693 active site 205913005694 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 205913005695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005696 Walker A motif; other site 205913005697 ATP binding site [chemical binding]; other site 205913005698 Walker B motif; other site 205913005699 arginine finger; other site 205913005700 Peptidase family M41; Region: Peptidase_M41; pfam01434 205913005701 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 205913005702 GTP cyclohydrolase I; Provisional; Region: PLN03044 205913005703 active site 205913005704 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 205913005705 dihydropteroate synthase; Region: DHPS; TIGR01496 205913005706 substrate binding pocket [chemical binding]; other site 205913005707 dimer interface [polypeptide binding]; other site 205913005708 inhibitor binding site; inhibition site 205913005709 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 205913005710 homooctamer interface [polypeptide binding]; other site 205913005711 active site 205913005712 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 205913005713 catalytic center binding site [active] 205913005714 ATP binding site [chemical binding]; other site 205913005715 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 205913005716 catalytic center binding site [active] 205913005717 ATP binding site [chemical binding]; other site 205913005718 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 205913005719 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 205913005720 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 205913005721 active site 205913005722 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 205913005723 catalytic triad [active] 205913005724 dimer interface [polypeptide binding]; other site 205913005725 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 205913005726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913005727 Walker A/P-loop; other site 205913005728 ATP binding site [chemical binding]; other site 205913005729 Q-loop/lid; other site 205913005730 ABC transporter signature motif; other site 205913005731 Walker B; other site 205913005732 D-loop; other site 205913005733 H-loop/switch region; other site 205913005734 ABC transporter; Region: ABC_tran_2; pfam12848 205913005735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 205913005736 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 205913005737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205913005738 nucleotide binding site [chemical binding]; other site 205913005739 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 205913005740 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205913005741 Walker A/P-loop; other site 205913005742 ATP binding site [chemical binding]; other site 205913005743 Q-loop/lid; other site 205913005744 ABC transporter signature motif; other site 205913005745 Walker B; other site 205913005746 D-loop; other site 205913005747 H-loop/switch region; other site 205913005748 MarR family; Region: MarR_2; pfam12802 205913005749 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913005750 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205913005751 nucleotide binding site [chemical binding]; other site 205913005752 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913005753 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 205913005754 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 205913005755 putative ligand binding site [chemical binding]; other site 205913005756 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 205913005757 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 205913005758 Walker A/P-loop; other site 205913005759 ATP binding site [chemical binding]; other site 205913005760 Q-loop/lid; other site 205913005761 ABC transporter signature motif; other site 205913005762 Walker B; other site 205913005763 D-loop; other site 205913005764 H-loop/switch region; other site 205913005765 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 205913005766 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913005767 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 205913005768 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205913005769 TM-ABC transporter signature motif; other site 205913005770 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 205913005771 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 205913005772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913005773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 205913005774 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 205913005775 active site 205913005776 catalytic tetrad [active] 205913005777 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 205913005778 active site 205913005779 catalytic residues [active] 205913005780 metal binding site [ion binding]; metal-binding site 205913005781 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913005782 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 205913005783 xylose isomerase; Provisional; Region: PRK05474 205913005784 xylose isomerase; Region: xylose_isom_A; TIGR02630 205913005785 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 205913005786 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 205913005787 dimer interface [polypeptide binding]; other site 205913005788 active site 205913005789 metal binding site [ion binding]; metal-binding site 205913005790 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913005791 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913005792 DNA binding site [nucleotide binding] 205913005793 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 205913005794 putative dimerization interface [polypeptide binding]; other site 205913005795 putative ligand binding site [chemical binding]; other site 205913005796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 205913005797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 205913005798 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 205913005799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913005800 dimer interface [polypeptide binding]; other site 205913005801 conserved gate region; other site 205913005802 putative PBP binding loops; other site 205913005803 ABC-ATPase subunit interface; other site 205913005804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913005805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 205913005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 205913005807 dimer interface [polypeptide binding]; other site 205913005808 conserved gate region; other site 205913005809 putative PBP binding loops; other site 205913005810 ABC-ATPase subunit interface; other site 205913005811 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 205913005812 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 205913005813 inhibitor binding site; inhibition site 205913005814 active site 205913005815 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 205913005816 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 205913005817 active site 205913005818 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 205913005819 trimer interface [polypeptide binding]; other site 205913005820 active site 205913005821 substrate binding site [chemical binding]; other site 205913005822 CoA binding site [chemical binding]; other site 205913005823 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 205913005824 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 205913005825 N- and C-terminal domain interface [polypeptide binding]; other site 205913005826 D-xylulose kinase; Region: XylB; TIGR01312 205913005827 active site 205913005828 MgATP binding site [chemical binding]; other site 205913005829 catalytic site [active] 205913005830 metal binding site [ion binding]; metal-binding site 205913005831 xylulose binding site [chemical binding]; other site 205913005832 putative homodimer interface [polypeptide binding]; other site 205913005833 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 205913005834 non-specific DNA interactions [nucleotide binding]; other site 205913005835 DNA binding site [nucleotide binding] 205913005836 sequence specific DNA binding site [nucleotide binding]; other site 205913005837 putative cAMP binding site [chemical binding]; other site 205913005838 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 205913005839 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 205913005840 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 205913005841 peptide chain release factor 1; Validated; Region: prfA; PRK00591 205913005842 This domain is found in peptide chain release factors; Region: PCRF; smart00937 205913005843 RF-1 domain; Region: RF-1; pfam00472 205913005844 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 205913005845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 205913005846 S-adenosylmethionine binding site [chemical binding]; other site 205913005847 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 205913005848 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 205913005849 putative ligand binding site [chemical binding]; other site 205913005850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 205913005851 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 205913005852 TM-ABC transporter signature motif; other site 205913005853 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 205913005854 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 205913005855 TM-ABC transporter signature motif; other site 205913005856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 205913005857 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 205913005858 Walker A/P-loop; other site 205913005859 ATP binding site [chemical binding]; other site 205913005860 Q-loop/lid; other site 205913005861 ABC transporter signature motif; other site 205913005862 Walker B; other site 205913005863 D-loop; other site 205913005864 H-loop/switch region; other site 205913005865 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 205913005866 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 205913005867 Walker A/P-loop; other site 205913005868 ATP binding site [chemical binding]; other site 205913005869 Q-loop/lid; other site 205913005870 ABC transporter signature motif; other site 205913005871 Walker B; other site 205913005872 D-loop; other site 205913005873 H-loop/switch region; other site 205913005874 maltose O-acetyltransferase; Provisional; Region: PRK10092 205913005875 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 205913005876 active site 205913005877 substrate binding site [chemical binding]; other site 205913005878 trimer interface [polypeptide binding]; other site 205913005879 CoA binding site [chemical binding]; other site 205913005880 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 205913005881 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 205913005882 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 205913005883 Mg++ binding site [ion binding]; other site 205913005884 putative catalytic motif [active] 205913005885 substrate binding site [chemical binding]; other site 205913005886 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 205913005887 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 205913005888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 205913005889 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 205913005890 active site 205913005891 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 205913005892 catalytic site [active] 205913005893 putative active site [active] 205913005894 putative substrate binding site [chemical binding]; other site 205913005895 dimer interface [polypeptide binding]; other site 205913005896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913005897 PIF1-like helicase; Region: PIF1; pfam05970 205913005898 Walker A motif; other site 205913005899 ATP binding site [chemical binding]; other site 205913005900 Walker B motif; other site 205913005901 arginine finger; other site 205913005902 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 205913005903 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 205913005904 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 205913005905 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 205913005906 prolyl-tRNA synthetase; Provisional; Region: PRK09194 205913005907 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 205913005908 dimer interface [polypeptide binding]; other site 205913005909 motif 1; other site 205913005910 active site 205913005911 motif 2; other site 205913005912 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 205913005913 putative deacylase active site [active] 205913005914 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 205913005915 active site 205913005916 motif 3; other site 205913005917 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 205913005918 anticodon binding site; other site 205913005919 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 205913005920 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 205913005921 tetramer (dimer of dimers) interface [polypeptide binding]; other site 205913005922 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 205913005923 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 205913005924 active site 205913005925 Zn binding site [ion binding]; other site 205913005926 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 205913005927 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 205913005928 active site 205913005929 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 205913005930 Citrate synthase; Region: Citrate_synt; pfam00285 205913005931 oxalacetate binding site [chemical binding]; other site 205913005932 citrylCoA binding site [chemical binding]; other site 205913005933 coenzyme A binding site [chemical binding]; other site 205913005934 catalytic triad [active] 205913005935 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 205913005936 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 205913005937 putative trimer interface [polypeptide binding]; other site 205913005938 putative CoA binding site [chemical binding]; other site 205913005939 Penicillinase repressor; Region: Pencillinase_R; cl17580 205913005940 WYL domain; Region: WYL; pfam13280 205913005941 SWIM zinc finger; Region: SWIM; pfam04434 205913005942 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 205913005943 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 205913005944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913005945 ATP binding site [chemical binding]; other site 205913005946 putative Mg++ binding site [ion binding]; other site 205913005947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 205913005948 nucleotide binding region [chemical binding]; other site 205913005949 ATP-binding site [chemical binding]; other site 205913005950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 205913005951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913005952 Coenzyme A binding pocket [chemical binding]; other site 205913005953 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 205913005954 additional DNA contacts [nucleotide binding]; other site 205913005955 mismatch recognition site; other site 205913005956 active site 205913005957 zinc binding site [ion binding]; other site 205913005958 DNA intercalation site [nucleotide binding]; other site 205913005959 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 205913005960 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 205913005961 hypothetical protein; Provisional; Region: PRK08960 205913005962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913005963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913005964 homodimer interface [polypeptide binding]; other site 205913005965 catalytic residue [active] 205913005966 exopolyphosphatase; Region: exo_poly_only; TIGR03706 205913005967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 205913005968 nucleotide binding site [chemical binding]; other site 205913005969 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 205913005970 putative catalytic site [active] 205913005971 putative metal binding site [ion binding]; other site 205913005972 putative phosphate binding site [ion binding]; other site 205913005973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 205913005974 Coenzyme A binding pocket [chemical binding]; other site 205913005975 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 205913005976 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 205913005977 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 205913005978 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 205913005979 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 205913005980 acyl-activating enzyme (AAE) consensus motif; other site 205913005981 putative AMP binding site [chemical binding]; other site 205913005982 putative active site [active] 205913005983 putative CoA binding site [chemical binding]; other site 205913005984 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 205913005985 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 205913005986 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 205913005987 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 205913005988 generic binding surface II; other site 205913005989 generic binding surface I; other site 205913005990 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 205913005991 ATP cone domain; Region: ATP-cone; pfam03477 205913005992 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 205913005993 Class III ribonucleotide reductase; Region: RNR_III; cd01675 205913005994 active site 205913005995 Zn binding site [ion binding]; other site 205913005996 glycine loop; other site 205913005997 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 205913005998 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 205913005999 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 205913006000 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 205913006001 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 205913006002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 205913006003 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 205913006004 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 205913006005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 205913006006 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 205913006007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913006008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913006009 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 205913006010 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 205913006011 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 205913006012 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 205913006013 active site 205913006014 NTP binding site [chemical binding]; other site 205913006015 metal binding triad [ion binding]; metal-binding site 205913006016 antibiotic binding site [chemical binding]; other site 205913006017 nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987 205913006018 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 205913006019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913006020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913006021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 205913006022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 205913006023 putative substrate translocation pore; other site 205913006024 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 205913006025 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 205913006026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 205913006027 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 205913006028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 205913006029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 205913006030 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 205913006031 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 205913006032 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 205913006033 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 205913006034 Transcriptional regulators [Transcription]; Region: MarR; COG1846 205913006035 MarR family; Region: MarR_2; pfam12802 205913006036 MarR family; Region: MarR_2; cl17246 205913006037 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 205913006038 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913006039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 205913006040 Walker A/P-loop; other site 205913006041 ATP binding site [chemical binding]; other site 205913006042 Q-loop/lid; other site 205913006043 ABC transporter signature motif; other site 205913006044 Walker B; other site 205913006045 D-loop; other site 205913006046 H-loop/switch region; other site 205913006047 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 205913006048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 205913006049 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 205913006050 Walker A/P-loop; other site 205913006051 ATP binding site [chemical binding]; other site 205913006052 Q-loop/lid; other site 205913006053 ABC transporter signature motif; other site 205913006054 Walker B; other site 205913006055 D-loop; other site 205913006056 H-loop/switch region; other site 205913006057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 205913006058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 205913006059 DNA binding site [nucleotide binding] 205913006060 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 205913006061 putative dimerization interface [polypeptide binding]; other site 205913006062 putative ligand binding site [chemical binding]; other site 205913006063 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 205913006064 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 205913006065 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 205913006066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 205913006067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 205913006068 homodimer interface [polypeptide binding]; other site 205913006069 catalytic residue [active] 205913006070 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 205913006071 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205913006072 HIGH motif; other site 205913006073 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 205913006074 active site 205913006075 KMSKS motif; other site 205913006076 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 205913006077 tRNA binding surface [nucleotide binding]; other site 205913006078 anticodon binding site; other site 205913006079 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913006080 Transposase, Mutator family; Region: Transposase_mut; pfam00872 205913006081 MULE transposase domain; Region: MULE; pfam10551 205913006082 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 205913006083 Int/Topo IB signature motif; other site 205913006084 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913006085 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 205913006086 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 205913006087 Mrr N-terminal domain; Region: Mrr_N; pfam14338 205913006088 Restriction endonuclease; Region: Mrr_cat; pfam04471 205913006089 HsdM N-terminal domain; Region: HsdM_N; pfam12161 205913006090 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 205913006091 Methyltransferase domain; Region: Methyltransf_26; pfam13659 205913006092 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913006093 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 205913006094 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 205913006095 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 205913006096 Divergent AAA domain; Region: AAA_4; pfam04326 205913006097 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 205913006098 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 205913006099 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 205913006100 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 205913006101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 205913006102 ATP binding site [chemical binding]; other site 205913006103 putative Mg++ binding site [ion binding]; other site 205913006104 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 205913006105 S-adenosylmethionine synthetase; Validated; Region: PRK05250 205913006106 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 205913006107 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 205913006108 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 205913006109 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 205913006110 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 205913006111 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 205913006112 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 205913006113 putative active site [active] 205913006114 substrate binding site [chemical binding]; other site 205913006115 putative cosubstrate binding site; other site 205913006116 catalytic site [active] 205913006117 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 205913006118 substrate binding site [chemical binding]; other site 205913006119 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 205913006120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913006121 primosome assembly protein PriA; Provisional; Region: PRK14873 205913006122 phosphoserine phosphatase SerB; Region: serB; TIGR00338 205913006123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 205913006124 motif II; other site 205913006125 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 205913006126 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 205913006127 proteasome ATPase; Region: pup_AAA; TIGR03689 205913006128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 205913006129 Walker A motif; other site 205913006130 ATP binding site [chemical binding]; other site 205913006131 Walker B motif; other site 205913006132 arginine finger; other site 205913006133 Pup-ligase protein; Region: Pup_ligase; cl15463 205913006134 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 205913006135 active site 205913006136 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 205913006137 Pup-like protein; Region: Pup; cl05289 205913006138 Pup-ligase protein; Region: Pup_ligase; cl15463 205913006139 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 205913006140 IHF dimer interface [polypeptide binding]; other site 205913006141 IHF - DNA interface [nucleotide binding]; other site 205913006142 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 205913006143 adenylosuccinate lyase; Provisional; Region: PRK09285 205913006144 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 205913006145 tetramer interface [polypeptide binding]; other site 205913006146 active site 205913006147 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 205913006148 PGAP1-like protein; Region: PGAP1; pfam07819 205913006149 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 205913006150 metal ion-dependent adhesion site (MIDAS); other site 205913006151 von Willebrand factor type A domain; Region: VWA_2; pfam13519 205913006152 Protein of unknown function DUF58; Region: DUF58; pfam01882 205913006153 MoxR-like ATPases [General function prediction only]; Region: COG0714 205913006154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 205913006155 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 205913006156 ligand binding site [chemical binding]; other site 205913006157 active site 205913006158 UGI interface [polypeptide binding]; other site 205913006159 catalytic site [active] 205913006160 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399