-- dump date   	20140619_002431
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
866777000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
866777000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777000003	Walker A motif; other site
866777000004	ATP binding site [chemical binding]; other site
866777000005	Walker B motif; other site
866777000006	arginine finger; other site
866777000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
866777000008	DnaA box-binding interface [nucleotide binding]; other site
866777000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
866777000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
866777000011	putative DNA binding surface [nucleotide binding]; other site
866777000012	dimer interface [polypeptide binding]; other site
866777000013	beta-clamp/clamp loader binding surface; other site
866777000014	beta-clamp/translesion DNA polymerase binding surface; other site
866777000015	recombination protein F; Reviewed; Region: recF; PRK00064
866777000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777000017	Walker A/P-loop; other site
866777000018	ATP binding site [chemical binding]; other site
866777000019	Q-loop/lid; other site
866777000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777000021	ABC transporter signature motif; other site
866777000022	Walker B; other site
866777000023	D-loop; other site
866777000024	H-loop/switch region; other site
866777000025	Protein of unknown function (DUF721); Region: DUF721; pfam05258
866777000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
866777000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777000028	Mg2+ binding site [ion binding]; other site
866777000029	G-X-G motif; other site
866777000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866777000031	anchoring element; other site
866777000032	dimer interface [polypeptide binding]; other site
866777000033	ATP binding site [chemical binding]; other site
866777000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866777000035	active site
866777000036	putative metal-binding site [ion binding]; other site
866777000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866777000038	DNA gyrase subunit A; Validated; Region: PRK05560
866777000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866777000040	CAP-like domain; other site
866777000041	active site
866777000042	primary dimer interface [polypeptide binding]; other site
866777000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
866777000050	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000051	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777000052	DNA binding site [nucleotide binding]
866777000053	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777000054	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
866777000055	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
866777000056	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
866777000057	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
866777000058	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
866777000059	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
866777000060	VanZ like family; Region: VanZ; cl01971
866777000061	glutamate dehydrogenase; Provisional; Region: PRK09414
866777000062	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866777000063	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
866777000064	NAD(P) binding site [chemical binding]; other site
866777000065	Protein of unknown function DUF45; Region: DUF45; pfam01863
866777000066	AAA domain; Region: AAA_14; pfam13173
866777000067	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
866777000068	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
866777000069	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
866777000070	dimerization interface [polypeptide binding]; other site
866777000071	DPS ferroxidase diiron center [ion binding]; other site
866777000072	ion pore; other site
866777000073	Domain of unknown function DUF21; Region: DUF21; pfam01595
866777000074	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866777000075	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866777000076	Transporter associated domain; Region: CorC_HlyC; smart01091
866777000077	AAA ATPase domain; Region: AAA_16; pfam13191
866777000078	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
866777000079	active site clefts [active]
866777000080	zinc binding site [ion binding]; other site
866777000081	dimer interface [polypeptide binding]; other site
866777000082	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
866777000083	peroxiredoxin; Region: AhpC; TIGR03137
866777000084	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
866777000085	dimer interface [polypeptide binding]; other site
866777000086	decamer (pentamer of dimers) interface [polypeptide binding]; other site
866777000087	catalytic triad [active]
866777000088	peroxidatic and resolving cysteines [active]
866777000089	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
866777000090	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866777000091	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866777000092	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
866777000093	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
866777000094	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866777000095	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866777000096	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
866777000097	GAF domain; Region: GAF_3; pfam13492
866777000098	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
866777000099	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
866777000100	NodB motif; other site
866777000101	putative active site [active]
866777000102	putative catalytic site [active]
866777000103	putative Zn binding site [ion binding]; other site
866777000104	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
866777000105	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866777000106	Predicted membrane protein [Function unknown]; Region: COG4267
866777000107	CotH protein; Region: CotH; pfam08757
866777000108	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
866777000109	putative metal binding residues [ion binding]; other site
866777000110	signature motif; other site
866777000111	dimer interface [polypeptide binding]; other site
866777000112	active site
866777000113	polyP binding site; other site
866777000114	substrate binding site [chemical binding]; other site
866777000115	acceptor-phosphate pocket; other site
866777000116	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866777000117	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866777000118	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866777000119	metal binding site [ion binding]; metal-binding site
866777000120	active site
866777000121	I-site; other site
866777000122	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
866777000123	AAA domain; Region: AAA_14; pfam13173
866777000124	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
866777000125	Divergent AAA domain; Region: AAA_4; pfam04326
866777000126	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
866777000127	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
866777000128	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
866777000129	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777000130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000131	dimer interface [polypeptide binding]; other site
866777000132	conserved gate region; other site
866777000133	putative PBP binding loops; other site
866777000134	ABC-ATPase subunit interface; other site
866777000135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000136	dimer interface [polypeptide binding]; other site
866777000137	conserved gate region; other site
866777000138	putative PBP binding loops; other site
866777000139	ABC-ATPase subunit interface; other site
866777000140	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777000141	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866777000142	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
866777000143	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866777000144	active site
866777000145	metal binding site [ion binding]; metal-binding site
866777000146	hexamer interface [polypeptide binding]; other site
866777000147	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
866777000148	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777000149	Q-loop/lid; other site
866777000150	ABC transporter signature motif; other site
866777000151	Walker B; other site
866777000152	D-loop; other site
866777000153	H-loop/switch region; other site
866777000154	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866777000155	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
866777000156	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
866777000157	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
866777000158	Na binding site [ion binding]; other site
866777000159	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
866777000160	Amidohydrolase family; Region: Amidohydro_3; pfam07969
866777000161	active site
866777000162	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
866777000163	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
866777000164	active site
866777000165	HIGH motif; other site
866777000166	dimer interface [polypeptide binding]; other site
866777000167	KMSKS motif; other site
866777000168	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777000169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777000170	active site
866777000171	phosphorylation site [posttranslational modification]
866777000172	intermolecular recognition site; other site
866777000173	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777000174	DNA binding residues [nucleotide binding]
866777000175	dimerization interface [polypeptide binding]; other site
866777000176	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866777000177	H+ Antiporter protein; Region: 2A0121; TIGR00900
866777000178	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
866777000179	homodimer interface [polypeptide binding]; other site
866777000180	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
866777000181	active site pocket [active]
866777000182	Rhomboid family; Region: Rhomboid; pfam01694
866777000183	putative septation inhibitor protein; Reviewed; Region: PRK02251
866777000184	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
866777000185	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
866777000186	active site
866777000187	catalytic site [active]
866777000188	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
866777000189	Glutamine amidotransferase class-I; Region: GATase; pfam00117
866777000190	glutamine binding [chemical binding]; other site
866777000191	catalytic triad [active]
866777000192	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
866777000193	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
866777000194	active site
866777000195	ATP binding site [chemical binding]; other site
866777000196	substrate binding site [chemical binding]; other site
866777000197	activation loop (A-loop); other site
866777000198	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866777000199	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866777000200	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866777000201	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866777000202	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
866777000203	Catalytic domain of Protein Kinases; Region: PKc; cd00180
866777000204	active site
866777000205	ATP binding site [chemical binding]; other site
866777000206	substrate binding site [chemical binding]; other site
866777000207	activation loop (A-loop); other site
866777000208	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866777000209	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
866777000210	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
866777000211	active site
866777000212	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
866777000213	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
866777000214	phosphopeptide binding site; other site
866777000215	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
866777000216	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
866777000217	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
866777000218	phosphopeptide binding site; other site
866777000219	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
866777000220	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866777000221	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866777000222	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
866777000223	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866777000224	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
866777000225	putative dimer interface [polypeptide binding]; other site
866777000226	aromatic amino acid exporter; Provisional; Region: PRK11689
866777000227	Putative esterase; Region: Esterase; pfam00756
866777000228	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
866777000229	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
866777000230	methionine sulfoxide reductase B; Provisional; Region: PRK00222
866777000231	SelR domain; Region: SelR; pfam01641
866777000232	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
866777000233	Fic family protein [Function unknown]; Region: COG3177
866777000234	Fic/DOC family; Region: Fic; pfam02661
866777000235	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
866777000236	putative DNA binding helix; other site
866777000237	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866777000238	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866777000239	active site
866777000240	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
866777000241	PLD-like domain; Region: PLDc_2; pfam13091
866777000242	putative homodimer interface [polypeptide binding]; other site
866777000243	putative active site [active]
866777000244	catalytic site [active]
866777000245	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866777000246	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777000247	ATP binding site [chemical binding]; other site
866777000248	putative Mg++ binding site [ion binding]; other site
866777000249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777000250	nucleotide binding region [chemical binding]; other site
866777000251	ATP-binding site [chemical binding]; other site
866777000252	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
866777000253	hypothetical protein; Provisional; Region: PRK01119
866777000254	Haemolysin-III related; Region: HlyIII; pfam03006
866777000255	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
866777000256	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
866777000257	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
866777000258	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866777000259	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866777000260	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866777000261	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866777000262	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
866777000263	ferredoxin-NADP+ reductase; Region: PLN02852
866777000264	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866777000265	heat shock protein HtpX; Provisional; Region: PRK03072
866777000266	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866777000267	EamA-like transporter family; Region: EamA; pfam00892
866777000268	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
866777000269	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
866777000270	active site
866777000271	intersubunit interface [polypeptide binding]; other site
866777000272	zinc binding site [ion binding]; other site
866777000273	Na+ binding site [ion binding]; other site
866777000274	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
866777000275	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
866777000276	GDP-binding site [chemical binding]; other site
866777000277	ACT binding site; other site
866777000278	IMP binding site; other site
866777000279	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
866777000280	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
866777000281	Cl- selectivity filter; other site
866777000282	Cl- binding residues [ion binding]; other site
866777000283	pore gating glutamate residue; other site
866777000284	dimer interface [polypeptide binding]; other site
866777000285	H+/Cl- coupling transport residue; other site
866777000286	TrkA-C domain; Region: TrkA_C; pfam02080
866777000287	CrcB-like protein; Region: CRCB; pfam02537
866777000288	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000289	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777000290	DNA binding site [nucleotide binding]
866777000291	domain linker motif; other site
866777000292	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777000293	sucrose phosphorylase; Provisional; Region: PRK13840
866777000294	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
866777000295	active site
866777000296	homodimer interface [polypeptide binding]; other site
866777000297	catalytic site [active]
866777000298	Domain of unknown function (DUF1964); Region: DUF1964; pfam09244
866777000299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777000300	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000301	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777000302	DNA binding site [nucleotide binding]
866777000303	domain linker motif; other site
866777000304	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
866777000305	dimerization interface [polypeptide binding]; other site
866777000306	ligand binding site [chemical binding]; other site
866777000307	sodium binding site [ion binding]; other site
866777000308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777000309	metabolite-proton symporter; Region: 2A0106; TIGR00883
866777000310	putative substrate translocation pore; other site
866777000311	ketol-acid reductoisomerase; Provisional; Region: PRK05479
866777000312	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
866777000313	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
866777000314	ketol-acid reductoisomerase; Provisional; Region: PRK05479
866777000315	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
866777000316	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
866777000317	MarR family; Region: MarR_2; cl17246
866777000318	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
866777000319	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866777000320	active site
866777000321	catalytic site [active]
866777000322	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000323	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777000324	DNA binding site [nucleotide binding]
866777000325	domain linker motif; other site
866777000326	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777000327	ligand binding site [chemical binding]; other site
866777000328	dimerization interface [polypeptide binding]; other site
866777000329	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
866777000330	Cna protein B-type domain; Region: Cna_B; pfam05738
866777000331	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
866777000332	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
866777000333	active site
866777000334	catalytic site [active]
866777000335	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
866777000336	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
866777000337	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866777000338	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348
866777000339	active site
866777000340	catalytic site [active]
866777000341	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
866777000342	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777000343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000344	dimer interface [polypeptide binding]; other site
866777000345	conserved gate region; other site
866777000346	putative PBP binding loops; other site
866777000347	ABC-ATPase subunit interface; other site
866777000348	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777000349	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866777000350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000351	dimer interface [polypeptide binding]; other site
866777000352	conserved gate region; other site
866777000353	ABC-ATPase subunit interface; other site
866777000354	TraX protein; Region: TraX; cl05434
866777000355	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000356	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777000357	DNA binding site [nucleotide binding]
866777000358	domain linker motif; other site
866777000359	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777000360	ligand binding site [chemical binding]; other site
866777000361	dimerization interface [polypeptide binding]; other site
866777000362	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
866777000363	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866777000364	active site
866777000365	Ca binding site [ion binding]; other site
866777000366	catalytic site [active]
866777000367	Aamy_C domain; Region: Aamy_C; smart00632
866777000368	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
866777000369	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
866777000370	carbohydrate binding site [chemical binding]; other site
866777000371	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
866777000372	carbohydrate binding site [chemical binding]; other site
866777000373	pullulanase, type I; Region: pulA_typeI; TIGR02104
866777000374	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
866777000375	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
866777000376	Ca binding site [ion binding]; other site
866777000377	active site
866777000378	catalytic site [active]
866777000379	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
866777000380	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777000381	nucleotide binding site [chemical binding]; other site
866777000382	GrpE; Region: GrpE; pfam01025
866777000383	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
866777000384	dimer interface [polypeptide binding]; other site
866777000385	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
866777000386	chaperone protein DnaJ; Provisional; Region: PRK14299
866777000387	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866777000388	HSP70 interaction site [polypeptide binding]; other site
866777000389	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
866777000390	substrate binding site [polypeptide binding]; other site
866777000391	dimer interface [polypeptide binding]; other site
866777000392	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
866777000393	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866777000394	DNA binding residues [nucleotide binding]
866777000395	putative dimer interface [polypeptide binding]; other site
866777000396	xanthine permease; Region: pbuX; TIGR03173
866777000397	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
866777000398	catalytic residues [active]
866777000399	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
866777000400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866777000401	NAD(P) binding site [chemical binding]; other site
866777000402	active site
866777000403	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
866777000404	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777000405	motif II; other site
866777000406	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
866777000407	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866777000408	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
866777000409	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866777000410	Type II/IV secretion system protein; Region: T2SE; pfam00437
866777000411	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
866777000412	ATP binding site [chemical binding]; other site
866777000413	Walker A motif; other site
866777000414	hexamer interface [polypeptide binding]; other site
866777000415	Walker B motif; other site
866777000416	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
866777000417	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
866777000418	TadE-like protein; Region: TadE; pfam07811
866777000419	diacylglycerol kinase; Reviewed; Region: PRK11914
866777000420	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866777000421	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777000422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777000423	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
866777000424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777000425	Walker A motif; other site
866777000426	ATP binding site [chemical binding]; other site
866777000427	Walker B motif; other site
866777000428	arginine finger; other site
866777000429	recombination protein RecR; Reviewed; Region: recR; PRK00076
866777000430	RecR protein; Region: RecR; pfam02132
866777000431	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
866777000432	putative active site [active]
866777000433	putative metal-binding site [ion binding]; other site
866777000434	tetramer interface [polypeptide binding]; other site
866777000435	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866777000436	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866777000437	sequence-specific DNA binding site [nucleotide binding]; other site
866777000438	salt bridge; other site
866777000439	Replication initiation factor; Region: Rep_trans; pfam02486
866777000440	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
866777000441	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
866777000442	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
866777000443	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
866777000444	Int/Topo IB signature motif; other site
866777000445	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
866777000446	active site
866777000447	catalytic site [active]
866777000448	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
866777000449	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
866777000450	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
866777000451	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866777000452	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866777000453	transposase/IS protein; Provisional; Region: PRK09183
866777000454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777000455	Walker A motif; other site
866777000456	ATP binding site [chemical binding]; other site
866777000457	Walker B motif; other site
866777000458	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
866777000459	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866777000460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866777000461	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
866777000462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000463	dimer interface [polypeptide binding]; other site
866777000464	conserved gate region; other site
866777000465	putative PBP binding loops; other site
866777000466	ABC-ATPase subunit interface; other site
866777000467	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
866777000468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777000469	Walker A/P-loop; other site
866777000470	ATP binding site [chemical binding]; other site
866777000471	Q-loop/lid; other site
866777000472	ABC transporter signature motif; other site
866777000473	Walker B; other site
866777000474	D-loop; other site
866777000475	H-loop/switch region; other site
866777000476	Uncharacterized conserved protein [Function unknown]; Region: COG3379
866777000477	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
866777000478	Helix-turn-helix domain; Region: HTH_38; pfam13936
866777000479	DNA-binding interface [nucleotide binding]; DNA binding site
866777000480	Integrase core domain; Region: rve; pfam00665
866777000481	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
866777000482	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777000483	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
866777000484	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
866777000485	putative active site cavity [active]
866777000486	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866777000487	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866777000488	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
866777000489	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
866777000490	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866777000491	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866777000492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000493	dimer interface [polypeptide binding]; other site
866777000494	conserved gate region; other site
866777000495	putative PBP binding loops; other site
866777000496	ABC-ATPase subunit interface; other site
866777000497	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
866777000498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000499	dimer interface [polypeptide binding]; other site
866777000500	conserved gate region; other site
866777000501	putative PBP binding loops; other site
866777000502	ABC-ATPase subunit interface; other site
866777000503	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
866777000504	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777000505	Walker A/P-loop; other site
866777000506	ATP binding site [chemical binding]; other site
866777000507	Q-loop/lid; other site
866777000508	ABC transporter signature motif; other site
866777000509	Walker B; other site
866777000510	D-loop; other site
866777000511	H-loop/switch region; other site
866777000512	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
866777000513	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
866777000514	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777000515	Walker A/P-loop; other site
866777000516	ATP binding site [chemical binding]; other site
866777000517	Q-loop/lid; other site
866777000518	ABC transporter signature motif; other site
866777000519	Walker B; other site
866777000520	D-loop; other site
866777000521	H-loop/switch region; other site
866777000522	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866777000523	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866777000524	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
866777000525	inhibitor site; inhibition site
866777000526	active site
866777000527	dimer interface [polypeptide binding]; other site
866777000528	catalytic residue [active]
866777000529	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866777000530	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
866777000531	active site
866777000532	trimer interface [polypeptide binding]; other site
866777000533	allosteric site; other site
866777000534	active site lid [active]
866777000535	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866777000536	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
866777000537	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
866777000538	catalytic site [active]
866777000539	Asp-box motif; other site
866777000540	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
866777000541	AAA domain; Region: AAA_14; pfam13173
866777000542	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866777000543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866777000544	DNA-binding site [nucleotide binding]; DNA binding site
866777000545	FCD domain; Region: FCD; pfam07729
866777000546	2-isopropylmalate synthase; Validated; Region: PRK03739
866777000547	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
866777000548	active site
866777000549	catalytic residues [active]
866777000550	metal binding site [ion binding]; metal-binding site
866777000551	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
866777000552	Transglycosylase; Region: Transgly; pfam00912
866777000553	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866777000554	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866777000555	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
866777000556	active site
866777000557	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
866777000558	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
866777000559	active site
866777000560	interdomain interaction site; other site
866777000561	putative metal-binding site [ion binding]; other site
866777000562	nucleotide binding site [chemical binding]; other site
866777000563	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
866777000564	domain I; other site
866777000565	phosphate binding site [ion binding]; other site
866777000566	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
866777000567	domain II; other site
866777000568	domain III; other site
866777000569	nucleotide binding site [chemical binding]; other site
866777000570	DNA binding groove [nucleotide binding]
866777000571	catalytic site [active]
866777000572	domain IV; other site
866777000573	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
866777000574	thymidylate kinase; Validated; Region: tmk; PRK00698
866777000575	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
866777000576	TMP-binding site; other site
866777000577	ATP-binding site [chemical binding]; other site
866777000578	DNA polymerase III subunit delta'; Validated; Region: PRK07940
866777000579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777000580	Walker A motif; other site
866777000581	ATP binding site [chemical binding]; other site
866777000582	Walker B motif; other site
866777000583	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
866777000584	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000585	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777000586	dimerization interface [polypeptide binding]; other site
866777000587	ligand binding site [chemical binding]; other site
866777000588	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866777000589	dimerization domain swap beta strand [polypeptide binding]; other site
866777000590	regulatory protein interface [polypeptide binding]; other site
866777000591	active site
866777000592	regulatory phosphorylation site [posttranslational modification]; other site
866777000593	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
866777000594	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
866777000595	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866777000596	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866777000597	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
866777000598	substrate binding site [chemical binding]; other site
866777000599	Peptidase family C69; Region: Peptidase_C69; pfam03577
866777000600	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866777000601	Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759
866777000602	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
866777000603	Predicted membrane protein [Function unknown]; Region: COG2246
866777000604	GtrA-like protein; Region: GtrA; pfam04138
866777000605	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
866777000606	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777000607	catalytic core [active]
866777000608	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
866777000609	Protein of unknown function (DUF805); Region: DUF805; pfam05656
866777000610	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
866777000611	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866777000612	HIGH motif; other site
866777000613	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866777000614	active site
866777000615	KMSKS motif; other site
866777000616	Predicted transcriptional regulators [Transcription]; Region: COG1733
866777000617	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866777000618	dimerization interface [polypeptide binding]; other site
866777000619	putative DNA binding site [nucleotide binding]; other site
866777000620	putative Zn2+ binding site [ion binding]; other site
866777000621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866777000622	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866777000623	NAD(P) binding site [chemical binding]; other site
866777000624	active site
866777000625	Divergent AAA domain; Region: AAA_4; pfam04326
866777000626	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
866777000627	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
866777000628	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
866777000629	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777000630	putative substrate translocation pore; other site
866777000631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777000632	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
866777000633	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
866777000634	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
866777000635	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
866777000636	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
866777000637	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
866777000638	putative NADP binding site [chemical binding]; other site
866777000639	active site
866777000640	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
866777000641	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
866777000642	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866777000643	HNH endonuclease; Region: HNH_2; pfam13391
866777000644	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
866777000645	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
866777000646	cofactor binding site; other site
866777000647	DNA binding site [nucleotide binding]
866777000648	substrate interaction site [chemical binding]; other site
866777000649	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
866777000650	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
866777000651	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
866777000652	active site
866777000653	metal binding site [ion binding]; metal-binding site
866777000654	interdomain interaction site; other site
866777000655	AAA domain; Region: AAA_25; pfam13481
866777000656	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866777000657	Walker A motif; other site
866777000658	ATP binding site [chemical binding]; other site
866777000659	Walker B motif; other site
866777000660	Helix-turn-helix domain; Region: HTH_17; cl17695
866777000661	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
866777000662	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866777000663	active site
866777000664	Int/Topo IB signature motif; other site
866777000665	DNA binding site [nucleotide binding]
866777000666	MgtE intracellular N domain; Region: MgtE_N; smart00924
866777000667	Iron permease FTR1 family; Region: FTR1; cl00475
866777000668	Fe2+ transport protein; Region: Iron_transport; pfam10634
866777000669	Predicted membrane protein [Function unknown]; Region: COG4393
866777000670	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
866777000671	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777000672	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
866777000673	FtsX-like permease family; Region: FtsX; pfam02687
866777000674	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
866777000675	FtsX-like permease family; Region: FtsX; pfam02687
866777000676	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777000677	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777000678	Walker A/P-loop; other site
866777000679	ATP binding site [chemical binding]; other site
866777000680	Q-loop/lid; other site
866777000681	ABC transporter signature motif; other site
866777000682	Walker B; other site
866777000683	D-loop; other site
866777000684	H-loop/switch region; other site
866777000685	FMN-binding domain; Region: FMN_bind; cl01081
866777000686	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777000687	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777000688	Predicted membrane protein [Function unknown]; Region: COG1511
866777000689	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
866777000690	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
866777000691	Predicted membrane protein [Function unknown]; Region: COG1511
866777000692	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
866777000693	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
866777000694	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866777000695	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
866777000696	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866777000697	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
866777000698	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
866777000699	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866777000700	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
866777000701	putative active site [active]
866777000702	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
866777000703	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
866777000704	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
866777000705	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
866777000706	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
866777000707	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
866777000708	Peptidase family C69; Region: Peptidase_C69; pfam03577
866777000709	putative glycosyl transferase; Provisional; Region: PRK10073
866777000710	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866777000711	active site
866777000712	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777000713	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777000714	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
866777000715	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
866777000716	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866777000717	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
866777000718	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
866777000719	Nitrogen regulatory protein P-II; Region: P-II; smart00938
866777000720	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866777000721	metal binding triad; other site
866777000722	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
866777000723	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
866777000724	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
866777000725	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
866777000726	replicative DNA helicase; Region: DnaB; TIGR00665
866777000727	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
866777000728	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
866777000729	Walker A motif; other site
866777000730	ATP binding site [chemical binding]; other site
866777000731	Walker B motif; other site
866777000732	DNA binding loops [nucleotide binding]
866777000733	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866777000734	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
866777000735	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
866777000736	catalytic triad [active]
866777000737	Uncharacterized conserved protein [Function unknown]; Region: COG3937
866777000738	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
866777000739	ABC1 family; Region: ABC1; pfam03109
866777000740	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
866777000741	active site
866777000742	ATP binding site [chemical binding]; other site
866777000743	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
866777000744	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
866777000745	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866777000746	catalytic residue [active]
866777000747	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
866777000748	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
866777000749	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777000750	active site
866777000751	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
866777000752	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
866777000753	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
866777000754	dimer interface [polypeptide binding]; other site
866777000755	ssDNA binding site [nucleotide binding]; other site
866777000756	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866777000757	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
866777000758	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
866777000759	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
866777000760	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
866777000761	MULE transposase domain; Region: MULE; pfam10551
866777000762	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866777000763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777000764	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
866777000765	Walker A/P-loop; other site
866777000766	ATP binding site [chemical binding]; other site
866777000767	Q-loop/lid; other site
866777000768	ABC transporter signature motif; other site
866777000769	Walker B; other site
866777000770	D-loop; other site
866777000771	H-loop/switch region; other site
866777000772	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777000773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777000774	phosphorylation site [posttranslational modification]
866777000775	intermolecular recognition site; other site
866777000776	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777000777	DNA binding residues [nucleotide binding]
866777000778	dimerization interface [polypeptide binding]; other site
866777000779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866777000780	glucuronide transporter; Provisional; Region: PRK09848
866777000781	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
866777000782	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
866777000783	amphipathic channel; other site
866777000784	Asn-Pro-Ala signature motifs; other site
866777000785	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
866777000786	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866777000787	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866777000788	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777000789	active site
866777000790	motif I; other site
866777000791	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866777000792	motif II; other site
866777000793	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
866777000794	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
866777000795	putative homodimer interface [polypeptide binding]; other site
866777000796	putative homotetramer interface [polypeptide binding]; other site
866777000797	putative allosteric switch controlling residues; other site
866777000798	putative metal binding site [ion binding]; other site
866777000799	putative homodimer-homodimer interface [polypeptide binding]; other site
866777000800	RmuC family; Region: RmuC; pfam02646
866777000801	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
866777000802	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
866777000803	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
866777000804	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866777000805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777000806	Walker A/P-loop; other site
866777000807	ATP binding site [chemical binding]; other site
866777000808	Q-loop/lid; other site
866777000809	ABC transporter signature motif; other site
866777000810	Walker B; other site
866777000811	D-loop; other site
866777000812	H-loop/switch region; other site
866777000813	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866777000814	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
866777000815	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
866777000816	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
866777000817	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
866777000818	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
866777000819	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
866777000820	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
866777000821	GatB domain; Region: GatB_Yqey; pfam02637
866777000822	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866777000823	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866777000824	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
866777000825	hypothetical protein; Provisional; Region: PRK07208
866777000826	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866777000827	UDP-galactopyranose mutase; Region: GLF; pfam03275
866777000828	transcription termination factor Rho; Provisional; Region: PRK12678
866777000829	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
866777000830	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
866777000831	RNA binding site [nucleotide binding]; other site
866777000832	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866777000833	Walker A motif; other site
866777000834	ATP binding site [chemical binding]; other site
866777000835	Walker B motif; other site
866777000836	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
866777000837	homodimer interface [polypeptide binding]; other site
866777000838	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866777000839	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
866777000840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866777000841	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777000842	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777000843	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777000844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000845	dimer interface [polypeptide binding]; other site
866777000846	conserved gate region; other site
866777000847	putative PBP binding loops; other site
866777000848	ABC-ATPase subunit interface; other site
866777000849	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777000850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000851	dimer interface [polypeptide binding]; other site
866777000852	conserved gate region; other site
866777000853	putative PBP binding loops; other site
866777000854	ABC-ATPase subunit interface; other site
866777000855	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
866777000856	catalytic site [active]
866777000857	chorismate mutase; Provisional; Region: PRK09239
866777000858	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
866777000859	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777000860	active site
866777000861	HIGH motif; other site
866777000862	nucleotide binding site [chemical binding]; other site
866777000863	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777000864	active site
866777000865	KMSKS motif; other site
866777000866	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
866777000867	tRNA binding surface [nucleotide binding]; other site
866777000868	anticodon binding site; other site
866777000869	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
866777000870	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866777000871	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
866777000872	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866777000873	minor groove reading motif; other site
866777000874	helix-hairpin-helix signature motif; other site
866777000875	substrate binding pocket [chemical binding]; other site
866777000876	active site
866777000877	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
866777000878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866777000879	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866777000880	DNA binding site [nucleotide binding]
866777000881	Predicted membrane protein [Function unknown]; Region: COG1971
866777000882	Domain of unknown function DUF; Region: DUF204; pfam02659
866777000883	Domain of unknown function DUF; Region: DUF204; pfam02659
866777000884	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
866777000885	dimer interface [polypeptide binding]; other site
866777000886	substrate binding site [chemical binding]; other site
866777000887	metal binding sites [ion binding]; metal-binding site
866777000888	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
866777000889	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
866777000890	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866777000891	active site
866777000892	homodimer interface [polypeptide binding]; other site
866777000893	catalytic site [active]
866777000894	acceptor binding site [chemical binding]; other site
866777000895	homoserine O-succinyltransferase; Provisional; Region: PRK05368
866777000896	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
866777000897	proposed active site lysine [active]
866777000898	conserved cys residue [active]
866777000899	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
866777000900	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
866777000901	ATP synthase subunit C; Region: ATP-synt_C; cl00466
866777000902	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
866777000903	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
866777000904	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
866777000905	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
866777000906	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866777000907	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
866777000908	beta subunit interaction interface [polypeptide binding]; other site
866777000909	Walker A motif; other site
866777000910	ATP binding site [chemical binding]; other site
866777000911	Walker B motif; other site
866777000912	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866777000913	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
866777000914	core domain interface [polypeptide binding]; other site
866777000915	delta subunit interface [polypeptide binding]; other site
866777000916	epsilon subunit interface [polypeptide binding]; other site
866777000917	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
866777000918	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866777000919	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
866777000920	alpha subunit interaction interface [polypeptide binding]; other site
866777000921	Walker A motif; other site
866777000922	ATP binding site [chemical binding]; other site
866777000923	Walker B motif; other site
866777000924	inhibitor binding site; inhibition site
866777000925	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866777000926	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
866777000927	gamma subunit interface [polypeptide binding]; other site
866777000928	epsilon subunit interface [polypeptide binding]; other site
866777000929	LBP interface [polypeptide binding]; other site
866777000930	hypothetical protein; Provisional; Region: PRK03298
866777000931	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866777000932	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
866777000933	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
866777000934	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
866777000935	putative active site [active]
866777000936	putative metal binding residues [ion binding]; other site
866777000937	signature motif; other site
866777000938	putative dimer interface [polypeptide binding]; other site
866777000939	putative phosphate binding site [ion binding]; other site
866777000940	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
866777000941	homotrimer interaction site [polypeptide binding]; other site
866777000942	putative active site [active]
866777000943	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
866777000944	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
866777000945	putative acyl-acceptor binding pocket; other site
866777000946	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
866777000947	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
866777000948	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
866777000949	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
866777000950	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
866777000951	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866777000952	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866777000953	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
866777000954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866777000955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000956	dimer interface [polypeptide binding]; other site
866777000957	conserved gate region; other site
866777000958	putative PBP binding loops; other site
866777000959	ABC-ATPase subunit interface; other site
866777000960	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
866777000961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777000962	Walker A/P-loop; other site
866777000963	ATP binding site [chemical binding]; other site
866777000964	Q-loop/lid; other site
866777000965	ABC transporter signature motif; other site
866777000966	Walker B; other site
866777000967	D-loop; other site
866777000968	H-loop/switch region; other site
866777000969	TOBE domain; Region: TOBE_2; pfam08402
866777000970	CAAX protease self-immunity; Region: Abi; pfam02517
866777000971	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866777000972	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866777000973	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
866777000974	Aspartase; Region: Aspartase; cd01357
866777000975	active sites [active]
866777000976	tetramer interface [polypeptide binding]; other site
866777000977	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
866777000978	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866777000979	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
866777000980	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866777000981	FeS/SAM binding site; other site
866777000982	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
866777000983	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777000984	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777000985	DNA binding site [nucleotide binding]
866777000986	domain linker motif; other site
866777000987	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777000988	dimerization interface [polypeptide binding]; other site
866777000989	ligand binding site [chemical binding]; other site
866777000990	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
866777000991	Sulfatase; Region: Sulfatase; pfam00884
866777000992	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777000993	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777000994	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777000995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777000996	dimer interface [polypeptide binding]; other site
866777000997	conserved gate region; other site
866777000998	putative PBP binding loops; other site
866777000999	ABC-ATPase subunit interface; other site
866777001000	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777001001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001002	dimer interface [polypeptide binding]; other site
866777001003	conserved gate region; other site
866777001004	putative PBP binding loops; other site
866777001005	ABC-ATPase subunit interface; other site
866777001006	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
866777001007	AAA domain; Region: AAA_14; pfam13173
866777001008	Transposase, Mutator family; Region: Transposase_mut; pfam00872
866777001009	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777001010	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777001011	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
866777001012	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
866777001013	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866777001014	DNA binding site [nucleotide binding]
866777001015	active site
866777001016	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
866777001017	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
866777001018	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
866777001019	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
866777001020	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
866777001021	metal ion-dependent adhesion site (MIDAS); other site
866777001022	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
866777001023	domain interaction interfaces [polypeptide binding]; other site
866777001024	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
866777001025	Cna protein B-type domain; Region: Cna_B; pfam05738
866777001026	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
866777001027	16S/18S rRNA binding site [nucleotide binding]; other site
866777001028	S13e-L30e interaction site [polypeptide binding]; other site
866777001029	25S rRNA binding site [nucleotide binding]; other site
866777001030	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
866777001031	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
866777001032	oligomer interface [polypeptide binding]; other site
866777001033	RNA binding site [nucleotide binding]; other site
866777001034	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
866777001035	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
866777001036	RNase E interface [polypeptide binding]; other site
866777001037	trimer interface [polypeptide binding]; other site
866777001038	active site
866777001039	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
866777001040	putative nucleic acid binding region [nucleotide binding]; other site
866777001041	G-X-X-G motif; other site
866777001042	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
866777001043	RNA binding site [nucleotide binding]; other site
866777001044	domain interface; other site
866777001045	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777001046	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777001047	Walker A/P-loop; other site
866777001048	ATP binding site [chemical binding]; other site
866777001049	Q-loop/lid; other site
866777001050	ABC transporter signature motif; other site
866777001051	Walker B; other site
866777001052	D-loop; other site
866777001053	H-loop/switch region; other site
866777001054	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
866777001055	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
866777001056	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777001057	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777001058	active site
866777001059	catalytic tetrad [active]
866777001060	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
866777001061	active site
866777001062	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777001063	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777001064	DNA binding site [nucleotide binding]
866777001065	domain linker motif; other site
866777001066	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777001067	dimerization interface [polypeptide binding]; other site
866777001068	ligand binding site [chemical binding]; other site
866777001069	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777001070	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777001071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001072	dimer interface [polypeptide binding]; other site
866777001073	conserved gate region; other site
866777001074	putative PBP binding loops; other site
866777001075	ABC-ATPase subunit interface; other site
866777001076	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777001077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001078	dimer interface [polypeptide binding]; other site
866777001079	conserved gate region; other site
866777001080	putative PBP binding loops; other site
866777001081	ABC-ATPase subunit interface; other site
866777001082	HipA N-terminal domain; Region: Couple_hipA; cl11853
866777001083	HipA-like N-terminal domain; Region: HipA_N; pfam07805
866777001084	HipA-like C-terminal domain; Region: HipA_C; pfam07804
866777001085	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
866777001086	RimM N-terminal domain; Region: RimM; pfam01782
866777001087	hypothetical protein; Provisional; Region: PRK02821
866777001088	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
866777001089	G-X-X-G motif; other site
866777001090	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
866777001091	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
866777001092	putative catalytic site [active]
866777001093	putative metal binding site [ion binding]; other site
866777001094	putative phosphate binding site [ion binding]; other site
866777001095	signal recognition particle protein; Provisional; Region: PRK10867
866777001096	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
866777001097	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866777001098	P loop; other site
866777001099	GTP binding site [chemical binding]; other site
866777001100	Signal peptide binding domain; Region: SRP_SPB; pfam02978
866777001101	Cation efflux family; Region: Cation_efflux; pfam01545
866777001102	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
866777001103	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866777001104	active site
866777001105	HIGH motif; other site
866777001106	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866777001107	KMSKS motif; other site
866777001108	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
866777001109	tRNA binding surface [nucleotide binding]; other site
866777001110	anticodon binding site; other site
866777001111	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
866777001112	catalytic triad [active]
866777001113	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777001114	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866777001115	ABC transporter; Region: ABC_tran_2; pfam12848
866777001116	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777001117	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866777001118	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
866777001119	oligomeric interface; other site
866777001120	putative active site [active]
866777001121	homodimer interface [polypeptide binding]; other site
866777001122	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
866777001123	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
866777001124	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
866777001125	putative valine binding site [chemical binding]; other site
866777001126	dimer interface [polypeptide binding]; other site
866777001127	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
866777001128	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
866777001129	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866777001130	PYR/PP interface [polypeptide binding]; other site
866777001131	dimer interface [polypeptide binding]; other site
866777001132	TPP binding site [chemical binding]; other site
866777001133	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866777001134	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
866777001135	TPP-binding site [chemical binding]; other site
866777001136	dimer interface [polypeptide binding]; other site
866777001137	ribonuclease III; Reviewed; Region: rnc; PRK00102
866777001138	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
866777001139	dimerization interface [polypeptide binding]; other site
866777001140	active site
866777001141	metal binding site [ion binding]; metal-binding site
866777001142	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
866777001143	dsRNA binding site [nucleotide binding]; other site
866777001144	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
866777001145	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
866777001146	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
866777001147	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
866777001148	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
866777001149	active site
866777001150	(T/H)XGH motif; other site
866777001151	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
866777001152	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777001153	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777001154	active site
866777001155	catalytic tetrad [active]
866777001156	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
866777001157	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
866777001158	DNA binding residues [nucleotide binding]
866777001159	putative dimer interface [polypeptide binding]; other site
866777001160	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
866777001161	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
866777001162	active site
866777001163	ribonuclease PH; Reviewed; Region: rph; PRK00173
866777001164	Ribonuclease PH; Region: RNase_PH_bact; cd11362
866777001165	hexamer interface [polypeptide binding]; other site
866777001166	active site
866777001167	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
866777001168	active site
866777001169	dimerization interface [polypeptide binding]; other site
866777001170	Membrane transport protein; Region: Mem_trans; cl09117
866777001171	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
866777001172	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
866777001173	active site
866777001174	dimer interface [polypeptide binding]; other site
866777001175	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
866777001176	dimer interface [polypeptide binding]; other site
866777001177	active site
866777001178	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
866777001179	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
866777001180	Walker A/P-loop; other site
866777001181	ATP binding site [chemical binding]; other site
866777001182	Q-loop/lid; other site
866777001183	ABC transporter signature motif; other site
866777001184	Walker B; other site
866777001185	D-loop; other site
866777001186	H-loop/switch region; other site
866777001187	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
866777001188	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
866777001189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001190	dimer interface [polypeptide binding]; other site
866777001191	conserved gate region; other site
866777001192	putative PBP binding loops; other site
866777001193	ABC-ATPase subunit interface; other site
866777001194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001195	dimer interface [polypeptide binding]; other site
866777001196	conserved gate region; other site
866777001197	putative PBP binding loops; other site
866777001198	ABC-ATPase subunit interface; other site
866777001199	ykoK leader
866777001200	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
866777001201	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
866777001202	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866777001203	Catalytic site [active]
866777001204	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
866777001205	RNA/DNA hybrid binding site [nucleotide binding]; other site
866777001206	active site
866777001207	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777001208	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777001209	DNA binding site [nucleotide binding]
866777001210	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
866777001211	ligand binding site [chemical binding]; other site
866777001212	dimerization interface (open form) [polypeptide binding]; other site
866777001213	dimerization interface (closed form) [polypeptide binding]; other site
866777001214	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
866777001215	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
866777001216	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
866777001217	acyl-activating enzyme (AAE) consensus motif; other site
866777001218	putative AMP binding site [chemical binding]; other site
866777001219	putative active site [active]
866777001220	putative CoA binding site [chemical binding]; other site
866777001221	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
866777001222	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777001223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777001224	Walker A/P-loop; other site
866777001225	ATP binding site [chemical binding]; other site
866777001226	Q-loop/lid; other site
866777001227	ABC transporter signature motif; other site
866777001228	Walker B; other site
866777001229	D-loop; other site
866777001230	H-loop/switch region; other site
866777001231	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866777001232	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777001233	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777001234	Walker A/P-loop; other site
866777001235	ATP binding site [chemical binding]; other site
866777001236	Q-loop/lid; other site
866777001237	ABC transporter signature motif; other site
866777001238	Walker B; other site
866777001239	D-loop; other site
866777001240	H-loop/switch region; other site
866777001241	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777001242	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777001243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001244	dimer interface [polypeptide binding]; other site
866777001245	conserved gate region; other site
866777001246	putative PBP binding loops; other site
866777001247	ABC-ATPase subunit interface; other site
866777001248	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777001249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001250	dimer interface [polypeptide binding]; other site
866777001251	conserved gate region; other site
866777001252	putative PBP binding loops; other site
866777001253	ABC-ATPase subunit interface; other site
866777001254	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
866777001255	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
866777001256	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
866777001257	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
866777001258	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777001259	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777001260	DNA binding site [nucleotide binding]
866777001261	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777001262	ligand binding site [chemical binding]; other site
866777001263	dimerization interface [polypeptide binding]; other site
866777001264	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745
866777001265	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
866777001266	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
866777001267	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777001268	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777001269	active site
866777001270	catalytic tetrad [active]
866777001271	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
866777001272	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
866777001273	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
866777001274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001275	putative substrate translocation pore; other site
866777001276	D-galactonate transporter; Region: 2A0114; TIGR00893
866777001277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001278	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
866777001279	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
866777001280	Bacterial sugar transferase; Region: Bac_transf; pfam02397
866777001281	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866777001282	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
866777001283	active site
866777001284	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
866777001285	Integrase core domain; Region: rve; pfam00665
866777001286	transposase/IS protein; Provisional; Region: PRK09183
866777001287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777001288	Walker A motif; other site
866777001289	ATP binding site [chemical binding]; other site
866777001290	Walker B motif; other site
866777001291	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866777001292	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
866777001293	putative ADP-binding pocket [chemical binding]; other site
866777001294	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866777001295	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
866777001296	putative ADP-binding pocket [chemical binding]; other site
866777001297	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
866777001298	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
866777001299	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866777001300	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866777001301	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866777001302	active site
866777001303	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
866777001304	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
866777001305	dimer interface [polypeptide binding]; other site
866777001306	tetramer interface [polypeptide binding]; other site
866777001307	PYR/PP interface [polypeptide binding]; other site
866777001308	TPP binding site [chemical binding]; other site
866777001309	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
866777001310	TPP-binding site [chemical binding]; other site
866777001311	Integrase core domain; Region: rve_2; pfam13333
866777001312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
866777001313	Integrase core domain; Region: rve; pfam00665
866777001314	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866777001315	Fic family protein [Function unknown]; Region: COG3177
866777001316	Fic/DOC family; Region: Fic; pfam02661
866777001317	S-adenosylmethionine synthetase; Validated; Region: PRK05250
866777001318	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
866777001319	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
866777001320	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
866777001321	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
866777001322	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
866777001323	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
866777001324	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
866777001325	putative active site [active]
866777001326	substrate binding site [chemical binding]; other site
866777001327	putative cosubstrate binding site; other site
866777001328	catalytic site [active]
866777001329	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
866777001330	substrate binding site [chemical binding]; other site
866777001331	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
866777001332	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
866777001333	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777001334	primosome assembly protein PriA; Provisional; Region: PRK14873
866777001335	phosphoserine phosphatase SerB; Region: serB; TIGR00338
866777001336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777001337	motif II; other site
866777001338	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866777001339	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866777001340	proteasome ATPase; Region: pup_AAA; TIGR03689
866777001341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777001342	Walker A motif; other site
866777001343	ATP binding site [chemical binding]; other site
866777001344	Walker B motif; other site
866777001345	arginine finger; other site
866777001346	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
866777001347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777001348	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866777001349	HTH domain; Region: HTH_11; pfam08279
866777001350	PRD domain; Region: PRD; pfam00874
866777001351	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866777001352	active site
866777001353	P-loop; other site
866777001354	phosphorylation site [posttranslational modification]
866777001355	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
866777001356	active site
866777001357	phosphorylation site [posttranslational modification]
866777001358	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866777001359	active site
866777001360	P-loop; other site
866777001361	phosphorylation site [posttranslational modification]
866777001362	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
866777001363	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
866777001364	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866777001365	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866777001366	substrate binding site [chemical binding]; other site
866777001367	hexamer interface [polypeptide binding]; other site
866777001368	metal binding site [ion binding]; metal-binding site
866777001369	Pup-ligase protein; Region: Pup_ligase; cl15463
866777001370	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
866777001371	active site
866777001372	ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687
866777001373	Pup-ligase protein; Region: Pup_ligase; cl15463
866777001374	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866777001375	IHF dimer interface [polypeptide binding]; other site
866777001376	IHF - DNA interface [nucleotide binding]; other site
866777001377	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
866777001378	adenylosuccinate lyase; Provisional; Region: PRK09285
866777001379	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
866777001380	tetramer interface [polypeptide binding]; other site
866777001381	active site
866777001382	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
866777001383	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
866777001384	metal ion-dependent adhesion site (MIDAS); other site
866777001385	von Willebrand factor type A domain; Region: VWA_2; pfam13519
866777001386	Protein of unknown function DUF58; Region: DUF58; pfam01882
866777001387	MoxR-like ATPases [General function prediction only]; Region: COG0714
866777001388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866777001389	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
866777001390	ligand binding site [chemical binding]; other site
866777001391	active site
866777001392	UGI interface [polypeptide binding]; other site
866777001393	catalytic site [active]
866777001394	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
866777001395	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866777001396	DNA-binding site [nucleotide binding]; DNA binding site
866777001397	RNA-binding motif; other site
866777001398	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
866777001399	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
866777001400	ring oligomerisation interface [polypeptide binding]; other site
866777001401	ATP/Mg binding site [chemical binding]; other site
866777001402	stacking interactions; other site
866777001403	hinge regions; other site
866777001404	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
866777001405	Repair protein; Region: Repair_PSII; cl01535
866777001406	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866777001407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777001408	active site
866777001409	phosphorylation site [posttranslational modification]
866777001410	intermolecular recognition site; other site
866777001411	dimerization interface [polypeptide binding]; other site
866777001412	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866777001413	DNA binding site [nucleotide binding]
866777001414	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866777001415	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866777001416	dimerization interface [polypeptide binding]; other site
866777001417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866777001418	dimer interface [polypeptide binding]; other site
866777001419	phosphorylation site [posttranslational modification]
866777001420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777001421	ATP binding site [chemical binding]; other site
866777001422	Mg2+ binding site [ion binding]; other site
866777001423	G-X-G motif; other site
866777001424	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866777001425	DNA-binding site [nucleotide binding]; DNA binding site
866777001426	RNA-binding motif; other site
866777001427	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
866777001428	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866777001429	Ligand Binding Site [chemical binding]; other site
866777001430	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866777001431	Ligand Binding Site [chemical binding]; other site
866777001432	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
866777001433	Clp amino terminal domain; Region: Clp_N; pfam02861
866777001434	Clp amino terminal domain; Region: Clp_N; pfam02861
866777001435	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777001436	Walker A motif; other site
866777001437	ATP binding site [chemical binding]; other site
866777001438	Walker B motif; other site
866777001439	arginine finger; other site
866777001440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777001441	Walker A motif; other site
866777001442	ATP binding site [chemical binding]; other site
866777001443	Walker B motif; other site
866777001444	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866777001445	Cupin domain; Region: Cupin_2; pfam07883
866777001446	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866777001447	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866777001448	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
866777001449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001450	putative substrate translocation pore; other site
866777001451	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
866777001452	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
866777001453	substrate binding pocket [chemical binding]; other site
866777001454	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
866777001455	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866777001456	active site
866777001457	metal binding site [ion binding]; metal-binding site
866777001458	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866777001459	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
866777001460	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
866777001461	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
866777001462	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
866777001463	dimer interface [polypeptide binding]; other site
866777001464	motif 1; other site
866777001465	active site
866777001466	motif 2; other site
866777001467	motif 3; other site
866777001468	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
866777001469	anticodon binding site; other site
866777001470	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
866777001471	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
866777001472	dimer interface [polypeptide binding]; other site
866777001473	anticodon binding site; other site
866777001474	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866777001475	motif 1; other site
866777001476	dimer interface [polypeptide binding]; other site
866777001477	active site
866777001478	motif 2; other site
866777001479	GAD domain; Region: GAD; pfam02938
866777001480	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866777001481	active site
866777001482	motif 3; other site
866777001483	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
866777001484	putative deacylase active site [active]
866777001485	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866777001486	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866777001487	Walker A/P-loop; other site
866777001488	ATP binding site [chemical binding]; other site
866777001489	Q-loop/lid; other site
866777001490	ABC transporter signature motif; other site
866777001491	Walker B; other site
866777001492	D-loop; other site
866777001493	H-loop/switch region; other site
866777001494	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866777001495	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866777001496	substrate binding pocket [chemical binding]; other site
866777001497	membrane-bound complex binding site; other site
866777001498	hinge residues; other site
866777001499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001500	dimer interface [polypeptide binding]; other site
866777001501	conserved gate region; other site
866777001502	ABC-ATPase subunit interface; other site
866777001503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001504	dimer interface [polypeptide binding]; other site
866777001505	conserved gate region; other site
866777001506	putative PBP binding loops; other site
866777001507	ABC-ATPase subunit interface; other site
866777001508	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
866777001509	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866777001510	active site
866777001511	LysE type translocator; Region: LysE; cl00565
866777001512	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866777001513	DNA-binding site [nucleotide binding]; DNA binding site
866777001514	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
866777001515	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777001516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777001517	homodimer interface [polypeptide binding]; other site
866777001518	catalytic residue [active]
866777001519	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
866777001520	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777001521	ATP binding site [chemical binding]; other site
866777001522	putative Mg++ binding site [ion binding]; other site
866777001523	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777001524	nucleotide binding region [chemical binding]; other site
866777001525	ATP-binding site [chemical binding]; other site
866777001526	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
866777001527	recombination factor protein RarA; Reviewed; Region: PRK13342
866777001528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777001529	Walker A motif; other site
866777001530	ATP binding site [chemical binding]; other site
866777001531	Walker B motif; other site
866777001532	arginine finger; other site
866777001533	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
866777001534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001535	putative substrate translocation pore; other site
866777001536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001537	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
866777001538	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866777001539	NAD binding site [chemical binding]; other site
866777001540	ligand binding site [chemical binding]; other site
866777001541	catalytic site [active]
866777001542	Membrane protein of unknown function; Region: DUF360; pfam04020
866777001543	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
866777001544	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866777001545	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
866777001546	Walker A/P-loop; other site
866777001547	ATP binding site [chemical binding]; other site
866777001548	Q-loop/lid; other site
866777001549	ABC transporter signature motif; other site
866777001550	Walker B; other site
866777001551	D-loop; other site
866777001552	H-loop/switch region; other site
866777001553	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866777001554	Walker A/P-loop; other site
866777001555	ATP binding site [chemical binding]; other site
866777001556	Q-loop/lid; other site
866777001557	ABC transporter signature motif; other site
866777001558	Walker B; other site
866777001559	D-loop; other site
866777001560	H-loop/switch region; other site
866777001561	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866777001562	Predicted membrane protein [Function unknown]; Region: COG3601
866777001563	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866777001564	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866777001565	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
866777001566	Probable Catalytic site; other site
866777001567	Nitroreductase family; Region: Nitroreductase; pfam00881
866777001568	FMN binding site [chemical binding]; other site
866777001569	dimer interface [polypeptide binding]; other site
866777001570	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
866777001571	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777001572	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866777001573	nucleotide binding site [chemical binding]; other site
866777001574	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
866777001575	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
866777001576	substrate binding [chemical binding]; other site
866777001577	active site
866777001578	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
866777001579	galactoside permease; Reviewed; Region: lacY; PRK09528
866777001580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001581	putative substrate translocation pore; other site
866777001582	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777001583	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777001584	DNA binding site [nucleotide binding]
866777001585	domain linker motif; other site
866777001586	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
866777001587	putative dimerization interface [polypeptide binding]; other site
866777001588	putative ligand binding site [chemical binding]; other site
866777001589	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
866777001590	serpin-like protein; Provisional; Region: PHA02660
866777001591	reactive center loop; other site
866777001592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777001593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777001594	active site
866777001595	phosphorylation site [posttranslational modification]
866777001596	intermolecular recognition site; other site
866777001597	dimerization interface [polypeptide binding]; other site
866777001598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777001599	DNA binding residues [nucleotide binding]
866777001600	dimerization interface [polypeptide binding]; other site
866777001601	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866777001602	benzoate transport; Region: 2A0115; TIGR00895
866777001603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001604	putative substrate translocation pore; other site
866777001605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777001606	putative substrate translocation pore; other site
866777001607	Domain of unknown function DUF77; Region: DUF77; pfam01910
866777001608	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
866777001609	substrate binding site [chemical binding]; other site
866777001610	dimer interface [polypeptide binding]; other site
866777001611	ATP binding site [chemical binding]; other site
866777001612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777001613	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
866777001614	Walker A motif; other site
866777001615	ATP binding site [chemical binding]; other site
866777001616	Walker B motif; other site
866777001617	arginine finger; other site
866777001618	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
866777001619	thiamine phosphate binding site [chemical binding]; other site
866777001620	active site
866777001621	pyrophosphate binding site [ion binding]; other site
866777001622	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
866777001623	ThiC-associated domain; Region: ThiC-associated; pfam13667
866777001624	ThiC family; Region: ThiC; pfam01964
866777001625	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
866777001626	substrate binding site [chemical binding]; other site
866777001627	multimerization interface [polypeptide binding]; other site
866777001628	ATP binding site [chemical binding]; other site
866777001629	glycyl-tRNA synthetase; Provisional; Region: PRK04173
866777001630	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866777001631	motif 1; other site
866777001632	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
866777001633	active site
866777001634	motif 2; other site
866777001635	motif 3; other site
866777001636	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
866777001637	anticodon binding site; other site
866777001638	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
866777001639	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
866777001640	FMN binding site [chemical binding]; other site
866777001641	active site
866777001642	catalytic residues [active]
866777001643	substrate binding site [chemical binding]; other site
866777001644	cell division protein FtsZ; Validated; Region: PRK09330
866777001645	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
866777001646	nucleotide binding site [chemical binding]; other site
866777001647	SulA interaction site; other site
866777001648	Protein of unknown function (DUF552); Region: DUF552; pfam04472
866777001649	YGGT family; Region: YGGT; pfam02325
866777001650	DivIVA protein; Region: DivIVA; pfam05103
866777001651	DivIVA domain; Region: DivI1A_domain; TIGR03544
866777001652	lipoprotein signal peptidase; Provisional; Region: PRK14771
866777001653	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866777001654	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866777001655	active site
866777001656	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866777001657	putative Zn2+ binding site [ion binding]; other site
866777001658	WYL domain; Region: WYL; pfam13280
866777001659	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
866777001660	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
866777001661	active site
866777001662	PHP Thumb interface [polypeptide binding]; other site
866777001663	metal binding site [ion binding]; metal-binding site
866777001664	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
866777001665	generic binding surface II; other site
866777001666	generic binding surface I; other site
866777001667	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
866777001668	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777001669	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777001670	active site
866777001671	catalytic tetrad [active]
866777001672	myosin-cross-reactive antigen; Provisional; Region: PRK13977
866777001673	unresolved repeat; rRNA operon with unverified consensus
866777001674	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
866777001675	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
866777001676	metal binding site [ion binding]; metal-binding site
866777001677	substrate binding pocket [chemical binding]; other site
866777001678	short chain dehydrogenase; Provisional; Region: PRK08628
866777001679	classical (c) SDRs; Region: SDR_c; cd05233
866777001680	NAD(P) binding site [chemical binding]; other site
866777001681	active site
866777001682	Amidohydrolase; Region: Amidohydro_2; pfam04909
866777001683	active site
866777001684	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866777001685	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
866777001686	inhibitor site; inhibition site
866777001687	active site
866777001688	dimer interface [polypeptide binding]; other site
866777001689	catalytic residue [active]
866777001690	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777001691	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777001692	active site
866777001693	catalytic tetrad [active]
866777001694	Acylphosphatase; Region: Acylphosphatase; cl00551
866777001695	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
866777001696	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
866777001697	NAD binding site [chemical binding]; other site
866777001698	dimerization interface [polypeptide binding]; other site
866777001699	product binding site; other site
866777001700	substrate binding site [chemical binding]; other site
866777001701	zinc binding site [ion binding]; other site
866777001702	catalytic residues [active]
866777001703	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
866777001704	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777001705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777001706	homodimer interface [polypeptide binding]; other site
866777001707	catalytic residue [active]
866777001708	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
866777001709	putative active site pocket [active]
866777001710	4-fold oligomerization interface [polypeptide binding]; other site
866777001711	metal binding residues [ion binding]; metal-binding site
866777001712	3-fold/trimer interface [polypeptide binding]; other site
866777001713	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
866777001714	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
866777001715	putative active site [active]
866777001716	oxyanion strand; other site
866777001717	catalytic triad [active]
866777001718	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
866777001719	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
866777001720	catalytic residues [active]
866777001721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
866777001722	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
866777001723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
866777001724	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
866777001725	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
866777001726	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
866777001727	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
866777001728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777001729	ATP binding site [chemical binding]; other site
866777001730	putative Mg++ binding site [ion binding]; other site
866777001731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777001732	nucleotide binding region [chemical binding]; other site
866777001733	ATP-binding site [chemical binding]; other site
866777001734	Helicase associated domain (HA2); Region: HA2; pfam04408
866777001735	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
866777001736	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
866777001737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777001738	S-adenosylmethionine binding site [chemical binding]; other site
866777001739	GTPases [General function prediction only]; Region: HflX; COG2262
866777001740	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
866777001741	HflX GTPase family; Region: HflX; cd01878
866777001742	G1 box; other site
866777001743	GTP/Mg2+ binding site [chemical binding]; other site
866777001744	Switch I region; other site
866777001745	G2 box; other site
866777001746	G3 box; other site
866777001747	Switch II region; other site
866777001748	G4 box; other site
866777001749	G5 box; other site
866777001750	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
866777001751	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
866777001752	NAD binding site [chemical binding]; other site
866777001753	dimer interface [polypeptide binding]; other site
866777001754	substrate binding site [chemical binding]; other site
866777001755	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866777001756	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
866777001757	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
866777001758	LexA repressor; Validated; Region: PRK00215
866777001759	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
866777001760	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866777001761	Catalytic site [active]
866777001762	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866777001763	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
866777001764	ATP cone domain; Region: ATP-cone; pfam03477
866777001765	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
866777001766	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
866777001767	ligand binding site [chemical binding]; other site
866777001768	NAD binding site [chemical binding]; other site
866777001769	tetramer interface [polypeptide binding]; other site
866777001770	catalytic site [active]
866777001771	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
866777001772	L-serine binding site [chemical binding]; other site
866777001773	ACT domain interface; other site
866777001774	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
866777001775	Part of AAA domain; Region: AAA_19; pfam13245
866777001776	Family description; Region: UvrD_C_2; pfam13538
866777001777	cell division protein MraZ; Reviewed; Region: PRK00326
866777001778	MraZ protein; Region: MraZ; pfam02381
866777001779	MraZ protein; Region: MraZ; pfam02381
866777001780	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
866777001781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777001782	S-adenosylmethionine binding site [chemical binding]; other site
866777001783	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
866777001784	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866777001785	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866777001786	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
866777001787	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
866777001788	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866777001789	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866777001790	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866777001791	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
866777001792	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
866777001793	Mg++ binding site [ion binding]; other site
866777001794	putative catalytic motif [active]
866777001795	putative substrate binding site [chemical binding]; other site
866777001796	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
866777001797	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
866777001798	NAD binding site [chemical binding]; other site
866777001799	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866777001800	cell division protein FtsW; Region: ftsW; TIGR02614
866777001801	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
866777001802	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
866777001803	active site
866777001804	homodimer interface [polypeptide binding]; other site
866777001805	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
866777001806	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866777001807	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866777001808	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866777001809	cell division protein FtsQ; Provisional; Region: PRK05529
866777001810	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
866777001811	Cell division protein FtsQ; Region: FtsQ; pfam03799
866777001812	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
866777001813	putative active site [active]
866777001814	dimerization interface [polypeptide binding]; other site
866777001815	putative tRNAtyr binding site [nucleotide binding]; other site
866777001816	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
866777001817	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777001818	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
866777001819	putative substrate binding site [chemical binding]; other site
866777001820	putative ATP binding site [chemical binding]; other site
866777001821	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866777001822	putative DNA binding site [nucleotide binding]; other site
866777001823	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866777001824	putative Zn2+ binding site [ion binding]; other site
866777001825	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777001826	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866777001827	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777001828	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777001829	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866777001830	nucleotide binding site [chemical binding]; other site
866777001831	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777001832	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777001833	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866777001834	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
866777001835	active site
866777001836	trimer interface [polypeptide binding]; other site
866777001837	allosteric site; other site
866777001838	active site lid [active]
866777001839	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866777001840	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
866777001841	Amidohydrolase; Region: Amidohydro_4; pfam13147
866777001842	active site
866777001843	dimer interface [polypeptide binding]; other site
866777001844	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
866777001845	nudix motif; other site
866777001846	proline aminopeptidase P II; Provisional; Region: PRK10879
866777001847	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
866777001848	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
866777001849	active site
866777001850	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
866777001851	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866777001852	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
866777001853	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
866777001854	Walker A/P-loop; other site
866777001855	ATP binding site [chemical binding]; other site
866777001856	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
866777001857	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
866777001858	ABC transporter signature motif; other site
866777001859	Walker B; other site
866777001860	D-loop; other site
866777001861	H-loop/switch region; other site
866777001862	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
866777001863	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
866777001864	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866777001865	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866777001866	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866777001867	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
866777001868	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866777001869	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866777001870	DNA binding residues [nucleotide binding]
866777001871	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
866777001872	active site
866777001873	catalytic residues [active]
866777001874	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
866777001875	active site
866777001876	catalytic residues [active]
866777001877	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
866777001878	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
866777001879	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
866777001880	putative deacylase active site [active]
866777001881	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
866777001882	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
866777001883	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866777001884	Thiamine pyrophosphokinase; Region: TPK; cd07995
866777001885	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
866777001886	active site
866777001887	dimerization interface [polypeptide binding]; other site
866777001888	thiamine binding site [chemical binding]; other site
866777001889	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
866777001890	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
866777001891	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
866777001892	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
866777001893	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
866777001894	23S rRNA binding site [nucleotide binding]; other site
866777001895	L21 binding site [polypeptide binding]; other site
866777001896	L13 binding site [polypeptide binding]; other site
866777001897	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
866777001898	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
866777001899	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866777001900	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
866777001901	fructuronate transporter; Provisional; Region: PRK10034; cl15264
866777001902	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
866777001903	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
866777001904	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
866777001905	active site
866777001906	Int/Topo IB signature motif; other site
866777001907	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
866777001908	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866777001909	P-loop; other site
866777001910	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866777001911	Magnesium ion binding site [ion binding]; other site
866777001912	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866777001913	Magnesium ion binding site [ion binding]; other site
866777001914	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
866777001915	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
866777001916	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
866777001917	nudix motif; other site
866777001918	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
866777001919	quinolinate synthetase; Provisional; Region: PRK09375
866777001920	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
866777001921	L-aspartate oxidase; Provisional; Region: PRK06175
866777001922	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866777001923	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
866777001924	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
866777001925	dimerization interface [polypeptide binding]; other site
866777001926	active site
866777001927	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
866777001928	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866777001929	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866777001930	catalytic residue [active]
866777001931	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777001932	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777001933	Walker A/P-loop; other site
866777001934	ATP binding site [chemical binding]; other site
866777001935	Q-loop/lid; other site
866777001936	ABC transporter signature motif; other site
866777001937	Walker B; other site
866777001938	D-loop; other site
866777001939	H-loop/switch region; other site
866777001940	Predicted transcriptional regulators [Transcription]; Region: COG1695
866777001941	Transcriptional regulator PadR-like family; Region: PadR; cl17335
866777001942	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
866777001943	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
866777001944	G1 box; other site
866777001945	putative GEF interaction site [polypeptide binding]; other site
866777001946	GTP/Mg2+ binding site [chemical binding]; other site
866777001947	Switch I region; other site
866777001948	G2 box; other site
866777001949	G3 box; other site
866777001950	Switch II region; other site
866777001951	G4 box; other site
866777001952	G5 box; other site
866777001953	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
866777001954	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
866777001955	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
866777001956	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
866777001957	Prephenate dehydratase; Region: PDT; pfam00800
866777001958	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
866777001959	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
866777001960	prephenate dehydrogenase; Validated; Region: PRK08507
866777001961	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777001962	FtsX-like permease family; Region: FtsX; pfam02687
866777001963	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777001964	FtsX-like permease family; Region: FtsX; pfam02687
866777001965	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777001966	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777001967	Walker A/P-loop; other site
866777001968	ATP binding site [chemical binding]; other site
866777001969	Q-loop/lid; other site
866777001970	ABC transporter signature motif; other site
866777001971	Walker B; other site
866777001972	D-loop; other site
866777001973	H-loop/switch region; other site
866777001974	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
866777001975	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866777001976	active site
866777001977	DNA binding site [nucleotide binding]
866777001978	Int/Topo IB signature motif; other site
866777001979	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
866777001980	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866777001981	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866777001982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001983	dimer interface [polypeptide binding]; other site
866777001984	conserved gate region; other site
866777001985	putative PBP binding loops; other site
866777001986	ABC-ATPase subunit interface; other site
866777001987	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866777001988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777001989	dimer interface [polypeptide binding]; other site
866777001990	conserved gate region; other site
866777001991	putative PBP binding loops; other site
866777001992	ABC-ATPase subunit interface; other site
866777001993	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777001994	AAA domain; Region: AAA_21; pfam13304
866777001995	Walker A/P-loop; other site
866777001996	ATP binding site [chemical binding]; other site
866777001997	Q-loop/lid; other site
866777001998	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777001999	ABC transporter signature motif; other site
866777002000	Walker B; other site
866777002001	D-loop; other site
866777002002	H-loop/switch region; other site
866777002003	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866777002004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777002005	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
866777002006	Walker A/P-loop; other site
866777002007	ATP binding site [chemical binding]; other site
866777002008	Q-loop/lid; other site
866777002009	ABC transporter signature motif; other site
866777002010	Walker B; other site
866777002011	D-loop; other site
866777002012	H-loop/switch region; other site
866777002013	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866777002014	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
866777002015	putative active site [active]
866777002016	putative catalytic site [active]
866777002017	putative DNA binding site [nucleotide binding]; other site
866777002018	putative phosphate binding site [ion binding]; other site
866777002019	metal binding site A [ion binding]; metal-binding site
866777002020	putative AP binding site [nucleotide binding]; other site
866777002021	putative metal binding site B [ion binding]; other site
866777002022	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
866777002023	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
866777002024	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
866777002025	TRAM domain; Region: TRAM; cl01282
866777002026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777002027	S-adenosylmethionine binding site [chemical binding]; other site
866777002028	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
866777002029	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866777002030	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777002031	motif II; other site
866777002032	aconitate hydratase; Validated; Region: PRK09277
866777002033	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
866777002034	substrate binding site [chemical binding]; other site
866777002035	ligand binding site [chemical binding]; other site
866777002036	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
866777002037	substrate binding site [chemical binding]; other site
866777002038	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866777002039	Coenzyme A binding pocket [chemical binding]; other site
866777002040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777002041	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777002042	active site
866777002043	phosphorylation site [posttranslational modification]
866777002044	intermolecular recognition site; other site
866777002045	dimerization interface [polypeptide binding]; other site
866777002046	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777002047	DNA binding residues [nucleotide binding]
866777002048	dimerization interface [polypeptide binding]; other site
866777002049	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
866777002050	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
866777002051	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866777002052	EamA-like transporter family; Region: EamA; pfam00892
866777002053	EamA-like transporter family; Region: EamA; pfam00892
866777002054	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
866777002055	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866777002056	synthetase active site [active]
866777002057	NTP binding site [chemical binding]; other site
866777002058	metal binding site [ion binding]; metal-binding site
866777002059	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
866777002060	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
866777002061	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866777002062	FeS/SAM binding site; other site
866777002063	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
866777002064	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
866777002065	Fic/DOC family; Region: Fic; cl00960
866777002066	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
866777002067	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
866777002068	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
866777002069	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
866777002070	Competence-damaged protein; Region: CinA; pfam02464
866777002071	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866777002072	sequence-specific DNA binding site [nucleotide binding]; other site
866777002073	salt bridge; other site
866777002074	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
866777002075	recombinase A; Provisional; Region: recA; PRK09354
866777002076	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
866777002077	hexamer interface [polypeptide binding]; other site
866777002078	Walker A motif; other site
866777002079	ATP binding site [chemical binding]; other site
866777002080	Walker B motif; other site
866777002081	recombination regulator RecX; Reviewed; Region: recX; PRK00117
866777002082	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
866777002083	30S subunit binding site; other site
866777002084	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
866777002085	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777002086	ATP binding site [chemical binding]; other site
866777002087	putative Mg++ binding site [ion binding]; other site
866777002088	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
866777002089	SEC-C motif; Region: SEC-C; pfam02810
866777002090	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
866777002091	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866777002092	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
866777002093	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
866777002094	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
866777002095	putative acyl-acceptor binding pocket; other site
866777002096	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
866777002097	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
866777002098	substrate binding pocket [chemical binding]; other site
866777002099	chain length determination region; other site
866777002100	substrate-Mg2+ binding site; other site
866777002101	catalytic residues [active]
866777002102	aspartate-rich region 1; other site
866777002103	active site lid residues [active]
866777002104	aspartate-rich region 2; other site
866777002105	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
866777002106	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
866777002107	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866777002108	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866777002109	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866777002110	DNA binding residues [nucleotide binding]
866777002111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777002112	Mg2+ binding site [ion binding]; other site
866777002113	G-X-G motif; other site
866777002114	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866777002115	anchoring element; other site
866777002116	dimer interface [polypeptide binding]; other site
866777002117	ATP binding site [chemical binding]; other site
866777002118	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866777002119	active site
866777002120	putative metal-binding site [ion binding]; other site
866777002121	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866777002122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777002123	putative substrate translocation pore; other site
866777002124	D-galactonate transporter; Region: 2A0114; TIGR00893
866777002125	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866777002126	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777002127	substrate binding site [chemical binding]; other site
866777002128	dimer interface [polypeptide binding]; other site
866777002129	ATP binding site [chemical binding]; other site
866777002130	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866777002131	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777002132	ATP binding site [chemical binding]; other site
866777002133	putative Mg++ binding site [ion binding]; other site
866777002134	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777002135	nucleotide binding region [chemical binding]; other site
866777002136	ATP-binding site [chemical binding]; other site
866777002137	DEAD/H associated; Region: DEAD_assoc; pfam08494
866777002138	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
866777002139	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
866777002140	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
866777002141	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866777002142	CAP-like domain; other site
866777002143	active site
866777002144	primary dimer interface [polypeptide binding]; other site
866777002145	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866777002146	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
866777002147	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
866777002148	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
866777002149	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
866777002150	trimer interface [polypeptide binding]; other site
866777002151	active site
866777002152	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
866777002153	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866777002154	Zn2+ binding site [ion binding]; other site
866777002155	Mg2+ binding site [ion binding]; other site
866777002156	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866777002157	synthetase active site [active]
866777002158	NTP binding site [chemical binding]; other site
866777002159	metal binding site [ion binding]; metal-binding site
866777002160	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
866777002161	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
866777002162	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
866777002163	active site
866777002164	HipA-like C-terminal domain; Region: HipA_C; pfam07804
866777002165	Fic family protein [Function unknown]; Region: COG3177
866777002166	Fic/DOC family; Region: Fic; pfam02661
866777002167	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
866777002168	active site
866777002169	catalytic site [active]
866777002170	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
866777002171	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
866777002172	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
866777002173	active site
866777002174	catalytic site [active]
866777002175	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
866777002176	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
866777002177	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777002178	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777002179	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777002180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777002181	dimer interface [polypeptide binding]; other site
866777002182	conserved gate region; other site
866777002183	putative PBP binding loops; other site
866777002184	ABC-ATPase subunit interface; other site
866777002185	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777002186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777002187	dimer interface [polypeptide binding]; other site
866777002188	conserved gate region; other site
866777002189	putative PBP binding loops; other site
866777002190	ABC-ATPase subunit interface; other site
866777002191	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777002192	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777002193	DNA binding site [nucleotide binding]
866777002194	domain linker motif; other site
866777002195	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777002196	ligand binding site [chemical binding]; other site
866777002197	dimerization interface [polypeptide binding]; other site
866777002198	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
866777002199	putative active cleft [active]
866777002200	Uncharacterized conserved protein [Function unknown]; Region: COG3538
866777002201	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
866777002202	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
866777002203	Nitroreductase family; Region: Nitroreductase; pfam00881
866777002204	FMN binding site [chemical binding]; other site
866777002205	dimer interface [polypeptide binding]; other site
866777002206	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
866777002207	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866777002208	EamA-like transporter family; Region: EamA; pfam00892
866777002209	EamA-like transporter family; Region: EamA; pfam00892
866777002210	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
866777002211	Methyltransferase domain; Region: Methyltransf_26; pfam13659
866777002212	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777002213	catalytic core [active]
866777002214	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
866777002215	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
866777002216	Cl binding site [ion binding]; other site
866777002217	oligomer interface [polypeptide binding]; other site
866777002218	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
866777002219	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866777002220	substrate binding pocket [chemical binding]; other site
866777002221	membrane-bound complex binding site; other site
866777002222	hinge residues; other site
866777002223	aminoacyl-tRNA ligase; Region: PLN02563
866777002224	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777002225	active site
866777002226	HIGH motif; other site
866777002227	nucleotide binding site [chemical binding]; other site
866777002228	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777002229	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866777002230	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777002231	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777002232	active site
866777002233	KMSKS motif; other site
866777002234	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
866777002235	tRNA binding surface [nucleotide binding]; other site
866777002236	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
866777002237	Helix-hairpin-helix motif; Region: HHH; pfam00633
866777002238	Competence protein; Region: Competence; pfam03772
866777002239	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
866777002240	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
866777002241	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
866777002242	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
866777002243	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
866777002244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866777002245	Coenzyme A binding pocket [chemical binding]; other site
866777002246	UGMP family protein; Validated; Region: PRK09604
866777002247	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
866777002248	Histidine kinase; Region: HisKA_3; pfam07730
866777002249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777002250	ATP binding site [chemical binding]; other site
866777002251	Mg2+ binding site [ion binding]; other site
866777002252	G-X-G motif; other site
866777002253	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866777002254	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866777002255	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866777002256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777002257	Walker A/P-loop; other site
866777002258	ATP binding site [chemical binding]; other site
866777002259	Q-loop/lid; other site
866777002260	ABC transporter signature motif; other site
866777002261	Walker B; other site
866777002262	D-loop; other site
866777002263	H-loop/switch region; other site
866777002264	Fic/DOC family; Region: Fic; pfam02661
866777002265	Fic/DOC family; Region: Fic; cl00960
866777002266	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866777002267	Peptidase family M23; Region: Peptidase_M23; pfam01551
866777002268	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777002269	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777002270	isocitrate dehydrogenase; Validated; Region: PRK08299
866777002271	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
866777002272	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866777002273	active site
866777002274	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
866777002275	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
866777002276	acyl-activating enzyme (AAE) consensus motif; other site
866777002277	putative AMP binding site [chemical binding]; other site
866777002278	putative active site [active]
866777002279	putative CoA binding site [chemical binding]; other site
866777002280	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
866777002281	active site
866777002282	catalytic residues [active]
866777002283	metal binding site [ion binding]; metal-binding site
866777002284	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
866777002285	rRNA interaction site [nucleotide binding]; other site
866777002286	S8 interaction site; other site
866777002287	putative laminin-1 binding site; other site
866777002288	elongation factor Ts; Provisional; Region: tsf; PRK09377
866777002289	Elongation factor TS; Region: EF_TS; pfam00889
866777002290	Elongation factor TS; Region: EF_TS; pfam00889
866777002291	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
866777002292	putative nucleotide binding site [chemical binding]; other site
866777002293	uridine monophosphate binding site [chemical binding]; other site
866777002294	homohexameric interface [polypeptide binding]; other site
866777002295	ribosome recycling factor; Reviewed; Region: frr; PRK00083
866777002296	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
866777002297	hinge region; other site
866777002298	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
866777002299	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
866777002300	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
866777002301	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866777002302	FeS/SAM binding site; other site
866777002303	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
866777002304	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
866777002305	substrate binding site [chemical binding]; other site
866777002306	glutamase interaction surface [polypeptide binding]; other site
866777002307	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
866777002308	anthranilate synthase component I; Provisional; Region: PRK13571
866777002309	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
866777002310	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
866777002311	Domain of unknown function (DUF1287); Region: DUF1287; cl01519
866777002312	Uncharacterized conserved protein [Function unknown]; Region: COG3189
866777002313	S-methylmethionine transporter; Provisional; Region: PRK11387
866777002314	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
866777002315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
866777002316	RelB antitoxin; Region: RelB; cl01171
866777002317	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777002318	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777002319	Walker A/P-loop; other site
866777002320	ATP binding site [chemical binding]; other site
866777002321	Q-loop/lid; other site
866777002322	ABC transporter signature motif; other site
866777002323	Walker B; other site
866777002324	D-loop; other site
866777002325	H-loop/switch region; other site
866777002326	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
866777002327	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
866777002328	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777002329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777002330	active site
866777002331	phosphorylation site [posttranslational modification]
866777002332	intermolecular recognition site; other site
866777002333	dimerization interface [polypeptide binding]; other site
866777002334	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777002335	DNA binding residues [nucleotide binding]
866777002336	dimerization interface [polypeptide binding]; other site
866777002337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866777002338	Histidine kinase; Region: HisKA_3; pfam07730
866777002339	Abi-like protein; Region: Abi_2; pfam07751
866777002340	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866777002341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866777002342	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866777002343	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866777002344	catalytic residue [active]
866777002345	VanZ like family; Region: VanZ; pfam04892
866777002346	S-methylmethionine transporter; Provisional; Region: PRK11387
866777002347	endonuclease IV; Provisional; Region: PRK01060
866777002348	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
866777002349	AP (apurinic/apyrimidinic) site pocket; other site
866777002350	DNA interaction; other site
866777002351	Metal-binding active site; metal-binding site
866777002352	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
866777002353	bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802
866777002354	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
866777002355	active site
866777002356	ribulose/triose binding site [chemical binding]; other site
866777002357	phosphate binding site [ion binding]; other site
866777002358	substrate (anthranilate) binding pocket [chemical binding]; other site
866777002359	product (indole) binding pocket [chemical binding]; other site
866777002360	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
866777002361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777002362	catalytic residue [active]
866777002363	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
866777002364	substrate binding site [chemical binding]; other site
866777002365	active site
866777002366	catalytic residues [active]
866777002367	heterodimer interface [polypeptide binding]; other site
866777002368	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
866777002369	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866777002370	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866777002371	substrate binding site [chemical binding]; other site
866777002372	hexamer interface [polypeptide binding]; other site
866777002373	metal binding site [ion binding]; metal-binding site
866777002374	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
866777002375	homodimer interface [polypeptide binding]; other site
866777002376	putative metal binding site [ion binding]; other site
866777002377	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
866777002378	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
866777002379	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
866777002380	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
866777002381	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
866777002382	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
866777002383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
866777002384	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
866777002385	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
866777002386	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
866777002387	phosphopeptide binding site; other site
866777002388	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
866777002389	DNA binding residues [nucleotide binding]
866777002390	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866777002391	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
866777002392	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777002393	motif II; other site
866777002394	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
866777002395	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866777002396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777002397	ATP binding site [chemical binding]; other site
866777002398	putative Mg++ binding site [ion binding]; other site
866777002399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777002400	nucleotide binding region [chemical binding]; other site
866777002401	ATP-binding site [chemical binding]; other site
866777002402	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
866777002403	Predicted transcriptional regulator [Transcription]; Region: COG2378
866777002404	WYL domain; Region: WYL; pfam13280
866777002405	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866777002406	active site
866777002407	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866777002408	Eukaryotic phosphomannomutase; Region: PMM; cl17107
866777002409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777002410	bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518
866777002411	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
866777002412	CMP-binding site; other site
866777002413	The sites determining sugar specificity; other site
866777002414	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
866777002415	G1 box; other site
866777002416	GTP/Mg2+ binding site [chemical binding]; other site
866777002417	Switch I region; other site
866777002418	G2 box; other site
866777002419	Switch II region; other site
866777002420	G3 box; other site
866777002421	G4 box; other site
866777002422	G5 box; other site
866777002423	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
866777002424	G1 box; other site
866777002425	GTP/Mg2+ binding site [chemical binding]; other site
866777002426	Switch I region; other site
866777002427	G2 box; other site
866777002428	G3 box; other site
866777002429	Switch II region; other site
866777002430	G4 box; other site
866777002431	G5 box; other site
866777002432	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866777002433	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
866777002434	RNA binding surface [nucleotide binding]; other site
866777002435	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
866777002436	active site
866777002437	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
866777002438	amphipathic channel; other site
866777002439	Asn-Pro-Ala signature motifs; other site
866777002440	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
866777002441	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
866777002442	purine monophosphate binding site [chemical binding]; other site
866777002443	dimer interface [polypeptide binding]; other site
866777002444	putative catalytic residues [active]
866777002445	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
866777002446	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
866777002447	CoA binding domain; Region: CoA_binding; pfam02629
866777002448	CoA-ligase; Region: Ligase_CoA; pfam00549
866777002449	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
866777002450	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
866777002451	CoA-ligase; Region: Ligase_CoA; pfam00549
866777002452	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777002453	active site
866777002454	Preprotein translocase subunit; Region: YajC; pfam02699
866777002455	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
866777002456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777002457	Walker A motif; other site
866777002458	ATP binding site [chemical binding]; other site
866777002459	Walker B motif; other site
866777002460	arginine finger; other site
866777002461	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866777002462	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
866777002463	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
866777002464	RuvA N terminal domain; Region: RuvA_N; pfam01330
866777002465	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
866777002466	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
866777002467	active site
866777002468	putative DNA-binding cleft [nucleotide binding]; other site
866777002469	dimer interface [polypeptide binding]; other site
866777002470	hypothetical protein; Validated; Region: PRK00110
866777002471	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
866777002472	nucleotide binding site/active site [active]
866777002473	HIT family signature motif; other site
866777002474	catalytic residue [active]
866777002475	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
866777002476	thiS-thiF/thiG interaction site; other site
866777002477	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
866777002478	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
866777002479	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
866777002480	active site
866777002481	dimer interface [polypeptide binding]; other site
866777002482	motif 1; other site
866777002483	motif 2; other site
866777002484	motif 3; other site
866777002485	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
866777002486	anticodon binding site; other site
866777002487	PAC2 family; Region: PAC2; pfam09754
866777002488	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
866777002489	Fructosamine kinase; Region: Fructosamin_kin; cl17579
866777002490	Phosphotransferase enzyme family; Region: APH; pfam01636
866777002491	chaperone protein DnaJ; Provisional; Region: PRK14278
866777002492	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866777002493	HSP70 interaction site [polypeptide binding]; other site
866777002494	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
866777002495	Zn binding sites [ion binding]; other site
866777002496	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
866777002497	dimer interface [polypeptide binding]; other site
866777002498	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
866777002499	HTH domain; Region: HTH_11; pfam08279
866777002500	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
866777002501	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866777002502	TPP-binding site [chemical binding]; other site
866777002503	dimer interface [polypeptide binding]; other site
866777002504	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866777002505	PYR/PP interface [polypeptide binding]; other site
866777002506	dimer interface [polypeptide binding]; other site
866777002507	TPP binding site [chemical binding]; other site
866777002508	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866777002509	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
866777002510	putative active site [active]
866777002511	transaldolase; Provisional; Region: PRK03903
866777002512	catalytic residue [active]
866777002513	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
866777002514	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
866777002515	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866777002516	non-specific DNA binding site [nucleotide binding]; other site
866777002517	salt bridge; other site
866777002518	sequence-specific DNA binding site [nucleotide binding]; other site
866777002519	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777002520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777002521	homodimer interface [polypeptide binding]; other site
866777002522	catalytic residue [active]
866777002523	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866777002524	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777002525	active site
866777002526	motif I; other site
866777002527	motif II; other site
866777002528	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866777002529	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
866777002530	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866777002531	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
866777002532	NAD binding site [chemical binding]; other site
866777002533	dimer interface [polypeptide binding]; other site
866777002534	substrate binding site [chemical binding]; other site
866777002535	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
866777002536	triosephosphate isomerase; Provisional; Region: PRK14567
866777002537	substrate binding site [chemical binding]; other site
866777002538	dimer interface [polypeptide binding]; other site
866777002539	catalytic triad [active]
866777002540	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
866777002541	Phosphoglycerate kinase; Region: PGK; pfam00162
866777002542	substrate binding site [chemical binding]; other site
866777002543	hinge regions; other site
866777002544	ADP binding site [chemical binding]; other site
866777002545	catalytic site [active]
866777002546	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
866777002547	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
866777002548	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
866777002549	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
866777002550	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
866777002551	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
866777002552	shikimate binding site; other site
866777002553	NAD(P) binding site [chemical binding]; other site
866777002554	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
866777002555	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
866777002556	GIY-YIG motif/motif A; other site
866777002557	active site
866777002558	catalytic site [active]
866777002559	putative DNA binding site [nucleotide binding]; other site
866777002560	metal binding site [ion binding]; metal-binding site
866777002561	UvrB/uvrC motif; Region: UVR; pfam02151
866777002562	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
866777002563	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
866777002564	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
866777002565	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866777002566	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866777002567	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
866777002568	aspartate aminotransferase; Provisional; Region: PRK06836
866777002569	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777002570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777002571	homodimer interface [polypeptide binding]; other site
866777002572	catalytic residue [active]
866777002573	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
866777002574	classical (c) SDRs; Region: SDR_c; cd05233
866777002575	NAD(P) binding site [chemical binding]; other site
866777002576	active site
866777002577	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866777002578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777002579	Walker A/P-loop; other site
866777002580	ATP binding site [chemical binding]; other site
866777002581	Q-loop/lid; other site
866777002582	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866777002583	ABC transporter signature motif; other site
866777002584	Walker B; other site
866777002585	D-loop; other site
866777002586	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866777002587	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
866777002588	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
866777002589	putative substrate binding site [chemical binding]; other site
866777002590	putative ATP binding site [chemical binding]; other site
866777002591	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
866777002592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777002593	motif II; other site
866777002594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866777002595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866777002596	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866777002597	dimerization interface [polypeptide binding]; other site
866777002598	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
866777002599	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777002600	active site
866777002601	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
866777002602	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
866777002603	heterodimer interface [polypeptide binding]; other site
866777002604	active site
866777002605	FMN binding site [chemical binding]; other site
866777002606	homodimer interface [polypeptide binding]; other site
866777002607	substrate binding site [chemical binding]; other site
866777002608	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
866777002609	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
866777002610	FAD binding pocket [chemical binding]; other site
866777002611	FAD binding motif [chemical binding]; other site
866777002612	phosphate binding motif [ion binding]; other site
866777002613	beta-alpha-beta structure motif; other site
866777002614	NAD binding pocket [chemical binding]; other site
866777002615	Iron coordination center [ion binding]; other site
866777002616	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
866777002617	active site
866777002618	dimer interface [polypeptide binding]; other site
866777002619	dihydroorotase; Validated; Region: pyrC; PRK09357
866777002620	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
866777002621	active site
866777002622	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
866777002623	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
866777002624	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
866777002625	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
866777002626	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866777002627	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866777002628	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
866777002629	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866777002630	metal binding triad; other site
866777002631	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
866777002632	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866777002633	metal binding triad; other site
866777002634	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
866777002635	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
866777002636	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
866777002637	active site
866777002638	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
866777002639	FAD binding site [chemical binding]; other site
866777002640	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
866777002641	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
866777002642	THF binding site; other site
866777002643	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
866777002644	substrate binding site [chemical binding]; other site
866777002645	THF binding site; other site
866777002646	zinc-binding site [ion binding]; other site
866777002647	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777002648	catalytic core [active]
866777002649	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
866777002650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777002651	S-adenosylmethionine binding site [chemical binding]; other site
866777002652	Predicted esterase [General function prediction only]; Region: COG0400
866777002653	putative hydrolase; Provisional; Region: PRK11460
866777002654	Putative transcription activator [Transcription]; Region: TenA; COG0819
866777002655	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
866777002656	putative active site [active]
866777002657	putative metal binding site [ion binding]; other site
866777002658	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
866777002659	putative ADP-ribose binding site [chemical binding]; other site
866777002660	putative active site [active]
866777002661	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
866777002662	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866777002663	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
866777002664	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
866777002665	Predicted permeases [General function prediction only]; Region: RarD; COG2962
866777002666	YfbU domain; Region: YfbU; cl01137
866777002667	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
866777002668	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777002669	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866777002670	active site
866777002671	motif I; other site
866777002672	motif II; other site
866777002673	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
866777002674	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866777002675	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866777002676	Walker A/P-loop; other site
866777002677	ATP binding site [chemical binding]; other site
866777002678	Q-loop/lid; other site
866777002679	ABC transporter signature motif; other site
866777002680	Walker B; other site
866777002681	D-loop; other site
866777002682	H-loop/switch region; other site
866777002683	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
866777002684	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
866777002685	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866777002686	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
866777002687	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
866777002688	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866777002689	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
866777002690	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
866777002691	active site
866777002692	dimer interface [polypeptide binding]; other site
866777002693	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
866777002694	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
866777002695	active site
866777002696	FMN binding site [chemical binding]; other site
866777002697	substrate binding site [chemical binding]; other site
866777002698	3Fe-4S cluster binding site [ion binding]; other site
866777002699	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
866777002700	domain interface; other site
866777002701	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777002702	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777002703	ligand binding site [chemical binding]; other site
866777002704	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777002705	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777002706	DNA binding site [nucleotide binding]
866777002707	domain linker motif; other site
866777002708	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
866777002709	ligand binding site [chemical binding]; other site
866777002710	dimerization interface (open form) [polypeptide binding]; other site
866777002711	dimerization interface (closed form) [polypeptide binding]; other site
866777002712	coproporphyrinogen III oxidase; Validated; Region: PRK05628
866777002713	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866777002714	FeS/SAM binding site; other site
866777002715	HemN C-terminal domain; Region: HemN_C; pfam06969
866777002716	GTP-binding protein LepA; Provisional; Region: PRK05433
866777002717	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
866777002718	G1 box; other site
866777002719	putative GEF interaction site [polypeptide binding]; other site
866777002720	GTP/Mg2+ binding site [chemical binding]; other site
866777002721	Switch I region; other site
866777002722	G2 box; other site
866777002723	G3 box; other site
866777002724	Switch II region; other site
866777002725	G4 box; other site
866777002726	G5 box; other site
866777002727	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
866777002728	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
866777002729	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
866777002730	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
866777002731	UPF0126 domain; Region: UPF0126; pfam03458
866777002732	Predicted membrane protein [Function unknown]; Region: COG2860
866777002733	UPF0126 domain; Region: UPF0126; pfam03458
866777002734	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
866777002735	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
866777002736	homodimer interface [polypeptide binding]; other site
866777002737	substrate-cofactor binding pocket; other site
866777002738	catalytic residue [active]
866777002739	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
866777002740	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
866777002741	5S rRNA interface [nucleotide binding]; other site
866777002742	CTC domain interface [polypeptide binding]; other site
866777002743	L16 interface [polypeptide binding]; other site
866777002744	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
866777002745	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
866777002746	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
866777002747	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
866777002748	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
866777002749	ligand binding site [chemical binding]; other site
866777002750	homodimer interface [polypeptide binding]; other site
866777002751	NAD(P) binding site [chemical binding]; other site
866777002752	trimer interface B [polypeptide binding]; other site
866777002753	trimer interface A [polypeptide binding]; other site
866777002754	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
866777002755	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
866777002756	acyl-activating enzyme (AAE) consensus motif; other site
866777002757	putative AMP binding site [chemical binding]; other site
866777002758	putative active site [active]
866777002759	putative CoA binding site [chemical binding]; other site
866777002760	Domain of unknown function DUF21; Region: DUF21; pfam01595
866777002761	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866777002762	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866777002763	Transporter associated domain; Region: CorC_HlyC; smart01091
866777002764	GTPase Era; Reviewed; Region: era; PRK00089
866777002765	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
866777002766	G1 box; other site
866777002767	GTP/Mg2+ binding site [chemical binding]; other site
866777002768	Switch I region; other site
866777002769	G2 box; other site
866777002770	Switch II region; other site
866777002771	G3 box; other site
866777002772	G4 box; other site
866777002773	G5 box; other site
866777002774	KH domain; Region: KH_2; pfam07650
866777002775	metal-binding heat shock protein; Provisional; Region: PRK00016
866777002776	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
866777002777	PhoH-like protein; Region: PhoH; pfam02562
866777002778	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
866777002779	nucleotide binding site/active site [active]
866777002780	HIT family signature motif; other site
866777002781	catalytic residue [active]
866777002782	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
866777002783	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
866777002784	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
866777002785	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866777002786	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
866777002787	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
866777002788	ligand binding site; other site
866777002789	oligomer interface; other site
866777002790	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
866777002791	dimer interface [polypeptide binding]; other site
866777002792	N-terminal domain interface [polypeptide binding]; other site
866777002793	sulfate 1 binding site; other site
866777002794	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
866777002795	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
866777002796	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
866777002797	trimerization site [polypeptide binding]; other site
866777002798	active site
866777002799	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
866777002800	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
866777002801	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866777002802	catalytic residue [active]
866777002803	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
866777002804	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
866777002805	Walker A/P-loop; other site
866777002806	ATP binding site [chemical binding]; other site
866777002807	Q-loop/lid; other site
866777002808	ABC transporter signature motif; other site
866777002809	Walker B; other site
866777002810	D-loop; other site
866777002811	H-loop/switch region; other site
866777002812	FeS assembly protein SufD; Region: sufD; TIGR01981
866777002813	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
866777002814	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
866777002815	FeS assembly protein SufB; Region: sufB; TIGR01980
866777002816	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866777002817	CTP synthetase; Validated; Region: pyrG; PRK05380
866777002818	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
866777002819	Catalytic site [active]
866777002820	active site
866777002821	UTP binding site [chemical binding]; other site
866777002822	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
866777002823	active site
866777002824	putative oxyanion hole; other site
866777002825	catalytic triad [active]
866777002826	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
866777002827	Dehydroquinase class II; Region: DHquinase_II; pfam01220
866777002828	trimer interface [polypeptide binding]; other site
866777002829	active site
866777002830	dimer interface [polypeptide binding]; other site
866777002831	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
866777002832	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
866777002833	ADP binding site [chemical binding]; other site
866777002834	magnesium binding site [ion binding]; other site
866777002835	putative shikimate binding site; other site
866777002836	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
866777002837	active site
866777002838	dimer interface [polypeptide binding]; other site
866777002839	metal binding site [ion binding]; metal-binding site
866777002840	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
866777002841	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
866777002842	Tetramer interface [polypeptide binding]; other site
866777002843	active site
866777002844	FMN-binding site [chemical binding]; other site
866777002845	YceG-like family; Region: YceG; pfam02618
866777002846	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
866777002847	dimerization interface [polypeptide binding]; other site
866777002848	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
866777002849	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
866777002850	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
866777002851	motif 1; other site
866777002852	active site
866777002853	motif 2; other site
866777002854	motif 3; other site
866777002855	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866777002856	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
866777002857	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777002858	catalytic core [active]
866777002859	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
866777002860	RelB antitoxin; Region: RelB; cl01171
866777002861	PemK-like protein; Region: PemK; pfam02452
866777002862	SdpI/YhfL protein family; Region: SdpI; pfam13630
866777002863	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
866777002864	active site
866777002865	catalytic motif [active]
866777002866	Zn binding site [ion binding]; other site
866777002867	Peptidase C26; Region: Peptidase_C26; pfam07722
866777002868	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
866777002869	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
866777002870	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
866777002871	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
866777002872	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866777002873	RNA binding surface [nucleotide binding]; other site
866777002874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777002875	AAA domain; Region: AAA_21; pfam13304
866777002876	Walker A/P-loop; other site
866777002877	ATP binding site [chemical binding]; other site
866777002878	Q-loop/lid; other site
866777002879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777002880	ABC transporter signature motif; other site
866777002881	Walker B; other site
866777002882	D-loop; other site
866777002883	H-loop/switch region; other site
866777002884	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777002885	FtsX-like permease family; Region: FtsX; pfam02687
866777002886	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
866777002887	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
866777002888	Part of AAA domain; Region: AAA_19; pfam13245
866777002889	Family description; Region: UvrD_C_2; pfam13538
866777002890	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777002891	active site
866777002892	xanthine permease; Region: pbuX; TIGR03173
866777002893	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866777002894	salt bridge; other site
866777002895	non-specific DNA binding site [nucleotide binding]; other site
866777002896	sequence-specific DNA binding site [nucleotide binding]; other site
866777002897	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
866777002898	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866777002899	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
866777002900	Isochorismatase family; Region: Isochorismatase; pfam00857
866777002901	catalytic triad [active]
866777002902	metal binding site [ion binding]; metal-binding site
866777002903	conserved cis-peptide bond; other site
866777002904	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
866777002905	conserved cys residue [active]
866777002906	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
866777002907	DNA binding residues [nucleotide binding]
866777002908	PIN domain; Region: PIN_3; pfam13470
866777002909	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
866777002910	Divergent AAA domain; Region: AAA_4; pfam04326
866777002911	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
866777002912	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866777002913	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
866777002914	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866777002915	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866777002916	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777002917	Walker A/P-loop; other site
866777002918	ATP binding site [chemical binding]; other site
866777002919	Q-loop/lid; other site
866777002920	ABC transporter signature motif; other site
866777002921	Walker B; other site
866777002922	D-loop; other site
866777002923	H-loop/switch region; other site
866777002924	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
866777002925	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
866777002926	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866777002927	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866777002928	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866777002929	Histidine kinase; Region: HisKA_3; pfam07730
866777002930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777002931	ATP binding site [chemical binding]; other site
866777002932	Mg2+ binding site [ion binding]; other site
866777002933	G-X-G motif; other site
866777002934	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777002935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777002936	active site
866777002937	phosphorylation site [posttranslational modification]
866777002938	intermolecular recognition site; other site
866777002939	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777002940	DNA binding residues [nucleotide binding]
866777002941	dimerization interface [polypeptide binding]; other site
866777002942	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
866777002943	Phosphate transporter family; Region: PHO4; pfam01384
866777002944	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
866777002945	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866777002946	active site
866777002947	catalytic site [active]
866777002948	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866777002949	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866777002950	ATP binding site [chemical binding]; other site
866777002951	Mg++ binding site [ion binding]; other site
866777002952	motif III; other site
866777002953	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777002954	nucleotide binding region [chemical binding]; other site
866777002955	ATP-binding site [chemical binding]; other site
866777002956	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
866777002957	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777002958	catalytic core [active]
866777002959	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866777002960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777002961	H+ Antiporter protein; Region: 2A0121; TIGR00900
866777002962	putative substrate translocation pore; other site
866777002963	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866777002964	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
866777002965	active site
866777002966	trimer interface [polypeptide binding]; other site
866777002967	allosteric site; other site
866777002968	active site lid [active]
866777002969	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866777002970	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
866777002971	Amidohydrolase; Region: Amidohydro_4; pfam13147
866777002972	active site
866777002973	dimer interface [polypeptide binding]; other site
866777002974	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866777002975	putative transporter; Provisional; Region: PRK10504
866777002976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777002977	putative substrate translocation pore; other site
866777002978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777002979	putative substrate translocation pore; other site
866777002980	FOG: CBS domain [General function prediction only]; Region: COG0517
866777002981	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
866777002982	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777002983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777002984	H+ Antiporter protein; Region: 2A0121; TIGR00900
866777002985	HipA-like C-terminal domain; Region: HipA_C; pfam07804
866777002986	RelB antitoxin; Region: RelB; cl01171
866777002987	PemK-like protein; Region: PemK; pfam02452
866777002988	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
866777002989	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866777002990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777002991	S-adenosylmethionine binding site [chemical binding]; other site
866777002992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866777002993	hypothetical protein; Provisional; Region: PRK11770
866777002994	Domain of unknown function (DUF307); Region: DUF307; pfam03733
866777002995	Domain of unknown function (DUF307); Region: DUF307; pfam03733
866777002996	Fic family protein [Function unknown]; Region: COG3177
866777002997	Fic/DOC family; Region: Fic; pfam02661
866777002998	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777002999	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
866777003000	Walker A/P-loop; other site
866777003001	ATP binding site [chemical binding]; other site
866777003002	Q-loop/lid; other site
866777003003	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866777003004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003005	Walker A/P-loop; other site
866777003006	ATP binding site [chemical binding]; other site
866777003007	Q-loop/lid; other site
866777003008	ABC transporter signature motif; other site
866777003009	Walker B; other site
866777003010	D-loop; other site
866777003011	H-loop/switch region; other site
866777003012	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
866777003013	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
866777003014	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866777003015	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866777003016	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
866777003017	GTP-binding protein YchF; Reviewed; Region: PRK09601
866777003018	YchF GTPase; Region: YchF; cd01900
866777003019	G1 box; other site
866777003020	GTP/Mg2+ binding site [chemical binding]; other site
866777003021	Switch I region; other site
866777003022	G2 box; other site
866777003023	Switch II region; other site
866777003024	G3 box; other site
866777003025	G4 box; other site
866777003026	G5 box; other site
866777003027	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
866777003028	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866777003029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777003030	dimer interface [polypeptide binding]; other site
866777003031	conserved gate region; other site
866777003032	putative PBP binding loops; other site
866777003033	ABC-ATPase subunit interface; other site
866777003034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777003035	dimer interface [polypeptide binding]; other site
866777003036	conserved gate region; other site
866777003037	ABC-ATPase subunit interface; other site
866777003038	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866777003039	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866777003040	Walker A/P-loop; other site
866777003041	ATP binding site [chemical binding]; other site
866777003042	Q-loop/lid; other site
866777003043	ABC transporter signature motif; other site
866777003044	Walker B; other site
866777003045	D-loop; other site
866777003046	H-loop/switch region; other site
866777003047	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
866777003048	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866777003049	substrate binding pocket [chemical binding]; other site
866777003050	membrane-bound complex binding site; other site
866777003051	hinge residues; other site
866777003052	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
866777003053	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
866777003054	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866777003055	Histidine kinase; Region: HisKA_3; pfam07730
866777003056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777003057	ATP binding site [chemical binding]; other site
866777003058	Mg2+ binding site [ion binding]; other site
866777003059	G-X-G motif; other site
866777003060	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777003061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777003062	active site
866777003063	phosphorylation site [posttranslational modification]
866777003064	intermolecular recognition site; other site
866777003065	dimerization interface [polypeptide binding]; other site
866777003066	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777003067	DNA binding residues [nucleotide binding]
866777003068	dimerization interface [polypeptide binding]; other site
866777003069	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866777003070	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777003071	FtsX-like permease family; Region: FtsX; pfam02687
866777003072	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777003073	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777003074	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777003075	Walker A/P-loop; other site
866777003076	ATP binding site [chemical binding]; other site
866777003077	Q-loop/lid; other site
866777003078	ABC transporter signature motif; other site
866777003079	Walker B; other site
866777003080	D-loop; other site
866777003081	H-loop/switch region; other site
866777003082	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
866777003083	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866777003084	homodimer interface [polypeptide binding]; other site
866777003085	substrate-cofactor binding pocket; other site
866777003086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003087	catalytic residue [active]
866777003088	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
866777003089	dimer interface [polypeptide binding]; other site
866777003090	pyridoxal binding site [chemical binding]; other site
866777003091	ATP binding site [chemical binding]; other site
866777003092	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
866777003093	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
866777003094	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
866777003095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777003096	Walker A motif; other site
866777003097	ATP binding site [chemical binding]; other site
866777003098	Walker B motif; other site
866777003099	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
866777003100	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
866777003101	DNA protecting protein DprA; Region: dprA; TIGR00732
866777003102	L-aspartate oxidase; Provisional; Region: PRK06175
866777003103	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
866777003104	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866777003105	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
866777003106	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
866777003107	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
866777003108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866777003109	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
866777003110	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
866777003111	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
866777003112	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777003113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003114	homodimer interface [polypeptide binding]; other site
866777003115	catalytic residue [active]
866777003116	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
866777003117	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
866777003118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777003119	Walker A motif; other site
866777003120	ATP binding site [chemical binding]; other site
866777003121	Walker B motif; other site
866777003122	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866777003123	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
866777003124	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
866777003125	oligomer interface [polypeptide binding]; other site
866777003126	active site residues [active]
866777003127	Clp protease; Region: CLP_protease; pfam00574
866777003128	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
866777003129	oligomer interface [polypeptide binding]; other site
866777003130	active site residues [active]
866777003131	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
866777003132	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
866777003133	putative ion selectivity filter; other site
866777003134	putative pore gating glutamate residue; other site
866777003135	trigger factor; Provisional; Region: tig; PRK01490
866777003136	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866777003137	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
866777003138	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
866777003139	active site
866777003140	substrate binding site [chemical binding]; other site
866777003141	catalytic site [active]
866777003142	HRDC domain; Region: HRDC; pfam00570
866777003143	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
866777003144	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
866777003145	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866777003146	FeS/SAM binding site; other site
866777003147	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
866777003148	Pyruvate formate lyase 1; Region: PFL1; cd01678
866777003149	coenzyme A binding site [chemical binding]; other site
866777003150	active site
866777003151	catalytic residues [active]
866777003152	glycine loop; other site
866777003153	NAD synthetase; Provisional; Region: PRK13981
866777003154	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
866777003155	multimer interface [polypeptide binding]; other site
866777003156	active site
866777003157	catalytic triad [active]
866777003158	protein interface 1 [polypeptide binding]; other site
866777003159	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
866777003160	homodimer interface [polypeptide binding]; other site
866777003161	NAD binding pocket [chemical binding]; other site
866777003162	ATP binding pocket [chemical binding]; other site
866777003163	Mg binding site [ion binding]; other site
866777003164	active-site loop [active]
866777003165	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866777003166	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866777003167	metal binding site [ion binding]; metal-binding site
866777003168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866777003169	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
866777003170	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866777003171	Walker A/P-loop; other site
866777003172	ATP binding site [chemical binding]; other site
866777003173	Q-loop/lid; other site
866777003174	ABC transporter signature motif; other site
866777003175	Walker B; other site
866777003176	D-loop; other site
866777003177	H-loop/switch region; other site
866777003178	NIL domain; Region: NIL; pfam09383
866777003179	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866777003180	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866777003181	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
866777003182	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777003183	active site
866777003184	motif I; other site
866777003185	motif II; other site
866777003186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777003187	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777003188	catalytic core [active]
866777003189	Oligomerisation domain; Region: Oligomerisation; pfam02410
866777003190	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
866777003191	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
866777003192	Substrate binding site; other site
866777003193	Mg++ binding site; other site
866777003194	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
866777003195	active site
866777003196	substrate binding site [chemical binding]; other site
866777003197	CoA binding site [chemical binding]; other site
866777003198	putative phosphoketolase; Provisional; Region: PRK05261
866777003199	XFP N-terminal domain; Region: XFP_N; pfam09364
866777003200	XFP C-terminal domain; Region: XFP_C; pfam09363
866777003201	GMP synthase; Reviewed; Region: guaA; PRK00074
866777003202	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
866777003203	AMP/PPi binding site [chemical binding]; other site
866777003204	candidate oxyanion hole; other site
866777003205	catalytic triad [active]
866777003206	potential glutamine specificity residues [chemical binding]; other site
866777003207	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
866777003208	ATP Binding subdomain [chemical binding]; other site
866777003209	Ligand Binding sites [chemical binding]; other site
866777003210	Dimerization subdomain; other site
866777003211	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
866777003212	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
866777003213	catalytic triad [active]
866777003214	catalytic triad [active]
866777003215	oxyanion hole [active]
866777003216	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
866777003217	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
866777003218	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777003219	active site
866777003220	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
866777003221	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
866777003222	propionate/acetate kinase; Provisional; Region: PRK12379
866777003223	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
866777003224	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
866777003225	hinge; other site
866777003226	active site
866777003227	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
866777003228	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
866777003229	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
866777003230	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
866777003231	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
866777003232	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
866777003233	active site
866777003234	catalytic site [active]
866777003235	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
866777003236	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866777003237	dimer interface [polypeptide binding]; other site
866777003238	ADP-ribose binding site [chemical binding]; other site
866777003239	active site
866777003240	nudix motif; other site
866777003241	metal binding site [ion binding]; metal-binding site
866777003242	Uncharacterized conserved protein [Function unknown]; Region: COG0327
866777003243	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
866777003244	DNA polymerase I; Provisional; Region: PRK05755
866777003245	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
866777003246	active site
866777003247	metal binding site 1 [ion binding]; metal-binding site
866777003248	putative 5' ssDNA interaction site; other site
866777003249	metal binding site 3; metal-binding site
866777003250	metal binding site 2 [ion binding]; metal-binding site
866777003251	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
866777003252	putative DNA binding site [nucleotide binding]; other site
866777003253	putative metal binding site [ion binding]; other site
866777003254	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
866777003255	active site
866777003256	substrate binding site [chemical binding]; other site
866777003257	catalytic site [active]
866777003258	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
866777003259	active site
866777003260	DNA binding site [nucleotide binding]
866777003261	catalytic site [active]
866777003262	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
866777003263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777003264	active site
866777003265	phosphorylation site [posttranslational modification]
866777003266	intermolecular recognition site; other site
866777003267	dimerization interface [polypeptide binding]; other site
866777003268	ANTAR domain; Region: ANTAR; pfam03861
866777003269	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
866777003270	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866777003271	dimer interface [polypeptide binding]; other site
866777003272	ADP-ribose binding site [chemical binding]; other site
866777003273	active site
866777003274	nudix motif; other site
866777003275	metal binding site [ion binding]; metal-binding site
866777003276	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
866777003277	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
866777003278	domain interfaces; other site
866777003279	active site
866777003280	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
866777003281	excinuclease ABC subunit B; Provisional; Region: PRK05298
866777003282	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777003283	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777003284	nucleotide binding region [chemical binding]; other site
866777003285	ATP-binding site [chemical binding]; other site
866777003286	Ultra-violet resistance protein B; Region: UvrB; pfam12344
866777003287	UvrB/uvrC motif; Region: UVR; pfam02151
866777003288	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
866777003289	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
866777003290	CoA-binding site [chemical binding]; other site
866777003291	ATP-binding [chemical binding]; other site
866777003292	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
866777003293	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
866777003294	RNA binding site [nucleotide binding]; other site
866777003295	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
866777003296	RNA binding site [nucleotide binding]; other site
866777003297	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
866777003298	RNA binding site [nucleotide binding]; other site
866777003299	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
866777003300	RNA binding site [nucleotide binding]; other site
866777003301	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
866777003302	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
866777003303	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
866777003304	homodimer interface [polypeptide binding]; other site
866777003305	NADP binding site [chemical binding]; other site
866777003306	substrate binding site [chemical binding]; other site
866777003307	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
866777003308	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
866777003309	metal binding site [ion binding]; metal-binding site
866777003310	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
866777003311	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
866777003312	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
866777003313	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866777003314	ABC-ATPase subunit  interface; other site
866777003315	dimer interface [polypeptide binding]; other site
866777003316	putative PBP binding regions; other site
866777003317	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084
866777003318	homotrimer interaction site [polypeptide binding]; other site
866777003319	zinc binding site [ion binding]; other site
866777003320	CDP-binding sites; other site
866777003321	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
866777003322	glycogen branching enzyme; Provisional; Region: PRK05402
866777003323	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
866777003324	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
866777003325	active site
866777003326	catalytic site [active]
866777003327	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
866777003328	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866777003329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777003330	active site
866777003331	phosphorylation site [posttranslational modification]
866777003332	intermolecular recognition site; other site
866777003333	dimerization interface [polypeptide binding]; other site
866777003334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866777003335	DNA binding site [nucleotide binding]
866777003336	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
866777003337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866777003338	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866777003339	dimerization interface [polypeptide binding]; other site
866777003340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866777003341	dimer interface [polypeptide binding]; other site
866777003342	phosphorylation site [posttranslational modification]
866777003343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777003344	ATP binding site [chemical binding]; other site
866777003345	Mg2+ binding site [ion binding]; other site
866777003346	G-X-G motif; other site
866777003347	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777003348	active site
866777003349	Eukaryotic phosphomannomutase; Region: PMM; cl17107
866777003350	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
866777003351	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
866777003352	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866777003353	Transcription factor WhiB; Region: Whib; pfam02467
866777003354	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866777003355	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
866777003356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003357	Walker A/P-loop; other site
866777003358	ATP binding site [chemical binding]; other site
866777003359	Transcription factor WhiB; Region: Whib; pfam02467
866777003360	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
866777003361	PAS fold; Region: PAS_4; pfam08448
866777003362	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
866777003363	Histidine kinase; Region: HisKA_2; pfam07568
866777003364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777003365	ATP binding site [chemical binding]; other site
866777003366	Mg2+ binding site [ion binding]; other site
866777003367	G-X-G motif; other site
866777003368	Haemolysin-III related; Region: HlyIII; pfam03006
866777003369	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
866777003370	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
866777003371	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
866777003372	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
866777003373	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866777003374	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
866777003375	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
866777003376	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
866777003377	exopolyphosphatase; Region: exo_poly_only; TIGR03706
866777003378	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
866777003379	Protein of unknown function (DUF501); Region: DUF501; pfam04417
866777003380	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
866777003381	Septum formation initiator; Region: DivIC; pfam04977
866777003382	enolase; Provisional; Region: eno; PRK00077
866777003383	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
866777003384	dimer interface [polypeptide binding]; other site
866777003385	metal binding site [ion binding]; metal-binding site
866777003386	substrate binding pocket [chemical binding]; other site
866777003387	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777003388	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777003389	active site
866777003390	catalytic tetrad [active]
866777003391	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
866777003392	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
866777003393	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777003394	ATP binding site [chemical binding]; other site
866777003395	putative Mg++ binding site [ion binding]; other site
866777003396	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777003397	nucleotide binding region [chemical binding]; other site
866777003398	ATP-binding site [chemical binding]; other site
866777003399	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
866777003400	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
866777003401	putative active site [active]
866777003402	catalytic residue [active]
866777003403	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866777003404	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866777003405	Coenzyme A binding pocket [chemical binding]; other site
866777003406	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
866777003407	Uncharacterized conserved protein [Function unknown]; Region: COG1615
866777003408	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866777003409	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
866777003410	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
866777003411	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
866777003412	active site
866777003413	(T/H)XGH motif; other site
866777003414	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
866777003415	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
866777003416	putative catalytic cysteine [active]
866777003417	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
866777003418	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
866777003419	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003420	catalytic residue [active]
866777003421	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
866777003422	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
866777003423	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866777003424	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866777003425	Walker A/P-loop; other site
866777003426	ATP binding site [chemical binding]; other site
866777003427	Q-loop/lid; other site
866777003428	ABC transporter signature motif; other site
866777003429	Walker B; other site
866777003430	D-loop; other site
866777003431	H-loop/switch region; other site
866777003432	Predicted transcriptional regulators [Transcription]; Region: COG1725
866777003433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866777003434	DNA-binding site [nucleotide binding]; DNA binding site
866777003435	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866777003436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866777003437	Coenzyme A binding pocket [chemical binding]; other site
866777003438	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
866777003439	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777003440	motif II; other site
866777003441	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
866777003442	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866777003443	Walker A/P-loop; other site
866777003444	ATP binding site [chemical binding]; other site
866777003445	Q-loop/lid; other site
866777003446	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866777003447	ABC transporter signature motif; other site
866777003448	Walker B; other site
866777003449	D-loop; other site
866777003450	H-loop/switch region; other site
866777003451	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
866777003452	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
866777003453	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
866777003454	TrkA-C domain; Region: TrkA_C; pfam02080
866777003455	Protein of unknown function (DUF342); Region: DUF342; pfam03961
866777003456	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
866777003457	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866777003458	RNA binding surface [nucleotide binding]; other site
866777003459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777003460	S-adenosylmethionine binding site [chemical binding]; other site
866777003461	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
866777003462	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777003463	active site
866777003464	motif I; other site
866777003465	motif II; other site
866777003466	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777003467	motif II; other site
866777003468	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
866777003469	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
866777003470	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
866777003471	active site
866777003472	HIGH motif; other site
866777003473	dimer interface [polypeptide binding]; other site
866777003474	KMSKS motif; other site
866777003475	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866777003476	RNA binding surface [nucleotide binding]; other site
866777003477	Protein of unknown function (DUF975); Region: DUF975; cl10504
866777003478	Predicted membrane protein [Function unknown]; Region: COG4905
866777003479	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
866777003480	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866777003481	Zn2+ binding site [ion binding]; other site
866777003482	Mg2+ binding site [ion binding]; other site
866777003483	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866777003484	active site residue [active]
866777003485	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
866777003486	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
866777003487	ATP binding site [chemical binding]; other site
866777003488	substrate interface [chemical binding]; other site
866777003489	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
866777003490	ThiS interaction site; other site
866777003491	putative active site [active]
866777003492	tetramer interface [polypeptide binding]; other site
866777003493	argininosuccinate lyase; Provisional; Region: PRK00855
866777003494	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
866777003495	active sites [active]
866777003496	tetramer interface [polypeptide binding]; other site
866777003497	RelB antitoxin; Region: RelB; cl01171
866777003498	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
866777003499	transposase/IS protein; Provisional; Region: PRK09183
866777003500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777003501	Walker A motif; other site
866777003502	ATP binding site [chemical binding]; other site
866777003503	Walker B motif; other site
866777003504	argininosuccinate synthase; Provisional; Region: PRK13820
866777003505	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
866777003506	ANP binding site [chemical binding]; other site
866777003507	Substrate Binding Site II [chemical binding]; other site
866777003508	Substrate Binding Site I [chemical binding]; other site
866777003509	arginine repressor; Provisional; Region: PRK03341
866777003510	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
866777003511	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
866777003512	ornithine carbamoyltransferase; Provisional; Region: PRK00779
866777003513	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866777003514	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866777003515	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
866777003516	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866777003517	inhibitor-cofactor binding pocket; inhibition site
866777003518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003519	catalytic residue [active]
866777003520	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
866777003521	feedback inhibition sensing region; other site
866777003522	homohexameric interface [polypeptide binding]; other site
866777003523	nucleotide binding site [chemical binding]; other site
866777003524	N-acetyl-L-glutamate binding site [chemical binding]; other site
866777003525	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
866777003526	heterotetramer interface [polypeptide binding]; other site
866777003527	active site pocket [active]
866777003528	cleavage site
866777003529	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
866777003530	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866777003531	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
866777003532	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
866777003533	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
866777003534	putative tRNA-binding site [nucleotide binding]; other site
866777003535	B3/4 domain; Region: B3_4; pfam03483
866777003536	tRNA synthetase B5 domain; Region: B5; pfam03484
866777003537	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
866777003538	dimer interface [polypeptide binding]; other site
866777003539	motif 1; other site
866777003540	motif 3; other site
866777003541	motif 2; other site
866777003542	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
866777003543	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
866777003544	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
866777003545	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
866777003546	dimer interface [polypeptide binding]; other site
866777003547	motif 1; other site
866777003548	active site
866777003549	motif 2; other site
866777003550	motif 3; other site
866777003551	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
866777003552	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
866777003553	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866777003554	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866777003555	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866777003556	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
866777003557	Walker A/P-loop; other site
866777003558	ATP binding site [chemical binding]; other site
866777003559	Q-loop/lid; other site
866777003560	ABC transporter signature motif; other site
866777003561	Walker B; other site
866777003562	D-loop; other site
866777003563	H-loop/switch region; other site
866777003564	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866777003565	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866777003566	Walker A/P-loop; other site
866777003567	ATP binding site [chemical binding]; other site
866777003568	Q-loop/lid; other site
866777003569	ABC transporter signature motif; other site
866777003570	Walker B; other site
866777003571	D-loop; other site
866777003572	H-loop/switch region; other site
866777003573	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
866777003574	hypothetical protein; Provisional; Region: PRK07907
866777003575	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
866777003576	active site
866777003577	metal binding site [ion binding]; metal-binding site
866777003578	dimer interface [polypeptide binding]; other site
866777003579	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
866777003580	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
866777003581	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866777003582	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866777003583	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866777003584	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
866777003585	glutamine synthetase, type I; Region: GlnA; TIGR00653
866777003586	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
866777003587	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
866777003588	Domain of unknown function DUF59; Region: DUF59; cl00941
866777003589	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
866777003590	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
866777003591	Walker A motif; other site
866777003592	Ligase N family; Region: LIGANc; smart00532
866777003593	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
866777003594	nucleotide binding pocket [chemical binding]; other site
866777003595	K-X-D-G motif; other site
866777003596	catalytic site [active]
866777003597	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
866777003598	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
866777003599	Helix-hairpin-helix motif; Region: HHH; pfam00633
866777003600	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
866777003601	Dimer interface [polypeptide binding]; other site
866777003602	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866777003603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003604	Walker A/P-loop; other site
866777003605	ATP binding site [chemical binding]; other site
866777003606	ABC transporter signature motif; other site
866777003607	Walker B; other site
866777003608	D-loop; other site
866777003609	H-loop/switch region; other site
866777003610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777003611	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
866777003612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003613	homodimer interface [polypeptide binding]; other site
866777003614	catalytic residue [active]
866777003615	NMT1/THI5 like; Region: NMT1; pfam09084
866777003616	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
866777003617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777003618	dimer interface [polypeptide binding]; other site
866777003619	conserved gate region; other site
866777003620	putative PBP binding loops; other site
866777003621	ABC-ATPase subunit interface; other site
866777003622	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829
866777003623	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
866777003624	catalytic residue [active]
866777003625	putative FPP diphosphate  binding site; other site
866777003626	putative FPP binding hydrophobic cleft; other site
866777003627	dimer interface [polypeptide binding]; other site
866777003628	putative IPP diphosphate binding site; other site
866777003629	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
866777003630	Recombination protein O N terminal; Region: RecO_N; pfam11967
866777003631	Recombination protein O C terminal; Region: RecO_C; pfam02565
866777003632	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866777003633	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
866777003634	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
866777003635	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
866777003636	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
866777003637	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
866777003638	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
866777003639	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
866777003640	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
866777003641	DivIVA domain; Region: DivI1A_domain; TIGR03544
866777003642	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
866777003643	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
866777003644	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
866777003645	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
866777003646	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
866777003647	Part of AAA domain; Region: AAA_19; pfam13245
866777003648	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
866777003649	Family description; Region: UvrD_C_2; pfam13538
866777003650	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
866777003651	substrate binding site [chemical binding]; other site
866777003652	Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
866777003653	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
866777003654	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
866777003655	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
866777003656	active site
866777003657	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
866777003658	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
866777003659	putative active site [active]
866777003660	redox center [active]
866777003661	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
866777003662	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
866777003663	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
866777003664	glutamate racemase; Provisional; Region: PRK00865
866777003665	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
866777003666	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
866777003667	active site
866777003668	nucleophile elbow; other site
866777003669	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
866777003670	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
866777003671	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866777003672	AAA domain; Region: AAA_14; pfam13173
866777003673	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
866777003674	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
866777003675	catalytic residues [active]
866777003676	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
866777003677	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866777003678	homodimer interface [polypeptide binding]; other site
866777003679	substrate-cofactor binding pocket; other site
866777003680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003681	catalytic residue [active]
866777003682	Predicted esterase [General function prediction only]; Region: COG0400
866777003683	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
866777003684	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
866777003685	G1 box; other site
866777003686	putative GEF interaction site [polypeptide binding]; other site
866777003687	GTP/Mg2+ binding site [chemical binding]; other site
866777003688	Switch I region; other site
866777003689	G2 box; other site
866777003690	G3 box; other site
866777003691	Switch II region; other site
866777003692	G4 box; other site
866777003693	G5 box; other site
866777003694	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
866777003695	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
866777003696	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
866777003697	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866777003698	active site
866777003699	catalytic site [active]
866777003700	substrate binding site [chemical binding]; other site
866777003701	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
866777003702	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
866777003703	catalytic site [active]
866777003704	G-X2-G-X-G-K; other site
866777003705	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
866777003706	active site
866777003707	dimer interface [polypeptide binding]; other site
866777003708	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
866777003709	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866777003710	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866777003711	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
866777003712	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866777003713	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866777003714	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
866777003715	IMP binding site; other site
866777003716	dimer interface [polypeptide binding]; other site
866777003717	interdomain contacts; other site
866777003718	partial ornithine binding site; other site
866777003719	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
866777003720	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
866777003721	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
866777003722	catalytic site [active]
866777003723	subunit interface [polypeptide binding]; other site
866777003724	transcription antitermination factor NusB; Region: nusB; TIGR01951
866777003725	putative RNA binding site [nucleotide binding]; other site
866777003726	elongation factor P; Validated; Region: PRK00529
866777003727	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
866777003728	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
866777003729	RNA binding site [nucleotide binding]; other site
866777003730	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
866777003731	RNA binding site [nucleotide binding]; other site
866777003732	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777003733	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003734	Walker A/P-loop; other site
866777003735	ATP binding site [chemical binding]; other site
866777003736	Q-loop/lid; other site
866777003737	ABC transporter signature motif; other site
866777003738	Walker B; other site
866777003739	D-loop; other site
866777003740	H-loop/switch region; other site
866777003741	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
866777003742	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866777003743	metal binding site [ion binding]; metal-binding site
866777003744	active site
866777003745	I-site; other site
866777003746	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866777003747	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
866777003748	active site
866777003749	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
866777003750	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
866777003751	Predicted permeases [General function prediction only]; Region: COG0679
866777003752	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
866777003753	putative CoA binding site [chemical binding]; other site
866777003754	putative trimer interface [polypeptide binding]; other site
866777003755	maltose O-acetyltransferase; Provisional; Region: PRK10092
866777003756	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
866777003757	active site
866777003758	substrate binding site [chemical binding]; other site
866777003759	trimer interface [polypeptide binding]; other site
866777003760	CoA binding site [chemical binding]; other site
866777003761	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
866777003762	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866777003763	minor groove reading motif; other site
866777003764	helix-hairpin-helix signature motif; other site
866777003765	substrate binding pocket [chemical binding]; other site
866777003766	active site
866777003767	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
866777003768	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
866777003769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003770	Walker A/P-loop; other site
866777003771	ATP binding site [chemical binding]; other site
866777003772	Q-loop/lid; other site
866777003773	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
866777003774	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
866777003775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003776	ABC transporter signature motif; other site
866777003777	Walker B; other site
866777003778	D-loop; other site
866777003779	H-loop/switch region; other site
866777003780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003781	Walker A/P-loop; other site
866777003782	ATP binding site [chemical binding]; other site
866777003783	Q-loop/lid; other site
866777003784	ABC transporter signature motif; other site
866777003785	Walker B; other site
866777003786	D-loop; other site
866777003787	H-loop/switch region; other site
866777003788	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866777003789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866777003790	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866777003791	dimerization interface [polypeptide binding]; other site
866777003792	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866777003793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777003794	putative substrate translocation pore; other site
866777003795	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866777003796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866777003797	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866777003798	dimerization interface [polypeptide binding]; other site
866777003799	dimerization interface [polypeptide binding]; other site
866777003800	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
866777003801	putative active cleft [active]
866777003802	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777003803	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777003804	DNA binding site [nucleotide binding]
866777003805	domain linker motif; other site
866777003806	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777003807	ligand binding site [chemical binding]; other site
866777003808	dimerization interface [polypeptide binding]; other site
866777003809	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
866777003810	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
866777003811	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
866777003812	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
866777003813	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777003814	Walker A/P-loop; other site
866777003815	ATP binding site [chemical binding]; other site
866777003816	Q-loop/lid; other site
866777003817	ABC transporter signature motif; other site
866777003818	Walker B; other site
866777003819	D-loop; other site
866777003820	H-loop/switch region; other site
866777003821	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866777003822	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866777003823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777003824	dimer interface [polypeptide binding]; other site
866777003825	conserved gate region; other site
866777003826	putative PBP binding loops; other site
866777003827	ABC-ATPase subunit interface; other site
866777003828	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866777003829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777003830	dimer interface [polypeptide binding]; other site
866777003831	conserved gate region; other site
866777003832	putative PBP binding loops; other site
866777003833	ABC-ATPase subunit interface; other site
866777003834	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
866777003835	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866777003836	substrate binding site [chemical binding]; other site
866777003837	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
866777003838	beta-galactosidase; Region: BGL; TIGR03356
866777003839	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
866777003840	active site
866777003841	catalytic triad [active]
866777003842	oxyanion hole [active]
866777003843	Domain of unknown function (DUF303); Region: DUF303; pfam03629
866777003844	Response regulator receiver domain; Region: Response_reg; pfam00072
866777003845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777003846	active site
866777003847	phosphorylation site [posttranslational modification]
866777003848	intermolecular recognition site; other site
866777003849	dimerization interface [polypeptide binding]; other site
866777003850	AAA domain; Region: AAA_14; pfam13173
866777003851	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
866777003852	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866777003853	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
866777003854	catalytic Zn binding site [ion binding]; other site
866777003855	NAD(P) binding site [chemical binding]; other site
866777003856	structural Zn binding site [ion binding]; other site
866777003857	CrcB-like protein; Region: CRCB; pfam02537
866777003858	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
866777003859	Predicted membrane protein [Function unknown]; Region: COG2246
866777003860	GtrA-like protein; Region: GtrA; pfam04138
866777003861	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
866777003862	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866777003863	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866777003864	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866777003865	dimerization interface [polypeptide binding]; other site
866777003866	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
866777003867	elongation factor Tu; Reviewed; Region: PRK00049
866777003868	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
866777003869	G1 box; other site
866777003870	GEF interaction site [polypeptide binding]; other site
866777003871	GTP/Mg2+ binding site [chemical binding]; other site
866777003872	Switch I region; other site
866777003873	G2 box; other site
866777003874	G3 box; other site
866777003875	Switch II region; other site
866777003876	G4 box; other site
866777003877	G5 box; other site
866777003878	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
866777003879	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
866777003880	Antibiotic Binding Site [chemical binding]; other site
866777003881	elongation factor G; Reviewed; Region: PRK00007
866777003882	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
866777003883	G1 box; other site
866777003884	putative GEF interaction site [polypeptide binding]; other site
866777003885	GTP/Mg2+ binding site [chemical binding]; other site
866777003886	Switch I region; other site
866777003887	G2 box; other site
866777003888	G3 box; other site
866777003889	Switch II region; other site
866777003890	G4 box; other site
866777003891	G5 box; other site
866777003892	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
866777003893	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
866777003894	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
866777003895	30S ribosomal protein S7; Validated; Region: PRK05302
866777003896	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
866777003897	S17 interaction site [polypeptide binding]; other site
866777003898	S8 interaction site; other site
866777003899	16S rRNA interaction site [nucleotide binding]; other site
866777003900	streptomycin interaction site [chemical binding]; other site
866777003901	23S rRNA interaction site [nucleotide binding]; other site
866777003902	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
866777003903	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
866777003904	Sodium Bile acid symporter family; Region: SBF; pfam01758
866777003905	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
866777003906	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866777003907	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866777003908	catalytic residue [active]
866777003909	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
866777003910	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866777003911	putative ADP-binding pocket [chemical binding]; other site
866777003912	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
866777003913	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777003914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777003915	homodimer interface [polypeptide binding]; other site
866777003916	catalytic residue [active]
866777003917	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
866777003918	ATP-grasp domain; Region: ATP-grasp; pfam02222
866777003919	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
866777003920	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
866777003921	ATP binding site [chemical binding]; other site
866777003922	active site
866777003923	substrate binding site [chemical binding]; other site
866777003924	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
866777003925	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
866777003926	dimerization interface [polypeptide binding]; other site
866777003927	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
866777003928	dimerization interface [polypeptide binding]; other site
866777003929	ATP binding site [chemical binding]; other site
866777003930	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
866777003931	dimerization interface [polypeptide binding]; other site
866777003932	ATP binding site [chemical binding]; other site
866777003933	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
866777003934	putative active site [active]
866777003935	catalytic triad [active]
866777003936	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
866777003937	Yqey-like protein; Region: YqeY; cl17540
866777003938	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
866777003939	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
866777003940	putative active site [active]
866777003941	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
866777003942	DNA polymerase IV; Reviewed; Region: PRK03103
866777003943	Y-family of DNA polymerases; Region: PolY; cl12025
866777003944	active site
866777003945	DNA binding site [nucleotide binding]
866777003946	amidophosphoribosyltransferase; Provisional; Region: PRK07272
866777003947	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
866777003948	active site
866777003949	tetramer interface [polypeptide binding]; other site
866777003950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777003951	active site
866777003952	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
866777003953	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
866777003954	dimerization interface [polypeptide binding]; other site
866777003955	putative ATP binding site [chemical binding]; other site
866777003956	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
866777003957	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
866777003958	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
866777003959	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
866777003960	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
866777003961	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
866777003962	NAD(P) binding site [chemical binding]; other site
866777003963	catalytic residues [active]
866777003964	Sulfatase; Region: Sulfatase; pfam00884
866777003965	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
866777003966	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
866777003967	metal binding site [ion binding]; metal-binding site
866777003968	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
866777003969	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
866777003970	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
866777003971	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
866777003972	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
866777003973	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
866777003974	Predicted permease; Region: DUF318; cl17795
866777003975	TIGR03943 family protein; Region: TIGR03943
866777003976	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866777003977	metal binding site 2 [ion binding]; metal-binding site
866777003978	putative DNA binding helix; other site
866777003979	metal binding site 1 [ion binding]; metal-binding site
866777003980	dimer interface [polypeptide binding]; other site
866777003981	structural Zn2+ binding site [ion binding]; other site
866777003982	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777003983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777003984	Q-loop/lid; other site
866777003985	ABC transporter signature motif; other site
866777003986	Walker B; other site
866777003987	D-loop; other site
866777003988	H-loop/switch region; other site
866777003989	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866777003990	metal binding site 2 [ion binding]; metal-binding site
866777003991	putative DNA binding helix; other site
866777003992	metal binding site 1 [ion binding]; metal-binding site
866777003993	dimer interface [polypeptide binding]; other site
866777003994	structural Zn2+ binding site [ion binding]; other site
866777003995	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
866777003996	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
866777003997	NAD binding site [chemical binding]; other site
866777003998	ATP-grasp domain; Region: ATP-grasp; pfam02222
866777003999	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
866777004000	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
866777004001	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
866777004002	NAD(P) binding site [chemical binding]; other site
866777004003	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
866777004004	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
866777004005	TPP-binding site; other site
866777004006	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866777004007	PYR/PP interface [polypeptide binding]; other site
866777004008	dimer interface [polypeptide binding]; other site
866777004009	TPP binding site [chemical binding]; other site
866777004010	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866777004011	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777004012	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866777004013	FtsX-like permease family; Region: FtsX; pfam02687
866777004014	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777004015	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777004016	Walker A/P-loop; other site
866777004017	ATP binding site [chemical binding]; other site
866777004018	Q-loop/lid; other site
866777004019	ABC transporter signature motif; other site
866777004020	Walker B; other site
866777004021	D-loop; other site
866777004022	H-loop/switch region; other site
866777004023	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
866777004024	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866777004025	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
866777004026	Transposase; Region: HTH_Tnp_1; cl17663
866777004027	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
866777004028	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866777004029	Ca binding site [ion binding]; other site
866777004030	active site
866777004031	catalytic site [active]
866777004032	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
866777004033	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777004034	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777004035	DNA binding site [nucleotide binding]
866777004036	domain linker motif; other site
866777004037	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777004038	ligand binding site [chemical binding]; other site
866777004039	dimerization interface [polypeptide binding]; other site
866777004040	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777004041	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777004042	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866777004043	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866777004044	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866777004045	putative active site [active]
866777004046	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
866777004047	transmembrane helices; other site
866777004048	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
866777004049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866777004050	DNA-binding site [nucleotide binding]; DNA binding site
866777004051	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777004052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777004053	homodimer interface [polypeptide binding]; other site
866777004054	catalytic residue [active]
866777004055	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152
866777004056	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
866777004057	predicted active site [active]
866777004058	catalytic triad [active]
866777004059	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
866777004060	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
866777004061	active site
866777004062	multimer interface [polypeptide binding]; other site
866777004063	DNA primase, catalytic core; Region: dnaG; TIGR01391
866777004064	CHC2 zinc finger; Region: zf-CHC2; cl17510
866777004065	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
866777004066	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
866777004067	active site
866777004068	metal binding site [ion binding]; metal-binding site
866777004069	interdomain interaction site; other site
866777004070	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
866777004071	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
866777004072	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866777004073	Zn2+ binding site [ion binding]; other site
866777004074	Mg2+ binding site [ion binding]; other site
866777004075	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
866777004076	alanine racemase; Reviewed; Region: alr; PRK00053
866777004077	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
866777004078	active site
866777004079	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866777004080	dimer interface [polypeptide binding]; other site
866777004081	substrate binding site [chemical binding]; other site
866777004082	catalytic residues [active]
866777004083	amino acid transporter; Region: 2A0306; TIGR00909
866777004084	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
866777004085	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
866777004086	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
866777004087	S-ribosylhomocysteinase; Provisional; Region: PRK02260
866777004088	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
866777004089	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777004090	ATP binding site [chemical binding]; other site
866777004091	putative Mg++ binding site [ion binding]; other site
866777004092	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777004093	nucleotide binding region [chemical binding]; other site
866777004094	ATP-binding site [chemical binding]; other site
866777004095	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
866777004096	HRDC domain; Region: HRDC; pfam00570
866777004097	cystathionine gamma-synthase; Provisional; Region: PRK07811
866777004098	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866777004099	homodimer interface [polypeptide binding]; other site
866777004100	substrate-cofactor binding pocket; other site
866777004101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777004102	catalytic residue [active]
866777004103	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866777004104	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866777004105	dimer interface [polypeptide binding]; other site
866777004106	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777004107	catalytic residue [active]
866777004108	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866777004109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004110	ABC-ATPase subunit interface; other site
866777004111	putative PBP binding loops; other site
866777004112	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866777004113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004114	putative PBP binding loops; other site
866777004115	ABC-ATPase subunit interface; other site
866777004116	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
866777004117	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
866777004118	pantothenate kinase; Reviewed; Region: PRK13318
866777004119	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866777004120	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777004121	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777004122	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777004123	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
866777004124	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
866777004125	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
866777004126	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
866777004127	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777004128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004129	dimer interface [polypeptide binding]; other site
866777004130	conserved gate region; other site
866777004131	putative PBP binding loops; other site
866777004132	ABC-ATPase subunit interface; other site
866777004133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004134	dimer interface [polypeptide binding]; other site
866777004135	conserved gate region; other site
866777004136	putative PBP binding loops; other site
866777004137	ABC-ATPase subunit interface; other site
866777004138	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777004139	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777004140	DNA binding site [nucleotide binding]
866777004141	domain linker motif; other site
866777004142	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
866777004143	ligand binding site [chemical binding]; other site
866777004144	dimerization interface (open form) [polypeptide binding]; other site
866777004145	dimerization interface (closed form) [polypeptide binding]; other site
866777004146	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
866777004147	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866777004148	active site
866777004149	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
866777004150	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
866777004151	glutaminase active site [active]
866777004152	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
866777004153	dimer interface [polypeptide binding]; other site
866777004154	active site
866777004155	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866777004156	dimer interface [polypeptide binding]; other site
866777004157	active site
866777004158	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866777004159	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866777004160	Walker A/P-loop; other site
866777004161	ATP binding site [chemical binding]; other site
866777004162	Q-loop/lid; other site
866777004163	ABC transporter signature motif; other site
866777004164	Walker B; other site
866777004165	D-loop; other site
866777004166	H-loop/switch region; other site
866777004167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004168	dimer interface [polypeptide binding]; other site
866777004169	conserved gate region; other site
866777004170	putative PBP binding loops; other site
866777004171	ABC-ATPase subunit interface; other site
866777004172	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866777004173	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866777004174	substrate binding pocket [chemical binding]; other site
866777004175	membrane-bound complex binding site; other site
866777004176	hinge residues; other site
866777004177	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866777004178	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866777004179	substrate binding pocket [chemical binding]; other site
866777004180	membrane-bound complex binding site; other site
866777004181	hinge residues; other site
866777004182	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
866777004183	SmpB-tmRNA interface; other site
866777004184	CHAP domain; Region: CHAP; pfam05257
866777004185	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
866777004186	FtsX-like permease family; Region: FtsX; pfam02687
866777004187	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
866777004188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777004189	Walker A/P-loop; other site
866777004190	ATP binding site [chemical binding]; other site
866777004191	Q-loop/lid; other site
866777004192	ABC transporter signature motif; other site
866777004193	Walker B; other site
866777004194	D-loop; other site
866777004195	H-loop/switch region; other site
866777004196	peptide chain release factor 2; Validated; Region: prfB; PRK00578
866777004197	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
866777004198	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866777004199	RF-1 domain; Region: RF-1; pfam00472
866777004200	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
866777004201	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
866777004202	active site
866777004203	catalytic site [active]
866777004204	substrate binding site [chemical binding]; other site
866777004205	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
866777004206	active site
866777004207	catalytic residues [active]
866777004208	metal binding site [ion binding]; metal-binding site
866777004209	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
866777004210	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
866777004211	active site
866777004212	substrate binding site [chemical binding]; other site
866777004213	metal binding site [ion binding]; metal-binding site
866777004214	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
866777004215	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
866777004216	Zn binding site [ion binding]; other site
866777004217	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
866777004218	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866777004219	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
866777004220	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866777004221	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
866777004222	dimer interface [polypeptide binding]; other site
866777004223	active site
866777004224	catalytic residue [active]
866777004225	dihydrodipicolinate reductase; Provisional; Region: PRK00048
866777004226	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
866777004227	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
866777004228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777004229	putative substrate translocation pore; other site
866777004230	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866777004231	Part of AAA domain; Region: AAA_19; pfam13245
866777004232	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
866777004233	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
866777004234	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
866777004235	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
866777004236	Catalytic domain of Protein Kinases; Region: PKc; cd00180
866777004237	active site
866777004238	ATP binding site [chemical binding]; other site
866777004239	substrate binding site [chemical binding]; other site
866777004240	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
866777004241	substrate binding site [chemical binding]; other site
866777004242	activation loop (A-loop); other site
866777004243	activation loop (A-loop); other site
866777004244	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
866777004245	Interdomain contacts; other site
866777004246	Cytokine receptor motif; other site
866777004247	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
866777004248	Interdomain contacts; other site
866777004249	Cytokine receptor motif; other site
866777004250	MoxR-like ATPases [General function prediction only]; Region: COG0714
866777004251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777004252	Walker A motif; other site
866777004253	ATP binding site [chemical binding]; other site
866777004254	Walker B motif; other site
866777004255	arginine finger; other site
866777004256	Protein of unknown function DUF58; Region: DUF58; pfam01882
866777004257	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
866777004258	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
866777004259	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
866777004260	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
866777004261	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
866777004262	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
866777004263	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
866777004264	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
866777004265	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
866777004266	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
866777004267	DNA binding site [nucleotide binding]
866777004268	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
866777004269	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
866777004270	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
866777004271	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
866777004272	RPB1 interaction site [polypeptide binding]; other site
866777004273	RPB10 interaction site [polypeptide binding]; other site
866777004274	RPB11 interaction site [polypeptide binding]; other site
866777004275	RPB3 interaction site [polypeptide binding]; other site
866777004276	RPB12 interaction site [polypeptide binding]; other site
866777004277	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
866777004278	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866777004279	minor groove reading motif; other site
866777004280	helix-hairpin-helix signature motif; other site
866777004281	active site
866777004282	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
866777004283	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
866777004284	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
866777004285	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
866777004286	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
866777004287	galactokinase; Provisional; Region: PRK05322
866777004288	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866777004289	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866777004290	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
866777004291	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
866777004292	dimer interface [polypeptide binding]; other site
866777004293	active site
866777004294	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866777004295	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866777004296	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866777004297	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
866777004298	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
866777004299	quinone interaction residues [chemical binding]; other site
866777004300	active site
866777004301	catalytic residues [active]
866777004302	FMN binding site [chemical binding]; other site
866777004303	substrate binding site [chemical binding]; other site
866777004304	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866777004305	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
866777004306	active site
866777004307	FMN binding site [chemical binding]; other site
866777004308	substrate binding site [chemical binding]; other site
866777004309	homotetramer interface [polypeptide binding]; other site
866777004310	catalytic residue [active]
866777004311	Transglycosylase; Region: Transgly; pfam00912
866777004312	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866777004313	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866777004314	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
866777004315	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866777004316	ligand binding site [chemical binding]; other site
866777004317	flexible hinge region; other site
866777004318	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
866777004319	putative switch regulator; other site
866777004320	non-specific DNA interactions [nucleotide binding]; other site
866777004321	DNA binding site [nucleotide binding]
866777004322	sequence specific DNA binding site [nucleotide binding]; other site
866777004323	putative cAMP binding site [chemical binding]; other site
866777004324	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866777004325	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
866777004326	tartrate dehydrogenase; Region: TTC; TIGR02089
866777004327	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
866777004328	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866777004329	Uncharacterized conserved protein [Function unknown]; Region: COG4850
866777004330	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
866777004331	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
866777004332	lipoyl attachment site [posttranslational modification]; other site
866777004333	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
866777004334	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
866777004335	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
866777004336	putative NADH binding site [chemical binding]; other site
866777004337	putative active site [active]
866777004338	nudix motif; other site
866777004339	putative metal binding site [ion binding]; other site
866777004340	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866777004341	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
866777004342	nudix motif; other site
866777004343	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866777004344	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866777004345	catalytic residues [active]
866777004346	Domain of unknown function (DUF348); Region: DUF348; pfam03990
866777004347	G5 domain; Region: G5; pfam07501
866777004348	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866777004349	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866777004350	catalytic residue [active]
866777004351	Chain length determinant protein; Region: Wzz; cl15801
866777004352	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
866777004353	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
866777004354	Nucleotide binding site [chemical binding]; other site
866777004355	DTAP/Switch II; other site
866777004356	Switch I; other site
866777004357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
866777004358	Integrase core domain; Region: rve; pfam00665
866777004359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866777004360	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
866777004361	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
866777004362	Int/Topo IB signature motif; other site
866777004363	INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187
866777004364	Int/Topo IB signature motif; other site
866777004365	transposase/IS protein; Provisional; Region: PRK09183
866777004366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777004367	Walker A motif; other site
866777004368	ATP binding site [chemical binding]; other site
866777004369	Walker B motif; other site
866777004370	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
866777004371	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
866777004372	CRISPR-associated protein Cas4; Region: cas4; TIGR00372
866777004373	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
866777004374	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
866777004375	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
866777004376	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866777004377	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
866777004378	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
866777004379	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
866777004380	HIGH motif; other site
866777004381	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
866777004382	active site
866777004383	KMSKS motif; other site
866777004384	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
866777004385	tRNA binding surface [nucleotide binding]; other site
866777004386	anticodon binding site; other site
866777004387	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777004388	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866777004389	substrate binding site [chemical binding]; other site
866777004390	dimer interface [polypeptide binding]; other site
866777004391	ATP binding site [chemical binding]; other site
866777004392	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
866777004393	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
866777004394	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
866777004395	ligand binding site [chemical binding]; other site
866777004396	dimerization interface [polypeptide binding]; other site
866777004397	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866777004398	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866777004399	TM-ABC transporter signature motif; other site
866777004400	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
866777004401	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866777004402	Walker A/P-loop; other site
866777004403	ATP binding site [chemical binding]; other site
866777004404	Q-loop/lid; other site
866777004405	ABC transporter signature motif; other site
866777004406	Walker B; other site
866777004407	D-loop; other site
866777004408	H-loop/switch region; other site
866777004409	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866777004410	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777004411	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777004412	DNA binding site [nucleotide binding]
866777004413	domain linker motif; other site
866777004414	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777004415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777004416	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866777004417	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777004418	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866777004419	substrate binding site [chemical binding]; other site
866777004420	dimer interface [polypeptide binding]; other site
866777004421	ATP binding site [chemical binding]; other site
866777004422	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
866777004423	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
866777004424	dimer interface [polypeptide binding]; other site
866777004425	active site
866777004426	metal binding site [ion binding]; metal-binding site
866777004427	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
866777004428	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777004429	motif II; other site
866777004430	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
866777004431	active site
866777004432	tetramer interface [polypeptide binding]; other site
866777004433	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
866777004434	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777004435	substrate binding site [chemical binding]; other site
866777004436	ATP binding site [chemical binding]; other site
866777004437	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
866777004438	active site
866777004439	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866777004440	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777004441	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777004442	DNA binding site [nucleotide binding]
866777004443	domain linker motif; other site
866777004444	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777004445	dimerization interface [polypeptide binding]; other site
866777004446	ligand binding site [chemical binding]; other site
866777004447	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777004448	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866777004449	substrate binding site [chemical binding]; other site
866777004450	dimer interface [polypeptide binding]; other site
866777004451	ATP binding site [chemical binding]; other site
866777004452	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
866777004453	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777004454	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866777004455	Walker A/P-loop; other site
866777004456	ATP binding site [chemical binding]; other site
866777004457	Q-loop/lid; other site
866777004458	ABC transporter signature motif; other site
866777004459	Walker B; other site
866777004460	D-loop; other site
866777004461	H-loop/switch region; other site
866777004462	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866777004463	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777004464	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777004465	Walker A/P-loop; other site
866777004466	ATP binding site [chemical binding]; other site
866777004467	Q-loop/lid; other site
866777004468	ABC transporter signature motif; other site
866777004469	Walker B; other site
866777004470	D-loop; other site
866777004471	H-loop/switch region; other site
866777004472	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866777004473	MarR family; Region: MarR_2; pfam12802
866777004474	MarR family; Region: MarR_2; cl17246
866777004475	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
866777004476	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866777004477	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
866777004478	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
866777004479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777004480	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777004481	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
866777004482	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
866777004483	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
866777004484	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
866777004485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777004486	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866777004487	putative substrate translocation pore; other site
866777004488	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777004489	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777004490	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
866777004491	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
866777004492	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
866777004493	active site
866777004494	NTP binding site [chemical binding]; other site
866777004495	metal binding triad [ion binding]; metal-binding site
866777004496	antibiotic binding site [chemical binding]; other site
866777004497	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
866777004498	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
866777004499	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
866777004500	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777004501	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777004502	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
866777004503	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
866777004504	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
866777004505	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
866777004506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
866777004507	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
866777004508	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
866777004509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
866777004510	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
866777004511	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866777004512	FeS/SAM binding site; other site
866777004513	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
866777004514	ATP cone domain; Region: ATP-cone; pfam03477
866777004515	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866777004516	Class III ribonucleotide reductase; Region: RNR_III; cd01675
866777004517	active site
866777004518	Zn binding site [ion binding]; other site
866777004519	glycine loop; other site
866777004520	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
866777004521	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
866777004522	generic binding surface II; other site
866777004523	generic binding surface I; other site
866777004524	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
866777004525	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
866777004526	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
866777004527	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
866777004528	acyl-activating enzyme (AAE) consensus motif; other site
866777004529	putative AMP binding site [chemical binding]; other site
866777004530	putative active site [active]
866777004531	putative CoA binding site [chemical binding]; other site
866777004532	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
866777004533	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
866777004534	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
866777004535	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
866777004536	putative catalytic site [active]
866777004537	putative metal binding site [ion binding]; other site
866777004538	putative phosphate binding site [ion binding]; other site
866777004539	exopolyphosphatase; Region: exo_poly_only; TIGR03706
866777004540	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
866777004541	aminotransferase; Validated; Region: PRK07337
866777004542	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777004543	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777004544	homodimer interface [polypeptide binding]; other site
866777004545	catalytic residue [active]
866777004546	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866777004547	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866777004548	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866777004549	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
866777004550	additional DNA contacts [nucleotide binding]; other site
866777004551	mismatch recognition site; other site
866777004552	active site
866777004553	zinc binding site [ion binding]; other site
866777004554	DNA intercalation site [nucleotide binding]; other site
866777004555	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
866777004556	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866777004557	Coenzyme A binding pocket [chemical binding]; other site
866777004558	SWIM zinc finger; Region: SWIM; pfam04434
866777004559	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
866777004560	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
866777004561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777004562	ATP binding site [chemical binding]; other site
866777004563	putative Mg++ binding site [ion binding]; other site
866777004564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777004565	nucleotide binding region [chemical binding]; other site
866777004566	ATP-binding site [chemical binding]; other site
866777004567	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
866777004568	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
866777004569	putative trimer interface [polypeptide binding]; other site
866777004570	putative CoA binding site [chemical binding]; other site
866777004571	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
866777004572	Citrate synthase; Region: Citrate_synt; pfam00285
866777004573	oxalacetate binding site [chemical binding]; other site
866777004574	citrylCoA binding site [chemical binding]; other site
866777004575	coenzyme A binding site [chemical binding]; other site
866777004576	catalytic triad [active]
866777004577	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
866777004578	active site
866777004579	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
866777004580	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
866777004581	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
866777004582	active site
866777004583	Zn binding site [ion binding]; other site
866777004584	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
866777004585	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
866777004586	dimer interface [polypeptide binding]; other site
866777004587	ssDNA binding site [nucleotide binding]; other site
866777004588	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866777004589	prolyl-tRNA synthetase; Provisional; Region: PRK09194
866777004590	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
866777004591	dimer interface [polypeptide binding]; other site
866777004592	motif 1; other site
866777004593	active site
866777004594	motif 2; other site
866777004595	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
866777004596	putative deacylase active site [active]
866777004597	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866777004598	active site
866777004599	motif 3; other site
866777004600	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
866777004601	anticodon binding site; other site
866777004602	AMMECR1; Region: AMMECR1; cl00911
866777004603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777004604	PIF1-like helicase; Region: PIF1; pfam05970
866777004605	Walker A motif; other site
866777004606	ATP binding site [chemical binding]; other site
866777004607	Walker B motif; other site
866777004608	arginine finger; other site
866777004609	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
866777004610	catalytic site [active]
866777004611	putative active site [active]
866777004612	putative substrate binding site [chemical binding]; other site
866777004613	dimer interface [polypeptide binding]; other site
866777004614	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
866777004615	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866777004616	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
866777004617	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866777004618	active site
866777004619	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
866777004620	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
866777004621	Mg++ binding site [ion binding]; other site
866777004622	putative catalytic motif [active]
866777004623	substrate binding site [chemical binding]; other site
866777004624	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
866777004625	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
866777004626	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
866777004627	Walker A/P-loop; other site
866777004628	ATP binding site [chemical binding]; other site
866777004629	Q-loop/lid; other site
866777004630	ABC transporter signature motif; other site
866777004631	Walker B; other site
866777004632	D-loop; other site
866777004633	H-loop/switch region; other site
866777004634	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
866777004635	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
866777004636	Walker A/P-loop; other site
866777004637	ATP binding site [chemical binding]; other site
866777004638	Q-loop/lid; other site
866777004639	ABC transporter signature motif; other site
866777004640	Walker B; other site
866777004641	D-loop; other site
866777004642	H-loop/switch region; other site
866777004643	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
866777004644	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
866777004645	TM-ABC transporter signature motif; other site
866777004646	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866777004647	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
866777004648	TM-ABC transporter signature motif; other site
866777004649	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866777004650	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
866777004651	putative ligand binding site [chemical binding]; other site
866777004652	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
866777004653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777004654	S-adenosylmethionine binding site [chemical binding]; other site
866777004655	peptide chain release factor 1; Validated; Region: prfA; PRK00591
866777004656	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866777004657	RF-1 domain; Region: RF-1; pfam00472
866777004658	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
866777004659	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
866777004660	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
866777004661	active site
866777004662	catalytic residues [active]
866777004663	metal binding site [ion binding]; metal-binding site
866777004664	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866777004665	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866777004666	active site
866777004667	catalytic tetrad [active]
866777004668	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866777004669	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
866777004670	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866777004671	nucleotide binding site [chemical binding]; other site
866777004672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777004673	putative substrate translocation pore; other site
866777004674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777004675	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
866777004676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777004677	Walker A/P-loop; other site
866777004678	ATP binding site [chemical binding]; other site
866777004679	Q-loop/lid; other site
866777004680	ABC transporter signature motif; other site
866777004681	Walker B; other site
866777004682	D-loop; other site
866777004683	H-loop/switch region; other site
866777004684	ABC transporter; Region: ABC_tran_2; pfam12848
866777004685	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866777004686	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
866777004687	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
866777004688	active site
866777004689	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
866777004690	catalytic triad [active]
866777004691	dimer interface [polypeptide binding]; other site
866777004692	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
866777004693	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
866777004694	homooctamer interface [polypeptide binding]; other site
866777004695	active site
866777004696	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
866777004697	catalytic center binding site [active]
866777004698	ATP binding site [chemical binding]; other site
866777004699	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
866777004700	catalytic center binding site [active]
866777004701	ATP binding site [chemical binding]; other site
866777004702	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
866777004703	dihydropteroate synthase; Region: DHPS; TIGR01496
866777004704	substrate binding pocket [chemical binding]; other site
866777004705	dimer interface [polypeptide binding]; other site
866777004706	inhibitor binding site; inhibition site
866777004707	GTP cyclohydrolase I; Provisional; Region: PLN03044
866777004708	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
866777004709	active site
866777004710	FtsH Extracellular; Region: FtsH_ext; pfam06480
866777004711	Preprotein translocase subunit; Region: YajC; cl00806
866777004712	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
866777004713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777004714	Walker A motif; other site
866777004715	ATP binding site [chemical binding]; other site
866777004716	Walker B motif; other site
866777004717	arginine finger; other site
866777004718	Peptidase family M41; Region: Peptidase_M41; pfam01434
866777004719	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777004720	active site
866777004721	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
866777004722	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
866777004723	Ligand Binding Site [chemical binding]; other site
866777004724	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
866777004725	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
866777004726	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866777004727	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866777004728	Walker A/P-loop; other site
866777004729	ATP binding site [chemical binding]; other site
866777004730	Q-loop/lid; other site
866777004731	ABC transporter signature motif; other site
866777004732	Walker B; other site
866777004733	D-loop; other site
866777004734	H-loop/switch region; other site
866777004735	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866777004736	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
866777004737	DXD motif; other site
866777004738	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866777004739	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866777004740	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
866777004741	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866777004742	active site
866777004743	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
866777004744	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
866777004745	dimer interface [polypeptide binding]; other site
866777004746	active site
866777004747	metal binding site [ion binding]; metal-binding site
866777004748	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
866777004749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777004750	S-adenosylmethionine binding site [chemical binding]; other site
866777004751	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
866777004752	Helix-turn-helix domain; Region: HTH_36; pfam13730
866777004753	Transcription factor WhiB; Region: Whib; pfam02467
866777004754	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
866777004755	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866777004756	P-loop; other site
866777004757	Magnesium ion binding site [ion binding]; other site
866777004758	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866777004759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777004760	Walker A/P-loop; other site
866777004761	ATP binding site [chemical binding]; other site
866777004762	Q-loop/lid; other site
866777004763	ABC transporter signature motif; other site
866777004764	Walker B; other site
866777004765	D-loop; other site
866777004766	H-loop/switch region; other site
866777004767	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866777004768	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866777004769	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866777004770	Coenzyme A binding pocket [chemical binding]; other site
866777004771	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
866777004772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777004773	motif II; other site
866777004774	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
866777004775	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
866777004776	DNA binding residues [nucleotide binding]
866777004777	PIN domain; Region: PIN_3; pfam13470
866777004778	PrgI family protein; Region: PrgI; pfam12666
866777004779	AAA-like domain; Region: AAA_10; pfam12846
866777004780	Domain of unknown function DUF87; Region: DUF87; pfam01935
866777004781	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866777004782	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866777004783	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866777004784	catalytic residue [active]
866777004785	Surface antigen [General function prediction only]; Region: COG3942
866777004786	CHAP domain; Region: CHAP; pfam05257
866777004787	Predicted ATPase [General function prediction only]; Region: COG4637
866777004788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777004789	Walker A/P-loop; other site
866777004790	ATP binding site [chemical binding]; other site
866777004791	Antirestriction protein (ArdA); Region: ArdA; cl01953
866777004792	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
866777004793	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
866777004794	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
866777004795	ParB-like nuclease domain; Region: ParBc; pfam02195
866777004796	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866777004797	DNA binding site [nucleotide binding]
866777004798	active site
866777004799	Int/Topo IB signature motif; other site
866777004800	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
866777004801	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
866777004802	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
866777004803	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
866777004804	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
866777004805	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
866777004806	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
866777004807	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777004808	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777004809	DNA binding site [nucleotide binding]
866777004810	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
866777004811	putative ligand binding site [chemical binding]; other site
866777004812	putative dimerization interface [polypeptide binding]; other site
866777004813	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
866777004814	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777004815	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777004816	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777004817	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777004818	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
866777004819	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
866777004820	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
866777004821	putative active site [active]
866777004822	Integrase core domain; Region: rve; pfam00665
866777004823	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866777004824	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777004825	FtsX-like permease family; Region: FtsX; pfam02687
866777004826	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777004827	FtsX-like permease family; Region: FtsX; pfam02687
866777004828	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777004829	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777004830	Walker A/P-loop; other site
866777004831	ATP binding site [chemical binding]; other site
866777004832	Q-loop/lid; other site
866777004833	ABC transporter signature motif; other site
866777004834	Walker B; other site
866777004835	D-loop; other site
866777004836	H-loop/switch region; other site
866777004837	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866777004838	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
866777004839	active site
866777004840	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
866777004841	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
866777004842	folate binding site [chemical binding]; other site
866777004843	NADP+ binding site [chemical binding]; other site
866777004844	thymidylate synthase; Reviewed; Region: thyA; PRK01827
866777004845	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
866777004846	dimerization interface [polypeptide binding]; other site
866777004847	active site
866777004848	OsmC-like protein; Region: OsmC; pfam02566
866777004849	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866777004850	Ligand Binding Site [chemical binding]; other site
866777004851	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866777004852	Ligand Binding Site [chemical binding]; other site
866777004853	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866777004854	NlpC/P60 family; Region: NLPC_P60; pfam00877
866777004855	NlpC/P60 family; Region: NLPC_P60; cl17555
866777004856	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866777004857	CHAP domain; Region: CHAP; pfam05257
866777004858	phosphoserine aminotransferase; Provisional; Region: PRK03080
866777004859	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866777004860	catalytic residue [active]
866777004861	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
866777004862	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777004863	ATP binding site [chemical binding]; other site
866777004864	Mg2+ binding site [ion binding]; other site
866777004865	G-X-G motif; other site
866777004866	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
866777004867	PhoU domain; Region: PhoU; pfam01895
866777004868	PhoU domain; Region: PhoU; pfam01895
866777004869	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777004870	catalytic core [active]
866777004871	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
866777004872	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
866777004873	UbiA prenyltransferase family; Region: UbiA; pfam01040
866777004874	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
866777004875	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
866777004876	dimer interface [polypeptide binding]; other site
866777004877	putative anticodon binding site; other site
866777004878	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866777004879	motif 1; other site
866777004880	dimer interface [polypeptide binding]; other site
866777004881	active site
866777004882	motif 2; other site
866777004883	motif 3; other site
866777004884	MFS transport protein AraJ; Provisional; Region: PRK10091
866777004885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777004886	putative substrate translocation pore; other site
866777004887	Tetratricopeptide repeat; Region: TPR_12; pfam13424
866777004888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866777004889	binding surface
866777004890	TPR motif; other site
866777004891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
866777004892	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
866777004893	Protein of unknown function (DUF4125); Region: DUF4125; pfam13526
866777004894	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
866777004895	PspC domain; Region: PspC; pfam04024
866777004896	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866777004897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777004898	ATP binding site [chemical binding]; other site
866777004899	Mg2+ binding site [ion binding]; other site
866777004900	G-X-G motif; other site
866777004901	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866777004902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777004903	active site
866777004904	phosphorylation site [posttranslational modification]
866777004905	intermolecular recognition site; other site
866777004906	dimerization interface [polypeptide binding]; other site
866777004907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866777004908	DNA binding residues [nucleotide binding]
866777004909	dimerization interface [polypeptide binding]; other site
866777004910	UDP-glucose 4-epimerase; Region: PLN02240
866777004911	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
866777004912	NAD binding site [chemical binding]; other site
866777004913	homodimer interface [polypeptide binding]; other site
866777004914	active site
866777004915	substrate binding site [chemical binding]; other site
866777004916	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
866777004917	Phosphotransferase enzyme family; Region: APH; pfam01636
866777004918	active site
866777004919	substrate binding site [chemical binding]; other site
866777004920	ATP binding site [chemical binding]; other site
866777004921	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
866777004922	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
866777004923	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777004924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004925	dimer interface [polypeptide binding]; other site
866777004926	conserved gate region; other site
866777004927	putative PBP binding loops; other site
866777004928	ABC-ATPase subunit interface; other site
866777004929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777004930	dimer interface [polypeptide binding]; other site
866777004931	conserved gate region; other site
866777004932	ABC-ATPase subunit interface; other site
866777004933	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777004934	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777004935	seryl-tRNA synthetase; Provisional; Region: PRK05431
866777004936	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
866777004937	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
866777004938	dimer interface [polypeptide binding]; other site
866777004939	active site
866777004940	motif 1; other site
866777004941	motif 2; other site
866777004942	motif 3; other site
866777004943	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
866777004944	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866777004945	transcriptional antiterminator BglG; Provisional; Region: PRK09772
866777004946	CAT RNA binding domain; Region: CAT_RBD; smart01061
866777004947	PRD domain; Region: PRD; pfam00874
866777004948	PRD domain; Region: PRD; pfam00874
866777004949	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
866777004950	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866777004951	active site turn [active]
866777004952	phosphorylation site [posttranslational modification]
866777004953	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866777004954	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
866777004955	HPr interaction site; other site
866777004956	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866777004957	active site
866777004958	phosphorylation site [posttranslational modification]
866777004959	phosphoglucomutase; Validated; Region: PRK07564
866777004960	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
866777004961	active site
866777004962	substrate binding site [chemical binding]; other site
866777004963	metal binding site [ion binding]; metal-binding site
866777004964	Transcriptional regulator; Region: Rrf2; pfam02082
866777004965	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
866777004966	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866777004967	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866777004968	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
866777004969	RNA/DNA hybrid binding site [nucleotide binding]; other site
866777004970	active site
866777004971	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
866777004972	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866777004973	active site
866777004974	dimer interface [polypeptide binding]; other site
866777004975	DNA repair protein RadA; Provisional; Region: PRK11823
866777004976	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866777004977	Walker A motif; other site
866777004978	ATP binding site [chemical binding]; other site
866777004979	Walker B motif; other site
866777004980	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
866777004981	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
866777004982	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
866777004983	active site
866777004984	Riboflavin kinase; Region: Flavokinase; smart00904
866777004985	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
866777004986	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
866777004987	RNA binding site [nucleotide binding]; other site
866777004988	active site
866777004989	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
866777004990	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
866777004991	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
866777004992	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
866777004993	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
866777004994	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
866777004995	G1 box; other site
866777004996	putative GEF interaction site [polypeptide binding]; other site
866777004997	GTP/Mg2+ binding site [chemical binding]; other site
866777004998	Switch I region; other site
866777004999	G2 box; other site
866777005000	G3 box; other site
866777005001	Switch II region; other site
866777005002	G4 box; other site
866777005003	G5 box; other site
866777005004	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
866777005005	Translation-initiation factor 2; Region: IF-2; pfam11987
866777005006	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
866777005007	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
866777005008	NusA N-terminal domain; Region: NusA_N; pfam08529
866777005009	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
866777005010	RNA binding site [nucleotide binding]; other site
866777005011	homodimer interface [polypeptide binding]; other site
866777005012	NusA-like KH domain; Region: KH_5; pfam13184
866777005013	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
866777005014	G-X-X-G motif; other site
866777005015	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005016	dimerization interface [polypeptide binding]; other site
866777005017	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005018	ligand binding site [chemical binding]; other site
866777005019	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
866777005020	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
866777005021	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
866777005022	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
866777005023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
866777005024	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
866777005025	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
866777005026	dimerization interface 3.5A [polypeptide binding]; other site
866777005027	active site
866777005028	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
866777005029	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
866777005030	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
866777005031	alphaNTD homodimer interface [polypeptide binding]; other site
866777005032	alphaNTD - beta interaction site [polypeptide binding]; other site
866777005033	alphaNTD - beta' interaction site [polypeptide binding]; other site
866777005034	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
866777005035	30S ribosomal protein S11; Validated; Region: PRK05309
866777005036	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
866777005037	30S ribosomal protein S13; Region: bact_S13; TIGR03631
866777005038	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
866777005039	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
866777005040	rRNA binding site [nucleotide binding]; other site
866777005041	predicted 30S ribosome binding site; other site
866777005042	adenylate kinase; Reviewed; Region: adk; PRK00279
866777005043	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
866777005044	AMP-binding site [chemical binding]; other site
866777005045	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
866777005046	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
866777005047	SecY translocase; Region: SecY; pfam00344
866777005048	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
866777005049	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
866777005050	23S rRNA binding site [nucleotide binding]; other site
866777005051	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
866777005052	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
866777005053	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
866777005054	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
866777005055	23S rRNA interface [nucleotide binding]; other site
866777005056	L21e interface [polypeptide binding]; other site
866777005057	5S rRNA interface [nucleotide binding]; other site
866777005058	L27 interface [polypeptide binding]; other site
866777005059	L5 interface [polypeptide binding]; other site
866777005060	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
866777005061	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866777005062	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866777005063	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
866777005064	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
866777005065	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
866777005066	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
866777005067	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
866777005068	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
866777005069	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
866777005070	RNA binding site [nucleotide binding]; other site
866777005071	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
866777005072	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
866777005073	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
866777005074	23S rRNA interface [nucleotide binding]; other site
866777005075	putative translocon interaction site; other site
866777005076	signal recognition particle (SRP54) interaction site; other site
866777005077	L23 interface [polypeptide binding]; other site
866777005078	trigger factor interaction site; other site
866777005079	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
866777005080	23S rRNA interface [nucleotide binding]; other site
866777005081	5S rRNA interface [nucleotide binding]; other site
866777005082	putative antibiotic binding site [chemical binding]; other site
866777005083	L25 interface [polypeptide binding]; other site
866777005084	L27 interface [polypeptide binding]; other site
866777005085	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
866777005086	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
866777005087	G-X-X-G motif; other site
866777005088	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
866777005089	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
866777005090	putative translocon binding site; other site
866777005091	protein-rRNA interface [nucleotide binding]; other site
866777005092	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
866777005093	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
866777005094	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
866777005095	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
866777005096	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
866777005097	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
866777005098	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
866777005099	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
866777005100	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
866777005101	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
866777005102	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
866777005103	putative catalytic cysteine [active]
866777005104	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
866777005105	putative active site [active]
866777005106	metal binding site [ion binding]; metal-binding site
866777005107	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866777005108	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866777005109	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866777005110	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866777005111	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
866777005112	inhibitor binding site; inhibition site
866777005113	catalytic Zn binding site [ion binding]; other site
866777005114	structural Zn binding site [ion binding]; other site
866777005115	NADP binding site [chemical binding]; other site
866777005116	tetramer interface [polypeptide binding]; other site
866777005117	polyol permease family; Region: 2A0118; TIGR00897
866777005118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005119	putative substrate translocation pore; other site
866777005120	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
866777005121	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777005122	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777005123	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866777005124	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
866777005125	active site
866777005126	metal binding site [ion binding]; metal-binding site
866777005127	polyol permease family; Region: 2A0118; TIGR00897
866777005128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005129	putative substrate translocation pore; other site
866777005130	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
866777005131	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866777005132	putative NAD(P) binding site [chemical binding]; other site
866777005133	catalytic Zn binding site [ion binding]; other site
866777005134	pullulanase, type I; Region: pulA_typeI; TIGR02104
866777005135	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
866777005136	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
866777005137	active site
866777005138	catalytic site [active]
866777005139	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
866777005140	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
866777005141	23S rRNA interface [nucleotide binding]; other site
866777005142	L3 interface [polypeptide binding]; other site
866777005143	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
866777005144	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
866777005145	Uncharacterized conserved protein [Function unknown]; Region: COG1739
866777005146	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
866777005147	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
866777005148	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
866777005149	dimerization interface [polypeptide binding]; other site
866777005150	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866777005151	NAD binding site [chemical binding]; other site
866777005152	ligand binding site [chemical binding]; other site
866777005153	catalytic site [active]
866777005154	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
866777005155	beta-galactosidase; Region: BGL; TIGR03356
866777005156	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777005157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005158	dimer interface [polypeptide binding]; other site
866777005159	conserved gate region; other site
866777005160	putative PBP binding loops; other site
866777005161	ABC-ATPase subunit interface; other site
866777005162	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777005163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005164	dimer interface [polypeptide binding]; other site
866777005165	conserved gate region; other site
866777005166	putative PBP binding loops; other site
866777005167	ABC-ATPase subunit interface; other site
866777005168	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777005169	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777005170	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005171	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777005172	DNA binding site [nucleotide binding]
866777005173	domain linker motif; other site
866777005174	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005175	dimerization interface [polypeptide binding]; other site
866777005176	ligand binding site [chemical binding]; other site
866777005177	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
866777005178	active site
866777005179	DNA polymerase IV; Validated; Region: PRK02406
866777005180	DNA binding site [nucleotide binding]
866777005181	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
866777005182	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777005183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777005184	homodimer interface [polypeptide binding]; other site
866777005185	catalytic residue [active]
866777005186	Ferredoxin [Energy production and conversion]; Region: COG1146
866777005187	4Fe-4S binding domain; Region: Fer4; pfam00037
866777005188	amino acid transporter; Region: 2A0306; TIGR00909
866777005189	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
866777005190	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
866777005191	FAD binding domain; Region: FAD_binding_4; pfam01565
866777005192	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
866777005193	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
866777005194	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
866777005195	oligomerisation interface [polypeptide binding]; other site
866777005196	mobile loop; other site
866777005197	roof hairpin; other site
866777005198	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866777005199	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866777005200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866777005201	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
866777005202	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
866777005203	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
866777005204	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
866777005205	Part of AAA domain; Region: AAA_19; pfam13245
866777005206	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
866777005207	phosphopeptide binding site; other site
866777005208	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
866777005209	peripheral dimer interface [polypeptide binding]; other site
866777005210	core dimer interface [polypeptide binding]; other site
866777005211	L10 interface [polypeptide binding]; other site
866777005212	L11 interface [polypeptide binding]; other site
866777005213	putative EF-Tu interaction site [polypeptide binding]; other site
866777005214	putative EF-G interaction site [polypeptide binding]; other site
866777005215	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
866777005216	23S rRNA interface [nucleotide binding]; other site
866777005217	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
866777005218	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
866777005219	Sulfate transporter family; Region: Sulfate_transp; pfam00916
866777005220	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
866777005221	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
866777005222	Walker A/P-loop; other site
866777005223	ATP binding site [chemical binding]; other site
866777005224	Q-loop/lid; other site
866777005225	ABC transporter signature motif; other site
866777005226	Walker B; other site
866777005227	D-loop; other site
866777005228	H-loop/switch region; other site
866777005229	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
866777005230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005231	dimer interface [polypeptide binding]; other site
866777005232	conserved gate region; other site
866777005233	putative PBP binding loops; other site
866777005234	ABC-ATPase subunit interface; other site
866777005235	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
866777005236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005237	dimer interface [polypeptide binding]; other site
866777005238	conserved gate region; other site
866777005239	putative PBP binding loops; other site
866777005240	ABC-ATPase subunit interface; other site
866777005241	PBP superfamily domain; Region: PBP_like_2; cl17296
866777005242	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866777005243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777005244	active site
866777005245	phosphorylation site [posttranslational modification]
866777005246	intermolecular recognition site; other site
866777005247	dimerization interface [polypeptide binding]; other site
866777005248	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866777005249	DNA binding site [nucleotide binding]
866777005250	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
866777005251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866777005252	dimer interface [polypeptide binding]; other site
866777005253	phosphorylation site [posttranslational modification]
866777005254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777005255	ATP binding site [chemical binding]; other site
866777005256	Mg2+ binding site [ion binding]; other site
866777005257	G-X-G motif; other site
866777005258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005259	metabolite-proton symporter; Region: 2A0106; TIGR00883
866777005260	putative substrate translocation pore; other site
866777005261	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
866777005262	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
866777005263	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
866777005264	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
866777005265	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
866777005266	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
866777005267	Domain of unknown function (DUF386); Region: DUF386; cl01047
866777005268	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
866777005269	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
866777005270	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
866777005271	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
866777005272	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
866777005273	beta-phosphoglucomutase; Region: bPGM; TIGR01990
866777005274	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777005275	active site
866777005276	motif I; other site
866777005277	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866777005278	EamA-like transporter family; Region: EamA; pfam00892
866777005279	EamA-like transporter family; Region: EamA; pfam00892
866777005280	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
866777005281	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
866777005282	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
866777005283	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
866777005284	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777005285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005286	dimer interface [polypeptide binding]; other site
866777005287	conserved gate region; other site
866777005288	putative PBP binding loops; other site
866777005289	ABC-ATPase subunit interface; other site
866777005290	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777005291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005292	dimer interface [polypeptide binding]; other site
866777005293	conserved gate region; other site
866777005294	putative PBP binding loops; other site
866777005295	ABC-ATPase subunit interface; other site
866777005296	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777005297	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866777005298	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005299	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777005300	DNA binding site [nucleotide binding]
866777005301	domain linker motif; other site
866777005302	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005303	dimerization interface [polypeptide binding]; other site
866777005304	ligand binding site [chemical binding]; other site
866777005305	MarC family integral membrane protein; Region: MarC; cl00919
866777005306	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
866777005307	trimer interface [polypeptide binding]; other site
866777005308	active site
866777005309	G bulge; other site
866777005310	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
866777005311	trimer interface [polypeptide binding]; other site
866777005312	active site
866777005313	G bulge; other site
866777005314	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
866777005315	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
866777005316	putative substrate binding pocket [chemical binding]; other site
866777005317	AC domain interface; other site
866777005318	catalytic triad [active]
866777005319	AB domain interface; other site
866777005320	interchain disulfide; other site
866777005321	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
866777005322	substrate binding site; other site
866777005323	dimer interface; other site
866777005324	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
866777005325	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
866777005326	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
866777005327	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
866777005328	Peptidase family U32; Region: Peptidase_U32; pfam01136
866777005329	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
866777005330	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
866777005331	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866777005332	S-adenosylmethionine binding site [chemical binding]; other site
866777005333	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
866777005334	ssDNA binding site; other site
866777005335	generic binding surface II; other site
866777005336	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866777005337	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866777005338	ATP binding site [chemical binding]; other site
866777005339	putative Mg++ binding site [ion binding]; other site
866777005340	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866777005341	nucleotide binding region [chemical binding]; other site
866777005342	ATP-binding site [chemical binding]; other site
866777005343	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
866777005344	YegV-like sugar kinase.  Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944
866777005345	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866777005346	substrate binding site [chemical binding]; other site
866777005347	ATP binding site [chemical binding]; other site
866777005348	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
866777005349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005350	putative substrate translocation pore; other site
866777005351	type II secretion system protein E; Region: type_II_gspE; TIGR02533
866777005352	RelB antitoxin; Region: RelB; cl01171
866777005353	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866777005354	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866777005355	non-specific DNA binding site [nucleotide binding]; other site
866777005356	salt bridge; other site
866777005357	sequence-specific DNA binding site [nucleotide binding]; other site
866777005358	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866777005359	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866777005360	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866777005361	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
866777005362	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
866777005363	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866777005364	phosphate binding site [ion binding]; other site
866777005365	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
866777005366	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
866777005367	putative active site [active]
866777005368	putative catalytic site [active]
866777005369	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
866777005370	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
866777005371	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
866777005372	putative NAD(P) binding site [chemical binding]; other site
866777005373	active site
866777005374	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
866777005375	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
866777005376	active site
866777005377	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
866777005378	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
866777005379	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
866777005380	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
866777005381	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866777005382	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866777005383	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
866777005384	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866777005385	carboxyltransferase (CT) interaction site; other site
866777005386	biotinylation site [posttranslational modification]; other site
866777005387	BioY family; Region: BioY; pfam02632
866777005388	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
866777005389	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
866777005390	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866777005391	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
866777005392	mRNA/rRNA interface [nucleotide binding]; other site
866777005393	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
866777005394	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
866777005395	23S rRNA interface [nucleotide binding]; other site
866777005396	L7/L12 interface [polypeptide binding]; other site
866777005397	putative thiostrepton binding site; other site
866777005398	L25 interface [polypeptide binding]; other site
866777005399	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
866777005400	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
866777005401	putative homodimer interface [polypeptide binding]; other site
866777005402	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
866777005403	heterodimer interface [polypeptide binding]; other site
866777005404	homodimer interface [polypeptide binding]; other site
866777005405	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
866777005406	aspartate aminotransferase; Provisional; Region: PRK05764
866777005407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866777005408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777005409	homodimer interface [polypeptide binding]; other site
866777005410	catalytic residue [active]
866777005411	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
866777005412	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
866777005413	putative active site [active]
866777005414	putative metal binding site [ion binding]; other site
866777005415	gamma-glutamyl kinase; Provisional; Region: PRK05429
866777005416	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
866777005417	nucleotide binding site [chemical binding]; other site
866777005418	homotetrameric interface [polypeptide binding]; other site
866777005419	putative phosphate binding site [ion binding]; other site
866777005420	putative allosteric binding site; other site
866777005421	PUA domain; Region: PUA; pfam01472
866777005422	GTPase CgtA; Reviewed; Region: obgE; PRK12296
866777005423	GTP1/OBG; Region: GTP1_OBG; pfam01018
866777005424	Obg GTPase; Region: Obg; cd01898
866777005425	G1 box; other site
866777005426	GTP/Mg2+ binding site [chemical binding]; other site
866777005427	Switch I region; other site
866777005428	G2 box; other site
866777005429	G3 box; other site
866777005430	Switch II region; other site
866777005431	G4 box; other site
866777005432	G5 box; other site
866777005433	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
866777005434	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
866777005435	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
866777005436	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
866777005437	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
866777005438	homodimer interface [polypeptide binding]; other site
866777005439	oligonucleotide binding site [chemical binding]; other site
866777005440	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
866777005441	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
866777005442	metal binding site [ion binding]; metal-binding site
866777005443	putative dimer interface [polypeptide binding]; other site
866777005444	Predicted permeases [General function prediction only]; Region: COG0679
866777005445	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866777005446	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
866777005447	inhibitor site; inhibition site
866777005448	active site
866777005449	dimer interface [polypeptide binding]; other site
866777005450	catalytic residue [active]
866777005451	Amidohydrolase; Region: Amidohydro_2; pfam04909
866777005452	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
866777005453	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
866777005454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005455	putative substrate translocation pore; other site
866777005456	short chain dehydrogenase; Provisional; Region: PRK08628
866777005457	classical (c) SDRs; Region: SDR_c; cd05233
866777005458	NAD(P) binding site [chemical binding]; other site
866777005459	active site
866777005460	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
866777005461	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
866777005462	metal binding site [ion binding]; metal-binding site
866777005463	substrate binding pocket [chemical binding]; other site
866777005464	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005465	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777005466	DNA binding site [nucleotide binding]
866777005467	domain linker motif; other site
866777005468	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005469	dimerization interface [polypeptide binding]; other site
866777005470	ligand binding site [chemical binding]; other site
866777005471	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
866777005472	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777005473	Walker A/P-loop; other site
866777005474	ATP binding site [chemical binding]; other site
866777005475	Q-loop/lid; other site
866777005476	ABC transporter signature motif; other site
866777005477	Walker B; other site
866777005478	D-loop; other site
866777005479	H-loop/switch region; other site
866777005480	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
866777005481	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866777005482	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
866777005483	putative active site [active]
866777005484	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
866777005485	dimer interface [polypeptide binding]; other site
866777005486	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
866777005487	nudix motif; other site
866777005488	homoserine kinase; Provisional; Region: PRK01212
866777005489	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866777005490	homoserine dehydrogenase; Provisional; Region: PRK06349
866777005491	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
866777005492	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
866777005493	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
866777005494	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
866777005495	catalytic residue [active]
866777005496	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
866777005497	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866777005498	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
866777005499	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
866777005500	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866777005501	active site
866777005502	HIGH motif; other site
866777005503	nucleotide binding site [chemical binding]; other site
866777005504	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
866777005505	KMSK motif region; other site
866777005506	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
866777005507	tRNA binding surface [nucleotide binding]; other site
866777005508	anticodon binding site; other site
866777005509	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866777005510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866777005511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005512	H+ Antiporter protein; Region: 2A0121; TIGR00900
866777005513	putative substrate translocation pore; other site
866777005514	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
866777005515	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
866777005516	hinge; other site
866777005517	active site
866777005518	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
866777005519	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866777005520	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866777005521	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866777005522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866777005523	substrate binding pocket [chemical binding]; other site
866777005524	membrane-bound complex binding site; other site
866777005525	hinge residues; other site
866777005526	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866777005527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005528	dimer interface [polypeptide binding]; other site
866777005529	conserved gate region; other site
866777005530	putative PBP binding loops; other site
866777005531	ABC-ATPase subunit interface; other site
866777005532	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866777005533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005534	dimer interface [polypeptide binding]; other site
866777005535	conserved gate region; other site
866777005536	putative PBP binding loops; other site
866777005537	ABC-ATPase subunit interface; other site
866777005538	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
866777005539	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866777005540	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866777005541	Walker A/P-loop; other site
866777005542	ATP binding site [chemical binding]; other site
866777005543	Q-loop/lid; other site
866777005544	ABC transporter signature motif; other site
866777005545	Walker B; other site
866777005546	D-loop; other site
866777005547	H-loop/switch region; other site
866777005548	Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810
866777005549	active site
866777005550	FMN binding site [chemical binding]; other site
866777005551	substrate binding site [chemical binding]; other site
866777005552	Protein of unknown function (DUF805); Region: DUF805; pfam05656
866777005553	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
866777005554	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
866777005555	substrate binding site [chemical binding]; other site
866777005556	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
866777005557	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
866777005558	substrate binding site [chemical binding]; other site
866777005559	ligand binding site [chemical binding]; other site
866777005560	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
866777005561	Transcriptional regulator [Transcription]; Region: IclR; COG1414
866777005562	Bacterial transcriptional regulator; Region: IclR; pfam01614
866777005563	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
866777005564	putative active site [active]
866777005565	putative metal binding site [ion binding]; other site
866777005566	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866777005567	polyphosphate kinase; Provisional; Region: PRK05443
866777005568	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
866777005569	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
866777005570	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
866777005571	putative domain interface [polypeptide binding]; other site
866777005572	putative active site [active]
866777005573	catalytic site [active]
866777005574	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
866777005575	putative domain interface [polypeptide binding]; other site
866777005576	putative active site [active]
866777005577	catalytic site [active]
866777005578	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
866777005579	active site
866777005580	Ap6A binding site [chemical binding]; other site
866777005581	nudix motif; other site
866777005582	metal binding site [ion binding]; metal-binding site
866777005583	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777005584	catalytic core [active]
866777005585	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
866777005586	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777005587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005588	ABC-ATPase subunit interface; other site
866777005589	putative PBP binding loops; other site
866777005590	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866777005591	active site
866777005592	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
866777005593	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
866777005594	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
866777005595	active site
866777005596	catalytic site [active]
866777005597	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
866777005598	active site
866777005599	HIGH motif; other site
866777005600	nucleotide binding site [chemical binding]; other site
866777005601	active site
866777005602	KMSKS motif; other site
866777005603	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
866777005604	Clp amino terminal domain; Region: Clp_N; pfam02861
866777005605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777005606	Walker A motif; other site
866777005607	ATP binding site [chemical binding]; other site
866777005608	Walker B motif; other site
866777005609	arginine finger; other site
866777005610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777005611	Walker A motif; other site
866777005612	ATP binding site [chemical binding]; other site
866777005613	Walker B motif; other site
866777005614	arginine finger; other site
866777005615	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866777005616	Membrane transport protein; Region: Mem_trans; cl09117
866777005617	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
866777005618	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
866777005619	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866777005620	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
866777005621	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866777005622	UDP-galactopyranose mutase; Region: GLF; pfam03275
866777005623	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
866777005624	tetramer interface [polypeptide binding]; other site
866777005625	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866777005626	active site
866777005627	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866777005628	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866777005629	TM-ABC transporter signature motif; other site
866777005630	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866777005631	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866777005632	TM-ABC transporter signature motif; other site
866777005633	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
866777005634	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866777005635	Walker A/P-loop; other site
866777005636	ATP binding site [chemical binding]; other site
866777005637	Q-loop/lid; other site
866777005638	ABC transporter signature motif; other site
866777005639	Walker B; other site
866777005640	D-loop; other site
866777005641	H-loop/switch region; other site
866777005642	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866777005643	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777005644	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
866777005645	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777005646	D-xylulose kinase; Region: XylB; TIGR01312
866777005647	nucleotide binding site [chemical binding]; other site
866777005648	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777005649	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777005650	nucleotide binding site [chemical binding]; other site
866777005651	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777005652	putative glycosyl transferase; Provisional; Region: PRK10073
866777005653	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866777005654	active site
866777005655	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
866777005656	Sulfatase; Region: Sulfatase; pfam00884
866777005657	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866777005658	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
866777005659	Probable Catalytic site; other site
866777005660	metal-binding site
866777005661	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
866777005662	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
866777005663	Probable Catalytic site; other site
866777005664	metal-binding site
866777005665	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866777005666	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
866777005667	Probable Catalytic site; other site
866777005668	metal-binding site
866777005669	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
866777005670	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
866777005671	Walker A/P-loop; other site
866777005672	ATP binding site [chemical binding]; other site
866777005673	Q-loop/lid; other site
866777005674	ABC transporter signature motif; other site
866777005675	Walker B; other site
866777005676	D-loop; other site
866777005677	H-loop/switch region; other site
866777005678	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
866777005679	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866777005680	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
866777005681	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
866777005682	substrate binding site; other site
866777005683	tetramer interface; other site
866777005684	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
866777005685	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
866777005686	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
866777005687	NADP binding site [chemical binding]; other site
866777005688	active site
866777005689	putative substrate binding site [chemical binding]; other site
866777005690	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
866777005691	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
866777005692	NAD binding site [chemical binding]; other site
866777005693	substrate binding site [chemical binding]; other site
866777005694	homodimer interface [polypeptide binding]; other site
866777005695	active site
866777005696	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
866777005697	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
866777005698	Ligand binding site; other site
866777005699	Putative Catalytic site; other site
866777005700	DXD motif; other site
866777005701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
866777005702	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866777005703	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
866777005704	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
866777005705	active site
866777005706	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866777005707	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866777005708	FtsX-like permease family; Region: FtsX; pfam02687
866777005709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777005710	ABC transporter; Region: ABC_tran; pfam00005
866777005711	Q-loop/lid; other site
866777005712	ABC transporter signature motif; other site
866777005713	Walker B; other site
866777005714	D-loop; other site
866777005715	H-loop/switch region; other site
866777005716	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866777005717	Zn2+ binding site [ion binding]; other site
866777005718	Mg2+ binding site [ion binding]; other site
866777005719	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
866777005720	putative active site [active]
866777005721	putative dimer interface [polypeptide binding]; other site
866777005722	K+ potassium transporter; Region: K_trans; pfam02705
866777005723	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866777005724	active site
866777005725	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866777005726	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777005727	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
866777005728	Walker A/P-loop; other site
866777005729	ATP binding site [chemical binding]; other site
866777005730	Q-loop/lid; other site
866777005731	ABC transporter signature motif; other site
866777005732	Walker B; other site
866777005733	D-loop; other site
866777005734	H-loop/switch region; other site
866777005735	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866777005736	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777005737	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777005738	Walker A/P-loop; other site
866777005739	ATP binding site [chemical binding]; other site
866777005740	Q-loop/lid; other site
866777005741	ABC transporter signature motif; other site
866777005742	Walker B; other site
866777005743	D-loop; other site
866777005744	H-loop/switch region; other site
866777005745	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
866777005746	AAA domain; Region: AAA_14; pfam13173
866777005747	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
866777005748	putative substrate binding site [chemical binding]; other site
866777005749	active site
866777005750	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777005751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005752	dimer interface [polypeptide binding]; other site
866777005753	conserved gate region; other site
866777005754	putative PBP binding loops; other site
866777005755	ABC-ATPase subunit interface; other site
866777005756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005757	dimer interface [polypeptide binding]; other site
866777005758	conserved gate region; other site
866777005759	putative PBP binding loops; other site
866777005760	ABC-ATPase subunit interface; other site
866777005761	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866777005762	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777005763	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005764	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777005765	DNA binding site [nucleotide binding]
866777005766	domain linker motif; other site
866777005767	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005768	ligand binding site [chemical binding]; other site
866777005769	dimerization interface [polypeptide binding]; other site
866777005770	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
866777005771	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
866777005772	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
866777005773	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
866777005774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866777005775	Walker A motif; other site
866777005776	ATP binding site [chemical binding]; other site
866777005777	Walker B motif; other site
866777005778	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
866777005779	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
866777005780	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866777005781	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
866777005782	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777005783	Walker A/P-loop; other site
866777005784	ATP binding site [chemical binding]; other site
866777005785	Q-loop/lid; other site
866777005786	ABC transporter signature motif; other site
866777005787	Walker B; other site
866777005788	D-loop; other site
866777005789	H-loop/switch region; other site
866777005790	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
866777005791	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866777005792	Walker A/P-loop; other site
866777005793	ATP binding site [chemical binding]; other site
866777005794	Q-loop/lid; other site
866777005795	ABC transporter signature motif; other site
866777005796	Walker B; other site
866777005797	D-loop; other site
866777005798	H-loop/switch region; other site
866777005799	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866777005800	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866777005801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005802	dimer interface [polypeptide binding]; other site
866777005803	conserved gate region; other site
866777005804	putative PBP binding loops; other site
866777005805	ABC-ATPase subunit interface; other site
866777005806	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866777005807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005808	dimer interface [polypeptide binding]; other site
866777005809	conserved gate region; other site
866777005810	putative PBP binding loops; other site
866777005811	ABC-ATPase subunit interface; other site
866777005812	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
866777005813	trimer interface [polypeptide binding]; other site
866777005814	active site
866777005815	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
866777005816	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
866777005817	active site
866777005818	HIGH motif; other site
866777005819	KMSKS motif; other site
866777005820	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
866777005821	tRNA binding surface [nucleotide binding]; other site
866777005822	anticodon binding site; other site
866777005823	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
866777005824	Predicted methyltransferases [General function prediction only]; Region: COG0313
866777005825	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
866777005826	putative SAM binding site [chemical binding]; other site
866777005827	putative homodimer interface [polypeptide binding]; other site
866777005828	MFS/sugar transport protein; Region: MFS_2; pfam13347
866777005829	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
866777005830	ApbE family; Region: ApbE; pfam02424
866777005831	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866777005832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777005833	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866777005834	Walker A/P-loop; other site
866777005835	ATP binding site [chemical binding]; other site
866777005836	Q-loop/lid; other site
866777005837	ABC transporter signature motif; other site
866777005838	Walker B; other site
866777005839	D-loop; other site
866777005840	H-loop/switch region; other site
866777005841	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866777005842	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866777005843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866777005844	Walker A/P-loop; other site
866777005845	ATP binding site [chemical binding]; other site
866777005846	Q-loop/lid; other site
866777005847	ABC transporter signature motif; other site
866777005848	Walker B; other site
866777005849	D-loop; other site
866777005850	H-loop/switch region; other site
866777005851	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
866777005852	FtsX-like permease family; Region: FtsX; pfam02687
866777005853	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866777005854	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866777005855	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866777005856	Walker A/P-loop; other site
866777005857	ATP binding site [chemical binding]; other site
866777005858	Q-loop/lid; other site
866777005859	ABC transporter signature motif; other site
866777005860	Walker B; other site
866777005861	D-loop; other site
866777005862	H-loop/switch region; other site
866777005863	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
866777005864	Protein of unknown function, DUF624; Region: DUF624; pfam04854
866777005865	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777005866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005867	dimer interface [polypeptide binding]; other site
866777005868	conserved gate region; other site
866777005869	putative PBP binding loops; other site
866777005870	ABC-ATPase subunit interface; other site
866777005871	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
866777005872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005873	putative PBP binding loops; other site
866777005874	dimer interface [polypeptide binding]; other site
866777005875	ABC-ATPase subunit interface; other site
866777005876	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005877	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777005878	DNA binding site [nucleotide binding]
866777005879	domain linker motif; other site
866777005880	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005881	ligand binding site [chemical binding]; other site
866777005882	dimerization interface [polypeptide binding]; other site
866777005883	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866777005884	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777005885	catalytic core [active]
866777005886	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866777005887	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
866777005888	Predicted membrane protein [Function unknown]; Region: COG1511
866777005889	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
866777005890	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
866777005891	Predicted membrane protein [Function unknown]; Region: COG1511
866777005892	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
866777005893	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
866777005894	unresolved repeat; rRNA operon with unverified consensus
866777005895	unresolved repeat; rRNA operon with unverified consensus
866777005896	NAD-dependent deacetylase; Provisional; Region: PRK00481
866777005897	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
866777005898	threonine dehydratase; Provisional; Region: PRK08198
866777005899	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
866777005900	tetramer interface [polypeptide binding]; other site
866777005901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866777005902	catalytic residue [active]
866777005903	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
866777005904	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
866777005905	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866777005906	Ca binding site [ion binding]; other site
866777005907	active site
866777005908	catalytic site [active]
866777005909	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866777005910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005911	dimer interface [polypeptide binding]; other site
866777005912	conserved gate region; other site
866777005913	putative PBP binding loops; other site
866777005914	ABC-ATPase subunit interface; other site
866777005915	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866777005916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866777005917	dimer interface [polypeptide binding]; other site
866777005918	conserved gate region; other site
866777005919	putative PBP binding loops; other site
866777005920	ABC-ATPase subunit interface; other site
866777005921	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866777005922	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866777005923	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866777005924	MarR family; Region: MarR_2; pfam12802
866777005925	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866777005926	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866777005927	nucleotide binding site [chemical binding]; other site
866777005928	Melibiase; Region: Melibiase; pfam02065
866777005929	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
866777005930	nucleoside/Zn binding site; other site
866777005931	dimer interface [polypeptide binding]; other site
866777005932	catalytic motif [active]
866777005933	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
866777005934	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866777005935	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
866777005936	Serine hydrolase (FSH1); Region: FSH1; pfam03959
866777005937	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
866777005938	trimer interface [polypeptide binding]; other site
866777005939	active site
866777005940	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
866777005941	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
866777005942	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866777005943	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
866777005944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866777005945	active site
866777005946	motif I; other site
866777005947	motif II; other site
866777005948	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866777005949	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005950	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866777005951	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866777005952	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866777005953	putative substrate translocation pore; other site
866777005954	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
866777005955	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
866777005956	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866777005957	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
866777005958	active site
866777005959	phosphate binding residues; other site
866777005960	catalytic residues [active]
866777005961	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
866777005962	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
866777005963	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
866777005964	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
866777005965	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
866777005966	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866777005967	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866777005968	DNA binding site [nucleotide binding]
866777005969	domain linker motif; other site
866777005970	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866777005971	ligand binding site [chemical binding]; other site
866777005972	dimerization interface [polypeptide binding]; other site
866777005973	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
866777005974	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
866777005975	putative ligand binding site [chemical binding]; other site
866777005976	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
866777005977	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866777005978	Walker A/P-loop; other site
866777005979	ATP binding site [chemical binding]; other site
866777005980	Q-loop/lid; other site
866777005981	ABC transporter signature motif; other site
866777005982	Walker B; other site
866777005983	D-loop; other site
866777005984	H-loop/switch region; other site
866777005985	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866777005986	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866777005987	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866777005988	TM-ABC transporter signature motif; other site
866777005989	Homeodomain-like domain; Region: HTH_23; pfam13384
866777005990	Homeodomain-like domain; Region: HTH_32; pfam13565
866777005991	putative transposase OrfB; Reviewed; Region: PHA02517
866777005992	Integrase core domain; Region: rve; pfam00665
866777005993	Integrase core domain; Region: rve_3; pfam13683
866777005994	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
866777005995	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
866777005996	Walker A/P-loop; other site
866777005997	ATP binding site [chemical binding]; other site
866777005998	Q-loop/lid; other site
866777005999	ABC transporter signature motif; other site
866777006000	Walker B; other site
866777006001	D-loop; other site
866777006002	H-loop/switch region; other site
866777006003	TOBE domain; Region: TOBE_2; pfam08402
866777006004	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866777006005	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866777006006	DNA-binding site [nucleotide binding]; DNA binding site
866777006007	UTRA domain; Region: UTRA; pfam07702
866777006008	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
866777006009	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866777006010	active site
866777006011	P-loop; other site
866777006012	phosphorylation site [posttranslational modification]
866777006013	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866777006014	active site
866777006015	phosphorylation site [posttranslational modification]
866777006016	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
866777006017	active site
866777006018	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
866777006019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866777006020	active site
866777006021	phosphorylation site [posttranslational modification]
866777006022	intermolecular recognition site; other site
866777006023	dimerization interface [polypeptide binding]; other site
866777006024	LytTr DNA-binding domain; Region: LytTR; smart00850
866777006025	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
866777006026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866777006027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866777006028	ATP binding site [chemical binding]; other site
866777006029	Mg2+ binding site [ion binding]; other site
866777006030	G-X-G motif; other site
866777006031	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
866777006032	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
866777006033	dimer interface [polypeptide binding]; other site
866777006034	putative radical transfer pathway; other site
866777006035	diiron center [ion binding]; other site
866777006036	tyrosyl radical; other site
866777006037	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
866777006038	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
866777006039	Class I ribonucleotide reductase; Region: RNR_I; cd01679
866777006040	active site
866777006041	dimer interface [polypeptide binding]; other site
866777006042	catalytic residues [active]
866777006043	effector binding site; other site
866777006044	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866777006045	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
866777006046	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
866777006047	catalytic residues [active]
866777006048	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
866777006049	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866777006050	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
866777006051	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
866777006052	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866777006053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866777006054	non-specific DNA binding site [nucleotide binding]; other site
866777006055	salt bridge; other site
866777006056	sequence-specific DNA binding site [nucleotide binding]; other site
866777006057	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
866777006058	Ion channel; Region: Ion_trans_2; pfam07885
866777006059	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
866777006060	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
866777006061	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
866777006062	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866777006063	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
866777006064	Catalytic domain of Protein Kinases; Region: PKc; cd00180
866777006065	active site
866777006066	ATP binding site [chemical binding]; other site
866777006067	substrate binding site [chemical binding]; other site
866777006068	activation loop (A-loop); other site
866777006069	Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227
866777006070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
866777006071	Domain of unknown function (DUF348); Region: DUF348; pfam03990
866777006072	Domain of unknown function (DUF348); Region: DUF348; pfam03990
866777006073	G5 domain; Region: G5; pfam07501
866777006074	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866777006075	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866777006076	catalytic residue [active]
866777006077	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
866777006078	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
866777006079	S-adenosylmethionine binding site [chemical binding]; other site
866777006080	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
866777006081	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866777006082	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866777006083	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
866777006084	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
866777006085	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
866777006086	active site
866777006087	NTP binding site [chemical binding]; other site
866777006088	metal binding triad [ion binding]; metal-binding site
866777006089	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
866777006090	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866777006091	Zn2+ binding site [ion binding]; other site
866777006092	Mg2+ binding site [ion binding]; other site
866777006093	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
866777006094	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
866777006095	active site
866777006096	Ap6A binding site [chemical binding]; other site
866777006097	nudix motif; other site
866777006098	metal binding site [ion binding]; metal-binding site
866777006099	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
866777006100	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
866777006101	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
866777006102	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866777006103	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866777006104	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
866777006105	ParB-like nuclease domain; Region: ParB; smart00470
866777006106	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
866777006107	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866777006108	P-loop; other site
866777006109	Magnesium ion binding site [ion binding]; other site
866777006110	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866777006111	Magnesium ion binding site [ion binding]; other site
866777006112	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
866777006113	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
866777006114	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
866777006115	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
866777006116	G-X-X-G motif; other site
866777006117	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
866777006118	RxxxH motif; other site
866777006119	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
866777006120	Ribonuclease P; Region: Ribonuclease_P; pfam00825
866777006121	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399