-- dump date 20140619_001054 -- class Genbank::misc_feature -- table misc_feature_note -- id note 283165000001 PEP synthetase regulatory protein; Provisional; Region: PRK05339 283165000002 Maf-like protein; Region: Maf; pfam02545 283165000003 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 283165000004 active site 283165000005 dimer interface [polypeptide binding]; other site 283165000006 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 283165000007 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 283165000008 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 283165000009 shikimate binding site; other site 283165000010 NAD(P) binding site [chemical binding]; other site 283165000011 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 283165000012 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 283165000013 CoA-binding site [chemical binding]; other site 283165000014 ATP-binding [chemical binding]; other site 283165000015 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 283165000016 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 283165000017 active site 283165000018 catalytic site [active] 283165000019 substrate binding site [chemical binding]; other site 283165000020 DNA polymerase I; Region: pola; TIGR00593 283165000021 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 283165000022 active site 283165000023 metal binding site 1 [ion binding]; metal-binding site 283165000024 putative 5' ssDNA interaction site; other site 283165000025 metal binding site 3; metal-binding site 283165000026 metal binding site 2 [ion binding]; metal-binding site 283165000027 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 283165000028 putative DNA binding site [nucleotide binding]; other site 283165000029 putative metal binding site [ion binding]; other site 283165000030 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 283165000031 active site 283165000032 catalytic site [active] 283165000033 substrate binding site [chemical binding]; other site 283165000034 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 283165000035 active site 283165000036 DNA binding site [nucleotide binding] 283165000037 catalytic site [active] 283165000038 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 283165000039 putative catalytic site [active] 283165000040 putative metal binding site [ion binding]; other site 283165000041 putative phosphate binding site [ion binding]; other site 283165000042 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 283165000043 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 283165000044 lipoprotein signal peptidase; Provisional; Region: PRK14795 283165000045 lipoprotein signal peptidase; Provisional; Region: PRK14787 283165000046 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 283165000047 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 283165000048 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 283165000049 Identified by comparison to Bartonella henselae;sam dependent methyltransferas 283165000050 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 283165000051 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 283165000052 IHF dimer interface [polypeptide binding]; other site 283165000053 IHF - DNA interface [nucleotide binding]; other site 283165000054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 283165000055 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 283165000056 OstA-like protein; Region: OstA; pfam03968 283165000057 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 283165000058 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 283165000059 Walker A/P-loop; other site 283165000060 ATP binding site [chemical binding]; other site 283165000061 Q-loop/lid; other site 283165000062 ABC transporter signature motif; other site 283165000063 Walker B; other site 283165000064 D-loop; other site 283165000065 H-loop/switch region; other site 283165000066 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 283165000067 active site 283165000068 phosphorylation site [posttranslational modification] 283165000069 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 283165000070 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 283165000071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 283165000072 FeS/SAM binding site; other site 283165000073 Identified by comparison to Brucella melitensis;homoserine/homoserine lactone efflux protein 283165000074 Identified by comparison to Brucella melitensis;argininosuccinate synthase 283165000075 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 283165000076 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 283165000077 active site 283165000078 nucleotide binding site [chemical binding]; other site 283165000079 HIGH motif; other site 283165000080 KMSKS motif; other site 283165000081 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 283165000082 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 283165000083 G1 box; other site 283165000084 putative GEF interaction site [polypeptide binding]; other site 283165000085 GTP/Mg2+ binding site [chemical binding]; other site 283165000086 Switch I region; other site 283165000087 G2 box; other site 283165000088 G3 box; other site 283165000089 Switch II region; other site 283165000090 G4 box; other site 283165000091 G5 box; other site 283165000092 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 283165000093 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 283165000094 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 283165000095 catalytic residues [active] 283165000096 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 283165000097 Part of AAA domain; Region: AAA_19; pfam13245 283165000098 Family description; Region: UvrD_C_2; pfam13538 283165000099 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 283165000100 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 283165000101 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 283165000102 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 283165000103 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 283165000104 Phosphotransferase enzyme family; Region: APH; pfam01636 283165000105 PAS domain; Region: PAS_8; pfam13188 283165000106 PAS fold; Region: PAS_7; pfam12860 283165000107 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 283165000108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165000109 dimer interface [polypeptide binding]; other site 283165000110 phosphorylation site [posttranslational modification] 283165000111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165000112 ATP binding site [chemical binding]; other site 283165000113 Mg2+ binding site [ion binding]; other site 283165000114 G-X-G motif; other site 283165000115 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 283165000116 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 283165000117 homotetramer interface [polypeptide binding]; other site 283165000118 ligand binding site [chemical binding]; other site 283165000119 catalytic site [active] 283165000120 NAD binding site [chemical binding]; other site 283165000121 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 283165000122 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 283165000123 putative NAD(P) binding site [chemical binding]; other site 283165000124 active site 283165000125 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 283165000126 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 283165000127 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 283165000128 Identified by comparison to Bartonella henselae;hypothetical protein 283165000129 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 283165000130 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 283165000131 Flavoprotein; Region: Flavoprotein; pfam02441 283165000132 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 283165000133 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 283165000134 ABC1 family; Region: ABC1; cl17513 283165000135 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 283165000136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165000137 S-adenosylmethionine binding site [chemical binding]; other site 283165000138 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 283165000139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165000140 Mg2+ binding site [ion binding]; other site 283165000141 G-X-G motif; other site 283165000142 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 283165000143 anchoring element; other site 283165000144 dimer interface [polypeptide binding]; other site 283165000145 ATP binding site [chemical binding]; other site 283165000146 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 283165000147 active site 283165000148 putative metal-binding site [ion binding]; other site 283165000149 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 283165000150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 283165000151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 283165000152 substrate binding pocket [chemical binding]; other site 283165000153 membrane-bound complex binding site; other site 283165000154 hinge residues; other site 283165000155 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 283165000156 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 283165000157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165000158 Walker A motif; other site 283165000159 ATP binding site [chemical binding]; other site 283165000160 Walker B motif; other site 283165000161 arginine finger; other site 283165000162 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 283165000163 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 283165000164 Surface antigen; Region: Bac_surface_Ag; pfam01103 283165000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 283165000166 Family of unknown function (DUF490); Region: DUF490; pfam04357 283165000167 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 283165000168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 283165000169 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 283165000170 Walker A/P-loop; other site 283165000171 ATP binding site [chemical binding]; other site 283165000172 Q-loop/lid; other site 283165000173 ABC transporter signature motif; other site 283165000174 Walker B; other site 283165000175 D-loop; other site 283165000176 H-loop/switch region; other site 283165000177 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 283165000178 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 283165000179 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 283165000180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 283165000181 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 283165000182 catalytic site [active] 283165000183 Protein of unknown function DUF45; Region: DUF45; pfam01863 283165000184 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 283165000185 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 283165000186 metal binding site [ion binding]; metal-binding site 283165000187 dimer interface [polypeptide binding]; other site 283165000188 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 283165000189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 283165000190 FeS/SAM binding site; other site 283165000191 HemN C-terminal domain; Region: HemN_C; pfam06969 283165000192 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 283165000193 active site 283165000194 dimerization interface [polypeptide binding]; other site 283165000195 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 283165000196 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 283165000197 heat shock protein GrpE; Provisional; Region: PRK14141 283165000198 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 283165000199 dimer interface [polypeptide binding]; other site 283165000200 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 283165000201 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 283165000202 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 283165000203 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 283165000204 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 283165000205 dimerization domain swap beta strand [polypeptide binding]; other site 283165000206 regulatory protein interface [polypeptide binding]; other site 283165000207 active site 283165000208 regulatory phosphorylation site [posttranslational modification]; other site 283165000209 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 283165000210 active pocket/dimerization site; other site 283165000211 active site 283165000212 phosphorylation site [posttranslational modification] 283165000213 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 283165000214 Hpr binding site; other site 283165000215 active site 283165000216 homohexamer subunit interaction site [polypeptide binding]; other site 283165000217 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 283165000218 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 283165000219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165000220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 283165000221 dimerization interface [polypeptide binding]; other site 283165000222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165000223 dimer interface [polypeptide binding]; other site 283165000224 phosphorylation site [posttranslational modification] 283165000225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165000226 ATP binding site [chemical binding]; other site 283165000227 Mg2+ binding site [ion binding]; other site 283165000228 G-X-G motif; other site 283165000229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 283165000230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165000231 active site 283165000232 phosphorylation site [posttranslational modification] 283165000233 intermolecular recognition site; other site 283165000234 dimerization interface [polypeptide binding]; other site 283165000235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 283165000236 DNA binding site [nucleotide binding] 283165000237 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 283165000238 BON domain; Region: BON; pfam04972 283165000239 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 283165000240 Protein of unknown function (DUF461); Region: DUF461; pfam04314 283165000241 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 283165000242 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 283165000243 nucleotide binding site [chemical binding]; other site 283165000244 NEF interaction site [polypeptide binding]; other site 283165000245 SBD interface [polypeptide binding]; other site 283165000246 chaperone protein DnaJ; Provisional; Region: PRK10767 283165000247 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 283165000248 HSP70 interaction site [polypeptide binding]; other site 283165000249 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 283165000250 substrate binding site [polypeptide binding]; other site 283165000251 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 283165000252 Zn binding sites [ion binding]; other site 283165000253 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 283165000254 dimer interface [polypeptide binding]; other site 283165000255 Identified by comparison to Bartonella henselae;prophage integrase 283165000256 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 283165000257 homohexameric interface [polypeptide binding]; other site 283165000258 feedback inhibition sensing region; other site 283165000259 nucleotide binding site [chemical binding]; other site 283165000260 N-acetyl-L-glutamate binding site [chemical binding]; other site 283165000261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 283165000262 EamA-like transporter family; Region: EamA; pfam00892 283165000263 GTP-binding protein LepA; Provisional; Region: PRK05433 283165000264 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 283165000265 G1 box; other site 283165000266 putative GEF interaction site [polypeptide binding]; other site 283165000267 GTP/Mg2+ binding site [chemical binding]; other site 283165000268 Switch I region; other site 283165000269 G2 box; other site 283165000270 G3 box; other site 283165000271 Switch II region; other site 283165000272 G4 box; other site 283165000273 G5 box; other site 283165000274 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 283165000275 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 283165000276 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 283165000277 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 283165000278 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 283165000279 trimer interface [polypeptide binding]; other site 283165000280 active site 283165000281 substrate binding site [chemical binding]; other site 283165000282 CoA binding site [chemical binding]; other site 283165000283 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 283165000284 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 283165000285 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 283165000286 dimerization interface 3.5A [polypeptide binding]; other site 283165000287 active site 283165000288 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 283165000289 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 283165000290 putative active site [active] 283165000291 substrate binding site [chemical binding]; other site 283165000292 putative cosubstrate binding site; other site 283165000293 catalytic site [active] 283165000294 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 283165000295 substrate binding site [chemical binding]; other site 283165000296 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 283165000297 active site 283165000298 catalytic residues [active] 283165000299 metal binding site [ion binding]; metal-binding site 283165000300 RmuC family; Region: RmuC; pfam02646 283165000301 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 283165000302 N-acetyl-D-glucosamine binding site [chemical binding]; other site 283165000303 catalytic residue [active] 283165000304 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 283165000305 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 283165000306 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 283165000307 putative dimer interface [polypeptide binding]; other site 283165000308 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 283165000309 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 283165000310 minor groove reading motif; other site 283165000311 helix-hairpin-helix signature motif; other site 283165000312 substrate binding pocket [chemical binding]; other site 283165000313 active site 283165000314 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 283165000315 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 283165000316 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 283165000317 23S rRNA binding site [nucleotide binding]; other site 283165000318 L21 binding site [polypeptide binding]; other site 283165000319 L13 binding site [polypeptide binding]; other site 283165000320 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 283165000321 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 283165000322 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 283165000323 dimer interface [polypeptide binding]; other site 283165000324 motif 1; other site 283165000325 active site 283165000326 motif 2; other site 283165000327 motif 3; other site 283165000328 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 283165000329 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 283165000330 putative tRNA-binding site [nucleotide binding]; other site 283165000331 B3/4 domain; Region: B3_4; pfam03483 283165000332 tRNA synthetase B5 domain; Region: B5; smart00874 283165000333 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 283165000334 dimer interface [polypeptide binding]; other site 283165000335 motif 1; other site 283165000336 motif 3; other site 283165000337 motif 2; other site 283165000338 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 283165000339 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 283165000340 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 283165000341 metal binding site [ion binding]; metal-binding site 283165000342 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 283165000343 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 283165000344 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 283165000345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 283165000346 ABC-ATPase subunit interface; other site 283165000347 dimer interface [polypeptide binding]; other site 283165000348 putative PBP binding regions; other site 283165000349 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 283165000350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 283165000351 ABC-ATPase subunit interface; other site 283165000352 dimer interface [polypeptide binding]; other site 283165000353 putative PBP binding regions; other site 283165000354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 283165000355 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 283165000356 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 283165000357 active site 283165000358 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 283165000359 Putative glucoamylase; Region: Glycoamylase; pfam10091 283165000360 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 283165000361 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 283165000362 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 283165000363 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 283165000364 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 283165000365 RNA binding site [nucleotide binding]; other site 283165000366 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 283165000367 RNA binding site [nucleotide binding]; other site 283165000368 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 283165000369 RNA binding site [nucleotide binding]; other site 283165000370 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 283165000371 RNA binding site [nucleotide binding]; other site 283165000372 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 283165000373 RNA binding site [nucleotide binding]; other site 283165000374 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 283165000375 RNA binding site [nucleotide binding]; other site 283165000376 cytidylate kinase; Provisional; Region: cmk; PRK00023 283165000377 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 283165000378 CMP-binding site; other site 283165000379 The sites determining sugar specificity; other site 283165000380 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 283165000381 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 283165000382 hinge; other site 283165000383 active site 283165000384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 283165000385 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 283165000386 Identified by comparison to Bartonella henselae;ilvd 283165000387 Identified by comparison to Mesorhizobium loti;transposase 283165000388 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 283165000389 MutS domain I; Region: MutS_I; pfam01624 283165000390 MutS domain II; Region: MutS_II; pfam05188 283165000391 MutS domain III; Region: MutS_III; pfam05192 283165000392 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 283165000393 Walker A/P-loop; other site 283165000394 ATP binding site [chemical binding]; other site 283165000395 Q-loop/lid; other site 283165000396 ABC transporter signature motif; other site 283165000397 Walker B; other site 283165000398 D-loop; other site 283165000399 H-loop/switch region; other site 283165000400 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 283165000401 Malic enzyme, N-terminal domain; Region: malic; pfam00390 283165000402 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 283165000403 putative NAD(P) binding site [chemical binding]; other site 283165000404 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 283165000405 preprotein translocase subunit SecB; Validated; Region: PRK05751 283165000406 SecA binding site; other site 283165000407 Preprotein binding site; other site 283165000408 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 283165000409 Tim44-like domain; Region: Tim44; pfam04280 283165000410 Identified by comparison to Bartonella henselae;hypothetical protein 283165000411 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 283165000412 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 283165000413 dimerization interface [polypeptide binding]; other site 283165000414 domain crossover interface; other site 283165000415 redox-dependent activation switch; other site 283165000416 Identified by comparison to Brucella melitensis;ornithine carbamoyltransferase 283165000417 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 283165000418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 283165000419 inhibitor-cofactor binding pocket; inhibition site 283165000420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 283165000421 catalytic residue [active] 283165000422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 283165000423 Identified by comparison to Brucella melitensis;transposase 283165000424 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 283165000425 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 283165000426 catalytic residues [active] 283165000427 central insert; other site 283165000428 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 283165000429 heme exporter protein CcmC; Region: ccmC; TIGR01191 283165000430 heme exporter protein CcmB; Region: ccmB; TIGR01190 283165000431 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 283165000432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 283165000433 Walker A/P-loop; other site 283165000434 ATP binding site [chemical binding]; other site 283165000435 Q-loop/lid; other site 283165000436 ABC transporter signature motif; other site 283165000437 Walker B; other site 283165000438 D-loop; other site 283165000439 H-loop/switch region; other site 283165000440 aconitate hydratase; Validated; Region: PRK09277 283165000441 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 283165000442 substrate binding site [chemical binding]; other site 283165000443 ligand binding site [chemical binding]; other site 283165000444 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 283165000445 substrate binding site [chemical binding]; other site 283165000446 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 283165000447 DnaA N-terminal domain; Region: DnaA_N; pfam11638 283165000448 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 283165000449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 283165000450 Walker A motif; other site 283165000451 ATP binding site [chemical binding]; other site 283165000452 Walker B motif; other site 283165000453 arginine finger; other site 283165000454 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 283165000455 DnaA box-binding interface [nucleotide binding]; other site 283165000456 DNA polymerase III subunit beta; Validated; Region: PRK05643 283165000457 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 283165000458 putative DNA binding surface [nucleotide binding]; other site 283165000459 dimer interface [polypeptide binding]; other site 283165000460 beta-clamp/clamp loader binding surface; other site 283165000461 beta-clamp/translesion DNA polymerase binding surface; other site 283165000462 recombination protein F; Reviewed; Region: recF; PRK00064 283165000463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 283165000464 Walker A/P-loop; other site 283165000465 ATP binding site [chemical binding]; other site 283165000466 Q-loop/lid; other site 283165000467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 283165000468 ABC transporter signature motif; other site 283165000469 Walker B; other site 283165000470 D-loop; other site 283165000471 H-loop/switch region; other site 283165000472 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 283165000473 Dehydroquinase class II; Region: DHquinase_II; pfam01220 283165000474 trimer interface [polypeptide binding]; other site 283165000475 active site 283165000476 dimer interface [polypeptide binding]; other site 283165000477 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 283165000478 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 283165000479 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 283165000480 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 283165000481 D-pathway; other site 283165000482 Putative ubiquinol binding site [chemical binding]; other site 283165000483 Low-spin heme (heme b) binding site [chemical binding]; other site 283165000484 Putative water exit pathway; other site 283165000485 Binuclear center (heme o3/CuB) [ion binding]; other site 283165000486 K-pathway; other site 283165000487 Putative proton exit pathway; other site 283165000488 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 283165000489 Subunit I/III interface [polypeptide binding]; other site 283165000490 Subunit III/IV interface [polypeptide binding]; other site 283165000491 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 283165000492 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 283165000493 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 283165000494 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 283165000495 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 283165000496 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 283165000497 NAD binding site [chemical binding]; other site 283165000498 homotetramer interface [polypeptide binding]; other site 283165000499 homodimer interface [polypeptide binding]; other site 283165000500 substrate binding site [chemical binding]; other site 283165000501 active site 283165000502 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 283165000503 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 283165000504 dimer interface [polypeptide binding]; other site 283165000505 active site 283165000506 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 283165000507 active site 1 [active] 283165000508 dimer interface [polypeptide binding]; other site 283165000509 active site 2 [active] 283165000510 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 283165000511 metal binding site 2 [ion binding]; metal-binding site 283165000512 putative DNA binding helix; other site 283165000513 metal binding site 1 [ion binding]; metal-binding site 283165000514 dimer interface [polypeptide binding]; other site 283165000515 structural Zn2+ binding site [ion binding]; other site 283165000516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 283165000517 Bacterial SH3 domain; Region: SH3_4; pfam06347 283165000518 Bacterial SH3 domain; Region: SH3_4; pfam06347 283165000519 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 283165000520 Identified by comparison to Mesorhizobium loti;formate-tetrahydrofolate ligase 283165000521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 283165000522 HlyD family secretion protein; Region: HlyD_3; pfam13437 283165000523 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 283165000524 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 283165000525 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 283165000526 active site 283165000527 dimer interface [polypeptide binding]; other site 283165000528 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 283165000529 dimer interface [polypeptide binding]; other site 283165000530 active site 283165000531 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 283165000532 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 283165000533 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 283165000534 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 283165000535 active site 283165000536 phosphorylation site [posttranslational modification] 283165000537 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 283165000538 dimerization domain swap beta strand [polypeptide binding]; other site 283165000539 regulatory protein interface [polypeptide binding]; other site 283165000540 active site 283165000541 regulatory phosphorylation site [posttranslational modification]; other site 283165000542 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 283165000543 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 283165000544 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 283165000545 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 283165000546 Identified by comparison to Bartonella henselae;hypothetical protein 283165000547 Identified by comparison to Bartonella henselae;hypothetical protein 283165000548 YadA-like C-terminal region; Region: YadA; pfam03895 283165000549 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 283165000550 trimer interface [polypeptide binding]; other site 283165000551 Haemagglutinin; Region: HIM; pfam05662 283165000552 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 283165000553 YadA-like C-terminal region; Region: YadA; pfam03895 283165000554 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 283165000555 YadA-like C-terminal region; Region: YadA; pfam03895 283165000556 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 283165000557 Identified by comparison to Bartonella henselae;exopolyphosphatase 283165000558 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 283165000559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165000560 S-adenosylmethionine binding site [chemical binding]; other site 283165000561 GTPase CgtA; Reviewed; Region: obgE; PRK12299 283165000562 GTP1/OBG; Region: GTP1_OBG; pfam01018 283165000563 Obg GTPase; Region: Obg; cd01898 283165000564 G1 box; other site 283165000565 GTP/Mg2+ binding site [chemical binding]; other site 283165000566 Switch I region; other site 283165000567 G2 box; other site 283165000568 G3 box; other site 283165000569 Switch II region; other site 283165000570 G4 box; other site 283165000571 G5 box; other site 283165000572 gamma-glutamyl kinase; Provisional; Region: PRK05429 283165000573 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 283165000574 nucleotide binding site [chemical binding]; other site 283165000575 homotetrameric interface [polypeptide binding]; other site 283165000576 putative phosphate binding site [ion binding]; other site 283165000577 putative allosteric binding site; other site 283165000578 PUA domain; Region: PUA; pfam01472 283165000579 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 283165000580 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 283165000581 putative catalytic cysteine [active] 283165000582 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 283165000583 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 283165000584 active site 283165000585 (T/H)XGH motif; other site 283165000586 Identified by comparison to Bartonella henselae;hypothetical protein 283165000587 Identified by comparison to Bartonella henselae;hypothetical protein 283165000588 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 283165000589 Peptidase family M23; Region: Peptidase_M23; pfam01551 283165000590 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 283165000591 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 283165000592 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 283165000593 protein binding site [polypeptide binding]; other site 283165000594 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 283165000595 Catalytic dyad [active] 283165000596 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 283165000597 putative active site [active] 283165000598 Ap4A binding site [chemical binding]; other site 283165000599 nudix motif; other site 283165000600 putative metal binding site [ion binding]; other site 283165000601 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 283165000602 YGGT family; Region: YGGT; pfam02325 283165000603 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 283165000604 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 283165000605 dimer interface [polypeptide binding]; other site 283165000606 substrate binding site [chemical binding]; other site 283165000607 metal binding sites [ion binding]; metal-binding site 283165000608 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 283165000609 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 283165000610 G1 box; other site 283165000611 putative GEF interaction site [polypeptide binding]; other site 283165000612 GTP/Mg2+ binding site [chemical binding]; other site 283165000613 Switch I region; other site 283165000614 G2 box; other site 283165000615 G3 box; other site 283165000616 Switch II region; other site 283165000617 G4 box; other site 283165000618 G5 box; other site 283165000619 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 283165000620 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 283165000621 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 283165000622 MgtE intracellular N domain; Region: MgtE_N; pfam03448 283165000623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 283165000624 Divalent cation transporter; Region: MgtE; pfam01769 283165000625 Identified by comparison to Bartonella henselae;peptidyl-dipeptidase dcp 283165000626 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 283165000627 active site 283165000628 catalytic triad [active] 283165000629 oxyanion hole [active] 283165000630 Transglycosylase SLT domain; Region: SLT_2; pfam13406 283165000631 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 283165000632 N-acetyl-D-glucosamine binding site [chemical binding]; other site 283165000633 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 283165000634 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 283165000635 active site 283165000636 tetramer interface; other site 283165000637 KpsF/GutQ family protein; Region: kpsF; TIGR00393 283165000638 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 283165000639 putative active site [active] 283165000640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 283165000641 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 283165000642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165000643 active site 283165000644 phosphorylation site [posttranslational modification] 283165000645 intermolecular recognition site; other site 283165000646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165000647 Walker A motif; other site 283165000648 ATP binding site [chemical binding]; other site 283165000649 Walker B motif; other site 283165000650 arginine finger; other site 283165000651 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 283165000652 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 283165000653 PLD-like domain; Region: PLDc_2; pfam13091 283165000654 putative active site [active] 283165000655 catalytic site [active] 283165000656 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 283165000657 PLD-like domain; Region: PLDc_2; pfam13091 283165000658 putative active site [active] 283165000659 catalytic site [active] 283165000660 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 283165000661 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 283165000662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 283165000663 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 283165000664 active site 283165000665 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 283165000666 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 283165000667 GMP synthase; Reviewed; Region: guaA; PRK00074 283165000668 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 283165000669 AMP/PPi binding site [chemical binding]; other site 283165000670 candidate oxyanion hole; other site 283165000671 catalytic triad [active] 283165000672 potential glutamine specificity residues [chemical binding]; other site 283165000673 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 283165000674 ATP Binding subdomain [chemical binding]; other site 283165000675 Ligand Binding sites [chemical binding]; other site 283165000676 Dimerization subdomain; other site 283165000677 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 283165000678 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 283165000679 active site 283165000680 catalytic site [active] 283165000681 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 283165000682 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 283165000683 Walker A/P-loop; other site 283165000684 ATP binding site [chemical binding]; other site 283165000685 Q-loop/lid; other site 283165000686 ABC transporter signature motif; other site 283165000687 Walker B; other site 283165000688 D-loop; other site 283165000689 H-loop/switch region; other site 283165000690 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 283165000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165000692 dimer interface [polypeptide binding]; other site 283165000693 conserved gate region; other site 283165000694 putative PBP binding loops; other site 283165000695 ABC-ATPase subunit interface; other site 283165000696 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 283165000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165000698 dimer interface [polypeptide binding]; other site 283165000699 conserved gate region; other site 283165000700 putative PBP binding loops; other site 283165000701 ABC-ATPase subunit interface; other site 283165000702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 283165000703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 283165000704 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 283165000705 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 283165000706 metal binding site [ion binding]; metal-binding site 283165000707 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 283165000708 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 283165000709 ABC-ATPase subunit interface; other site 283165000710 dimer interface [polypeptide binding]; other site 283165000711 putative PBP binding regions; other site 283165000712 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 283165000713 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 283165000714 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 283165000715 catalytic residues [active] 283165000716 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 283165000717 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 283165000718 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 283165000719 Class I ribonucleotide reductase; Region: RNR_I; cd01679 283165000720 active site 283165000721 dimer interface [polypeptide binding]; other site 283165000722 catalytic residues [active] 283165000723 effector binding site; other site 283165000724 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 283165000725 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 283165000726 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 283165000727 dimer interface [polypeptide binding]; other site 283165000728 putative radical transfer pathway; other site 283165000729 diiron center [ion binding]; other site 283165000730 tyrosyl radical; other site 283165000731 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 283165000732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165000733 S-adenosylmethionine binding site [chemical binding]; other site 283165000734 peptide chain release factor 1; Validated; Region: prfA; PRK00591 283165000735 This domain is found in peptide chain release factors; Region: PCRF; smart00937 283165000736 RF-1 domain; Region: RF-1; pfam00472 283165000737 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 283165000738 metal binding site 2 [ion binding]; metal-binding site 283165000739 putative DNA binding helix; other site 283165000740 metal binding site 1 [ion binding]; metal-binding site 283165000741 dimer interface [polypeptide binding]; other site 283165000742 structural Zn2+ binding site [ion binding]; other site 283165000743 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 283165000744 DEAD/DEAH box helicase; Region: DEAD; pfam00270 283165000745 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 283165000746 SEC-C motif; Region: SEC-C; pfam02810 283165000747 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 283165000748 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 283165000749 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 283165000750 heterotetramer interface [polypeptide binding]; other site 283165000751 active site pocket [active] 283165000752 cleavage site 283165000753 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 283165000754 active site 283165000755 8-oxo-dGMP binding site [chemical binding]; other site 283165000756 nudix motif; other site 283165000757 metal binding site [ion binding]; metal-binding site 283165000758 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 283165000759 NlpC/P60 family; Region: NLPC_P60; cl17555 283165000760 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 283165000761 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 283165000762 interface (dimer of trimers) [polypeptide binding]; other site 283165000763 Substrate-binding/catalytic site; other site 283165000764 Zn-binding sites [ion binding]; other site 283165000765 pantothenate kinase; Provisional; Region: PRK05439 283165000766 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 283165000767 ATP-binding site [chemical binding]; other site 283165000768 CoA-binding site [chemical binding]; other site 283165000769 Mg2+-binding site [ion binding]; other site 283165000770 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 283165000771 active site 283165000772 homotetramer interface [polypeptide binding]; other site 283165000773 homodimer interface [polypeptide binding]; other site 283165000774 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 283165000775 active site 283165000776 HslU subunit interaction site [polypeptide binding]; other site 283165000777 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 283165000778 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 283165000779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165000780 Walker A motif; other site 283165000781 ATP binding site [chemical binding]; other site 283165000782 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 283165000783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 283165000784 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 283165000785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165000786 S-adenosylmethionine binding site [chemical binding]; other site 283165000787 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 283165000788 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 283165000789 RNase E interface [polypeptide binding]; other site 283165000790 trimer interface [polypeptide binding]; other site 283165000791 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 283165000792 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 283165000793 RNase E interface [polypeptide binding]; other site 283165000794 trimer interface [polypeptide binding]; other site 283165000795 active site 283165000796 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 283165000797 putative nucleic acid binding region [nucleotide binding]; other site 283165000798 G-X-X-G motif; other site 283165000799 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 283165000800 RNA binding site [nucleotide binding]; other site 283165000801 domain interface; other site 283165000802 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 283165000803 16S/18S rRNA binding site [nucleotide binding]; other site 283165000804 S13e-L30e interaction site [polypeptide binding]; other site 283165000805 25S rRNA binding site [nucleotide binding]; other site 283165000806 Transmembrane secretion effector; Region: MFS_3; pfam05977 283165000807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165000808 putative substrate translocation pore; other site 283165000809 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 283165000810 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 283165000811 RNA binding site [nucleotide binding]; other site 283165000812 active site 283165000813 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 283165000814 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 283165000815 translation initiation factor IF-2; Validated; Region: infB; PRK05306 283165000816 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 283165000817 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 283165000818 G1 box; other site 283165000819 putative GEF interaction site [polypeptide binding]; other site 283165000820 GTP/Mg2+ binding site [chemical binding]; other site 283165000821 Switch I region; other site 283165000822 G2 box; other site 283165000823 G3 box; other site 283165000824 Switch II region; other site 283165000825 G4 box; other site 283165000826 G5 box; other site 283165000827 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 283165000828 Translation-initiation factor 2; Region: IF-2; pfam11987 283165000829 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 283165000830 hypothetical protein; Provisional; Region: PRK09190 283165000831 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 283165000832 putative RNA binding cleft [nucleotide binding]; other site 283165000833 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 283165000834 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 283165000835 NusA N-terminal domain; Region: NusA_N; pfam08529 283165000836 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 283165000837 RNA binding site [nucleotide binding]; other site 283165000838 homodimer interface [polypeptide binding]; other site 283165000839 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 283165000840 G-X-X-G motif; other site 283165000841 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 283165000842 G-X-X-G motif; other site 283165000843 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 283165000844 ribosome maturation protein RimP; Reviewed; Region: PRK00092 283165000845 Sm and related proteins; Region: Sm_like; cl00259 283165000846 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 283165000847 putative oligomer interface [polypeptide binding]; other site 283165000848 putative RNA binding site [nucleotide binding]; other site 283165000849 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 283165000850 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 283165000851 S-adenosylmethionine synthetase; Validated; Region: PRK05250 283165000852 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 283165000853 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 283165000854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 283165000855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 283165000856 non-specific DNA binding site [nucleotide binding]; other site 283165000857 salt bridge; other site 283165000858 sequence-specific DNA binding site [nucleotide binding]; other site 283165000859 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 283165000860 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 283165000861 putative active site [active] 283165000862 catalytic triad [active] 283165000863 putative dimer interface [polypeptide binding]; other site 283165000864 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 283165000865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 283165000866 Transporter associated domain; Region: CorC_HlyC; smart01091 283165000867 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 283165000868 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 283165000869 PhoH-like protein; Region: PhoH; pfam02562 283165000870 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 283165000871 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 283165000872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 283165000873 FeS/SAM binding site; other site 283165000874 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 283165000875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 283165000876 Coenzyme A binding pocket [chemical binding]; other site 283165000877 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 283165000878 Glycoprotease family; Region: Peptidase_M22; pfam00814 283165000879 Identified by comparison to Bartonella henselae;hypothetical protein 283165000880 recombination protein RecR; Reviewed; Region: recR; PRK00076 283165000881 RecR protein; Region: RecR; pfam02132 283165000882 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 283165000883 putative active site [active] 283165000884 putative metal-binding site [ion binding]; other site 283165000885 tetramer interface [polypeptide binding]; other site 283165000886 hypothetical protein; Validated; Region: PRK00153 283165000887 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 283165000888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165000889 Walker A motif; other site 283165000890 ATP binding site [chemical binding]; other site 283165000891 Walker B motif; other site 283165000892 arginine finger; other site 283165000893 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 283165000894 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 283165000895 Identified by comparison to Bartonella henselae;chorismate mutase/prephenate dehydratase 283165000896 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 283165000897 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 283165000898 Ligand binding site; other site 283165000899 oligomer interface; other site 283165000900 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 283165000901 Cytochrome c2 [Energy production and conversion]; Region: COG3474 283165000902 Identified by comparison to Bartonella henselae;peptide abc transporter permease 283165000903 Identified by comparison to Bartonella henselae;peptide abc transporter permease 283165000904 Identified by comparison to Bartonella henselae;peptide abc transporter permease 283165000905 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 283165000906 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 283165000907 ATP binding site [chemical binding]; other site 283165000908 substrate interface [chemical binding]; other site 283165000909 glutathione synthetase; Provisional; Region: PRK05246 283165000910 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 283165000911 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 283165000912 PBP superfamily domain; Region: PBP_like_2; pfam12849 283165000913 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 283165000914 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 283165000915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165000916 dimer interface [polypeptide binding]; other site 283165000917 conserved gate region; other site 283165000918 putative PBP binding loops; other site 283165000919 ABC-ATPase subunit interface; other site 283165000920 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 283165000921 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 283165000922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165000923 dimer interface [polypeptide binding]; other site 283165000924 conserved gate region; other site 283165000925 putative PBP binding loops; other site 283165000926 ABC-ATPase subunit interface; other site 283165000927 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 283165000928 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 283165000929 Walker A/P-loop; other site 283165000930 ATP binding site [chemical binding]; other site 283165000931 Q-loop/lid; other site 283165000932 ABC transporter signature motif; other site 283165000933 Walker B; other site 283165000934 D-loop; other site 283165000935 H-loop/switch region; other site 283165000936 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 283165000937 PhoU domain; Region: PhoU; pfam01895 283165000938 PhoU domain; Region: PhoU; pfam01895 283165000939 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 283165000940 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 283165000941 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 283165000942 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 283165000943 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 283165000944 DNA binding site [nucleotide binding] 283165000945 catalytic residue [active] 283165000946 H2TH interface [polypeptide binding]; other site 283165000947 putative catalytic residues [active] 283165000948 turnover-facilitating residue; other site 283165000949 intercalation triad [nucleotide binding]; other site 283165000950 8OG recognition residue [nucleotide binding]; other site 283165000951 putative reading head residues; other site 283165000952 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 283165000953 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 283165000954 hypothetical protein; Validated; Region: PRK09104 283165000955 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 283165000956 metal binding site [ion binding]; metal-binding site 283165000957 putative dimer interface [polypeptide binding]; other site 283165000958 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 283165000959 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 283165000960 catalytic site [active] 283165000961 putative active site [active] 283165000962 putative substrate binding site [chemical binding]; other site 283165000963 Porin subfamily; Region: Porin_2; pfam02530 283165000964 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 283165000965 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 283165000966 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 283165000967 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 283165000968 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 283165000969 active site 283165000970 HIGH motif; other site 283165000971 nucleotide binding site [chemical binding]; other site 283165000972 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 283165000973 active site 283165000974 KMSKS motif; other site 283165000975 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 283165000976 tRNA binding surface [nucleotide binding]; other site 283165000977 anticodon binding site; other site 283165000978 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 283165000979 nucleoside/Zn binding site; other site 283165000980 dimer interface [polypeptide binding]; other site 283165000981 catalytic motif [active] 283165000982 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 283165000983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 283165000984 RNA binding surface [nucleotide binding]; other site 283165000985 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 283165000986 active site 283165000987 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 283165000988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165000989 S-adenosylmethionine binding site [chemical binding]; other site 283165000990 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 283165000991 Identified by comparison to Bartonella quintana;pmbA protein, maturation of antibiotic mccb17 283165000992 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 283165000993 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 283165000994 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 283165000995 active site 283165000996 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 283165000997 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 283165000998 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 283165000999 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 283165001000 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 283165001001 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 283165001002 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 283165001003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001004 ATP binding site [chemical binding]; other site 283165001005 Mg2+ binding site [ion binding]; other site 283165001006 G-X-G motif; other site 283165001007 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 283165001008 ATP binding site [chemical binding]; other site 283165001009 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 283165001010 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 283165001011 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 283165001012 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 283165001013 trimer interface [polypeptide binding]; other site 283165001014 active site 283165001015 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 283165001016 trimer interface [polypeptide binding]; other site 283165001017 active site 283165001018 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 283165001019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 283165001020 phosphate binding site [ion binding]; other site 283165001021 Identified by comparison to Bartonella henselae;hypothetical protein 283165001022 Identified by comparison to Bartonella henselae;hypothetical protein 283165001023 Identified by comparison to Bartonella henselae;hypothetical genomic island protein 283165001024 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 283165001025 catalytic residues [active] 283165001026 Identified by comparison to Bartonella henselae;hbp 283165001027 Identified by comparison to Bartonella henselae;gp24 phage-related baseplate assembly protein 283165001028 Identified by comparison to Bartonella henselae;vpd late control gene D protein 283165001029 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 283165001030 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 283165001031 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 283165001032 Walker A/P-loop; other site 283165001033 ATP binding site [chemical binding]; other site 283165001034 Q-loop/lid; other site 283165001035 ABC transporter signature motif; other site 283165001036 Walker B; other site 283165001037 D-loop; other site 283165001038 H-loop/switch region; other site 283165001039 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 283165001040 BioY family; Region: BioY; pfam02632 283165001041 Identified by comparison to Brucella melitensis;hypothetical membrane spanning 283165001042 Identified by comparison to Bartonella henselae;hypothetical protein 283165001043 Identified by comparison to Bartonella henselae;phage related protein 283165001044 Identified by comparison to Bartonella henselae;hypothetical genomic island protein 283165001045 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 283165001046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 283165001047 catalytic residue [active] 283165001048 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 283165001049 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 283165001050 GDP-binding site [chemical binding]; other site 283165001051 ACT binding site; other site 283165001052 IMP binding site; other site 283165001053 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 283165001054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 283165001055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 283165001056 DNA binding residues [nucleotide binding] 283165001057 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 283165001058 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 283165001059 RNA binding surface [nucleotide binding]; other site 283165001060 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 283165001061 active site 283165001062 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 283165001063 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 283165001064 NAD binding site [chemical binding]; other site 283165001065 catalytic residues [active] 283165001066 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 283165001067 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 283165001068 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 283165001069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165001070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165001071 dimer interface [polypeptide binding]; other site 283165001072 phosphorylation site [posttranslational modification] 283165001073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001074 ATP binding site [chemical binding]; other site 283165001075 Mg2+ binding site [ion binding]; other site 283165001076 G-X-G motif; other site 283165001077 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 283165001078 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 283165001079 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 283165001080 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 283165001081 quinone interaction residues [chemical binding]; other site 283165001082 active site 283165001083 catalytic residues [active] 283165001084 FMN binding site [chemical binding]; other site 283165001085 substrate binding site [chemical binding]; other site 283165001086 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 283165001087 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 283165001088 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 283165001089 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 283165001090 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 283165001091 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 283165001092 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 283165001093 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 283165001094 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 283165001095 putative active site [active] 283165001096 Identified by comparison to Bartonella henselae;phosphogluconate dehydratase 283165001097 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 283165001098 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 283165001099 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 283165001100 homodimer interface [polypeptide binding]; other site 283165001101 NADP binding site [chemical binding]; other site 283165001102 substrate binding site [chemical binding]; other site 283165001103 AsmA family; Region: AsmA; pfam05170 283165001104 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 283165001105 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 283165001106 RNA methyltransferase, RsmE family; Region: TIGR00046 283165001107 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 283165001108 Identified by comparison to Bartonella henselae;prophage integrase 283165001109 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 283165001110 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 283165001111 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 283165001112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 283165001113 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 283165001114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 283165001115 active site 283165001116 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 283165001117 GSH binding site [chemical binding]; other site 283165001118 catalytic residues [active] 283165001119 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 283165001120 Methyltransferase domain; Region: Methyltransf_11; pfam08241 283165001121 aspartate kinase; Reviewed; Region: PRK06635 283165001122 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 283165001123 putative nucleotide binding site [chemical binding]; other site 283165001124 putative catalytic residues [active] 283165001125 putative Mg ion binding site [ion binding]; other site 283165001126 putative aspartate binding site [chemical binding]; other site 283165001127 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 283165001128 putative allosteric regulatory site; other site 283165001129 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 283165001130 putative allosteric regulatory residue; other site 283165001131 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 283165001132 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 283165001133 transmembrane helices; other site 283165001134 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 283165001135 TrkA-C domain; Region: TrkA_C; pfam02080 283165001136 TrkA-C domain; Region: TrkA_C; pfam02080 283165001137 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 283165001138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 283165001139 GTP-binding protein Der; Reviewed; Region: PRK00093 283165001140 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 283165001141 G1 box; other site 283165001142 GTP/Mg2+ binding site [chemical binding]; other site 283165001143 Switch I region; other site 283165001144 G2 box; other site 283165001145 Switch II region; other site 283165001146 G3 box; other site 283165001147 G4 box; other site 283165001148 G5 box; other site 283165001149 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 283165001150 G1 box; other site 283165001151 GTP/Mg2+ binding site [chemical binding]; other site 283165001152 Switch I region; other site 283165001153 G2 box; other site 283165001154 G3 box; other site 283165001155 Switch II region; other site 283165001156 G4 box; other site 283165001157 G5 box; other site 283165001158 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 283165001159 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 283165001160 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 283165001161 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 283165001162 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 283165001163 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 283165001164 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 283165001165 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 283165001166 DALR anticodon binding domain; Region: DALR_1; pfam05746 283165001167 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 283165001168 dimer interface [polypeptide binding]; other site 283165001169 motif 1; other site 283165001170 active site 283165001171 motif 2; other site 283165001172 motif 3; other site 283165001173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 283165001174 binding surface 283165001175 Tetratricopeptide repeat; Region: TPR_16; pfam13432 283165001176 TPR motif; other site 283165001177 TPR repeat; Region: TPR_11; pfam13414 283165001178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 283165001179 binding surface 283165001180 TPR motif; other site 283165001181 TPR repeat; Region: TPR_11; pfam13414 283165001182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 283165001183 binding surface 283165001184 TPR motif; other site 283165001185 TPR repeat; Region: TPR_11; pfam13414 283165001186 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 283165001187 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 283165001188 substrate binding pocket [chemical binding]; other site 283165001189 chain length determination region; other site 283165001190 substrate-Mg2+ binding site; other site 283165001191 catalytic residues [active] 283165001192 aspartate-rich region 1; other site 283165001193 active site lid residues [active] 283165001194 aspartate-rich region 2; other site 283165001195 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 283165001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165001197 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 283165001198 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 283165001199 tandem repeat interface [polypeptide binding]; other site 283165001200 oligomer interface [polypeptide binding]; other site 283165001201 active site residues [active] 283165001202 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 283165001203 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 283165001204 Identified by comparison to Brucella melitensis;cytochrome c1 283165001205 PRC-barrel domain; Region: PRC; pfam05239 283165001206 GTP-binding protein YchF; Reviewed; Region: PRK09601 283165001207 YchF GTPase; Region: YchF; cd01900 283165001208 G1 box; other site 283165001209 GTP/Mg2+ binding site [chemical binding]; other site 283165001210 Switch I region; other site 283165001211 G2 box; other site 283165001212 Switch II region; other site 283165001213 G3 box; other site 283165001214 G4 box; other site 283165001215 G5 box; other site 283165001216 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 283165001217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 283165001218 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 283165001219 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 283165001220 putative active site [active] 283165001221 catalytic residue [active] 283165001222 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 283165001223 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 283165001224 5S rRNA interface [nucleotide binding]; other site 283165001225 CTC domain interface [polypeptide binding]; other site 283165001226 L16 interface [polypeptide binding]; other site 283165001227 Identified by comparison to Bartonella henselae;hypothetical protein 283165001228 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 283165001229 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 283165001230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 283165001231 active site 283165001232 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 283165001233 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 283165001234 Uncharacterized conserved protein [Function unknown]; Region: COG1565 283165001235 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 283165001236 Membrane fusogenic activity; Region: BMFP; pfam04380 283165001237 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 283165001238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165001239 HAMP domain; Region: HAMP; pfam00672 283165001240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 283165001241 dimer interface [polypeptide binding]; other site 283165001242 phosphorylation site [posttranslational modification] 283165001243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001244 ATP binding site [chemical binding]; other site 283165001245 Mg2+ binding site [ion binding]; other site 283165001246 G-X-G motif; other site 283165001247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 283165001248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165001249 active site 283165001250 phosphorylation site [posttranslational modification] 283165001251 intermolecular recognition site; other site 283165001252 dimerization interface [polypeptide binding]; other site 283165001253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 283165001254 DNA binding site [nucleotide binding] 283165001255 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 283165001256 BA14K-like protein; Region: BA14K; pfam07886 283165001257 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 283165001258 RNA/DNA hybrid binding site [nucleotide binding]; other site 283165001259 active site 283165001260 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 283165001261 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 283165001262 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 283165001263 FAD binding domain; Region: FAD_binding_4; pfam01565 283165001264 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 283165001265 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 283165001266 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 283165001267 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 283165001268 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 283165001269 UbiA prenyltransferase family; Region: UbiA; pfam01040 283165001270 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 283165001271 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 283165001272 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 283165001273 chaperone protein DnaJ; Provisional; Region: PRK14299 283165001274 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 283165001275 HSP70 interaction site [polypeptide binding]; other site 283165001276 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 283165001277 dimer interface [polypeptide binding]; other site 283165001278 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 283165001279 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 283165001280 NAD binding site [chemical binding]; other site 283165001281 homotetramer interface [polypeptide binding]; other site 283165001282 homodimer interface [polypeptide binding]; other site 283165001283 substrate binding site [chemical binding]; other site 283165001284 active site 283165001285 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 283165001286 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 283165001287 Tetramer interface [polypeptide binding]; other site 283165001288 active site 283165001289 FMN-binding site [chemical binding]; other site 283165001290 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 283165001291 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 283165001292 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 283165001293 dimerization interface [polypeptide binding]; other site 283165001294 active site 283165001295 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 283165001296 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 283165001297 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 283165001298 TPP-binding site; other site 283165001299 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 283165001300 PYR/PP interface [polypeptide binding]; other site 283165001301 dimer interface [polypeptide binding]; other site 283165001302 TPP binding site [chemical binding]; other site 283165001303 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 283165001304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165001305 S-adenosylmethionine binding site [chemical binding]; other site 283165001306 Identified by comparison to Bartonella henselae;rna methyltransferase 283165001307 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 283165001308 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 283165001309 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 283165001310 UbiA prenyltransferase family; Region: UbiA; pfam01040 283165001311 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 283165001312 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 283165001313 Identified by comparison to Bartonella henselae;thrB 283165001314 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 283165001315 RNA/DNA hybrid binding site [nucleotide binding]; other site 283165001316 active site 283165001317 Identified by comparison to Bartonella henselae;hypothetical protein 283165001318 hypothetical protein; Validated; Region: PRK00228 283165001319 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 283165001320 PAS fold; Region: PAS_3; pfam08447 283165001321 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 283165001322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 283165001323 metal binding site [ion binding]; metal-binding site 283165001324 active site 283165001325 I-site; other site 283165001326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 283165001327 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 283165001328 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 283165001329 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 283165001330 Identified by comparison to Bartonella henselae;thrC 283165001331 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 283165001332 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 283165001333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 283165001334 motif II; other site 283165001335 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 283165001336 DNA methylase; Region: N6_N4_Mtase; pfam01555 283165001337 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 283165001338 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 283165001339 minor groove reading motif; other site 283165001340 helix-hairpin-helix signature motif; other site 283165001341 substrate binding pocket [chemical binding]; other site 283165001342 active site 283165001343 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 283165001344 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 283165001345 DNA binding and oxoG recognition site [nucleotide binding] 283165001346 Protein of unknown function (DUF721); Region: DUF721; cl02324 283165001347 Thioredoxin; Region: Thioredoxin_4; pfam13462 283165001348 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 283165001349 pyruvate phosphate dikinase; Provisional; Region: PRK09279 283165001350 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 283165001351 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 283165001352 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 283165001353 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 283165001354 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 283165001355 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 283165001356 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 283165001357 Predicted transcriptional regulator [Transcription]; Region: COG4957 283165001358 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 283165001359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 283165001360 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 283165001361 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 283165001362 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 283165001363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 283165001364 Walker A/P-loop; other site 283165001365 ATP binding site [chemical binding]; other site 283165001366 Q-loop/lid; other site 283165001367 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 283165001368 Predicted integral membrane protein [Function unknown]; Region: COG5436 283165001369 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 283165001370 Transglycosylase; Region: Transgly; pfam00912 283165001371 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 283165001372 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 283165001373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 283165001374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165001375 active site 283165001376 phosphorylation site [posttranslational modification] 283165001377 intermolecular recognition site; other site 283165001378 dimerization interface [polypeptide binding]; other site 283165001379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 283165001380 DNA binding site [nucleotide binding] 283165001381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165001382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001383 ATP binding site [chemical binding]; other site 283165001384 Mg2+ binding site [ion binding]; other site 283165001385 G-X-G motif; other site 283165001386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 283165001387 TPR motif; other site 283165001388 binding surface 283165001389 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 283165001390 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 283165001391 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 283165001392 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 283165001393 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 283165001394 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 283165001395 protein binding site [polypeptide binding]; other site 283165001396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 283165001397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165001398 active site 283165001399 phosphorylation site [posttranslational modification] 283165001400 intermolecular recognition site; other site 283165001401 dimerization interface [polypeptide binding]; other site 283165001402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 283165001403 DNA binding site [nucleotide binding] 283165001404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165001405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 283165001406 dimerization interface [polypeptide binding]; other site 283165001407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165001408 dimer interface [polypeptide binding]; other site 283165001409 phosphorylation site [posttranslational modification] 283165001410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001411 ATP binding site [chemical binding]; other site 283165001412 Mg2+ binding site [ion binding]; other site 283165001413 G-X-G motif; other site 283165001414 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 283165001415 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 283165001416 metal binding triad; other site 283165001417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 283165001418 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 283165001419 metal binding triad; other site 283165001420 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 283165001421 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 283165001422 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 283165001423 DNA binding site [nucleotide binding] 283165001424 active site 283165001425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 283165001426 PAS fold; Region: PAS_3; pfam08447 283165001427 putative active site [active] 283165001428 heme pocket [chemical binding]; other site 283165001429 PAS fold; Region: PAS_7; pfam12860 283165001430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165001431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165001432 dimer interface [polypeptide binding]; other site 283165001433 phosphorylation site [posttranslational modification] 283165001434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001435 ATP binding site [chemical binding]; other site 283165001436 Mg2+ binding site [ion binding]; other site 283165001437 G-X-G motif; other site 283165001438 aminopeptidase N; Provisional; Region: pepN; PRK14015 283165001439 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 283165001440 active site 283165001441 Zn binding site [ion binding]; other site 283165001442 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 283165001443 Fe-S cluster binding site [ion binding]; other site 283165001444 active site 283165001445 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 283165001446 substrate binding site [chemical binding]; other site 283165001447 dimer interface [polypeptide binding]; other site 283165001448 ATP binding site [chemical binding]; other site 283165001449 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 283165001450 thiamine phosphate binding site [chemical binding]; other site 283165001451 active site 283165001452 pyrophosphate binding site [ion binding]; other site 283165001453 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 283165001454 ThiS interaction site; other site 283165001455 putative active site [active] 283165001456 tetramer interface [polypeptide binding]; other site 283165001457 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 283165001458 thiS-thiF/thiG interaction site; other site 283165001459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 283165001460 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 283165001461 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 283165001462 ThiC-associated domain; Region: ThiC-associated; pfam13667 283165001463 ThiC family; Region: ThiC; pfam01964 283165001464 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 283165001465 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 283165001466 Walker A/P-loop; other site 283165001467 ATP binding site [chemical binding]; other site 283165001468 Q-loop/lid; other site 283165001469 ABC transporter signature motif; other site 283165001470 Walker B; other site 283165001471 D-loop; other site 283165001472 H-loop/switch region; other site 283165001473 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 283165001474 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 283165001475 ABC-ATPase subunit interface; other site 283165001476 dimer interface [polypeptide binding]; other site 283165001477 putative PBP binding regions; other site 283165001478 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 283165001479 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 283165001480 putative hemin binding site; other site 283165001481 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 283165001482 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 283165001483 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 283165001484 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 283165001485 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 283165001486 N-terminal plug; other site 283165001487 ligand-binding site [chemical binding]; other site 283165001488 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 283165001489 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 283165001490 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 283165001491 N-acetyl-D-glucosamine binding site [chemical binding]; other site 283165001492 catalytic residue [active] 283165001493 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 283165001494 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 283165001495 dimer interface [polypeptide binding]; other site 283165001496 active site 283165001497 catalytic residue [active] 283165001498 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 283165001499 SmpB-tmRNA interface; other site 283165001500 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 283165001501 Fe-S cluster binding site [ion binding]; other site 283165001502 DNA binding site [nucleotide binding] 283165001503 active site 283165001504 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 283165001505 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 283165001506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 283165001507 Zn2+ binding site [ion binding]; other site 283165001508 Mg2+ binding site [ion binding]; other site 283165001509 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 283165001510 synthetase active site [active] 283165001511 NTP binding site [chemical binding]; other site 283165001512 metal binding site [ion binding]; metal-binding site 283165001513 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 283165001514 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 283165001515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 283165001516 active site 283165001517 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 283165001518 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 283165001519 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 283165001520 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 283165001521 Catalytic site [active] 283165001522 ribonuclease III; Reviewed; Region: PRK12371 283165001523 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 283165001524 dimerization interface [polypeptide binding]; other site 283165001525 active site 283165001526 metal binding site [ion binding]; metal-binding site 283165001527 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 283165001528 dsRNA binding site [nucleotide binding]; other site 283165001529 GTPase Era; Reviewed; Region: era; PRK00089 283165001530 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 283165001531 G1 box; other site 283165001532 GTP/Mg2+ binding site [chemical binding]; other site 283165001533 Switch I region; other site 283165001534 G2 box; other site 283165001535 Switch II region; other site 283165001536 G3 box; other site 283165001537 G4 box; other site 283165001538 G5 box; other site 283165001539 KH domain; Region: KH_2; pfam07650 283165001540 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 283165001541 Recombination protein O N terminal; Region: RecO_N; pfam11967 283165001542 Recombination protein O C terminal; Region: RecO_C; pfam02565 283165001543 pantoate--beta-alanine ligase; Region: panC; TIGR00018 283165001544 Pantoate-beta-alanine ligase; Region: PanC; cd00560 283165001545 active site 283165001546 ATP-binding site [chemical binding]; other site 283165001547 pantoate-binding site; other site 283165001548 HXXH motif; other site 283165001549 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 283165001550 active site 283165001551 oligomerization interface [polypeptide binding]; other site 283165001552 metal binding site [ion binding]; metal-binding site 283165001553 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 283165001554 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 283165001555 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 283165001556 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 283165001557 dihydroorotase; Validated; Region: PRK09060 283165001558 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 283165001559 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 283165001560 active site 283165001561 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 283165001562 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 283165001563 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 283165001564 active site 283165001565 HIGH motif; other site 283165001566 nucleotide binding site [chemical binding]; other site 283165001567 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 283165001568 KMSKS motif; other site 283165001569 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 283165001570 tRNA binding surface [nucleotide binding]; other site 283165001571 anticodon binding site; other site 283165001572 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 283165001573 Predicted membrane protein [Function unknown]; Region: COG2323 283165001574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 283165001575 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 283165001576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 283165001577 Walker A/P-loop; other site 283165001578 ATP binding site [chemical binding]; other site 283165001579 Q-loop/lid; other site 283165001580 ABC transporter signature motif; other site 283165001581 Walker B; other site 283165001582 D-loop; other site 283165001583 H-loop/switch region; other site 283165001584 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 283165001585 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 283165001586 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 283165001587 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 283165001588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 283165001589 NAD(P) binding site [chemical binding]; other site 283165001590 active site 283165001591 amidophosphoribosyltransferase; Provisional; Region: PRK09123 283165001592 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 283165001593 active site 283165001594 tetramer interface [polypeptide binding]; other site 283165001595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 283165001596 active site 283165001597 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 283165001598 Colicin V production protein; Region: Colicin_V; pfam02674 283165001599 DNA repair protein RadA; Provisional; Region: PRK11823 283165001600 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 283165001601 Walker A motif/ATP binding site; other site 283165001602 ATP binding site [chemical binding]; other site 283165001603 Walker B motif; other site 283165001604 replicative DNA helicase; Provisional; Region: PRK09165 283165001605 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 283165001606 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 283165001607 Walker A motif; other site 283165001608 ATP binding site [chemical binding]; other site 283165001609 Walker B motif; other site 283165001610 DNA binding loops [nucleotide binding] 283165001611 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 283165001612 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 283165001613 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 283165001614 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 283165001615 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 283165001616 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 283165001617 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 283165001618 active site 283165001619 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 283165001620 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 283165001621 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 283165001622 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 283165001623 NAD(P) binding site [chemical binding]; other site 283165001624 homotetramer interface [polypeptide binding]; other site 283165001625 homodimer interface [polypeptide binding]; other site 283165001626 active site 283165001627 acyl carrier protein; Provisional; Region: acpP; PRK00982 283165001628 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 283165001629 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 283165001630 dimer interface [polypeptide binding]; other site 283165001631 active site 283165001632 YceG-like family; Region: YceG; pfam02618 283165001633 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 283165001634 dimerization interface [polypeptide binding]; other site 283165001635 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 283165001636 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 283165001637 catalytic site [active] 283165001638 G-X2-G-X-G-K; other site 283165001639 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 283165001640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165001641 S-adenosylmethionine binding site [chemical binding]; other site 283165001642 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 283165001643 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 283165001644 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 283165001645 SurA N-terminal domain; Region: SurA_N; pfam09312 283165001646 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 283165001647 OstA-like protein; Region: OstA; cl00844 283165001648 Organic solvent tolerance protein; Region: OstA_C; pfam04453 283165001649 Predicted permeases [General function prediction only]; Region: COG0795 283165001650 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 283165001651 Predicted permeases [General function prediction only]; Region: COG0795 283165001652 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 283165001653 DNA polymerase III subunit chi; Validated; Region: PRK05728 283165001654 metabolite-proton symporter; Region: 2A0106; TIGR00883 283165001655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165001656 putative substrate translocation pore; other site 283165001657 Identified by comparison to Bartonella henselae;hypothetical protein 283165001658 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 283165001659 Autotransporter beta-domain; Region: Autotransporter; smart00869 283165001660 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 283165001661 active site 283165001662 multimer interface [polypeptide binding]; other site 283165001663 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 283165001664 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 283165001665 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 283165001666 GIY-YIG motif/motif A; other site 283165001667 active site 283165001668 catalytic site [active] 283165001669 putative DNA binding site [nucleotide binding]; other site 283165001670 metal binding site [ion binding]; metal-binding site 283165001671 UvrB/uvrC motif; Region: UVR; pfam02151 283165001672 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 283165001673 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 283165001674 Identified by comparison to Mesorhizobium loti;probable sugar hydrolase 283165001675 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 283165001676 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 283165001677 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 283165001678 seryl-tRNA synthetase; Provisional; Region: PRK05431 283165001679 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 283165001680 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 283165001681 dimer interface [polypeptide binding]; other site 283165001682 active site 283165001683 motif 1; other site 283165001684 motif 2; other site 283165001685 motif 3; other site 283165001686 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 283165001687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165001688 S-adenosylmethionine binding site [chemical binding]; other site 283165001689 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 283165001690 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 283165001691 Peptidase family M23; Region: Peptidase_M23; pfam01551 283165001692 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 283165001693 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 283165001694 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 283165001695 substrate binding pocket [chemical binding]; other site 283165001696 substrate-Mg2+ binding site; other site 283165001697 aspartate-rich region 2; other site 283165001698 SurA N-terminal domain; Region: SurA_N_3; cl07813 283165001699 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 283165001700 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 283165001701 triosephosphate isomerase; Provisional; Region: PRK14565 283165001702 substrate binding site [chemical binding]; other site 283165001703 dimer interface [polypeptide binding]; other site 283165001704 catalytic triad [active] 283165001705 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 283165001706 CTP synthetase; Validated; Region: pyrG; PRK05380 283165001707 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 283165001708 Catalytic site [active] 283165001709 active site 283165001710 UTP binding site [chemical binding]; other site 283165001711 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 283165001712 active site 283165001713 putative oxyanion hole; other site 283165001714 catalytic triad [active] 283165001715 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 283165001716 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 283165001717 enolase; Provisional; Region: eno; PRK00077 283165001718 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 283165001719 dimer interface [polypeptide binding]; other site 283165001720 metal binding site [ion binding]; metal-binding site 283165001721 substrate binding pocket [chemical binding]; other site 283165001722 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 283165001723 RNA binding site [nucleotide binding]; other site 283165001724 TM2 domain; Region: TM2; pfam05154 283165001725 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 283165001726 Septum formation initiator; Region: DivIC; pfam04977 283165001727 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 283165001728 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 283165001729 tetramer interface [polypeptide binding]; other site 283165001730 TPP-binding site [chemical binding]; other site 283165001731 heterodimer interface [polypeptide binding]; other site 283165001732 phosphorylation loop region [posttranslational modification] 283165001733 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 283165001734 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 283165001735 E3 interaction surface; other site 283165001736 lipoyl attachment site [posttranslational modification]; other site 283165001737 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 283165001738 alpha subunit interface [polypeptide binding]; other site 283165001739 TPP binding site [chemical binding]; other site 283165001740 heterodimer interface [polypeptide binding]; other site 283165001741 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 283165001742 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 283165001743 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 283165001744 E3 interaction surface; other site 283165001745 lipoyl attachment site [posttranslational modification]; other site 283165001746 e3 binding domain; Region: E3_binding; pfam02817 283165001747 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 283165001748 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 283165001749 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 283165001750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 283165001751 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 283165001752 lipoyl synthase; Provisional; Region: PRK05481 283165001753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 283165001754 FeS/SAM binding site; other site 283165001755 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 283165001756 putative coenzyme Q binding site [chemical binding]; other site 283165001757 Competence-damaged protein; Region: CinA; pfam02464 283165001758 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 283165001759 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 283165001760 substrate binding site; other site 283165001761 dimer interface; other site 283165001762 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 283165001763 homotrimer interaction site [polypeptide binding]; other site 283165001764 zinc binding site [ion binding]; other site 283165001765 CDP-binding sites; other site 283165001766 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 283165001767 Predicted transcriptional regulator [Transcription]; Region: COG1959 283165001768 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 283165001769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 283165001770 dimerization interface [polypeptide binding]; other site 283165001771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165001772 dimer interface [polypeptide binding]; other site 283165001773 phosphorylation site [posttranslational modification] 283165001774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165001775 ATP binding site [chemical binding]; other site 283165001776 Mg2+ binding site [ion binding]; other site 283165001777 G-X-G motif; other site 283165001778 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 283165001779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165001780 active site 283165001781 phosphorylation site [posttranslational modification] 283165001782 intermolecular recognition site; other site 283165001783 dimerization interface [polypeptide binding]; other site 283165001784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165001785 Walker A motif; other site 283165001786 ATP binding site [chemical binding]; other site 283165001787 Walker B motif; other site 283165001788 arginine finger; other site 283165001789 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 283165001790 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 283165001791 TrkA-N domain; Region: TrkA_N; pfam02254 283165001792 TrkA-C domain; Region: TrkA_C; pfam02080 283165001793 TrkA-N domain; Region: TrkA_N; pfam02254 283165001794 TrkA-C domain; Region: TrkA_C; pfam02080 283165001795 Identified by comparison to Brucella melitensis;hypothetical protein 283165001796 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 283165001797 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 283165001798 oligomer interface [polypeptide binding]; other site 283165001799 active site residues [active] 283165001800 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 283165001801 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 283165001802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165001803 Walker A motif; other site 283165001804 ATP binding site [chemical binding]; other site 283165001805 Walker B motif; other site 283165001806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 283165001807 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 283165001808 Found in ATP-dependent protease La (LON); Region: LON; smart00464 283165001809 Found in ATP-dependent protease La (LON); Region: LON; smart00464 283165001810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165001811 Walker A motif; other site 283165001812 ATP binding site [chemical binding]; other site 283165001813 Walker B motif; other site 283165001814 arginine finger; other site 283165001815 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 283165001816 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 283165001817 IHF dimer interface [polypeptide binding]; other site 283165001818 IHF - DNA interface [nucleotide binding]; other site 283165001819 Identified by comparison to Bartonella henselae;gidA 283165001820 Identified by comparison to Bartonella henselae;hypothetical protein 283165001821 Identified by comparison to Bartonella henselae;hypothetical protein 283165001822 Identified by comparison to Bartonella henselae;hypothetical protein 283165001823 Identified by comparison to Bartonella henselae;hypothetical protein 283165001824 Identified by comparison to Bartonella henselae;hypothetical protein 283165001825 Identified by comparison to Bartonella henselae;virulence-associated protein 283165001826 Identified by comparison to Bartonella henselae;vapA hypothetical protein 283165001827 Identified by comparison to Bartonella henselae;hypothetical protein 283165001828 Identified by comparison to Bartonella henselae;hypothetical protein 283165001829 Response regulator receiver domain; Region: Response_reg; pfam00072 283165001830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165001831 active site 283165001832 phosphorylation site [posttranslational modification] 283165001833 intermolecular recognition site; other site 283165001834 dimerization interface [polypeptide binding]; other site 283165001835 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 283165001836 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 283165001837 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 283165001838 putative dimer interface [polypeptide binding]; other site 283165001839 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 283165001840 Identified by comparison to Bartonella henselae;mazG 283165001841 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 283165001842 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 283165001843 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 283165001844 putative acyl-acceptor binding pocket; other site 283165001845 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 283165001846 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 283165001847 NAD(P) binding site [chemical binding]; other site 283165001848 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 283165001849 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 283165001850 dimer interface [polypeptide binding]; other site 283165001851 active site 283165001852 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 283165001853 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 283165001854 active site 283165001855 acyl carrier protein; Provisional; Region: PRK06508 283165001856 malic enzyme; Reviewed; Region: PRK12862 283165001857 Malic enzyme, N-terminal domain; Region: malic; pfam00390 283165001858 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 283165001859 putative NAD(P) binding site [chemical binding]; other site 283165001860 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 283165001861 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 283165001862 Predicted membrane protein [Function unknown]; Region: COG1511 283165001863 bacterial Hfq-like; Region: Hfq; cd01716 283165001864 hexamer interface [polypeptide binding]; other site 283165001865 Sm1 motif; other site 283165001866 RNA binding site [nucleotide binding]; other site 283165001867 Sm2 motif; other site 283165001868 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 283165001869 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 283165001870 HflX GTPase family; Region: HflX; cd01878 283165001871 G1 box; other site 283165001872 GTP/Mg2+ binding site [chemical binding]; other site 283165001873 Switch I region; other site 283165001874 G2 box; other site 283165001875 G3 box; other site 283165001876 Switch II region; other site 283165001877 G4 box; other site 283165001878 G5 box; other site 283165001879 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 283165001880 AAA domain; Region: AAA_31; pfam13614 283165001881 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 283165001882 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 283165001883 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 283165001884 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 283165001885 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 283165001886 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 283165001887 dimer interface [polypeptide binding]; other site 283165001888 active site 283165001889 glycine-pyridoxal phosphate binding site [chemical binding]; other site 283165001890 folate binding site [chemical binding]; other site 283165001891 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 283165001892 ATP cone domain; Region: ATP-cone; pfam03477 283165001893 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 283165001894 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 283165001895 catalytic motif [active] 283165001896 Zn binding site [ion binding]; other site 283165001897 RibD C-terminal domain; Region: RibD_C; cl17279 283165001898 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 283165001899 Lumazine binding domain; Region: Lum_binding; pfam00677 283165001900 Lumazine binding domain; Region: Lum_binding; pfam00677 283165001901 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 283165001902 homopentamer interface [polypeptide binding]; other site 283165001903 active site 283165001904 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 283165001905 putative RNA binding site [nucleotide binding]; other site 283165001906 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 283165001907 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 283165001908 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 283165001909 putative phosphate acyltransferase; Provisional; Region: PRK05331 283165001910 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 283165001911 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 283165001912 dimer interface [polypeptide binding]; other site 283165001913 active site 283165001914 CoA binding pocket [chemical binding]; other site 283165001915 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 283165001916 IHF dimer interface [polypeptide binding]; other site 283165001917 IHF - DNA interface [nucleotide binding]; other site 283165001918 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 283165001919 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 283165001920 DNA binding residues [nucleotide binding] 283165001921 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 283165001922 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 283165001923 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 283165001924 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 283165001925 active site 283165001926 dimer interface [polypeptide binding]; other site 283165001927 motif 1; other site 283165001928 motif 2; other site 283165001929 motif 3; other site 283165001930 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 283165001931 anticodon binding site; other site 283165001932 hypothetical protein; Validated; Region: PRK00041 283165001933 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 283165001934 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 283165001935 trimerization site [polypeptide binding]; other site 283165001936 active site 283165001937 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 283165001938 homodecamer interface [polypeptide binding]; other site 283165001939 GTP cyclohydrolase I; Provisional; Region: PLN03044 283165001940 active site 283165001941 putative catalytic site residues [active] 283165001942 zinc binding site [ion binding]; other site 283165001943 GTP-CH-I/GFRP interaction surface; other site 283165001944 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 283165001945 Identified by comparison to Sinorhizobium meliloti; integrase dna protein 283165001946 Identified by comparison to Bartonella henselae;hypothetical protein 283165001947 Identified by comparison to Bartonella quintana;hypothetical prophage protein 283165001948 Identified by comparison to Agrobacterium tumefaciens;hypothetical protein 283165001949 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 283165001950 NADH dehydrogenase subunit B; Validated; Region: PRK06411 283165001951 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 283165001952 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 283165001953 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 283165001954 NADH dehydrogenase subunit D; Validated; Region: PRK06075 283165001955 NADH dehydrogenase subunit E; Validated; Region: PRK07539 283165001956 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 283165001957 putative dimer interface [polypeptide binding]; other site 283165001958 [2Fe-2S] cluster binding site [ion binding]; other site 283165001959 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 283165001960 SLBB domain; Region: SLBB; pfam10531 283165001961 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 283165001962 NADH dehydrogenase subunit G; Validated; Region: PRK09130 283165001963 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 283165001964 catalytic loop [active] 283165001965 iron binding site [ion binding]; other site 283165001966 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 283165001967 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 283165001968 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 283165001969 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 283165001970 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 283165001971 4Fe-4S binding domain; Region: Fer4; pfam00037 283165001972 4Fe-4S binding domain; Region: Fer4; pfam00037 283165001973 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 283165001974 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 283165001975 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 283165001976 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 283165001977 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 283165001978 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 283165001979 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 283165001980 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 283165001981 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 283165001982 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 283165001983 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 283165001984 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 283165001985 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 283165001986 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 283165001987 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 283165001988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 283165001989 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 283165001990 prolyl-tRNA synthetase; Provisional; Region: PRK12325 283165001991 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 283165001992 dimer interface [polypeptide binding]; other site 283165001993 motif 1; other site 283165001994 active site 283165001995 motif 2; other site 283165001996 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 283165001997 active site 283165001998 motif 3; other site 283165001999 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 283165002000 anticodon binding site; other site 283165002001 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 283165002002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 283165002003 FtsX-like permease family; Region: FtsX; pfam02687 283165002004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 283165002005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 283165002006 Walker A/P-loop; other site 283165002007 ATP binding site [chemical binding]; other site 283165002008 Q-loop/lid; other site 283165002009 ABC transporter signature motif; other site 283165002010 Walker B; other site 283165002011 D-loop; other site 283165002012 H-loop/switch region; other site 283165002013 Uncharacterized conserved protein [Function unknown]; Region: COG2938 283165002014 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 283165002015 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 283165002016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 283165002017 ATP binding site [chemical binding]; other site 283165002018 putative Mg++ binding site [ion binding]; other site 283165002019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 283165002020 nucleotide binding region [chemical binding]; other site 283165002021 ATP-binding site [chemical binding]; other site 283165002022 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 283165002023 Identified by comparison to Bartonella henselae;transmembrane protein 283165002024 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 283165002025 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 283165002026 RNA binding site [nucleotide binding]; other site 283165002027 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 283165002028 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 283165002029 AMIN domain; Region: AMIN; pfam11741 283165002030 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 283165002031 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 283165002032 active site 283165002033 metal binding site [ion binding]; metal-binding site 283165002034 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 283165002035 Transglycosylase; Region: Transgly; pfam00912 283165002036 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 283165002037 peptide chain release factor 2; Provisional; Region: PRK07342 283165002038 This domain is found in peptide chain release factors; Region: PCRF; smart00937 283165002039 RF-1 domain; Region: RF-1; pfam00472 283165002040 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 283165002041 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 283165002042 catalytic triad [active] 283165002043 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 283165002044 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 283165002045 active site 283165002046 HIGH motif; other site 283165002047 dimer interface [polypeptide binding]; other site 283165002048 KMSKS motif; other site 283165002049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 283165002050 RNA binding surface [nucleotide binding]; other site 283165002051 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 283165002052 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 283165002053 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 283165002054 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 283165002055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 283165002056 catalytic residue [active] 283165002057 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 283165002058 putative ABC transporter; Region: ycf24; CHL00085 283165002059 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 283165002060 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 283165002061 Walker A/P-loop; other site 283165002062 ATP binding site [chemical binding]; other site 283165002063 Q-loop/lid; other site 283165002064 ABC transporter signature motif; other site 283165002065 Walker B; other site 283165002066 D-loop; other site 283165002067 H-loop/switch region; other site 283165002068 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 283165002069 FeS assembly protein SufD; Region: sufD; TIGR01981 283165002070 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 283165002071 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 283165002072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 283165002073 catalytic residue [active] 283165002074 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 283165002075 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 283165002076 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 283165002077 Identified by comparison to Sinorhizobium meliloti;hypothetical protein 283165002078 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 283165002079 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 283165002080 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 283165002081 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 283165002082 Identified by comparison to Bartonella henselae;3-hydroxyisobutyryl-coenzyme A hydrolase 283165002083 Identified by comparison to Bartonella henselae;hypothetical protein 283165002084 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 283165002085 putative hydrolase; Provisional; Region: PRK02113 283165002086 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 283165002087 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 283165002088 active site 283165002089 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 283165002090 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 283165002091 active site 283165002092 HIGH motif; other site 283165002093 KMSKS motif; other site 283165002094 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 283165002095 anticodon binding site; other site 283165002096 tRNA binding surface [nucleotide binding]; other site 283165002097 DNA polymerase III subunit delta'; Validated; Region: PRK09112 283165002098 DNA polymerase III subunit delta'; Validated; Region: PRK08485 283165002099 thymidylate kinase; Validated; Region: tmk; PRK00698 283165002100 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 283165002101 TMP-binding site; other site 283165002102 ATP-binding site [chemical binding]; other site 283165002103 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 283165002104 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 283165002105 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 283165002106 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 283165002107 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 283165002108 Identified by comparison to Bartonella henselae;integrase/recombinase 283165002109 LexA repressor; Validated; Region: PRK00215 283165002110 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 283165002111 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 283165002112 Catalytic site [active] 283165002113 Identified by comparison to Bartonella henselae;hypothetical protein 283165002114 Identified by comparison to Bartonella henselae;hypothetical protein 283165002115 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 283165002116 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 283165002117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 283165002118 RNA binding surface [nucleotide binding]; other site 283165002119 glutamate racemase; Provisional; Region: PRK00865 283165002120 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 283165002121 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 283165002122 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 283165002123 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 283165002124 active site 283165002125 hypothetical protein; Reviewed; Region: PRK00024 283165002126 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 283165002127 MPN+ (JAMM) motif; other site 283165002128 Zinc-binding site [ion binding]; other site 283165002129 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 283165002130 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 283165002131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 283165002132 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 283165002133 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 283165002134 DNA-binding site [nucleotide binding]; DNA binding site 283165002135 RNA-binding motif; other site 283165002136 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 283165002137 DNA-binding site [nucleotide binding]; DNA binding site 283165002138 RNA-binding motif; other site 283165002139 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 283165002140 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 283165002141 putative ligand binding site [chemical binding]; other site 283165002142 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 283165002143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 283165002144 TM-ABC transporter signature motif; other site 283165002145 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 283165002146 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 283165002147 TM-ABC transporter signature motif; other site 283165002148 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 283165002149 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 283165002150 Walker A/P-loop; other site 283165002151 ATP binding site [chemical binding]; other site 283165002152 Q-loop/lid; other site 283165002153 ABC transporter signature motif; other site 283165002154 Walker B; other site 283165002155 D-loop; other site 283165002156 H-loop/switch region; other site 283165002157 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 283165002158 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 283165002159 Walker A/P-loop; other site 283165002160 ATP binding site [chemical binding]; other site 283165002161 Q-loop/lid; other site 283165002162 ABC transporter signature motif; other site 283165002163 Walker B; other site 283165002164 D-loop; other site 283165002165 H-loop/switch region; other site 283165002166 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 283165002167 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 283165002168 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 283165002169 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 283165002170 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 283165002171 active site 283165002172 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 283165002173 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 283165002174 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 283165002175 dihydroorotase; Validated; Region: PRK09059 283165002176 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 283165002177 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 283165002178 active site 283165002179 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 283165002180 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 283165002181 DNA protecting protein DprA; Region: dprA; TIGR00732 283165002182 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 283165002183 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 283165002184 active site 283165002185 interdomain interaction site; other site 283165002186 putative metal-binding site [ion binding]; other site 283165002187 nucleotide binding site [chemical binding]; other site 283165002188 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 283165002189 domain I; other site 283165002190 DNA binding groove [nucleotide binding] 283165002191 phosphate binding site [ion binding]; other site 283165002192 domain II; other site 283165002193 domain III; other site 283165002194 nucleotide binding site [chemical binding]; other site 283165002195 catalytic site [active] 283165002196 domain IV; other site 283165002197 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 283165002198 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 283165002199 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 283165002200 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 283165002201 ribonuclease R; Region: RNase_R; TIGR02063 283165002202 RNB domain; Region: RNB; pfam00773 283165002203 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 283165002204 RNA binding site [nucleotide binding]; other site 283165002205 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 283165002206 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 283165002207 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 283165002208 Catalytic site; other site 283165002209 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 283165002210 putative uracil binding site [chemical binding]; other site 283165002211 putative active site [active] 283165002212 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 283165002213 AsnC family; Region: AsnC_trans_reg; pfam01037 283165002214 Identified by comparison to Bartonella henselae;cobT 283165002215 Identified by comparison to Bartonella henselae;transcriptional regulator 283165002216 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 283165002217 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 283165002218 FMN binding site [chemical binding]; other site 283165002219 active site 283165002220 catalytic residues [active] 283165002221 substrate binding site [chemical binding]; other site 283165002222 Identified by comparison to Bartonella henselae;outer membrane protein 283165002223 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 283165002224 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 283165002225 carboxyltransferase (CT) interaction site; other site 283165002226 biotinylation site [posttranslational modification]; other site 283165002227 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 283165002228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 283165002229 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 283165002230 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 283165002231 Identified by comparison to Bartonella henselae;hypothetical protein 283165002232 Identified by comparison to Bartonella henselae;phage related lysozyme 283165002233 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 283165002234 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 283165002235 Repair protein; Region: Repair_PSII; pfam04536 283165002236 lipoate-protein ligase B; Provisional; Region: PRK14341 283165002237 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 283165002238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165002239 ATP binding site [chemical binding]; other site 283165002240 Mg2+ binding site [ion binding]; other site 283165002241 G-X-G motif; other site 283165002242 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 283165002243 anchoring element; other site 283165002244 dimer interface [polypeptide binding]; other site 283165002245 ATP binding site [chemical binding]; other site 283165002246 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 283165002247 active site 283165002248 metal binding site [ion binding]; metal-binding site 283165002249 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 283165002250 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 283165002251 DHH family; Region: DHH; pfam01368 283165002252 DHHA1 domain; Region: DHHA1; pfam02272 283165002253 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 283165002254 23S rRNA interface [nucleotide binding]; other site 283165002255 L3 interface [polypeptide binding]; other site 283165002256 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 283165002257 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 283165002258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165002259 active site 283165002260 phosphorylation site [posttranslational modification] 283165002261 intermolecular recognition site; other site 283165002262 dimerization interface [polypeptide binding]; other site 283165002263 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 283165002264 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 283165002265 Autotransporter beta-domain; Region: Autotransporter; smart00869 283165002266 Identified by comparison to Bartonella henselae;hypothetical protein 283165002267 Identified by comparison to Bartonella henselae;hypothetical protein 283165002268 Identified by comparison to Bartonella henselae;hecB 283165002269 putative proline-specific permease; Provisional; Region: proY; PRK10580 283165002270 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 283165002271 active sites [active] 283165002272 tetramer interface [polypeptide binding]; other site 283165002273 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 283165002274 ATP-NAD kinase; Region: NAD_kinase; pfam01513 283165002275 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 283165002276 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 283165002277 ATP binding site [chemical binding]; other site 283165002278 Mg++ binding site [ion binding]; other site 283165002279 motif III; other site 283165002280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 283165002281 nucleotide binding region [chemical binding]; other site 283165002282 ATP-binding site [chemical binding]; other site 283165002283 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 283165002284 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 283165002285 active site 283165002286 HIGH motif; other site 283165002287 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 283165002288 active site 283165002289 KMSKS motif; other site 283165002290 NAD synthetase; Provisional; Region: PRK13981 283165002291 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 283165002292 multimer interface [polypeptide binding]; other site 283165002293 active site 283165002294 catalytic triad [active] 283165002295 protein interface 1 [polypeptide binding]; other site 283165002296 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 283165002297 homodimer interface [polypeptide binding]; other site 283165002298 NAD binding pocket [chemical binding]; other site 283165002299 ATP binding pocket [chemical binding]; other site 283165002300 Mg binding site [ion binding]; other site 283165002301 active-site loop [active] 283165002302 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 283165002303 glutathione reductase; Validated; Region: PRK06116 283165002304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 283165002305 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 283165002306 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 283165002307 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 283165002308 tetramer (dimer of dimers) interface [polypeptide binding]; other site 283165002309 active site 283165002310 dimer interface [polypeptide binding]; other site 283165002311 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 283165002312 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 283165002313 Competence protein; Region: Competence; pfam03772 283165002314 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 283165002315 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 283165002316 active site 283165002317 HIGH motif; other site 283165002318 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 283165002319 active site 283165002320 KMSKS motif; other site 283165002321 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 283165002322 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 283165002323 dimer interface [polypeptide binding]; other site 283165002324 active site 283165002325 citrylCoA binding site [chemical binding]; other site 283165002326 NADH binding [chemical binding]; other site 283165002327 cationic pore residues; other site 283165002328 oxalacetate/citrate binding site [chemical binding]; other site 283165002329 coenzyme A binding site [chemical binding]; other site 283165002330 catalytic triad [active] 283165002331 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 283165002332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 283165002333 substrate binding pocket [chemical binding]; other site 283165002334 membrane-bound complex binding site; other site 283165002335 hinge residues; other site 283165002336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 283165002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165002338 dimer interface [polypeptide binding]; other site 283165002339 conserved gate region; other site 283165002340 putative PBP binding loops; other site 283165002341 ABC-ATPase subunit interface; other site 283165002342 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 283165002343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165002344 dimer interface [polypeptide binding]; other site 283165002345 conserved gate region; other site 283165002346 putative PBP binding loops; other site 283165002347 ABC-ATPase subunit interface; other site 283165002348 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 283165002349 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 283165002350 Walker A/P-loop; other site 283165002351 ATP binding site [chemical binding]; other site 283165002352 Q-loop/lid; other site 283165002353 ABC transporter signature motif; other site 283165002354 Walker B; other site 283165002355 D-loop; other site 283165002356 H-loop/switch region; other site 283165002357 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 283165002358 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 283165002359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 283165002360 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 283165002361 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 283165002362 active site 283165002363 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 283165002364 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 283165002365 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 283165002366 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 283165002367 trimer interface [polypeptide binding]; other site 283165002368 active site 283165002369 UDP-GlcNAc binding site [chemical binding]; other site 283165002370 lipid binding site [chemical binding]; lipid-binding site 283165002371 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 283165002372 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 283165002373 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 283165002374 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 283165002375 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 283165002376 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 283165002377 Surface antigen; Region: Bac_surface_Ag; pfam01103 283165002378 RIP metalloprotease RseP; Region: TIGR00054 283165002379 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 283165002380 active site 283165002381 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 283165002382 protein binding site [polypeptide binding]; other site 283165002383 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 283165002384 putative substrate binding region [chemical binding]; other site 283165002385 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 283165002386 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 283165002387 ribosome recycling factor; Reviewed; Region: frr; PRK00083 283165002388 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 283165002389 hinge region; other site 283165002390 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 283165002391 putative nucleotide binding site [chemical binding]; other site 283165002392 uridine monophosphate binding site [chemical binding]; other site 283165002393 homohexameric interface [polypeptide binding]; other site 283165002394 elongation factor Ts; Provisional; Region: tsf; PRK09377 283165002395 UBA/TS-N domain; Region: UBA; pfam00627 283165002396 Elongation factor TS; Region: EF_TS; pfam00889 283165002397 Elongation factor TS; Region: EF_TS; pfam00889 283165002398 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 283165002399 rRNA interaction site [nucleotide binding]; other site 283165002400 S8 interaction site; other site 283165002401 putative laminin-1 binding site; other site 283165002402 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 283165002403 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 283165002404 homotrimer interaction site [polypeptide binding]; other site 283165002405 putative active site [active] 283165002406 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 283165002407 HIT family signature motif; other site 283165002408 catalytic residue [active] 283165002409 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 283165002410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165002411 Walker A motif; other site 283165002412 ATP binding site [chemical binding]; other site 283165002413 Walker B motif; other site 283165002414 arginine finger; other site 283165002415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165002416 Walker A motif; other site 283165002417 ATP binding site [chemical binding]; other site 283165002418 Walker B motif; other site 283165002419 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 283165002420 Uncharacterized conserved protein [Function unknown]; Region: COG2127 283165002421 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 283165002422 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 283165002423 Sporulation related domain; Region: SPOR; pfam05036 283165002424 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 283165002425 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 283165002426 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 283165002427 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 283165002428 putative FMN binding site [chemical binding]; other site 283165002429 Identified by comparison to Bartonella henselae;transcriptional regulator 283165002430 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 283165002431 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 283165002432 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 283165002433 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 283165002434 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 283165002435 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 283165002436 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 283165002437 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 283165002438 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 283165002439 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 283165002440 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 283165002441 DNA binding site [nucleotide binding] 283165002442 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 283165002443 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 283165002444 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 283165002445 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 283165002446 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 283165002447 RPB11 interaction site [polypeptide binding]; other site 283165002448 RPB12 interaction site [polypeptide binding]; other site 283165002449 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 283165002450 RPB1 interaction site [polypeptide binding]; other site 283165002451 RPB11 interaction site [polypeptide binding]; other site 283165002452 RPB10 interaction site [polypeptide binding]; other site 283165002453 RPB3 interaction site [polypeptide binding]; other site 283165002454 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 283165002455 L11 interface [polypeptide binding]; other site 283165002456 putative EF-Tu interaction site [polypeptide binding]; other site 283165002457 putative EF-G interaction site [polypeptide binding]; other site 283165002458 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 283165002459 23S rRNA interface [nucleotide binding]; other site 283165002460 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 283165002461 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 283165002462 mRNA/rRNA interface [nucleotide binding]; other site 283165002463 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 283165002464 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 283165002465 23S rRNA interface [nucleotide binding]; other site 283165002466 L7/L12 interface [polypeptide binding]; other site 283165002467 putative thiostrepton binding site; other site 283165002468 L25 interface [polypeptide binding]; other site 283165002469 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 283165002470 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 283165002471 putative homodimer interface [polypeptide binding]; other site 283165002472 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 283165002473 heterodimer interface [polypeptide binding]; other site 283165002474 homodimer interface [polypeptide binding]; other site 283165002475 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 283165002476 elongation factor Tu; Reviewed; Region: PRK00049 283165002477 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 283165002478 G1 box; other site 283165002479 GEF interaction site [polypeptide binding]; other site 283165002480 GTP/Mg2+ binding site [chemical binding]; other site 283165002481 Switch I region; other site 283165002482 G2 box; other site 283165002483 G3 box; other site 283165002484 Switch II region; other site 283165002485 G4 box; other site 283165002486 G5 box; other site 283165002487 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 283165002488 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 283165002489 Antibiotic Binding Site [chemical binding]; other site 283165002490 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 283165002491 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 283165002492 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 283165002493 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 283165002494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 283165002495 NADH dehydrogenase; Validated; Region: PRK08183 283165002496 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 283165002497 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 283165002498 GatB domain; Region: GatB_Yqey; smart00845 283165002499 trigger factor; Provisional; Region: tig; PRK01490 283165002500 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 283165002501 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 283165002502 Identified by comparison to Bartonella henselae;hypothetical genomic island protein 283165002503 Identified by comparison to Bartonella henselae;hypothetical protein 283165002504 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 283165002505 hypothetical protein; Validated; Region: PRK09087 283165002506 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 283165002507 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 283165002508 Domain of unknown function DUF20; Region: UPF0118; pfam01594 283165002509 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 283165002510 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 283165002511 dimerization interface [polypeptide binding]; other site 283165002512 putative ATP binding site [chemical binding]; other site 283165002513 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 283165002514 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 283165002515 active site 283165002516 substrate binding site [chemical binding]; other site 283165002517 cosubstrate binding site; other site 283165002518 catalytic site [active] 283165002519 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 283165002520 PAS fold; Region: PAS_4; pfam08448 283165002521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 283165002522 putative active site [active] 283165002523 heme pocket [chemical binding]; other site 283165002524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 283165002525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 283165002526 dimer interface [polypeptide binding]; other site 283165002527 phosphorylation site [posttranslational modification] 283165002528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 283165002529 ATP binding site [chemical binding]; other site 283165002530 Mg2+ binding site [ion binding]; other site 283165002531 G-X-G motif; other site 283165002532 Response regulator receiver domain; Region: Response_reg; pfam00072 283165002533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165002534 active site 283165002535 phosphorylation site [posttranslational modification] 283165002536 intermolecular recognition site; other site 283165002537 dimerization interface [polypeptide binding]; other site 283165002538 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 283165002539 Flavin Reductases; Region: FlaRed; cl00801 283165002540 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 283165002541 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 283165002542 substrate binding site [chemical binding]; other site 283165002543 hexamer interface [polypeptide binding]; other site 283165002544 metal binding site [ion binding]; metal-binding site 283165002545 adenylosuccinate lyase; Provisional; Region: PRK07492 283165002546 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 283165002547 tetramer interface [polypeptide binding]; other site 283165002548 active site 283165002549 Serine hydrolase; Region: Ser_hydrolase; pfam06821 283165002550 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 283165002551 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 283165002552 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 283165002553 ATP binding site [chemical binding]; other site 283165002554 active site 283165002555 substrate binding site [chemical binding]; other site 283165002556 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 283165002557 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 283165002558 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 283165002559 putative active site [active] 283165002560 catalytic triad [active] 283165002561 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 283165002562 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 283165002563 dimerization interface [polypeptide binding]; other site 283165002564 ATP binding site [chemical binding]; other site 283165002565 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 283165002566 dimerization interface [polypeptide binding]; other site 283165002567 ATP binding site [chemical binding]; other site 283165002568 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 283165002569 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 283165002570 putative GSH binding site [chemical binding]; other site 283165002571 catalytic residues [active] 283165002572 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 283165002573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165002574 putative substrate translocation pore; other site 283165002575 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 283165002576 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 283165002577 CAP-like domain; other site 283165002578 active site 283165002579 primary dimer interface [polypeptide binding]; other site 283165002580 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 283165002581 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 283165002582 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 283165002583 dimer interface [polypeptide binding]; other site 283165002584 anticodon binding site; other site 283165002585 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 283165002586 homodimer interface [polypeptide binding]; other site 283165002587 motif 1; other site 283165002588 active site 283165002589 motif 2; other site 283165002590 GAD domain; Region: GAD; pfam02938 283165002591 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 283165002592 active site 283165002593 motif 3; other site 283165002594 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 283165002595 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 283165002596 catalytic site [active] 283165002597 putative active site [active] 283165002598 putative substrate binding site [chemical binding]; other site 283165002599 HRDC domain; Region: HRDC; pfam00570 283165002600 Identified by comparison to Bartonella henselae;ribonuclease D 283165002601 exopolyphosphatase; Region: exo_poly_only; TIGR03706 283165002602 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 283165002603 polyphosphate kinase; Provisional; Region: PRK05443 283165002604 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 283165002605 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 283165002606 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 283165002607 putative domain interface [polypeptide binding]; other site 283165002608 putative active site [active] 283165002609 catalytic site [active] 283165002610 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 283165002611 putative domain interface [polypeptide binding]; other site 283165002612 putative active site [active] 283165002613 catalytic site [active] 283165002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 283165002615 salicylate hydroxylase; Provisional; Region: PRK06475 283165002616 salicylate hydroxylase; Provisional; Region: PRK08163 283165002617 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 283165002618 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 283165002619 putative active site [active] 283165002620 putative PHP Thumb interface [polypeptide binding]; other site 283165002621 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 283165002622 generic binding surface II; other site 283165002623 generic binding surface I; other site 283165002624 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 283165002625 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 283165002626 generic binding surface II; other site 283165002627 ssDNA binding site; other site 283165002628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 283165002629 ATP binding site [chemical binding]; other site 283165002630 putative Mg++ binding site [ion binding]; other site 283165002631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 283165002632 nucleotide binding region [chemical binding]; other site 283165002633 ATP-binding site [chemical binding]; other site 283165002634 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 283165002635 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 283165002636 glutaminase active site [active] 283165002637 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 283165002638 dimer interface [polypeptide binding]; other site 283165002639 active site 283165002640 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 283165002641 dimer interface [polypeptide binding]; other site 283165002642 active site 283165002643 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 283165002644 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 283165002645 Substrate binding site; other site 283165002646 Mg++ binding site; other site 283165002647 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 283165002648 active site 283165002649 substrate binding site [chemical binding]; other site 283165002650 CoA binding site [chemical binding]; other site 283165002651 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 283165002652 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 283165002653 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 283165002654 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 283165002655 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 283165002656 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 283165002657 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 283165002658 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 283165002659 active site 283165002660 HIGH motif; other site 283165002661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 283165002662 KMSK motif region; other site 283165002663 tRNA binding surface [nucleotide binding]; other site 283165002664 DALR anticodon binding domain; Region: DALR_1; smart00836 283165002665 anticodon binding site; other site 283165002666 Sporulation related domain; Region: SPOR; pfam05036 283165002667 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 283165002668 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 283165002669 homodimer interface [polypeptide binding]; other site 283165002670 substrate-cofactor binding pocket; other site 283165002671 catalytic residue [active] 283165002672 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 283165002673 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 283165002674 putative active site [active] 283165002675 Identified by comparison to Bartonella henselae;homoserine dehydrogenase 283165002676 Identified by comparison to Bartonella henselae;hypothetical protein 283165002677 isocitrate dehydrogenase; Validated; Region: PRK08299 283165002678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165002679 putative substrate translocation pore; other site 283165002680 Identified by comparison to Bartonella henselae;transmembrane transport protein 283165002681 Identified by comparison to Bartonella henselae;queuine trna-ribosyltransferase 283165002682 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 283165002683 active site 283165002684 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 283165002685 active site 283165002686 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 283165002687 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 283165002688 active site 283165002689 (T/H)XGH motif; other site 283165002690 DNA gyrase subunit A; Validated; Region: PRK05560 283165002691 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 283165002692 CAP-like domain; other site 283165002693 active site 283165002694 primary dimer interface [polypeptide binding]; other site 283165002695 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 283165002696 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 283165002697 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 283165002698 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 283165002699 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 283165002700 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 283165002701 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 283165002702 dimer interface [polypeptide binding]; other site 283165002703 ssDNA binding site [nucleotide binding]; other site 283165002704 tetramer (dimer of dimers) interface [polypeptide binding]; other site 283165002705 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 283165002706 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 283165002707 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 283165002708 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 283165002709 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 283165002710 Nitrogen regulatory protein P-II; Region: P-II; smart00938 283165002711 glutamine synthetase; Provisional; Region: glnA; PRK09469 283165002712 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 283165002713 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 283165002714 ATP12 chaperone protein; Region: ATP12; cl02228 283165002715 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 283165002716 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 283165002717 active site 283165002718 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 283165002719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 283165002720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 283165002721 Walker A/P-loop; other site 283165002722 ATP binding site [chemical binding]; other site 283165002723 Q-loop/lid; other site 283165002724 ABC transporter signature motif; other site 283165002725 Walker B; other site 283165002726 D-loop; other site 283165002727 H-loop/switch region; other site 283165002728 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 283165002729 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 283165002730 motif 1; other site 283165002731 active site 283165002732 motif 2; other site 283165002733 motif 3; other site 283165002734 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 283165002735 recombinase A; Provisional; Region: recA; PRK09354 283165002736 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 283165002737 hexamer interface [polypeptide binding]; other site 283165002738 Walker A motif; other site 283165002739 ATP binding site [chemical binding]; other site 283165002740 Walker B motif; other site 283165002741 recombination factor protein RarA; Reviewed; Region: PRK13342 283165002742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165002743 Walker A motif; other site 283165002744 ATP binding site [chemical binding]; other site 283165002745 Walker B motif; other site 283165002746 arginine finger; other site 283165002747 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 283165002748 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 283165002749 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 283165002750 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 283165002751 protein binding site [polypeptide binding]; other site 283165002752 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 283165002753 protein binding site [polypeptide binding]; other site 283165002754 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 283165002755 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 283165002756 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 283165002757 alphaNTD - beta interaction site [polypeptide binding]; other site 283165002758 alphaNTD homodimer interface [polypeptide binding]; other site 283165002759 alphaNTD - beta' interaction site [polypeptide binding]; other site 283165002760 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 283165002761 30S ribosomal protein S11; Validated; Region: PRK05309 283165002762 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 283165002763 30S ribosomal protein S13; Region: bact_S13; TIGR03631 283165002764 adenylate kinase; Reviewed; Region: adk; PRK00279 283165002765 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 283165002766 AMP-binding site [chemical binding]; other site 283165002767 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 283165002768 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 283165002769 SecY translocase; Region: SecY; pfam00344 283165002770 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 283165002771 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 283165002772 23S rRNA binding site [nucleotide binding]; other site 283165002773 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 283165002774 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 283165002775 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 283165002776 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 283165002777 23S rRNA interface [nucleotide binding]; other site 283165002778 5S rRNA interface [nucleotide binding]; other site 283165002779 L27 interface [polypeptide binding]; other site 283165002780 L5 interface [polypeptide binding]; other site 283165002781 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 283165002782 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 283165002783 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 283165002784 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 283165002785 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 283165002786 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 283165002787 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 283165002788 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 283165002789 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 283165002790 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 283165002791 RNA binding site [nucleotide binding]; other site 283165002792 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 283165002793 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 283165002794 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 283165002795 putative translocon interaction site; other site 283165002796 23S rRNA interface [nucleotide binding]; other site 283165002797 signal recognition particle (SRP54) interaction site; other site 283165002798 L23 interface [polypeptide binding]; other site 283165002799 trigger factor interaction site; other site 283165002800 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 283165002801 23S rRNA interface [nucleotide binding]; other site 283165002802 5S rRNA interface [nucleotide binding]; other site 283165002803 putative antibiotic binding site [chemical binding]; other site 283165002804 L25 interface [polypeptide binding]; other site 283165002805 L27 interface [polypeptide binding]; other site 283165002806 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 283165002807 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 283165002808 G-X-X-G motif; other site 283165002809 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 283165002810 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 283165002811 putative translocon binding site; other site 283165002812 protein-rRNA interface [nucleotide binding]; other site 283165002813 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 283165002814 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 283165002815 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 283165002816 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 283165002817 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 283165002818 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 283165002819 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 283165002820 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 283165002821 elongation factor Tu; Reviewed; Region: PRK00049 283165002822 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 283165002823 G1 box; other site 283165002824 GEF interaction site [polypeptide binding]; other site 283165002825 GTP/Mg2+ binding site [chemical binding]; other site 283165002826 Switch I region; other site 283165002827 G2 box; other site 283165002828 G3 box; other site 283165002829 Switch II region; other site 283165002830 G4 box; other site 283165002831 G5 box; other site 283165002832 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 283165002833 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 283165002834 Antibiotic Binding Site [chemical binding]; other site 283165002835 elongation factor G; Reviewed; Region: PRK00007 283165002836 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 283165002837 G1 box; other site 283165002838 putative GEF interaction site [polypeptide binding]; other site 283165002839 GTP/Mg2+ binding site [chemical binding]; other site 283165002840 Switch I region; other site 283165002841 G2 box; other site 283165002842 G3 box; other site 283165002843 Switch II region; other site 283165002844 G4 box; other site 283165002845 G5 box; other site 283165002846 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 283165002847 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 283165002848 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 283165002849 30S ribosomal protein S7; Validated; Region: PRK05302 283165002850 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 283165002851 S17 interaction site [polypeptide binding]; other site 283165002852 S8 interaction site; other site 283165002853 16S rRNA interaction site [nucleotide binding]; other site 283165002854 streptomycin interaction site [chemical binding]; other site 283165002855 23S rRNA interaction site [nucleotide binding]; other site 283165002856 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 283165002857 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 283165002858 putative catalytic site [active] 283165002859 putative phosphate binding site [ion binding]; other site 283165002860 active site 283165002861 metal binding site A [ion binding]; metal-binding site 283165002862 DNA binding site [nucleotide binding] 283165002863 putative AP binding site [nucleotide binding]; other site 283165002864 putative metal binding site B [ion binding]; other site 283165002865 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 283165002866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 283165002867 substrate binding pocket [chemical binding]; other site 283165002868 membrane-bound complex binding site; other site 283165002869 hinge residues; other site 283165002870 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 283165002871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165002872 dimer interface [polypeptide binding]; other site 283165002873 conserved gate region; other site 283165002874 putative PBP binding loops; other site 283165002875 ABC-ATPase subunit interface; other site 283165002876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165002877 dimer interface [polypeptide binding]; other site 283165002878 conserved gate region; other site 283165002879 putative PBP binding loops; other site 283165002880 ABC-ATPase subunit interface; other site 283165002881 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 283165002882 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 283165002883 Walker A/P-loop; other site 283165002884 ATP binding site [chemical binding]; other site 283165002885 Q-loop/lid; other site 283165002886 ABC transporter signature motif; other site 283165002887 Walker B; other site 283165002888 D-loop; other site 283165002889 H-loop/switch region; other site 283165002890 Identified by comparison to Bartonella henselae;exopolysaccharide regulatory protein 283165002891 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 283165002892 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 283165002893 HIGH motif; other site 283165002894 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 283165002895 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 283165002896 active site 283165002897 KMSKS motif; other site 283165002898 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 283165002899 tRNA binding surface [nucleotide binding]; other site 283165002900 anticodon binding site; other site 283165002901 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 283165002902 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 283165002903 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 283165002904 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 283165002905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165002906 S-adenosylmethionine binding site [chemical binding]; other site 283165002907 Identified by comparison to Bartonella henselae;ilvA threonine dehydratase 283165002908 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 283165002909 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 283165002910 Mechanosensitive ion channel; Region: MS_channel; pfam00924 283165002911 hypothetical protein;Identified by comparison to Bartonella henselae 283165002912 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 283165002913 Protein export membrane protein; Region: SecD_SecF; cl14618 283165002914 Protein export membrane protein; Region: SecD_SecF; pfam02355 283165002915 putative cation:proton antiport protein; Provisional; Region: PRK10669 283165002916 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 283165002917 TrkA-N domain; Region: TrkA_N; pfam02254 283165002918 Predicted integral membrane protein [Function unknown]; Region: COG0392 283165002919 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 283165002920 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 283165002921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 283165002922 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 283165002923 Transporter associated domain; Region: CorC_HlyC; smart01091 283165002924 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 283165002925 ketol-acid reductoisomerase; Provisional; Region: PRK05479 283165002926 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 283165002927 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 283165002928 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 283165002929 active site 283165002930 hydrophilic channel; other site 283165002931 dimerization interface [polypeptide binding]; other site 283165002932 catalytic residues [active] 283165002933 active site lid [active] 283165002934 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 283165002935 AAA domain; Region: AAA_30; pfam13604 283165002936 Family description; Region: UvrD_C_2; pfam13538 283165002937 Identified by comparison to Bartonella henselae;ilvB 283165002938 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 283165002939 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 283165002940 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 283165002941 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 283165002942 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 283165002943 protein binding site [polypeptide binding]; other site 283165002944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 283165002945 protein binding site [polypeptide binding]; other site 283165002946 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 283165002947 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 283165002948 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 283165002949 HflK protein; Region: hflK; TIGR01933 283165002950 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 283165002951 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 283165002952 folate binding site [chemical binding]; other site 283165002953 NADP+ binding site [chemical binding]; other site 283165002954 thymidylate synthase; Reviewed; Region: thyA; PRK01827 283165002955 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 283165002956 dimerization interface [polypeptide binding]; other site 283165002957 active site 283165002958 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 283165002959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165002960 putative substrate translocation pore; other site 283165002961 Identified by comparison to Bartonella quintana;thyA 283165002962 Identified by comparison to Bartonella henselae;alpha-ketoglutarate permease 283165002963 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 283165002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 283165002965 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 283165002966 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 283165002967 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 283165002968 Part of AAA domain; Region: AAA_19; pfam13245 283165002969 Family description; Region: UvrD_C_2; pfam13538 283165002970 Identified by comparison to Bartonella henselae;chloramphenicol acetyltransferase 283165002971 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 283165002972 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 283165002973 Cu(I) binding site [ion binding]; other site 283165002974 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 283165002975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165002976 S-adenosylmethionine binding site [chemical binding]; other site 283165002977 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 283165002978 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 283165002979 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 283165002980 active site 283165002981 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 283165002982 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 283165002983 nucleotide binding pocket [chemical binding]; other site 283165002984 K-X-D-G motif; other site 283165002985 catalytic site [active] 283165002986 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 283165002987 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 283165002988 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 283165002989 Dimer interface [polypeptide binding]; other site 283165002990 BRCT sequence motif; other site 283165002991 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 283165002992 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 283165002993 Walker A/P-loop; other site 283165002994 ATP binding site [chemical binding]; other site 283165002995 Q-loop/lid; other site 283165002996 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 283165002997 ABC transporter signature motif; other site 283165002998 Walker B; other site 283165002999 D-loop; other site 283165003000 H-loop/switch region; other site 283165003001 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 283165003002 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 283165003003 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 283165003004 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 283165003005 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 283165003006 nucleotide binding site [chemical binding]; other site 283165003007 SulA interaction site; other site 283165003008 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 283165003009 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 283165003010 Cell division protein FtsA; Region: FtsA; smart00842 283165003011 Cell division protein FtsA; Region: FtsA; pfam14450 283165003012 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 283165003013 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 283165003014 Cell division protein FtsQ; Region: FtsQ; pfam03799 283165003015 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 283165003016 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 283165003017 ATP-grasp domain; Region: ATP-grasp_4; cl17255 283165003018 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 283165003019 FAD binding domain; Region: FAD_binding_4; pfam01565 283165003020 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 283165003021 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 283165003022 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 283165003023 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 283165003024 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 283165003025 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 283165003026 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 283165003027 active site 283165003028 homodimer interface [polypeptide binding]; other site 283165003029 cell division protein FtsW; Region: ftsW; TIGR02614 283165003030 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 283165003031 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 283165003032 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 283165003033 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 283165003034 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 283165003035 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 283165003036 Mg++ binding site [ion binding]; other site 283165003037 putative catalytic motif [active] 283165003038 putative substrate binding site [chemical binding]; other site 283165003039 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 283165003040 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 283165003041 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 283165003042 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 283165003043 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 283165003044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 283165003045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 283165003046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 283165003047 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 283165003048 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 283165003049 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 283165003050 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 283165003051 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 283165003052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165003053 S-adenosylmethionine binding site [chemical binding]; other site 283165003054 Identified by comparison to Brucella melitensis;hypothetical protein 283165003055 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 283165003056 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 283165003057 N-acetyl-D-glucosamine binding site [chemical binding]; other site 283165003058 catalytic residue [active] 283165003059 Identified by comparison to Bartonella henselae;regulatory protein 283165003060 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 283165003061 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 283165003062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 283165003063 ABC transporter; Region: ABC_tran_2; pfam12848 283165003064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 283165003065 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 283165003066 Isochorismatase family; Region: Isochorismatase; pfam00857 283165003067 catalytic triad [active] 283165003068 metal binding site [ion binding]; metal-binding site 283165003069 conserved cis-peptide bond; other site 283165003070 hypothetical protein; Provisional; Region: PRK14013 283165003071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 283165003072 non-specific DNA binding site [nucleotide binding]; other site 283165003073 salt bridge; other site 283165003074 sequence-specific DNA binding site [nucleotide binding]; other site 283165003075 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 283165003076 Identified by comparison to Bartonella henselae;hypothetical protein 283165003077 Identified by comparison to Bartonella henselae;hypothetical protein 283165003078 Identified by comparison to Bartonella henselae;phage related protein 283165003079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 283165003080 non-specific DNA binding site [nucleotide binding]; other site 283165003081 salt bridge; other site 283165003082 sequence-specific DNA binding site [nucleotide binding]; other site 283165003083 Identified by comparison to Bartonella henselae;anti-repressor 283165003084 Identified by comparison to Bartonella henselae;integrase/recombinase 283165003085 Uncharacterized conserved protein [Function unknown]; Region: COG2968 283165003086 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 283165003087 Identified by comparison to Bartonella henselae;hypothetical protein 283165003088 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 283165003089 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 283165003090 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 283165003091 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 283165003092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 283165003093 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 283165003094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 283165003095 DNA binding residues [nucleotide binding] 283165003096 DNA primase; Validated; Region: dnaG; PRK05667 283165003097 CHC2 zinc finger; Region: zf-CHC2; cl17510 283165003098 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 283165003099 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 283165003100 active site 283165003101 metal binding site [ion binding]; metal-binding site 283165003102 interdomain interaction site; other site 283165003103 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 283165003104 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 283165003105 Mechanosensitive ion channel; Region: MS_channel; pfam00924 283165003106 Identified by comparison to Bartonella henselae;hypothetical protein 283165003107 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 283165003108 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 283165003109 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 283165003110 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 283165003111 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 283165003112 catalytic site [active] 283165003113 subunit interface [polypeptide binding]; other site 283165003114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165003115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 283165003116 putative substrate translocation pore; other site 283165003117 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 283165003118 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 283165003119 ATP-grasp domain; Region: ATP-grasp_4; cl17255 283165003120 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 283165003121 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 283165003122 ATP-grasp domain; Region: ATP-grasp_4; cl17255 283165003123 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 283165003124 IMP binding site; other site 283165003125 dimer interface [polypeptide binding]; other site 283165003126 interdomain contacts; other site 283165003127 partial ornithine binding site; other site 283165003128 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 283165003129 DNA-binding site [nucleotide binding]; DNA binding site 283165003130 RNA-binding motif; other site 283165003131 aspartate aminotransferase; Provisional; Region: PRK05764 283165003132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 283165003133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 283165003134 homodimer interface [polypeptide binding]; other site 283165003135 catalytic residue [active] 283165003136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 283165003137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 283165003138 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 283165003139 putative effector binding pocket; other site 283165003140 dimerization interface [polypeptide binding]; other site 283165003141 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 283165003142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 283165003143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 283165003144 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 283165003145 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 283165003146 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 283165003147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 283165003148 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 283165003149 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 283165003150 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 283165003151 Bacterial SH3 domain; Region: SH3_3; pfam08239 283165003152 excinuclease ABC subunit B; Provisional; Region: PRK05298 283165003153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 283165003154 ATP binding site [chemical binding]; other site 283165003155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 283165003156 nucleotide binding region [chemical binding]; other site 283165003157 ATP-binding site [chemical binding]; other site 283165003158 Ultra-violet resistance protein B; Region: UvrB; pfam12344 283165003159 UvrB/uvrC motif; Region: UVR; pfam02151 283165003160 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 283165003161 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 283165003162 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 283165003163 active site 283165003164 NTP binding site [chemical binding]; other site 283165003165 metal binding triad [ion binding]; metal-binding site 283165003166 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 283165003167 MoxR-like ATPases [General function prediction only]; Region: COG0714 283165003168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165003169 Walker A motif; other site 283165003170 ATP binding site [chemical binding]; other site 283165003171 Walker B motif; other site 283165003172 arginine finger; other site 283165003173 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 283165003174 Protein of unknown function DUF58; Region: DUF58; pfam01882 283165003175 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 283165003176 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 283165003177 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 283165003178 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 283165003179 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 283165003180 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 283165003181 putative active site [active] 283165003182 putative metal binding site [ion binding]; other site 283165003183 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 283165003184 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 283165003185 Cation efflux family; Region: Cation_efflux; pfam01545 283165003186 Identified by comparison to Brucella melitensis;23s rRNA methyltransferase 283165003187 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 283165003188 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 283165003189 Ligand Binding Site [chemical binding]; other site 283165003190 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 283165003191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 283165003192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165003193 active site 283165003194 phosphorylation site [posttranslational modification] 283165003195 intermolecular recognition site; other site 283165003196 dimerization interface [polypeptide binding]; other site 283165003197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 283165003198 DNA binding site [nucleotide binding] 283165003199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 283165003200 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 283165003201 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 283165003202 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 283165003203 inhibitor-cofactor binding pocket; inhibition site 283165003204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 283165003205 catalytic residue [active] 283165003206 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 283165003207 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 283165003208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 283165003209 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 283165003210 Walker A/P-loop; other site 283165003211 ATP binding site [chemical binding]; other site 283165003212 Q-loop/lid; other site 283165003213 ABC transporter signature motif; other site 283165003214 Walker B; other site 283165003215 D-loop; other site 283165003216 H-loop/switch region; other site 283165003217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 283165003218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 283165003219 Walker A/P-loop; other site 283165003220 ATP binding site [chemical binding]; other site 283165003221 Q-loop/lid; other site 283165003222 ABC transporter signature motif; other site 283165003223 Walker B; other site 283165003224 D-loop; other site 283165003225 H-loop/switch region; other site 283165003226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 283165003227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 283165003228 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 283165003229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 283165003230 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 283165003231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 283165003232 dimer interface [polypeptide binding]; other site 283165003233 conserved gate region; other site 283165003234 putative PBP binding loops; other site 283165003235 ABC-ATPase subunit interface; other site 283165003236 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 283165003237 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 283165003238 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 283165003239 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 283165003240 Identified by comparison to Bartonella henselae;abc transporter periplasmic ol 283165003241 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 283165003242 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 283165003243 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 283165003244 generic binding surface II; other site 283165003245 generic binding surface I; other site 283165003246 Identified by comparison to Bartonella henselae;xsea 283165003247 Identified by comparison to Bartonella henselae;hypothetical protein 283165003248 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 283165003249 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 283165003250 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 283165003251 Ligand binding site [chemical binding]; other site 283165003252 Electron transfer flavoprotein domain; Region: ETF; pfam01012 283165003253 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 283165003254 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 283165003255 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 283165003256 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 283165003257 hydroxyglutarate oxidase; Provisional; Region: PRK11728 283165003258 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 283165003259 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 283165003260 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 283165003261 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 283165003262 hypothetical protein; Reviewed; Region: PRK12497 283165003263 Predicted methyltransferases [General function prediction only]; Region: COG0313 283165003264 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 283165003265 putative SAM binding site [chemical binding]; other site 283165003266 putative homodimer interface [polypeptide binding]; other site 283165003267 Identified by comparison to Mesorhizobium loti;orotidine 5`-phosphate decarboxylase 283165003268 Domain of unknown function DUF59; Region: DUF59; pfam01883 283165003269 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 283165003270 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 283165003271 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 283165003272 ribonuclease P; Reviewed; Region: rnpA; PRK01313 283165003273 membrane protein insertase; Provisional; Region: PRK01318 283165003274 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 283165003275 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 283165003276 G1 box; other site 283165003277 GTP/Mg2+ binding site [chemical binding]; other site 283165003278 Switch I region; other site 283165003279 G2 box; other site 283165003280 G3 box; other site 283165003281 Switch II region; other site 283165003282 G4 box; other site 283165003283 G5 box; other site 283165003284 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 283165003285 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 283165003286 C-terminal domain interface [polypeptide binding]; other site 283165003287 GSH binding site (G-site) [chemical binding]; other site 283165003288 dimer interface [polypeptide binding]; other site 283165003289 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 283165003290 N-terminal domain interface [polypeptide binding]; other site 283165003291 dimer interface [polypeptide binding]; other site 283165003292 substrate binding pocket (H-site) [chemical binding]; other site 283165003293 dihydrodipicolinate reductase; Provisional; Region: PRK00048 283165003294 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 283165003295 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 283165003296 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 283165003297 catalytic core [active] 283165003298 Identified by comparison to Bartonella henselae;mccB 283165003299 Identified by comparison to Bartonella henselae;mccC 283165003300 Identified by comparison to Bartonella henselae;integrase/recombinase 283165003301 Porin subfamily; Region: Porin_2; pfam02530 283165003302 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 283165003303 substrate binding site [chemical binding]; other site 283165003304 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 283165003305 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 283165003306 amidase catalytic site [active] 283165003307 Zn binding residues [ion binding]; other site 283165003308 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 283165003309 Identified by comparison to Bartonella henselae;hypothetical protein 283165003310 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 283165003311 metal binding site 2 [ion binding]; metal-binding site 283165003312 putative DNA binding helix; other site 283165003313 dimer interface [polypeptide binding]; other site 283165003314 structural Zn2+ binding site [ion binding]; other site 283165003315 metal binding site 1 [ion binding]; metal-binding site 283165003316 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 283165003317 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 283165003318 HlyD family secretion protein; Region: HlyD_3; pfam13437 283165003319 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 283165003320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 283165003321 putative substrate translocation pore; other site 283165003322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 283165003323 Coenzyme A binding pocket [chemical binding]; other site 283165003324 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 283165003325 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 283165003326 dimer interface [polypeptide binding]; other site 283165003327 active site 283165003328 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 283165003329 catalytic residues [active] 283165003330 substrate binding site [chemical binding]; other site 283165003331 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 283165003332 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 283165003333 active site residue [active] 283165003334 Identified by comparison to Bartonella henselae;eda 2-keto-3-deoxy-6-phosphogluconate aldolase 283165003335 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 283165003336 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 283165003337 FAD binding pocket [chemical binding]; other site 283165003338 FAD binding motif [chemical binding]; other site 283165003339 phosphate binding motif [ion binding]; other site 283165003340 beta-alpha-beta structure motif; other site 283165003341 NAD binding pocket [chemical binding]; other site 283165003342 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 283165003343 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 283165003344 active site 283165003345 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 283165003346 dimer interface [polypeptide binding]; other site 283165003347 substrate binding site [chemical binding]; other site 283165003348 catalytic residues [active] 283165003349 glycine dehydrogenase; Provisional; Region: PRK05367 283165003350 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 283165003351 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 283165003352 catalytic residue [active] 283165003353 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 283165003354 tetramer interface [polypeptide binding]; other site 283165003355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 283165003356 catalytic residue [active] 283165003357 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 283165003358 lipoyl attachment site [posttranslational modification]; other site 283165003359 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 283165003360 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 283165003361 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 283165003362 Uncharacterized conserved protein [Function unknown]; Region: COG2835 283165003363 Identified by comparison to Bartonella henselae;dna-binding protein 283165003364 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 283165003365 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 283165003366 Bacterial SH3 domain; Region: SH3_3; pfam08239 283165003367 Identified by comparison to Bartonella henselae;yaeC lipoprotein 283165003368 Identified by comparison to Bartonella henselae;abc transporter atp-binding protein 283165003369 Identified by comparison to Bartonella henselae;abc transporter permease 283165003370 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 283165003371 putative active site [active] 283165003372 putative catalytic site [active] 283165003373 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 283165003374 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 283165003375 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 283165003376 Identified by comparison to Bartonella henselae;prophage integrase 283165003377 Creatinine amidohydrolase; Region: Creatininase; pfam02633 283165003378 Identified by comparison to Bartonella henselae;hypothetical protein 283165003379 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 283165003380 Autotransporter beta-domain; Region: Autotransporter; smart00869 283165003381 Autotransporter beta-domain; Region: Autotransporter; smart00869 283165003382 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 283165003383 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 283165003384 putative ligand binding residues [chemical binding]; other site 283165003385 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 283165003386 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 283165003387 ABC-ATPase subunit interface; other site 283165003388 dimer interface [polypeptide binding]; other site 283165003389 putative PBP binding regions; other site 283165003390 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 283165003391 ABC-ATPase subunit interface; other site 283165003392 dimer interface [polypeptide binding]; other site 283165003393 putative PBP binding regions; other site 283165003394 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 283165003395 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 283165003396 Walker A/P-loop; other site 283165003397 ATP binding site [chemical binding]; other site 283165003398 Q-loop/lid; other site 283165003399 ABC transporter signature motif; other site 283165003400 Walker B; other site 283165003401 D-loop; other site 283165003402 H-loop/switch region; other site 283165003403 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 283165003404 Identified by comparison to Bartonella henselae;hypothetical protein 283165003405 Identified by comparison to Bartonella henselae;hypothetical protein 283165003406 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 283165003407 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 283165003408 Autotransporter beta-domain; Region: Autotransporter; smart00869 283165003409 Identified by comparison to Bartonella henselae;hypothetical protein 283165003410 Identified by comparison to Bartonella henselae;probable surface protein 283165003411 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 283165003412 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 283165003413 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 283165003414 Autotransporter beta-domain; Region: Autotransporter; smart00869 283165003415 Identified by comparison to Bartonella henselae;prophage integrase 283165003416 Identified by comparison to Bartonella henselae;abc transporter atp-binding protein 283165003417 Putative phosphatase (DUF442); Region: DUF442; cl17385 283165003418 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 283165003419 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 283165003420 active site 283165003421 Riboflavin kinase; Region: Flavokinase; smart00904 283165003422 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 283165003423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 283165003424 active site 283165003425 motif I; other site 283165003426 motif II; other site 283165003427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 283165003428 motif II; other site 283165003429 Identified by comparison to Bartonella henselae;hypothetical protein 283165003430 hypothetical protein; Provisional; Region: PRK06518 283165003431 Staphylococcal nuclease homologues; Region: SNc; smart00318 283165003432 Catalytic site; other site 283165003433 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003434 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 283165003435 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 283165003436 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 283165003437 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 283165003438 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 283165003439 VirB8 protein; Region: VirB8; cl01500 283165003440 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 283165003441 VirB7 interaction site; other site 283165003442 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 283165003443 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 283165003444 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 283165003445 Walker A motif; other site 283165003446 hexamer interface [polypeptide binding]; other site 283165003447 ATP binding site [chemical binding]; other site 283165003448 Walker B motif; other site 283165003449 Identified by comparison to Bartonella henselae; cell filamentation protein 283165003450 Ti-type conjugative transfer system protein TraG; Region: TraG-Ti; TIGR02767 283165003451 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 283165003452 Walker A motif; other site 283165003453 ATP binding site [chemical binding]; other site 283165003454 Walker B motif; other site 283165003455 Fic/DOC family; Region: Fic; cl00960 283165003456 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 283165003457 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 283165003458 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 283165003459 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 283165003460 active site 283165003461 HIGH motif; other site 283165003462 dimer interface [polypeptide binding]; other site 283165003463 KMSKS motif; other site 283165003464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 283165003465 Ligand Binding Site [chemical binding]; other site 283165003466 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 283165003467 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 283165003468 Identified by comparison to Bartonella henselae;hypothetical protein 283165003469 Identified by comparison to Bartonella henselae;hypothetical protein 283165003470 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 283165003471 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 283165003472 ring oligomerisation interface [polypeptide binding]; other site 283165003473 ATP/Mg binding site [chemical binding]; other site 283165003474 stacking interactions; other site 283165003475 hinge regions; other site 283165003476 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 283165003477 oligomerisation interface [polypeptide binding]; other site 283165003478 mobile loop; other site 283165003479 roof hairpin; other site 283165003480 fumarate hydratase; Reviewed; Region: fumC; PRK00485 283165003481 Class II fumarases; Region: Fumarase_classII; cd01362 283165003482 active site 283165003483 tetramer interface [polypeptide binding]; other site 283165003484 Identified by comparison to Bartonella henselae;phosphoglucomutase 283165003485 phosphoglucomutase; Region: PLN02307 283165003486 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 283165003487 substrate binding site [chemical binding]; other site 283165003488 dimer interface [polypeptide binding]; other site 283165003489 active site 283165003490 metal binding site [ion binding]; metal-binding site 283165003491 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 283165003492 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 283165003493 catalytic triad [active] 283165003494 dimer interface [polypeptide binding]; other site 283165003495 Identified by comparison to Bartonella henselae;hypothetical protein 283165003496 Identified by comparison to Mesorhizobium loti;transposase 283165003497 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 283165003498 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 283165003499 dimer interface [polypeptide binding]; other site 283165003500 motif 1; other site 283165003501 motif 2; other site 283165003502 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 283165003503 active site 283165003504 motif 3; other site 283165003505 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 283165003506 anticodon binding site; other site 283165003507 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 283165003508 active site 283165003509 dimer interface [polypeptide binding]; other site 283165003510 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 283165003511 Identified by comparison to Bartonella henselae;hypothetical protein 283165003512 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 283165003513 Peptidase family M23; Region: Peptidase_M23; pfam01551 283165003514 Identified by comparison to Bartonella henselae;vceA 283165003515 CHASE3 domain; Region: CHASE3; cl05000 283165003516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 283165003517 Histidine kinase; Region: HisKA_2; pfam07568 283165003518 ATP binding site [chemical binding]; other site 283165003519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 283165003520 Mg2+ binding site [ion binding]; other site 283165003521 G-X-G motif; other site 283165003522 RNA polymerase sigma factor; Provisional; Region: PRK12547 283165003523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 283165003524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 283165003525 DNA binding residues [nucleotide binding] 283165003526 two-component response regulator; Provisional; Region: PRK09191 283165003527 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 283165003528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165003529 active site 283165003530 phosphorylation site [posttranslational modification] 283165003531 intermolecular recognition site; other site 283165003532 dimerization interface [polypeptide binding]; other site 283165003533 PAS fold; Region: PAS_4; pfam08448 283165003534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 283165003535 HWE histidine kinase; Region: HWE_HK; pfam07536 283165003536 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 283165003537 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 283165003538 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 283165003539 Phage Tail Collar Domain; Region: Collar; pfam07484 283165003540 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 283165003541 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 283165003542 Phage terminase large subunit; Region: Terminase_3; cl12054 283165003543 Identified by comparison to Bartonella henselae;hypothetical protein 283165003544 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 283165003545 Clp amino terminal domain; Region: Clp_N; pfam02861 283165003546 Clp amino terminal domain; Region: Clp_N; pfam02861 283165003547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165003548 Walker A motif; other site 283165003549 ATP binding site [chemical binding]; other site 283165003550 Walker B motif; other site 283165003551 arginine finger; other site 283165003552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165003553 Walker A motif; other site 283165003554 ATP binding site [chemical binding]; other site 283165003555 Walker B motif; other site 283165003556 arginine finger; other site 283165003557 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 283165003558 zinc-binding protein; Provisional; Region: PRK01343 283165003559 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 283165003560 active site 283165003561 dimer interface [polypeptide binding]; other site 283165003562 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 283165003563 rRNA binding site [nucleotide binding]; other site 283165003564 predicted 30S ribosome binding site; other site 283165003565 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 283165003566 Identified by comparison to Bartonella henselae;hypothetical protein 283165003567 Identified by comparison to Bartonella henselae;hypothetical protein 283165003568 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 283165003569 Identified by comparison to Bartonella henselae;hypothetical protein 283165003570 Identified by comparison to Bartonella henselae;hypothetical protein 283165003571 Identified by comparison to Bartonella henselae;hypothetical protein 283165003572 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 283165003573 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 283165003574 ATP-grasp domain; Region: ATP-grasp; pfam02222 283165003575 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 283165003576 TPR repeat; Region: TPR_11; pfam13414 283165003577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 283165003578 TPR motif; other site 283165003579 TPR repeat; Region: TPR_11; pfam13414 283165003580 binding surface 283165003581 Identified by comparison to Brucella melitensis;hypothetical protein 283165003582 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 283165003583 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 283165003584 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 283165003585 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 283165003586 putative active site [active] 283165003587 metal binding site [ion binding]; metal-binding site 283165003588 homodimer binding site [polypeptide binding]; other site 283165003589 Identified by comparison to Bartonella henselae;hypothetical protein 283165003590 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 283165003591 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 283165003592 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 283165003593 hinge; other site 283165003594 active site 283165003595 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 283165003596 Identified by comparison to Bartonella henselae;hypothetical protein 283165003597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 283165003598 Identified by comparison to Bartonella henselae;hypothetical protein 283165003599 Protein of unknown function (DUF1376); Region: DUF1376; pfam07120 283165003600 ribonuclease E; Reviewed; Region: rne; PRK10811 283165003601 Cytoplasmic activation/proliferation-associated protein-1 C term; Region: Caprin-1_C; pfam12287 283165003602 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 283165003603 active site 283165003604 metal binding site [ion binding]; metal-binding site 283165003605 interdomain interaction site; other site 283165003606 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 283165003607 AAA domain; Region: AAA_25; pfam13481 283165003608 Walker A motif; other site 283165003609 ATP binding site [chemical binding]; other site 283165003610 Walker B motif; other site 283165003611 Identified by comparison to Bartonella henselae;hypothetical protein 283165003612 Identified by comparison to Bartonella henselae;single-stranded binding protein 283165003613 Identified by comparison to Bartonella henselae;hypothetical protein 283165003614 effector protein YopJ; Provisional; Region: PRK15371 283165003615 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 283165003616 catalytic residues [active] 283165003617 Identified by comparison to Bartonella henselae;hypothetical protein 283165003618 Identified by comparison to Bartonella henselae;hypothetical protein 283165003619 Identified by comparison to Bartonella henselae;hypothetical protein 283165003620 Predicted membrane protein [Function unknown]; Region: COG1238 283165003621 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 283165003622 CCC1-related protein family; Region: CCC1_like_1; cd02437 283165003623 Uncharacterized conserved protein [Function unknown]; Region: COG1633 283165003624 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 283165003625 trimer interface [polypeptide binding]; other site 283165003626 active site 283165003627 Identified by comparison to Bartonella quintana;deoxyuridine 5 27-triphosphate nucleotidohydrolase 283165003628 Identified by comparison to Bartonella quintana;deoxyuridine 5 27-triphosphate nucleotidohydrolase 283165003629 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 283165003630 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 283165003631 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 283165003632 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 283165003633 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 283165003634 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 283165003635 active site 283165003636 substrate binding site [chemical binding]; other site 283165003637 metal binding site [ion binding]; metal-binding site 283165003638 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 283165003639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165003640 Walker A motif; other site 283165003641 ATP binding site [chemical binding]; other site 283165003642 Walker B motif; other site 283165003643 arginine finger; other site 283165003644 Peptidase family M41; Region: Peptidase_M41; pfam01434 283165003645 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 283165003646 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 283165003647 Ligand Binding Site [chemical binding]; other site 283165003648 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 283165003649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 283165003650 ligand binding site [chemical binding]; other site 283165003651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 283165003652 hypothetical protein; Validated; Region: PRK00110 283165003653 Identified by comparison to Bartonella henselae;traG 283165003654 Identified by comparison to Escherichia coli; virulence protein 283165003655 translocation protein TolB; Provisional; Region: tolB; PRK05137 283165003656 TolB amino-terminal domain; Region: TolB_N; pfam04052 283165003657 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 283165003658 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 283165003659 ribonuclease E; Reviewed; Region: rne; PRK10811 283165003660 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 283165003661 TolR protein; Region: tolR; TIGR02801 283165003662 TolQ protein; Region: tolQ; TIGR02796 283165003663 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 283165003664 active site 283165003665 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 283165003666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 283165003667 Walker A motif; other site 283165003668 ATP binding site [chemical binding]; other site 283165003669 Walker B motif; other site 283165003670 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 283165003671 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 283165003672 RuvA N terminal domain; Region: RuvA_N; pfam01330 283165003673 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 283165003674 active site 283165003675 putative DNA-binding cleft [nucleotide binding]; other site 283165003676 dimer interface [polypeptide binding]; other site 283165003677 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 283165003678 OpgC protein; Region: OpgC_C; pfam10129 283165003679 Acyltransferase family; Region: Acyl_transf_3; pfam01757 283165003680 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 283165003681 active site 283165003682 thiamine phosphate binding site [chemical binding]; other site 283165003683 pyrophosphate binding site [ion binding]; other site 283165003684 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 283165003685 elongation factor P; Validated; Region: PRK00529 283165003686 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 283165003687 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 283165003688 RNA binding site [nucleotide binding]; other site 283165003689 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 283165003690 RNA binding site [nucleotide binding]; other site 283165003691 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 283165003692 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 283165003693 active site 283165003694 dimerization interface [polypeptide binding]; other site 283165003695 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 283165003696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 283165003697 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 283165003698 Walker A/P-loop; other site 283165003699 ATP binding site [chemical binding]; other site 283165003700 Q-loop/lid; other site 283165003701 ABC transporter signature motif; other site 283165003702 Walker B; other site 283165003703 D-loop; other site 283165003704 H-loop/switch region; other site 283165003705 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 283165003706 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 283165003707 active site 283165003708 intersubunit interface [polypeptide binding]; other site 283165003709 catalytic residue [active] 283165003710 Phosphoglycerate kinase; Region: PGK; pfam00162 283165003711 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 283165003712 substrate binding site [chemical binding]; other site 283165003713 hinge regions; other site 283165003714 ADP binding site [chemical binding]; other site 283165003715 catalytic site [active] 283165003716 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 283165003717 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 283165003718 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 283165003719 Identified by comparison to Bartonella quintana;glyceraldehyde 3-phosphate dehydrogenase 283165003720 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 283165003721 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 283165003722 TPP-binding site [chemical binding]; other site 283165003723 dimer interface [polypeptide binding]; other site 283165003724 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 283165003725 PYR/PP interface [polypeptide binding]; other site 283165003726 dimer interface [polypeptide binding]; other site 283165003727 TPP binding site [chemical binding]; other site 283165003728 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 283165003729 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 283165003730 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 283165003731 Identified by comparison to Mesorhizobium loti;pyruvate kinase 283165003732 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 283165003733 hypothetical protein; Provisional; Region: PRK13694 283165003734 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 283165003735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 283165003736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 283165003737 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 283165003738 Thiamine pyrophosphokinase; Region: TPK; cd07995 283165003739 active site 283165003740 dimerization interface [polypeptide binding]; other site 283165003741 thiamine binding site [chemical binding]; other site 283165003742 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 283165003743 Peptidase family M48; Region: Peptidase_M48; cl12018 283165003744 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 283165003745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 283165003746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 283165003747 DNA binding residues [nucleotide binding] 283165003748 Ferredoxin [Energy production and conversion]; Region: COG1146 283165003749 4Fe-4S binding domain; Region: Fer4; pfam00037 283165003750 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 283165003751 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 283165003752 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 283165003753 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 283165003754 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 283165003755 substrate binding pocket [chemical binding]; other site 283165003756 chain length determination region; other site 283165003757 substrate-Mg2+ binding site; other site 283165003758 catalytic residues [active] 283165003759 aspartate-rich region 1; other site 283165003760 active site lid residues [active] 283165003761 aspartate-rich region 2; other site 283165003762 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 283165003763 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 283165003764 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 283165003765 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 283165003766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 283165003767 HlyD family secretion protein; Region: HlyD_3; pfam13437 283165003768 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 283165003769 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 283165003770 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 283165003771 gamma subunit interface [polypeptide binding]; other site 283165003772 epsilon subunit interface [polypeptide binding]; other site 283165003773 LBP interface [polypeptide binding]; other site 283165003774 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 283165003775 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 283165003776 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 283165003777 alpha subunit interaction interface [polypeptide binding]; other site 283165003778 Walker A motif; other site 283165003779 ATP binding site [chemical binding]; other site 283165003780 Walker B motif; other site 283165003781 inhibitor binding site; inhibition site 283165003782 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 283165003783 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 283165003784 core domain interface [polypeptide binding]; other site 283165003785 delta subunit interface [polypeptide binding]; other site 283165003786 epsilon subunit interface [polypeptide binding]; other site 283165003787 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 283165003788 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 283165003789 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 283165003790 beta subunit interaction interface [polypeptide binding]; other site 283165003791 Walker A motif; other site 283165003792 ATP binding site [chemical binding]; other site 283165003793 Walker B motif; other site 283165003794 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 283165003795 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 283165003796 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 283165003797 Identified by comparison to Bartonella henselae;priA primosomal replication factor 283165003798 primosome assembly protein PriA; Validated; Region: PRK05580 283165003799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 283165003800 ATP binding site [chemical binding]; other site 283165003801 putative Mg++ binding site [ion binding]; other site 283165003802 helicase superfamily c-terminal domain; Region: HELICc; smart00490 283165003803 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 283165003804 active site 283165003805 intersubunit interactions; other site 283165003806 catalytic residue [active] 283165003807 Lipopolysaccharide-assembly; Region: LptE; cl01125 283165003808 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 283165003809 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 283165003810 HIGH motif; other site 283165003811 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 283165003812 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 283165003813 active site 283165003814 KMSKS motif; other site 283165003815 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 283165003816 tRNA binding surface [nucleotide binding]; other site 283165003817 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 283165003818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 283165003819 catalytic residue [active] 283165003820 acetyl-CoA synthetase; Provisional; Region: PRK00174 283165003821 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 283165003822 active site 283165003823 CoA binding site [chemical binding]; other site 283165003824 acyl-activating enzyme (AAE) consensus motif; other site 283165003825 AMP binding site [chemical binding]; other site 283165003826 acetate binding site [chemical binding]; other site 283165003827 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 283165003828 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 283165003829 Walker A/P-loop; other site 283165003830 ATP binding site [chemical binding]; other site 283165003831 Q-loop/lid; other site 283165003832 ABC transporter signature motif; other site 283165003833 Walker B; other site 283165003834 D-loop; other site 283165003835 H-loop/switch region; other site 283165003836 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 283165003837 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 283165003838 Uncharacterized conserved protein [Function unknown]; Region: COG1434 283165003839 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 283165003840 putative active site [active] 283165003841 Identified by comparison to Bartonella henselae;atpD atp synthase beta chain 283165003842 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 283165003843 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 283165003844 Walker A/P-loop; other site 283165003845 ATP binding site [chemical binding]; other site 283165003846 Q-loop/lid; other site 283165003847 ABC transporter signature motif; other site 283165003848 Walker B; other site 283165003849 D-loop; other site 283165003850 H-loop/switch region; other site 283165003851 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 283165003852 FtsX-like permease family; Region: FtsX; pfam02687 283165003853 macrolide transporter subunit MacA; Provisional; Region: PRK11578 283165003854 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 283165003855 HlyD family secretion protein; Region: HlyD_3; pfam13437 283165003856 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 283165003857 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 283165003858 putative catalytic site [active] 283165003859 putative phosphate binding site [ion binding]; other site 283165003860 active site 283165003861 metal binding site A [ion binding]; metal-binding site 283165003862 DNA binding site [nucleotide binding] 283165003863 putative AP binding site [nucleotide binding]; other site 283165003864 putative metal binding site B [ion binding]; other site 283165003865 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 283165003866 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 283165003867 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 283165003868 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 283165003869 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 283165003870 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 283165003871 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 283165003872 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 283165003873 H-NS histone family; Region: Histone_HNS; pfam00816 283165003874 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 283165003875 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 283165003876 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003877 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003878 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003879 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003880 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003881 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003882 TrbC/VIRB2 family; Region: TrbC; pfam04956 283165003883 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 283165003884 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 283165003885 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 283165003886 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 283165003887 Type IV secretion system proteins; Region: T4SS; pfam07996 283165003888 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 283165003889 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 283165003890 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 283165003891 Type IV secretion system proteins; Region: T4SS; pfam07996 283165003892 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 283165003893 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 283165003894 VirB8 protein; Region: VirB8; pfam04335 283165003895 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 283165003896 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 283165003897 VirB7 interaction site; other site 283165003898 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 283165003899 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 283165003900 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 283165003901 Walker A motif; other site 283165003902 hexamer interface [polypeptide binding]; other site 283165003903 ATP binding site [chemical binding]; other site 283165003904 Walker B motif; other site 283165003905 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 283165003906 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 283165003907 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 283165003908 L-aspartate oxidase; Provisional; Region: PRK06175 283165003909 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 283165003910 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 283165003911 putative SdhC subunit interface [polypeptide binding]; other site 283165003912 putative proximal heme binding site [chemical binding]; other site 283165003913 putative Iron-sulfur protein interface [polypeptide binding]; other site 283165003914 putative proximal quinone binding site; other site 283165003915 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 283165003916 Iron-sulfur protein interface; other site 283165003917 proximal quinone binding site [chemical binding]; other site 283165003918 SdhD (CybS) interface [polypeptide binding]; other site 283165003919 proximal heme binding site [chemical binding]; other site 283165003920 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 283165003921 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 283165003922 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 283165003923 RimM N-terminal domain; Region: RimM; pfam01782 283165003924 PRC-barrel domain; Region: PRC; pfam05239 283165003925 SapC; Region: SapC; pfam07277 283165003926 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 283165003927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 283165003928 active site 283165003929 DNA binding site [nucleotide binding] 283165003930 Int/Topo IB signature motif; other site 283165003931 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 283165003932 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 283165003933 HSP70 interaction site [polypeptide binding]; other site 283165003934 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 283165003935 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 283165003936 AAA domain; Region: AAA_17; pfam13207 283165003937 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 283165003938 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 283165003939 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 283165003940 metal ion-dependent adhesion site (MIDAS); other site 283165003941 Identified by comparison to Bartonella henselae;transmembrane protein 283165003942 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 283165003943 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 283165003944 Identified by comparison to Bartonella henselae;hypothetical protein 283165003945 Identified by comparison to Bartonella henselae;purH 283165003946 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 283165003947 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 283165003948 purine monophosphate binding site [chemical binding]; other site 283165003949 dimer interface [polypeptide binding]; other site 283165003950 putative catalytic residues [active] 283165003951 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 283165003952 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 283165003953 NusB family; Region: NusB; pfam01029 283165003954 putative RNA binding site [nucleotide binding]; other site 283165003955 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 283165003956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165003957 S-adenosylmethionine binding site [chemical binding]; other site 283165003958 heat shock protein HtpX; Provisional; Region: PRK01345 283165003959 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 283165003960 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 283165003961 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 283165003962 chorismate mutase; Provisional; Region: PRK09239 283165003963 signal recognition particle protein; Provisional; Region: PRK10867 283165003964 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 283165003965 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 283165003966 P loop; other site 283165003967 GTP binding site [chemical binding]; other site 283165003968 Signal peptide binding domain; Region: SRP_SPB; pfam02978 283165003969 Identified by comparison to Bartonella henselae;carbonic anhydrase 283165003970 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 283165003971 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 283165003972 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 283165003973 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 283165003974 catalytic triad [active] 283165003975 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 283165003976 HemY protein N-terminus; Region: HemY_N; pfam07219 283165003977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 283165003978 TPR motif; other site 283165003979 binding surface 283165003980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 283165003981 UGMP family protein; Validated; Region: PRK09604 283165003982 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 283165003983 EVE domain; Region: EVE; cl00728 283165003984 Identified by comparison to Bartonella henselae;hypothetical protein 283165003985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 283165003986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 283165003987 active site 283165003988 phosphorylation site [posttranslational modification] 283165003989 intermolecular recognition site; other site 283165003990 dimerization interface [polypeptide binding]; other site 283165003991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 283165003992 DNA binding site [nucleotide binding] 283165003993 Methyltransferase domain; Region: Methyltransf_23; pfam13489 283165003994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 283165003995 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 283165003996 diaminopimelate decarboxylase; Region: lysA; TIGR01048 283165003997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 283165003998 active site 283165003999 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 283165004000 substrate binding site [chemical binding]; other site 283165004001 catalytic residues [active] 283165004002 dimer interface [polypeptide binding]; other site 283165004003 Identified by comparison to Brucella melitensis;hypothetical protein 283165004004 Identified by comparison to Brucella melitensis;argininosuccinate lyase 283165004005 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 283165004006 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 283165004007 catalytic residues [active] 283165004008 Identified by comparison to Bartonella henselae;hypothetical protein 283165004009 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 283165004010 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 283165004011 prephenate dehydrogenase; Validated; Region: PRK08507 283165004012 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 283165004013 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 283165004014 Identified by comparison to Bartonella henselae;abc transporter atp-binding protein 283165004015 Identified by comparison to Bartonella henselae;abc transporter permease 283165004016 Identified by comparison to Bartonella henselae;hypothetical protein 283165004017 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 283165004018 dimer interface [polypeptide binding]; other site 283165004019 substrate binding site [chemical binding]; other site 283165004020 ATP binding site [chemical binding]; other site 283165004021 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 283165004022 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 283165004023 putative acyl-acceptor binding pocket; other site 283165004024 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 283165004025 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 283165004026 Identified by comparison to Bartonella henselae;hypothetical protein 283165004027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 283165004028 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 283165004029 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 283165004030 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 283165004031 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 283165004032 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 283165004033 active site 283165004034 DNA binding site [nucleotide binding] 283165004035 Int/Topo IB signature motif; other site 283165004036 shikimate kinase; Provisional; Region: PRK13946 283165004037 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 283165004038 ADP binding site [chemical binding]; other site 283165004039 magnesium binding site [ion binding]; other site 283165004040 putative shikimate binding site; other site 283165004041 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 283165004042 active site 283165004043 dimer interface [polypeptide binding]; other site 283165004044 metal binding site [ion binding]; metal-binding site 283165004045 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 283165004046 Predicted periplasmic protein [General function prediction only]; Region: COG3895 283165004047 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 283165004048 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 283165004049 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 283165004050 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 283165004051 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 283165004052 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 283165004053 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 283165004054 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 283165004055 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 283165004056 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 283165004057 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 283165004058 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 283165004059 BA14K-like protein; Region: BA14K; pfam07886 283165004060 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 283165004061 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 283165004062 dimer interface [polypeptide binding]; other site 283165004063 active site 283165004064 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 283165004065 catalytic residues [active] 283165004066 substrate binding site [chemical binding]; other site 283165004067 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 283165004068 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 283165004069 NAD(P) binding pocket [chemical binding]; other site 283165004070 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 283165004071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 283165004072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 283165004073 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 283165004074 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 283165004075 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 283165004076 E3 interaction surface; other site 283165004077 lipoyl attachment site [posttranslational modification]; other site 283165004078 e3 binding domain; Region: E3_binding; pfam02817 283165004079 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 283165004080 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 283165004081 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 283165004082 TPP-binding site [chemical binding]; other site 283165004083 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 283165004084 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 283165004085 CoA binding domain; Region: CoA_binding; smart00881 283165004086 CoA-ligase; Region: Ligase_CoA; pfam00549 283165004087 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 283165004088 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 283165004089 CoA-ligase; Region: Ligase_CoA; pfam00549 283165004090 malate dehydrogenase; Reviewed; Region: PRK06223 283165004091 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 283165004092 NAD(P) binding site [chemical binding]; other site 283165004093 dimer interface [polypeptide binding]; other site 283165004094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 283165004095 substrate binding site [chemical binding]; other site 283165004096 Predicted ATPase [General function prediction only]; Region: COG1485 283165004097 Protease inhibitor Inh; Region: Inh; pfam02974 283165004098 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 283165004099 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 283165004100 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 283165004101 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 283165004102 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 283165004103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 283165004104 FeS/SAM binding site; other site 283165004105 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 283165004106 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 283165004107 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 283165004108 P loop; other site 283165004109 GTP binding site [chemical binding]; other site 283165004110 intracellular septation protein A; Reviewed; Region: PRK00259 283165004111 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 283165004112 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 283165004113 ParB-like nuclease domain; Region: ParB; smart00470 283165004114 KorB domain; Region: KorB; pfam08535 283165004115 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 283165004116 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 283165004117 P-loop; other site 283165004118 Magnesium ion binding site [ion binding]; other site 283165004119 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 283165004120 Magnesium ion binding site [ion binding]; other site 283165004121 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 283165004122 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 283165004123 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 283165004124 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 283165004125 L-aspartate oxidase; Provisional; Region: PRK06175 283165004126 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 283165004127 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 283165004128 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 283165004129 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 283165004130 trmE is a tRNA modification GTPase; Region: trmE; cd04164 283165004131 G1 box; other site 283165004132 GTP/Mg2+ binding site [chemical binding]; other site 283165004133 Switch I region; other site 283165004134 G2 box; other site 283165004135 Switch II region; other site 283165004136 G3 box; other site 283165004137 G4 box; other site 283165004138 G5 box; other site 283165004139 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 283165004140 transcription termination factor Rho; Provisional; Region: rho; PRK09376 283165004141 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 283165004142 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 283165004143 RNA binding site [nucleotide binding]; other site 283165004144 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 283165004145 multimer interface [polypeptide binding]; other site 283165004146 Walker A motif; other site 283165004147 ATP binding site [chemical binding]; other site 283165004148 Walker B motif; other site