-- dump date 20140619_000611 -- class Genbank::CDS -- table cds_note -- id note NP_808942.1 SusC homolog NP_808943.1 SusD homolog NP_808958.1 similar to succinoglycan biosynthesis protein NP_808969.1 similar to UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase NP_808973.1 similar to GumB protein NP_808974.1 similar to tyrosine-protein kinase ptk NP_808991.1 radC homolog NP_808997.1 TraQ homolog NP_808998.1 TraO homolog NP_808999.1 TraN homolog NP_809000.1 TraM homolog NP_809001.1 weak TraL homolog NP_809002.1 TraK homolog NP_809003.1 TraJ homolog NP_809004.1 TraI homolog NP_809005.1 TraH homolog NP_809006.1 TraG homolog NP_809007.1 TraF homolog NP_809008.1 TraE homolog NP_809010.1 TraB homolog NP_809011.1 TraA homolog NP_809014.1 similar to mobilization protein BmgA NP_809015.1 similar to mobilization protein C NP_809023.1 similar to rteC, tetracycline resistance element mobilization regulatory protein NP_809031.1 similar to cytochrome c biogenesis protein (ccdA) NP_809035.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; in Pseudomonas this protein is involved in quinolone signal biosynthesis NP_809042.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate NP_809043.1 Converts D-mannonate to D-mannuronate NP_809046.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_809052.1 similar to RpoE NP_809053.1 SusC homolog NP_809054.1 SusD homolog NP_809061.1 similar to hemolysin NP_809062.1 similar to metalloprotease yggG NP_809063.1 similar to ferric aerobactin receptor NP_809068.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_809079.1 similar to thiol-disulfide isomerase NP_809092.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_809097.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_809103.1 SusC homolog NP_809104.1 SusD homolog NP_809105.1 similar to serine/threonine protein kinase NP_809113.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors NP_809114.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer NP_809116.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate NP_809118.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_809119.1 SusC homolog NP_809120.1 weak SusD homolog NP_809125.1 similar to halolysin precursor NP_809129.1 similar to rubrerythrin NP_809135.1 homology to two-component system sensor kinases, but no kinase domain NP_809141.1 homology to protein involved in recombination NP_809145.1 TnpC homolog NP_809147.1 TnpA homolog NP_809151.1 anSME; radical SAM enzyme; oxidizes both cysteine and serine residues to C-alpha-formylglycine in sulfatase enzyme protein substrates NP_809157.1 exonuclease sbcD homolog NP_809163.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides NP_809181.1 SusC homolog NP_809182.1 SusD homolog NP_809185.1 SusC homolog NP_809194.1 HU homolog NP_809197.1 similar to internalin NP_809201.1 weak similarity to myosin heavy chain NP_809220.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate NP_809226.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_809227.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_809229.1 weak similarity to hemin receptor NP_809230.1 SusC homolog NP_809244.1 Couples the complete acetyl-CoA oxidation to aromatic ring reduction by the use of the low-potential electron shuttle ferredoxin NP_809264.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism NP_809265.1 crystal structure of protein from Xanthomonas shows pentameric toroidal structure; physiological function is unknown NP_809266.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source NP_809273.1 similar to arabinan endo-1,5-alpha-L-arabinosidase NP_809275.1 SusC homolog NP_809277.1 SusC homolog NP_809289.1 Bacteroides fragilis UpcY homolog NP_809290.1 Bacteroides fragilis UpaZ homolog NP_809325.1 similar to Na+/sulfate symporter NP_809327.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP NP_809328.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ NP_809332.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_809333.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_809335.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_809336.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_809338.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_809340.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine NP_809342.1 Involved in the incorporation of exogenous aryl acids in the biosynthesis of aromatic amino acids: catalysis of the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. NP_809352.1 SusC homolog NP_809353.1 SusD homolog NP_809363.1 week homology to glucoamylase (alpha-1,4-glucan glucosidase) NP_809364.1 SusD homolog NP_809365.1 SusC homolog NP_809375.1 Bacteroides fragilis UpdY homolog NP_809380.1 similar to flippase NP_809396.1 SusC homolog NP_809397.1 SusD homolog NP_809398.1 similar to pilin gene inverting protein NP_809402.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate NP_809405.1 similar to MotA/TolQ/ExbB proton channel family protein NP_809430.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_809431.1 Catalyzes the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate NP_809437.1 similar to phosphate regulon transcriptional regulatory protein NP_809440.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_809442.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water NP_809446.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_809448.1 similar to NADH-dependent butanol dehydrogenase NP_809454.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate NP_809459.1 similar to FrrB NP_809460.1 catalyzes the interconversion of tetrahydrodipicolinate and L,L-diaminopimelate in lysine biosynthesis NP_809461.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate NP_809464.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP NP_809467.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_809469.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_809473.1 similar to agglutination protein NP_809480.1 homolog to SanA involved in barrier function of the cell envelope NP_809482.1 similar to acetylhydrolase NP_809483.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_809502.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_809503.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_809509.1 Bacteroides fragilis UpcY homolog NP_809510.1 Bacteroides fragilis UpcZ homolog NP_809517.1 coenzyme F420-reducing hydrogenase beta subunit homolog NP_809526.1 homolog to EPS I polysaccharide export outer membrane protein NP_809530.1 involved in the electron transport chain; in Methanosarcina acetivorans this protein is part of a cluster involved in electron transfer during growth on acetate NP_809534.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase NP_809537.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis NP_809539.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_809545.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_809557.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_809562.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center NP_809563.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine NP_809564.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate NP_809565.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate NP_809585.1 similar to acriflavine resistance protein NP_809598.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli NP_809600.2 catalyzes the reduction of hydroxylamine to ammonia and water NP_809609.1 homolog to cation efflux pump NP_809611.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_809617.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis NP_809619.1 homolog to N-acetylmuramoyl-L-alanine amidase NP_809624.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_809630.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_809631.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_809632.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit NP_809648.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate NP_809650.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate NP_809651.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_809654.1 involved in the allosteric regulation of aspartate carbamoyltransferase NP_809655.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_809658.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS NP_809661.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_809666.1 FrrF homolog NP_809667.1 SusC homolog NP_809674.1 similar to exported 24-amino acid repeat protein NP_809679.1 similar to O-linked N-acetylglucosamine transferase NP_809680.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine NP_809706.1 catalyzes the interconversion of D-xylose to D-xylulose NP_809707.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter NP_809719.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) NP_809721.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_809736.2 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism NP_809738.1 catalyzes the formation of D-tagaturonate from D-altronate NP_809746.1 similar to thiol:disulfide interchange protein NP_809778.1 similar to chitobiase NP_809779.1 SusD homolog NP_809780.1 SusC homolog NP_809784.1 similar to diacylglycerol kinase NP_809785.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_809798.1 similar to acriflavine resistance protein E precursor NP_809799.1 similar to acriflavine resistance protein B NP_809801.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile NP_809805.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits NP_809806.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_809808.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_809810.1 molecular chaperone NP_809813.1 similar to tetratricopeptide repeat family protein NP_809828.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_809829.1 required for 70S ribosome assembly NP_809833.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_809842.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_809876.1 ferredoxin-type protein napF homolog NP_809877.1 SusC homolog NP_809878.1 FrrF homolog NP_809922.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_809937.1 SusD homolog NP_809938.1 SusC homolog NP_809941.1 SusD homolog NP_809942.1 SusC homolog NP_809945.1 similar to alpha-1,2-mannosidase NP_809947.1 similar to beta-lactamase induction signal transducer NP_809953.1 SusC homolog NP_809955.1 SusC homolog NP_809959.1 SusC homolog NP_809965.1 FrrF homolog NP_809988.1 similar to two-component system sensor protein NP_809994.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_809996.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_809999.1 similar to oligopeptide transporter NP_810002.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein NP_810011.1 catalyzes the formation of methylglyoxal from glycerone phosphate NP_810012.1 similar to arginase NP_810015.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_810018.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_810019.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate NP_810031.1 SusD homolog NP_810032.1 SusC homolog NP_810035.1 similar to 3-carboxymuconate cyclase NP_810058.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_810060.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine NP_810066.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine NP_810068.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_810069.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. NP_810070.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm NP_810071.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_810072.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_810073.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_810074.1 similar to bleomycin hydrolase NP_810099.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence NP_810106.1 similar to multidrug resistance protein norM NP_810108.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan NP_810119.1 crystal structure of protein from Xanthomonas shows pentameric toroidal structure; physiological function is unknown NP_810120.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor NP_810134.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_810135.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_810147.1 similar to regulatory protein with a cAMP-binding domain NP_810157.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_810162.1 multidrug resistance protein A homolog NP_810184.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_810186.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose NP_810192.1 FrrF homolog NP_810193.1 SusC homolog NP_810199.1 adenylate cyclase homolog NP_810210.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex NP_810211.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex NP_810212.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex NP_810230.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_810231.1 similar to two-component system sensor protein NP_810234.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_810238.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_810239.1 similar to O-linked GlcNAc transferase NP_810246.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_810249.1 similar to translation initiation inhibitor, with an endoribonuclease L-PSP domain NP_810270.1 Bacteroides fragilis UpaZ homolog NP_810271.1 Bacteroides fragilis UpaY homolog NP_810281.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_810284.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine NP_810290.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis NP_810291.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_810293.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_810297.1 similar to general stress protein 26(GS26) of B.subtilis NP_810301.1 similar to chaperonin NP_810316.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_810330.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 NP_810342.1 general stress protein 26 homolog NP_810345.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate NP_810346.1 Converts D-mannonate to D-mannuronate NP_810350.1 similar to glycerate kinase NP_810351.1 similar to fosmidomycin resistance protein NP_810352.1 SusD homolog NP_810353.1 SusC homolog NP_810356.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine NP_810359.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium NP_810367.1 similar to release factor 1 and 2 NP_810389.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate NP_810405.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan NP_810465.1 SusC homolog NP_810475.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_810477.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis NP_810488.1 Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthes NP_810505.1 ferrous iron transport protein B homolog NP_810508.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_810514.1 homolog to signal recognition particle NP_810520.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_810526.1 similar to arginyl-tRNA synthetase NP_810531.1 FrrF homolog NP_810532.1 SusC homolog NP_810544.1 SusC homolog NP_810568.1 Bacteroides fragilis UpaZ homolog NP_810569.1 Bacteroides fragilis UpcY homolog NP_810571.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity NP_810572.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate NP_810573.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_810577.2 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity NP_810582.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_810585.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_810589.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell NP_810594.1 similar to carbonic anhydrase NP_810595.1 SusD homolog NP_810596.1 SusC homolog NP_810604.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate NP_810605.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_810626.1 similar to acylneuraminate cytidylyltransferase, with haloacid dehalogenase-like hydrolase domain NP_810628.1 homolog of spore coat polysaccharide biosynthesis protein NP_810630.1 homolog of lipopolysaccharide biosynthesis protein involved in export NP_810637.1 Bacteroides fragilis UpaZ homolog NP_810638.1 Bacteroides fragilis UpcY homolog NP_810646.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_810675.1 SusD homolog NP_810676.1 SusC homolog NP_810687.1 SusC homolog NP_810696.1 similar to Na+/H+-exchange protein NP_810704.1 major outer membrane protein OmpA homolog NP_810712.1 vitamin B12 receptor precursor homolog NP_810716.1 FrrB homolog NP_810725.1 chaperone DnAJ homolog NP_810742.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_810743.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_810747.1 similar to ferredoxin NP_810748.1 catalyzes the formation of biotin from dethiobiotin and sulfur NP_810749.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; in Thermotoga this enzyme has an extra C-terminal domain NP_810753.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_810756.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_810770.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis NP_810773.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_810774.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis NP_810778.1 similar to long tail fiber protein p37 NP_810787.1 SusD homolog NP_810788.1 SusC homolog NP_810789.1 FrrF homolog NP_810794.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation NP_810809.1 cell surface antigen BspA homolog NP_810810.1 LemA homolog NP_810826.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate NP_810831.1 can hydrolyze p-nitrophenyl sulfate; contains a specific cysteine that is converted into C{alpha]-formylglycine upon activation with the anaerobic sulfatase-maturase NP_810852.1 similar to ferrienterobactin receptor precursor NP_810857.1 TnpA homolog NP_810858.1 TraA homolog NP_810866.1 similar to vitamin B receptor NP_810882.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate NP_810883.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NAD and NADP; forms a homohexamer NP_810886.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADH; forms a homohexamer NP_810891.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_810911.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_810915.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_810917.1 Essential for efficient processing of 16S rRNA NP_810918.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_810922.1 Essential for recycling GMP and indirectly, cGMP NP_810924.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria NP_810928.1 similar to menaquinone biosynthesis protein MenA NP_810932.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate NP_810941.1 similar to replication protein NP_810945.1 SusC homolog NP_810960.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_810962.1 similar to AsnC NP_810969.1 similar to DNase NP_810973.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_810974.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway NP_810975.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_810983.2 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_810985.1 Catalyzes the conversion of citrate to isocitrate NP_810991.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_810997.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_811003.1 MDM; functions in conversion of succinate to propionate NP_811009.1 FucR homolog NP_811017.1 weak similarity to mannose-6-phosphate isomerase NP_811020.1 SusC homolog NP_811035.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_811037.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_811041.1 functions in salvage pathway converting L-fucose to GDP-L-fucose; contributes to fucosylated cell surface in Bacteriodes fragilis NP_811042.1 catalyzes the formation of asparagine from aspartate and ammonia NP_811043.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_811053.1 similar to sodium-dependent transporter NP_811056.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_811063.1 catalyzes the formation of methylglyoxal from glycerone phosphate NP_811069.1 sugar phosphate isomerase/epimerase homolog NP_811074.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_811075.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_811076.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_811080.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_811084.1 FrrF homolog NP_811085.1 SusC homolog NP_811108.1 SusD homolog NP_811109.1 SusC homolog NP_811110.1 FrrF homolog NP_811114.1 SusD homolog NP_811115.1 SusC homolog NP_811144.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine NP_811147.1 cytosine/adenosine deaminase homolog NP_811154.1 similar to Na+-driven multidrug efflux pump NP_811155.1 Catalyzes the phosphorylation of UMP to UDP NP_811160.1 ryanodine receptor homolog NP_811162.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_811163.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity NP_811165.1 similar to acriflavin resistance protein NP_811181.1 SusC homolog NP_811182.1 SusD homolog NP_811186.1 similar to tetrapyrrole methylase family protein NP_811188.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_811200.1 TraQ homolog NP_811201.1 TraO homolog NP_811202.1 TraN homolog NP_811203.1 TraM homolog NP_811205.1 TraK homolog NP_811206.1 TraJ homolog NP_811207.1 TraI homolog NP_811209.1 TraG homolog, fragment NP_811211.1 TraG homolog, fragment NP_811212.1 TraF homolog NP_811213.1 TraE homolog NP_811214.1 TraD homolog NP_811215.1 TraB homolog NP_811216.1 TraA homolog NP_811218.1 similar to mobilization protein BmgA NP_811219.1 similar to mobilization protein C NP_811224.1 similar to 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase NP_811250.1 TraH homolog NP_811275.1 SusC homolog NP_811276.1 SusD homolog NP_811277.1 SusC homolog NP_811278.1 SusD homolog NP_811279.1 similar to cAMP-binding regulatory protein NP_811284.1 similar to intracellular protease/amidase NP_811290.1 similar to Na+-driven multidrug efflux pump NP_811306.1 SusC homolog NP_811314.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_811315.1 catalyzes the interconversion of 3-phosphoglycerate and 2-phosphoglycerate; this enzyme does not require the cofactor 2,3-bisphosphoglycerate as a phosphate donor; BPG-independent PGAM; aPGAM NP_811316.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways NP_811319.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_811326.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis NP_811335.1 FrrB homolog NP_811336.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex NP_811338.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions NP_811364.1 homology to pyrogenic exotoxin B NP_811373.1 SusD homolog NP_811374.1 SusC homolog NP_811375.1 FrrF homolog NP_811402.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_811412.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion NP_811415.1 similar to pre-collagen NP_811432.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor NP_811444.1 SusC homolog NP_811445.1 SusD homolog NP_811462.1 similar to muramoyltetrapeptide carboxypeptidase NP_811465.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate NP_811473.1 SusC homolog NP_811474.1 FrrF homolog NP_811484.1 catalyzes the formation of glutamate from glutamine NP_811485.1 similar to potassium channel subunit NP_811506.1 TraQ homolog NP_811507.1 TraO homolog NP_811508.1 TraN homolog NP_811509.1 TraM homolog NP_811511.1 TraK homolog NP_811512.1 TraJ homolog NP_811513.1 TraI homolog NP_811514.1 TraH homolog NP_811516.1 TraG homolog NP_811517.1 TraF homolog NP_811522.1 TraA homolog NP_811526.1 similar to mobilization protein BmgA NP_811527.1 similar to mobilization protein C NP_811536.1 similar to alpha-1,6-mannanase NP_811538.1 weak SusD homolog NP_811539.1 SusC homolog NP_811604.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway NP_811606.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism NP_811612.1 is a component of the macrolide binding site in the peptidyl transferase center NP_811613.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_811614.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_811615.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_811616.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_811617.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_811619.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_811620.1 late assembly protein NP_811621.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_811622.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_811623.1 binds 5S rRNA along with protein L5 and L25 NP_811624.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_811625.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_811626.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_811627.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_811628.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_811629.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_811630.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_811631.1 one of the stabilizing components for the large ribosomal subunit NP_811632.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_811633.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_811634.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_811635.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_811636.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_811637.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_811638.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_811639.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_811640.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_811641.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_811642.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_811643.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_811645.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_811646.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_811647.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_811648.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_811649.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_811650.1 binds directly to 23S ribosomal RNA NP_811652.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_811657.1 similar to cytochrome c biogenesis protein NP_811660.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_811667.1 catalyzes the formation of fumarate from aspartate NP_811668.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB NP_811669.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis NP_811694.1 activates fatty acids by binding to coenzyme A NP_811698.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_811702.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP NP_811703.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_811705.1 similar to MFS transporter NP_811706.1 multidrug resistance protein A homolog NP_811709.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine NP_811717.1 SusC homolog NP_811729.1 similar to TonB-dependent receptor NP_811730.1 SusC homolog NP_811732.1 SusC homolog NP_811733.1 SusD homolog NP_811734.1 similar to cell surface protein NP_811741.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_811747.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_811749.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin NP_811750.1 similar to ABC transporter permease component NP_811753.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_811754.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis NP_811757.1 weak similarity to AhpC/TSA family protein NP_811759.1 similar to GGDEF family protein NP_811770.1 weak SusD homolog NP_811771.1 SusC homolog NP_811773.1 major outer membrane protein OmpA homolog NP_811776.1 lipopolysaccharide core biosynthesis glycosyltransferase homolog NP_811781.1 similar to succinoglycan biosynthesis protein exoH, succinyltransferase NP_811785.1 similar to general stress protein A NP_811798.1 Bacteroides fragilis UpcY homolog NP_811806.1 SusC homolog NP_811817.1 SusC homolog NP_811827.1 similar to rhizobiocin/RTX toxin NP_811831.1 SusD homolog NP_811832.1 SusC homolog NP_811845.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_811852.1 similar to acriflavine resistance protein A precursor NP_811861.1 similar to alpha-1,6-mannanase NP_811863.1 SusD homolog NP_811864.1 SusC homolog NP_811865.1 transports L-rhamnose and L-lyxose into the cell NP_811879.1 SusD homolog NP_811880.1 SusC homolog NP_811887.1 Modulates the activities of several enzymes which are inactive in their acetylated form NP_811923.1 FrrF homolog NP_811924.1 SusC homolog NP_811936.1 SusC homolog NP_811937.1 SusD homolog NP_811939.1 similar to secreted protein containing cell-adhesion domains NP_811945.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_811946.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_811950.1 FrrF homolog NP_811958.1 SusC homolog NP_811964.1 similar to exoenzyme S synthesis regulatory protein ExsA NP_811966.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_811967.1 catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone NP_811987.1 homology to 3-beta hydroxysteroid dehydrogenase/isomerases NP_812001.1 SusD homolog NP_812002.1 SusC homolog NP_812014.1 SusD homolog NP_812015.1 SusC homolog NP_812025.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers NP_812028.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_812030.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_812033.1 This protein performs the mismatch recognition step during the DNA repair process NP_812036.1 similar to human sialic acid-specific acetylesterase II NP_812038.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_812040.1 hydrolyzes non-standard nucleotides such as xanthine and inosine NP_812066.1 similar to two-component system sensor protein NP_812068.1 SusC homolog NP_812069.1 SusD homolog NP_812076.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate NP_812086.1 SusC homolog NP_812087.1 SusD homolog NP_812107.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_812124.1 bacitracin resistance protein BacA (undecaprenol kinase) homolog NP_812126.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_812131.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_812139.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_812143.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate NP_812144.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate NP_812151.1 SusC homolog NP_812152.1 SusC homolog NP_812165.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_812177.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_812178.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_812179.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_812180.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_812182.1 FrrF homolog NP_812183.1 SusC homolog NP_812190.1 FrrF homolog NP_812191.1 SusC homolog NP_812196.1 similar to spore maturation protein NP_812197.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_812209.1 SusC homolog NP_812218.1 similar to sugar isomerase with conserved SIS domain NP_812222.1 SusC homolog NP_812223.1 SusD homolog NP_812243.1 SusD homolog NP_812244.1 SusC homolog NP_812248.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis NP_812255.1 similar to phenylacetic acid degradation protein NP_812258.1 SusC homolog NP_812263.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_812266.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_812267.1 homology to auxin-regulated protein GH3 NP_812268.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_812271.1 carries the fatty acid chain in fatty acid biosynthesis NP_812273.1 Required for the de novo synthesis of pyroxidine via the pdxA branch; catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate NP_812305.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_812306.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis NP_812314.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_812315.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_812316.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_812318.1 with SufCD activates cysteine desulfurase SufS NP_812323.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient NP_812324.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_812331.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_812337.1 similar to EXQQ family membrane proteins involved in exopolysaccharide production NP_812342.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_812356.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_812359.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_812360.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_812363.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_812364.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_812368.1 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_812373.1 catalyzes the formation of dUMP from dUTP NP_812376.1 similar to zinc metalloendopeptidase NP_812386.1 SusD homolog NP_812387.1 SusC homolog NP_812395.1 SusC homolog NP_812405.1 SusC homolog NP_812406.1 SusC homolog NP_812407.1 SusD homolog NP_812413.1 similar to alpha-1,6-mannanase NP_812417.1 SusC homolog NP_812430.1 FrrF homolog NP_812431.1 SusC homolog NP_812432.1 SusD homolog NP_812474.1 similar to endonuclease NP_812480.1 SusD homolog NP_812481.1 SusC homolog NP_812491.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_812498.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate NP_812511.1 similar to glucokinase NP_812514.1 SusD homolog NP_812515.1 SusC homolog NP_812517.1 similar to xylose permease NP_812522.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_812544.1 SusC homolog NP_812559.1 TldD homolog NP_812560.1 PmbA homolog NP_812561.1 LemA homolog, function unknown NP_812581.1 SusC homolog NP_812582.1 SusD homolog NP_812591.1 SusC homolog NP_812601.1 similar to serotonin transporter NP_812604.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_812606.1 DNA repair protein radC homolog NP_812620.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_812621.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_812622.1 similar to eukaryotic-type serine/threonine kinase NP_812624.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_812629.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway NP_812630.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis NP_812631.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate NP_812637.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_812640.1 HemK protein homolog NP_812642.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_812644.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_812660.1 FrrF homolog NP_812661.1 SusC homolog NP_812662.1 outer membrane protein Omp117 homolog NP_812670.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_812675.1 catalyzes the formation of L-rhamnulose from L-rhamnose NP_812676.1 transports L-rhamnose and L-lyxose into the cell NP_812699.1 SusC homolog NP_812703.1 similar to alpha-1,6-mannanase NP_812721.1 endothelin-converting enzyme homolog NP_812722.1 endothelin-converting enzyme homolog NP_812723.1 involved in de novo purine biosynthesis NP_812724.1 functions in MreBCD complex in some organisms NP_812725.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_812740.1 similar to long-tail fiber protein NP_812744.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_812745.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_812746.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_812747.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_812749.1 similar to ABC transporter permease component NP_812753.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_812754.1 binds and unfolds substrates as part of the ClpXP protease NP_812765.1 SusC homolog NP_812772.1 similar to isoflavone reductase NP_812775.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_812782.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_812784.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_812786.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_812787.1 forms a direct contact with the tRNA during translation NP_812788.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_812789.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_812793.1 modulates transcription in response to the NADH/NAD(+) redox state NP_812795.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate NP_812799.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_812801.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_812803.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_812805.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_812822.1 Catalyzes the reversible oxidation of malate to oxaloacetate NP_812828.1 catalyzes the phosphorylation of NAD to NADP NP_812829.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) NP_812830.1 biopolymer transport protein exbB homolog NP_812834.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_812835.1 catalyzes branch migration in Holliday junction intermediates NP_812836.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_812840.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_812842.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer NP_812848.1 similar to UDP-N-acetylglucosamine--peptide N-acetylglucosaminidase NP_812856.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_812863.1 SusC homolog NP_812869.1 SusC homolog NP_812894.1 SusC homolog NP_812903.1 FrrF homolog NP_812906.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_812914.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate NP_812949.1 SusD homolog NP_812950.1 SusC homolog NP_812954.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_812960.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins NP_812977.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen NP_812992.1 SusC homolog NP_812996.1 weak SusD homolog NP_812999.1 SusC homolog NP_813000.1 SusD homolog NP_813001.1 SusC homolog NP_813007.1 similar to lipase/acylhydrolase with GDSL-like motif domain NP_813009.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain NP_813010.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_813013.1 Sec-independent protein translocase protein TatE homolog NP_813014.1 Sec-independent protein translocase protein TatC homolog NP_813017.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate NP_813024.1 SusD homolog NP_813025.1 SusC homolog NP_813032.1 SusC homolog NP_813033.1 SusD homolog NP_813036.1 similar to Fe-S oxidoreductase NP_813038.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate NP_813045.1 SusD homolog NP_813046.1 SusC homolog NP_813053.1 similar to AraC-type regulator NP_813075.1 SusC homolog NP_813076.1 SusD homolog NP_813079.1 SusC homolog NP_813103.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_813110.1 similar to beta-lactamase regulatory protein 1 NP_813111.1 similar to beta-lactamase regulatory protein 1 NP_813112.1 similar to beta-lactamase regulatory protein 1 NP_813114.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_813116.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis NP_813117.1 catalyzes the zinc dependent deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis and catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP in fatty acid biosynthesis NP_813118.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis NP_813121.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_813123.1 LemA homolog, function unknown NP_813127.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_813128.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_813133.1 similar to cell filamentation protein Fic-related protein NP_813148.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_813157.1 SusD homolog NP_813158.1 SusC homolog NP_813159.1 FrrF homolog NP_813164.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_813175.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock NP_813176.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_813178.1 SusC homolog NP_813179.1 SusD homolog NP_813200.1 chromosomal hemolysin secretion protein D homolog NP_813208.1 SusD homolog NP_813209.1 SusC homolog NP_813213.1 similar to rhomboid family protein NP_813219.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine NP_813220.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) NP_813223.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_813224.1 involved in the peptidyltransferase reaction during translation NP_813232.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis NP_813234.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_813239.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_813242.1 similar to S-adenosylmethionine-dependent methyltransferase NP_813256.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_813257.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions NP_813261.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era NP_813264.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_813267.1 FrrF homolog NP_813268.1 SusC homolog NP_813273.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_813277.2 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP NP_813281.1 hemolysin homolog, with a CBS domain NP_813283.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_813286.1 similar to nitrogen assimilation regulatory protein NP_813298.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_813299.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_813310.1 similar to 3-carboxymuconate cyclase NP_813314.1 FrrF homolog NP_813315.1 SusC homolog NP_813328.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP NP_813337.1 similar to TolB protein precursor NP_813369.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal NP_813371.1 SusC homolog NP_813381.1 outer membrane protein Omp117 homolog NP_813385.1 similar to L-lysine 2,3-aminomutase NP_813392.1 major outer membrane protein OmpA homolog NP_813394.1 similar to DNA polymerase-related protein NP_813395.1 similar to MgtC family protein NP_813414.1 similar to Nodulation protein N NP_813439.1 similar to phosphohydrolase NP_813450.1 similar to DNA-damage-inducible protein D NP_813459.1 TnpC homolog NP_813461.1 TnpA homolog NP_813462.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_813483.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_813494.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_813495.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein NP_813498.1 similar to a heat shock protein NP_813499.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_813500.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_813502.1 nitrogen utilization substance protein B homolog NP_813503.1 similar to preprotein translocase subunit, YajC family NP_813516.1 similar to cell wall-associated protein precursor NP_813521.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_813522.1 homolog to bacterioferritin co-migratory protein NP_813526.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_813535.1 in Bacteroides fragilis this site-specific serine recombinase globally regulates a number of loci involved in capsular polysaccharide production NP_813543.1 similar to galactose oxidase precursor NP_813544.1 SusD homolog NP_813545.1 SusC homolog NP_813546.1 FrrF homolog NP_813549.1 similar to phosphate transport regulator NP_813555.1 FrrF homolog NP_813556.1 SusC homolog NP_813562.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues NP_813563.1 similar to oligo alginate lyase NP_813570.1 SusD homolog NP_813571.1 SusC homolog NP_813575.2 catalyzes the formation of L-tryptophan from indole and L-serine NP_813581.1 SusD homolog NP_813582.1 SusC homolog NP_813599.1 similar to mechano-sensitive ion channel NP_813601.1 converts 1,4-alpha-D-glucans to maltodextrin NP_813613.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_813617.1 FrrF homolog NP_813618.1 SusC homolog NP_813620.1 similar to endo-beta-N-acetylglucosaminidase NP_813629.1 aquaporin homolog NP_813634.1 FrrF homolog NP_813635.1 SusC homolog NP_813636.1 SusD homolog NP_813669.1 similar to mobilization protein C NP_813670.1 similar to mobilization protein BmgA NP_813672.1 TraA homolog, fragment NP_813673.1 TraA homolog, fragment NP_813674.1 TraC homolog NP_813678.1 TraE homolog NP_813679.1 TraF homolog NP_813680.1 TraG homolog, fragment NP_813681.1 TraG homolog, fragment NP_813683.1 TraI homolog, fragment NP_813684.1 TraI homolog, fragment NP_813685.1 TraJ homolog NP_813686.1 TraK homolog, fragment NP_813687.1 TraK homolog, fragment NP_813689.1 TraM homolog, fragment NP_813690.1 TraM homolog, fragment NP_813691.1 TraN homolog NP_818980.1 similar to immunoreactive 53 kD antigen PG123 in Porphyromonas gingivalis NP_818991.1 TraC