-- dump date 20140618_235654 -- class Genbank::misc_feature -- table misc_feature_note -- id note 281309000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 281309000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 281309000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309000004 Walker A motif; other site 281309000005 ATP binding site [chemical binding]; other site 281309000006 Walker B motif; other site 281309000007 arginine finger; other site 281309000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 281309000009 DnaA box-binding interface [nucleotide binding]; other site 281309000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 281309000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 281309000012 putative DNA binding surface [nucleotide binding]; other site 281309000013 dimer interface [polypeptide binding]; other site 281309000014 beta-clamp/clamp loader binding surface; other site 281309000015 beta-clamp/translesion DNA polymerase binding surface; other site 281309000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 281309000017 recombination protein F; Reviewed; Region: recF; PRK00064 281309000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 281309000019 Walker A/P-loop; other site 281309000020 ATP binding site [chemical binding]; other site 281309000021 Q-loop/lid; other site 281309000022 ABC transporter signature motif; other site 281309000023 Walker B; other site 281309000024 D-loop; other site 281309000025 H-loop/switch region; other site 281309000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 281309000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309000028 ATP binding site [chemical binding]; other site 281309000029 Mg2+ binding site [ion binding]; other site 281309000030 G-X-G motif; other site 281309000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 281309000032 anchoring element; other site 281309000033 dimer interface [polypeptide binding]; other site 281309000034 ATP binding site [chemical binding]; other site 281309000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 281309000036 active site 281309000037 putative metal-binding site [ion binding]; other site 281309000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 281309000039 DNA gyrase subunit A; Validated; Region: PRK05560 281309000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 281309000041 CAP-like domain; other site 281309000042 active site 281309000043 primary dimer interface [polypeptide binding]; other site 281309000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309000050 YaaC-like Protein; Region: YaaC; pfam14175 281309000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 281309000052 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 281309000053 active site 281309000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 281309000055 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309000056 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 281309000057 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 281309000058 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 281309000059 active site 281309000060 multimer interface [polypeptide binding]; other site 281309000061 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 281309000062 predicted active site [active] 281309000063 catalytic triad [active] 281309000064 seryl-tRNA synthetase; Provisional; Region: PRK05431 281309000065 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 281309000066 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 281309000067 dimer interface [polypeptide binding]; other site 281309000068 active site 281309000069 motif 1; other site 281309000070 motif 2; other site 281309000071 motif 3; other site 281309000072 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 281309000073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 281309000074 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 281309000075 DNA binding residues [nucleotide binding] 281309000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 281309000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 281309000078 Substrate-binding site [chemical binding]; other site 281309000079 Substrate specificity [chemical binding]; other site 281309000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 281309000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 281309000082 Substrate-binding site [chemical binding]; other site 281309000083 Substrate specificity [chemical binding]; other site 281309000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 281309000085 catalytic triad [active] 281309000086 conserved cis-peptide bond; other site 281309000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 281309000088 nucleoside/Zn binding site; other site 281309000089 dimer interface [polypeptide binding]; other site 281309000090 catalytic motif [active] 281309000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 281309000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309000093 Walker A motif; other site 281309000094 ATP binding site [chemical binding]; other site 281309000095 Walker B motif; other site 281309000096 arginine finger; other site 281309000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 281309000098 hypothetical protein; Validated; Region: PRK00153 281309000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 281309000100 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 281309000101 RecR protein; Region: RecR; pfam02132 281309000102 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 281309000103 putative active site [active] 281309000104 putative metal-binding site [ion binding]; other site 281309000105 tetramer interface [polypeptide binding]; other site 281309000106 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 281309000107 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 281309000108 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 281309000109 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 281309000110 homodimer interface [polypeptide binding]; other site 281309000111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309000112 catalytic residue [active] 281309000113 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 281309000114 thymidylate kinase; Validated; Region: tmk; PRK00698 281309000115 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 281309000116 TMP-binding site; other site 281309000117 ATP-binding site [chemical binding]; other site 281309000118 DNA polymerase III subunit delta'; Validated; Region: PRK08058 281309000119 DNA polymerase III subunit delta'; Validated; Region: PRK08485 281309000120 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 281309000121 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 281309000122 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 281309000123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309000124 S-adenosylmethionine binding site [chemical binding]; other site 281309000125 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 281309000126 GIY-YIG motif/motif A; other site 281309000127 putative active site [active] 281309000128 putative metal binding site [ion binding]; other site 281309000129 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 281309000130 putative SAM binding site [chemical binding]; other site 281309000131 putative homodimer interface [polypeptide binding]; other site 281309000132 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 281309000133 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 281309000134 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 281309000135 active site 281309000136 HIGH motif; other site 281309000137 KMSKS motif; other site 281309000138 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 281309000139 tRNA binding surface [nucleotide binding]; other site 281309000140 anticodon binding site; other site 281309000141 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 281309000142 dimer interface [polypeptide binding]; other site 281309000143 putative tRNA-binding site [nucleotide binding]; other site 281309000144 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 281309000145 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 281309000146 active site 281309000147 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 281309000148 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 281309000149 putative active site [active] 281309000150 putative metal binding site [ion binding]; other site 281309000151 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 281309000152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309000153 S-adenosylmethionine binding site [chemical binding]; other site 281309000154 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 281309000155 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 281309000156 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 281309000157 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 281309000158 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 281309000159 pur operon repressor; Provisional; Region: PRK09213 281309000160 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 281309000161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309000162 active site 281309000163 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 281309000164 homotrimer interaction site [polypeptide binding]; other site 281309000165 putative active site [active] 281309000166 regulatory protein SpoVG; Reviewed; Region: PRK13259 281309000167 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 281309000168 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 281309000169 Substrate binding site; other site 281309000170 Mg++ binding site; other site 281309000171 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 281309000172 active site 281309000173 substrate binding site [chemical binding]; other site 281309000174 CoA binding site [chemical binding]; other site 281309000175 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 281309000176 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 281309000177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309000178 active site 281309000179 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 281309000180 putative active site [active] 281309000181 catalytic residue [active] 281309000182 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 281309000183 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 281309000184 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 281309000185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309000186 ATP binding site [chemical binding]; other site 281309000187 putative Mg++ binding site [ion binding]; other site 281309000188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309000189 nucleotide binding region [chemical binding]; other site 281309000190 ATP-binding site [chemical binding]; other site 281309000191 TRCF domain; Region: TRCF; pfam03461 281309000192 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 281309000193 stage V sporulation protein T; Region: spore_V_T; TIGR02851 281309000194 stage V sporulation protein B; Region: spore_V_B; TIGR02900 281309000195 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 281309000196 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 281309000197 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 281309000198 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 281309000199 putative SAM binding site [chemical binding]; other site 281309000200 putative homodimer interface [polypeptide binding]; other site 281309000201 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 281309000202 homodimer interface [polypeptide binding]; other site 281309000203 metal binding site [ion binding]; metal-binding site 281309000204 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 281309000205 homodimer interface [polypeptide binding]; other site 281309000206 active site 281309000207 putative chemical substrate binding site [chemical binding]; other site 281309000208 metal binding site [ion binding]; metal-binding site 281309000209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309000210 RNA binding surface [nucleotide binding]; other site 281309000211 sporulation protein YabP; Region: spore_yabP; TIGR02892 281309000212 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 281309000213 Septum formation initiator; Region: DivIC; pfam04977 281309000214 hypothetical protein; Provisional; Region: PRK08582 281309000215 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 281309000216 RNA binding site [nucleotide binding]; other site 281309000217 stage II sporulation protein E; Region: spore_II_E; TIGR02865 281309000218 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 281309000219 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 281309000220 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 281309000221 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 281309000222 Ligand Binding Site [chemical binding]; other site 281309000223 TilS substrate binding domain; Region: TilS; pfam09179 281309000224 TilS substrate C-terminal domain; Region: TilS_C; smart00977 281309000225 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309000226 active site 281309000227 FtsH Extracellular; Region: FtsH_ext; pfam06480 281309000228 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 281309000229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309000230 Walker A motif; other site 281309000231 ATP binding site [chemical binding]; other site 281309000232 Walker B motif; other site 281309000233 arginine finger; other site 281309000234 Peptidase family M41; Region: Peptidase_M41; pfam01434 281309000235 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309000236 nucleotide binding site [chemical binding]; other site 281309000237 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 281309000238 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 281309000239 dimerization interface [polypeptide binding]; other site 281309000240 domain crossover interface; other site 281309000241 redox-dependent activation switch; other site 281309000242 cysteine synthase; Region: PLN02565 281309000243 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 281309000244 dimer interface [polypeptide binding]; other site 281309000245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309000246 catalytic residue [active] 281309000247 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 281309000248 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 281309000249 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 281309000250 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 281309000251 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 281309000252 glutamine binding [chemical binding]; other site 281309000253 catalytic triad [active] 281309000254 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 281309000255 homodimer interface [polypeptide binding]; other site 281309000256 substrate-cofactor binding pocket; other site 281309000257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309000258 catalytic residue [active] 281309000259 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 281309000260 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 281309000261 substrate binding pocket [chemical binding]; other site 281309000262 dimer interface [polypeptide binding]; other site 281309000263 inhibitor binding site; inhibition site 281309000264 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 281309000265 homooctamer interface [polypeptide binding]; other site 281309000266 active site 281309000267 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 281309000268 catalytic center binding site [active] 281309000269 ATP binding site [chemical binding]; other site 281309000270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309000271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309000272 non-specific DNA binding site [nucleotide binding]; other site 281309000273 salt bridge; other site 281309000274 sequence-specific DNA binding site [nucleotide binding]; other site 281309000275 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 281309000276 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 281309000277 FMN binding site [chemical binding]; other site 281309000278 active site 281309000279 catalytic residues [active] 281309000280 substrate binding site [chemical binding]; other site 281309000281 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 281309000282 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 281309000283 dimer interface [polypeptide binding]; other site 281309000284 putative anticodon binding site; other site 281309000285 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 281309000286 motif 1; other site 281309000287 active site 281309000288 motif 2; other site 281309000289 motif 3; other site 281309000290 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 281309000291 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 281309000292 UvrB/uvrC motif; Region: UVR; pfam02151 281309000293 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 281309000294 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 281309000295 ADP binding site [chemical binding]; other site 281309000296 phosphagen binding site; other site 281309000297 substrate specificity loop; other site 281309000298 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 281309000299 Clp amino terminal domain; Region: Clp_N; pfam02861 281309000300 Clp amino terminal domain; Region: Clp_N; pfam02861 281309000301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309000302 Walker A motif; other site 281309000303 ATP binding site [chemical binding]; other site 281309000304 Walker B motif; other site 281309000305 arginine finger; other site 281309000306 UvrB/uvrC motif; Region: UVR; pfam02151 281309000307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309000308 Walker A motif; other site 281309000309 ATP binding site [chemical binding]; other site 281309000310 Walker B motif; other site 281309000311 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 281309000312 DNA repair protein RadA; Provisional; Region: PRK11823 281309000313 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 281309000314 Walker A motif/ATP binding site; other site 281309000315 ATP binding site [chemical binding]; other site 281309000316 Walker B motif; other site 281309000317 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 281309000318 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 281309000319 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 281309000320 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 281309000321 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 281309000322 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 281309000323 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 281309000324 putative active site [active] 281309000325 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 281309000326 substrate binding site; other site 281309000327 dimer interface; other site 281309000328 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 281309000329 homotrimer interaction site [polypeptide binding]; other site 281309000330 zinc binding site [ion binding]; other site 281309000331 CDP-binding sites; other site 281309000332 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 281309000333 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 281309000334 active site 281309000335 HIGH motif; other site 281309000336 KMSKS motif; other site 281309000337 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 281309000338 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 281309000339 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 281309000340 trimer interface [polypeptide binding]; other site 281309000341 active site 281309000342 substrate binding site [chemical binding]; other site 281309000343 CoA binding site [chemical binding]; other site 281309000344 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 281309000345 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 281309000346 active site 281309000347 HIGH motif; other site 281309000348 KMSKS motif; other site 281309000349 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 281309000350 tRNA binding surface [nucleotide binding]; other site 281309000351 anticodon binding site; other site 281309000352 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 281309000353 active site 281309000354 metal binding site [ion binding]; metal-binding site 281309000355 dimerization interface [polypeptide binding]; other site 281309000356 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 281309000357 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 281309000358 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 281309000359 YacP-like NYN domain; Region: NYN_YacP; pfam05991 281309000360 RNA polymerase factor sigma-70; Validated; Region: PRK08295 281309000361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309000362 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281309000363 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 281309000364 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 281309000365 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 281309000366 putative homodimer interface [polypeptide binding]; other site 281309000367 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 281309000368 heterodimer interface [polypeptide binding]; other site 281309000369 homodimer interface [polypeptide binding]; other site 281309000370 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 281309000371 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 281309000372 23S rRNA interface [nucleotide binding]; other site 281309000373 L7/L12 interface [polypeptide binding]; other site 281309000374 putative thiostrepton binding site; other site 281309000375 L25 interface [polypeptide binding]; other site 281309000376 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 281309000377 mRNA/rRNA interface [nucleotide binding]; other site 281309000378 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 281309000379 23S rRNA interface [nucleotide binding]; other site 281309000380 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 281309000381 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 281309000382 core dimer interface [polypeptide binding]; other site 281309000383 peripheral dimer interface [polypeptide binding]; other site 281309000384 L10 interface [polypeptide binding]; other site 281309000385 L11 interface [polypeptide binding]; other site 281309000386 putative EF-Tu interaction site [polypeptide binding]; other site 281309000387 putative EF-G interaction site [polypeptide binding]; other site 281309000388 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 281309000389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309000390 S-adenosylmethionine binding site [chemical binding]; other site 281309000391 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 281309000392 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 281309000393 RPB12 interaction site [polypeptide binding]; other site 281309000394 RPB1 interaction site [polypeptide binding]; other site 281309000395 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 281309000396 RPB10 interaction site [polypeptide binding]; other site 281309000397 RPB11 interaction site [polypeptide binding]; other site 281309000398 RPB3 interaction site [polypeptide binding]; other site 281309000399 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 281309000400 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 281309000401 beta and beta' interface [polypeptide binding]; other site 281309000402 beta' and sigma factor interface [polypeptide binding]; other site 281309000403 Zn-binding [ion binding]; other site 281309000404 active site region [active] 281309000405 catalytic site [active] 281309000406 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 281309000407 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 281309000408 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 281309000409 G-loop; other site 281309000410 DNA binding site [nucleotide binding] 281309000411 hypothetical protein; Provisional; Region: PRK06683 281309000412 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 281309000413 S17 interaction site [polypeptide binding]; other site 281309000414 S8 interaction site; other site 281309000415 16S rRNA interaction site [nucleotide binding]; other site 281309000416 streptomycin interaction site [chemical binding]; other site 281309000417 23S rRNA interaction site [nucleotide binding]; other site 281309000418 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 281309000419 30S ribosomal protein S7; Validated; Region: PRK05302 281309000420 elongation factor G; Reviewed; Region: PRK00007 281309000421 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 281309000422 G1 box; other site 281309000423 putative GEF interaction site [polypeptide binding]; other site 281309000424 GTP/Mg2+ binding site [chemical binding]; other site 281309000425 Switch I region; other site 281309000426 G2 box; other site 281309000427 G3 box; other site 281309000428 Switch II region; other site 281309000429 G4 box; other site 281309000430 G5 box; other site 281309000431 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 281309000432 Elongation Factor G, domain II; Region: EFG_II; pfam14492 281309000433 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 281309000434 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 281309000435 elongation factor Tu; Reviewed; Region: PRK00049 281309000436 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 281309000437 G1 box; other site 281309000438 GEF interaction site [polypeptide binding]; other site 281309000439 GTP/Mg2+ binding site [chemical binding]; other site 281309000440 Switch I region; other site 281309000441 G2 box; other site 281309000442 G3 box; other site 281309000443 Switch II region; other site 281309000444 G4 box; other site 281309000445 G5 box; other site 281309000446 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 281309000447 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 281309000448 Antibiotic Binding Site [chemical binding]; other site 281309000449 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 281309000450 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 281309000451 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 281309000452 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 281309000453 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 281309000454 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 281309000455 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 281309000456 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 281309000457 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 281309000458 putative translocon binding site; other site 281309000459 protein-rRNA interface [nucleotide binding]; other site 281309000460 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 281309000461 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 281309000462 G-X-X-G motif; other site 281309000463 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 281309000464 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 281309000465 23S rRNA interface [nucleotide binding]; other site 281309000466 5S rRNA interface [nucleotide binding]; other site 281309000467 putative antibiotic binding site [chemical binding]; other site 281309000468 L25 interface [polypeptide binding]; other site 281309000469 L27 interface [polypeptide binding]; other site 281309000470 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 281309000471 23S rRNA interface [nucleotide binding]; other site 281309000472 putative translocon interaction site; other site 281309000473 signal recognition particle (SRP54) interaction site; other site 281309000474 L23 interface [polypeptide binding]; other site 281309000475 trigger factor interaction site; other site 281309000476 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 281309000477 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 281309000478 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 281309000479 RNA binding site [nucleotide binding]; other site 281309000480 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 281309000481 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 281309000482 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 281309000483 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 281309000484 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 281309000485 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 281309000486 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 281309000487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 281309000488 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 281309000489 5S rRNA interface [nucleotide binding]; other site 281309000490 L27 interface [polypeptide binding]; other site 281309000491 23S rRNA interface [nucleotide binding]; other site 281309000492 L5 interface [polypeptide binding]; other site 281309000493 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 281309000494 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 281309000495 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 281309000496 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 281309000497 23S rRNA binding site [nucleotide binding]; other site 281309000498 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 281309000499 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 281309000500 SecY translocase; Region: SecY; pfam00344 281309000501 adenylate kinase; Reviewed; Region: adk; PRK00279 281309000502 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 281309000503 AMP-binding site [chemical binding]; other site 281309000504 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 281309000505 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 281309000506 active site 281309000507 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 281309000508 rRNA binding site [nucleotide binding]; other site 281309000509 predicted 30S ribosome binding site; other site 281309000510 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 281309000511 30S ribosomal protein S11; Validated; Region: PRK05309 281309000512 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 281309000513 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 281309000514 alphaNTD - beta interaction site [polypeptide binding]; other site 281309000515 alphaNTD homodimer interface [polypeptide binding]; other site 281309000516 alphaNTD - beta' interaction site [polypeptide binding]; other site 281309000517 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 281309000518 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 281309000519 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 281309000520 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281309000521 Walker A/P-loop; other site 281309000522 ATP binding site [chemical binding]; other site 281309000523 Q-loop/lid; other site 281309000524 ABC transporter signature motif; other site 281309000525 Walker B; other site 281309000526 D-loop; other site 281309000527 H-loop/switch region; other site 281309000528 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 281309000529 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281309000530 Walker A/P-loop; other site 281309000531 ATP binding site [chemical binding]; other site 281309000532 Q-loop/lid; other site 281309000533 ABC transporter signature motif; other site 281309000534 Walker B; other site 281309000535 D-loop; other site 281309000536 H-loop/switch region; other site 281309000537 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 281309000538 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 281309000539 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 281309000540 dimerization interface 3.5A [polypeptide binding]; other site 281309000541 active site 281309000542 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 281309000543 23S rRNA interface [nucleotide binding]; other site 281309000544 L3 interface [polypeptide binding]; other site 281309000545 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 281309000546 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 281309000547 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 281309000548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 281309000549 active site 281309000550 metal binding site [ion binding]; metal-binding site 281309000551 Domain of unknown function DUF59; Region: DUF59; cl00941 281309000552 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 281309000553 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 281309000554 Walker A motif; other site 281309000555 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 281309000556 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309000557 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 281309000558 NodB motif; other site 281309000559 putative active site [active] 281309000560 putative catalytic site [active] 281309000561 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 281309000562 Arginase family; Region: Arginase; cd09989 281309000563 active site 281309000564 Mn binding site [ion binding]; other site 281309000565 oligomer interface [polypeptide binding]; other site 281309000566 Uncharacterized conserved protein [Function unknown]; Region: COG1624 281309000567 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 281309000568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 281309000569 YbbR-like protein; Region: YbbR; pfam07949 281309000570 YbbR-like protein; Region: YbbR; pfam07949 281309000571 YbbR-like protein; Region: YbbR; pfam07949 281309000572 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 281309000573 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 281309000574 active site 281309000575 substrate binding site [chemical binding]; other site 281309000576 metal binding site [ion binding]; metal-binding site 281309000577 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 281309000578 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 281309000579 glutaminase active site [active] 281309000580 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 281309000581 dimer interface [polypeptide binding]; other site 281309000582 active site 281309000583 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 281309000584 dimer interface [polypeptide binding]; other site 281309000585 active site 281309000586 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309000587 Protein of unknown function (DUF986); Region: DUF986; cl01983 281309000588 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309000589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309000590 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281309000591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309000592 DNA-binding site [nucleotide binding]; DNA binding site 281309000593 FCD domain; Region: FCD; pfam07729 281309000594 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 281309000595 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 281309000596 N- and C-terminal domain interface [polypeptide binding]; other site 281309000597 active site 281309000598 catalytic site [active] 281309000599 metal binding site [ion binding]; metal-binding site 281309000600 carbohydrate binding site [chemical binding]; other site 281309000601 ATP binding site [chemical binding]; other site 281309000602 gluconate transporter; Region: gntP; TIGR00791 281309000603 GntP family permease; Region: GntP_permease; pfam02447 281309000604 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 281309000605 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 281309000606 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 281309000607 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 281309000608 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 281309000609 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 281309000610 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 281309000611 Predicted membrane protein [Function unknown]; Region: COG2259 281309000612 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 281309000613 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 281309000614 classical (c) SDRs; Region: SDR_c; cd05233 281309000615 NAD(P) binding site [chemical binding]; other site 281309000616 active site 281309000617 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309000618 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 281309000619 putative NAD(P) binding site [chemical binding]; other site 281309000620 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 281309000621 FAD binding domain; Region: FAD_binding_4; pfam01565 281309000622 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 281309000623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309000625 putative substrate translocation pore; other site 281309000626 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 281309000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309000628 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 281309000629 putative substrate translocation pore; other site 281309000630 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 281309000631 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 281309000632 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281309000633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309000634 dimer interface [polypeptide binding]; other site 281309000635 conserved gate region; other site 281309000636 putative PBP binding loops; other site 281309000637 ABC-ATPase subunit interface; other site 281309000638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309000639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309000640 dimer interface [polypeptide binding]; other site 281309000641 conserved gate region; other site 281309000642 putative PBP binding loops; other site 281309000643 ABC-ATPase subunit interface; other site 281309000644 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 281309000645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309000646 Walker A/P-loop; other site 281309000647 ATP binding site [chemical binding]; other site 281309000648 Q-loop/lid; other site 281309000649 ABC transporter signature motif; other site 281309000650 Walker B; other site 281309000651 D-loop; other site 281309000652 H-loop/switch region; other site 281309000653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309000654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 281309000655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309000656 Walker A/P-loop; other site 281309000657 ATP binding site [chemical binding]; other site 281309000658 Q-loop/lid; other site 281309000659 ABC transporter signature motif; other site 281309000660 Walker B; other site 281309000661 D-loop; other site 281309000662 H-loop/switch region; other site 281309000663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309000664 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309000665 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309000666 peptide binding site [polypeptide binding]; other site 281309000667 YusW-like protein; Region: YusW; pfam14039 281309000668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309000669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 281309000670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309000671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309000672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309000673 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 281309000674 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 281309000675 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309000676 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309000677 peptide binding site [polypeptide binding]; other site 281309000678 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309000679 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309000680 peptide binding site [polypeptide binding]; other site 281309000681 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309000682 active site 281309000683 catalytic tetrad [active] 281309000684 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 281309000685 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 281309000686 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 281309000687 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 281309000688 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 281309000689 Sugar transport protein; Region: Sugar_transport; pfam06800 281309000690 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 281309000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309000692 dimer interface [polypeptide binding]; other site 281309000693 conserved gate region; other site 281309000694 putative PBP binding loops; other site 281309000695 ABC-ATPase subunit interface; other site 281309000696 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 281309000697 DNA binding domain, excisionase family; Region: excise; TIGR01764 281309000698 PBP superfamily domain; Region: PBP_like; pfam12727 281309000699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309000700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309000701 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 281309000702 putative dimerization interface [polypeptide binding]; other site 281309000703 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309000704 EamA-like transporter family; Region: EamA; pfam00892 281309000705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 281309000706 putative acyl-acceptor binding pocket; other site 281309000707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309000708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309000709 DNA binding site [nucleotide binding] 281309000710 domain linker motif; other site 281309000711 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 281309000712 putative ligand binding site [chemical binding]; other site 281309000713 putative dimerization interface [polypeptide binding]; other site 281309000714 Bacterial PH domain; Region: bPH_3; pfam14470 281309000715 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309000716 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309000717 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309000718 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309000719 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 281309000720 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 281309000721 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 281309000722 active site 281309000723 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 281309000724 NodB motif; other site 281309000725 putative active site [active] 281309000726 putative catalytic site [active] 281309000727 putative Zn binding site [ion binding]; other site 281309000728 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 281309000729 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 281309000730 lysozyme catalytic site [active] 281309000731 catalytic residue [active] 281309000732 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 281309000733 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 281309000734 nucleotide binding site/active site [active] 281309000735 HIT family signature motif; other site 281309000736 catalytic residue [active] 281309000737 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309000738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309000739 ABC transporter; Region: ABC_tran_2; pfam12848 281309000740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309000741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 281309000742 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 281309000743 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281309000744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309000745 dimer interface [polypeptide binding]; other site 281309000746 conserved gate region; other site 281309000747 putative PBP binding loops; other site 281309000748 ABC-ATPase subunit interface; other site 281309000749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309000750 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 281309000751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309000752 dimer interface [polypeptide binding]; other site 281309000753 conserved gate region; other site 281309000754 putative PBP binding loops; other site 281309000755 ABC-ATPase subunit interface; other site 281309000756 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 281309000757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309000758 Walker A/P-loop; other site 281309000759 ATP binding site [chemical binding]; other site 281309000760 Q-loop/lid; other site 281309000761 ABC transporter signature motif; other site 281309000762 Walker B; other site 281309000763 D-loop; other site 281309000764 H-loop/switch region; other site 281309000765 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309000766 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 281309000767 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309000768 Walker A/P-loop; other site 281309000769 ATP binding site [chemical binding]; other site 281309000770 Q-loop/lid; other site 281309000771 ABC transporter signature motif; other site 281309000772 Walker B; other site 281309000773 D-loop; other site 281309000774 H-loop/switch region; other site 281309000775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309000776 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 281309000777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309000778 active site 281309000779 motif I; other site 281309000780 motif II; other site 281309000781 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309000782 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 281309000783 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 281309000784 dimer interface [polypeptide binding]; other site 281309000785 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 281309000786 active site 281309000787 Fe binding site [ion binding]; other site 281309000788 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 281309000789 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 281309000790 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 281309000791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309000792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309000793 putative substrate translocation pore; other site 281309000794 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 281309000795 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 281309000796 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 281309000797 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 281309000798 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281309000799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309000800 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309000801 helicase 45; Provisional; Region: PTZ00424 281309000802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 281309000803 ATP binding site [chemical binding]; other site 281309000804 Mg++ binding site [ion binding]; other site 281309000805 motif III; other site 281309000806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309000807 nucleotide binding region [chemical binding]; other site 281309000808 ATP-binding site [chemical binding]; other site 281309000809 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 281309000810 Rhomboid family; Region: Rhomboid; pfam01694 281309000811 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 281309000812 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 281309000813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 281309000814 alanine racemase; Reviewed; Region: alr; PRK00053 281309000815 active site 281309000816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281309000817 dimer interface [polypeptide binding]; other site 281309000818 substrate binding site [chemical binding]; other site 281309000819 catalytic residues [active] 281309000820 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 281309000821 PemK-like protein; Region: PemK; pfam02452 281309000822 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 281309000823 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 281309000824 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 281309000825 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 281309000826 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 281309000827 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 281309000828 RNA binding site [nucleotide binding]; other site 281309000829 hypothetical protein; Provisional; Region: PRK04351 281309000830 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 281309000831 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 281309000832 Glycoprotease family; Region: Peptidase_M22; pfam00814 281309000833 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 281309000834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309000835 Coenzyme A binding pocket [chemical binding]; other site 281309000836 UGMP family protein; Validated; Region: PRK09604 281309000837 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 281309000838 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 281309000839 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309000840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309000841 ABC transporter; Region: ABC_tran_2; pfam12848 281309000842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309000843 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 281309000844 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 281309000845 CoA binding domain; Region: CoA_binding; pfam02629 281309000846 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 281309000847 CAAX protease self-immunity; Region: Abi; pfam02517 281309000848 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 281309000849 oligomerisation interface [polypeptide binding]; other site 281309000850 mobile loop; other site 281309000851 roof hairpin; other site 281309000852 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 281309000853 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 281309000854 ring oligomerisation interface [polypeptide binding]; other site 281309000855 ATP/Mg binding site [chemical binding]; other site 281309000856 stacking interactions; other site 281309000857 hinge regions; other site 281309000858 GMP synthase; Reviewed; Region: guaA; PRK00074 281309000859 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 281309000860 AMP/PPi binding site [chemical binding]; other site 281309000861 candidate oxyanion hole; other site 281309000862 catalytic triad [active] 281309000863 potential glutamine specificity residues [chemical binding]; other site 281309000864 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 281309000865 ATP Binding subdomain [chemical binding]; other site 281309000866 Ligand Binding sites [chemical binding]; other site 281309000867 Dimerization subdomain; other site 281309000868 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 281309000869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309000870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309000871 active site 281309000872 phosphorylation site [posttranslational modification] 281309000873 intermolecular recognition site; other site 281309000874 dimerization interface [polypeptide binding]; other site 281309000875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309000876 DNA binding site [nucleotide binding] 281309000877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309000878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309000879 dimerization interface [polypeptide binding]; other site 281309000880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309000881 dimer interface [polypeptide binding]; other site 281309000882 phosphorylation site [posttranslational modification] 281309000883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309000884 ATP binding site [chemical binding]; other site 281309000885 Mg2+ binding site [ion binding]; other site 281309000886 G-X-G motif; other site 281309000887 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 281309000888 catalytic residues [active] 281309000889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309000890 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309000891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309000892 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309000893 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 281309000894 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281309000895 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309000896 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 281309000897 Walker A/P-loop; other site 281309000898 ATP binding site [chemical binding]; other site 281309000899 Q-loop/lid; other site 281309000900 ABC transporter signature motif; other site 281309000901 Walker B; other site 281309000902 D-loop; other site 281309000903 H-loop/switch region; other site 281309000904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309000905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309000906 dimer interface [polypeptide binding]; other site 281309000907 phosphorylation site [posttranslational modification] 281309000908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309000909 ATP binding site [chemical binding]; other site 281309000910 Mg2+ binding site [ion binding]; other site 281309000911 G-X-G motif; other site 281309000912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309000913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309000914 active site 281309000915 phosphorylation site [posttranslational modification] 281309000916 intermolecular recognition site; other site 281309000917 dimerization interface [polypeptide binding]; other site 281309000918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309000919 DNA binding site [nucleotide binding] 281309000920 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309000921 EamA-like transporter family; Region: EamA; pfam00892 281309000922 EamA-like transporter family; Region: EamA; pfam00892 281309000923 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 281309000924 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 281309000925 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 281309000926 ATP-grasp domain; Region: ATP-grasp; pfam02222 281309000927 adenylosuccinate lyase; Provisional; Region: PRK07492 281309000928 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 281309000929 tetramer interface [polypeptide binding]; other site 281309000930 active site 281309000931 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 281309000932 ATP binding site [chemical binding]; other site 281309000933 active site 281309000934 substrate binding site [chemical binding]; other site 281309000935 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 281309000936 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 281309000937 putative active site [active] 281309000938 catalytic triad [active] 281309000939 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 281309000940 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 281309000941 dimerization interface [polypeptide binding]; other site 281309000942 ATP binding site [chemical binding]; other site 281309000943 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 281309000944 dimerization interface [polypeptide binding]; other site 281309000945 ATP binding site [chemical binding]; other site 281309000946 amidophosphoribosyltransferase; Provisional; Region: PRK06781 281309000947 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 281309000948 active site 281309000949 tetramer interface [polypeptide binding]; other site 281309000950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309000951 active site 281309000952 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 281309000953 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 281309000954 dimerization interface [polypeptide binding]; other site 281309000955 putative ATP binding site [chemical binding]; other site 281309000956 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 281309000957 active site 281309000958 substrate binding site [chemical binding]; other site 281309000959 cosubstrate binding site; other site 281309000960 catalytic site [active] 281309000961 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 281309000962 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 281309000963 purine monophosphate binding site [chemical binding]; other site 281309000964 dimer interface [polypeptide binding]; other site 281309000965 putative catalytic residues [active] 281309000966 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 281309000967 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 281309000968 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 281309000969 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 281309000970 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 281309000971 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 281309000972 prohibitin homologues; Region: PHB; smart00244 281309000973 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 281309000974 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 281309000975 substrate binding site [chemical binding]; other site 281309000976 putative active site [active] 281309000977 dimer interface [polypeptide binding]; other site 281309000978 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 281309000979 Part of AAA domain; Region: AAA_19; pfam13245 281309000980 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 281309000981 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 281309000982 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 281309000983 nucleotide binding pocket [chemical binding]; other site 281309000984 K-X-D-G motif; other site 281309000985 catalytic site [active] 281309000986 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 281309000987 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 281309000988 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 281309000989 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 281309000990 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 281309000991 Dimer interface [polypeptide binding]; other site 281309000992 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 281309000993 putative dimer interface [polypeptide binding]; other site 281309000994 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 281309000995 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 281309000996 putative dimer interface [polypeptide binding]; other site 281309000997 hypothetical protein; Provisional; Region: PRK10621 281309000998 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 281309000999 Glutamate binding site [chemical binding]; other site 281309001000 homodimer interface [polypeptide binding]; other site 281309001001 NAD binding site [chemical binding]; other site 281309001002 catalytic residues [active] 281309001003 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 281309001004 catalytic triad [active] 281309001005 conserved cis-peptide bond; other site 281309001006 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 281309001007 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 281309001008 Walker A/P-loop; other site 281309001009 ATP binding site [chemical binding]; other site 281309001010 Q-loop/lid; other site 281309001011 ABC transporter signature motif; other site 281309001012 Walker B; other site 281309001013 D-loop; other site 281309001014 H-loop/switch region; other site 281309001015 NIL domain; Region: NIL; pfam09383 281309001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001017 dimer interface [polypeptide binding]; other site 281309001018 conserved gate region; other site 281309001019 putative PBP binding loops; other site 281309001020 ABC-ATPase subunit interface; other site 281309001021 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 281309001022 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 281309001023 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 281309001024 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 281309001025 P loop; other site 281309001026 Nucleotide binding site [chemical binding]; other site 281309001027 DTAP/Switch II; other site 281309001028 Switch I; other site 281309001029 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 281309001030 putative dimer interface [polypeptide binding]; other site 281309001031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309001032 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309001033 yiaA/B two helix domain; Region: YiaAB; pfam05360 281309001034 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 281309001035 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 281309001036 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 281309001037 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 281309001038 GatB domain; Region: GatB_Yqey; pfam02637 281309001039 putative lipid kinase; Reviewed; Region: PRK13337 281309001040 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 281309001041 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 281309001042 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 281309001043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309001044 motif II; other site 281309001045 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309001046 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309001047 inhibitor-cofactor binding pocket; inhibition site 281309001048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309001049 catalytic residue [active] 281309001050 PAS domain; Region: PAS_9; pfam13426 281309001051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309001052 putative active site [active] 281309001053 heme pocket [chemical binding]; other site 281309001054 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 281309001055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309001056 Walker A motif; other site 281309001057 ATP binding site [chemical binding]; other site 281309001058 Walker B motif; other site 281309001059 arginine finger; other site 281309001060 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 281309001061 tetramerization interface [polypeptide binding]; other site 281309001062 NAD(P) binding site [chemical binding]; other site 281309001063 catalytic residues [active] 281309001064 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 281309001065 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 281309001066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309001067 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 281309001068 putative active site [active] 281309001069 putative metal binding site [ion binding]; other site 281309001070 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309001071 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309001072 Nucleoside recognition; Region: Gate; pfam07670 281309001073 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309001074 TRAM domain; Region: TRAM; cl01282 281309001075 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 281309001076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309001077 S-adenosylmethionine binding site [chemical binding]; other site 281309001078 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 281309001079 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 281309001080 FMN binding site [chemical binding]; other site 281309001081 active site 281309001082 catalytic residues [active] 281309001083 substrate binding site [chemical binding]; other site 281309001084 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 281309001085 GAF domain; Region: GAF_3; pfam13492 281309001086 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 281309001087 PAS domain; Region: PAS; smart00091 281309001088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309001089 dimer interface [polypeptide binding]; other site 281309001090 phosphorylation site [posttranslational modification] 281309001091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309001092 ATP binding site [chemical binding]; other site 281309001093 Mg2+ binding site [ion binding]; other site 281309001094 G-X-G motif; other site 281309001095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 281309001096 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 281309001097 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 281309001098 Probable transposase; Region: OrfB_IS605; pfam01385 281309001099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309001100 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309001101 Protein of unknown function DUF45; Region: DUF45; pfam01863 281309001102 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 281309001103 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 281309001104 active site 281309001105 Predicted transcriptional regulator [Transcription]; Region: COG3355 281309001106 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 281309001107 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281309001108 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 281309001109 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309001110 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 281309001111 metal binding site [ion binding]; metal-binding site 281309001112 putative dimer interface [polypeptide binding]; other site 281309001113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309001114 S-adenosylmethionine binding site [chemical binding]; other site 281309001115 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 281309001116 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 281309001117 catalytic residue [active] 281309001118 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 281309001119 catalytic residues [active] 281309001120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309001121 peroxiredoxin; Region: AhpC; TIGR03137 281309001122 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 281309001123 dimer interface [polypeptide binding]; other site 281309001124 decamer (pentamer of dimers) interface [polypeptide binding]; other site 281309001125 catalytic triad [active] 281309001126 peroxidatic and resolving cysteines [active] 281309001127 5-methylribose kinase; Reviewed; Region: PRK12396 281309001128 Phosphotransferase enzyme family; Region: APH; pfam01636 281309001129 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 281309001130 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 281309001131 intersubunit interface [polypeptide binding]; other site 281309001132 active site 281309001133 Zn2+ binding site [ion binding]; other site 281309001134 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309001135 ABC-ATPase subunit interface; other site 281309001136 dimer interface [polypeptide binding]; other site 281309001137 putative PBP binding regions; other site 281309001138 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309001139 ABC-ATPase subunit interface; other site 281309001140 dimer interface [polypeptide binding]; other site 281309001141 putative PBP binding regions; other site 281309001142 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309001143 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 281309001144 putative ligand binding residues [chemical binding]; other site 281309001145 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 281309001146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309001147 DNA binding domain, excisionase family; Region: excise; TIGR01764 281309001148 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 281309001149 Sm and related proteins; Region: Sm_like; cl00259 281309001150 Sm1 motif; other site 281309001151 RNA binding site [nucleotide binding]; other site 281309001152 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 281309001153 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 281309001154 hypothetical protein; Provisional; Region: PRK06851 281309001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309001156 Walker A motif; other site 281309001157 ATP binding site [chemical binding]; other site 281309001158 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 281309001159 G1 box; other site 281309001160 GTP/Mg2+ binding site [chemical binding]; other site 281309001161 G2 box; other site 281309001162 Switch I region; other site 281309001163 G3 box; other site 281309001164 Switch II region; other site 281309001165 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 281309001166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309001167 putative substrate translocation pore; other site 281309001168 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 281309001169 FAD dependent oxidoreductase; Region: DAO; pfam01266 281309001170 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 281309001171 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 281309001172 [2Fe-2S] cluster binding site [ion binding]; other site 281309001173 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 281309001174 putative di-iron ligands [ion binding]; other site 281309001175 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 281309001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001177 dimer interface [polypeptide binding]; other site 281309001178 conserved gate region; other site 281309001179 putative PBP binding loops; other site 281309001180 ABC-ATPase subunit interface; other site 281309001181 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 281309001182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 281309001183 substrate binding pocket [chemical binding]; other site 281309001184 membrane-bound complex binding site; other site 281309001185 hinge residues; other site 281309001186 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 281309001187 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 281309001188 Walker A/P-loop; other site 281309001189 ATP binding site [chemical binding]; other site 281309001190 Q-loop/lid; other site 281309001191 ABC transporter signature motif; other site 281309001192 Walker B; other site 281309001193 D-loop; other site 281309001194 H-loop/switch region; other site 281309001195 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 281309001196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001197 dimerization interface [polypeptide binding]; other site 281309001198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309001199 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309001200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309001201 dimer interface [polypeptide binding]; other site 281309001202 putative CheW interface [polypeptide binding]; other site 281309001203 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 281309001204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001205 dimerization interface [polypeptide binding]; other site 281309001206 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309001207 dimer interface [polypeptide binding]; other site 281309001208 putative CheW interface [polypeptide binding]; other site 281309001209 Arginine repressor [Transcription]; Region: ArgR; COG1438 281309001210 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 281309001211 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 281309001212 arginine deiminase; Provisional; Region: PRK01388 281309001213 ornithine carbamoyltransferase; Validated; Region: PRK02102 281309001214 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 281309001215 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 281309001216 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 281309001217 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 281309001218 putative substrate binding site [chemical binding]; other site 281309001219 nucleotide binding site [chemical binding]; other site 281309001220 nucleotide binding site [chemical binding]; other site 281309001221 homodimer interface [polypeptide binding]; other site 281309001222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 281309001223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 281309001224 ligand binding site [chemical binding]; other site 281309001225 flexible hinge region; other site 281309001226 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 281309001227 putative switch regulator; other site 281309001228 non-specific DNA interactions [nucleotide binding]; other site 281309001229 DNA binding site [nucleotide binding] 281309001230 sequence specific DNA binding site [nucleotide binding]; other site 281309001231 putative cAMP binding site [chemical binding]; other site 281309001232 Phosphatidylinositol N-acetylglucosaminyltransferase; Region: GPI2; pfam06432 281309001233 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 281309001234 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 281309001235 Ca binding site [ion binding]; other site 281309001236 active site 281309001237 catalytic site [active] 281309001238 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309001239 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 281309001240 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309001241 active site turn [active] 281309001242 phosphorylation site [posttranslational modification] 281309001243 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 281309001244 putative catalytic site [active] 281309001245 putative metal binding site [ion binding]; other site 281309001246 putative phosphate binding site [ion binding]; other site 281309001247 Predicted membrane protein [Function unknown]; Region: COG1511 281309001248 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 281309001249 SEA domain; Region: SEA; cl02507 281309001250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309001251 DNA topoisomerase III; Provisional; Region: PRK07726 281309001252 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 281309001253 active site 281309001254 putative interdomain interaction site [polypeptide binding]; other site 281309001255 putative metal-binding site [ion binding]; other site 281309001256 putative nucleotide binding site [chemical binding]; other site 281309001257 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 281309001258 domain I; other site 281309001259 DNA binding groove [nucleotide binding] 281309001260 phosphate binding site [ion binding]; other site 281309001261 domain II; other site 281309001262 domain III; other site 281309001263 nucleotide binding site [chemical binding]; other site 281309001264 catalytic site [active] 281309001265 domain IV; other site 281309001266 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 281309001267 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 281309001268 substrate binding site [chemical binding]; other site 281309001269 multimerization interface [polypeptide binding]; other site 281309001270 ATP binding site [chemical binding]; other site 281309001271 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 281309001272 thiamine phosphate binding site [chemical binding]; other site 281309001273 active site 281309001274 pyrophosphate binding site [ion binding]; other site 281309001275 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 281309001276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001277 dimerization interface [polypeptide binding]; other site 281309001278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309001279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309001280 dimer interface [polypeptide binding]; other site 281309001281 putative CheW interface [polypeptide binding]; other site 281309001282 Domain of unknown function DUF77; Region: DUF77; pfam01910 281309001283 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 281309001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001285 dimer interface [polypeptide binding]; other site 281309001286 conserved gate region; other site 281309001287 putative PBP binding loops; other site 281309001288 ABC-ATPase subunit interface; other site 281309001289 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 281309001290 NMT1/THI5 like; Region: NMT1; pfam09084 281309001291 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 281309001292 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 281309001293 Walker A/P-loop; other site 281309001294 ATP binding site [chemical binding]; other site 281309001295 Q-loop/lid; other site 281309001296 ABC transporter signature motif; other site 281309001297 Walker B; other site 281309001298 D-loop; other site 281309001299 H-loop/switch region; other site 281309001300 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309001301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309001302 ABC transporter; Region: ABC_tran_2; pfam12848 281309001303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309001304 Glyco_18 domain; Region: Glyco_18; smart00636 281309001305 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 281309001306 active site 281309001307 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 281309001308 Interdomain contacts; other site 281309001309 Cytokine receptor motif; other site 281309001310 Cellulose binding domain; Region: CBM_2; pfam00553 281309001311 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 281309001312 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281309001313 catalytic residues [active] 281309001314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309001315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309001316 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 281309001317 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309001318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309001319 putative substrate translocation pore; other site 281309001320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309001321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309001322 non-specific DNA binding site [nucleotide binding]; other site 281309001323 salt bridge; other site 281309001324 sequence-specific DNA binding site [nucleotide binding]; other site 281309001325 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 281309001326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309001327 putative substrate translocation pore; other site 281309001328 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 281309001329 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 281309001330 YesK-like protein; Region: YesK; pfam14150 281309001331 prolyl-tRNA synthetase; Provisional; Region: PRK08661 281309001332 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 281309001333 dimer interface [polypeptide binding]; other site 281309001334 motif 1; other site 281309001335 active site 281309001336 motif 2; other site 281309001337 motif 3; other site 281309001338 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 281309001339 anticodon binding site; other site 281309001340 zinc-binding site [ion binding]; other site 281309001341 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281309001342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309001343 nucleotide binding site [chemical binding]; other site 281309001344 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 281309001345 putative metal binding site [ion binding]; other site 281309001346 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 281309001347 putative metal binding site [ion binding]; other site 281309001348 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 281309001349 putative metal binding site [ion binding]; other site 281309001350 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 281309001351 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 281309001352 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 281309001353 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 281309001354 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 281309001355 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 281309001356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309001357 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 281309001358 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 281309001359 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 281309001360 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 281309001361 Low molecular weight phosphatase family; Region: LMWPc; cd00115 281309001362 active site 281309001363 YtxH-like protein; Region: YtxH; pfam12732 281309001364 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 281309001365 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 281309001366 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 281309001367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309001368 Soluble P-type ATPase [General function prediction only]; Region: COG4087 281309001369 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309001370 EamA-like transporter family; Region: EamA; pfam00892 281309001371 EamA-like transporter family; Region: EamA; pfam00892 281309001372 YhhN-like protein; Region: YhhN; pfam07947 281309001373 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 281309001374 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281309001375 Catalytic site [active] 281309001376 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 281309001377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309001378 binding surface 281309001379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 281309001380 TPR motif; other site 281309001381 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309001382 Predicted membrane protein [Function unknown]; Region: COG2510 281309001383 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 281309001384 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 281309001385 calcium/proton exchanger (cax); Region: cax; TIGR00378 281309001386 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 281309001387 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 281309001388 YfkD-like protein; Region: YfkD; pfam14167 281309001389 Radical SAM superfamily; Region: Radical_SAM; pfam04055 281309001390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309001391 FeS/SAM binding site; other site 281309001392 YfkB-like domain; Region: YfkB; pfam08756 281309001393 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 281309001394 Fumarase C-terminus; Region: Fumerase_C; pfam05683 281309001395 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 281309001396 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 281309001397 NodB motif; other site 281309001398 active site 281309001399 catalytic site [active] 281309001400 Cd binding site [ion binding]; other site 281309001401 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 281309001402 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 281309001403 minor groove reading motif; other site 281309001404 helix-hairpin-helix signature motif; other site 281309001405 substrate binding pocket [chemical binding]; other site 281309001406 active site 281309001407 TRAM domain; Region: TRAM; pfam01938 281309001408 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 281309001409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309001410 S-adenosylmethionine binding site [chemical binding]; other site 281309001411 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 281309001412 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 281309001413 dimerization interface 3.5A [polypeptide binding]; other site 281309001414 active site 281309001415 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 281309001416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309001417 Walker A motif; other site 281309001418 ATP binding site [chemical binding]; other site 281309001419 Walker B motif; other site 281309001420 arginine finger; other site 281309001421 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 281309001422 hypothetical protein; Validated; Region: PRK06748 281309001423 S-methylmethionine transporter; Provisional; Region: PRK11387 281309001424 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309001425 acetylornithine deacetylase; Validated; Region: PRK08596 281309001426 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 281309001427 metal binding site [ion binding]; metal-binding site 281309001428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309001429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309001430 sequence-specific DNA binding site [nucleotide binding]; other site 281309001431 salt bridge; other site 281309001432 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 281309001433 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 281309001434 Domain of unknown function DUF; Region: DUF204; pfam02659 281309001435 Domain of unknown function DUF; Region: DUF204; pfam02659 281309001436 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 281309001437 glutaminase A; Region: Gln_ase; TIGR03814 281309001438 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 281309001439 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309001440 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309001441 active site turn [active] 281309001442 phosphorylation site [posttranslational modification] 281309001443 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309001444 Sm and related proteins; Region: Sm_like; cl00259 281309001445 heptamer interface [polypeptide binding]; other site 281309001446 Sm1 motif; other site 281309001447 hexamer interface [polypeptide binding]; other site 281309001448 RNA binding site [nucleotide binding]; other site 281309001449 Sm2 motif; other site 281309001450 Sm and related proteins; Region: Sm_like; cl00259 281309001451 heptamer interface [polypeptide binding]; other site 281309001452 Sm1 motif; other site 281309001453 hexamer interface [polypeptide binding]; other site 281309001454 RNA binding site [nucleotide binding]; other site 281309001455 Sm2 motif; other site 281309001456 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309001457 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 281309001458 active site 281309001459 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309001460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281309001461 active site 281309001462 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 281309001463 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 281309001464 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 281309001465 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 281309001466 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309001467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309001468 NAD(P) binding site [chemical binding]; other site 281309001469 active site 281309001470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309001471 active site 281309001472 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309001473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309001474 active site 281309001475 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 281309001476 Pyruvate formate lyase 1; Region: PFL1; cd01678 281309001477 coenzyme A binding site [chemical binding]; other site 281309001478 active site 281309001479 catalytic residues [active] 281309001480 glycine loop; other site 281309001481 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 281309001482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309001483 FeS/SAM binding site; other site 281309001484 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 281309001485 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 281309001486 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 281309001487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309001488 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 281309001489 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 281309001490 active site 281309001491 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 281309001492 TIGR01777 family protein; Region: yfcH 281309001493 putative NAD(P) binding site [chemical binding]; other site 281309001494 putative active site [active] 281309001495 recombination regulator RecX; Provisional; Region: recX; PRK14135 281309001496 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 281309001497 WVELL protein; Region: WVELL; pfam14043 281309001498 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 281309001499 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 281309001500 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 281309001501 minor groove reading motif; other site 281309001502 helix-hairpin-helix signature motif; other site 281309001503 substrate binding pocket [chemical binding]; other site 281309001504 active site 281309001505 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 281309001506 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 281309001507 DNA binding and oxoG recognition site [nucleotide binding] 281309001508 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 281309001509 YgaB-like protein; Region: YgaB; pfam14182 281309001510 hypothetical protein; Provisional; Region: PRK13662 281309001511 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309001512 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309001513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309001514 Walker A/P-loop; other site 281309001515 ATP binding site [chemical binding]; other site 281309001516 Q-loop/lid; other site 281309001517 ABC transporter signature motif; other site 281309001518 Walker B; other site 281309001519 D-loop; other site 281309001520 H-loop/switch region; other site 281309001521 Predicted membrane protein [Function unknown]; Region: COG4129 281309001522 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 281309001523 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 281309001524 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 281309001525 active site 281309001526 dimer interface [polypeptide binding]; other site 281309001527 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 281309001528 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 281309001529 active site 281309001530 FMN binding site [chemical binding]; other site 281309001531 substrate binding site [chemical binding]; other site 281309001532 3Fe-4S cluster binding site [ion binding]; other site 281309001533 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 281309001534 domain_subunit interface; other site 281309001535 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 281309001536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309001537 inhibitor-cofactor binding pocket; inhibition site 281309001538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309001539 catalytic residue [active] 281309001540 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 281309001541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309001542 Walker A/P-loop; other site 281309001543 ATP binding site [chemical binding]; other site 281309001544 Q-loop/lid; other site 281309001545 ABC transporter signature motif; other site 281309001546 Walker B; other site 281309001547 D-loop; other site 281309001548 H-loop/switch region; other site 281309001549 ABC-2 type transporter; Region: ABC2_membrane; cl17235 281309001550 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 281309001551 Ion channel; Region: Ion_trans_2; pfam07885 281309001552 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 281309001553 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 281309001554 catalytic triad [active] 281309001555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 281309001556 metal binding site 2 [ion binding]; metal-binding site 281309001557 putative DNA binding helix; other site 281309001558 metal binding site 1 [ion binding]; metal-binding site 281309001559 dimer interface [polypeptide binding]; other site 281309001560 structural Zn2+ binding site [ion binding]; other site 281309001561 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 281309001562 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 281309001563 hypothetical protein; Provisional; Region: PRK12378 281309001564 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 281309001565 nudix motif; other site 281309001566 Transglycosylase; Region: Transgly; pfam00912 281309001567 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 281309001568 Thioredoxin; Region: Thioredoxin_4; pfam13462 281309001569 epoxyqueuosine reductase; Region: TIGR00276 281309001570 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 281309001571 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 281309001572 HEAT-like repeat; Region: HEAT_EZ; pfam13513 281309001573 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 281309001574 Putative amidase domain; Region: Amidase_6; pfam12671 281309001575 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 281309001576 PAS fold; Region: PAS_4; pfam08448 281309001577 PAS domain S-box; Region: sensory_box; TIGR00229 281309001578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309001579 putative active site [active] 281309001580 heme pocket [chemical binding]; other site 281309001581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309001582 metal binding site [ion binding]; metal-binding site 281309001583 active site 281309001584 I-site; other site 281309001585 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309001586 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 281309001587 PrkA AAA domain; Region: AAA_PrkA; smart00763 281309001588 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 281309001589 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 281309001590 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309001591 heme-binding site [chemical binding]; other site 281309001592 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001593 Leucine rich repeat; Region: LRR_8; pfam13855 281309001594 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001595 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001596 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001597 Leucine rich repeat; Region: LRR_8; pfam13855 281309001598 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001599 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001600 Leucine rich repeat; Region: LRR_8; pfam13855 281309001601 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001602 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309001603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309001604 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309001605 Coenzyme A binding pocket [chemical binding]; other site 281309001606 BCCT family transporter; Region: BCCT; pfam02028 281309001607 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 281309001608 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 281309001609 FOG: PKD repeat [General function prediction only]; Region: COG3291 281309001610 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 281309001611 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 281309001612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 281309001613 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 281309001614 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 281309001615 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 281309001616 Cache domain; Region: Cache_1; pfam02743 281309001617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001618 dimerization interface [polypeptide binding]; other site 281309001619 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309001620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309001621 dimer interface [polypeptide binding]; other site 281309001622 putative CheW interface [polypeptide binding]; other site 281309001623 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 281309001624 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 281309001625 PAS domain; Region: PAS; smart00091 281309001626 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 281309001627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309001628 ATP binding site [chemical binding]; other site 281309001629 Mg2+ binding site [ion binding]; other site 281309001630 G-X-G motif; other site 281309001631 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 281309001632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309001633 active site 281309001634 phosphorylation site [posttranslational modification] 281309001635 intermolecular recognition site; other site 281309001636 dimerization interface [polypeptide binding]; other site 281309001637 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 281309001638 Citrate transporter; Region: CitMHS; pfam03600 281309001639 hypothetical protein; Provisional; Region: PRK12784 281309001640 NosL; Region: NosL; cl01769 281309001641 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309001642 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 281309001643 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309001644 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281309001645 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309001646 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 281309001647 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 281309001648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309001649 Walker A/P-loop; other site 281309001650 ATP binding site [chemical binding]; other site 281309001651 Q-loop/lid; other site 281309001652 ABC transporter signature motif; other site 281309001653 Walker B; other site 281309001654 D-loop; other site 281309001655 H-loop/switch region; other site 281309001656 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 281309001657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001658 dimer interface [polypeptide binding]; other site 281309001659 conserved gate region; other site 281309001660 putative PBP binding loops; other site 281309001661 ABC-ATPase subunit interface; other site 281309001662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281309001663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001664 dimer interface [polypeptide binding]; other site 281309001665 conserved gate region; other site 281309001666 putative PBP binding loops; other site 281309001667 ABC-ATPase subunit interface; other site 281309001668 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281309001669 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 281309001670 putative protein phosphatase; Region: PHA02239 281309001671 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 281309001672 active site 281309001673 metal binding site [ion binding]; metal-binding site 281309001674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309001675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309001676 active site 281309001677 phosphorylation site [posttranslational modification] 281309001678 intermolecular recognition site; other site 281309001679 dimerization interface [polypeptide binding]; other site 281309001680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309001681 DNA binding site [nucleotide binding] 281309001682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309001683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309001684 dimer interface [polypeptide binding]; other site 281309001685 phosphorylation site [posttranslational modification] 281309001686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309001687 ATP binding site [chemical binding]; other site 281309001688 Mg2+ binding site [ion binding]; other site 281309001689 G-X-G motif; other site 281309001690 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 281309001691 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 281309001692 putative active site [active] 281309001693 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 281309001694 Cache domain; Region: Cache_1; pfam02743 281309001695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001696 dimerization interface [polypeptide binding]; other site 281309001697 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309001698 dimer interface [polypeptide binding]; other site 281309001699 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309001700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309001701 dimer interface [polypeptide binding]; other site 281309001702 putative CheW interface [polypeptide binding]; other site 281309001703 sensory histidine kinase DcuS; Provisional; Region: PRK11086 281309001704 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 281309001705 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 281309001706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309001707 ATP binding site [chemical binding]; other site 281309001708 Mg2+ binding site [ion binding]; other site 281309001709 G-X-G motif; other site 281309001710 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 281309001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309001712 active site 281309001713 phosphorylation site [posttranslational modification] 281309001714 intermolecular recognition site; other site 281309001715 dimerization interface [polypeptide binding]; other site 281309001716 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 281309001717 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 281309001718 Malic enzyme, N-terminal domain; Region: malic; pfam00390 281309001719 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 281309001720 putative NAD(P) binding site [chemical binding]; other site 281309001721 EamA-like transporter family; Region: EamA; pfam00892 281309001722 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 281309001723 EamA-like transporter family; Region: EamA; pfam00892 281309001724 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309001725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309001726 DNA-binding site [nucleotide binding]; DNA binding site 281309001727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309001728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309001729 homodimer interface [polypeptide binding]; other site 281309001730 catalytic residue [active] 281309001731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309001732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309001733 Coenzyme A binding pocket [chemical binding]; other site 281309001734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309001735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309001736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001737 dimerization interface [polypeptide binding]; other site 281309001738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309001739 dimer interface [polypeptide binding]; other site 281309001740 phosphorylation site [posttranslational modification] 281309001741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309001742 ATP binding site [chemical binding]; other site 281309001743 Mg2+ binding site [ion binding]; other site 281309001744 G-X-G motif; other site 281309001745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309001747 active site 281309001748 phosphorylation site [posttranslational modification] 281309001749 intermolecular recognition site; other site 281309001750 dimerization interface [polypeptide binding]; other site 281309001751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309001752 DNA binding site [nucleotide binding] 281309001753 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309001754 Arrestin_N terminal like; Region: LDB19; pfam13002 281309001755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309001756 Coenzyme A binding pocket [chemical binding]; other site 281309001757 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 281309001758 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 281309001759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 281309001760 catalytic loop [active] 281309001761 iron binding site [ion binding]; other site 281309001762 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 281309001763 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 281309001764 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 281309001765 [4Fe-4S] binding site [ion binding]; other site 281309001766 molybdopterin cofactor binding site; other site 281309001767 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 281309001768 molybdopterin cofactor binding site; other site 281309001769 Uncharacterized conserved protein [Function unknown]; Region: COG2427 281309001770 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 281309001771 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 281309001772 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 281309001773 putative active site [active] 281309001774 catalytic site [active] 281309001775 putative metal binding site [ion binding]; other site 281309001776 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 281309001777 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 281309001778 hexamer interface [polypeptide binding]; other site 281309001779 ligand binding site [chemical binding]; other site 281309001780 putative active site [active] 281309001781 NAD(P) binding site [chemical binding]; other site 281309001782 amino acid transporter; Region: 2A0306; TIGR00909 281309001783 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309001784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309001785 dimerization interface [polypeptide binding]; other site 281309001786 putative DNA binding site [nucleotide binding]; other site 281309001787 putative Zn2+ binding site [ion binding]; other site 281309001788 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281309001789 metal-binding site [ion binding] 281309001790 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 281309001791 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281309001792 metal-binding site [ion binding] 281309001793 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309001794 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 281309001795 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 281309001796 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 281309001797 active site 281309001798 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309001799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309001800 non-specific DNA binding site [nucleotide binding]; other site 281309001801 salt bridge; other site 281309001802 sequence-specific DNA binding site [nucleotide binding]; other site 281309001803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309001804 binding surface 281309001805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309001806 TPR motif; other site 281309001807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309001808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309001809 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 281309001810 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 281309001811 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 281309001812 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 281309001813 active site 281309001814 Zn binding site [ion binding]; other site 281309001815 Uncharacterized conserved protein [Function unknown]; Region: COG0398 281309001816 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 281309001817 Transcriptional regulator PadR-like family; Region: PadR; cl17335 281309001818 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 281309001819 VanW like protein; Region: VanW; pfam04294 281309001820 Transposase; Region: HTH_Tnp_1; cl17663 281309001821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309001822 HTH-like domain; Region: HTH_21; pfam13276 281309001823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 281309001824 Integrase core domain; Region: rve; pfam00665 281309001825 Integrase core domain; Region: rve_2; pfam13333 281309001826 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 281309001827 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309001828 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309001829 Nucleoside recognition; Region: Gate; pfam07670 281309001830 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309001831 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 281309001832 putative metal binding site [ion binding]; other site 281309001833 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281309001834 Domain of unknown function DUF21; Region: DUF21; pfam01595 281309001835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281309001836 Transporter associated domain; Region: CorC_HlyC; smart01091 281309001837 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 281309001838 Aspartase; Region: Aspartase; cd01357 281309001839 active sites [active] 281309001840 tetramer interface [polypeptide binding]; other site 281309001841 L-lactate permease; Region: Lactate_perm; cl00701 281309001842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309001843 dimerization interface [polypeptide binding]; other site 281309001844 putative DNA binding site [nucleotide binding]; other site 281309001845 putative Zn2+ binding site [ion binding]; other site 281309001846 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 281309001847 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 281309001848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309001849 putative substrate translocation pore; other site 281309001850 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309001851 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 281309001852 siderophore binding site; other site 281309001853 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309001854 ABC-ATPase subunit interface; other site 281309001855 dimer interface [polypeptide binding]; other site 281309001856 putative PBP binding regions; other site 281309001857 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309001858 ABC-ATPase subunit interface; other site 281309001859 dimer interface [polypeptide binding]; other site 281309001860 putative PBP binding regions; other site 281309001861 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281309001862 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281309001863 Walker A/P-loop; other site 281309001864 ATP binding site [chemical binding]; other site 281309001865 Q-loop/lid; other site 281309001866 ABC transporter signature motif; other site 281309001867 Walker B; other site 281309001868 D-loop; other site 281309001869 H-loop/switch region; other site 281309001870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309001871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309001872 S-adenosylmethionine binding site [chemical binding]; other site 281309001873 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 281309001874 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 281309001875 substrate-cofactor binding pocket; other site 281309001876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309001877 catalytic residue [active] 281309001878 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309001879 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 281309001880 NAD binding site [chemical binding]; other site 281309001881 homodimer interface [polypeptide binding]; other site 281309001882 active site 281309001883 putative substrate binding site [chemical binding]; other site 281309001884 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309001885 active site 281309001886 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 281309001887 nudix motif; other site 281309001888 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 281309001889 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 281309001890 metal ion-dependent adhesion site (MIDAS); other site 281309001891 MoxR-like ATPases [General function prediction only]; Region: COG0714 281309001892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309001893 Walker A motif; other site 281309001894 ATP binding site [chemical binding]; other site 281309001895 Walker B motif; other site 281309001896 arginine finger; other site 281309001897 cardiolipin synthetase; Reviewed; Region: PRK12452 281309001898 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 281309001899 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 281309001900 putative active site [active] 281309001901 catalytic site [active] 281309001902 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 281309001903 putative active site [active] 281309001904 catalytic site [active] 281309001905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309001906 PAS domain; Region: PAS_9; pfam13426 281309001907 putative active site [active] 281309001908 heme pocket [chemical binding]; other site 281309001909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309001910 metal binding site [ion binding]; metal-binding site 281309001911 active site 281309001912 I-site; other site 281309001913 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309001914 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 281309001915 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309001916 Spore germination protein; Region: Spore_permease; cl17796 281309001917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309001918 DNA-binding site [nucleotide binding]; DNA binding site 281309001919 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 281309001920 UTRA domain; Region: UTRA; pfam07702 281309001921 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 281309001922 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309001923 active site turn [active] 281309001924 phosphorylation site [posttranslational modification] 281309001925 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309001926 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 281309001927 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 281309001928 Ca binding site [ion binding]; other site 281309001929 active site 281309001930 catalytic site [active] 281309001931 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 281309001932 Spore germination protein; Region: Spore_permease; cl17796 281309001933 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309001934 CAAX protease self-immunity; Region: Abi; pfam02517 281309001935 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309001936 Phosphotransferase enzyme family; Region: APH; pfam01636 281309001937 active site 281309001938 ATP binding site [chemical binding]; other site 281309001939 substrate binding site [chemical binding]; other site 281309001940 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 281309001941 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 281309001942 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 281309001943 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 281309001944 Walker A/P-loop; other site 281309001945 ATP binding site [chemical binding]; other site 281309001946 Q-loop/lid; other site 281309001947 ABC transporter signature motif; other site 281309001948 Walker B; other site 281309001949 D-loop; other site 281309001950 H-loop/switch region; other site 281309001951 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 281309001952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 281309001953 substrate binding pocket [chemical binding]; other site 281309001954 membrane-bound complex binding site; other site 281309001955 hinge residues; other site 281309001956 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 281309001957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001958 dimer interface [polypeptide binding]; other site 281309001959 conserved gate region; other site 281309001960 putative PBP binding loops; other site 281309001961 ABC-ATPase subunit interface; other site 281309001962 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 281309001963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309001964 dimer interface [polypeptide binding]; other site 281309001965 conserved gate region; other site 281309001966 putative PBP binding loops; other site 281309001967 ABC-ATPase subunit interface; other site 281309001968 S-methylmethionine transporter; Provisional; Region: PRK11387 281309001969 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309001970 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 281309001971 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 281309001972 nucleotide binding site/active site [active] 281309001973 HIT family signature motif; other site 281309001974 catalytic residue [active] 281309001975 RNA polymerase sigma factor; Provisional; Region: PRK12542 281309001976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309001977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309001978 DNA binding residues [nucleotide binding] 281309001979 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 281309001980 Predicted transcriptional regulator [Transcription]; Region: COG2378 281309001981 HTH domain; Region: HTH_11; pfam08279 281309001982 WYL domain; Region: WYL; pfam13280 281309001983 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 281309001984 folate binding site [chemical binding]; other site 281309001985 NADP+ binding site [chemical binding]; other site 281309001986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 281309001987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309001988 dimerization interface [polypeptide binding]; other site 281309001989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309001990 dimer interface [polypeptide binding]; other site 281309001991 phosphorylation site [posttranslational modification] 281309001992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309001993 ATP binding site [chemical binding]; other site 281309001994 Mg2+ binding site [ion binding]; other site 281309001995 G-X-G motif; other site 281309001996 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309001997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309001998 active site 281309001999 phosphorylation site [posttranslational modification] 281309002000 intermolecular recognition site; other site 281309002001 dimerization interface [polypeptide binding]; other site 281309002002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309002003 DNA binding site [nucleotide binding] 281309002004 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 281309002005 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 281309002006 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 281309002007 Sulfate transporter family; Region: Sulfate_transp; pfam00916 281309002008 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 281309002009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 281309002010 Ligand Binding Site [chemical binding]; other site 281309002011 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309002012 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 281309002013 peptide binding site [polypeptide binding]; other site 281309002014 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309002015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002016 dimer interface [polypeptide binding]; other site 281309002017 conserved gate region; other site 281309002018 putative PBP binding loops; other site 281309002019 ABC-ATPase subunit interface; other site 281309002020 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281309002021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002022 dimer interface [polypeptide binding]; other site 281309002023 conserved gate region; other site 281309002024 putative PBP binding loops; other site 281309002025 ABC-ATPase subunit interface; other site 281309002026 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 281309002027 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309002028 Walker A/P-loop; other site 281309002029 ATP binding site [chemical binding]; other site 281309002030 Q-loop/lid; other site 281309002031 ABC transporter signature motif; other site 281309002032 Walker B; other site 281309002033 D-loop; other site 281309002034 H-loop/switch region; other site 281309002035 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309002036 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 281309002037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309002038 Walker A/P-loop; other site 281309002039 ATP binding site [chemical binding]; other site 281309002040 Q-loop/lid; other site 281309002041 ABC transporter signature motif; other site 281309002042 Walker B; other site 281309002043 D-loop; other site 281309002044 H-loop/switch region; other site 281309002045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309002046 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 281309002047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002048 putative substrate translocation pore; other site 281309002049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309002050 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309002051 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 281309002052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002053 putative substrate translocation pore; other site 281309002054 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309002055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309002056 DNA binding site [nucleotide binding] 281309002057 domain linker motif; other site 281309002058 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 281309002059 dimerization interface [polypeptide binding]; other site 281309002060 ligand binding site [chemical binding]; other site 281309002061 sodium binding site [ion binding]; other site 281309002062 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 281309002063 substrate binding site [chemical binding]; other site 281309002064 dimer interface [polypeptide binding]; other site 281309002065 ATP binding site [chemical binding]; other site 281309002066 D-ribose pyranase; Provisional; Region: PRK11797 281309002067 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 281309002068 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281309002069 Walker A/P-loop; other site 281309002070 ATP binding site [chemical binding]; other site 281309002071 Q-loop/lid; other site 281309002072 ABC transporter signature motif; other site 281309002073 Walker B; other site 281309002074 D-loop; other site 281309002075 H-loop/switch region; other site 281309002076 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281309002077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281309002078 TM-ABC transporter signature motif; other site 281309002079 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 281309002080 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 281309002081 ligand binding site [chemical binding]; other site 281309002082 dimerization interface [polypeptide binding]; other site 281309002083 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 281309002084 active site 281309002085 intersubunit interactions; other site 281309002086 catalytic residue [active] 281309002087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 281309002088 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 281309002089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309002091 putative substrate translocation pore; other site 281309002092 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 281309002093 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 281309002094 putative NAD(P) binding site [chemical binding]; other site 281309002095 catalytic Zn binding site [ion binding]; other site 281309002096 Ion channel; Region: Ion_trans_2; pfam07885 281309002097 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 281309002098 Zn binding site [ion binding]; other site 281309002099 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 281309002100 putative catalytic site [active] 281309002101 metal binding site A [ion binding]; metal-binding site 281309002102 phosphate binding site [ion binding]; other site 281309002103 metal binding site C [ion binding]; metal-binding site 281309002104 metal binding site B [ion binding]; metal-binding site 281309002105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 281309002106 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 281309002107 dimer interface [polypeptide binding]; other site 281309002108 active site 281309002109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281309002110 substrate binding site [chemical binding]; other site 281309002111 catalytic residue [active] 281309002112 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 281309002113 FAD binding domain; Region: FAD_binding_4; pfam01565 281309002114 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 281309002115 VanZ like family; Region: VanZ; pfam04892 281309002116 RDD family; Region: RDD; pfam06271 281309002117 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 281309002118 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309002119 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309002120 dimer interface [polypeptide binding]; other site 281309002121 putative CheW interface [polypeptide binding]; other site 281309002122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 281309002123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 281309002124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309002125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309002126 non-specific DNA binding site [nucleotide binding]; other site 281309002127 salt bridge; other site 281309002128 sequence-specific DNA binding site [nucleotide binding]; other site 281309002129 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 281309002130 active site 281309002131 catalytic site [active] 281309002132 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 281309002133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002134 putative substrate translocation pore; other site 281309002135 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 281309002136 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 281309002137 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 281309002138 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 281309002139 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 281309002140 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 281309002141 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309002142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309002143 non-specific DNA binding site [nucleotide binding]; other site 281309002144 salt bridge; other site 281309002145 sequence-specific DNA binding site [nucleotide binding]; other site 281309002146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309002147 Coenzyme A binding pocket [chemical binding]; other site 281309002148 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 281309002149 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 281309002150 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 281309002151 TrkA-N domain; Region: TrkA_N; pfam02254 281309002152 TrkA-C domain; Region: TrkA_C; pfam02080 281309002153 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 281309002154 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 281309002155 Subunit I/III interface [polypeptide binding]; other site 281309002156 Subunit III/IV interface [polypeptide binding]; other site 281309002157 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 281309002158 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 281309002159 D-pathway; other site 281309002160 Putative ubiquinol binding site [chemical binding]; other site 281309002161 Low-spin heme (heme b) binding site [chemical binding]; other site 281309002162 Putative water exit pathway; other site 281309002163 Binuclear center (heme o3/CuB) [ion binding]; other site 281309002164 K-pathway; other site 281309002165 Putative proton exit pathway; other site 281309002166 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 281309002167 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 281309002168 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 281309002169 S-methylmethionine transporter; Provisional; Region: PRK11387 281309002170 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 281309002171 putative active site [active] 281309002172 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309002173 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 281309002174 metal binding site [ion binding]; metal-binding site 281309002175 dimer interface [polypeptide binding]; other site 281309002176 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 281309002177 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 281309002178 Na binding site [ion binding]; other site 281309002179 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309002180 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 281309002181 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 281309002182 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 281309002183 Nucleoside recognition; Region: Gate; pfam07670 281309002184 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 281309002185 Nucleoside recognition; Region: Gate; pfam07670 281309002186 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 281309002187 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 281309002188 G1 box; other site 281309002189 GTP/Mg2+ binding site [chemical binding]; other site 281309002190 Switch I region; other site 281309002191 G2 box; other site 281309002192 G3 box; other site 281309002193 Switch II region; other site 281309002194 G4 box; other site 281309002195 G5 box; other site 281309002196 FeoA domain; Region: FeoA; pfam04023 281309002197 phosphate binding protein; Region: ptsS_2; TIGR02136 281309002198 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 281309002199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002200 dimer interface [polypeptide binding]; other site 281309002201 conserved gate region; other site 281309002202 putative PBP binding loops; other site 281309002203 ABC-ATPase subunit interface; other site 281309002204 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 281309002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002206 dimer interface [polypeptide binding]; other site 281309002207 conserved gate region; other site 281309002208 putative PBP binding loops; other site 281309002209 ABC-ATPase subunit interface; other site 281309002210 AAA domain; Region: AAA_17; cl19128 281309002211 AAA domain; Region: AAA_33; pfam13671 281309002212 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 281309002213 MMPL family; Region: MMPL; cl14618 281309002214 MMPL family; Region: MMPL; cl14618 281309002215 FOG: CBS domain [General function prediction only]; Region: COG0517 281309002216 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 281309002217 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 281309002218 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 281309002219 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309002220 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309002221 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309002222 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309002223 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309002224 Putative transcription activator [Transcription]; Region: TenA; COG0819 281309002225 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 281309002226 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 281309002227 Walker A/P-loop; other site 281309002228 ATP binding site [chemical binding]; other site 281309002229 Q-loop/lid; other site 281309002230 ABC transporter signature motif; other site 281309002231 Walker B; other site 281309002232 D-loop; other site 281309002233 H-loop/switch region; other site 281309002234 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 281309002235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002236 dimer interface [polypeptide binding]; other site 281309002237 conserved gate region; other site 281309002238 putative PBP binding loops; other site 281309002239 ABC-ATPase subunit interface; other site 281309002240 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 281309002241 NMT1/THI5 like; Region: NMT1; pfam09084 281309002242 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 281309002243 thiamine phosphate binding site [chemical binding]; other site 281309002244 active site 281309002245 pyrophosphate binding site [ion binding]; other site 281309002246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309002247 FAD dependent oxidoreductase; Region: DAO; pfam01266 281309002248 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 281309002249 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 281309002250 thiS-thiF/thiG interaction site; other site 281309002251 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 281309002252 ThiS interaction site; other site 281309002253 putative active site [active] 281309002254 tetramer interface [polypeptide binding]; other site 281309002255 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 281309002256 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 281309002257 ATP binding site [chemical binding]; other site 281309002258 substrate interface [chemical binding]; other site 281309002259 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 281309002260 dimer interface [polypeptide binding]; other site 281309002261 substrate binding site [chemical binding]; other site 281309002262 ATP binding site [chemical binding]; other site 281309002263 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 281309002264 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 281309002265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309002266 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 281309002267 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 281309002268 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 281309002269 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 281309002270 Ligand Binding Site [chemical binding]; other site 281309002271 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 281309002272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002273 putative substrate translocation pore; other site 281309002274 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309002275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309002276 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 281309002277 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 281309002278 active site 281309002279 nucleophile elbow; other site 281309002280 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309002281 FtsX-like permease family; Region: FtsX; pfam02687 281309002282 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309002283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309002284 FtsX-like permease family; Region: FtsX; pfam02687 281309002285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309002286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309002287 Walker A/P-loop; other site 281309002288 ATP binding site [chemical binding]; other site 281309002289 Q-loop/lid; other site 281309002290 ABC transporter signature motif; other site 281309002291 Walker B; other site 281309002292 D-loop; other site 281309002293 H-loop/switch region; other site 281309002294 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281309002295 TM-ABC transporter signature motif; other site 281309002296 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281309002297 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 281309002298 Walker A/P-loop; other site 281309002299 ATP binding site [chemical binding]; other site 281309002300 Q-loop/lid; other site 281309002301 ABC transporter signature motif; other site 281309002302 Walker B; other site 281309002303 D-loop; other site 281309002304 H-loop/switch region; other site 281309002305 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281309002306 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 281309002307 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 281309002308 putative ligand binding site [chemical binding]; other site 281309002309 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 281309002310 oxidoreductase; Provisional; Region: PRK06128 281309002311 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 281309002312 NAD binding site [chemical binding]; other site 281309002313 metal binding site [ion binding]; metal-binding site 281309002314 active site 281309002315 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 281309002316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 281309002317 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 281309002318 putative substrate binding site [chemical binding]; other site 281309002319 putative ATP binding site [chemical binding]; other site 281309002320 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 281309002321 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 281309002322 substrate binding [chemical binding]; other site 281309002323 active site 281309002324 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 281309002325 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 281309002326 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309002327 active site turn [active] 281309002328 phosphorylation site [posttranslational modification] 281309002329 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309002330 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309002331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309002332 DNA binding site [nucleotide binding] 281309002333 domain linker motif; other site 281309002334 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 281309002335 dimerization interface [polypeptide binding]; other site 281309002336 ligand binding site [chemical binding]; other site 281309002337 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 281309002338 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281309002339 catalytic residues [active] 281309002340 putative disulfide oxidoreductase; Provisional; Region: PRK03113 281309002341 YhdB-like protein; Region: YhdB; pfam14148 281309002342 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 281309002343 Spore germination protein; Region: Spore_permease; cl17796 281309002344 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 281309002345 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309002346 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 281309002347 putative FMN binding site [chemical binding]; other site 281309002348 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 281309002349 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 281309002350 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 281309002351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309002352 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 281309002353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309002354 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 281309002355 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 281309002356 active site residue [active] 281309002357 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 281309002358 putative homodimer interface [polypeptide binding]; other site 281309002359 putative homotetramer interface [polypeptide binding]; other site 281309002360 putative metal binding site [ion binding]; other site 281309002361 putative homodimer-homodimer interface [polypeptide binding]; other site 281309002362 putative allosteric switch controlling residues; other site 281309002363 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 281309002364 CPxP motif; other site 281309002365 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281309002366 active site residue [active] 281309002367 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 281309002368 active site residue [active] 281309002369 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 281309002370 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 281309002371 CPxP motif; other site 281309002372 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281309002373 active site residue [active] 281309002374 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281309002375 active site residue [active] 281309002376 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 281309002377 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 281309002378 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 281309002379 Cation transport protein; Region: TrkH; cl17365 281309002380 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 281309002381 Cation transport protein; Region: TrkH; cl17365 281309002382 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 281309002383 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 281309002384 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 281309002385 PhoU domain; Region: PhoU; pfam01895 281309002386 PhoU domain; Region: PhoU; pfam01895 281309002387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309002389 putative substrate translocation pore; other site 281309002390 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 281309002391 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 281309002392 HTH domain; Region: HTH_11; pfam08279 281309002393 Mga helix-turn-helix domain; Region: Mga; pfam05043 281309002394 PRD domain; Region: PRD; pfam00874 281309002395 PRD domain; Region: PRD; pfam00874 281309002396 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 281309002397 active site 281309002398 P-loop; other site 281309002399 phosphorylation site [posttranslational modification] 281309002400 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 281309002401 active site 281309002402 phosphorylation site [posttranslational modification] 281309002403 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 281309002404 active site 281309002405 methionine cluster; other site 281309002406 phosphorylation site [posttranslational modification] 281309002407 metal binding site [ion binding]; metal-binding site 281309002408 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 281309002409 active site 281309002410 P-loop; other site 281309002411 phosphorylation site [posttranslational modification] 281309002412 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 281309002413 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 281309002414 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309002415 Bacterial SH3 domain homologues; Region: SH3b; smart00287 281309002416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 281309002417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309002418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309002419 FtsX-like permease family; Region: FtsX; pfam02687 281309002420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309002421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309002422 Walker A/P-loop; other site 281309002423 ATP binding site [chemical binding]; other site 281309002424 Q-loop/lid; other site 281309002425 ABC transporter signature motif; other site 281309002426 Walker B; other site 281309002427 D-loop; other site 281309002428 H-loop/switch region; other site 281309002429 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 281309002430 HlyD family secretion protein; Region: HlyD_3; pfam13437 281309002431 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 281309002432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002433 dimer interface [polypeptide binding]; other site 281309002434 conserved gate region; other site 281309002435 putative PBP binding loops; other site 281309002436 ABC-ATPase subunit interface; other site 281309002437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309002438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002439 dimer interface [polypeptide binding]; other site 281309002440 conserved gate region; other site 281309002441 ABC-ATPase subunit interface; other site 281309002442 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 281309002443 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 281309002444 dimanganese center [ion binding]; other site 281309002445 CotJB protein; Region: CotJB; pfam12652 281309002446 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 281309002447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 281309002448 active site 281309002449 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 281309002450 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 281309002451 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 281309002452 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 281309002453 putative DNA binding site [nucleotide binding]; other site 281309002454 putative homodimer interface [polypeptide binding]; other site 281309002455 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 281309002456 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309002457 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 281309002458 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 281309002459 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 281309002460 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 281309002461 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 281309002462 active site 281309002463 metal binding site [ion binding]; metal-binding site 281309002464 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 281309002465 Interdomain contacts; other site 281309002466 Cytokine receptor motif; other site 281309002467 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 281309002468 amino acid transporter; Region: 2A0306; TIGR00909 281309002469 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309002470 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 281309002471 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 281309002472 DNA topoisomerase VI, subunit B [DNA replication, recombination, and repair]; Region: COG1389 281309002473 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 281309002474 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 281309002475 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 281309002476 putative active site [active] 281309002477 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 281309002478 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 281309002479 putative active site [active] 281309002480 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309002481 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 281309002482 active site turn [active] 281309002483 phosphorylation site [posttranslational modification] 281309002484 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309002485 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 281309002486 DoxX; Region: DoxX; pfam07681 281309002487 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 281309002488 hypothetical protein; Provisional; Region: PRK06770 281309002489 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309002490 EamA-like transporter family; Region: EamA; pfam00892 281309002491 EamA-like transporter family; Region: EamA; pfam00892 281309002492 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 281309002493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309002494 putative DNA binding site [nucleotide binding]; other site 281309002495 putative Zn2+ binding site [ion binding]; other site 281309002496 AsnC family; Region: AsnC_trans_reg; pfam01037 281309002497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309002498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309002499 Coenzyme A binding pocket [chemical binding]; other site 281309002500 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 281309002501 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 281309002502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309002503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309002504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309002506 putative substrate translocation pore; other site 281309002507 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309002508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309002509 putative DNA binding site [nucleotide binding]; other site 281309002510 putative Zn2+ binding site [ion binding]; other site 281309002511 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 281309002512 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 281309002513 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 281309002514 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 281309002515 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 281309002516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002518 putative substrate translocation pore; other site 281309002519 intracellular protease, PfpI family; Region: PfpI; TIGR01382 281309002520 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 281309002521 proposed catalytic triad [active] 281309002522 conserved cys residue [active] 281309002523 hydroperoxidase II; Provisional; Region: katE; PRK11249 281309002524 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 281309002525 tetramer interface [polypeptide binding]; other site 281309002526 heme binding pocket [chemical binding]; other site 281309002527 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 281309002528 conserved cys residue [active] 281309002529 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 281309002530 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 281309002531 Spore germination protein; Region: Spore_permease; cl17796 281309002532 glutamate racemase; Provisional; Region: PRK00865 281309002533 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 281309002534 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 281309002535 tetrameric interface [polypeptide binding]; other site 281309002536 activator binding site; other site 281309002537 NADP binding site [chemical binding]; other site 281309002538 substrate binding site [chemical binding]; other site 281309002539 catalytic residues [active] 281309002540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309002541 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 281309002542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309002543 Walker A/P-loop; other site 281309002544 ATP binding site [chemical binding]; other site 281309002545 Q-loop/lid; other site 281309002546 ABC transporter signature motif; other site 281309002547 Walker B; other site 281309002548 D-loop; other site 281309002549 H-loop/switch region; other site 281309002550 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309002551 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309002552 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 281309002553 Walker A/P-loop; other site 281309002554 ATP binding site [chemical binding]; other site 281309002555 Q-loop/lid; other site 281309002556 ABC transporter signature motif; other site 281309002557 Walker B; other site 281309002558 D-loop; other site 281309002559 H-loop/switch region; other site 281309002560 cystine transporter subunit; Provisional; Region: PRK11260 281309002561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 281309002562 substrate binding pocket [chemical binding]; other site 281309002563 membrane-bound complex binding site; other site 281309002564 hinge residues; other site 281309002565 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 281309002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002567 dimer interface [polypeptide binding]; other site 281309002568 conserved gate region; other site 281309002569 putative PBP binding loops; other site 281309002570 ABC-ATPase subunit interface; other site 281309002571 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 281309002572 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 281309002573 Walker A/P-loop; other site 281309002574 ATP binding site [chemical binding]; other site 281309002575 Q-loop/lid; other site 281309002576 ABC transporter signature motif; other site 281309002577 Walker B; other site 281309002578 D-loop; other site 281309002579 H-loop/switch region; other site 281309002580 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309002581 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 281309002582 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 281309002583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 281309002584 Protein of unknown function (DUF445); Region: DUF445; pfam04286 281309002585 hypothetical protein; Provisional; Region: PRK13676 281309002586 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 281309002587 acetolactate synthase; Reviewed; Region: PRK08617 281309002588 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 281309002589 PYR/PP interface [polypeptide binding]; other site 281309002590 dimer interface [polypeptide binding]; other site 281309002591 TPP binding site [chemical binding]; other site 281309002592 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281309002593 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 281309002594 TPP-binding site [chemical binding]; other site 281309002595 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 281309002596 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 281309002597 active site 281309002598 DNA binding site [nucleotide binding] 281309002599 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 281309002600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309002601 active site 281309002602 motif I; other site 281309002603 motif II; other site 281309002604 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309002605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309002606 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309002607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309002608 Transposase domain (DUF772); Region: DUF772; pfam05598 281309002609 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309002610 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 281309002611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309002612 FeS/SAM binding site; other site 281309002613 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 281309002614 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 281309002615 acyl-activating enzyme (AAE) consensus motif; other site 281309002616 putative AMP binding site [chemical binding]; other site 281309002617 putative active site [active] 281309002618 putative CoA binding site [chemical binding]; other site 281309002619 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 281309002620 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 281309002621 Sulfate transporter family; Region: Sulfate_transp; cl19250 281309002622 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 281309002623 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 281309002624 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 281309002625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309002626 nucleotide binding region [chemical binding]; other site 281309002627 ATP-binding site [chemical binding]; other site 281309002628 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 281309002629 stage V sporulation protein B; Region: spore_V_B; TIGR02900 281309002630 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 281309002631 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 281309002632 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 281309002633 S-layer homology domain; Region: SLH; pfam00395 281309002634 S-layer homology domain; Region: SLH; pfam00395 281309002635 S-layer homology domain; Region: SLH; pfam00395 281309002636 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 281309002637 S-layer homology domain; Region: SLH; pfam00395 281309002638 S-layer homology domain; Region: SLH; pfam00395 281309002639 S-layer homology domain; Region: SLH; pfam00395 281309002640 enoyl-CoA hydratase; Provisional; Region: PRK07659 281309002641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309002642 substrate binding site [chemical binding]; other site 281309002643 oxyanion hole (OAH) forming residues; other site 281309002644 trimer interface [polypeptide binding]; other site 281309002645 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 281309002646 metal binding site [ion binding]; metal-binding site 281309002647 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 281309002648 putative oligomer interface [polypeptide binding]; other site 281309002649 putative active site [active] 281309002650 metal binding site [ion binding]; metal-binding site 281309002651 S-layer homology domain; Region: SLH; pfam00395 281309002652 S-layer homology domain; Region: SLH; pfam00395 281309002653 S-layer homology domain; Region: SLH; pfam00395 281309002654 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309002655 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 281309002656 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 281309002657 active site 281309002658 metal binding site [ion binding]; metal-binding site 281309002659 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 281309002660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309002661 S-adenosylmethionine binding site [chemical binding]; other site 281309002662 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 281309002663 proline racemase; Provisional; Region: PRK13969 281309002664 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 281309002665 ornithine cyclodeaminase; Validated; Region: PRK08618 281309002666 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 281309002667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 281309002668 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 281309002669 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 281309002670 LXG domain of WXG superfamily; Region: LXG; pfam04740 281309002671 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 281309002672 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 281309002673 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309002674 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 281309002675 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309002676 Syd protein (SUKH-2); Region: Syd; cl06405 281309002677 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 281309002678 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 281309002679 S-layer homology domain; Region: SLH; pfam00395 281309002680 S-layer homology domain; Region: SLH; pfam00395 281309002681 S-layer homology domain; Region: SLH; pfam00395 281309002682 Yip1 domain; Region: Yip1; pfam04893 281309002683 hypothetical protein; Validated; Region: PRK09718 281309002684 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 281309002685 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 281309002686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281309002687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002688 dimer interface [polypeptide binding]; other site 281309002689 conserved gate region; other site 281309002690 putative PBP binding loops; other site 281309002691 ABC-ATPase subunit interface; other site 281309002692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309002693 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 281309002694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309002695 dimer interface [polypeptide binding]; other site 281309002696 conserved gate region; other site 281309002697 putative PBP binding loops; other site 281309002698 ABC-ATPase subunit interface; other site 281309002699 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 281309002700 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309002701 Walker A/P-loop; other site 281309002702 ATP binding site [chemical binding]; other site 281309002703 Q-loop/lid; other site 281309002704 ABC transporter signature motif; other site 281309002705 Walker B; other site 281309002706 D-loop; other site 281309002707 H-loop/switch region; other site 281309002708 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309002709 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 281309002710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309002711 Walker A/P-loop; other site 281309002712 ATP binding site [chemical binding]; other site 281309002713 Q-loop/lid; other site 281309002714 ABC transporter signature motif; other site 281309002715 Walker B; other site 281309002716 D-loop; other site 281309002717 H-loop/switch region; other site 281309002718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309002719 Predicted transcriptional regulator [Transcription]; Region: COG2378 281309002720 WYL domain; Region: WYL; pfam13280 281309002721 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 281309002722 G1 box; other site 281309002723 GTP/Mg2+ binding site [chemical binding]; other site 281309002724 G2 box; other site 281309002725 Switch I region; other site 281309002726 G3 box; other site 281309002727 Switch II region; other site 281309002728 G4 box; other site 281309002729 G5 box; other site 281309002730 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 281309002731 G1 box; other site 281309002732 GTP/Mg2+ binding site [chemical binding]; other site 281309002733 G2 box; other site 281309002734 Switch I region; other site 281309002735 G3 box; other site 281309002736 Switch II region; other site 281309002737 G4 box; other site 281309002738 G5 box; other site 281309002739 Domain of unknown function DUF87; Region: DUF87; cl19135 281309002740 AAA-like domain; Region: AAA_10; pfam12846 281309002741 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 281309002742 SMI1-KNR4 cell-wall; Region: SUKH_6; pfam14568 281309002743 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 281309002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309002745 putative substrate translocation pore; other site 281309002746 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 281309002747 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 281309002748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309002749 putative active site [active] 281309002750 heme pocket [chemical binding]; other site 281309002751 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 281309002752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309002753 ATP binding site [chemical binding]; other site 281309002754 Mg2+ binding site [ion binding]; other site 281309002755 G-X-G motif; other site 281309002756 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 281309002757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309002758 active site 281309002759 phosphorylation site [posttranslational modification] 281309002760 intermolecular recognition site; other site 281309002761 dimerization interface [polypeptide binding]; other site 281309002762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 281309002763 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 281309002764 cofactor binding site; other site 281309002765 DNA binding site [nucleotide binding] 281309002766 substrate interaction site [chemical binding]; other site 281309002767 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 281309002768 cofactor binding site; other site 281309002769 DNA binding site [nucleotide binding] 281309002770 substrate interaction site [chemical binding]; other site 281309002771 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 281309002772 AAA ATPase domain; Region: AAA_15; pfam13175 281309002773 AAA domain; Region: AAA_23; pfam13476 281309002774 Walker A/P-loop; other site 281309002775 ATP binding site [chemical binding]; other site 281309002776 AAA domain; Region: AAA_21; pfam13304 281309002777 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309002778 Protein of unknown function DUF262; Region: DUF262; pfam03235 281309002779 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 281309002780 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 281309002781 metal binding site [ion binding]; metal-binding site 281309002782 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 281309002783 replicative DNA helicase; Provisional; Region: PRK06749 281309002784 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 281309002785 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 281309002786 Walker A motif; other site 281309002787 ATP binding site [chemical binding]; other site 281309002788 Walker B motif; other site 281309002789 DNA binding loops [nucleotide binding] 281309002790 Predicted transcriptional regulators [Transcription]; Region: COG1378 281309002791 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 281309002792 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 281309002793 C-terminal domain interface [polypeptide binding]; other site 281309002794 sugar binding site [chemical binding]; other site 281309002795 hypothetical protein; Provisional; Region: PRK10621 281309002796 Predicted permease; Region: DUF318; cl17795 281309002797 Predicted permease; Region: DUF318; cl17795 281309002798 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 281309002799 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309002800 hypothetical protein; Provisional; Region: PRK14082 281309002801 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 281309002802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309002803 DNA binding residues [nucleotide binding] 281309002804 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 281309002805 catalytic residues [active] 281309002806 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 281309002807 Subtilase family; Region: Peptidase_S8; pfam00082 281309002808 active site 281309002809 catalytic residues [active] 281309002810 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 281309002811 primary metal binding site; other site 281309002812 catalytic residues [active] 281309002813 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 281309002814 catalytic residues [active] 281309002815 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 281309002816 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 281309002817 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 281309002818 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 281309002819 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 281309002820 CGNR zinc finger; Region: zf-CGNR; pfam11706 281309002821 HPP family; Region: HPP; pfam04982 281309002822 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 281309002823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309002824 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 281309002825 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 281309002826 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002827 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002828 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002829 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002830 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002831 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002832 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309002833 YmzC-like protein; Region: YmzC; pfam14157 281309002834 transcriptional antiterminator BglG; Provisional; Region: PRK09772 281309002835 CAT RNA binding domain; Region: CAT_RBD; smart01061 281309002836 PRD domain; Region: PRD; pfam00874 281309002837 PRD domain; Region: PRD; pfam00874 281309002838 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 281309002839 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309002840 active site turn [active] 281309002841 phosphorylation site [posttranslational modification] 281309002842 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309002843 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 281309002844 HPr interaction site; other site 281309002845 glycerol kinase (GK) interaction site [polypeptide binding]; other site 281309002846 active site 281309002847 phosphorylation site [posttranslational modification] 281309002848 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 281309002849 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 281309002850 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309002851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309002852 putative DNA binding site [nucleotide binding]; other site 281309002853 putative Zn2+ binding site [ion binding]; other site 281309002854 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 281309002855 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 281309002856 ATP synthase I chain; Region: ATP_synt_I; pfam03899 281309002857 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309002858 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309002859 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 281309002860 VanZ like family; Region: VanZ; pfam04892 281309002861 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 281309002862 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 281309002863 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 281309002864 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 281309002865 dihydroxyacetone kinase; Provisional; Region: PRK14479 281309002866 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 281309002867 DAK2 domain; Region: Dak2; pfam02734 281309002868 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309002869 CAAX protease self-immunity; Region: Abi; pfam02517 281309002870 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309002871 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309002872 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 281309002873 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 281309002874 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309002875 Zn2+ binding site [ion binding]; other site 281309002876 Mg2+ binding site [ion binding]; other site 281309002877 hypothetical protein; Provisional; Region: PRK12361 281309002878 S-layer homology domain; Region: SLH; pfam00395 281309002879 S-layer homology domain; Region: SLH; pfam00395 281309002880 S-layer homology domain; Region: SLH; pfam00395 281309002881 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 281309002882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309002883 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309002884 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 281309002885 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 281309002886 S-layer homology domain; Region: SLH; pfam00395 281309002887 S-layer homology domain; Region: SLH; pfam00395 281309002888 S-layer homology domain; Region: SLH; pfam00395 281309002889 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 281309002890 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 281309002891 Heat induced stress protein YflT; Region: YflT; pfam11181 281309002892 CsbD-like; Region: CsbD; pfam05532 281309002893 Predicted membrane protein [Function unknown]; Region: COG2261 281309002894 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 281309002895 anti sigma factor interaction site; other site 281309002896 regulatory phosphorylation site [posttranslational modification]; other site 281309002897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309002898 ATP binding site [chemical binding]; other site 281309002899 Mg2+ binding site [ion binding]; other site 281309002900 G-X-G motif; other site 281309002901 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 281309002902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309002903 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281309002904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309002905 DNA binding residues [nucleotide binding] 281309002906 Ferritin-like domain; Region: Ferritin; pfam00210 281309002907 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 281309002908 dinuclear metal binding motif [ion binding]; other site 281309002909 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309002910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309002911 active site 281309002912 phosphorylation site [posttranslational modification] 281309002913 intermolecular recognition site; other site 281309002914 dimerization interface [polypeptide binding]; other site 281309002915 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 281309002916 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 281309002917 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 281309002918 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 281309002919 CHASE3 domain; Region: CHASE3; pfam05227 281309002920 HAMP domain; Region: HAMP; pfam00672 281309002921 GAF domain; Region: GAF_2; pfam13185 281309002922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309002923 Borna disease virus P24 protein; Region: BDV_P24; pfam06595 281309002924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309002925 dimer interface [polypeptide binding]; other site 281309002926 phosphorylation site [posttranslational modification] 281309002927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309002928 ATP binding site [chemical binding]; other site 281309002929 Mg2+ binding site [ion binding]; other site 281309002930 G-X-G motif; other site 281309002931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309002932 active site 281309002933 phosphorylation site [posttranslational modification] 281309002934 intermolecular recognition site; other site 281309002935 dimerization interface [polypeptide binding]; other site 281309002936 regulatory protein interface [polypeptide binding]; other site 281309002937 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 281309002938 regulatory phosphorylation site [posttranslational modification]; other site 281309002939 Heat induced stress protein YflT; Region: YflT; pfam11181 281309002940 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 281309002941 hypothetical protein; Provisional; Region: PRK12856 281309002942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309002943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309002944 active site 281309002945 phosphorylation site [posttranslational modification] 281309002946 intermolecular recognition site; other site 281309002947 dimerization interface [polypeptide binding]; other site 281309002948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309002949 DNA binding site [nucleotide binding] 281309002950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309002951 HAMP domain; Region: HAMP; pfam00672 281309002952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309002953 dimer interface [polypeptide binding]; other site 281309002954 phosphorylation site [posttranslational modification] 281309002955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309002956 ATP binding site [chemical binding]; other site 281309002957 Mg2+ binding site [ion binding]; other site 281309002958 G-X-G motif; other site 281309002959 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309002960 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 281309002961 Walker A/P-loop; other site 281309002962 ATP binding site [chemical binding]; other site 281309002963 Q-loop/lid; other site 281309002964 ABC transporter signature motif; other site 281309002965 Walker B; other site 281309002966 D-loop; other site 281309002967 H-loop/switch region; other site 281309002968 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281309002969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 281309002970 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309002971 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 281309002972 NADP binding site [chemical binding]; other site 281309002973 dimer interface [polypeptide binding]; other site 281309002974 YhzD-like protein; Region: YhzD; pfam14120 281309002975 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 281309002976 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 281309002977 active site 281309002978 metal binding site [ion binding]; metal-binding site 281309002979 DNA binding site [nucleotide binding] 281309002980 AAA domain; Region: AAA_23; pfam13476 281309002981 AAA domain; Region: AAA_27; pfam13514 281309002982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309002983 Q-loop/lid; other site 281309002984 ABC transporter signature motif; other site 281309002985 Walker B; other site 281309002986 D-loop; other site 281309002987 H-loop/switch region; other site 281309002988 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 281309002989 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 281309002990 generic binding surface I; other site 281309002991 generic binding surface II; other site 281309002992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309002993 Zn2+ binding site [ion binding]; other site 281309002994 Mg2+ binding site [ion binding]; other site 281309002995 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309002996 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 281309002997 Zn binding site [ion binding]; other site 281309002998 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 281309002999 Zn binding site [ion binding]; other site 281309003000 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 281309003001 Zn binding site [ion binding]; other site 281309003002 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 281309003003 Zn binding site [ion binding]; other site 281309003004 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309003005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309003006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309003007 TPR motif; other site 281309003008 binding surface 281309003009 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309003010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309003011 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 281309003012 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 281309003013 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 281309003014 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 281309003015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309003016 non-specific DNA binding site [nucleotide binding]; other site 281309003017 salt bridge; other site 281309003018 sequence-specific DNA binding site [nucleotide binding]; other site 281309003019 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 281309003020 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 281309003021 amphipathic channel; other site 281309003022 Asn-Pro-Ala signature motifs; other site 281309003023 glycerol kinase; Provisional; Region: glpK; PRK00047 281309003024 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 281309003025 N- and C-terminal domain interface [polypeptide binding]; other site 281309003026 active site 281309003027 MgATP binding site [chemical binding]; other site 281309003028 catalytic site [active] 281309003029 metal binding site [ion binding]; metal-binding site 281309003030 glycerol binding site [chemical binding]; other site 281309003031 homotetramer interface [polypeptide binding]; other site 281309003032 homodimer interface [polypeptide binding]; other site 281309003033 FBP binding site [chemical binding]; other site 281309003034 protein IIAGlc interface [polypeptide binding]; other site 281309003035 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 281309003036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309003037 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 281309003038 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 281309003039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309003040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309003041 DNA binding residues [nucleotide binding] 281309003042 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 281309003043 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 281309003044 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309003045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309003046 DoxX-like family; Region: DoxX_2; pfam13564 281309003047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309003048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309003049 putative substrate translocation pore; other site 281309003050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309003051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309003052 putative substrate translocation pore; other site 281309003053 Putative integral membrane protein DUF46; Region: DUF46; cl17511 281309003054 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 281309003055 Part of AAA domain; Region: AAA_19; pfam13245 281309003056 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 281309003057 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 281309003058 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 281309003059 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 281309003060 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 281309003061 transcriptional regulator Hpr; Provisional; Region: PRK13777 281309003062 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309003063 YtxH-like protein; Region: YtxH; cl02079 281309003064 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 281309003065 HIT family signature motif; other site 281309003066 catalytic residue [active] 281309003067 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281309003068 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309003069 Walker A/P-loop; other site 281309003070 ATP binding site [chemical binding]; other site 281309003071 Q-loop/lid; other site 281309003072 ABC transporter signature motif; other site 281309003073 Walker B; other site 281309003074 D-loop; other site 281309003075 H-loop/switch region; other site 281309003076 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 281309003077 EcsC protein family; Region: EcsC; pfam12787 281309003078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309003079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309003080 Bacterial PH domain; Region: bPH_2; cl01348 281309003081 Predicted membrane protein [Function unknown]; Region: COG3428 281309003082 Bacterial PH domain; Region: bPH_2; pfam03703 281309003083 Bacterial PH domain; Region: bPH_2; pfam03703 281309003084 Bacterial PH domain; Region: bPH_2; pfam03703 281309003085 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 281309003086 MAEBL; Provisional; Region: PTZ00121 281309003087 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 281309003088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 281309003089 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 281309003090 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 281309003091 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309003092 DNA binding residues [nucleotide binding] 281309003093 drug binding residues [chemical binding]; other site 281309003094 dimer interface [polypeptide binding]; other site 281309003095 Bacterial PH domain; Region: bPH_2; cl01348 281309003096 Predicted membrane protein [Function unknown]; Region: COG3428 281309003097 Bacterial PH domain; Region: bPH_2; pfam03703 281309003098 Bacterial PH domain; Region: bPH_2; pfam03703 281309003099 Bacterial PH domain; Region: bPH_2; pfam03703 281309003100 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 281309003101 Transglycosylase; Region: Transgly; pfam00912 281309003102 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281309003103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309003104 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 281309003105 substrate binding site [chemical binding]; other site 281309003106 active site 281309003107 ferrochelatase; Provisional; Region: PRK12435 281309003108 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 281309003109 C-terminal domain interface [polypeptide binding]; other site 281309003110 active site 281309003111 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 281309003112 active site 281309003113 N-terminal domain interface [polypeptide binding]; other site 281309003114 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 281309003115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281309003116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309003117 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 281309003118 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 281309003119 Fn3 associated; Region: Fn3_assoc; pfam13287 281309003120 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 281309003121 generic binding surface II; other site 281309003122 generic binding surface I; other site 281309003123 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 281309003124 putative active site [active] 281309003125 putative catalytic site [active] 281309003126 putative Mg binding site IVb [ion binding]; other site 281309003127 putative phosphate binding site [ion binding]; other site 281309003128 putative DNA binding site [nucleotide binding]; other site 281309003129 putative Mg binding site IVa [ion binding]; other site 281309003130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309003131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309003132 Predicted membrane protein [Function unknown]; Region: COG1511 281309003133 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 281309003134 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 281309003135 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 281309003136 trimer interface [polypeptide binding]; other site 281309003137 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 281309003138 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 281309003139 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 281309003140 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 281309003141 DinB superfamily; Region: DinB_2; pfam12867 281309003142 Predicted transcriptional regulator [Transcription]; Region: COG2378 281309003143 HTH domain; Region: HTH_11; pfam08279 281309003144 WYL domain; Region: WYL; pfam13280 281309003145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309003146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309003147 DNA binding site [nucleotide binding] 281309003148 domain linker motif; other site 281309003149 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 281309003150 putative dimerization interface [polypeptide binding]; other site 281309003151 putative ligand binding site [chemical binding]; other site 281309003152 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 281309003153 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 281309003154 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 281309003155 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 281309003156 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 281309003157 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 281309003158 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 281309003159 acyl-activating enzyme (AAE) consensus motif; other site 281309003160 putative AMP binding site [chemical binding]; other site 281309003161 putative active site [active] 281309003162 putative CoA binding site [chemical binding]; other site 281309003163 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 281309003164 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309003165 heme-binding site [chemical binding]; other site 281309003166 S-layer homology domain; Region: SLH; pfam00395 281309003167 S-layer homology domain; Region: SLH; pfam00395 281309003168 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 281309003169 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 281309003170 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 281309003171 putative active site [active] 281309003172 putative metal binding site [ion binding]; other site 281309003173 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309003174 Zn2+ binding site [ion binding]; other site 281309003175 Mg2+ binding site [ion binding]; other site 281309003176 Putative zinc-finger; Region: zf-HC2; pfam13490 281309003177 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 281309003178 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 281309003179 RNA polymerase sigma factor; Provisional; Region: PRK12541 281309003180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309003181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309003182 DNA binding residues [nucleotide binding] 281309003183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309003184 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 281309003185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309003186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 281309003187 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 281309003188 active site 281309003189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309003190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309003191 dimer interface [polypeptide binding]; other site 281309003192 phosphorylation site [posttranslational modification] 281309003193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309003194 ATP binding site [chemical binding]; other site 281309003195 Mg2+ binding site [ion binding]; other site 281309003196 G-X-G motif; other site 281309003197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309003198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309003199 active site 281309003200 phosphorylation site [posttranslational modification] 281309003201 intermolecular recognition site; other site 281309003202 dimerization interface [polypeptide binding]; other site 281309003203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309003204 DNA binding site [nucleotide binding] 281309003205 CAAX protease self-immunity; Region: Abi; pfam02517 281309003206 Peptidase family M48; Region: Peptidase_M48; pfam01435 281309003207 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309003208 EamA-like transporter family; Region: EamA; pfam00892 281309003209 EamA-like transporter family; Region: EamA; pfam00892 281309003210 S-layer homology domain; Region: SLH; pfam00395 281309003211 S-layer homology domain; Region: SLH; pfam00395 281309003212 S-layer homology domain; Region: SLH; pfam00395 281309003213 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309003214 S-layer homology domain; Region: SLH; pfam00395 281309003215 S-layer homology domain; Region: SLH; pfam00395 281309003216 S-layer homology domain; Region: SLH; pfam00395 281309003217 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 281309003218 active site 281309003219 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 281309003220 tetramer interface [polypeptide binding]; other site 281309003221 active site 281309003222 Mg2+/Mn2+ binding site [ion binding]; other site 281309003223 Phosphotransferase enzyme family; Region: APH; pfam01636 281309003224 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 281309003225 active site 281309003226 substrate binding site [chemical binding]; other site 281309003227 ATP binding site [chemical binding]; other site 281309003228 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281309003229 DNA-binding site [nucleotide binding]; DNA binding site 281309003230 RNA-binding motif; other site 281309003231 ComK protein; Region: ComK; pfam06338 281309003232 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 281309003233 protein binding site [polypeptide binding]; other site 281309003234 Histidine kinase; Region: HisKA_3; pfam07730 281309003235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309003236 ATP binding site [chemical binding]; other site 281309003237 Mg2+ binding site [ion binding]; other site 281309003238 G-X-G motif; other site 281309003239 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309003240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309003241 active site 281309003242 phosphorylation site [posttranslational modification] 281309003243 intermolecular recognition site; other site 281309003244 dimerization interface [polypeptide binding]; other site 281309003245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309003246 DNA binding residues [nucleotide binding] 281309003247 dimerization interface [polypeptide binding]; other site 281309003248 Uncharacterized conserved protein [Function unknown]; Region: COG0398 281309003249 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 281309003250 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281309003251 Catalytic site [active] 281309003252 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 281309003253 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 281309003254 AAA domain; Region: AAA_22; pfam13401 281309003255 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 281309003256 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 281309003257 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 281309003258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309003259 ATP binding site [chemical binding]; other site 281309003260 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 281309003261 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 281309003262 hypothetical protein; Provisional; Region: PRK07758 281309003263 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 281309003264 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 281309003265 Spore germination protein GerPC; Region: GerPC; pfam10737 281309003266 Spore germination GerPB; Region: GerPB; pfam10803 281309003267 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 281309003268 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 281309003269 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 281309003270 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 281309003271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309003272 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309003273 inhibitor-cofactor binding pocket; inhibition site 281309003274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309003275 catalytic residue [active] 281309003276 hypothetical protein; Provisional; Region: PRK13673 281309003277 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 281309003278 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 281309003279 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 281309003280 dimer interface [polypeptide binding]; other site 281309003281 active site 281309003282 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 281309003283 Ligand Binding Site [chemical binding]; other site 281309003284 Molecular Tunnel; other site 281309003285 ferrochelatase; Provisional; Region: PRK12435 281309003286 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 281309003287 C-terminal domain interface [polypeptide binding]; other site 281309003288 active site 281309003289 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 281309003290 active site 281309003291 N-terminal domain interface [polypeptide binding]; other site 281309003292 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 281309003293 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 281309003294 tetramer interface [polypeptide binding]; other site 281309003295 heme binding pocket [chemical binding]; other site 281309003296 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 281309003297 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 281309003298 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 281309003299 active site 281309003300 catalytic site [active] 281309003301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309003302 non-specific DNA binding site [nucleotide binding]; other site 281309003303 salt bridge; other site 281309003304 sequence-specific DNA binding site [nucleotide binding]; other site 281309003305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309003306 binding surface 281309003307 TPR motif; other site 281309003308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309003309 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309003310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309003311 Transposase domain (DUF772); Region: DUF772; pfam05598 281309003312 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309003313 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 281309003314 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 281309003315 S1 domain; Region: S1_2; pfam13509 281309003316 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 281309003317 SurA N-terminal domain; Region: SurA_N_3; cl07813 281309003318 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 281309003319 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309003320 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309003321 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309003322 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309003323 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 281309003324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309003325 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 281309003326 active site 281309003327 motif I; other site 281309003328 motif II; other site 281309003329 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309003330 YjzC-like protein; Region: YjzC; pfam14168 281309003331 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 281309003332 Clp amino terminal domain; Region: Clp_N; pfam02861 281309003333 Clp amino terminal domain; Region: Clp_N; pfam02861 281309003334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309003335 Walker A motif; other site 281309003336 ATP binding site [chemical binding]; other site 281309003337 Walker B motif; other site 281309003338 arginine finger; other site 281309003339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309003340 Walker A motif; other site 281309003341 ATP binding site [chemical binding]; other site 281309003342 Walker B motif; other site 281309003343 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 281309003344 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 281309003345 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 281309003346 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 281309003347 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309003348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309003349 NAD(P) binding site [chemical binding]; other site 281309003350 active site 281309003351 ComZ; Region: ComZ; pfam10815 281309003352 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 281309003353 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 281309003354 dimer interface [polypeptide binding]; other site 281309003355 active site 281309003356 CoA binding pocket [chemical binding]; other site 281309003357 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 281309003358 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 281309003359 dimer interface [polypeptide binding]; other site 281309003360 active site 281309003361 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 281309003362 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 281309003363 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 281309003364 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 281309003365 active site 281309003366 HIGH motif; other site 281309003367 dimer interface [polypeptide binding]; other site 281309003368 KMSKS motif; other site 281309003369 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 281309003370 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309003371 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309003372 peptide binding site [polypeptide binding]; other site 281309003373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281309003374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309003375 dimer interface [polypeptide binding]; other site 281309003376 conserved gate region; other site 281309003377 putative PBP binding loops; other site 281309003378 ABC-ATPase subunit interface; other site 281309003379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309003380 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 281309003381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309003382 dimer interface [polypeptide binding]; other site 281309003383 conserved gate region; other site 281309003384 putative PBP binding loops; other site 281309003385 ABC-ATPase subunit interface; other site 281309003386 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 281309003387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309003388 Walker A/P-loop; other site 281309003389 ATP binding site [chemical binding]; other site 281309003390 Q-loop/lid; other site 281309003391 ABC transporter signature motif; other site 281309003392 Walker B; other site 281309003393 D-loop; other site 281309003394 H-loop/switch region; other site 281309003395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309003396 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 281309003397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309003398 Walker A/P-loop; other site 281309003399 ATP binding site [chemical binding]; other site 281309003400 Q-loop/lid; other site 281309003401 ABC transporter signature motif; other site 281309003402 Walker B; other site 281309003403 D-loop; other site 281309003404 H-loop/switch region; other site 281309003405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309003406 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 281309003407 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 281309003408 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309003409 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309003410 peptide binding site [polypeptide binding]; other site 281309003411 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 281309003412 putative catalytic residues [active] 281309003413 thiol/disulfide switch; other site 281309003414 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 281309003415 adaptor protein; Provisional; Region: PRK02315 281309003416 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 281309003417 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 281309003418 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 281309003419 putative active site [active] 281309003420 catalytic site [active] 281309003421 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 281309003422 putative active site [active] 281309003423 catalytic site [active] 281309003424 Competence protein CoiA-like family; Region: CoiA; cl11541 281309003425 oligoendopeptidase F; Region: pepF; TIGR00181 281309003426 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 281309003427 active site 281309003428 Zn binding site [ion binding]; other site 281309003429 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 281309003430 catalytic residues [active] 281309003431 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 281309003432 apolar tunnel; other site 281309003433 heme binding site [chemical binding]; other site 281309003434 dimerization interface [polypeptide binding]; other site 281309003435 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 281309003436 putative active site [active] 281309003437 putative metal binding residues [ion binding]; other site 281309003438 signature motif; other site 281309003439 putative triphosphate binding site [ion binding]; other site 281309003440 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 281309003441 synthetase active site [active] 281309003442 NTP binding site [chemical binding]; other site 281309003443 metal binding site [ion binding]; metal-binding site 281309003444 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 281309003445 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 281309003446 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 281309003447 active site 281309003448 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 281309003449 trimer interface [polypeptide binding]; other site 281309003450 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 281309003451 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 281309003452 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 281309003453 active site 281309003454 metal binding site [ion binding]; metal-binding site 281309003455 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 281309003456 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309003457 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 281309003458 active site 281309003459 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309003461 S-adenosylmethionine binding site [chemical binding]; other site 281309003462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 281309003463 exosporium leader peptide; Region: exospor_lead; TIGR03720 281309003464 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 281309003465 putative metal binding site; other site 281309003466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309003467 binding surface 281309003468 TPR motif; other site 281309003469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309003470 binding surface 281309003471 TPR motif; other site 281309003472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309003473 S-adenosylmethionine binding site [chemical binding]; other site 281309003474 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 281309003475 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 281309003476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309003477 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 281309003478 active site 281309003479 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 281309003480 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 281309003481 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 281309003482 NAD binding site [chemical binding]; other site 281309003483 substrate binding site [chemical binding]; other site 281309003484 homodimer interface [polypeptide binding]; other site 281309003485 active site 281309003486 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 281309003487 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 281309003488 NADP binding site [chemical binding]; other site 281309003489 active site 281309003490 putative substrate binding site [chemical binding]; other site 281309003491 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 281309003492 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 281309003493 NAD binding site [chemical binding]; other site 281309003494 homotetramer interface [polypeptide binding]; other site 281309003495 homodimer interface [polypeptide binding]; other site 281309003496 substrate binding site [chemical binding]; other site 281309003497 active site 281309003498 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 281309003499 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 281309003500 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 281309003501 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 281309003502 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 281309003503 Part of AAA domain; Region: AAA_19; pfam13245 281309003504 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 281309003505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309003506 Coenzyme A binding pocket [chemical binding]; other site 281309003507 hypothetical protein; Provisional; Region: PRK13679 281309003508 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 281309003509 Putative esterase; Region: Esterase; pfam00756 281309003510 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 281309003511 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309003512 EamA-like transporter family; Region: EamA; pfam00892 281309003513 EamA-like transporter family; Region: EamA; pfam00892 281309003514 Bacterial PH domain; Region: bPH_4; pfam06713 281309003515 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 281309003516 Pectate lyase; Region: Pectate_lyase; pfam03211 281309003517 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 281309003518 Na binding site [ion binding]; other site 281309003519 anthranilate synthase component I; Provisional; Region: PRK13570 281309003520 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 281309003521 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 281309003522 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 281309003523 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 281309003524 glutamine binding [chemical binding]; other site 281309003525 catalytic triad [active] 281309003526 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 281309003527 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 281309003528 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 281309003529 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 281309003530 active site 281309003531 ribulose/triose binding site [chemical binding]; other site 281309003532 phosphate binding site [ion binding]; other site 281309003533 substrate (anthranilate) binding pocket [chemical binding]; other site 281309003534 product (indole) binding pocket [chemical binding]; other site 281309003535 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 281309003536 active site 281309003537 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 281309003538 cysteine synthase; Region: PLN02565 281309003539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309003540 catalytic residue [active] 281309003541 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 281309003542 substrate binding site [chemical binding]; other site 281309003543 active site 281309003544 catalytic residues [active] 281309003545 heterodimer interface [polypeptide binding]; other site 281309003546 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 281309003547 L-lactate permease; Region: Lactate_perm; cl00701 281309003548 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 281309003549 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 281309003550 Double zinc ribbon; Region: DZR; pfam12773 281309003551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309003552 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 281309003553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309003554 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 281309003555 Predicted acetyltransferase [General function prediction only]; Region: COG5628 281309003556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309003557 Coenzyme A binding pocket [chemical binding]; other site 281309003558 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 281309003559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309003560 S-adenosylmethionine binding site [chemical binding]; other site 281309003561 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 281309003562 NADPH bind site [chemical binding]; other site 281309003563 putative FMN binding site [chemical binding]; other site 281309003564 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 281309003565 putative FMN binding site [chemical binding]; other site 281309003566 NADPH bind site [chemical binding]; other site 281309003567 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 281309003568 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 281309003569 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 281309003570 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 281309003571 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 281309003572 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 281309003573 E3 interaction surface; other site 281309003574 lipoyl attachment site [posttranslational modification]; other site 281309003575 e3 binding domain; Region: E3_binding; pfam02817 281309003576 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281309003577 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 281309003578 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 281309003579 TPP-binding site [chemical binding]; other site 281309003580 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 281309003581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309003582 salt bridge; other site 281309003583 non-specific DNA binding site [nucleotide binding]; other site 281309003584 sequence-specific DNA binding site [nucleotide binding]; other site 281309003585 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 281309003586 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 281309003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309003588 S-adenosylmethionine binding site [chemical binding]; other site 281309003589 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309003590 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309003591 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 281309003592 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281309003593 Catalytic site [active] 281309003594 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 281309003595 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 281309003596 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 281309003597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309003598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309003599 non-specific DNA binding site [nucleotide binding]; other site 281309003600 salt bridge; other site 281309003601 sequence-specific DNA binding site [nucleotide binding]; other site 281309003602 Anti-repressor SinI; Region: SinI; pfam08671 281309003603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 281309003604 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 281309003605 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 281309003606 NAD(P) binding site [chemical binding]; other site 281309003607 catalytic residues [active] 281309003608 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 281309003609 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 281309003610 Walker A/P-loop; other site 281309003611 ATP binding site [chemical binding]; other site 281309003612 Q-loop/lid; other site 281309003613 ABC transporter signature motif; other site 281309003614 Walker B; other site 281309003615 D-loop; other site 281309003616 H-loop/switch region; other site 281309003617 TOBE domain; Region: TOBE_2; pfam08402 281309003618 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 281309003619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309003620 dimer interface [polypeptide binding]; other site 281309003621 conserved gate region; other site 281309003622 putative PBP binding loops; other site 281309003623 ABC-ATPase subunit interface; other site 281309003624 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 281309003625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309003626 dimer interface [polypeptide binding]; other site 281309003627 conserved gate region; other site 281309003628 putative PBP binding loops; other site 281309003629 ABC-ATPase subunit interface; other site 281309003630 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 281309003631 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 281309003632 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309003633 active site 281309003634 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 281309003635 MMPL family; Region: MMPL; cl14618 281309003636 MMPL family; Region: MMPL; cl14618 281309003637 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 281309003638 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 281309003639 active site 281309003640 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 281309003641 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 281309003642 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 281309003643 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 281309003644 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 281309003645 Cysteine-rich domain; Region: CCG; pfam02754 281309003646 Cysteine-rich domain; Region: CCG; pfam02754 281309003647 FAD binding domain; Region: FAD_binding_4; pfam01565 281309003648 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 281309003649 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 281309003650 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 281309003651 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 281309003652 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 281309003653 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 281309003654 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309003655 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309003656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309003657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309003658 active site 281309003659 phosphorylation site [posttranslational modification] 281309003660 intermolecular recognition site; other site 281309003661 dimerization interface [polypeptide binding]; other site 281309003662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309003663 DNA binding site [nucleotide binding] 281309003664 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 281309003665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309003666 dimerization interface [polypeptide binding]; other site 281309003667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309003668 dimer interface [polypeptide binding]; other site 281309003669 phosphorylation site [posttranslational modification] 281309003670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309003671 ATP binding site [chemical binding]; other site 281309003672 Mg2+ binding site [ion binding]; other site 281309003673 G-X-G motif; other site 281309003674 Transcriptional regulators [Transcription]; Region: FadR; COG2186 281309003675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309003676 DNA-binding site [nucleotide binding]; DNA binding site 281309003677 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 281309003678 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 281309003679 Cysteine-rich domain; Region: CCG; pfam02754 281309003680 Cysteine-rich domain; Region: CCG; pfam02754 281309003681 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 281309003682 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 281309003683 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 281309003684 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 281309003685 Uncharacterized conserved protein [Function unknown]; Region: COG1556 281309003686 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 281309003687 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 281309003688 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 281309003689 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 281309003690 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 281309003691 Cation transport protein; Region: TrkH; cl17365 281309003692 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 281309003693 Cation transport protein; Region: TrkH; cl17365 281309003694 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309003695 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 281309003696 dimer interaction site [polypeptide binding]; other site 281309003697 substrate-binding tunnel; other site 281309003698 active site 281309003699 catalytic site [active] 281309003700 substrate binding site [chemical binding]; other site 281309003701 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; pfam09602 281309003702 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 281309003703 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309003704 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 281309003705 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 281309003706 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 281309003707 NAD(P) binding site [chemical binding]; other site 281309003708 active site 281309003709 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 281309003710 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 281309003711 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 281309003712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309003713 FAD dependent oxidoreductase; Region: DAO; pfam01266 281309003714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309003715 Cation transport protein; Region: TrkH; cl17365 281309003716 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 281309003717 Cation transport protein; Region: TrkH; pfam02386 281309003718 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 281309003719 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 281309003720 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 281309003721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309003722 Walker A/P-loop; other site 281309003723 ATP binding site [chemical binding]; other site 281309003724 Q-loop/lid; other site 281309003725 ABC transporter signature motif; other site 281309003726 Walker B; other site 281309003727 D-loop; other site 281309003728 H-loop/switch region; other site 281309003729 TOBE domain; Region: TOBE_2; pfam08402 281309003730 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 281309003731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309003732 dimer interface [polypeptide binding]; other site 281309003733 conserved gate region; other site 281309003734 putative PBP binding loops; other site 281309003735 ABC-ATPase subunit interface; other site 281309003736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309003737 dimer interface [polypeptide binding]; other site 281309003738 conserved gate region; other site 281309003739 putative PBP binding loops; other site 281309003740 ABC-ATPase subunit interface; other site 281309003741 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 281309003742 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 281309003743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309003744 motif II; other site 281309003745 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 281309003746 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309003747 catalytic residue [active] 281309003748 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 281309003749 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 281309003750 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 281309003751 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 281309003752 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309003753 heme-binding site [chemical binding]; other site 281309003754 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 281309003755 Leucine rich repeat; Region: LRR_8; pfam13855 281309003756 Leucine-rich repeats; other site 281309003757 Substrate binding site [chemical binding]; other site 281309003758 Leucine rich repeat; Region: LRR_8; pfam13855 281309003759 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309003760 Leucine rich repeat; Region: LRR_8; pfam13855 281309003761 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309003762 Leucine rich repeat; Region: LRR_8; pfam13855 281309003763 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309003764 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 281309003765 S-layer homology domain; Region: SLH; pfam00395 281309003766 S-layer homology domain; Region: SLH; pfam00395 281309003767 S-layer homology domain; Region: SLH; pfam00395 281309003768 hypothetical protein; Validated; Region: PRK06755 281309003769 intersubunit interface [polypeptide binding]; other site 281309003770 active site 281309003771 Zn2+ binding site [ion binding]; other site 281309003772 FOG: CBS domain [General function prediction only]; Region: COG0517 281309003773 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 281309003774 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 281309003775 NodB motif; other site 281309003776 putative active site [active] 281309003777 putative catalytic site [active] 281309003778 Zn binding site [ion binding]; other site 281309003779 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 281309003780 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 281309003781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309003782 dimer interface [polypeptide binding]; other site 281309003783 phosphorylation site [posttranslational modification] 281309003784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309003785 ATP binding site [chemical binding]; other site 281309003786 Mg2+ binding site [ion binding]; other site 281309003787 G-X-G motif; other site 281309003788 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309003789 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309003790 dimerization interface [polypeptide binding]; other site 281309003791 putative DNA binding site [nucleotide binding]; other site 281309003792 putative Zn2+ binding site [ion binding]; other site 281309003793 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 281309003794 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 281309003795 active site 281309003796 Zn binding site [ion binding]; other site 281309003797 DinB superfamily; Region: DinB_2; pfam12867 281309003798 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 281309003799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309003800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309003801 dimer interface [polypeptide binding]; other site 281309003802 phosphorylation site [posttranslational modification] 281309003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309003804 ATP binding site [chemical binding]; other site 281309003805 Mg2+ binding site [ion binding]; other site 281309003806 G-X-G motif; other site 281309003807 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 281309003808 Ligand Binding Site [chemical binding]; other site 281309003809 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 281309003810 active site 281309003811 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 281309003812 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 281309003813 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 281309003814 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 281309003815 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 281309003816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309003817 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309003818 Coenzyme A binding pocket [chemical binding]; other site 281309003819 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 281309003820 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 281309003821 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 281309003822 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 281309003823 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 281309003824 dimer interface [polypeptide binding]; other site 281309003825 putative radical transfer pathway; other site 281309003826 diiron center [ion binding]; other site 281309003827 tyrosyl radical; other site 281309003828 Predicted transcriptional regulators [Transcription]; Region: COG1725 281309003829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309003830 DNA-binding site [nucleotide binding]; DNA binding site 281309003831 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281309003832 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309003833 Walker A/P-loop; other site 281309003834 ATP binding site [chemical binding]; other site 281309003835 Q-loop/lid; other site 281309003836 ABC transporter signature motif; other site 281309003837 Walker B; other site 281309003838 D-loop; other site 281309003839 H-loop/switch region; other site 281309003840 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309003841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309003842 Walker A/P-loop; other site 281309003843 ATP binding site [chemical binding]; other site 281309003844 Q-loop/lid; other site 281309003845 ABC transporter signature motif; other site 281309003846 Walker B; other site 281309003847 D-loop; other site 281309003848 H-loop/switch region; other site 281309003849 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 281309003850 CAAX protease self-immunity; Region: Abi; pfam02517 281309003851 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 281309003852 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 281309003853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 281309003854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309003855 putative DNA binding site [nucleotide binding]; other site 281309003856 putative Zn2+ binding site [ion binding]; other site 281309003857 AsnC family; Region: AsnC_trans_reg; pfam01037 281309003858 Uncharacterized conserved protein [Function unknown]; Region: COG2128 281309003859 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 281309003860 catalytic triad [active] 281309003861 conserved cis-peptide bond; other site 281309003862 SseB protein N-terminal domain; Region: SseB; pfam07179 281309003863 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 281309003864 dimer interface [polypeptide binding]; other site 281309003865 catalytic triad [active] 281309003866 Nitronate monooxygenase; Region: NMO; pfam03060 281309003867 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 281309003868 FMN binding site [chemical binding]; other site 281309003869 substrate binding site [chemical binding]; other site 281309003870 putative catalytic residue [active] 281309003871 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 281309003872 DltD N-terminal region; Region: DltD_N; pfam04915 281309003873 DltD central region; Region: DltD_M; pfam04918 281309003874 DltD C-terminal region; Region: DltD_C; pfam04914 281309003875 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 281309003876 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 281309003877 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 281309003878 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 281309003879 acyl-activating enzyme (AAE) consensus motif; other site 281309003880 AMP binding site [chemical binding]; other site 281309003881 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 281309003882 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309003883 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 281309003884 metal binding site [ion binding]; metal-binding site 281309003885 dimer interface [polypeptide binding]; other site 281309003886 flavodoxin; Provisional; Region: PRK06756 281309003887 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 281309003888 Phosphotransferase enzyme family; Region: APH; pfam01636 281309003889 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309003890 active site 281309003891 substrate binding site [chemical binding]; other site 281309003892 ATP binding site [chemical binding]; other site 281309003893 multidrug efflux protein; Reviewed; Region: PRK01766 281309003894 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 281309003895 cation binding site [ion binding]; other site 281309003896 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 281309003897 Thioredoxin; Region: Thioredoxin_9; pfam14595 281309003898 Regulatory protein YrvL; Region: YrvL; pfam14184 281309003899 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309003900 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309003901 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 281309003902 Cation transport protein; Region: TrkH; cl17365 281309003903 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 281309003904 Cation transport protein; Region: TrkH; pfam02386 281309003905 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 281309003906 hypothetical protein; Provisional; Region: PRK03094 281309003907 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 281309003908 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 281309003909 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 281309003910 homodimer interface [polypeptide binding]; other site 281309003911 substrate-cofactor binding pocket; other site 281309003912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309003913 catalytic residue [active] 281309003914 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 281309003915 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 281309003916 PYR/PP interface [polypeptide binding]; other site 281309003917 dimer interface [polypeptide binding]; other site 281309003918 TPP binding site [chemical binding]; other site 281309003919 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281309003920 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 281309003921 TPP-binding site [chemical binding]; other site 281309003922 dimer interface [polypeptide binding]; other site 281309003923 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 281309003924 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 281309003925 putative valine binding site [chemical binding]; other site 281309003926 dimer interface [polypeptide binding]; other site 281309003927 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 281309003928 ketol-acid reductoisomerase; Provisional; Region: PRK05479 281309003929 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 281309003930 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 281309003931 2-isopropylmalate synthase; Validated; Region: PRK00915 281309003932 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 281309003933 active site 281309003934 catalytic residues [active] 281309003935 metal binding site [ion binding]; metal-binding site 281309003936 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 281309003937 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 281309003938 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 281309003939 substrate binding site [chemical binding]; other site 281309003940 ligand binding site [chemical binding]; other site 281309003941 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 281309003942 substrate binding site [chemical binding]; other site 281309003943 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 281309003944 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 281309003945 dimer interface [polypeptide binding]; other site 281309003946 motif 1; other site 281309003947 active site 281309003948 motif 2; other site 281309003949 motif 3; other site 281309003950 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 281309003951 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 281309003952 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 281309003953 histidinol dehydrogenase; Region: hisD; TIGR00069 281309003954 NAD binding site [chemical binding]; other site 281309003955 dimerization interface [polypeptide binding]; other site 281309003956 product binding site; other site 281309003957 substrate binding site [chemical binding]; other site 281309003958 zinc binding site [ion binding]; other site 281309003959 catalytic residues [active] 281309003960 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 281309003961 putative active site pocket [active] 281309003962 4-fold oligomerization interface [polypeptide binding]; other site 281309003963 metal binding residues [ion binding]; metal-binding site 281309003964 3-fold/trimer interface [polypeptide binding]; other site 281309003965 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 281309003966 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 281309003967 putative active site [active] 281309003968 oxyanion strand; other site 281309003969 catalytic triad [active] 281309003970 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 281309003971 catalytic residues [active] 281309003972 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 281309003973 substrate binding site [chemical binding]; other site 281309003974 glutamase interaction surface [polypeptide binding]; other site 281309003975 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 281309003976 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 281309003977 metal binding site [ion binding]; metal-binding site 281309003978 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 281309003979 dimer interface [polypeptide binding]; other site 281309003980 active site 281309003981 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 281309003982 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 281309003983 putative ligand binding site [chemical binding]; other site 281309003984 putative NAD binding site [chemical binding]; other site 281309003985 catalytic site [active] 281309003986 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 281309003987 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 281309003988 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 281309003989 Sulfatase; Region: Sulfatase; pfam00884 281309003990 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 281309003991 diaminopimelate decarboxylase; Region: lysA; TIGR01048 281309003992 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 281309003993 active site 281309003994 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281309003995 substrate binding site [chemical binding]; other site 281309003996 catalytic residues [active] 281309003997 dimer interface [polypeptide binding]; other site 281309003998 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 281309003999 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 281309004000 Active Sites [active] 281309004001 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 281309004002 ATP-sulfurylase; Region: ATPS; cd00517 281309004003 active site 281309004004 HXXH motif; other site 281309004005 flexible loop; other site 281309004006 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 281309004007 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 281309004008 ligand-binding site [chemical binding]; other site 281309004009 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 281309004010 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 281309004011 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 281309004012 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 281309004013 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 281309004014 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 281309004015 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 281309004016 active site 281309004017 SAM binding site [chemical binding]; other site 281309004018 homodimer interface [polypeptide binding]; other site 281309004019 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 281309004020 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 281309004021 putative active site [active] 281309004022 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 281309004023 putative active site [active] 281309004024 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 281309004025 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 281309004026 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 281309004027 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 281309004028 Na2 binding site [ion binding]; other site 281309004029 putative substrate binding site 1 [chemical binding]; other site 281309004030 Na binding site 1 [ion binding]; other site 281309004031 putative substrate binding site 2 [chemical binding]; other site 281309004032 HTH-like domain; Region: HTH_21; pfam13276 281309004033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 281309004034 Integrase core domain; Region: rve; pfam00665 281309004035 Integrase core domain; Region: rve_2; pfam13333 281309004036 Transposase; Region: HTH_Tnp_1; cl17663 281309004037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309004038 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 281309004039 Protein of unknown function (DUF342); Region: DUF342; cl19219 281309004040 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309004041 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 281309004042 Protein of unknown function (DUF402); Region: DUF402; cl00979 281309004043 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 281309004044 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281309004045 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 281309004046 Uncharacterized conserved protein [Function unknown]; Region: COG2966 281309004047 PspA/IM30 family; Region: PspA_IM30; pfam04012 281309004048 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 281309004049 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 281309004050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309004051 Histidine kinase; Region: HisKA_3; pfam07730 281309004052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004053 ATP binding site [chemical binding]; other site 281309004054 Mg2+ binding site [ion binding]; other site 281309004055 G-X-G motif; other site 281309004056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309004057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309004058 active site 281309004059 phosphorylation site [posttranslational modification] 281309004060 intermolecular recognition site; other site 281309004061 dimerization interface [polypeptide binding]; other site 281309004062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309004063 DNA binding residues [nucleotide binding] 281309004064 dimerization interface [polypeptide binding]; other site 281309004065 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 281309004066 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 281309004067 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309004068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309004069 S-adenosylmethionine binding site [chemical binding]; other site 281309004070 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 281309004071 Peptidase family M50; Region: Peptidase_M50; pfam02163 281309004072 active site 281309004073 putative substrate binding region [chemical binding]; other site 281309004074 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 281309004075 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 281309004076 heme-binding site [chemical binding]; other site 281309004077 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 281309004078 FAD binding pocket [chemical binding]; other site 281309004079 FAD binding motif [chemical binding]; other site 281309004080 phosphate binding motif [ion binding]; other site 281309004081 beta-alpha-beta structure motif; other site 281309004082 NAD binding pocket [chemical binding]; other site 281309004083 Heme binding pocket [chemical binding]; other site 281309004084 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 281309004085 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 281309004086 ligand binding site [chemical binding]; other site 281309004087 flexible hinge region; other site 281309004088 non-specific DNA interactions [nucleotide binding]; other site 281309004089 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 281309004090 DNA binding site [nucleotide binding] 281309004091 sequence specific DNA binding site [nucleotide binding]; other site 281309004092 putative cAMP binding site [chemical binding]; other site 281309004093 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 281309004094 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 281309004095 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 281309004096 TIGR00153 family protein; Region: TIGR00153 281309004097 Transglycosylase; Region: Transgly; pfam00912 281309004098 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281309004099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309004100 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309004101 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309004102 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309004103 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309004104 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309004105 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309004106 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 281309004107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309004108 putative active site [active] 281309004109 heme pocket [chemical binding]; other site 281309004110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309004111 dimer interface [polypeptide binding]; other site 281309004112 phosphorylation site [posttranslational modification] 281309004113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004114 ATP binding site [chemical binding]; other site 281309004115 Mg2+ binding site [ion binding]; other site 281309004116 G-X-G motif; other site 281309004117 Protein of unknown function DUF72; Region: DUF72; pfam01904 281309004118 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 281309004119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281309004120 active site 281309004121 DNA binding site [nucleotide binding] 281309004122 Int/Topo IB signature motif; other site 281309004123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 281309004124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309004125 dimerization interface [polypeptide binding]; other site 281309004126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309004127 dimer interface [polypeptide binding]; other site 281309004128 phosphorylation site [posttranslational modification] 281309004129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004130 ATP binding site [chemical binding]; other site 281309004131 Mg2+ binding site [ion binding]; other site 281309004132 G-X-G motif; other site 281309004133 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 281309004134 Probable transposase; Region: OrfB_IS605; pfam01385 281309004135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309004136 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309004137 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309004138 Predicted integral membrane protein [Function unknown]; Region: COG0392 281309004139 Uncharacterized conserved protein [Function unknown]; Region: COG2898 281309004140 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 281309004141 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 281309004142 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 281309004143 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 281309004144 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 281309004145 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309004146 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309004147 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 281309004148 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 281309004149 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 281309004150 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 281309004151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309004152 RNA binding surface [nucleotide binding]; other site 281309004153 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 281309004154 active site 281309004155 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 281309004156 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 281309004157 catalytic residues [active] 281309004158 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 281309004159 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 281309004160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309004161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309004162 active site 281309004163 phosphorylation site [posttranslational modification] 281309004164 intermolecular recognition site; other site 281309004165 dimerization interface [polypeptide binding]; other site 281309004166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309004167 DNA binding site [nucleotide binding] 281309004168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 281309004169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309004170 dimerization interface [polypeptide binding]; other site 281309004171 PAS domain; Region: PAS; smart00091 281309004172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309004173 dimer interface [polypeptide binding]; other site 281309004174 phosphorylation site [posttranslational modification] 281309004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004176 ATP binding site [chemical binding]; other site 281309004177 Mg2+ binding site [ion binding]; other site 281309004178 G-X-G motif; other site 281309004179 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 281309004180 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309004181 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309004182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309004183 Predicted membrane protein [Function unknown]; Region: COG3601 281309004184 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 281309004185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 281309004186 Helix-turn-helix domain; Region: HTH_40; pfam14493 281309004187 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281309004188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309004189 ATP binding site [chemical binding]; other site 281309004190 putative Mg++ binding site [ion binding]; other site 281309004191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309004192 nucleotide binding region [chemical binding]; other site 281309004193 ATP-binding site [chemical binding]; other site 281309004194 CAAX protease self-immunity; Region: Abi; pfam02517 281309004195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309004196 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 281309004197 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 281309004198 putative active site [active] 281309004199 putative metal binding site [ion binding]; other site 281309004200 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309004201 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 281309004202 DNA binding residues [nucleotide binding] 281309004203 B12 binding domain; Region: B12-binding_2; pfam02607 281309004204 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 281309004205 adaptor protein; Provisional; Region: PRK02899 281309004206 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 281309004207 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 281309004208 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 281309004209 NAD(P) binding site [chemical binding]; other site 281309004210 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 281309004211 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 281309004212 amidase catalytic site [active] 281309004213 Zn binding residues [ion binding]; other site 281309004214 substrate binding site [chemical binding]; other site 281309004215 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 281309004216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 281309004217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309004218 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 281309004219 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 281309004220 active site 281309004221 homotetramer interface [polypeptide binding]; other site 281309004222 homodimer interface [polypeptide binding]; other site 281309004223 cytidylate kinase; Provisional; Region: cmk; PRK00023 281309004224 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 281309004225 AAA domain; Region: AAA_18; pfam13238 281309004226 CMP-binding site; other site 281309004227 The sites determining sugar specificity; other site 281309004228 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 281309004229 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 281309004230 RNA binding site [nucleotide binding]; other site 281309004231 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 281309004232 RNA binding site [nucleotide binding]; other site 281309004233 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 281309004234 RNA binding site [nucleotide binding]; other site 281309004235 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 281309004236 RNA binding site [nucleotide binding]; other site 281309004237 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 281309004238 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 281309004239 homotetramer interface [polypeptide binding]; other site 281309004240 FMN binding site [chemical binding]; other site 281309004241 homodimer contacts [polypeptide binding]; other site 281309004242 putative active site [active] 281309004243 putative substrate binding site [chemical binding]; other site 281309004244 YpzI-like protein; Region: YpzI; pfam14140 281309004245 YIEGIA protein; Region: YIEGIA; pfam14045 281309004246 GTP-binding protein Der; Reviewed; Region: PRK00093 281309004247 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 281309004248 G1 box; other site 281309004249 GTP/Mg2+ binding site [chemical binding]; other site 281309004250 Switch I region; other site 281309004251 G2 box; other site 281309004252 Switch II region; other site 281309004253 G3 box; other site 281309004254 G4 box; other site 281309004255 G5 box; other site 281309004256 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 281309004257 G1 box; other site 281309004258 GTP/Mg2+ binding site [chemical binding]; other site 281309004259 Switch I region; other site 281309004260 G2 box; other site 281309004261 G3 box; other site 281309004262 Switch II region; other site 281309004263 G4 box; other site 281309004264 G5 box; other site 281309004265 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 281309004266 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 281309004267 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 281309004268 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 281309004269 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 281309004270 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 281309004271 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 281309004272 histone-like DNA-binding protein HU; Region: HU; cd13831 281309004273 dimer interface [polypeptide binding]; other site 281309004274 DNA binding site [nucleotide binding] 281309004275 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 281309004276 homodecamer interface [polypeptide binding]; other site 281309004277 active site 281309004278 putative catalytic site residues [active] 281309004279 zinc binding site [ion binding]; other site 281309004280 GTP-CH-I/GFRP interaction surface; other site 281309004281 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 281309004282 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 281309004283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309004284 S-adenosylmethionine binding site [chemical binding]; other site 281309004285 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 281309004286 substrate binding pocket [chemical binding]; other site 281309004287 chain length determination region; other site 281309004288 substrate-Mg2+ binding site; other site 281309004289 catalytic residues [active] 281309004290 aspartate-rich region 1; other site 281309004291 active site lid residues [active] 281309004292 aspartate-rich region 2; other site 281309004293 Nucleoside diphosphate kinase; Region: NDK; pfam00334 281309004294 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 281309004295 active site 281309004296 multimer interface [polypeptide binding]; other site 281309004297 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 281309004298 Tetramer interface [polypeptide binding]; other site 281309004299 active site 281309004300 FMN-binding site [chemical binding]; other site 281309004301 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 281309004302 active site 281309004303 dimer interface [polypeptide binding]; other site 281309004304 metal binding site [ion binding]; metal-binding site 281309004305 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 281309004306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309004307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309004308 homodimer interface [polypeptide binding]; other site 281309004309 catalytic residue [active] 281309004310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309004311 TPR motif; other site 281309004312 binding surface 281309004313 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 281309004314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309004315 binding surface 281309004316 TPR motif; other site 281309004317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309004318 binding surface 281309004319 TPR motif; other site 281309004320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309004321 binding surface 281309004322 TPR motif; other site 281309004323 hypothetical protein; Provisional; Region: PRK03636 281309004324 UPF0302 domain; Region: UPF0302; pfam08864 281309004325 IDEAL domain; Region: IDEAL; pfam08858 281309004326 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 281309004327 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 281309004328 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 281309004329 iron-sulfur cluster [ion binding]; other site 281309004330 [2Fe-2S] cluster binding site [ion binding]; other site 281309004331 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 281309004332 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 281309004333 interchain domain interface [polypeptide binding]; other site 281309004334 intrachain domain interface; other site 281309004335 heme bH binding site [chemical binding]; other site 281309004336 Qi binding site; other site 281309004337 heme bL binding site [chemical binding]; other site 281309004338 Qo binding site; other site 281309004339 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 281309004340 interchain domain interface [polypeptide binding]; other site 281309004341 intrachain domain interface; other site 281309004342 Qi binding site; other site 281309004343 Qo binding site; other site 281309004344 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 281309004345 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 281309004346 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 281309004347 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 281309004348 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 281309004349 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 281309004350 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 281309004351 active site 281309004352 Fe-S cluster binding site [ion binding]; other site 281309004353 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309004354 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309004355 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309004356 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309004357 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 281309004358 homodimer interface [polypeptide binding]; other site 281309004359 metal binding site [ion binding]; metal-binding site 281309004360 dihydrodipicolinate reductase; Provisional; Region: PRK00048 281309004361 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 281309004362 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 281309004363 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 281309004364 active site 281309004365 dimer interfaces [polypeptide binding]; other site 281309004366 catalytic residues [active] 281309004367 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 281309004368 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 281309004369 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 281309004370 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 281309004371 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 281309004372 active site 281309004373 NTP binding site [chemical binding]; other site 281309004374 metal binding triad [ion binding]; metal-binding site 281309004375 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 281309004376 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 281309004377 Biotin operon repressor [Transcription]; Region: BirA; COG1654 281309004378 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 281309004379 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 281309004380 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 281309004381 Uncharacterized subfamiy of Cupredoxin; Region: Cupredoxin_like_3; cd04203 281309004382 Type 1 (T1) Cu binding site [ion binding]; other site 281309004383 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 281309004384 oligomerization interface [polypeptide binding]; other site 281309004385 active site 281309004386 metal binding site [ion binding]; metal-binding site 281309004387 Pantoate-beta-alanine ligase; Region: PanC; cd00560 281309004388 active site 281309004389 ATP-binding site [chemical binding]; other site 281309004390 pantoate-binding site; other site 281309004391 HXXH motif; other site 281309004392 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 281309004393 tetramerization interface [polypeptide binding]; other site 281309004394 active site 281309004395 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 281309004396 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 281309004397 active site 281309004398 catalytic site [active] 281309004399 substrate binding site [chemical binding]; other site 281309004400 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 281309004401 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 281309004402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 281309004403 aspartate aminotransferase; Provisional; Region: PRK05764 281309004404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309004405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309004406 homodimer interface [polypeptide binding]; other site 281309004407 catalytic residue [active] 281309004408 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 281309004409 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 281309004410 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 281309004411 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 281309004412 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 281309004413 minor groove reading motif; other site 281309004414 helix-hairpin-helix signature motif; other site 281309004415 substrate binding pocket [chemical binding]; other site 281309004416 active site 281309004417 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 281309004418 Transglycosylase; Region: Transgly; pfam00912 281309004419 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281309004420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309004421 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 281309004422 Interdomain contacts; other site 281309004423 Cytokine receptor motif; other site 281309004424 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 281309004425 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 281309004426 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 281309004427 YppF-like protein; Region: YppF; pfam14178 281309004428 YppG-like protein; Region: YppG; pfam14179 281309004429 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 281309004430 hypothetical protein; Provisional; Region: PRK13660 281309004431 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 281309004432 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 281309004433 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 281309004434 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 281309004435 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 281309004436 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 281309004437 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 281309004438 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 281309004439 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 281309004440 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 281309004441 active site 281309004442 Zn binding site [ion binding]; other site 281309004443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309004444 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309004445 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 281309004446 Phosphotransferase enzyme family; Region: APH; pfam01636 281309004447 putative active site [active] 281309004448 putative substrate binding site [chemical binding]; other site 281309004449 ATP binding site [chemical binding]; other site 281309004450 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 281309004451 active site 281309004452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309004453 active site 281309004454 Sulfate transporter family; Region: Sulfate_transp; cl19250 281309004455 xanthine permease; Region: pbuX; TIGR03173 281309004456 Predicted membrane protein [Function unknown]; Region: COG2311 281309004457 Protein of unknown function (DUF418); Region: DUF418; pfam04235 281309004458 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 281309004459 G1 box; other site 281309004460 GTP/Mg2+ binding site [chemical binding]; other site 281309004461 G2 box; other site 281309004462 Switch I region; other site 281309004463 G3 box; other site 281309004464 Switch II region; other site 281309004465 G4 box; other site 281309004466 G5 box; other site 281309004467 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 281309004468 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 281309004469 G1 box; other site 281309004470 G1 box; other site 281309004471 GTP/Mg2+ binding site [chemical binding]; other site 281309004472 GTP/Mg2+ binding site [chemical binding]; other site 281309004473 G2 box; other site 281309004474 Switch I region; other site 281309004475 G3 box; other site 281309004476 Switch II region; other site 281309004477 G4 box; other site 281309004478 G5 box; other site 281309004479 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 281309004480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309004481 Coenzyme A binding pocket [chemical binding]; other site 281309004482 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 281309004483 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 281309004484 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 281309004485 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 281309004486 active site residue [active] 281309004487 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 281309004488 active site residue [active] 281309004489 Probable transposase; Region: OrfB_IS605; pfam01385 281309004490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309004491 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309004492 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 281309004493 Predicted membrane protein [Function unknown]; Region: COG3766 281309004494 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 281309004495 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 281309004496 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 281309004497 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309004498 5'-3' exonuclease; Region: 53EXOc; smart00475 281309004499 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 281309004500 active site 281309004501 metal binding site 1 [ion binding]; metal-binding site 281309004502 putative 5' ssDNA interaction site; other site 281309004503 metal binding site 3; metal-binding site 281309004504 metal binding site 2 [ion binding]; metal-binding site 281309004505 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 281309004506 putative DNA binding site [nucleotide binding]; other site 281309004507 putative metal binding site [ion binding]; other site 281309004508 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 281309004509 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 281309004510 Chain length determinant protein; Region: Wzz; pfam02706 281309004511 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 281309004512 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 281309004513 Bacterial sugar transferase; Region: Bac_transf; pfam02397 281309004514 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 281309004515 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 281309004516 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 281309004517 O-Antigen ligase; Region: Wzy_C; pfam04932 281309004518 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309004519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281309004520 active site 281309004521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281309004522 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 281309004523 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 281309004524 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004525 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004526 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004527 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004528 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004529 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004530 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004531 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004532 Domain of unknown function DUF11; Region: DUF11; cl17728 281309004533 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004534 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004535 Domain of unknown function DUF11; Region: DUF11; cl17728 281309004536 Domain of unknown function DUF11; Region: DUF11; cl17728 281309004537 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004538 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004539 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004540 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004541 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004542 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004543 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004544 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004545 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004546 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004547 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004548 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004549 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004550 Domain of unknown function DUF11; Region: DUF11; cl17728 281309004551 Domain of unknown function DUF11; Region: DUF11; cl17728 281309004552 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004553 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004554 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309004555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309004556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309004557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309004558 Coenzyme A binding pocket [chemical binding]; other site 281309004559 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 281309004560 catalytic triad [active] 281309004561 conserved cis-peptide bond; other site 281309004562 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309004563 EamA-like transporter family; Region: EamA; pfam00892 281309004564 EamA-like transporter family; Region: EamA; pfam00892 281309004565 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 281309004566 RNA/DNA hybrid binding site [nucleotide binding]; other site 281309004567 active site 281309004568 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 281309004569 active site 281309004570 catalytic residues [active] 281309004571 QueT transporter; Region: QueT; pfam06177 281309004572 hypothetical protein; Validated; Region: PRK07708 281309004573 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 281309004574 RNA/DNA hybrid binding site [nucleotide binding]; other site 281309004575 active site 281309004576 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 281309004577 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281309004578 DNA-binding site [nucleotide binding]; DNA binding site 281309004579 RNA-binding motif; other site 281309004580 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 281309004581 LysE type translocator; Region: LysE; cl00565 281309004582 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 281309004583 Protein of unknown function, DUF485; Region: DUF485; pfam04341 281309004584 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 281309004585 Na binding site [ion binding]; other site 281309004586 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309004587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309004588 inhibitor-cofactor binding pocket; inhibition site 281309004589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309004590 catalytic residue [active] 281309004591 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 281309004592 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 281309004593 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 281309004594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309004595 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 281309004596 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309004597 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 281309004598 DNA binding residues [nucleotide binding] 281309004599 drug binding residues [chemical binding]; other site 281309004600 dimer interface [polypeptide binding]; other site 281309004601 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 281309004602 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 281309004603 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 281309004604 Predicted membrane protein [Function unknown]; Region: COG2323 281309004605 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 281309004606 putative active site [active] 281309004607 Tic20-like protein; Region: Tic20; pfam09685 281309004608 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 281309004609 dimer interface [polypeptide binding]; other site 281309004610 FMN binding site [chemical binding]; other site 281309004611 NADPH bind site [chemical binding]; other site 281309004612 DJ-1 family protein; Region: not_thiJ; TIGR01383 281309004613 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 281309004614 conserved cys residue [active] 281309004615 RNA polymerase factor sigma-70; Validated; Region: PRK06811 281309004616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309004617 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281309004618 DNA binding residues [nucleotide binding] 281309004619 Pleckstrin homology-like domain; Region: PH-like; cl17171 281309004620 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 281309004621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309004622 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309004623 putative substrate translocation pore; other site 281309004624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309004625 dimerization interface [polypeptide binding]; other site 281309004626 putative DNA binding site [nucleotide binding]; other site 281309004627 putative Zn2+ binding site [ion binding]; other site 281309004628 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309004629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309004630 putative substrate translocation pore; other site 281309004631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 281309004632 active site 281309004633 metal binding site [ion binding]; metal-binding site 281309004634 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 281309004635 bacterial Hfq-like; Region: Hfq; cd01716 281309004636 hexamer interface [polypeptide binding]; other site 281309004637 Sm1 motif; other site 281309004638 RNA binding site [nucleotide binding]; other site 281309004639 Sm2 motif; other site 281309004640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309004641 Transposase domain (DUF772); Region: DUF772; pfam05598 281309004642 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309004643 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309004644 HD domain; Region: HD_3; pfam13023 281309004645 flagellar motor protein MotP; Reviewed; Region: PRK06743 281309004646 flagellar motor protein MotS; Reviewed; Region: PRK06742 281309004647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 281309004648 ligand binding site [chemical binding]; other site 281309004649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309004650 active site 281309004651 phosphorylation site [posttranslational modification] 281309004652 intermolecular recognition site; other site 281309004653 dimerization interface [polypeptide binding]; other site 281309004654 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 281309004655 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 281309004656 putative binding surface; other site 281309004657 active site 281309004658 P2 response regulator binding domain; Region: P2; pfam07194 281309004659 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 281309004660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004661 ATP binding site [chemical binding]; other site 281309004662 Mg2+ binding site [ion binding]; other site 281309004663 G-X-G motif; other site 281309004664 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 281309004665 flagellar motor switch protein; Reviewed; Region: PRK06782 281309004666 CheC-like family; Region: CheC; pfam04509 281309004667 CheC-like family; Region: CheC; pfam04509 281309004668 CheC-like family; Region: CheC; pfam04509 281309004669 CheC-like family; Region: CheC; pfam04509 281309004670 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 281309004671 ribonuclease Y; Region: RNase_Y; TIGR03319 281309004672 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 281309004673 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 281309004674 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 281309004675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309004676 Protein of unknown function (DUF327); Region: DUF327; pfam03885 281309004677 Glutamate-cysteine ligase; Region: GshA; cl19621 281309004678 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 281309004679 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 281309004680 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 281309004681 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 281309004682 flagellar capping protein; Validated; Region: fliD; PRK06798 281309004683 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 281309004684 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 281309004685 Flagellar protein FliS; Region: FliS; cl00654 281309004686 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 281309004687 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 281309004688 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 281309004689 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 281309004690 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 281309004691 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 281309004692 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 281309004693 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 281309004694 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 281309004695 FliG N-terminal domain; Region: FliG_N; pfam14842 281309004696 FliG middle domain; Region: FliG_M; pfam14841 281309004697 FliG C-terminal domain; Region: FliG_C; pfam01706 281309004698 flagellar assembly protein H; Validated; Region: fliH; PRK06800 281309004699 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 281309004700 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 281309004701 Walker A motif; other site 281309004702 ATP binding site [chemical binding]; other site 281309004703 Walker B motif; other site 281309004704 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 281309004705 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 281309004706 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 281309004707 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 281309004708 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 281309004709 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 281309004710 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 281309004711 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 281309004712 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 281309004713 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 281309004714 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 281309004715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309004716 active site 281309004717 phosphorylation site [posttranslational modification] 281309004718 intermolecular recognition site; other site 281309004719 dimerization interface [polypeptide binding]; other site 281309004720 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 281309004721 flagellin; Provisional; Region: PRK12807 281309004722 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 281309004723 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 281309004724 flagellin; Provisional; Region: PRK12808 281309004725 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 281309004726 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 281309004727 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 281309004728 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 281309004729 N-acetyl-D-glucosamine binding site [chemical binding]; other site 281309004730 catalytic residue [active] 281309004731 flagellar motor switch protein; Validated; Region: PRK06789 281309004732 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 281309004733 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 281309004734 flagellar motor switch protein; Validated; Region: PRK06788 281309004735 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 281309004736 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 281309004737 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 281309004738 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 281309004739 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 281309004740 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 281309004741 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 281309004742 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 281309004743 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 281309004744 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 281309004745 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 281309004746 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 281309004747 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 281309004748 Predicted transcriptional regulators [Transcription]; Region: COG1378 281309004749 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 281309004750 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 281309004751 C-terminal domain interface [polypeptide binding]; other site 281309004752 sugar binding site [chemical binding]; other site 281309004753 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 281309004754 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 281309004755 Dienelactone hydrolase family; Region: DLH; pfam01738 281309004756 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 281309004757 transcriptional repressor DicA; Reviewed; Region: PRK09706 281309004758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309004759 non-specific DNA binding site [nucleotide binding]; other site 281309004760 salt bridge; other site 281309004761 sequence-specific DNA binding site [nucleotide binding]; other site 281309004762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309004763 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309004764 putative substrate translocation pore; other site 281309004765 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 281309004766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309004767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309004768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309004769 dimerization interface [polypeptide binding]; other site 281309004770 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 281309004771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309004772 Walker A/P-loop; other site 281309004773 ATP binding site [chemical binding]; other site 281309004774 Q-loop/lid; other site 281309004775 ABC transporter signature motif; other site 281309004776 Walker B; other site 281309004777 D-loop; other site 281309004778 H-loop/switch region; other site 281309004779 TOBE domain; Region: TOBE_2; pfam08402 281309004780 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 281309004781 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 281309004782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309004783 dimer interface [polypeptide binding]; other site 281309004784 conserved gate region; other site 281309004785 putative PBP binding loops; other site 281309004786 ABC-ATPase subunit interface; other site 281309004787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309004788 dimer interface [polypeptide binding]; other site 281309004789 conserved gate region; other site 281309004790 putative PBP binding loops; other site 281309004791 ABC-ATPase subunit interface; other site 281309004792 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 281309004793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 281309004794 Beta-Casp domain; Region: Beta-Casp; pfam10996 281309004795 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 281309004796 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 281309004797 Cupin; Region: Cupin_1; smart00835 281309004798 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309004799 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 281309004800 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309004801 catalytic core [active] 281309004802 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309004803 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309004804 hypothetical protein; Provisional; Region: PRK09272 281309004805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309004806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309004807 dimerization interface [polypeptide binding]; other site 281309004808 putative Zn2+ binding site [ion binding]; other site 281309004809 putative DNA binding site [nucleotide binding]; other site 281309004810 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 281309004811 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 281309004812 active site 281309004813 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 281309004814 dimer interface [polypeptide binding]; other site 281309004815 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 281309004816 Ligand Binding Site [chemical binding]; other site 281309004817 Molecular Tunnel; other site 281309004818 RNA polymerase factor sigma-70; Validated; Region: PRK06811 281309004819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309004820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309004821 DNA binding residues [nucleotide binding] 281309004822 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 281309004823 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 281309004824 active site 281309004825 metal binding site [ion binding]; metal-binding site 281309004826 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 281309004827 domain I; other site 281309004828 DNA binding groove [nucleotide binding] 281309004829 phosphate binding site [ion binding]; other site 281309004830 domain III; other site 281309004831 nucleotide binding site [chemical binding]; other site 281309004832 catalytic site [active] 281309004833 bacterial Hfq-like; Region: Hfq; cd01716 281309004834 hexamer interface [polypeptide binding]; other site 281309004835 Sm1 motif; other site 281309004836 RNA binding site [nucleotide binding]; other site 281309004837 Sm2 motif; other site 281309004838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309004839 Homeodomain-like domain; Region: HTH_23; pfam13384 281309004840 HTH-like domain; Region: HTH_21; pfam13276 281309004841 Integrase core domain; Region: rve; pfam00665 281309004842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309004843 TPR motif; other site 281309004844 binding surface 281309004845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309004846 FtsX-like permease family; Region: FtsX; pfam02687 281309004847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309004848 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309004849 Walker A/P-loop; other site 281309004850 ATP binding site [chemical binding]; other site 281309004851 Q-loop/lid; other site 281309004852 ABC transporter signature motif; other site 281309004853 Walker B; other site 281309004854 D-loop; other site 281309004855 H-loop/switch region; other site 281309004856 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 281309004857 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281309004858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309004859 DNA-binding site [nucleotide binding]; DNA binding site 281309004860 FCD domain; Region: FCD; pfam07729 281309004861 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309004862 EamA-like transporter family; Region: EamA; pfam00892 281309004863 EamA-like transporter family; Region: EamA; pfam00892 281309004864 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 281309004865 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 281309004866 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 281309004867 Predicted permeases [General function prediction only]; Region: COG0701 281309004868 TIGR03943 family protein; Region: TIGR03943 281309004869 Methyltransferase domain; Region: Methyltransf_24; pfam13578 281309004870 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 281309004871 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281309004872 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 281309004873 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309004874 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 281309004875 DNA binding residues [nucleotide binding] 281309004876 putative dimer interface [polypeptide binding]; other site 281309004877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309004878 short chain dehydrogenase; Region: adh_short; pfam00106 281309004879 NAD(P) binding site [chemical binding]; other site 281309004880 active site 281309004881 fumarate hydratase; Reviewed; Region: fumC; PRK00485 281309004882 Class II fumarases; Region: Fumarase_classII; cd01362 281309004883 active site 281309004884 tetramer interface [polypeptide binding]; other site 281309004885 Bacterial PH domain; Region: bPH_4; pfam06713 281309004886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309004887 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 281309004888 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 281309004889 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 281309004890 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 281309004891 active site pocket [active] 281309004892 oxyanion hole [active] 281309004893 catalytic triad [active] 281309004894 active site nucleophile [active] 281309004895 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 281309004896 Penicillinase repressor; Region: Penicillinase_R; pfam03965 281309004897 Peptidase family M48; Region: Peptidase_M48; cl12018 281309004898 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 281309004899 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 281309004900 catalytic residues [active] 281309004901 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 281309004902 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 281309004903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309004904 non-specific DNA binding site [nucleotide binding]; other site 281309004905 salt bridge; other site 281309004906 sequence-specific DNA binding site [nucleotide binding]; other site 281309004907 Cupin domain; Region: Cupin_2; pfam07883 281309004908 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 281309004909 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309004910 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 281309004911 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309004912 catalytic residue [active] 281309004913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 281309004914 Protein of unknown function (DUF445); Region: DUF445; pfam04286 281309004915 Uncharacterized protein KIAA1328; Region: KIAA1328; pfam15369 281309004916 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 281309004917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309004918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309004919 DNA binding residues [nucleotide binding] 281309004920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309004921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309004922 active site 281309004923 phosphorylation site [posttranslational modification] 281309004924 intermolecular recognition site; other site 281309004925 dimerization interface [polypeptide binding]; other site 281309004926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309004927 DNA binding residues [nucleotide binding] 281309004928 dimerization interface [polypeptide binding]; other site 281309004929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309004930 Histidine kinase; Region: HisKA_3; pfam07730 281309004931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004932 Mg2+ binding site [ion binding]; other site 281309004933 G-X-G motif; other site 281309004934 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309004935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309004936 Walker A/P-loop; other site 281309004937 ATP binding site [chemical binding]; other site 281309004938 Q-loop/lid; other site 281309004939 ABC transporter signature motif; other site 281309004940 Walker B; other site 281309004941 D-loop; other site 281309004942 H-loop/switch region; other site 281309004943 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 281309004944 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 281309004945 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 281309004946 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 281309004947 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 281309004948 PLD-like domain; Region: PLDc_2; pfam13091 281309004949 putative active site [active] 281309004950 catalytic site [active] 281309004951 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 281309004952 PLD-like domain; Region: PLDc_2; pfam13091 281309004953 putative active site [active] 281309004954 catalytic site [active] 281309004955 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 281309004956 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 281309004957 LXG domain of WXG superfamily; Region: LXG; pfam04740 281309004958 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 281309004959 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 281309004960 putative nucleotide binding site [chemical binding]; other site 281309004961 uridine monophosphate binding site [chemical binding]; other site 281309004962 homohexameric interface [polypeptide binding]; other site 281309004963 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 281309004964 aspartate ammonia-lyase; Provisional; Region: PRK14515 281309004965 Aspartase; Region: Aspartase; cd01357 281309004966 active sites [active] 281309004967 tetramer interface [polypeptide binding]; other site 281309004968 malate dehydrogenase; Provisional; Region: PRK13529 281309004969 Malic enzyme, N-terminal domain; Region: malic; pfam00390 281309004970 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 281309004971 NAD(P) binding site [chemical binding]; other site 281309004972 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 281309004973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309004974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309004975 ATP binding site [chemical binding]; other site 281309004976 Mg2+ binding site [ion binding]; other site 281309004977 G-X-G motif; other site 281309004978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309004979 active site 281309004980 phosphorylation site [posttranslational modification] 281309004981 intermolecular recognition site; other site 281309004982 dimerization interface [polypeptide binding]; other site 281309004983 YcbB domain; Region: YcbB; pfam08664 281309004984 SWIM zinc finger; Region: SWIM; pfam04434 281309004985 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 281309004986 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 281309004987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309004988 ATP binding site [chemical binding]; other site 281309004989 putative Mg++ binding site [ion binding]; other site 281309004990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309004991 nucleotide binding region [chemical binding]; other site 281309004992 ATP-binding site [chemical binding]; other site 281309004993 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 281309004994 dimer interface [polypeptide binding]; other site 281309004995 active site 281309004996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309004997 salt bridge; other site 281309004998 aspartate kinase; Reviewed; Region: PRK06635 281309004999 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 281309005000 putative nucleotide binding site [chemical binding]; other site 281309005001 putative catalytic residues [active] 281309005002 putative Mg ion binding site [ion binding]; other site 281309005003 putative aspartate binding site [chemical binding]; other site 281309005004 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 281309005005 putative allosteric regulatory site; other site 281309005006 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 281309005007 DoxX-like family; Region: DoxX_3; pfam13781 281309005008 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 281309005009 YndJ-like protein; Region: YndJ; pfam14158 281309005010 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 281309005011 putative active site [active] 281309005012 nucleotide binding site [chemical binding]; other site 281309005013 nudix motif; other site 281309005014 putative metal binding site [ion binding]; other site 281309005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005016 putative substrate translocation pore; other site 281309005017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005018 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 281309005019 Carbon starvation protein CstA; Region: CstA; pfam02554 281309005020 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 281309005021 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 281309005022 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309005023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309005025 putative substrate translocation pore; other site 281309005026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309005028 putative substrate translocation pore; other site 281309005029 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 281309005030 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 281309005031 dimer interface [polypeptide binding]; other site 281309005032 active site 281309005033 CoA binding pocket [chemical binding]; other site 281309005034 NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by...; Region: NTR_TIMP_like; cd03577 281309005035 Metzincin-binding interface; other site 281309005036 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 281309005037 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 281309005038 HflX GTPase family; Region: HflX; cd01878 281309005039 G1 box; other site 281309005040 GTP/Mg2+ binding site [chemical binding]; other site 281309005041 Switch I region; other site 281309005042 G2 box; other site 281309005043 G3 box; other site 281309005044 Switch II region; other site 281309005045 G4 box; other site 281309005046 G5 box; other site 281309005047 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309005048 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 281309005049 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309005050 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309005051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309005053 putative substrate translocation pore; other site 281309005054 cysteine synthase; Region: PLN02565 281309005055 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 281309005056 dimer interface [polypeptide binding]; other site 281309005057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309005058 catalytic residue [active] 281309005059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309005061 Coenzyme A binding pocket [chemical binding]; other site 281309005062 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 281309005063 stage V sporulation protein B; Region: spore_V_B; TIGR02900 281309005064 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 281309005065 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 281309005066 Na2 binding site [ion binding]; other site 281309005067 putative substrate binding site 1 [chemical binding]; other site 281309005068 Na binding site 1 [ion binding]; other site 281309005069 putative substrate binding site 2 [chemical binding]; other site 281309005070 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309005071 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 281309005072 NodB motif; other site 281309005073 putative active site [active] 281309005074 putative catalytic site [active] 281309005075 putative Zn binding site [ion binding]; other site 281309005076 Mor transcription activator family; Region: Mor; cl02360 281309005077 Predicted membrane protein [Function unknown]; Region: COG2323 281309005078 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 281309005079 methionine sulfoxide reductase A; Provisional; Region: PRK14054 281309005080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 281309005081 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 281309005082 NADP binding site [chemical binding]; other site 281309005083 homodimer interface [polypeptide binding]; other site 281309005084 active site 281309005085 substrate binding site [chemical binding]; other site 281309005086 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 281309005087 homodimer interface [polypeptide binding]; other site 281309005088 substrate-cofactor binding pocket; other site 281309005089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309005090 catalytic residue [active] 281309005091 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 281309005092 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 281309005093 PYR/PP interface [polypeptide binding]; other site 281309005094 dimer interface [polypeptide binding]; other site 281309005095 TPP binding site [chemical binding]; other site 281309005096 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281309005097 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 281309005098 TPP-binding site [chemical binding]; other site 281309005099 dimer interface [polypeptide binding]; other site 281309005100 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 281309005101 ketol-acid reductoisomerase; Provisional; Region: PRK05479 281309005102 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 281309005103 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 281309005104 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 281309005105 threonine dehydratase; Validated; Region: PRK08639 281309005106 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 281309005107 tetramer interface [polypeptide binding]; other site 281309005108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309005109 catalytic residue [active] 281309005110 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 281309005111 putative Ile/Val binding site [chemical binding]; other site 281309005112 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 281309005113 putative active site [active] 281309005114 putative metal binding site [ion binding]; other site 281309005115 Protein of unknown function (DUF554); Region: DUF554; pfam04474 281309005116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005117 Coenzyme A binding pocket [chemical binding]; other site 281309005118 drug efflux system protein MdtG; Provisional; Region: PRK09874 281309005119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005120 putative substrate translocation pore; other site 281309005121 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 281309005122 putative active site [active] 281309005123 metal binding site [ion binding]; metal-binding site 281309005124 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 281309005125 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 281309005126 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 281309005127 LytTr DNA-binding domain; Region: LytTR; pfam04397 281309005128 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 281309005129 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 281309005130 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 281309005131 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 281309005132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309005133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005134 Coenzyme A binding pocket [chemical binding]; other site 281309005135 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 281309005136 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 281309005137 active site 281309005138 putative substrate binding pocket [chemical binding]; other site 281309005139 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309005140 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309005141 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309005142 peptide binding site [polypeptide binding]; other site 281309005143 hypothetical protein; Provisional; Region: PRK06922 281309005144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309005145 S-adenosylmethionine binding site [chemical binding]; other site 281309005146 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 281309005147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309005148 FeS/SAM binding site; other site 281309005149 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 281309005150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309005151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005152 Coenzyme A binding pocket [chemical binding]; other site 281309005153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309005154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309005155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309005156 active site 281309005157 phosphorylation site [posttranslational modification] 281309005158 intermolecular recognition site; other site 281309005159 dimerization interface [polypeptide binding]; other site 281309005160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309005161 DNA binding site [nucleotide binding] 281309005162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309005163 Predicted membrane protein (DUF2208); Region: DUF2208; cl09219 281309005164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309005165 dimerization interface [polypeptide binding]; other site 281309005166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309005167 dimer interface [polypeptide binding]; other site 281309005168 phosphorylation site [posttranslational modification] 281309005169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309005170 ATP binding site [chemical binding]; other site 281309005171 Mg2+ binding site [ion binding]; other site 281309005172 G-X-G motif; other site 281309005173 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309005174 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309005175 manganese transport protein MntH; Reviewed; Region: PRK00701 281309005176 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 281309005177 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 281309005178 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 281309005179 active site residue [active] 281309005180 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 281309005181 Probable transposase; Region: OrfB_IS605; pfam01385 281309005182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309005183 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309005184 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309005185 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 281309005186 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 281309005187 K+ potassium transporter; Region: K_trans; cl15781 281309005188 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309005189 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309005190 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309005191 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 281309005192 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 281309005193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 281309005194 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 281309005195 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 281309005196 intersubunit interface [polypeptide binding]; other site 281309005197 active site 281309005198 catalytic residue [active] 281309005199 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309005200 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309005201 Nucleoside recognition; Region: Gate; pfam07670 281309005202 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309005203 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 281309005204 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 281309005205 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 281309005206 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 281309005207 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 281309005208 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 281309005209 active site 281309005210 catalytic motif [active] 281309005211 Zn binding site [ion binding]; other site 281309005212 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 281309005213 hypothetical protein; Provisional; Region: PRK01631 281309005214 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 281309005215 VPS10 domain; Region: VPS10; smart00602 281309005216 proline aminopeptidase P II; Provisional; Region: PRK10879 281309005217 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 281309005218 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 281309005219 active site 281309005220 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 281309005221 The first cupredoxin domain of bacteria two domain multicopper oxidase; Region: CuRO_1_2dMco_1; cd13860 281309005222 putative trimer interface [polypeptide binding]; other site 281309005223 trinuclear Cu binding site [ion binding]; other site 281309005224 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 281309005225 trimer interface [polypeptide binding]; other site 281309005226 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 281309005227 trimer interface [polypeptide binding]; other site 281309005228 trinuclear Cu binding site [ion binding]; other site 281309005229 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005230 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005231 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005232 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005233 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309005234 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005235 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309005236 DNA topoisomerase III; Provisional; Region: PRK07726 281309005237 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 281309005238 active site 281309005239 putative interdomain interaction site [polypeptide binding]; other site 281309005240 putative metal-binding site [ion binding]; other site 281309005241 putative nucleotide binding site [chemical binding]; other site 281309005242 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 281309005243 domain I; other site 281309005244 DNA binding groove [nucleotide binding] 281309005245 phosphate binding site [ion binding]; other site 281309005246 domain II; other site 281309005247 domain III; other site 281309005248 nucleotide binding site [chemical binding]; other site 281309005249 catalytic site [active] 281309005250 domain IV; other site 281309005251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 281309005252 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 281309005253 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 281309005254 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309005255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005256 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309005257 putative substrate translocation pore; other site 281309005258 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 281309005259 azoreductase; Provisional; Region: PRK13555 281309005260 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 281309005261 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 281309005262 dimer interface [polypeptide binding]; other site 281309005263 substrate binding site [chemical binding]; other site 281309005264 metal binding site [ion binding]; metal-binding site 281309005265 CopC domain; Region: CopC; pfam04234 281309005266 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 281309005267 YtkA-like; Region: YtkA; pfam13115 281309005268 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 281309005269 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309005270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309005271 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309005272 EamA-like transporter family; Region: EamA; pfam00892 281309005273 EamA-like transporter family; Region: EamA; pfam00892 281309005274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309005275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309005276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309005277 dimerization interface [polypeptide binding]; other site 281309005278 Rrf2 family protein; Region: rrf2_super; TIGR00738 281309005279 Transcriptional regulator; Region: Rrf2; pfam02082 281309005280 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 281309005281 catalytic residues [active] 281309005282 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 281309005283 dimer interface [polypeptide binding]; other site 281309005284 FMN binding site [chemical binding]; other site 281309005285 amidase; Provisional; Region: PRK06707 281309005286 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281309005287 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 281309005288 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 281309005289 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309005290 NAD binding site [chemical binding]; other site 281309005291 dimer interface [polypeptide binding]; other site 281309005292 substrate binding site [chemical binding]; other site 281309005293 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 281309005294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281309005295 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 281309005296 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 281309005297 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 281309005298 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 281309005299 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 281309005300 putative ligand binding site [chemical binding]; other site 281309005301 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 281309005302 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 281309005303 Walker A/P-loop; other site 281309005304 ATP binding site [chemical binding]; other site 281309005305 Q-loop/lid; other site 281309005306 ABC transporter signature motif; other site 281309005307 Walker B; other site 281309005308 D-loop; other site 281309005309 H-loop/switch region; other site 281309005310 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 281309005311 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 281309005312 Walker A/P-loop; other site 281309005313 ATP binding site [chemical binding]; other site 281309005314 Q-loop/lid; other site 281309005315 ABC transporter signature motif; other site 281309005316 Walker B; other site 281309005317 D-loop; other site 281309005318 H-loop/switch region; other site 281309005319 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 281309005320 TM-ABC transporter signature motif; other site 281309005321 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 281309005322 TM-ABC transporter signature motif; other site 281309005323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309005324 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 281309005325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 281309005326 dimerization interface [polypeptide binding]; other site 281309005327 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 281309005328 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309005329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309005330 putative Zn2+ binding site [ion binding]; other site 281309005331 putative DNA binding site [nucleotide binding]; other site 281309005332 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 281309005333 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 281309005334 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 281309005335 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 281309005336 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 281309005337 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 281309005338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309005339 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 281309005340 Walker A/P-loop; other site 281309005341 ATP binding site [chemical binding]; other site 281309005342 Q-loop/lid; other site 281309005343 ABC transporter signature motif; other site 281309005344 Walker B; other site 281309005345 D-loop; other site 281309005346 H-loop/switch region; other site 281309005347 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 281309005348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309005349 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 281309005350 Walker A/P-loop; other site 281309005351 ATP binding site [chemical binding]; other site 281309005352 Q-loop/lid; other site 281309005353 ABC transporter signature motif; other site 281309005354 Walker B; other site 281309005355 D-loop; other site 281309005356 H-loop/switch region; other site 281309005357 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 281309005358 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 281309005359 putative dimer interface [polypeptide binding]; other site 281309005360 catalytic triad [active] 281309005361 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309005362 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309005363 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 281309005364 dimer interface [polypeptide binding]; other site 281309005365 FMN binding site [chemical binding]; other site 281309005366 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005367 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005368 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309005369 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 281309005370 NlpC/P60 family; Region: NLPC_P60; pfam00877 281309005371 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309005372 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309005373 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309005374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309005375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309005376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309005377 Walker A/P-loop; other site 281309005378 ATP binding site [chemical binding]; other site 281309005379 Q-loop/lid; other site 281309005380 ABC transporter signature motif; other site 281309005381 Walker B; other site 281309005382 D-loop; other site 281309005383 H-loop/switch region; other site 281309005384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309005385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309005386 active site 281309005387 phosphorylation site [posttranslational modification] 281309005388 intermolecular recognition site; other site 281309005389 dimerization interface [polypeptide binding]; other site 281309005390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309005391 DNA binding site [nucleotide binding] 281309005392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309005393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309005394 dimerization interface [polypeptide binding]; other site 281309005395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309005396 dimer interface [polypeptide binding]; other site 281309005397 phosphorylation site [posttranslational modification] 281309005398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309005399 ATP binding site [chemical binding]; other site 281309005400 Mg2+ binding site [ion binding]; other site 281309005401 G-X-G motif; other site 281309005402 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 281309005403 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 281309005404 classical (c) SDRs; Region: SDR_c; cd05233 281309005405 NAD(P) binding site [chemical binding]; other site 281309005406 active site 281309005407 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 281309005408 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309005409 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 281309005410 NodB motif; other site 281309005411 active site 281309005412 catalytic site [active] 281309005413 metal binding site [ion binding]; metal-binding site 281309005414 SdpI/YhfL protein family; Region: SdpI; pfam13630 281309005415 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 281309005416 nudix motif; other site 281309005417 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 281309005418 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 281309005419 homoserine dehydrogenase; Provisional; Region: PRK06349 281309005420 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 281309005421 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 281309005422 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 281309005423 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 281309005424 cysteine synthase; Region: PLN02565 281309005425 homodimer interface [polypeptide binding]; other site 281309005426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309005427 catalytic residue [active] 281309005428 homoserine kinase; Provisional; Region: PRK01212 281309005429 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 281309005430 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 281309005431 Protein of unknown function (DUF1183); Region: DUF1183; pfam06682 281309005432 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 281309005433 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 281309005434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309005435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309005436 active site 281309005437 phosphorylation site [posttranslational modification] 281309005438 intermolecular recognition site; other site 281309005439 dimerization interface [polypeptide binding]; other site 281309005440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309005441 DNA binding site [nucleotide binding] 281309005442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309005443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309005444 dimerization interface [polypeptide binding]; other site 281309005445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309005446 dimer interface [polypeptide binding]; other site 281309005447 phosphorylation site [posttranslational modification] 281309005448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309005449 ATP binding site [chemical binding]; other site 281309005450 Mg2+ binding site [ion binding]; other site 281309005451 G-X-G motif; other site 281309005452 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309005453 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 281309005454 NodB motif; other site 281309005455 active site 281309005456 catalytic site [active] 281309005457 Zn binding site [ion binding]; other site 281309005458 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 281309005459 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 281309005460 MgtC family; Region: MgtC; pfam02308 281309005461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309005462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005463 Coenzyme A binding pocket [chemical binding]; other site 281309005464 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 281309005465 IucA / IucC family; Region: IucA_IucC; pfam04183 281309005466 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 281309005467 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 281309005468 IucA / IucC family; Region: IucA_IucC; pfam04183 281309005469 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 281309005470 acyl-CoA synthetase; Validated; Region: PRK08308 281309005471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309005472 acyl-activating enzyme (AAE) consensus motif; other site 281309005473 AMP binding site [chemical binding]; other site 281309005474 active site 281309005475 CoA binding site [chemical binding]; other site 281309005476 acyl carrier protein; Provisional; Region: PRK07639 281309005477 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 281309005478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 281309005479 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309005480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309005482 putative substrate translocation pore; other site 281309005483 Lysine efflux permease [General function prediction only]; Region: COG1279 281309005484 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 281309005485 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 281309005486 active site 281309005487 nucleophile elbow; other site 281309005488 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 281309005489 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 281309005490 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 281309005491 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 281309005492 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 281309005493 nudix motif; other site 281309005494 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 281309005495 homodimer interface [polypeptide binding]; other site 281309005496 NAD binding pocket [chemical binding]; other site 281309005497 ATP binding pocket [chemical binding]; other site 281309005498 Mg binding site [ion binding]; other site 281309005499 active-site loop [active] 281309005500 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309005501 FtsX-like permease family; Region: FtsX; pfam02687 281309005502 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 281309005503 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 281309005504 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 281309005505 Subtilase family; Region: Peptidase_S8; pfam00082 281309005506 active site 281309005507 catalytic residues [active] 281309005508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309005509 dimerization interface [polypeptide binding]; other site 281309005510 putative DNA binding site [nucleotide binding]; other site 281309005511 putative Zn2+ binding site [ion binding]; other site 281309005512 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 281309005513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309005514 active site 281309005515 catalytic tetrad [active] 281309005516 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 281309005517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005518 putative substrate translocation pore; other site 281309005519 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 281309005520 DinB superfamily; Region: DinB_2; pfam12867 281309005521 GTPase RsgA; Reviewed; Region: PRK01889 281309005522 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 281309005523 RNA binding site [nucleotide binding]; other site 281309005524 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 281309005525 GTPase/Zn-binding domain interface [polypeptide binding]; other site 281309005526 GTP/Mg2+ binding site [chemical binding]; other site 281309005527 G4 box; other site 281309005528 G5 box; other site 281309005529 G1 box; other site 281309005530 Switch I region; other site 281309005531 G2 box; other site 281309005532 G3 box; other site 281309005533 Switch II region; other site 281309005534 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 281309005535 Cache domain; Region: Cache_1; pfam02743 281309005536 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 281309005537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309005538 dimerization interface [polypeptide binding]; other site 281309005539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309005540 dimer interface [polypeptide binding]; other site 281309005541 putative CheW interface [polypeptide binding]; other site 281309005542 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 281309005543 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 281309005544 Ferritin-like domain; Region: Ferritin; pfam00210 281309005545 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 281309005546 dimerization interface [polypeptide binding]; other site 281309005547 DPS ferroxidase diiron center [ion binding]; other site 281309005548 ion pore; other site 281309005549 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 281309005550 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 281309005551 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 281309005552 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 281309005553 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 281309005554 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 281309005555 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 281309005556 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 281309005557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281309005558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309005559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309005560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309005561 active site 281309005562 catalytic tetrad [active] 281309005563 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 281309005564 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 281309005565 P-loop, Walker A motif; other site 281309005566 Base recognition motif; other site 281309005567 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 281309005568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309005569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005570 Coenzyme A binding pocket [chemical binding]; other site 281309005571 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 281309005572 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 281309005573 metal binding site [ion binding]; metal-binding site 281309005574 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 281309005575 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 281309005576 NAD binding site [chemical binding]; other site 281309005577 active site 281309005578 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 281309005579 active site 281309005580 FMN binding site [chemical binding]; other site 281309005581 substrate binding site [chemical binding]; other site 281309005582 homotetramer interface [polypeptide binding]; other site 281309005583 catalytic residue [active] 281309005584 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 281309005585 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 281309005586 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 281309005587 DNA binding site [nucleotide binding] 281309005588 active site 281309005589 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 281309005590 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309005591 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309005592 peptide binding site [polypeptide binding]; other site 281309005593 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 281309005594 active site 281309005595 metal binding site [ion binding]; metal-binding site 281309005596 short chain dehydrogenase; Provisional; Region: PRK08309 281309005597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309005598 catalytic core [active] 281309005599 CotH protein; Region: CotH; cl19892 281309005600 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 281309005601 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 281309005602 nudix motif; other site 281309005603 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309005604 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 281309005605 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 281309005606 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 281309005607 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 281309005608 Cl binding site [ion binding]; other site 281309005609 oligomer interface [polypeptide binding]; other site 281309005610 Predicted permeases [General function prediction only]; Region: COG0701 281309005611 Predicted membrane protein [Function unknown]; Region: COG3689 281309005612 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 281309005613 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 281309005614 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 281309005615 putative active site [active] 281309005616 catalytic site [active] 281309005617 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 281309005618 putative active site [active] 281309005619 catalytic site [active] 281309005620 Coat F domain; Region: Coat_F; pfam07875 281309005621 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 281309005622 NAD binding site [chemical binding]; other site 281309005623 substrate binding site [chemical binding]; other site 281309005624 putative active site [active] 281309005625 Protein of unknown function (DUF456); Region: DUF456; pfam04306 281309005626 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281309005627 Domain of unknown function DUF21; Region: DUF21; pfam01595 281309005628 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281309005629 Transporter associated domain; Region: CorC_HlyC; smart01091 281309005630 FOG: CBS domain [General function prediction only]; Region: COG0517 281309005631 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 281309005632 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 281309005633 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 281309005634 dimer interface [polypeptide binding]; other site 281309005635 putative tRNA-binding site [nucleotide binding]; other site 281309005636 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 281309005637 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 281309005638 stage II sporulation protein P; Region: spore_II_P; TIGR02867 281309005639 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309005640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005641 Coenzyme A binding pocket [chemical binding]; other site 281309005642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309005643 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 281309005644 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 281309005645 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 281309005646 nudix motif; other site 281309005647 amidase; Provisional; Region: PRK06828 281309005648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005649 putative substrate translocation pore; other site 281309005650 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309005651 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 281309005652 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 281309005653 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 281309005654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309005655 catalytic core [active] 281309005656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309005657 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 281309005658 active site 281309005659 motif I; other site 281309005660 motif II; other site 281309005661 DinB superfamily; Region: DinB_2; pfam12867 281309005662 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 281309005663 alanine racemase; Reviewed; Region: alr; PRK00053 281309005664 active site 281309005665 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281309005666 dimer interface [polypeptide binding]; other site 281309005667 substrate binding site [chemical binding]; other site 281309005668 catalytic residues [active] 281309005669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 281309005670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309005671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309005672 S-adenosylmethionine binding site [chemical binding]; other site 281309005673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005674 Coenzyme A binding pocket [chemical binding]; other site 281309005675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005676 Coenzyme A binding pocket [chemical binding]; other site 281309005677 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309005678 active site 281309005679 ATP binding site [chemical binding]; other site 281309005680 Phosphotransferase enzyme family; Region: APH; pfam01636 281309005681 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 281309005682 glycosyltransferase, MGT family; Region: MGT; TIGR01426 281309005683 active site 281309005684 TDP-binding site; other site 281309005685 acceptor substrate-binding pocket; other site 281309005686 homodimer interface [polypeptide binding]; other site 281309005687 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309005688 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309005689 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309005690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309005691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309005692 DNA-binding site [nucleotide binding]; DNA binding site 281309005693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309005694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309005695 homodimer interface [polypeptide binding]; other site 281309005696 catalytic residue [active] 281309005697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005698 Coenzyme A binding pocket [chemical binding]; other site 281309005699 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 281309005700 active site 281309005701 metal binding site [ion binding]; metal-binding site 281309005702 Src Homology 3 domain superfamily; Region: SH3; cl17036 281309005703 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309005704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005705 Coenzyme A binding pocket [chemical binding]; other site 281309005706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309005707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309005708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005709 Coenzyme A binding pocket [chemical binding]; other site 281309005710 Cupin domain; Region: Cupin_2; cl17218 281309005711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309005712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005713 Coenzyme A binding pocket [chemical binding]; other site 281309005714 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309005715 Phosphotransferase enzyme family; Region: APH; pfam01636 281309005716 active site 281309005717 substrate binding site [chemical binding]; other site 281309005718 ATP binding site [chemical binding]; other site 281309005719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 281309005720 Predicted membrane protein [Function unknown]; Region: COG1511 281309005721 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 281309005722 CD99 antigen like protein 2; Region: CD99L2; pfam12301 281309005723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 281309005725 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 281309005726 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 281309005727 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 281309005728 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 281309005729 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 281309005730 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 281309005731 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 281309005732 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 281309005733 LXG domain of WXG superfamily; Region: LXG; pfam04740 281309005734 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 281309005735 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 281309005736 Predicted acetyltransferase [General function prediction only]; Region: COG3393 281309005737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005738 Coenzyme A binding pocket [chemical binding]; other site 281309005739 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 281309005740 ornithine carbamoyltransferase; Provisional; Region: PRK00779 281309005741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309005742 S-adenosylmethionine binding site [chemical binding]; other site 281309005743 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 281309005744 Potassium binding sites [ion binding]; other site 281309005745 Cesium cation binding sites [ion binding]; other site 281309005746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 281309005747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281309005748 ATP binding site [chemical binding]; other site 281309005749 putative Mg++ binding site [ion binding]; other site 281309005750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309005751 nucleotide binding region [chemical binding]; other site 281309005752 ATP-binding site [chemical binding]; other site 281309005753 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 281309005754 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 281309005755 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 281309005756 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309005757 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 281309005758 NADP binding site [chemical binding]; other site 281309005759 dimer interface [polypeptide binding]; other site 281309005760 RNA polymerase sigma factor; Provisional; Region: PRK12543 281309005761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309005762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309005763 DNA binding residues [nucleotide binding] 281309005764 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 281309005765 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309005766 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 281309005767 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 281309005768 catalytic residues [active] 281309005769 dimer interface [polypeptide binding]; other site 281309005770 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 281309005771 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 281309005772 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 281309005773 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 281309005774 Protein of unknown function DUF58; Region: DUF58; pfam01882 281309005775 MoxR-like ATPases [General function prediction only]; Region: COG0714 281309005776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309005777 Walker A motif; other site 281309005778 ATP binding site [chemical binding]; other site 281309005779 Walker B motif; other site 281309005780 arginine finger; other site 281309005781 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 281309005782 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 281309005783 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 281309005784 [4Fe-4S] binding site [ion binding]; other site 281309005785 molybdopterin cofactor binding site [chemical binding]; other site 281309005786 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 281309005787 molybdopterin cofactor binding site; other site 281309005788 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 281309005789 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 281309005790 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 281309005791 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 281309005792 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 281309005793 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 281309005794 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 281309005795 ligand binding site [chemical binding]; other site 281309005796 flexible hinge region; other site 281309005797 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 281309005798 putative switch regulator; other site 281309005799 non-specific DNA interactions [nucleotide binding]; other site 281309005800 DNA binding site [nucleotide binding] 281309005801 sequence specific DNA binding site [nucleotide binding]; other site 281309005802 putative cAMP binding site [chemical binding]; other site 281309005803 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 281309005804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309005805 FeS/SAM binding site; other site 281309005806 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 281309005807 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 281309005808 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 281309005809 ATP binding site [chemical binding]; other site 281309005810 substrate interface [chemical binding]; other site 281309005811 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 281309005812 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 281309005813 dimer interface [polypeptide binding]; other site 281309005814 putative functional site; other site 281309005815 putative MPT binding site; other site 281309005816 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 281309005817 MoaE homodimer interface [polypeptide binding]; other site 281309005818 MoaD interaction [polypeptide binding]; other site 281309005819 active site residues [active] 281309005820 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 281309005821 MoaE interaction surface [polypeptide binding]; other site 281309005822 MoeB interaction surface [polypeptide binding]; other site 281309005823 thiocarboxylated glycine; other site 281309005824 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 281309005825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309005826 putative substrate translocation pore; other site 281309005827 Membrane transport protein; Region: Mem_trans; cl09117 281309005828 precorrin-2 dehydrogenase; Validated; Region: PRK06719 281309005829 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 281309005830 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 281309005831 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 281309005832 putative active site [active] 281309005833 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 281309005834 putative active site [active] 281309005835 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 281309005836 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 281309005837 active site 281309005838 SAM binding site [chemical binding]; other site 281309005839 homodimer interface [polypeptide binding]; other site 281309005840 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 281309005841 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 281309005842 [2Fe-2S] cluster binding site [ion binding]; other site 281309005843 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 281309005844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309005845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309005846 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 281309005847 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 281309005848 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 281309005849 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 281309005850 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 281309005851 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 281309005852 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 281309005853 Fe binding site [ion binding]; other site 281309005854 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 281309005855 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 281309005856 Pre-mRNA-splicing factor of RES complex; Region: Bud13; pfam09736 281309005857 Excalibur calcium-binding domain; Region: Excalibur; smart00894 281309005858 N-acetyltransferase; Region: Acetyltransf_2; cl00949 281309005859 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309005860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309005861 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 281309005862 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 281309005863 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 281309005864 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 281309005865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309005866 Zn2+ binding site [ion binding]; other site 281309005867 Mg2+ binding site [ion binding]; other site 281309005868 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309005869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309005870 ABC transporter; Region: ABC_tran_2; pfam12848 281309005871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309005872 Bax inhibitor 1 like; Region: BaxI_1; cl17691 281309005873 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 281309005874 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 281309005875 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 281309005876 dimer interface [polypeptide binding]; other site 281309005877 ssDNA binding site [nucleotide binding]; other site 281309005878 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309005879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309005880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309005881 hypothetical protein; Provisional; Region: PRK06753 281309005882 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 281309005883 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 281309005884 Virulence factor; Region: Virulence_fact; pfam13769 281309005885 HEAT repeats; Region: HEAT_2; pfam13646 281309005886 HEAT repeats; Region: HEAT_2; pfam13646 281309005887 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 281309005888 Protein of unknown function, DUF393; Region: DUF393; pfam04134 281309005889 Disulphide isomerase; Region: Disulph_isomer; pfam06491 281309005890 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 281309005891 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 281309005892 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 281309005893 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 281309005894 active site 281309005895 HIGH motif; other site 281309005896 KMSK motif region; other site 281309005897 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 281309005898 tRNA binding surface [nucleotide binding]; other site 281309005899 anticodon binding site; other site 281309005900 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309005901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309005902 S-adenosylmethionine binding site [chemical binding]; other site 281309005903 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 281309005904 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 281309005905 putative active site [active] 281309005906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309005907 TPR motif; other site 281309005908 binding surface 281309005909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309005910 binding surface 281309005911 TPR motif; other site 281309005912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309005913 binding surface 281309005914 TPR motif; other site 281309005915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309005916 binding surface 281309005917 TPR motif; other site 281309005918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309005919 binding surface 281309005920 TPR motif; other site 281309005921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309005922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309005923 binding surface 281309005924 TPR motif; other site 281309005925 Tetratricopeptide repeat; Region: TPR_9; pfam13371 281309005926 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 281309005927 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 281309005928 active site 281309005929 HIGH motif; other site 281309005930 KMSKS motif; other site 281309005931 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 281309005932 tRNA binding surface [nucleotide binding]; other site 281309005933 anticodon binding site; other site 281309005934 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 281309005935 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 281309005936 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 281309005937 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 281309005938 Zn binding site [ion binding]; other site 281309005939 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 281309005940 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281309005941 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309005942 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309005943 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 281309005944 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 281309005945 Dimer interface [polypeptide binding]; other site 281309005946 anticodon binding site; other site 281309005947 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 281309005948 homodimer interface [polypeptide binding]; other site 281309005949 motif 1; other site 281309005950 motif 2; other site 281309005951 active site 281309005952 motif 3; other site 281309005953 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 281309005954 Na2 binding site [ion binding]; other site 281309005955 putative substrate binding site 1 [chemical binding]; other site 281309005956 Na binding site 1 [ion binding]; other site 281309005957 putative substrate binding site 2 [chemical binding]; other site 281309005958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309005959 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309005960 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 281309005961 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 281309005962 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 281309005963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309005964 active site 281309005965 motif I; other site 281309005966 motif II; other site 281309005967 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 281309005968 fructuronate transporter; Provisional; Region: PRK10034; cl15264 281309005969 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 281309005970 putative active site [active] 281309005971 metal binding site [ion binding]; metal-binding site 281309005972 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 281309005973 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 281309005974 homodimer interaction site [polypeptide binding]; other site 281309005975 cofactor binding site; other site 281309005976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005977 Coenzyme A binding pocket [chemical binding]; other site 281309005978 hypothetical protein; Validated; Region: PRK06769 281309005979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309005980 active site 281309005981 motif I; other site 281309005982 motif II; other site 281309005983 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309005984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309005985 Coenzyme A binding pocket [chemical binding]; other site 281309005986 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 281309005987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309005988 Walker A/P-loop; other site 281309005989 ATP binding site [chemical binding]; other site 281309005990 Q-loop/lid; other site 281309005991 ABC transporter signature motif; other site 281309005992 Walker B; other site 281309005993 D-loop; other site 281309005994 H-loop/switch region; other site 281309005995 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 281309005996 YpjP-like protein; Region: YpjP; pfam14005 281309005997 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 281309005998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309005999 active site 281309006000 motif I; other site 281309006001 motif II; other site 281309006002 hypothetical protein; Provisional; Region: PRK06724 281309006003 active site 281309006004 metal binding site [ion binding]; metal-binding site 281309006005 Phosphotransferase enzyme family; Region: APH; pfam01636 281309006006 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 281309006007 active site 281309006008 ATP binding site [chemical binding]; other site 281309006009 substrate binding site [chemical binding]; other site 281309006010 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309006011 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 281309006012 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 281309006013 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 281309006014 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 281309006015 dimerization interface [polypeptide binding]; other site 281309006016 active site 281309006017 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 281309006018 folate binding site [chemical binding]; other site 281309006019 NADP+ binding site [chemical binding]; other site 281309006020 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 281309006021 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309006022 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 281309006023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309006024 Transposase; Region: HTH_Tnp_1; cl17663 281309006025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309006026 HTH-like domain; Region: HTH_21; pfam13276 281309006027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 281309006028 Integrase core domain; Region: rve; pfam00665 281309006029 Integrase core domain; Region: rve_2; pfam13333 281309006030 azoreductase; Reviewed; Region: PRK00170 281309006031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 281309006032 putative acyl-acceptor binding pocket; other site 281309006033 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 281309006034 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 281309006035 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 281309006036 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 281309006037 EDD domain protein, DegV family; Region: DegV; TIGR00762 281309006038 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 281309006039 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 281309006040 Cu(I) binding site [ion binding]; other site 281309006041 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 281309006042 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 281309006043 putative dimer interface [polypeptide binding]; other site 281309006044 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 281309006045 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 281309006046 active site 281309006047 dimer interface [polypeptide binding]; other site 281309006048 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 281309006049 Ligand Binding Site [chemical binding]; other site 281309006050 Molecular Tunnel; other site 281309006051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309006052 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309006053 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 281309006054 siderophore binding site; other site 281309006055 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 281309006056 homodimer interface [polypeptide binding]; other site 281309006057 substrate-cofactor binding pocket; other site 281309006058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309006059 catalytic residue [active] 281309006060 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 281309006061 FMN binding site [chemical binding]; other site 281309006062 dimer interface [polypeptide binding]; other site 281309006063 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 281309006064 catalytic triad [active] 281309006065 conserved cis-peptide bond; other site 281309006066 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 281309006067 nudix motif; other site 281309006068 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 281309006069 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 281309006070 putative dimer interface [polypeptide binding]; other site 281309006071 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 281309006072 Mechanosensitive ion channel; Region: MS_channel; pfam00924 281309006073 GAF domain; Region: GAF_2; pfam13185 281309006074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309006075 Histidine kinase; Region: HisKA_3; pfam07730 281309006076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309006077 ATP binding site [chemical binding]; other site 281309006078 Mg2+ binding site [ion binding]; other site 281309006079 G-X-G motif; other site 281309006080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309006081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309006082 active site 281309006083 phosphorylation site [posttranslational modification] 281309006084 intermolecular recognition site; other site 281309006085 dimerization interface [polypeptide binding]; other site 281309006086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309006087 DNA binding residues [nucleotide binding] 281309006088 dimerization interface [polypeptide binding]; other site 281309006089 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 281309006090 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 281309006091 putative active site [active] 281309006092 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 281309006093 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 281309006094 NAD binding site [chemical binding]; other site 281309006095 substrate binding site [chemical binding]; other site 281309006096 catalytic Zn binding site [ion binding]; other site 281309006097 tetramer interface [polypeptide binding]; other site 281309006098 structural Zn binding site [ion binding]; other site 281309006099 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309006100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309006101 dimer interface [polypeptide binding]; other site 281309006102 conserved gate region; other site 281309006103 ABC-ATPase subunit interface; other site 281309006104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 281309006105 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309006106 Erythromycin esterase; Region: Erythro_esteras; pfam05139 281309006107 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281309006108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281309006109 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309006110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309006111 active site 281309006112 Predicted flavoprotein [General function prediction only]; Region: COG0431 281309006113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006114 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309006115 putative substrate translocation pore; other site 281309006116 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 281309006117 putative active site [active] 281309006118 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 281309006119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309006120 Walker A/P-loop; other site 281309006121 ATP binding site [chemical binding]; other site 281309006122 Q-loop/lid; other site 281309006123 ABC transporter signature motif; other site 281309006124 Walker B; other site 281309006125 D-loop; other site 281309006126 H-loop/switch region; other site 281309006127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309006128 dimer interface [polypeptide binding]; other site 281309006129 conserved gate region; other site 281309006130 putative PBP binding loops; other site 281309006131 ABC-ATPase subunit interface; other site 281309006132 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 281309006133 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 281309006134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 281309006135 Protein of unknown function (DUF524); Region: DUF524; pfam04411 281309006136 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 281309006137 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 281309006138 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281309006139 Domain of unknown function DUF21; Region: DUF21; pfam01595 281309006140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281309006141 Transporter associated domain; Region: CorC_HlyC; smart01091 281309006142 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 281309006143 NAD(P) binding site [chemical binding]; other site 281309006144 catalytic residues [active] 281309006145 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 281309006146 Histidine kinase N terminal; Region: HisK_N; pfam09385 281309006147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309006148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309006149 dimer interface [polypeptide binding]; other site 281309006150 phosphorylation site [posttranslational modification] 281309006151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309006152 ATP binding site [chemical binding]; other site 281309006153 Mg2+ binding site [ion binding]; other site 281309006154 G-X-G motif; other site 281309006155 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 281309006156 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 281309006157 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309006158 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309006159 inhibitor-cofactor binding pocket; inhibition site 281309006160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309006161 catalytic residue [active] 281309006162 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 281309006163 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 281309006164 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 281309006165 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 281309006166 metal binding site [ion binding]; metal-binding site 281309006167 dimer interface [polypeptide binding]; other site 281309006168 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 281309006169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006170 Coenzyme A binding pocket [chemical binding]; other site 281309006171 PAS fold; Region: PAS_4; pfam08448 281309006172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309006173 putative active site [active] 281309006174 heme pocket [chemical binding]; other site 281309006175 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 281309006176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309006177 Walker A motif; other site 281309006178 ATP binding site [chemical binding]; other site 281309006179 Walker B motif; other site 281309006180 arginine finger; other site 281309006181 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 281309006182 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 281309006183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309006184 FeS/SAM binding site; other site 281309006185 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 281309006186 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 281309006187 toxin interface [polypeptide binding]; other site 281309006188 Zn binding site [ion binding]; other site 281309006189 hypothetical protein; Provisional; Region: PRK13672 281309006190 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 281309006191 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 281309006192 YozD-like protein; Region: YozD; pfam14162 281309006193 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281309006194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 281309006195 active site 281309006196 ATP binding site [chemical binding]; other site 281309006197 substrate binding site [chemical binding]; other site 281309006198 activation loop (A-loop); other site 281309006199 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 281309006200 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309006201 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 281309006202 active site 281309006203 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 281309006204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281309006205 catalytic residues [active] 281309006206 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281309006207 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 281309006208 DNA binding site [nucleotide binding] 281309006209 active site 281309006210 Int/Topo IB signature motif; other site 281309006211 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309006212 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 281309006213 S-layer homology domain; Region: SLH; pfam00395 281309006214 S-layer homology domain; Region: SLH; pfam00395 281309006215 S-layer homology domain; Region: SLH; pfam00395 281309006216 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 281309006217 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 281309006218 putative active site [active] 281309006219 catalytic site [active] 281309006220 Restriction endonuclease; Region: Mrr_cat; pfam04471 281309006221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309006222 non-specific DNA binding site [nucleotide binding]; other site 281309006223 salt bridge; other site 281309006224 sequence-specific DNA binding site [nucleotide binding]; other site 281309006225 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 281309006226 Replication-relaxation; Region: Replic_Relax; pfam13814 281309006227 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 281309006228 homotrimer interaction site [polypeptide binding]; other site 281309006229 putative active site [active] 281309006230 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 281309006231 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 281309006232 C1q domain; Region: C1q; cl17543 281309006233 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 281309006234 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 281309006235 YolD-like protein; Region: YolD; pfam08863 281309006236 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 281309006237 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 281309006238 Transglycosylase; Region: Transgly; pfam00912 281309006239 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281309006240 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309006241 Nucleoporin FG repeat region; Region: Nucleoporin_FG; pfam13634 281309006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309006244 putative substrate translocation pore; other site 281309006245 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 281309006246 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 281309006247 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 281309006248 dimer interface [polypeptide binding]; other site 281309006249 active site 281309006250 coenzyme A binding site [chemical binding]; other site 281309006251 citrylCoA binding site [chemical binding]; other site 281309006252 oxalacetate/citrate binding site [chemical binding]; other site 281309006253 catalytic triad [active] 281309006254 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 281309006255 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 281309006256 tetramer interface [polypeptide binding]; other site 281309006257 active site 281309006258 Mg2+/Mn2+ binding site [ion binding]; other site 281309006259 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 281309006260 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281309006261 active site 281309006262 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 281309006263 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 281309006264 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 281309006265 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 281309006266 tetrameric interface [polypeptide binding]; other site 281309006267 NAD binding site [chemical binding]; other site 281309006268 catalytic residues [active] 281309006269 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 281309006270 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 281309006271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309006272 substrate binding site [chemical binding]; other site 281309006273 oxyanion hole (OAH) forming residues; other site 281309006274 trimer interface [polypeptide binding]; other site 281309006275 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 281309006276 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 281309006277 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 281309006278 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 281309006279 active site 281309006280 metal binding site [ion binding]; metal-binding site 281309006281 DNA binding site [nucleotide binding] 281309006282 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 281309006283 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 281309006284 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 281309006285 Walker A/P-loop; other site 281309006286 ATP binding site [chemical binding]; other site 281309006287 Q-loop/lid; other site 281309006288 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 281309006289 ABC transporter signature motif; other site 281309006290 Walker B; other site 281309006291 D-loop; other site 281309006292 H-loop/switch region; other site 281309006293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309006294 Transposase domain (DUF772); Region: DUF772; pfam05598 281309006295 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309006296 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309006297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309006298 dimerization interface [polypeptide binding]; other site 281309006299 putative DNA binding site [nucleotide binding]; other site 281309006300 putative Zn2+ binding site [ion binding]; other site 281309006301 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 281309006302 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 281309006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006304 putative substrate translocation pore; other site 281309006305 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 281309006306 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 281309006307 NAD(P) binding site [chemical binding]; other site 281309006308 active site 281309006309 isochorismate synthase DhbC; Validated; Region: PRK06923 281309006310 Integrin, beta chain; Region: Integrin_beta; cl17693 281309006311 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 281309006312 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 281309006313 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 281309006314 acyl-activating enzyme (AAE) consensus motif; other site 281309006315 active site 281309006316 AMP binding site [chemical binding]; other site 281309006317 substrate binding site [chemical binding]; other site 281309006318 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 281309006319 catalytic triad [active] 281309006320 conserved cis-peptide bond; other site 281309006321 Phosphopantetheine attachment site; Region: PP-binding; cl09936 281309006322 Condensation domain; Region: Condensation; cl19241 281309006323 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 281309006324 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 281309006325 acyl-activating enzyme (AAE) consensus motif; other site 281309006326 AMP binding site [chemical binding]; other site 281309006327 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 281309006328 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 281309006329 Condensation domain; Region: Condensation; pfam00668 281309006330 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 281309006331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 281309006332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309006333 acyl-activating enzyme (AAE) consensus motif; other site 281309006334 acyl-activating enzyme (AAE) consensus motif; other site 281309006335 AMP binding site [chemical binding]; other site 281309006336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 281309006337 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 281309006338 MbtH-like protein; Region: MbtH; pfam03621 281309006339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006340 putative transporter; Provisional; Region: PRK10504 281309006341 putative substrate translocation pore; other site 281309006342 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 281309006343 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 281309006344 Chorismate lyase; Region: Chor_lyase; cl01230 281309006345 histone-like DNA-binding protein HU; Region: HU; cd13831 281309006346 dimer interface [polypeptide binding]; other site 281309006347 DNA binding site [nucleotide binding] 281309006348 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 281309006349 DinB family; Region: DinB; cl17821 281309006350 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 281309006351 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 281309006352 Subtilase family; Region: Peptidase_S8; pfam00082 281309006353 active site 281309006354 catalytic triad [active] 281309006355 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 281309006356 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 281309006357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309006358 RNA binding surface [nucleotide binding]; other site 281309006359 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 281309006360 probable active site [active] 281309006361 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 281309006362 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 281309006363 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 281309006364 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 281309006365 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 281309006366 active site 281309006367 dimer interface [polypeptide binding]; other site 281309006368 motif 1; other site 281309006369 motif 2; other site 281309006370 motif 3; other site 281309006371 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 281309006372 anticodon binding site; other site 281309006373 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309006374 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309006375 Walker A/P-loop; other site 281309006376 ATP binding site [chemical binding]; other site 281309006377 Q-loop/lid; other site 281309006378 ABC transporter signature motif; other site 281309006379 Walker B; other site 281309006380 D-loop; other site 281309006381 H-loop/switch region; other site 281309006382 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309006383 FtsX-like permease family; Region: FtsX; pfam02687 281309006384 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309006385 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309006386 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309006387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309006388 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309006389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309006390 ABC-ATPase subunit interface; other site 281309006391 ZIP Zinc transporter; Region: Zip; cl00437 281309006392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309006393 S-adenosylmethionine binding site [chemical binding]; other site 281309006394 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309006395 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 281309006396 active site 281309006397 dimerization interface [polypeptide binding]; other site 281309006398 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 281309006399 multidrug resistance protein (mdr1); Provisional; Region: PTZ00265 281309006400 Bacterial PH domain; Region: bPH_3; pfam14470 281309006401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006402 Coenzyme A binding pocket [chemical binding]; other site 281309006403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309006404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309006405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309006406 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 281309006407 Transport protein; Region: actII; TIGR00833 281309006408 MMPL family; Region: MMPL; cl14618 281309006409 MMPL family; Region: MMPL; cl14618 281309006410 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 281309006411 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 281309006412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309006413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006414 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 281309006415 Coenzyme A binding pocket [chemical binding]; other site 281309006416 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 281309006417 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 281309006418 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 281309006419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309006420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006421 Coenzyme A binding pocket [chemical binding]; other site 281309006422 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 281309006423 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 281309006424 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 281309006425 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 281309006426 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 281309006427 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 281309006428 Predicted membrane protein [Function unknown]; Region: COG2323 281309006429 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 281309006430 Predicted membrane protein [Function unknown]; Region: COG2323 281309006431 Predicted membrane protein [Function unknown]; Region: COG2323 281309006432 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 281309006433 putative active site [active] 281309006434 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309006435 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309006436 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 281309006437 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 281309006438 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309006439 active site 281309006440 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 281309006441 YodA lipocalin-like domain; Region: YodA; pfam09223 281309006442 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 281309006443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309006444 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 281309006445 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 281309006446 Ligand Binding Site [chemical binding]; other site 281309006447 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 281309006448 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 281309006449 Sulfate transporter family; Region: Sulfate_transp; pfam00916 281309006450 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 281309006451 multiple promoter invertase; Provisional; Region: mpi; PRK13413 281309006452 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 281309006453 catalytic residues [active] 281309006454 catalytic nucleophile [active] 281309006455 Presynaptic Site I dimer interface [polypeptide binding]; other site 281309006456 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 281309006457 Synaptic Flat tetramer interface [polypeptide binding]; other site 281309006458 Synaptic Site I dimer interface [polypeptide binding]; other site 281309006459 DNA binding site [nucleotide binding] 281309006460 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 281309006461 DNA-binding interface [nucleotide binding]; DNA binding site 281309006462 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309006463 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 281309006464 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 281309006465 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 281309006466 Chromate transporter; Region: Chromate_transp; pfam02417 281309006467 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 281309006468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309006469 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309006470 EamA-like transporter family; Region: EamA; pfam00892 281309006471 EamA-like transporter family; Region: EamA; pfam00892 281309006472 Cupin domain; Region: Cupin_2; pfam07883 281309006473 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309006474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309006475 protoporphyrinogen oxidase; Provisional; Region: PRK12416 281309006476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281309006477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309006478 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309006479 Cold-inducible protein YdjO; Region: YdjO; pfam14169 281309006480 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281309006481 DNA-binding site [nucleotide binding]; DNA binding site 281309006482 RNA-binding motif; other site 281309006483 CAAX protease self-immunity; Region: Abi; pfam02517 281309006484 AAA domain; Region: AAA_18; pfam13238 281309006485 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 281309006486 active site 281309006487 metal binding site [ion binding]; metal-binding site 281309006488 hypothetical protein; Provisional; Region: PRK06770 281309006489 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309006490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309006491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006492 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 281309006493 putative substrate translocation pore; other site 281309006494 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 281309006495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309006496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309006497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309006498 dimerization interface [polypeptide binding]; other site 281309006499 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 281309006500 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 281309006501 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 281309006502 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 281309006503 active site 281309006504 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 281309006505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309006506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309006507 dimerization interface [polypeptide binding]; other site 281309006508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 281309006509 MOSC domain; Region: MOSC; pfam03473 281309006510 3-alpha domain; Region: 3-alpha; pfam03475 281309006511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006512 Coenzyme A binding pocket [chemical binding]; other site 281309006513 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 281309006514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309006515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309006516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309006517 Walker A/P-loop; other site 281309006518 ATP binding site [chemical binding]; other site 281309006519 Q-loop/lid; other site 281309006520 ABC transporter signature motif; other site 281309006521 Walker B; other site 281309006522 D-loop; other site 281309006523 H-loop/switch region; other site 281309006524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309006525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309006526 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 281309006527 Walker A/P-loop; other site 281309006528 ATP binding site [chemical binding]; other site 281309006529 Q-loop/lid; other site 281309006530 ABC transporter signature motif; other site 281309006531 Walker B; other site 281309006532 D-loop; other site 281309006533 H-loop/switch region; other site 281309006534 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 281309006535 active site 281309006536 metal binding site [ion binding]; metal-binding site 281309006537 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 281309006538 LysE type translocator; Region: LysE; cl00565 281309006539 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 281309006540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309006541 non-specific DNA binding site [nucleotide binding]; other site 281309006542 salt bridge; other site 281309006543 sequence-specific DNA binding site [nucleotide binding]; other site 281309006544 Cupin domain; Region: Cupin_2; pfam07883 281309006545 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309006546 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309006547 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309006548 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 281309006549 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 281309006550 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309006551 BclB C-terminal domain; Region: exospore_TM; TIGR03721 281309006552 Cupin; Region: Cupin_1; smart00835 281309006553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281309006554 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 281309006555 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 281309006556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309006557 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281309006558 DNA binding residues [nucleotide binding] 281309006559 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309006560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309006561 S-adenosylmethionine binding site [chemical binding]; other site 281309006562 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 281309006563 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 281309006564 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 281309006565 Glycosyl hydrolase like GH101; Region: DUF187; pfam02638 281309006566 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 281309006567 active site 281309006568 P-loop; other site 281309006569 phosphorylation site [posttranslational modification] 281309006570 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 281309006571 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 281309006572 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281309006573 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 281309006574 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 281309006575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 281309006576 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 281309006577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309006578 catalytic residue [active] 281309006579 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 281309006580 tetramer interface [polypeptide binding]; other site 281309006581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309006582 catalytic residue [active] 281309006583 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 281309006584 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309006585 HNH/Endo VII superfamily toxin with a SHH signature; Region: Tox-SHH; pfam15652 281309006586 Proteins of 100 residues with WXG; Region: WXG100; cl02005 281309006587 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 281309006588 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 281309006589 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 281309006590 ATP binding site [chemical binding]; other site 281309006591 Mg++ binding site [ion binding]; other site 281309006592 motif III; other site 281309006593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309006594 nucleotide binding region [chemical binding]; other site 281309006595 ATP-binding site [chemical binding]; other site 281309006596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309006597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309006598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006599 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309006600 putative substrate translocation pore; other site 281309006601 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309006602 FtsX-like permease family; Region: FtsX; pfam02687 281309006603 FtsX-like permease family; Region: FtsX; pfam02687 281309006604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309006605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309006606 Walker A/P-loop; other site 281309006607 ATP binding site [chemical binding]; other site 281309006608 Q-loop/lid; other site 281309006609 ABC transporter signature motif; other site 281309006610 Walker B; other site 281309006611 D-loop; other site 281309006612 H-loop/switch region; other site 281309006613 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309006614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309006615 S-adenosylmethionine binding site [chemical binding]; other site 281309006616 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 281309006617 dimer interface [polypeptide binding]; other site 281309006618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309006619 S-adenosylmethionine binding site [chemical binding]; other site 281309006620 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 281309006621 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 281309006622 dimer interface [polypeptide binding]; other site 281309006623 PYR/PP interface [polypeptide binding]; other site 281309006624 TPP binding site [chemical binding]; other site 281309006625 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281309006626 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 281309006627 TPP-binding site [chemical binding]; other site 281309006628 dimer interface [polypeptide binding]; other site 281309006629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309006630 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309006631 putative DNA binding site [nucleotide binding]; other site 281309006632 putative Zn2+ binding site [ion binding]; other site 281309006633 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309006634 catalytic core [active] 281309006635 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 281309006636 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 281309006637 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 281309006638 metal binding site [ion binding]; metal-binding site 281309006639 dimer interface [polypeptide binding]; other site 281309006640 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 281309006641 active site 281309006642 catalytic triad [active] 281309006643 oxyanion hole [active] 281309006644 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 281309006645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309006646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309006647 DNA binding residues [nucleotide binding] 281309006648 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309006649 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309006650 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309006651 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309006652 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309006653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309006654 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309006655 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 281309006656 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 281309006657 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309006658 active site 281309006659 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309006660 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309006661 DNA binding site [nucleotide binding] 281309006662 domain linker motif; other site 281309006663 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 281309006664 ligand binding site [chemical binding]; other site 281309006665 dimerization interface [polypeptide binding]; other site 281309006666 polyol permease family; Region: 2A0118; TIGR00897 281309006667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006668 putative substrate translocation pore; other site 281309006669 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281309006670 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281309006671 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281309006672 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 281309006673 substrate binding site [chemical binding]; other site 281309006674 ATP binding site [chemical binding]; other site 281309006675 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 281309006676 tetrameric interface [polypeptide binding]; other site 281309006677 NAD binding site [chemical binding]; other site 281309006678 catalytic residues [active] 281309006679 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 281309006680 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 281309006681 PYR/PP interface [polypeptide binding]; other site 281309006682 dimer interface [polypeptide binding]; other site 281309006683 TPP binding site [chemical binding]; other site 281309006684 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281309006685 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 281309006686 TPP-binding site; other site 281309006687 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 281309006688 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 281309006689 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 281309006690 intersubunit interface [polypeptide binding]; other site 281309006691 active site 281309006692 zinc binding site [ion binding]; other site 281309006693 Na+ binding site [ion binding]; other site 281309006694 KduI/IolB family; Region: KduI; pfam04962 281309006695 DinB superfamily; Region: DinB_2; pfam12867 281309006696 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 281309006697 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 281309006698 active site 281309006699 metal binding site [ion binding]; metal-binding site 281309006700 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 281309006701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309006702 TPR motif; other site 281309006703 binding surface 281309006704 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309006705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309006706 salt bridge; other site 281309006707 non-specific DNA binding site [nucleotide binding]; other site 281309006708 sequence-specific DNA binding site [nucleotide binding]; other site 281309006709 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 281309006710 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 281309006711 S-layer homology domain; Region: SLH; pfam00395 281309006712 S-layer homology domain; Region: SLH; pfam00395 281309006713 S-layer homology domain; Region: SLH; pfam00395 281309006714 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 281309006715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 281309006716 active site 281309006717 metal binding site [ion binding]; metal-binding site 281309006718 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 281309006719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309006720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309006721 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309006722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309006723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309006724 PAS domain S-box; Region: sensory_box; TIGR00229 281309006725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309006726 putative active site [active] 281309006727 heme pocket [chemical binding]; other site 281309006728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309006729 metal binding site [ion binding]; metal-binding site 281309006730 active site 281309006731 I-site; other site 281309006732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309006733 Helix-turn-helix domain; Region: HTH_28; pfam13518 281309006734 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 281309006735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309006736 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 281309006737 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 281309006738 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 281309006739 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281309006740 active site residue [active] 281309006741 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 281309006742 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309006743 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 281309006744 Walker A/P-loop; other site 281309006745 ATP binding site [chemical binding]; other site 281309006746 Q-loop/lid; other site 281309006747 ABC transporter signature motif; other site 281309006748 Walker B; other site 281309006749 D-loop; other site 281309006750 H-loop/switch region; other site 281309006751 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 281309006752 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 281309006753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309006754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309006755 Protein of unknown function (DUF523); Region: DUF523; pfam04463 281309006756 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 281309006757 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281309006758 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 281309006759 FAD binding site [chemical binding]; other site 281309006760 homotetramer interface [polypeptide binding]; other site 281309006761 substrate binding pocket [chemical binding]; other site 281309006762 catalytic base [active] 281309006763 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 281309006764 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281309006765 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281309006766 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 281309006767 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 281309006768 carboxyltransferase (CT) interaction site; other site 281309006769 biotinylation site [posttranslational modification]; other site 281309006770 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 281309006771 active site 281309006772 catalytic residues [active] 281309006773 metal binding site [ion binding]; metal-binding site 281309006774 enoyl-CoA hydratase; Provisional; Region: PRK07657 281309006775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309006776 substrate binding site [chemical binding]; other site 281309006777 oxyanion hole (OAH) forming residues; other site 281309006778 trimer interface [polypeptide binding]; other site 281309006779 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 281309006780 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 281309006781 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 281309006782 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 281309006783 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 281309006784 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 281309006785 acyl-activating enzyme (AAE) consensus motif; other site 281309006786 putative AMP binding site [chemical binding]; other site 281309006787 putative active site [active] 281309006788 putative CoA binding site [chemical binding]; other site 281309006789 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309006790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006791 Coenzyme A binding pocket [chemical binding]; other site 281309006792 hypothetical protein; Provisional; Region: PRK08233 281309006793 active site 281309006794 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309006795 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309006796 DinB family; Region: DinB; cl17821 281309006797 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309006798 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309006799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309006800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309006801 dimer interface [polypeptide binding]; other site 281309006802 phosphorylation site [posttranslational modification] 281309006803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309006804 ATP binding site [chemical binding]; other site 281309006805 Mg2+ binding site [ion binding]; other site 281309006806 G-X-G motif; other site 281309006807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309006808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309006809 active site 281309006810 phosphorylation site [posttranslational modification] 281309006811 intermolecular recognition site; other site 281309006812 dimerization interface [polypeptide binding]; other site 281309006813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309006814 DNA binding site [nucleotide binding] 281309006815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309006816 Zn2+ binding site [ion binding]; other site 281309006817 Mg2+ binding site [ion binding]; other site 281309006818 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 281309006819 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 281309006820 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 281309006821 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309006822 NAD binding site [chemical binding]; other site 281309006823 substrate binding site [chemical binding]; other site 281309006824 putative active site [active] 281309006825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006826 Coenzyme A binding pocket [chemical binding]; other site 281309006827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309006828 Coenzyme A binding pocket [chemical binding]; other site 281309006829 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 281309006830 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 281309006831 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 281309006832 active site 281309006833 Zn binding site [ion binding]; other site 281309006834 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 281309006835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 281309006836 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 281309006837 putative hydrophobic ligand binding site [chemical binding]; other site 281309006838 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309006839 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309006840 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 281309006841 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 281309006842 DNA binding residues [nucleotide binding] 281309006843 drug binding residues [chemical binding]; other site 281309006844 dimer interface [polypeptide binding]; other site 281309006845 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 281309006846 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309006847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006848 putative substrate translocation pore; other site 281309006849 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 281309006850 nudix motif; other site 281309006851 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 281309006852 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 281309006853 Phosphotransferase enzyme family; Region: APH; pfam01636 281309006854 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 281309006855 active site 281309006856 substrate binding site [chemical binding]; other site 281309006857 ATP binding site [chemical binding]; other site 281309006858 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309006859 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309006860 active site 281309006861 substrate binding site [chemical binding]; other site 281309006862 Phosphotransferase enzyme family; Region: APH; pfam01636 281309006863 ATP binding site [chemical binding]; other site 281309006864 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 281309006865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309006866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309006867 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 281309006868 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 281309006869 active site 281309006870 Zn binding site [ion binding]; other site 281309006871 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 281309006872 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309006873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309006874 DNA-binding site [nucleotide binding]; DNA binding site 281309006875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309006876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309006877 homodimer interface [polypeptide binding]; other site 281309006878 catalytic residue [active] 281309006879 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 281309006880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 281309006881 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 281309006882 NAD(P) binding site [chemical binding]; other site 281309006883 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309006884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309006885 S-adenosylmethionine binding site [chemical binding]; other site 281309006886 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 281309006887 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281309006888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309006889 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309006890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309006891 S-adenosylmethionine binding site [chemical binding]; other site 281309006892 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 281309006893 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 281309006894 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 281309006895 active site 281309006896 HIGH motif; other site 281309006897 KMSKS motif; other site 281309006898 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 281309006899 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 281309006900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309006901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309006902 active site 281309006903 phosphorylation site [posttranslational modification] 281309006904 intermolecular recognition site; other site 281309006905 dimerization interface [polypeptide binding]; other site 281309006906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309006907 DNA binding site [nucleotide binding] 281309006908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309006909 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 281309006910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309006911 ATP binding site [chemical binding]; other site 281309006912 Mg2+ binding site [ion binding]; other site 281309006913 G-X-G motif; other site 281309006914 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 281309006915 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309006916 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309006917 ABC transporter; Region: ABC_tran_2; pfam12848 281309006918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309006919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309006920 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309006921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309006922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309006923 Walker A/P-loop; other site 281309006924 ATP binding site [chemical binding]; other site 281309006925 Q-loop/lid; other site 281309006926 ABC transporter signature motif; other site 281309006927 Walker B; other site 281309006928 D-loop; other site 281309006929 H-loop/switch region; other site 281309006930 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309006931 FtsX-like permease family; Region: FtsX; pfam02687 281309006932 hypothetical protein; Provisional; Region: PRK06760 281309006933 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 281309006934 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309006935 homoserine dehydrogenase; Validated; Region: PRK06813 281309006936 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 281309006937 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 281309006938 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309006939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309006940 DNA-binding site [nucleotide binding]; DNA binding site 281309006941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309006942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309006943 homodimer interface [polypeptide binding]; other site 281309006944 catalytic residue [active] 281309006945 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 281309006946 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 281309006947 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281309006948 Putative transcription activator [Transcription]; Region: TenA; COG0819 281309006949 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309006950 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 281309006951 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006952 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006953 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006954 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006955 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006956 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006957 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281309006958 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 281309006959 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 281309006960 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 281309006961 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 281309006962 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 281309006963 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 281309006964 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 281309006965 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 281309006966 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 281309006967 Protein of unknown function; Region: DUF3658; pfam12395 281309006968 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 281309006969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309006970 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309006971 putative substrate translocation pore; other site 281309006972 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 281309006973 trimer interface [polypeptide binding]; other site 281309006974 active site 281309006975 substrate binding site [chemical binding]; other site 281309006976 CoA binding site [chemical binding]; other site 281309006977 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309006978 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 281309006979 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 281309006980 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309006981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309006982 Transposase domain (DUF772); Region: DUF772; pfam05598 281309006983 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309006984 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309006985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309006986 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 281309006987 active site 281309006988 motif I; other site 281309006989 motif II; other site 281309006990 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309006991 PAS domain S-box; Region: sensory_box; TIGR00229 281309006992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309006993 putative active site [active] 281309006994 heme pocket [chemical binding]; other site 281309006995 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 281309006996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309006997 dimer interface [polypeptide binding]; other site 281309006998 phosphorylation site [posttranslational modification] 281309006999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309007000 ATP binding site [chemical binding]; other site 281309007001 Mg2+ binding site [ion binding]; other site 281309007002 G-X-G motif; other site 281309007003 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309007004 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309007005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309007006 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 281309007007 glycosyltransferase, MGT family; Region: MGT; TIGR01426 281309007008 active site 281309007009 TDP-binding site; other site 281309007010 acceptor substrate-binding pocket; other site 281309007011 homodimer interface [polypeptide binding]; other site 281309007012 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 281309007013 hypothetical protein; Provisional; Region: PRK13661 281309007014 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 281309007015 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281309007016 Walker A/P-loop; other site 281309007017 ATP binding site [chemical binding]; other site 281309007018 Q-loop/lid; other site 281309007019 ABC transporter signature motif; other site 281309007020 Walker B; other site 281309007021 D-loop; other site 281309007022 H-loop/switch region; other site 281309007023 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 281309007024 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281309007025 Walker A/P-loop; other site 281309007026 ATP binding site [chemical binding]; other site 281309007027 Q-loop/lid; other site 281309007028 ABC transporter signature motif; other site 281309007029 Walker B; other site 281309007030 D-loop; other site 281309007031 H-loop/switch region; other site 281309007032 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 281309007033 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 281309007034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309007035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309007036 dimer interface [polypeptide binding]; other site 281309007037 phosphorylation site [posttranslational modification] 281309007038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309007039 ATP binding site [chemical binding]; other site 281309007040 Mg2+ binding site [ion binding]; other site 281309007041 G-X-G motif; other site 281309007042 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 281309007043 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 281309007044 active site 281309007045 ATP binding site [chemical binding]; other site 281309007046 substrate binding site [chemical binding]; other site 281309007047 activation loop (A-loop); other site 281309007048 GrpB protein; Region: GrpB; pfam04229 281309007049 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309007050 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 281309007051 NAD(P) binding site [chemical binding]; other site 281309007052 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 281309007053 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309007054 active site 281309007055 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309007056 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309007057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309007058 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 281309007059 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 281309007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007061 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309007062 putative substrate translocation pore; other site 281309007063 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 281309007064 putative acetyltransferase; Provisional; Region: PRK03624 281309007065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007066 Coenzyme A binding pocket [chemical binding]; other site 281309007067 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 281309007068 EDD domain protein, DegV family; Region: DegV; TIGR00762 281309007069 DJ-1 family protein; Region: not_thiJ; TIGR01383 281309007070 Putative amidotransferase; Region: DUF4066; pfam13278 281309007071 conserved cys residue [active] 281309007072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281309007073 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 281309007074 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 281309007075 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309007076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 281309007077 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309007078 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 281309007079 DNA binding residues [nucleotide binding] 281309007080 putative dimer interface [polypeptide binding]; other site 281309007081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309007082 S-adenosylmethionine binding site [chemical binding]; other site 281309007083 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309007084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007085 putative substrate translocation pore; other site 281309007086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007087 Coenzyme A binding pocket [chemical binding]; other site 281309007088 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 281309007089 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 281309007090 active site 281309007091 catalytic site [active] 281309007092 metal binding site [ion binding]; metal-binding site 281309007093 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 281309007094 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309007095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309007096 DNA-binding site [nucleotide binding]; DNA binding site 281309007097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309007098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309007099 homodimer interface [polypeptide binding]; other site 281309007100 catalytic residue [active] 281309007101 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309007102 EamA-like transporter family; Region: EamA; pfam00892 281309007103 EamA-like transporter family; Region: EamA; pfam00892 281309007104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007105 Coenzyme A binding pocket [chemical binding]; other site 281309007106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 281309007107 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 281309007108 nudix motif; other site 281309007109 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 281309007110 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309007111 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 281309007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007113 putative substrate translocation pore; other site 281309007114 Cadmium resistance transporter; Region: Cad; cl19409 281309007115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007116 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309007117 Coenzyme A binding pocket [chemical binding]; other site 281309007118 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 281309007119 nudix motif; other site 281309007120 DNA polymerase III subunit beta; Validated; Region: PRK06673 281309007121 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 281309007122 putative DNA binding surface [nucleotide binding]; other site 281309007123 dimer interface [polypeptide binding]; other site 281309007124 beta-clamp/clamp loader binding surface; other site 281309007125 beta-clamp/translesion DNA polymerase binding surface; other site 281309007126 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 281309007127 putative active site [active] 281309007128 nucleotide binding site [chemical binding]; other site 281309007129 nudix motif; other site 281309007130 putative metal binding site [ion binding]; other site 281309007131 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 281309007132 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 281309007133 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 281309007134 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 281309007135 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 281309007136 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 281309007137 homotrimer interaction site [polypeptide binding]; other site 281309007138 putative active site [active] 281309007139 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 281309007140 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 281309007141 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 281309007142 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 281309007143 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 281309007144 YxiJ-like protein; Region: YxiJ; pfam14176 281309007145 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 281309007146 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 281309007147 active site 281309007148 nucleophile elbow; other site 281309007149 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 281309007150 pentamer interface [polypeptide binding]; other site 281309007151 dodecaamer interface [polypeptide binding]; other site 281309007152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007153 Coenzyme A binding pocket [chemical binding]; other site 281309007154 metal-dependent hydrolase; Provisional; Region: PRK13291 281309007155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007156 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309007157 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 281309007158 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 281309007159 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 281309007160 GIY-YIG motif/motif A; other site 281309007161 active site 281309007162 catalytic site [active] 281309007163 putative DNA binding site [nucleotide binding]; other site 281309007164 metal binding site [ion binding]; metal-binding site 281309007165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007167 Coenzyme A binding pocket [chemical binding]; other site 281309007168 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 281309007169 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 281309007170 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 281309007171 active site 281309007172 ATP binding site [chemical binding]; other site 281309007173 substrate binding site [chemical binding]; other site 281309007174 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 281309007175 nudix motif; other site 281309007176 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 281309007177 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 281309007178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309007179 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 281309007180 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 281309007181 MepB protein; Region: MepB; pfam08877 281309007182 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 281309007183 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 281309007184 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 281309007185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309007186 motif II; other site 281309007187 DinB superfamily; Region: DinB_2; pfam12867 281309007188 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 281309007189 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309007190 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 281309007191 active site 281309007192 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 281309007193 carbohydrate binding site [chemical binding]; other site 281309007194 pullulanase, type I; Region: pulA_typeI; TIGR02104 281309007195 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 281309007196 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 281309007197 Ca binding site [ion binding]; other site 281309007198 active site 281309007199 catalytic site [active] 281309007200 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 281309007201 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 281309007202 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 281309007203 active site 281309007204 Zn binding site [ion binding]; other site 281309007205 Putative zinc-finger; Region: zf-HC2; pfam13490 281309007206 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 281309007207 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 281309007208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309007209 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281309007210 DNA binding residues [nucleotide binding] 281309007211 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 281309007212 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 281309007213 SecY translocase; Region: SecY; pfam00344 281309007214 hypothetical protein; Validated; Region: PRK06672 281309007215 DnaA N-terminal domain; Region: DnaA_N; pfam11638 281309007216 DnaA N-terminal domain; Region: DnaA_N; pfam11638 281309007217 DnaA N-terminal domain; Region: DnaA_N; pfam11638 281309007218 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 281309007219 EamA-like transporter family; Region: EamA; pfam00892 281309007220 EamA-like transporter family; Region: EamA; pfam00892 281309007221 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309007222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309007223 DNA-binding site [nucleotide binding]; DNA binding site 281309007224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309007225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309007226 homodimer interface [polypeptide binding]; other site 281309007227 catalytic residue [active] 281309007228 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309007229 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309007230 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 281309007231 Mg binding site [ion binding]; other site 281309007232 nucleotide binding site [chemical binding]; other site 281309007233 putative protofilament interface [polypeptide binding]; other site 281309007234 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309007235 Predicted membrane protein [Function unknown]; Region: COG4129 281309007236 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 281309007237 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309007238 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 281309007239 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 281309007240 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 281309007241 germination protein YpeB; Region: spore_YpeB; TIGR02889 281309007242 YpeB sporulation; Region: YPEB; pfam14620 281309007243 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 281309007244 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 281309007245 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 281309007246 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 281309007247 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 281309007248 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 281309007249 Putative cyclase; Region: Cyclase; cl00814 281309007250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 281309007251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309007252 catalytic residue [active] 281309007253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309007254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309007255 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 281309007256 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 281309007257 nudix motif; other site 281309007258 N-acetyltransferase; Region: Acetyltransf_2; cl00949 281309007259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 281309007260 hydrophobic ligand binding site; other site 281309007261 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 281309007262 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 281309007263 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 281309007264 GAF domain; Region: GAF; pfam01590 281309007265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309007266 Walker A motif; other site 281309007267 ATP binding site [chemical binding]; other site 281309007268 Walker B motif; other site 281309007269 arginine finger; other site 281309007270 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 281309007271 NIPSNAP; Region: NIPSNAP; pfam07978 281309007272 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309007273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007274 Coenzyme A binding pocket [chemical binding]; other site 281309007275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309007276 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 281309007277 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 281309007278 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 281309007279 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 281309007280 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 281309007281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309007282 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309007283 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 281309007284 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 281309007285 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 281309007286 E3 interaction surface; other site 281309007287 lipoyl attachment site [posttranslational modification]; other site 281309007288 e3 binding domain; Region: E3_binding; pfam02817 281309007289 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281309007290 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 281309007291 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 281309007292 alpha subunit interface [polypeptide binding]; other site 281309007293 TPP binding site [chemical binding]; other site 281309007294 heterodimer interface [polypeptide binding]; other site 281309007295 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281309007296 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 281309007297 tetramer interface [polypeptide binding]; other site 281309007298 TPP-binding site [chemical binding]; other site 281309007299 heterodimer interface [polypeptide binding]; other site 281309007300 phosphorylation loop region [posttranslational modification] 281309007301 DinB superfamily; Region: DinB_2; pfam12867 281309007302 short chain dehydrogenase; Provisional; Region: PRK06914 281309007303 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 281309007304 NADP binding site [chemical binding]; other site 281309007305 active site 281309007306 steroid binding site; other site 281309007307 GrpB protein; Region: GrpB; pfam04229 281309007308 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 281309007309 active site 281309007310 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 281309007311 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 281309007312 nudix motif; other site 281309007313 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 281309007314 Protein phosphatase 2C; Region: PP2C_2; pfam13672 281309007315 active site 281309007316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309007317 dimer interface [polypeptide binding]; other site 281309007318 conserved gate region; other site 281309007319 putative PBP binding loops; other site 281309007320 ABC-ATPase subunit interface; other site 281309007321 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 281309007322 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 281309007323 Walker A/P-loop; other site 281309007324 ATP binding site [chemical binding]; other site 281309007325 Q-loop/lid; other site 281309007326 ABC transporter signature motif; other site 281309007327 Walker B; other site 281309007328 D-loop; other site 281309007329 H-loop/switch region; other site 281309007330 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 281309007331 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 281309007332 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 281309007333 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 281309007334 oligomer interface [polypeptide binding]; other site 281309007335 active site residues [active] 281309007336 RNA polymerase factor sigma-70; Validated; Region: PRK06704 281309007337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309007338 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281309007339 DNA binding residues [nucleotide binding] 281309007340 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 281309007341 catalytic loop [active] 281309007342 iron binding site [ion binding]; other site 281309007343 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 281309007344 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309007345 active site 281309007346 dimer interface [polypeptide binding]; other site 281309007347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007348 Coenzyme A binding pocket [chemical binding]; other site 281309007349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 281309007350 Chitin binding domain; Region: Chitin_bind_3; pfam03067 281309007351 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 281309007352 Interdomain contacts; other site 281309007353 Cytokine receptor motif; other site 281309007354 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 281309007355 Interdomain contacts; other site 281309007356 Cytokine receptor motif; other site 281309007357 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 281309007358 topology modulation protein; Reviewed; Region: PRK08118 281309007359 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 281309007360 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 281309007361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 281309007362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007363 Coenzyme A binding pocket [chemical binding]; other site 281309007364 S-layer homology domain; Region: SLH; pfam00395 281309007365 S-layer homology domain; Region: SLH; pfam00395 281309007366 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 281309007367 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 281309007368 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281309007369 active site 281309007370 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 281309007371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007372 Coenzyme A binding pocket [chemical binding]; other site 281309007373 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 281309007374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007376 Coenzyme A binding pocket [chemical binding]; other site 281309007377 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309007378 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309007379 Protein of unknown function (DUF952); Region: DUF952; pfam06108 281309007380 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 281309007381 Part of AAA domain; Region: AAA_19; pfam13245 281309007382 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 281309007383 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 281309007384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309007385 S-adenosylmethionine binding site [chemical binding]; other site 281309007386 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 281309007387 putative active site pocket [active] 281309007388 dimerization interface [polypeptide binding]; other site 281309007389 putative catalytic residue [active] 281309007390 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 281309007391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309007392 ATP binding site [chemical binding]; other site 281309007393 putative Mg++ binding site [ion binding]; other site 281309007394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309007395 nucleotide binding region [chemical binding]; other site 281309007396 ATP-binding site [chemical binding]; other site 281309007397 RQC domain; Region: RQC; pfam09382 281309007398 HRDC domain; Region: HRDC; pfam00570 281309007399 Helix-turn-helix domain; Region: HTH_40; pfam14493 281309007400 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 281309007401 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 281309007402 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 281309007403 active site 281309007404 Zn binding site [ion binding]; other site 281309007405 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 281309007406 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 281309007407 DHHA2 domain; Region: DHHA2; pfam02833 281309007408 Chitin binding domain; Region: Chitin_bind_3; pfam03067 281309007409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309007410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007411 Coenzyme A binding pocket [chemical binding]; other site 281309007412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309007413 Zn2+ binding site [ion binding]; other site 281309007414 Mg2+ binding site [ion binding]; other site 281309007415 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 281309007416 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 281309007417 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 281309007418 NAD(P) binding site [chemical binding]; other site 281309007419 catalytic residues [active] 281309007420 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 281309007421 inhibitor site; inhibition site 281309007422 active site 281309007423 dimer interface [polypeptide binding]; other site 281309007424 catalytic residue [active] 281309007425 Proline racemase; Region: Pro_racemase; pfam05544 281309007426 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 281309007427 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 281309007428 Proline racemase; Region: Pro_racemase; pfam05544 281309007429 FAD dependent oxidoreductase; Region: DAO; pfam01266 281309007430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309007431 PAS domain; Region: PAS; smart00091 281309007432 PAS domain; Region: PAS_10; pfam13596 281309007433 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 281309007434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309007435 Walker A motif; other site 281309007436 ATP binding site [chemical binding]; other site 281309007437 Walker B motif; other site 281309007438 arginine finger; other site 281309007439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 281309007440 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 281309007441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309007442 Walker A/P-loop; other site 281309007443 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 281309007444 catalytic loop [active] 281309007445 iron binding site [ion binding]; other site 281309007446 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 281309007447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309007448 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 281309007449 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 281309007450 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309007451 DinB superfamily; Region: DinB_2; pfam12867 281309007452 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 281309007453 DltD N-terminal region; Region: DltD_N; pfam04915 281309007454 DltD central region; Region: DltD_M; pfam04918 281309007455 DltD C-terminal region; Region: DltD_C; pfam04914 281309007456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007458 Coenzyme A binding pocket [chemical binding]; other site 281309007459 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309007460 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309007461 peptide binding site [polypeptide binding]; other site 281309007462 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309007463 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 281309007464 NlpC/P60 family; Region: NLPC_P60; pfam00877 281309007465 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 281309007466 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 281309007467 active site 281309007468 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 281309007469 Septum formation initiator; Region: DivIC; pfam04977 281309007470 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 281309007471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309007472 S-adenosylmethionine binding site [chemical binding]; other site 281309007473 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 281309007474 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 281309007475 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 281309007476 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 281309007477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309007478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309007479 dimerization interface [polypeptide binding]; other site 281309007480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309007481 dimer interface [polypeptide binding]; other site 281309007482 phosphorylation site [posttranslational modification] 281309007483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309007484 ATP binding site [chemical binding]; other site 281309007485 Mg2+ binding site [ion binding]; other site 281309007486 G-X-G motif; other site 281309007487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309007488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309007489 active site 281309007490 phosphorylation site [posttranslational modification] 281309007491 intermolecular recognition site; other site 281309007492 dimerization interface [polypeptide binding]; other site 281309007493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309007494 DNA binding site [nucleotide binding] 281309007495 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309007496 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 281309007497 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309007498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309007499 motif II; other site 281309007500 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 281309007501 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 281309007502 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 281309007503 Zn binding site [ion binding]; other site 281309007504 EDD domain protein, DegV family; Region: DegV; TIGR00762 281309007505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007506 Coenzyme A binding pocket [chemical binding]; other site 281309007507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309007508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309007510 putative substrate translocation pore; other site 281309007511 Protein of unknown function (DUF342); Region: DUF342; cl19219 281309007512 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 281309007513 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 281309007514 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 281309007515 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 281309007516 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 281309007517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309007519 putative substrate translocation pore; other site 281309007520 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 281309007521 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 281309007522 Predicted membrane protein [Function unknown]; Region: COG2261 281309007523 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 281309007524 active site 281309007525 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 281309007526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309007527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309007528 S-adenosylmethionine binding site [chemical binding]; other site 281309007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007530 putative substrate translocation pore; other site 281309007531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309007532 aspartate aminotransferase; Provisional; Region: PRK07681 281309007533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309007534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309007535 homodimer interface [polypeptide binding]; other site 281309007536 catalytic residue [active] 281309007537 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 281309007538 pantothenate kinase; Provisional; Region: PRK13317 281309007539 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 281309007540 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 281309007541 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 281309007542 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309007543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309007544 Walker A/P-loop; other site 281309007545 ATP binding site [chemical binding]; other site 281309007546 Q-loop/lid; other site 281309007547 ABC transporter signature motif; other site 281309007548 Walker B; other site 281309007549 D-loop; other site 281309007550 H-loop/switch region; other site 281309007551 Predicted transcriptional regulators [Transcription]; Region: COG1725 281309007552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309007553 DNA-binding site [nucleotide binding]; DNA binding site 281309007554 Protein of unknown function DUF99; Region: DUF99; cl00704 281309007555 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281309007556 HNH endonuclease; Region: HNH_5; pfam14279 281309007557 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 281309007558 active site 281309007559 dimer interface [polypeptide binding]; other site 281309007560 non-prolyl cis peptide bond; other site 281309007561 insertion regions; other site 281309007562 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 281309007563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309007564 dimer interface [polypeptide binding]; other site 281309007565 conserved gate region; other site 281309007566 putative PBP binding loops; other site 281309007567 ABC-ATPase subunit interface; other site 281309007568 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 281309007569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 281309007570 substrate binding pocket [chemical binding]; other site 281309007571 membrane-bound complex binding site; other site 281309007572 hinge residues; other site 281309007573 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 281309007574 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 281309007575 Walker A/P-loop; other site 281309007576 ATP binding site [chemical binding]; other site 281309007577 Q-loop/lid; other site 281309007578 ABC transporter signature motif; other site 281309007579 Walker B; other site 281309007580 D-loop; other site 281309007581 H-loop/switch region; other site 281309007582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309007583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309007584 Protein of unknown function (DUF402); Region: DUF402; pfam04167 281309007585 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 281309007586 nudix motif; other site 281309007587 Tetratrico peptide repeat; Region: TPR_5; pfam12688 281309007588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309007589 binding surface 281309007590 TPR motif; other site 281309007591 hypothetical protein; Provisional; Region: PRK09620 281309007592 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 281309007593 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 281309007594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007595 Coenzyme A binding pocket [chemical binding]; other site 281309007596 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 281309007597 DinB superfamily; Region: DinB_2; pfam12867 281309007598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007600 Coenzyme A binding pocket [chemical binding]; other site 281309007601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007602 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309007603 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 281309007604 active site 281309007605 NTP binding site [chemical binding]; other site 281309007606 metal binding triad [ion binding]; metal-binding site 281309007607 antibiotic binding site [chemical binding]; other site 281309007608 A new structural DNA glycosylase; Region: AlkD_like; cd06561 281309007609 active site 281309007610 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 281309007611 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 281309007612 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 281309007613 NodB motif; other site 281309007614 active site 281309007615 catalytic site [active] 281309007616 Zn binding site [ion binding]; other site 281309007617 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 281309007618 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 281309007619 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 281309007620 Sulfatase; Region: Sulfatase; pfam00884 281309007621 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 281309007622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309007623 ABC transporter; Region: ABC_tran_2; pfam12848 281309007624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309007625 hypothetical protein; Provisional; Region: PRK06761 281309007626 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 281309007627 MMPL family; Region: MMPL; cl14618 281309007628 MMPL family; Region: MMPL; cl14618 281309007629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309007630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309007631 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 281309007632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007633 Coenzyme A binding pocket [chemical binding]; other site 281309007634 Sterol carrier protein domain; Region: SCP2_2; pfam13530 281309007635 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 281309007636 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 281309007637 hinge; other site 281309007638 active site 281309007639 prephenate dehydrogenase; Validated; Region: PRK06545 281309007640 prephenate dehydrogenase; Validated; Region: PRK08507 281309007641 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 281309007642 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 281309007643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309007644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309007645 homodimer interface [polypeptide binding]; other site 281309007646 catalytic residue [active] 281309007647 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 281309007648 Tetramer interface [polypeptide binding]; other site 281309007649 active site 281309007650 FMN-binding site [chemical binding]; other site 281309007651 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 281309007652 Chorismate mutase type II; Region: CM_2; cl00693 281309007653 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 281309007654 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 281309007655 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 281309007656 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 281309007657 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 281309007658 catalytic triad [active] 281309007659 conserved cis-peptide bond; other site 281309007660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007662 Coenzyme A binding pocket [chemical binding]; other site 281309007663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309007664 YfzA-like protein; Region: YfzA; pfam14118 281309007665 hypothetical protein; Provisional; Region: PRK06762 281309007666 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 281309007667 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309007668 Bacterial SH3 domain homologues; Region: SH3b; smart00287 281309007669 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 281309007670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 281309007671 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007673 Coenzyme A binding pocket [chemical binding]; other site 281309007674 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 281309007675 enoyl-CoA hydratase; Provisional; Region: PRK06688 281309007676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309007677 substrate binding site [chemical binding]; other site 281309007678 oxyanion hole (OAH) forming residues; other site 281309007679 trimer interface [polypeptide binding]; other site 281309007680 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 281309007681 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 281309007682 acyl-activating enzyme (AAE) consensus motif; other site 281309007683 putative AMP binding site [chemical binding]; other site 281309007684 putative active site [active] 281309007685 putative CoA binding site [chemical binding]; other site 281309007686 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 281309007687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309007688 putative active site [active] 281309007689 heme pocket [chemical binding]; other site 281309007690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309007691 Walker A motif; other site 281309007692 ATP binding site [chemical binding]; other site 281309007693 Walker B motif; other site 281309007694 arginine finger; other site 281309007695 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 281309007696 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 281309007697 malate:quinone oxidoreductase; Validated; Region: PRK05257 281309007698 Predicted dehydrogenase [General function prediction only]; Region: COG0579 281309007699 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 281309007700 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 281309007701 ligand binding site [chemical binding]; other site 281309007702 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281309007703 TM-ABC transporter signature motif; other site 281309007704 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281309007705 TM-ABC transporter signature motif; other site 281309007706 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 281309007707 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281309007708 Walker A/P-loop; other site 281309007709 ATP binding site [chemical binding]; other site 281309007710 Q-loop/lid; other site 281309007711 ABC transporter signature motif; other site 281309007712 Walker B; other site 281309007713 D-loop; other site 281309007714 H-loop/switch region; other site 281309007715 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281309007716 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 281309007717 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 281309007718 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 281309007719 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 281309007720 putative N- and C-terminal domain interface [polypeptide binding]; other site 281309007721 putative active site [active] 281309007722 putative MgATP binding site [chemical binding]; other site 281309007723 catalytic site [active] 281309007724 metal binding site [ion binding]; metal-binding site 281309007725 putative carbohydrate binding site [chemical binding]; other site 281309007726 Cupin domain; Region: Cupin_2; pfam07883 281309007727 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 281309007728 putative active site; other site 281309007729 catalytic residue [active] 281309007730 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007731 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309007732 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 281309007733 active site 281309007734 NTP binding site [chemical binding]; other site 281309007735 metal binding triad [ion binding]; metal-binding site 281309007736 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 281309007737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007738 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309007739 putative substrate translocation pore; other site 281309007740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309007741 dimerization interface [polypeptide binding]; other site 281309007742 putative DNA binding site [nucleotide binding]; other site 281309007743 putative Zn2+ binding site [ion binding]; other site 281309007744 DinB superfamily; Region: DinB_2; pfam12867 281309007745 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309007746 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309007747 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309007748 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 281309007749 putative catalytic cysteine [active] 281309007750 gamma-glutamyl kinase; Provisional; Region: PRK05429 281309007751 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 281309007752 nucleotide binding site [chemical binding]; other site 281309007753 homotetrameric interface [polypeptide binding]; other site 281309007754 putative phosphate binding site [ion binding]; other site 281309007755 putative allosteric binding site; other site 281309007756 PUA domain; Region: PUA; pfam01472 281309007757 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 281309007758 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 281309007759 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 281309007760 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 281309007761 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 281309007762 putative metal binding site [ion binding]; other site 281309007763 putative dimer interface [polypeptide binding]; other site 281309007764 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 281309007765 Transcriptional regulator [Transcription]; Region: IclR; COG1414 281309007766 Bacterial transcriptional regulator; Region: IclR; pfam01614 281309007767 S-methylmethionine transporter; Provisional; Region: PRK11387 281309007768 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309007769 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 281309007770 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 281309007771 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 281309007772 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 281309007773 putative di-iron ligands [ion binding]; other site 281309007774 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 281309007775 active site 281309007776 dimer interface [polypeptide binding]; other site 281309007777 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 281309007778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309007779 salt bridge; other site 281309007780 non-specific DNA binding site [nucleotide binding]; other site 281309007781 sequence-specific DNA binding site [nucleotide binding]; other site 281309007782 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 281309007783 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 281309007784 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 281309007785 Protein of unknown function (DUF973); Region: DUF973; pfam06157 281309007786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309007787 ATP binding site [chemical binding]; other site 281309007788 Mg2+ binding site [ion binding]; other site 281309007789 G-X-G motif; other site 281309007790 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 281309007791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 281309007792 active site 281309007793 phosphorylation site [posttranslational modification] 281309007794 intermolecular recognition site; other site 281309007795 dimerization interface [polypeptide binding]; other site 281309007796 LytTr DNA-binding domain; Region: LytTR; pfam04397 281309007797 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 281309007798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309007799 motif II; other site 281309007800 uridine kinase; Provisional; Region: PRK07667 281309007801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309007804 Coenzyme A binding pocket [chemical binding]; other site 281309007805 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 281309007806 active site 281309007807 metal binding site [ion binding]; metal-binding site 281309007808 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 281309007809 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309007810 MoxR-like ATPases [General function prediction only]; Region: COG0714 281309007811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309007812 Walker A motif; other site 281309007813 ATP binding site [chemical binding]; other site 281309007814 Walker B motif; other site 281309007815 arginine finger; other site 281309007816 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 281309007817 Protein of unknown function DUF58; Region: DUF58; pfam01882 281309007818 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 281309007819 proline/glycine betaine transporter; Provisional; Region: PRK10642 281309007820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309007821 putative substrate translocation pore; other site 281309007822 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 281309007823 active site 281309007824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309007825 active site 281309007826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281309007827 active site 281309007828 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 281309007829 Ligand binding site; other site 281309007830 Putative Catalytic site; other site 281309007831 DXD motif; other site 281309007832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309007833 active site 281309007834 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 281309007835 Ligand binding site; other site 281309007836 Putative Catalytic site; other site 281309007837 DXD motif; other site 281309007838 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309007839 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309007840 inhibitor-cofactor binding pocket; inhibition site 281309007841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309007842 catalytic residue [active] 281309007843 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 281309007844 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 281309007845 tetramer interface [polypeptide binding]; other site 281309007846 heme binding pocket [chemical binding]; other site 281309007847 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 281309007848 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 281309007849 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 281309007850 active site 281309007851 LysE type translocator; Region: LysE; cl00565 281309007852 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309007853 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 281309007854 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 281309007855 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 281309007856 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 281309007857 Protein of unknown function DUF58; Region: DUF58; pfam01882 281309007858 MoxR-like ATPases [General function prediction only]; Region: COG0714 281309007859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309007860 Walker A motif; other site 281309007861 ATP binding site [chemical binding]; other site 281309007862 Walker B motif; other site 281309007863 arginine finger; other site 281309007864 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 281309007865 Putative toxin 64; Region: Toxin_64; pfam15542 281309007866 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 281309007867 HNH/Endo VII superfamily toxin with a SHH signature; Region: Tox-SHH; pfam15652 281309007868 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 281309007869 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 281309007870 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 281309007871 Immunity protein Imm3; Region: Imm3; pfam14425 281309007872 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 281309007873 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 281309007874 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 281309007875 LXG domain of WXG superfamily; Region: LXG; pfam04740 281309007876 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 281309007877 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 281309007878 Uncharacterized conserved protein [Function unknown]; Region: COG1359 281309007879 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 281309007880 dimer interface [polypeptide binding]; other site 281309007881 FMN binding site [chemical binding]; other site 281309007882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309007883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309007884 putative DNA binding site [nucleotide binding]; other site 281309007885 putative Zn2+ binding site [ion binding]; other site 281309007886 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 281309007887 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 281309007888 G1 box; other site 281309007889 putative GEF interaction site [polypeptide binding]; other site 281309007890 GTP/Mg2+ binding site [chemical binding]; other site 281309007891 Switch I region; other site 281309007892 G2 box; other site 281309007893 G3 box; other site 281309007894 Switch II region; other site 281309007895 G4 box; other site 281309007896 G5 box; other site 281309007897 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 281309007898 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 281309007899 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 281309007900 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 281309007901 nudix motif; other site 281309007902 YfzA-like protein; Region: YfzA; pfam14118 281309007903 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 281309007904 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309007905 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309007906 Walker A/P-loop; other site 281309007907 ATP binding site [chemical binding]; other site 281309007908 Q-loop/lid; other site 281309007909 ABC transporter signature motif; other site 281309007910 Walker B; other site 281309007911 D-loop; other site 281309007912 H-loop/switch region; other site 281309007913 Predicted transcriptional regulators [Transcription]; Region: COG1725 281309007914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309007915 DNA-binding site [nucleotide binding]; DNA binding site 281309007916 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309007917 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 281309007918 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 281309007919 putative NAD(P) binding site [chemical binding]; other site 281309007920 active site 281309007921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309007922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309007923 Walker A/P-loop; other site 281309007924 ATP binding site [chemical binding]; other site 281309007925 Q-loop/lid; other site 281309007926 ABC transporter signature motif; other site 281309007927 Walker B; other site 281309007928 D-loop; other site 281309007929 H-loop/switch region; other site 281309007930 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309007931 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309007932 FtsX-like permease family; Region: FtsX; pfam02687 281309007933 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309007934 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309007935 FtsX-like permease family; Region: FtsX; pfam02687 281309007936 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 281309007937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309007938 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 281309007939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309007940 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 281309007941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309007942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007943 Coenzyme A binding pocket [chemical binding]; other site 281309007944 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 281309007945 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 281309007946 nudix motif; other site 281309007947 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309007948 EamA-like transporter family; Region: EamA; pfam00892 281309007949 EamA-like transporter family; Region: EamA; pfam00892 281309007950 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309007951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309007952 DNA-binding site [nucleotide binding]; DNA binding site 281309007953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309007954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309007955 homodimer interface [polypeptide binding]; other site 281309007956 catalytic residue [active] 281309007957 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 281309007958 hypothetical protein; Validated; Region: PRK00124 281309007959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309007960 HAMP domain; Region: HAMP; pfam00672 281309007961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309007962 dimer interface [polypeptide binding]; other site 281309007963 phosphorylation site [posttranslational modification] 281309007964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309007965 ATP binding site [chemical binding]; other site 281309007966 Mg2+ binding site [ion binding]; other site 281309007967 G-X-G motif; other site 281309007968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309007969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309007970 active site 281309007971 phosphorylation site [posttranslational modification] 281309007972 intermolecular recognition site; other site 281309007973 dimerization interface [polypeptide binding]; other site 281309007974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 281309007975 DNA binding site [nucleotide binding] 281309007976 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309007977 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 281309007978 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 281309007979 uridine kinase; Validated; Region: PRK06696 281309007980 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 281309007981 active site 281309007982 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 281309007983 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 281309007984 active site 281309007985 metal binding site [ion binding]; metal-binding site 281309007986 Phosphotransferase enzyme family; Region: APH; pfam01636 281309007987 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309007988 active site 281309007989 substrate binding site [chemical binding]; other site 281309007990 ATP binding site [chemical binding]; other site 281309007991 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 281309007992 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 281309007993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309007994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309007995 Coenzyme A binding pocket [chemical binding]; other site 281309007996 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309007997 lysine transporter; Provisional; Region: PRK10836 281309007998 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 281309007999 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 281309008000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309008001 S-adenosylmethionine binding site [chemical binding]; other site 281309008002 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 281309008003 putative active site [active] 281309008004 nucleotide binding site [chemical binding]; other site 281309008005 nudix motif; other site 281309008006 putative metal binding site [ion binding]; other site 281309008007 Cephalosporin hydroxylase; Region: CmcI; pfam04989 281309008008 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 281309008009 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281309008010 Catalytic site [active] 281309008011 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 281309008012 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309008013 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309008014 Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922 281309008015 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309008016 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 281309008017 NAD+ binding site [chemical binding]; other site 281309008018 substrate binding site [chemical binding]; other site 281309008019 Zn binding site [ion binding]; other site 281309008020 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 281309008021 putative substrate binding pocket [chemical binding]; other site 281309008022 AC domain interface; other site 281309008023 catalytic triad [active] 281309008024 AB domain interface; other site 281309008025 interchain disulfide; other site 281309008026 Protein of unknown function (DUF979); Region: DUF979; pfam06166 281309008027 Protein of unknown function (DUF969); Region: DUF969; pfam06149 281309008028 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 281309008029 putative active site [active] 281309008030 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 281309008031 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 281309008032 Transcriptional regulator [Transcription]; Region: IclR; COG1414 281309008033 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 281309008034 Bacterial transcriptional regulator; Region: IclR; pfam01614 281309008035 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 281309008036 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281309008037 Catalytic site [active] 281309008038 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 281309008039 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 281309008040 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 281309008041 stage II sporulation protein P; Region: spore_II_P; TIGR02867 281309008042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008043 dimerization interface [polypeptide binding]; other site 281309008044 putative DNA binding site [nucleotide binding]; other site 281309008045 putative Zn2+ binding site [ion binding]; other site 281309008046 DinB superfamily; Region: DinB_2; pfam12867 281309008047 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281309008048 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 281309008049 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 281309008050 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 281309008051 putative active site [active] 281309008052 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309008053 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309008054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 281309008055 Nucleoside recognition; Region: Gate; pfam07670 281309008056 Transposase; Region: HTH_Tnp_1; cl17663 281309008057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309008058 HTH-like domain; Region: HTH_21; pfam13276 281309008059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 281309008060 Integrase core domain; Region: rve; pfam00665 281309008061 Integrase core domain; Region: rve_2; pfam13333 281309008062 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 281309008063 Phosphotransferase enzyme family; Region: APH; pfam01636 281309008064 putative active site [active] 281309008065 putative substrate binding site [chemical binding]; other site 281309008066 ATP binding site [chemical binding]; other site 281309008067 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309008068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008069 Coenzyme A binding pocket [chemical binding]; other site 281309008070 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 281309008071 Ferritin-like domain; Region: Ferritin; pfam00210 281309008072 dinuclear metal binding motif [ion binding]; other site 281309008073 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 281309008074 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 281309008075 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 281309008076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309008077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309008078 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 281309008079 phosphoenolpyruvate synthase; Validated; Region: PRK06241 281309008080 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 281309008081 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 281309008082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309008083 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 281309008084 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 281309008085 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 281309008086 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 281309008087 LysE type translocator; Region: LysE; cl00565 281309008088 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 281309008089 Spore germination protein; Region: Spore_permease; cl17796 281309008090 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309008091 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 281309008092 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 281309008093 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309008094 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 281309008095 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 281309008096 NAD binding site [chemical binding]; other site 281309008097 catalytic Zn binding site [ion binding]; other site 281309008098 structural Zn binding site [ion binding]; other site 281309008099 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 281309008100 dimanganese center [ion binding]; other site 281309008101 aspartate ammonia-lyase; Provisional; Region: PRK14515 281309008102 Aspartase; Region: Aspartase; cd01357 281309008103 active sites [active] 281309008104 tetramer interface [polypeptide binding]; other site 281309008105 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 281309008106 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 281309008107 active site 281309008108 homodimer interface [polypeptide binding]; other site 281309008109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309008110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309008111 non-specific DNA binding site [nucleotide binding]; other site 281309008112 salt bridge; other site 281309008113 sequence-specific DNA binding site [nucleotide binding]; other site 281309008114 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 281309008115 Spore germination protein; Region: Spore_permease; cl17796 281309008116 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309008117 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 281309008118 PAS domain S-box; Region: sensory_box; TIGR00229 281309008119 PAS domain S-box; Region: sensory_box; TIGR00229 281309008120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309008121 putative active site [active] 281309008122 heme pocket [chemical binding]; other site 281309008123 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 281309008124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309008125 putative active site [active] 281309008126 heme pocket [chemical binding]; other site 281309008127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309008128 dimer interface [polypeptide binding]; other site 281309008129 phosphorylation site [posttranslational modification] 281309008130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309008131 ATP binding site [chemical binding]; other site 281309008132 Mg2+ binding site [ion binding]; other site 281309008133 G-X-G motif; other site 281309008134 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309008135 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309008136 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309008137 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 281309008138 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 281309008139 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 281309008140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309008141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309008142 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309008143 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 281309008144 GIY-YIG motif/motif A; other site 281309008145 active site 281309008146 catalytic site [active] 281309008147 metal binding site [ion binding]; metal-binding site 281309008148 amino acid transporter; Region: 2A0306; TIGR00909 281309008149 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309008150 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 281309008151 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 281309008152 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 281309008153 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 281309008154 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 281309008155 DoxX-like family; Region: DoxX_2; pfam13564 281309008156 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 281309008157 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 281309008158 Spore germination protein; Region: Spore_permease; pfam03845 281309008159 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309008160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309008161 active site 281309008162 phosphorylation site [posttranslational modification] 281309008163 intermolecular recognition site; other site 281309008164 dimerization interface [polypeptide binding]; other site 281309008165 YcbB domain; Region: YcbB; pfam08664 281309008166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309008167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309008168 ATP binding site [chemical binding]; other site 281309008169 Mg2+ binding site [ion binding]; other site 281309008170 G-X-G motif; other site 281309008171 glutaminase; Reviewed; Region: PRK12357 281309008172 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 281309008173 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 281309008174 transmembrane helices; other site 281309008175 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 281309008176 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 281309008177 active site 281309008178 active site 281309008179 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 281309008180 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 281309008181 putative active site [active] 281309008182 putative metal binding site [ion binding]; other site 281309008183 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 281309008184 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 281309008185 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 281309008186 tetramer interface [polypeptide binding]; other site 281309008187 heme binding pocket [chemical binding]; other site 281309008188 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309008189 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309008190 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309008191 TAP-like protein; Region: Abhydrolase_4; pfam08386 281309008192 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 281309008193 catalytic triad [active] 281309008194 dimer interface [polypeptide binding]; other site 281309008195 conserved cis-peptide bond; other site 281309008196 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 281309008197 catalytic triad [active] 281309008198 dimer interface [polypeptide binding]; other site 281309008199 conserved cis-peptide bond; other site 281309008200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 281309008201 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 281309008202 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 281309008203 active site 281309008204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309008205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309008206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309008207 dimerization interface [polypeptide binding]; other site 281309008208 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 281309008209 Cl binding site [ion binding]; other site 281309008210 oligomer interface [polypeptide binding]; other site 281309008211 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 281309008212 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 281309008213 Mg binding site [ion binding]; other site 281309008214 nucleotide binding site [chemical binding]; other site 281309008215 putative protofilament interface [polypeptide binding]; other site 281309008216 Heat induced stress protein YflT; Region: YflT; pfam11181 281309008217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309008218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309008219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309008220 dimerization interface [polypeptide binding]; other site 281309008221 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309008222 EamA-like transporter family; Region: EamA; pfam00892 281309008223 EamA-like transporter family; Region: EamA; pfam00892 281309008224 Predicted transcriptional regulator [Transcription]; Region: COG2378 281309008225 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 281309008226 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 281309008227 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 281309008228 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 281309008229 TspO/MBR family; Region: TspO_MBR; pfam03073 281309008230 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 281309008231 DNA photolyase; Region: DNA_photolyase; pfam00875 281309008232 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 281309008233 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 281309008234 zinc binding site [ion binding]; other site 281309008235 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; cl19828 281309008236 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 281309008237 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 281309008238 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 281309008239 Protein of unknown function DUF58; Region: DUF58; pfam01882 281309008240 MoxR-like ATPases [General function prediction only]; Region: COG0714 281309008241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309008242 Walker A motif; other site 281309008243 ATP binding site [chemical binding]; other site 281309008244 Walker B motif; other site 281309008245 arginine finger; other site 281309008246 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 281309008247 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309008248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309008249 Walker A/P-loop; other site 281309008250 ATP binding site [chemical binding]; other site 281309008251 Q-loop/lid; other site 281309008252 ABC transporter signature motif; other site 281309008253 Walker B; other site 281309008254 D-loop; other site 281309008255 H-loop/switch region; other site 281309008256 Methylamine utilisation protein MauE; Region: MauE; pfam07291 281309008257 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 281309008258 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 281309008259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309008260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008261 Coenzyme A binding pocket [chemical binding]; other site 281309008262 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 281309008263 putative active site [active] 281309008264 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 281309008265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309008266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008267 putative substrate translocation pore; other site 281309008268 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 281309008269 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 281309008270 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 281309008271 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309008272 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309008273 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 281309008274 B12 binding site [chemical binding]; other site 281309008275 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 281309008276 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 281309008277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309008278 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309008279 Walker A/P-loop; other site 281309008280 ATP binding site [chemical binding]; other site 281309008281 Q-loop/lid; other site 281309008282 ABC transporter signature motif; other site 281309008283 Walker B; other site 281309008284 D-loop; other site 281309008285 H-loop/switch region; other site 281309008286 FtsX-like permease family; Region: FtsX; pfam02687 281309008287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309008288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309008289 ATP binding site [chemical binding]; other site 281309008290 Mg2+ binding site [ion binding]; other site 281309008291 G-X-G motif; other site 281309008292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309008294 active site 281309008295 phosphorylation site [posttranslational modification] 281309008296 intermolecular recognition site; other site 281309008297 dimerization interface [polypeptide binding]; other site 281309008298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309008299 DNA binding residues [nucleotide binding] 281309008300 dimerization interface [polypeptide binding]; other site 281309008301 Phosphotransferase enzyme family; Region: APH; pfam01636 281309008302 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309008303 active site 281309008304 ATP binding site [chemical binding]; other site 281309008305 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 281309008306 Low molecular weight phosphatase family; Region: LMWPc; cd00115 281309008307 active site 281309008308 arsenical-resistance protein; Region: acr3; TIGR00832 281309008309 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 281309008310 putative metal binding site [ion binding]; other site 281309008311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008312 dimerization interface [polypeptide binding]; other site 281309008313 putative DNA binding site [nucleotide binding]; other site 281309008314 putative Zn2+ binding site [ion binding]; other site 281309008315 DinB superfamily; Region: DinB_2; pfam12867 281309008316 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309008317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008318 Coenzyme A binding pocket [chemical binding]; other site 281309008319 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 281309008320 Male sterility protein; Region: NAD_binding_4; pfam07993 281309008321 putative NAD(P) binding site [chemical binding]; other site 281309008322 active site 281309008323 putative substrate binding site [chemical binding]; other site 281309008324 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309008325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309008326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309008327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309008328 short chain dehydrogenase; Provisional; Region: PRK12746 281309008329 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 281309008330 NAD(P) binding site [chemical binding]; other site 281309008331 active site 281309008332 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 281309008333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008334 putative DNA binding site [nucleotide binding]; other site 281309008335 putative Zn2+ binding site [ion binding]; other site 281309008336 AsnC family; Region: AsnC_trans_reg; pfam01037 281309008337 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309008338 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 281309008339 metal binding site [ion binding]; metal-binding site 281309008340 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 281309008341 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309008342 AAA domain; Region: AAA_11; pfam13086 281309008343 Part of AAA domain; Region: AAA_19; pfam13245 281309008344 Erp protein C-terminus; Region: Erp_C; pfam06780 281309008345 AAA domain; Region: AAA_30; pfam13604 281309008346 AAA domain; Region: AAA_12; pfam13087 281309008347 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 281309008348 putative active site [active] 281309008349 catalytic site [active] 281309008350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 281309008351 active site 281309008352 metal binding site [ion binding]; metal-binding site 281309008353 putative monooxygenase; Provisional; Region: PRK11118 281309008354 DoxX-like family; Region: DoxX_2; pfam13564 281309008355 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309008356 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309008357 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 281309008358 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 281309008359 Flavodoxin; Region: Flavodoxin_1; pfam00258 281309008360 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 281309008361 FAD binding pocket [chemical binding]; other site 281309008362 FAD binding motif [chemical binding]; other site 281309008363 catalytic residues [active] 281309008364 NAD binding pocket [chemical binding]; other site 281309008365 phosphate binding motif [ion binding]; other site 281309008366 beta-alpha-beta structure motif; other site 281309008367 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 281309008368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008369 putative substrate translocation pore; other site 281309008370 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 281309008371 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 281309008372 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309008373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008374 putative substrate translocation pore; other site 281309008375 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 281309008376 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 281309008377 D-cysteine desulfhydrase; Validated; Region: PRK03910 281309008378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309008379 catalytic residue [active] 281309008380 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 281309008381 HTH-like domain; Region: HTH_21; pfam13276 281309008382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 281309008383 Integrase core domain; Region: rve; pfam00665 281309008384 Integrase core domain; Region: rve_2; pfam13333 281309008385 Transposase; Region: HTH_Tnp_1; cl17663 281309008386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309008387 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 281309008388 active site 281309008389 metal binding site [ion binding]; metal-binding site 281309008390 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309008391 Protein of unknown function (DUF998); Region: DUF998; pfam06197 281309008392 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 281309008393 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309008394 active site 281309008395 CoA binding site [chemical binding]; other site 281309008396 AMP binding site [chemical binding]; other site 281309008397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 281309008398 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309008399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309008400 NAD(P) binding site [chemical binding]; other site 281309008401 active site 281309008402 hypothetical protein; Provisional; Region: PRK06849 281309008403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309008404 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281309008405 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 281309008406 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 281309008407 dimer interface [polypeptide binding]; other site 281309008408 active site 281309008409 CoA binding pocket [chemical binding]; other site 281309008410 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 281309008411 AAA domain; Region: AAA_33; pfam13671 281309008412 AAA domain; Region: AAA_18; pfam13238 281309008413 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 281309008414 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 281309008415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309008416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309008417 Walker A/P-loop; other site 281309008418 ATP binding site [chemical binding]; other site 281309008419 Q-loop/lid; other site 281309008420 ABC transporter signature motif; other site 281309008421 Walker B; other site 281309008422 D-loop; other site 281309008423 H-loop/switch region; other site 281309008424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309008425 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309008426 FtsX-like permease family; Region: FtsX; pfam02687 281309008427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008428 dimerization interface [polypeptide binding]; other site 281309008429 putative DNA binding site [nucleotide binding]; other site 281309008430 Predicted transcriptional regulator [Transcription]; Region: COG2345 281309008431 putative Zn2+ binding site [ion binding]; other site 281309008432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008433 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309008434 putative substrate translocation pore; other site 281309008435 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 281309008436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309008437 dimerization interface [polypeptide binding]; other site 281309008438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309008439 dimer interface [polypeptide binding]; other site 281309008440 phosphorylation site [posttranslational modification] 281309008441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309008442 ATP binding site [chemical binding]; other site 281309008443 Mg2+ binding site [ion binding]; other site 281309008444 G-X-G motif; other site 281309008445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309008446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309008447 active site 281309008448 phosphorylation site [posttranslational modification] 281309008449 intermolecular recognition site; other site 281309008450 dimerization interface [polypeptide binding]; other site 281309008451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309008452 DNA binding site [nucleotide binding] 281309008453 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309008454 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309008455 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309008456 2TM domain; Region: 2TM; pfam13239 281309008457 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 281309008458 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 281309008459 putative dimer interface [polypeptide binding]; other site 281309008460 catalytic triad [active] 281309008461 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 281309008462 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 281309008463 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 281309008464 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 281309008465 putative ligand binding site [chemical binding]; other site 281309008466 putative NAD binding site [chemical binding]; other site 281309008467 putative catalytic site [active] 281309008468 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 281309008469 L-serine binding site [chemical binding]; other site 281309008470 ACT domain interface; other site 281309008471 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 281309008472 homodimer interface [polypeptide binding]; other site 281309008473 substrate-cofactor binding pocket; other site 281309008474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309008475 catalytic residue [active] 281309008476 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 281309008477 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 281309008478 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 281309008479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309008480 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281309008481 DNA binding residues [nucleotide binding] 281309008482 Domain of unknown function (DUF378); Region: DUF378; cl00943 281309008483 Cupin domain; Region: Cupin_2; cl17218 281309008484 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 281309008485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309008486 Penicillin amidase; Region: Penicil_amidase; pfam01804 281309008487 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 281309008488 active site 281309008489 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 281309008490 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 281309008491 amidase catalytic site [active] 281309008492 Zn binding residues [ion binding]; other site 281309008493 substrate binding site [chemical binding]; other site 281309008494 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309008495 S-layer homology domain; Region: SLH; pfam00395 281309008496 S-layer homology domain; Region: SLH; pfam00395 281309008497 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 281309008498 Protein of unknown function, DUF600; Region: DUF600; pfam04634 281309008499 A new structural DNA glycosylase; Region: AlkD_like; cd06561 281309008500 active site 281309008501 Immunity protein 27; Region: Imm27; pfam15573 281309008502 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309008503 Immunity protein Imm3; Region: Imm3; pfam14425 281309008504 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 281309008505 Immunity protein 16; Region: Imm16; pfam15565 281309008506 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309008507 Immunity protein 16; Region: Imm16; pfam15565 281309008508 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 281309008509 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309008510 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 281309008511 Protein of unknown function, DUF600; Region: DUF600; pfam04634 281309008512 TIP41-like family; Region: TIP41; pfam04176 281309008513 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 281309008514 Syd protein (SUKH-2); Region: Syd; pfam07348 281309008515 HNH/Endo VII superfamily nuclease toxin with a HHH motif; Region: Tox-HNH-HHH; pfam15637 281309008516 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 281309008517 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 281309008518 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309008519 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 281309008520 Nuclease N terminal; Region: Nuc_N; pfam14448 281309008521 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 281309008522 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 281309008523 Active_site [active] 281309008524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 281309008525 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 281309008526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 281309008527 Transposase; Region: DEDD_Tnp_IS110; pfam01548 281309008528 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 281309008529 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281309008530 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 281309008531 catalytic residues [active] 281309008532 catalytic nucleophile [active] 281309008533 Recombinase; Region: Recombinase; pfam07508 281309008534 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 281309008535 Nuclease N terminal; Region: Nuc_N; pfam14448 281309008536 Protein of unknown function, DUF600; Region: DUF600; pfam04634 281309008537 Nuclease N terminal; Region: Nuc_N; pfam14448 281309008538 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 281309008539 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 281309008540 Protein of unknown function, DUF600; Region: DUF600; pfam04634 281309008541 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 281309008542 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 281309008543 S-layer homology domain; Region: SLH; pfam00395 281309008544 S-layer homology domain; Region: SLH; pfam00395 281309008545 S-layer homology domain; Region: SLH; pfam00395 281309008546 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 281309008547 putative metal binding site [ion binding]; other site 281309008548 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 281309008549 NETI protein; Region: NETI; pfam14044 281309008550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309008552 putative substrate translocation pore; other site 281309008553 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309008554 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309008555 TAP-like protein; Region: Abhydrolase_4; pfam08386 281309008556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309008557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309008558 putative DNA binding site [nucleotide binding]; other site 281309008559 putative Zn2+ binding site [ion binding]; other site 281309008560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309008562 putative substrate translocation pore; other site 281309008563 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 281309008564 Acyltransferase family; Region: Acyl_transf_3; cl19154 281309008565 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 281309008566 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309008567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309008568 Walker A/P-loop; other site 281309008569 ATP binding site [chemical binding]; other site 281309008570 Q-loop/lid; other site 281309008571 ABC transporter signature motif; other site 281309008572 Walker B; other site 281309008573 D-loop; other site 281309008574 H-loop/switch region; other site 281309008575 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 281309008576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008577 putative DNA binding site [nucleotide binding]; other site 281309008578 putative Zn2+ binding site [ion binding]; other site 281309008579 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 281309008580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309008581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309008582 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 281309008583 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 281309008584 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 281309008585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309008586 SWIM zinc finger; Region: SWIM; pfam04434 281309008587 YwiC-like protein; Region: YwiC; pfam14256 281309008588 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 281309008589 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281309008590 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281309008591 Walker A/P-loop; other site 281309008592 ATP binding site [chemical binding]; other site 281309008593 Q-loop/lid; other site 281309008594 ABC transporter signature motif; other site 281309008595 Walker B; other site 281309008596 D-loop; other site 281309008597 H-loop/switch region; other site 281309008598 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281309008599 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 281309008600 Walker A/P-loop; other site 281309008601 ATP binding site [chemical binding]; other site 281309008602 Q-loop/lid; other site 281309008603 ABC transporter signature motif; other site 281309008604 Walker B; other site 281309008605 D-loop; other site 281309008606 H-loop/switch region; other site 281309008607 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 281309008608 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 281309008609 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 281309008610 Calreticulin family; Region: Calreticulin; pfam00262 281309008611 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 281309008612 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 281309008613 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 281309008614 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 281309008615 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 281309008616 amidase catalytic site [active] 281309008617 Zn binding residues [ion binding]; other site 281309008618 substrate binding site [chemical binding]; other site 281309008619 S-layer homology domain; Region: SLH; pfam00395 281309008620 S-layer homology domain; Region: SLH; pfam00395 281309008621 S-layer homology domain; Region: SLH; pfam00395 281309008622 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309008623 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309008624 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 281309008625 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309008626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309008627 non-specific DNA binding site [nucleotide binding]; other site 281309008628 salt bridge; other site 281309008629 sequence-specific DNA binding site [nucleotide binding]; other site 281309008630 Protein of unknown function (DUF975); Region: DUF975; cl10504 281309008631 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 281309008632 putative deacylase active site [active] 281309008633 histidyl-tRNA synthetase; Provisional; Region: PRK12420 281309008634 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 281309008635 dimer interface [polypeptide binding]; other site 281309008636 motif 1; other site 281309008637 active site 281309008638 motif 2; other site 281309008639 motif 3; other site 281309008640 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 281309008641 anticodon binding site; other site 281309008642 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 281309008643 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 281309008644 dimer interface [polypeptide binding]; other site 281309008645 FMN binding site [chemical binding]; other site 281309008646 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 281309008647 pyruvate kinase; Validated; Region: PRK06739 281309008648 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 281309008649 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 281309008650 classical (c) SDRs; Region: SDR_c; cd05233 281309008651 NAD(P) binding site [chemical binding]; other site 281309008652 active site 281309008653 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 281309008654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309008655 Walker A/P-loop; other site 281309008656 ATP binding site [chemical binding]; other site 281309008657 Q-loop/lid; other site 281309008658 ABC transporter signature motif; other site 281309008659 Walker B; other site 281309008660 D-loop; other site 281309008661 H-loop/switch region; other site 281309008662 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 281309008663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309008664 non-specific DNA binding site [nucleotide binding]; other site 281309008665 salt bridge; other site 281309008666 sequence-specific DNA binding site [nucleotide binding]; other site 281309008667 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 281309008668 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 281309008669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309008670 motif II; other site 281309008671 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 281309008672 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 281309008673 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 281309008674 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 281309008675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008676 Coenzyme A binding pocket [chemical binding]; other site 281309008677 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 281309008678 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 281309008679 nudix motif; other site 281309008680 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 281309008681 putative metal binding site [ion binding]; other site 281309008682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281309008683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309008684 maltose O-acetyltransferase; Provisional; Region: PRK10092 281309008685 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 281309008686 active site 281309008687 substrate binding site [chemical binding]; other site 281309008688 trimer interface [polypeptide binding]; other site 281309008689 CoA binding site [chemical binding]; other site 281309008690 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309008691 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 281309008692 FtsX-like permease family; Region: FtsX; pfam02687 281309008693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309008694 FtsX-like permease family; Region: FtsX; pfam02687 281309008695 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309008696 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309008697 Walker A/P-loop; other site 281309008698 ATP binding site [chemical binding]; other site 281309008699 Q-loop/lid; other site 281309008700 ABC transporter signature motif; other site 281309008701 Walker B; other site 281309008702 D-loop; other site 281309008703 H-loop/switch region; other site 281309008704 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 281309008705 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 281309008706 active site 281309008707 HIGH motif; other site 281309008708 dimer interface [polypeptide binding]; other site 281309008709 KMSKS motif; other site 281309008710 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 281309008711 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 281309008712 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 281309008713 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 281309008714 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281309008715 Predicted membrane protein [Function unknown]; Region: COG2261 281309008716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309008718 Coenzyme A binding pocket [chemical binding]; other site 281309008719 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 281309008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 281309008721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309008722 S-adenosylmethionine binding site [chemical binding]; other site 281309008723 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 281309008724 CGNR zinc finger; Region: zf-CGNR; pfam11706 281309008725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008726 multidrug resistance protein MdtH; Provisional; Region: PRK11646 281309008727 putative substrate translocation pore; other site 281309008728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309008729 TPR motif; other site 281309008730 TPR repeat; Region: TPR_11; pfam13414 281309008731 binding surface 281309008732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309008733 binding surface 281309008734 Tetratricopeptide repeat; Region: TPR_16; pfam13432 281309008735 TPR motif; other site 281309008736 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 281309008737 hypothetical protein; Provisional; Region: PRK04164 281309008738 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 281309008739 ATP synthase I chain; Region: ATP_synt_I; pfam03899 281309008740 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281309008741 Domain of unknown function DUF21; Region: DUF21; pfam01595 281309008742 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281309008743 Transporter associated domain; Region: CorC_HlyC; smart01091 281309008744 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 281309008745 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309008746 DNA binding residues [nucleotide binding] 281309008747 putative dimer interface [polypeptide binding]; other site 281309008748 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309008749 EamA-like transporter family; Region: EamA; pfam00892 281309008750 EamA-like transporter family; Region: EamA; pfam00892 281309008751 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 281309008752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 281309008753 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 281309008754 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 281309008755 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 281309008756 N- and C-terminal domain interface [polypeptide binding]; other site 281309008757 active site 281309008758 catalytic site [active] 281309008759 metal binding site [ion binding]; metal-binding site 281309008760 carbohydrate binding site [chemical binding]; other site 281309008761 ATP binding site [chemical binding]; other site 281309008762 GntP family permease; Region: GntP_permease; pfam02447 281309008763 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281309008764 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 281309008765 active site 281309008766 intersubunit interactions; other site 281309008767 catalytic residue [active] 281309008768 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 281309008769 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 281309008770 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 281309008771 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 281309008772 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 281309008773 TPP-binding site [chemical binding]; other site 281309008774 dimer interface [polypeptide binding]; other site 281309008775 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 281309008776 PYR/PP interface [polypeptide binding]; other site 281309008777 dimer interface [polypeptide binding]; other site 281309008778 TPP binding site [chemical binding]; other site 281309008779 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281309008780 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 281309008781 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 281309008782 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 281309008783 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 281309008784 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 281309008785 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309008786 putative NAD(P) binding site [chemical binding]; other site 281309008787 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 281309008788 classical (c) SDRs; Region: SDR_c; cd05233 281309008789 NAD(P) binding site [chemical binding]; other site 281309008790 active site 281309008791 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 281309008792 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 281309008793 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 281309008794 active site 281309008795 Zn binding site [ion binding]; other site 281309008796 Peptidase M60-like family; Region: M60-like; cl19940 281309008797 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 281309008798 dimer interface [polypeptide binding]; other site 281309008799 FMN binding site [chemical binding]; other site 281309008800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309008801 active site 281309008802 hypothetical protein; Provisional; Region: PRK02487 281309008803 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 281309008804 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 281309008805 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 281309008806 IDEAL domain; Region: IDEAL; pfam08858 281309008807 Predicted transcriptional regulator [Transcription]; Region: COG1959 281309008808 Rrf2 family protein; Region: rrf2_super; TIGR00738 281309008809 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 281309008810 putative catalytic residues [active] 281309008811 thiol/disulfide switch; other site 281309008812 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 281309008813 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 281309008814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309008815 DNA-binding site [nucleotide binding]; DNA binding site 281309008816 UTRA domain; Region: UTRA; pfam07702 281309008817 putative oxidoreductase; Provisional; Region: PRK10206 281309008818 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281309008819 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281309008820 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 281309008821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309008822 S-adenosylmethionine binding site [chemical binding]; other site 281309008823 Predicted transcriptional regulators [Transcription]; Region: COG1733 281309008824 dimerization interface [polypeptide binding]; other site 281309008825 putative DNA binding site [nucleotide binding]; other site 281309008826 putative Zn2+ binding site [ion binding]; other site 281309008827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008828 dimerization interface [polypeptide binding]; other site 281309008829 putative DNA binding site [nucleotide binding]; other site 281309008830 putative Zn2+ binding site [ion binding]; other site 281309008831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309008832 active site 281309008833 catalytic tetrad [active] 281309008834 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 281309008835 putative hydrophobic ligand binding site [chemical binding]; other site 281309008836 protein interface [polypeptide binding]; other site 281309008837 gate; other site 281309008838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309008839 Phosphotransferase enzyme family; Region: APH; pfam01636 281309008840 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309008841 active site 281309008842 substrate binding site [chemical binding]; other site 281309008843 ATP binding site [chemical binding]; other site 281309008844 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 281309008845 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 281309008846 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 281309008847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008848 Coenzyme A binding pocket [chemical binding]; other site 281309008849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309008850 short chain dehydrogenase; Region: adh_short; pfam00106 281309008851 NAD(P) binding site [chemical binding]; other site 281309008852 active site 281309008853 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309008854 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309008855 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 281309008856 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309008857 acyl-activating enzyme (AAE) consensus motif; other site 281309008858 AMP binding site [chemical binding]; other site 281309008859 active site 281309008860 CoA binding site [chemical binding]; other site 281309008861 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 281309008862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008863 dimerization interface [polypeptide binding]; other site 281309008864 putative DNA binding site [nucleotide binding]; other site 281309008865 putative Zn2+ binding site [ion binding]; other site 281309008866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309008867 dimerization interface [polypeptide binding]; other site 281309008868 putative DNA binding site [nucleotide binding]; other site 281309008869 putative Zn2+ binding site [ion binding]; other site 281309008870 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 281309008871 active site 281309008872 Glyco_18 domain; Region: Glyco_18; smart00636 281309008873 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 281309008874 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 281309008875 NodB motif; other site 281309008876 putative active site [active] 281309008877 putative catalytic site [active] 281309008878 putative Zn binding site [ion binding]; other site 281309008879 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 281309008880 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 281309008881 DXD motif; other site 281309008882 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 281309008883 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 281309008884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309008885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309008886 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 281309008887 active site 281309008888 hypothetical protein; Provisional; Region: PRK12856 281309008889 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 281309008890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309008891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309008892 Integron-associated effector binding protein; Region: Cass2; pfam14526 281309008893 Predicted transcriptional regulator [Transcription]; Region: COG2378 281309008894 HTH domain; Region: HTH_11; pfam08279 281309008895 WYL domain; Region: WYL; pfam13280 281309008896 Protein of unknown function (DUF805); Region: DUF805; pfam05656 281309008897 ABC-2 type transporter; Region: ABC2_membrane; cl17235 281309008898 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 281309008899 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 281309008900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309008901 Walker A/P-loop; other site 281309008902 ATP binding site [chemical binding]; other site 281309008903 Q-loop/lid; other site 281309008904 ABC transporter signature motif; other site 281309008905 Walker B; other site 281309008906 D-loop; other site 281309008907 H-loop/switch region; other site 281309008908 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 281309008909 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309008910 hydroxylamine reductase; Provisional; Region: PRK12310 281309008911 ACS interaction site; other site 281309008912 CODH interaction site; other site 281309008913 metal cluster binding site [ion binding]; other site 281309008914 Developmental protein; Region: Ashwin; pfam15323 281309008915 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309008916 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 281309008917 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281309008918 active site 281309008919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 281309008920 metal binding site [ion binding]; metal-binding site 281309008921 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 281309008922 hypothetical protein; Provisional; Region: PRK06771 281309008923 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309008924 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 281309008925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 281309008926 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 281309008927 dimer interface [polypeptide binding]; other site 281309008928 ligand binding site [chemical binding]; other site 281309008929 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 281309008930 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 281309008931 ligand binding site [chemical binding]; other site 281309008932 flexible hinge region; other site 281309008933 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 281309008934 Protein of unknown function, DUF606; Region: DUF606; pfam04657 281309008935 Protein of unknown function, DUF606; Region: DUF606; pfam04657 281309008936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309008937 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 281309008938 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 281309008939 putative NAD(P) binding site [chemical binding]; other site 281309008940 dimer interface [polypeptide binding]; other site 281309008941 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 281309008942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309008943 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 281309008944 putative substrate translocation pore; other site 281309008945 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 281309008946 Haemolysin XhlA; Region: XhlA; pfam10779 281309008947 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 281309008948 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 281309008949 Citrate transporter; Region: CitMHS; pfam03600 281309008950 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 281309008951 transmembrane helices; other site 281309008952 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 281309008953 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309008954 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 281309008955 putative ligand binding residues [chemical binding]; other site 281309008956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309008957 ABC-ATPase subunit interface; other site 281309008958 dimer interface [polypeptide binding]; other site 281309008959 putative PBP binding regions; other site 281309008960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309008961 ABC-ATPase subunit interface; other site 281309008962 dimer interface [polypeptide binding]; other site 281309008963 putative PBP binding regions; other site 281309008964 Protein of unknown function (DUF817); Region: DUF817; pfam05675 281309008965 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 281309008966 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 281309008967 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 281309008968 DinB superfamily; Region: DinB_2; pfam12867 281309008969 DinB family; Region: DinB; cl17821 281309008970 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 281309008971 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 281309008972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309008973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309008974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309008975 dimerization interface [polypeptide binding]; other site 281309008976 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309008977 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 281309008978 NADP binding site [chemical binding]; other site 281309008979 dimer interface [polypeptide binding]; other site 281309008980 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309008981 catalytic core [active] 281309008982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309008983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309008984 Coenzyme A binding pocket [chemical binding]; other site 281309008985 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 281309008986 MutS domain III; Region: MutS_III; pfam05192 281309008987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309008988 Walker A/P-loop; other site 281309008989 ATP binding site [chemical binding]; other site 281309008990 Q-loop/lid; other site 281309008991 ABC transporter signature motif; other site 281309008992 Walker B; other site 281309008993 D-loop; other site 281309008994 H-loop/switch region; other site 281309008995 Sporozoite P67 surface antigen; Region: Sporozoite_P67; pfam05642 281309008996 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 281309008997 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 281309008998 active site 281309008999 Na/Ca binding site [ion binding]; other site 281309009000 catalytic site [active] 281309009001 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 281309009002 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 281309009003 oligoendopeptidase F; Region: pepF; TIGR00181 281309009004 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 281309009005 active site 281309009006 Zn binding site [ion binding]; other site 281309009007 Beta-lactamase; Region: Beta-lactamase; pfam00144 281309009008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309009009 putative substrate translocation pore; other site 281309009010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309009011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309009012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309009013 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 281309009014 putative dimerization interface [polypeptide binding]; other site 281309009015 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 281309009016 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 281309009017 putative active site [active] 281309009018 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 281309009019 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 281309009020 active site 281309009021 catalytic site [active] 281309009022 metal binding site [ion binding]; metal-binding site 281309009023 hypothetical protein; Provisional; Region: PRK06126 281309009024 FAD binding domain; Region: FAD_binding_3; pfam01494 281309009025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309009026 dimerization interface [polypeptide binding]; other site 281309009027 putative DNA binding site [nucleotide binding]; other site 281309009028 putative Zn2+ binding site [ion binding]; other site 281309009029 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281309009030 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 281309009031 putative NAD(P) binding site [chemical binding]; other site 281309009032 hypothetical protein; Validated; Region: PRK00029 281309009033 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 281309009034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309009035 TPR motif; other site 281309009036 binding surface 281309009037 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 281309009038 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 281309009039 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 281309009040 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 281309009041 FAD binding domain; Region: FAD_binding_4; pfam01565 281309009042 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 281309009043 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 281309009044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281309009045 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 281309009046 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 281309009047 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 281309009048 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 281309009049 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 281309009050 trimer interface [polypeptide binding]; other site 281309009051 active site 281309009052 substrate binding site [chemical binding]; other site 281309009053 CoA binding site [chemical binding]; other site 281309009054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 281309009055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309009056 catalytic residue [active] 281309009057 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 281309009058 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309009059 active site 281309009060 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281309009061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281309009062 active site 281309009063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309009064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 281309009065 enoyl-CoA hydratase; Provisional; Region: PRK06688 281309009066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309009067 substrate binding site [chemical binding]; other site 281309009068 oxyanion hole (OAH) forming residues; other site 281309009069 trimer interface [polypeptide binding]; other site 281309009070 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 281309009071 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 281309009072 FOG: PKD repeat [General function prediction only]; Region: COG3291 281309009073 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 281309009074 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 281309009075 MgtC family; Region: MgtC; pfam02308 281309009076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309009077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309009078 Coenzyme A binding pocket [chemical binding]; other site 281309009079 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 281309009080 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 281309009081 putative metal binding site [ion binding]; other site 281309009082 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 281309009083 active site 281309009084 metal binding site [ion binding]; metal-binding site 281309009085 VanW like protein; Region: VanW; pfam04294 281309009086 DASH complex subunit Spc34; Region: DASH_Spc34; pfam08657 281309009087 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 281309009088 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 281309009089 Pleckstrin homology-like domain; Region: PH-like; cl17171 281309009090 exonuclease; Provisional; Region: PRK06722 281309009091 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 281309009092 active site 281309009093 catalytic site [active] 281309009094 substrate binding site [chemical binding]; other site 281309009095 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281309009096 DNA-binding site [nucleotide binding]; DNA binding site 281309009097 RNA-binding motif; other site 281309009098 flavodoxin; Provisional; Region: PRK06703 281309009099 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 281309009100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 281309009101 nudix motif; other site 281309009102 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 281309009103 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 281309009104 trimer interface [polypeptide binding]; other site 281309009105 active site 281309009106 substrate binding site [chemical binding]; other site 281309009107 CoA binding site [chemical binding]; other site 281309009108 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009109 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009110 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009111 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009112 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009113 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009114 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009115 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009116 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009117 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009118 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009119 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009120 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009121 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009122 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009123 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009124 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 281309009125 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 281309009126 NADP binding site [chemical binding]; other site 281309009127 homodimer interface [polypeptide binding]; other site 281309009128 active site 281309009129 Predicted acetyltransferase [General function prediction only]; Region: COG3393 281309009130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309009131 argininosuccinate lyase; Provisional; Region: PRK06705 281309009132 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 281309009133 active sites [active] 281309009134 tetramer interface [polypeptide binding]; other site 281309009135 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309009136 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309009137 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 281309009138 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 281309009139 active site 281309009140 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 281309009141 Na binding site [ion binding]; other site 281309009142 Protein of unknown function (DUF997); Region: DUF997; pfam06196 281309009143 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 281309009144 NAD(P) binding site [chemical binding]; other site 281309009145 catalytic residues [active] 281309009146 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 281309009147 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 281309009148 NAD(P) binding site [chemical binding]; other site 281309009149 homotetramer interface [polypeptide binding]; other site 281309009150 homodimer interface [polypeptide binding]; other site 281309009151 active site 281309009152 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 281309009153 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 281309009154 Divergent PAP2 family; Region: DUF212; pfam02681 281309009155 Predicted permeases [General function prediction only]; Region: RarD; COG2962 281309009156 EamA-like transporter family; Region: EamA; pfam00892 281309009157 EamA-like transporter family; Region: EamA; pfam00892 281309009158 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 281309009159 antiporter inner membrane protein; Provisional; Region: PRK11670 281309009160 Domain of unknown function DUF59; Region: DUF59; pfam01883 281309009161 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 281309009162 Walker A motif; other site 281309009163 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 281309009164 MoaE interaction surface [polypeptide binding]; other site 281309009165 MoeB interaction surface [polypeptide binding]; other site 281309009166 thiocarboxylated glycine; other site 281309009167 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 281309009168 MoaE homodimer interface [polypeptide binding]; other site 281309009169 MoaD interaction [polypeptide binding]; other site 281309009170 active site residues [active] 281309009171 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 281309009172 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 281309009173 dimer interface [polypeptide binding]; other site 281309009174 putative functional site; other site 281309009175 putative MPT binding site; other site 281309009176 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 281309009177 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 281309009178 ATP binding site [chemical binding]; other site 281309009179 substrate interface [chemical binding]; other site 281309009180 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 281309009181 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 281309009182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309009183 FeS/SAM binding site; other site 281309009184 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 281309009185 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 281309009186 Uncharacterized conserved protein [Function unknown]; Region: COG5609 281309009187 Uncharacterized conserved protein [Function unknown]; Region: COG2427 281309009188 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 281309009189 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 281309009190 catalytic loop [active] 281309009191 iron binding site [ion binding]; other site 281309009192 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 281309009193 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 281309009194 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 281309009195 [4Fe-4S] binding site [ion binding]; other site 281309009196 molybdopterin cofactor binding site; other site 281309009197 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 281309009198 molybdopterin cofactor binding site; other site 281309009199 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309009200 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 281309009201 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 281309009202 Tubulin like; Region: Tubulin_2; pfam13809 281309009203 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 281309009204 metal ion-dependent adhesion site (MIDAS); other site 281309009205 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309009206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309009207 S-adenosylmethionine binding site [chemical binding]; other site 281309009208 O-methyltransferase; Region: Methyltransf_2; pfam00891 281309009209 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309009210 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309009211 peptide binding site [polypeptide binding]; other site 281309009212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309009213 Helix-turn-helix domain; Region: HTH_28; pfam13518 281309009214 Helix-turn-helix domain; Region: HTH_28; pfam13518 281309009215 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; pfam05812 281309009216 HTH-like domain; Region: HTH_21; pfam13276 281309009217 Integrase core domain; Region: rve; pfam00665 281309009218 Integrase core domain; Region: rve_2; pfam13333 281309009219 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309009220 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309009221 peptide binding site [polypeptide binding]; other site 281309009222 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309009223 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309009224 peptide binding site [polypeptide binding]; other site 281309009225 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 281309009226 Transcriptional regulator [Transcription]; Region: LytR; COG1316 281309009227 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 281309009228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309009229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309009230 DNA binding residues [nucleotide binding] 281309009231 Acyltransferase family; Region: Acyl_transf_3; cl19154 281309009232 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309009233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309009234 Walker A/P-loop; other site 281309009235 ATP binding site [chemical binding]; other site 281309009236 Q-loop/lid; other site 281309009237 ABC transporter signature motif; other site 281309009238 Walker B; other site 281309009239 D-loop; other site 281309009240 H-loop/switch region; other site 281309009241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309009242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309009243 putative oxidoreductase; Provisional; Region: PRK11579 281309009244 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281309009245 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281309009246 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 281309009247 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 281309009248 CAP-like domain; other site 281309009249 active site 281309009250 primary dimer interface [polypeptide binding]; other site 281309009251 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309009252 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309009253 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309009254 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281309009255 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 281309009256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309009257 ATP binding site [chemical binding]; other site 281309009258 Mg2+ binding site [ion binding]; other site 281309009259 G-X-G motif; other site 281309009260 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 281309009261 anchoring element; other site 281309009262 dimer interface [polypeptide binding]; other site 281309009263 ATP binding site [chemical binding]; other site 281309009264 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 281309009265 active site 281309009266 metal binding site [ion binding]; metal-binding site 281309009267 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 281309009268 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 281309009269 Trypsin; Region: Trypsin; pfam00089 281309009270 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 281309009271 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 281309009272 protein binding site [polypeptide binding]; other site 281309009273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309009274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309009275 active site 281309009276 phosphorylation site [posttranslational modification] 281309009277 intermolecular recognition site; other site 281309009278 dimerization interface [polypeptide binding]; other site 281309009279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309009280 DNA binding site [nucleotide binding] 281309009281 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 281309009282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309009283 FeS/SAM binding site; other site 281309009284 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 281309009285 Class III ribonucleotide reductase; Region: RNR_III; cd01675 281309009286 effector binding site; other site 281309009287 active site 281309009288 Zn binding site [ion binding]; other site 281309009289 glycine loop; other site 281309009290 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 281309009291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 281309009292 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 281309009293 active site 281309009294 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 281309009295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309009296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309009297 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 281309009298 active site 281309009299 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 281309009300 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 281309009301 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 281309009302 active site 281309009303 catalytic site [active] 281309009304 substrate binding site [chemical binding]; other site 281309009305 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 281309009306 catalytic residues [active] 281309009307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309009308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309009309 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281309009310 Walker A/P-loop; other site 281309009311 ATP binding site [chemical binding]; other site 281309009312 ABC transporter signature motif; other site 281309009313 Walker B; other site 281309009314 D-loop; other site 281309009315 H-loop/switch region; other site 281309009316 aconitate hydratase; Validated; Region: PRK09277 281309009317 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 281309009318 substrate binding site [chemical binding]; other site 281309009319 ligand binding site [chemical binding]; other site 281309009320 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 281309009321 substrate binding site [chemical binding]; other site 281309009322 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309009323 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 281309009324 NodB motif; other site 281309009325 active site 281309009326 catalytic site [active] 281309009327 metal binding site [ion binding]; metal-binding site 281309009328 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 281309009329 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 281309009330 putative dimer interface [polypeptide binding]; other site 281309009331 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 281309009332 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 281309009333 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 281309009334 DHHA1 domain; Region: DHHA1; pfam02272 281309009335 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 281309009336 nudix motif; other site 281309009337 SAP domain; Region: SAP; pfam02037 281309009338 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 281309009339 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 281309009340 dimer interface [polypeptide binding]; other site 281309009341 active site 281309009342 acyl-CoA synthetase; Validated; Region: PRK07638 281309009343 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309009344 acyl-activating enzyme (AAE) consensus motif; other site 281309009345 AMP binding site [chemical binding]; other site 281309009346 active site 281309009347 CoA binding site [chemical binding]; other site 281309009348 BioY family; Region: BioY; pfam02632 281309009349 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 281309009350 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 281309009351 dimer interface [polypeptide binding]; other site 281309009352 acyl-activating enzyme (AAE) consensus motif; other site 281309009353 putative active site [active] 281309009354 AMP binding site [chemical binding]; other site 281309009355 putative CoA binding site [chemical binding]; other site 281309009356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309009357 Coenzyme A binding pocket [chemical binding]; other site 281309009358 CsbD-like; Region: CsbD; pfam05532 281309009359 S-layer homology domain; Region: SLH; pfam00395 281309009360 S-layer homology domain; Region: SLH; pfam00395 281309009361 S-layer homology domain; Region: SLH; pfam00395 281309009362 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 281309009363 active site 281309009364 catalytic motif [active] 281309009365 Zn binding site [ion binding]; other site 281309009366 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 281309009367 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 281309009368 amidase catalytic site [active] 281309009369 Zn binding residues [ion binding]; other site 281309009370 substrate binding site [chemical binding]; other site 281309009371 active site 281309009372 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 281309009373 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309009374 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309009375 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309009376 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 281309009377 dimer interface [polypeptide binding]; other site 281309009378 putative metal binding site [ion binding]; other site 281309009379 PAS domain S-box; Region: sensory_box; TIGR00229 281309009380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309009381 putative active site [active] 281309009382 heme pocket [chemical binding]; other site 281309009383 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 281309009384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309009385 putative active site [active] 281309009386 heme pocket [chemical binding]; other site 281309009387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309009388 dimer interface [polypeptide binding]; other site 281309009389 phosphorylation site [posttranslational modification] 281309009390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309009391 ATP binding site [chemical binding]; other site 281309009392 Mg2+ binding site [ion binding]; other site 281309009393 G-X-G motif; other site 281309009394 Predicted esterase [General function prediction only]; Region: COG0400 281309009395 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 281309009396 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 281309009397 Zn binding site [ion binding]; other site 281309009398 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 281309009399 Zn binding site [ion binding]; other site 281309009400 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 281309009401 Na binding site [ion binding]; other site 281309009402 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 281309009403 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 281309009404 active site 281309009405 FMN binding site [chemical binding]; other site 281309009406 substrate binding site [chemical binding]; other site 281309009407 3Fe-4S cluster binding site [ion binding]; other site 281309009408 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 281309009409 FMN binding site [chemical binding]; other site 281309009410 active site 281309009411 substrate binding site [chemical binding]; other site 281309009412 catalytic residue [active] 281309009413 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309009414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309009415 Transposase domain (DUF772); Region: DUF772; pfam05598 281309009416 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309009417 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 281309009418 Agmatinase-like family; Region: Agmatinase-like; cd09990 281309009419 active site 281309009420 oligomer interface [polypeptide binding]; other site 281309009421 Mn binding site [ion binding]; other site 281309009422 imidazolonepropionase; Validated; Region: PRK09356 281309009423 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 281309009424 active site 281309009425 urocanate hydratase; Provisional; Region: PRK05414 281309009426 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 281309009427 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 281309009428 active sites [active] 281309009429 tetramer interface [polypeptide binding]; other site 281309009430 anti-terminator HutP; Provisional; Region: hutP; PRK03065 281309009431 hexamer interface [polypeptide binding]; other site 281309009432 RNA binding site [nucleotide binding]; other site 281309009433 Histidine-zinc binding site [chemical binding]; other site 281309009434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309009435 S-adenosylmethionine binding site [chemical binding]; other site 281309009436 DJ-1 family protein; Region: not_thiJ; TIGR01383 281309009437 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 281309009438 conserved cys residue [active] 281309009439 AAA domain; Region: AAA_28; pfam13521 281309009440 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 281309009441 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009442 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009443 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009444 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009445 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009446 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009447 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009448 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009449 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009450 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009451 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 281309009452 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009453 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009454 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009455 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009456 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009457 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309009458 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009459 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009460 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009461 conserved repeat domain; Region: B_ant_repeat; TIGR01451 281309009462 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 281309009463 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 281309009464 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309009465 EamA-like transporter family; Region: EamA; pfam00892 281309009466 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 281309009467 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309009468 metal binding site [ion binding]; metal-binding site 281309009469 dimer interface [polypeptide binding]; other site 281309009470 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 281309009471 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309009472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309009473 Walker A/P-loop; other site 281309009474 ATP binding site [chemical binding]; other site 281309009475 Q-loop/lid; other site 281309009476 ABC transporter signature motif; other site 281309009477 Walker B; other site 281309009478 D-loop; other site 281309009479 H-loop/switch region; other site 281309009480 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 281309009481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309009482 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 281309009483 putative dimerization interface [polypeptide binding]; other site 281309009484 putative substrate binding pocket [chemical binding]; other site 281309009485 holin-like protein; Validated; Region: PRK01658 281309009486 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 281309009487 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 281309009488 nudix motif; other site 281309009489 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 281309009490 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 281309009491 Nuclease-related domain; Region: NERD; pfam08378 281309009492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309009493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309009494 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 281309009495 Walker A/P-loop; other site 281309009496 ATP binding site [chemical binding]; other site 281309009497 Q-loop/lid; other site 281309009498 ABC transporter signature motif; other site 281309009499 Walker B; other site 281309009500 D-loop; other site 281309009501 H-loop/switch region; other site 281309009502 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309009503 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 281309009504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309009505 Walker A/P-loop; other site 281309009506 ATP binding site [chemical binding]; other site 281309009507 Q-loop/lid; other site 281309009508 ABC transporter signature motif; other site 281309009509 Walker B; other site 281309009510 D-loop; other site 281309009511 H-loop/switch region; other site 281309009512 hypothetical protein; Provisional; Region: PRK01844 281309009513 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 281309009514 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 281309009515 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 281309009516 TPP-binding site [chemical binding]; other site 281309009517 dimer interface [polypeptide binding]; other site 281309009518 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 281309009519 PYR/PP interface [polypeptide binding]; other site 281309009520 dimer interface [polypeptide binding]; other site 281309009521 TPP binding site [chemical binding]; other site 281309009522 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281309009523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309009524 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 281309009525 Probable transposase; Region: OrfB_IS605; pfam01385 281309009526 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309009527 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 281309009528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309009529 dimer interface [polypeptide binding]; other site 281309009530 conserved gate region; other site 281309009531 putative PBP binding loops; other site 281309009532 ABC-ATPase subunit interface; other site 281309009533 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 281309009534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309009535 dimer interface [polypeptide binding]; other site 281309009536 conserved gate region; other site 281309009537 putative PBP binding loops; other site 281309009538 ABC-ATPase subunit interface; other site 281309009539 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 281309009540 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 281309009541 Walker A/P-loop; other site 281309009542 ATP binding site [chemical binding]; other site 281309009543 Q-loop/lid; other site 281309009544 ABC transporter signature motif; other site 281309009545 Walker B; other site 281309009546 D-loop; other site 281309009547 H-loop/switch region; other site 281309009548 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 281309009549 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 281309009550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 281309009551 membrane-bound complex binding site; other site 281309009552 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 281309009553 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 281309009554 active site 281309009555 metal binding site [ion binding]; metal-binding site 281309009556 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 281309009557 hypothetical protein; Provisional; Region: PRK01546 281309009558 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281309009559 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 281309009560 catalytic residues [active] 281309009561 catalytic nucleophile [active] 281309009562 LexA repressor; Validated; Region: PRK00215 281309009563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309009564 putative DNA binding site [nucleotide binding]; other site 281309009565 putative Zn2+ binding site [ion binding]; other site 281309009566 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 281309009567 Catalytic site [active] 281309009568 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 281309009569 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 281309009570 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 281309009571 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309009572 glutamine synthetase, type I; Region: GlnA; TIGR00653 281309009573 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 281309009574 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 281309009575 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 281309009576 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309009577 DNA binding residues [nucleotide binding] 281309009578 putative dimer interface [polypeptide binding]; other site 281309009579 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 281309009580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309009581 catalytic residue [active] 281309009582 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 281309009583 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 281309009584 HflX GTPase family; Region: HflX; cd01878 281309009585 G1 box; other site 281309009586 GTP/Mg2+ binding site [chemical binding]; other site 281309009587 Switch I region; other site 281309009588 G2 box; other site 281309009589 G3 box; other site 281309009590 Switch II region; other site 281309009591 G4 box; other site 281309009592 G5 box; other site 281309009593 Predicted membrane protein [Function unknown]; Region: COG2860 281309009594 UPF0126 domain; Region: UPF0126; pfam03458 281309009595 UPF0126 domain; Region: UPF0126; pfam03458 281309009596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309009597 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 281309009598 Walker A motif; other site 281309009599 ATP binding site [chemical binding]; other site 281309009600 Walker B motif; other site 281309009601 arginine finger; other site 281309009602 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 281309009603 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281309009604 active site 281309009605 catalytic residues [active] 281309009606 DNA binding site [nucleotide binding] 281309009607 Int/Topo IB signature motif; other site 281309009608 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009609 High molecular weight glutenin subunit; Region: Glutenin_hmw; pfam03157 281309009610 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009611 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009612 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009613 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009614 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009615 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009616 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009617 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009618 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009619 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009620 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009621 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009622 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309009623 bacterial Hfq-like; Region: Hfq; cd01716 281309009624 hexamer interface [polypeptide binding]; other site 281309009625 Sm1 motif; other site 281309009626 RNA binding site [nucleotide binding]; other site 281309009627 Sm2 motif; other site 281309009628 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 281309009629 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309009630 Bacterial SH3 domain homologues; Region: SH3b; smart00287 281309009631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 281309009632 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 281309009633 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 281309009634 active site 281309009635 phosphorylation site [posttranslational modification] 281309009636 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 281309009637 active site 281309009638 P-loop; other site 281309009639 phosphorylation site [posttranslational modification] 281309009640 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 281309009641 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 281309009642 putative substrate binding site [chemical binding]; other site 281309009643 putative ATP binding site [chemical binding]; other site 281309009644 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 281309009645 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 281309009646 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 281309009647 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 281309009648 dimer interface [polypeptide binding]; other site 281309009649 active site 281309009650 metal binding site [ion binding]; metal-binding site 281309009651 Predicted membrane protein [Function unknown]; Region: COG2322 281309009652 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 281309009653 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 281309009654 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 281309009655 Glyco_18 domain; Region: Glyco_18; smart00636 281309009656 putative active site [active] 281309009657 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 281309009658 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 281309009659 putative active site [active] 281309009660 putative metal binding site [ion binding]; other site 281309009661 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 281309009662 histone-like DNA-binding protein HU; Region: HU; cd13831 281309009663 dimer interface [polypeptide binding]; other site 281309009664 DNA binding site [nucleotide binding] 281309009665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281309009666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309009667 Coenzyme A binding pocket [chemical binding]; other site 281309009668 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281309009669 metal-binding site [ion binding] 281309009670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 281309009671 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281309009672 metal-binding site [ion binding] 281309009673 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309009674 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 281309009675 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281309009676 metal-binding site [ion binding] 281309009677 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 281309009678 putative homodimer interface [polypeptide binding]; other site 281309009679 putative homotetramer interface [polypeptide binding]; other site 281309009680 putative allosteric switch controlling residues; other site 281309009681 putative metal binding site [ion binding]; other site 281309009682 putative homodimer-homodimer interface [polypeptide binding]; other site 281309009683 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 281309009684 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281309009685 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281309009686 Walker A/P-loop; other site 281309009687 ATP binding site [chemical binding]; other site 281309009688 Q-loop/lid; other site 281309009689 ABC transporter signature motif; other site 281309009690 Walker B; other site 281309009691 D-loop; other site 281309009692 H-loop/switch region; other site 281309009693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309009694 ABC-ATPase subunit interface; other site 281309009695 dimer interface [polypeptide binding]; other site 281309009696 putative PBP binding regions; other site 281309009697 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309009698 ABC-ATPase subunit interface; other site 281309009699 dimer interface [polypeptide binding]; other site 281309009700 putative PBP binding regions; other site 281309009701 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309009702 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 281309009703 putative ligand binding residues [chemical binding]; other site 281309009704 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 281309009705 active site 281309009706 putative catalytic site [active] 281309009707 DNA binding site [nucleotide binding] 281309009708 putative phosphate binding site [ion binding]; other site 281309009709 metal binding site A [ion binding]; metal-binding site 281309009710 AP binding site [nucleotide binding]; other site 281309009711 metal binding site B [ion binding]; metal-binding site 281309009712 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 281309009713 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 281309009714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309009715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309009716 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 281309009717 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 281309009718 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 281309009719 DNA binding site [nucleotide binding] 281309009720 active site 281309009721 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 281309009722 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 281309009723 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 281309009724 minor groove reading motif; other site 281309009725 helix-hairpin-helix signature motif; other site 281309009726 substrate binding pocket [chemical binding]; other site 281309009727 active site 281309009728 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 281309009729 peptidase T-like protein; Region: PepT-like; TIGR01883 281309009730 metal binding site [ion binding]; metal-binding site 281309009731 dimer interface [polypeptide binding]; other site 281309009732 Predicted membrane protein [Function unknown]; Region: COG2364 281309009733 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309009734 hypothetical protein; Provisional; Region: PRK06764 281309009735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309009736 catalytic core [active] 281309009737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309009738 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309009739 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 281309009740 active site 281309009741 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 281309009742 PAS domain S-box; Region: sensory_box; TIGR00229 281309009743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309009744 putative active site [active] 281309009745 heme pocket [chemical binding]; other site 281309009746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309009747 metal binding site [ion binding]; metal-binding site 281309009748 active site 281309009749 I-site; other site 281309009750 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309009751 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 281309009752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 281309009753 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 281309009754 LrgA family; Region: LrgA; cl00608 281309009755 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 281309009756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309009757 DNA-binding site [nucleotide binding]; DNA binding site 281309009758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309009759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309009760 homodimer interface [polypeptide binding]; other site 281309009761 catalytic residue [active] 281309009762 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 281309009763 active site 281309009764 catalytic site [active] 281309009765 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 281309009766 putative active site [active] 281309009767 putative catalytic triad [active] 281309009768 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 281309009769 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309009770 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 281309009771 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309009772 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 281309009773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309009774 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 281309009775 Sulfatase; Region: Sulfatase; pfam00884 281309009776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309009777 binding surface 281309009778 TPR motif; other site 281309009779 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 281309009780 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 281309009781 G1 box; other site 281309009782 GTP/Mg2+ binding site [chemical binding]; other site 281309009783 Switch I region; other site 281309009784 G3 box; other site 281309009785 Switch II region; other site 281309009786 G4 box; other site 281309009787 G5 box; other site 281309009788 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 281309009789 active site 281309009790 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 281309009791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309009792 ATP binding site [chemical binding]; other site 281309009793 Mg2+ binding site [ion binding]; other site 281309009794 G-X-G motif; other site 281309009795 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 281309009796 ATP binding site [chemical binding]; other site 281309009797 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 281309009798 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 281309009799 MutS domain I; Region: MutS_I; pfam01624 281309009800 MutS domain II; Region: MutS_II; pfam05188 281309009801 MutS domain III; Region: MutS_III; pfam05192 281309009802 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 281309009803 Walker A/P-loop; other site 281309009804 ATP binding site [chemical binding]; other site 281309009805 Q-loop/lid; other site 281309009806 ABC transporter signature motif; other site 281309009807 Walker B; other site 281309009808 D-loop; other site 281309009809 H-loop/switch region; other site 281309009810 Outer spore coat protein E (CotE); Region: CotE; pfam10628 281309009811 Predicted membrane protein [Function unknown]; Region: COG4550 281309009812 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 281309009813 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 281309009814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309009815 FeS/SAM binding site; other site 281309009816 TRAM domain; Region: TRAM; pfam01938 281309009817 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 281309009818 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 281309009819 TPP-binding site [chemical binding]; other site 281309009820 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 281309009821 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 281309009822 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 281309009823 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 281309009824 dimer interface [polypeptide binding]; other site 281309009825 PYR/PP interface [polypeptide binding]; other site 281309009826 TPP binding site [chemical binding]; other site 281309009827 substrate binding site [chemical binding]; other site 281309009828 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 281309009829 active site 281309009830 dimer interface [polypeptide binding]; other site 281309009831 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 281309009832 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 281309009833 putative active site [active] 281309009834 metal binding site [ion binding]; metal-binding site 281309009835 homodimer binding site [polypeptide binding]; other site 281309009836 phosphodiesterase; Provisional; Region: PRK12704 281309009837 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 281309009838 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 281309009839 KH domain; Region: KH_1; pfam00013 281309009840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309009841 Zn2+ binding site [ion binding]; other site 281309009842 Mg2+ binding site [ion binding]; other site 281309009843 recA bacterial DNA recombination protein; Region: RecA; cl19152 281309009844 recA bacterial DNA recombination protein; Region: RecA; cl19152 281309009845 competence damage-inducible protein A; Provisional; Region: PRK00549 281309009846 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 281309009847 putative MPT binding site; other site 281309009848 Competence-damaged protein; Region: CinA; pfam02464 281309009849 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 281309009850 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 281309009851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309009852 non-specific DNA binding site [nucleotide binding]; other site 281309009853 salt bridge; other site 281309009854 sequence-specific DNA binding site [nucleotide binding]; other site 281309009855 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 281309009856 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 281309009857 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 281309009858 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 281309009859 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 281309009860 classical (c) SDRs; Region: SDR_c; cd05233 281309009861 NAD(P) binding site [chemical binding]; other site 281309009862 active site 281309009863 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 281309009864 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 281309009865 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 281309009866 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 281309009867 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 281309009868 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 281309009869 TM-ABC transporter signature motif; other site 281309009870 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 281309009871 TM-ABC transporter signature motif; other site 281309009872 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 281309009873 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281309009874 Walker A/P-loop; other site 281309009875 ATP binding site [chemical binding]; other site 281309009876 Q-loop/lid; other site 281309009877 ABC transporter signature motif; other site 281309009878 Walker B; other site 281309009879 D-loop; other site 281309009880 H-loop/switch region; other site 281309009881 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281309009882 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 281309009883 ligand binding site [chemical binding]; other site 281309009884 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 281309009885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309009886 DNA-binding site [nucleotide binding]; DNA binding site 281309009887 UTRA domain; Region: UTRA; pfam07702 281309009888 Tetraspanin family; Region: Tetraspannin; pfam00335 281309009889 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 281309009890 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 281309009891 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 281309009892 YlzJ-like protein; Region: YlzJ; pfam14035 281309009893 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 281309009894 active site 281309009895 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 281309009896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309009897 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 281309009898 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 281309009899 dimer interface [polypeptide binding]; other site 281309009900 active site 281309009901 catalytic residue [active] 281309009902 aspartate kinase I; Reviewed; Region: PRK08210 281309009903 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 281309009904 nucleotide binding site [chemical binding]; other site 281309009905 substrate binding site [chemical binding]; other site 281309009906 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 281309009907 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 281309009908 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 281309009909 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 281309009910 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 281309009911 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 281309009912 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 281309009913 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 281309009914 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 281309009915 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 281309009916 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 281309009917 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 281309009918 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 281309009919 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 281309009920 NodB motif; other site 281309009921 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 281309009922 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 281309009923 RNase E interface [polypeptide binding]; other site 281309009924 trimer interface [polypeptide binding]; other site 281309009925 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 281309009926 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 281309009927 RNase E interface [polypeptide binding]; other site 281309009928 trimer interface [polypeptide binding]; other site 281309009929 active site 281309009930 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 281309009931 putative nucleic acid binding region [nucleotide binding]; other site 281309009932 G-X-X-G motif; other site 281309009933 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 281309009934 RNA binding site [nucleotide binding]; other site 281309009935 domain interface; other site 281309009936 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 281309009937 16S/18S rRNA binding site [nucleotide binding]; other site 281309009938 S13e-L30e interaction site [polypeptide binding]; other site 281309009939 25S rRNA binding site [nucleotide binding]; other site 281309009940 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 281309009941 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 281309009942 active site 281309009943 Riboflavin kinase; Region: Flavokinase; smart00904 281309009944 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 281309009945 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 281309009946 RNA binding site [nucleotide binding]; other site 281309009947 active site 281309009948 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 281309009949 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 281309009950 Protein of unknown function (DUF503); Region: DUF503; pfam04456 281309009951 translation initiation factor IF-2; Validated; Region: infB; PRK05306 281309009952 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 281309009953 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 281309009954 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 281309009955 G1 box; other site 281309009956 putative GEF interaction site [polypeptide binding]; other site 281309009957 GTP/Mg2+ binding site [chemical binding]; other site 281309009958 Switch I region; other site 281309009959 G2 box; other site 281309009960 G3 box; other site 281309009961 Switch II region; other site 281309009962 G4 box; other site 281309009963 G5 box; other site 281309009964 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 281309009965 Translation-initiation factor 2; Region: IF-2; pfam11987 281309009966 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 281309009967 hypothetical protein; Provisional; Region: PRK07714 281309009968 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 281309009969 putative RNA binding cleft [nucleotide binding]; other site 281309009970 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 281309009971 NusA N-terminal domain; Region: NusA_N; pfam08529 281309009972 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 281309009973 RNA binding site [nucleotide binding]; other site 281309009974 homodimer interface [polypeptide binding]; other site 281309009975 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 281309009976 G-X-X-G motif; other site 281309009977 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 281309009978 G-X-X-G motif; other site 281309009979 Sm and related proteins; Region: Sm_like; cl00259 281309009980 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 281309009981 putative oligomer interface [polypeptide binding]; other site 281309009982 putative RNA binding site [nucleotide binding]; other site 281309009983 DNA polymerase III PolC; Validated; Region: polC; PRK00448 281309009984 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 281309009985 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 281309009986 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 281309009987 generic binding surface II; other site 281309009988 generic binding surface I; other site 281309009989 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 281309009990 active site 281309009991 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 281309009992 active site 281309009993 catalytic site [active] 281309009994 substrate binding site [chemical binding]; other site 281309009995 putative PHP Thumb interface [polypeptide binding]; other site 281309009996 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 281309009997 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 281309009998 prolyl-tRNA synthetase; Provisional; Region: PRK09194 281309009999 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 281309010000 dimer interface [polypeptide binding]; other site 281309010001 motif 1; other site 281309010002 active site 281309010003 motif 2; other site 281309010004 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 281309010005 putative deacylase active site [active] 281309010006 motif 3; other site 281309010007 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 281309010008 anticodon binding site; other site 281309010009 RIP metalloprotease RseP; Region: TIGR00054 281309010010 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 281309010011 active site 281309010012 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 281309010013 protein binding site [polypeptide binding]; other site 281309010014 putative substrate binding region [chemical binding]; other site 281309010015 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 281309010016 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 281309010017 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 281309010018 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 281309010019 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 281309010020 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 281309010021 active site 281309010022 dimer interface [polypeptide binding]; other site 281309010023 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 281309010024 hinge region; other site 281309010025 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 281309010026 putative nucleotide binding site [chemical binding]; other site 281309010027 uridine monophosphate binding site [chemical binding]; other site 281309010028 homohexameric interface [polypeptide binding]; other site 281309010029 elongation factor Ts; Provisional; Region: tsf; PRK09377 281309010030 UBA/TS-N domain; Region: UBA; pfam00627 281309010031 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 281309010032 rRNA interaction site [nucleotide binding]; other site 281309010033 S8 interaction site; other site 281309010034 putative laminin-1 binding site; other site 281309010035 transcriptional repressor CodY; Validated; Region: PRK04158 281309010036 CodY GAF-like domain; Region: CodY; pfam06018 281309010037 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 281309010038 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 281309010039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309010040 Walker A motif; other site 281309010041 ATP binding site [chemical binding]; other site 281309010042 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 281309010043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 281309010044 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 281309010045 active site 281309010046 HslU subunit interaction site [polypeptide binding]; other site 281309010047 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 281309010048 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 281309010049 active site 281309010050 Int/Topo IB signature motif; other site 281309010051 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 281309010052 Glucose inhibited division protein A; Region: GIDA; pfam01134 281309010053 DNA topoisomerase I; Validated; Region: PRK05582 281309010054 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 281309010055 active site 281309010056 interdomain interaction site; other site 281309010057 putative metal-binding site [ion binding]; other site 281309010058 nucleotide binding site [chemical binding]; other site 281309010059 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 281309010060 domain I; other site 281309010061 DNA binding groove [nucleotide binding] 281309010062 phosphate binding site [ion binding]; other site 281309010063 domain II; other site 281309010064 domain III; other site 281309010065 nucleotide binding site [chemical binding]; other site 281309010066 catalytic site [active] 281309010067 domain IV; other site 281309010068 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 281309010069 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 281309010070 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 281309010071 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 281309010072 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 281309010073 CoA binding domain; Region: CoA_binding; pfam02629 281309010074 CoA-ligase; Region: Ligase_CoA; pfam00549 281309010075 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 281309010076 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 281309010077 CoA-ligase; Region: Ligase_CoA; pfam00549 281309010078 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 281309010079 RNA/DNA hybrid binding site [nucleotide binding]; other site 281309010080 active site 281309010081 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 281309010082 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 281309010083 GTP/Mg2+ binding site [chemical binding]; other site 281309010084 G4 box; other site 281309010085 G5 box; other site 281309010086 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 281309010087 G1 box; other site 281309010088 G1 box; other site 281309010089 GTP/Mg2+ binding site [chemical binding]; other site 281309010090 Switch I region; other site 281309010091 G2 box; other site 281309010092 G2 box; other site 281309010093 G3 box; other site 281309010094 G3 box; other site 281309010095 Switch II region; other site 281309010096 Switch II region; other site 281309010097 G4 box; other site 281309010098 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 281309010099 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281309010100 Catalytic site [active] 281309010101 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 281309010102 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 281309010103 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 281309010104 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 281309010105 RimM N-terminal domain; Region: RimM; pfam01782 281309010106 PRC-barrel domain; Region: PRC; pfam05239 281309010107 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 281309010108 G-X-X-G motif; other site 281309010109 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 281309010110 signal recognition particle protein; Provisional; Region: PRK10867 281309010111 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 281309010112 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 281309010113 P loop; other site 281309010114 GTP binding site [chemical binding]; other site 281309010115 Signal peptide binding domain; Region: SRP_SPB; pfam02978 281309010116 putative DNA-binding protein; Validated; Region: PRK00118 281309010117 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 281309010118 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 281309010119 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 281309010120 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 281309010121 P loop; other site 281309010122 GTP binding site [chemical binding]; other site 281309010123 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 281309010124 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 281309010125 Walker A/P-loop; other site 281309010126 ATP binding site [chemical binding]; other site 281309010127 Q-loop/lid; other site 281309010128 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 281309010129 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 281309010130 ABC transporter signature motif; other site 281309010131 Walker B; other site 281309010132 D-loop; other site 281309010133 H-loop/switch region; other site 281309010134 ribonuclease III; Reviewed; Region: rnc; PRK00102 281309010135 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 281309010136 dimerization interface [polypeptide binding]; other site 281309010137 active site 281309010138 metal binding site [ion binding]; metal-binding site 281309010139 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 281309010140 dsRNA binding site [nucleotide binding]; other site 281309010141 acyl carrier protein; Provisional; Region: acpP; PRK00982 281309010142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 281309010143 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 281309010144 NAD(P) binding site [chemical binding]; other site 281309010145 homotetramer interface [polypeptide binding]; other site 281309010146 homodimer interface [polypeptide binding]; other site 281309010147 active site 281309010148 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 281309010149 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 281309010150 putative phosphate acyltransferase; Provisional; Region: PRK05331 281309010151 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 281309010152 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 281309010153 active site 2 [active] 281309010154 active site 1 [active] 281309010155 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 281309010156 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 281309010157 generic binding surface II; other site 281309010158 ssDNA binding site; other site 281309010159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309010160 ATP binding site [chemical binding]; other site 281309010161 putative Mg++ binding site [ion binding]; other site 281309010162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309010163 nucleotide binding region [chemical binding]; other site 281309010164 ATP-binding site [chemical binding]; other site 281309010165 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 281309010166 DAK2 domain; Region: Dak2; pfam02734 281309010167 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 281309010168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 281309010169 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 281309010170 Thiamine pyrophosphokinase; Region: TPK; cd07995 281309010171 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 281309010172 active site 281309010173 dimerization interface [polypeptide binding]; other site 281309010174 thiamine binding site [chemical binding]; other site 281309010175 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 281309010176 substrate binding site [chemical binding]; other site 281309010177 hexamer interface [polypeptide binding]; other site 281309010178 metal binding site [ion binding]; metal-binding site 281309010179 GTPase RsgA; Reviewed; Region: PRK00098 281309010180 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 281309010181 RNA binding site [nucleotide binding]; other site 281309010182 homodimer interface [polypeptide binding]; other site 281309010183 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 281309010184 GTPase/Zn-binding domain interface [polypeptide binding]; other site 281309010185 GTP/Mg2+ binding site [chemical binding]; other site 281309010186 G4 box; other site 281309010187 G5 box; other site 281309010188 G1 box; other site 281309010189 Switch I region; other site 281309010190 G2 box; other site 281309010191 G3 box; other site 281309010192 Switch II region; other site 281309010193 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281309010194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 281309010195 active site 281309010196 ATP binding site [chemical binding]; other site 281309010197 substrate binding site [chemical binding]; other site 281309010198 activation loop (A-loop); other site 281309010199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 281309010200 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281309010201 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281309010202 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281309010203 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 281309010204 active site 281309010205 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 281309010206 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 281309010207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309010208 FeS/SAM binding site; other site 281309010209 16S rRNA methyltransferase B; Provisional; Region: PRK14902 281309010210 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 281309010211 putative RNA binding site [nucleotide binding]; other site 281309010212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309010213 S-adenosylmethionine binding site [chemical binding]; other site 281309010214 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 281309010215 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 281309010216 putative active site [active] 281309010217 substrate binding site [chemical binding]; other site 281309010218 putative cosubstrate binding site; other site 281309010219 catalytic site [active] 281309010220 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 281309010221 substrate binding site [chemical binding]; other site 281309010222 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 281309010223 active site 281309010224 catalytic residues [active] 281309010225 metal binding site [ion binding]; metal-binding site 281309010226 primosome assembly protein PriA; Validated; Region: PRK05580 281309010227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309010228 ATP binding site [chemical binding]; other site 281309010229 putative Mg++ binding site [ion binding]; other site 281309010230 helicase superfamily c-terminal domain; Region: HELICc; smart00490 281309010231 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 281309010232 Flavoprotein; Region: Flavoprotein; cl19190 281309010233 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 281309010234 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 281309010235 Guanylate kinase; Region: Guanylate_kin; pfam00625 281309010236 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 281309010237 catalytic site [active] 281309010238 G-X2-G-X-G-K; other site 281309010239 hypothetical protein; Provisional; Region: PRK04323 281309010240 hypothetical protein; Provisional; Region: PRK11820 281309010241 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 281309010242 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 281309010243 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 281309010244 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 281309010245 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281309010246 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 281309010247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309010248 motif II; other site 281309010249 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 281309010250 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 281309010251 Domain of unknown function (DUF814); Region: DUF814; pfam05670 281309010252 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 281309010253 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 281309010254 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 281309010255 active site 281309010256 DinB superfamily; Region: DinB_2; pfam12867 281309010257 YoqO-like protein; Region: YoqO; pfam14037 281309010258 YoqO-like protein; Region: YoqO; pfam14037 281309010259 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 281309010260 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 281309010261 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 281309010262 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 281309010263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309010264 motif II; other site 281309010265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309010266 active site 281309010267 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 281309010268 active site 281309010269 dimer interface [polypeptide binding]; other site 281309010270 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 281309010271 heterodimer interface [polypeptide binding]; other site 281309010272 active site 281309010273 FMN binding site [chemical binding]; other site 281309010274 homodimer interface [polypeptide binding]; other site 281309010275 substrate binding site [chemical binding]; other site 281309010276 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 281309010277 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 281309010278 FAD binding pocket [chemical binding]; other site 281309010279 FAD binding motif [chemical binding]; other site 281309010280 phosphate binding motif [ion binding]; other site 281309010281 beta-alpha-beta structure motif; other site 281309010282 NAD binding pocket [chemical binding]; other site 281309010283 Iron coordination center [ion binding]; other site 281309010284 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 281309010285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281309010286 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 281309010287 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 281309010288 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281309010289 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281309010290 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 281309010291 IMP binding site; other site 281309010292 dimer interface [polypeptide binding]; other site 281309010293 interdomain contacts; other site 281309010294 partial ornithine binding site; other site 281309010295 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 281309010296 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 281309010297 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 281309010298 catalytic site [active] 281309010299 subunit interface [polypeptide binding]; other site 281309010300 dihydroorotase; Validated; Region: pyrC; PRK09357 281309010301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 281309010302 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 281309010303 active site 281309010304 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 281309010305 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 281309010306 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 281309010307 Sulfate transporter family; Region: Sulfate_transp; cl19250 281309010308 uracil-xanthine permease; Region: ncs2; TIGR00801 281309010309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309010310 active site 281309010311 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 281309010312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309010313 RNA binding surface [nucleotide binding]; other site 281309010314 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 281309010315 active site 281309010316 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 281309010317 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 281309010318 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 281309010319 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 281309010320 active site 281309010321 HIGH motif; other site 281309010322 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 281309010323 KMSKS motif; other site 281309010324 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 281309010325 tRNA binding surface [nucleotide binding]; other site 281309010326 anticodon binding site; other site 281309010327 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 281309010328 DivIVA protein; Region: DivIVA; pfam05103 281309010329 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 281309010330 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 281309010331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309010332 RNA binding surface [nucleotide binding]; other site 281309010333 YGGT family; Region: YGGT; pfam02325 281309010334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 281309010335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 281309010336 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281309010337 catalytic residue [active] 281309010338 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 281309010339 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 281309010340 sporulation sigma factor SigG; Reviewed; Region: PRK08215 281309010341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309010342 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281309010343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309010344 DNA binding residues [nucleotide binding] 281309010345 sporulation sigma factor SigE; Reviewed; Region: PRK08301 281309010346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309010347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309010348 DNA binding residues [nucleotide binding] 281309010349 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 281309010350 cell division protein FtsZ; Validated; Region: PRK09330 281309010351 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 281309010352 nucleotide binding site [chemical binding]; other site 281309010353 SulA interaction site; other site 281309010354 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 281309010355 Cell division protein FtsA; Region: FtsA; smart00842 281309010356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309010357 nucleotide binding site [chemical binding]; other site 281309010358 Cell division protein FtsA; Region: FtsA; pfam14450 281309010359 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 281309010360 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 281309010361 Cell division protein FtsQ; Region: FtsQ; pfam03799 281309010362 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 281309010363 FAD binding domain; Region: FAD_binding_4; pfam01565 281309010364 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 281309010365 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 281309010366 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 281309010367 active site 281309010368 homodimer interface [polypeptide binding]; other site 281309010369 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 281309010370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309010371 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 281309010372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309010373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309010374 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 281309010375 Mg++ binding site [ion binding]; other site 281309010376 putative catalytic motif [active] 281309010377 putative substrate binding site [chemical binding]; other site 281309010378 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 281309010379 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281309010380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309010381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309010382 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 281309010383 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309010384 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309010385 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 281309010386 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309010387 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309010388 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309010389 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 281309010390 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 281309010391 Cell division protein FtsL; Region: FtsL; cl11433 281309010392 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 281309010393 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 281309010394 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 281309010395 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 281309010396 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 281309010397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309010398 Coenzyme A binding pocket [chemical binding]; other site 281309010399 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 281309010400 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 281309010401 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 281309010402 hypothetical protein; Provisional; Region: PRK13670 281309010403 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 281309010404 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 281309010405 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 281309010406 protein binding site [polypeptide binding]; other site 281309010407 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 281309010408 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 281309010409 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 281309010410 active site 281309010411 nucleophile elbow; other site 281309010412 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 281309010413 Nucleoside recognition; Region: Gate; pfam07670 281309010414 Nucleoside recognition; Region: Gate; pfam07670 281309010415 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 281309010416 active site 281309010417 (T/H)XGH motif; other site 281309010418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309010419 S-adenosylmethionine binding site [chemical binding]; other site 281309010420 hypothetical protein; Provisional; Region: PRK02886 281309010421 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 281309010422 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309010423 catalytic core [active] 281309010424 YlbE-like protein; Region: YlbE; pfam14003 281309010425 Putative coat protein; Region: YlbD_coat; pfam14071 281309010426 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 281309010427 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 281309010428 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 281309010429 YugN-like family; Region: YugN; pfam08868 281309010430 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 281309010431 multimer interface [polypeptide binding]; other site 281309010432 active site 281309010433 catalytic triad [active] 281309010434 dimer interface [polypeptide binding]; other site 281309010435 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 281309010436 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 281309010437 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 281309010438 Subunit I/III interface [polypeptide binding]; other site 281309010439 Subunit III/IV interface [polypeptide binding]; other site 281309010440 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 281309010441 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 281309010442 D-pathway; other site 281309010443 Putative ubiquinol binding site [chemical binding]; other site 281309010444 Low-spin heme (heme b) binding site [chemical binding]; other site 281309010445 Putative water exit pathway; other site 281309010446 Binuclear center (heme o3/CuB) [ion binding]; other site 281309010447 K-pathway; other site 281309010448 Putative proton exit pathway; other site 281309010449 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 281309010450 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 281309010451 oligomer interface [polypeptide binding]; other site 281309010452 CuA binuclear center [ion binding]; other site 281309010453 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 281309010454 Cytochrome c; Region: Cytochrom_C; pfam00034 281309010455 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 281309010456 putative active site [active] 281309010457 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 281309010458 pyruvate carboxylase; Reviewed; Region: PRK12999 281309010459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281309010460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 281309010461 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 281309010462 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 281309010463 active site 281309010464 catalytic residues [active] 281309010465 metal binding site [ion binding]; metal-binding site 281309010466 homodimer binding site [polypeptide binding]; other site 281309010467 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 281309010468 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 281309010469 carboxyltransferase (CT) interaction site; other site 281309010470 biotinylation site [posttranslational modification]; other site 281309010471 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 281309010472 hypothetical protein; Provisional; Region: PRK13666 281309010473 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 281309010474 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309010475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309010476 Transposase domain (DUF772); Region: DUF772; pfam05598 281309010477 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309010478 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 281309010479 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 281309010480 putative active site [active] 281309010481 PhoH-like protein; Region: PhoH; pfam02562 281309010482 hypothetical protein; Provisional; Region: PRK06733 281309010483 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 281309010484 YlaH-like protein; Region: YlaH; pfam14036 281309010485 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 281309010486 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 281309010487 G1 box; other site 281309010488 putative GEF interaction site [polypeptide binding]; other site 281309010489 GTP/Mg2+ binding site [chemical binding]; other site 281309010490 Switch I region; other site 281309010491 G2 box; other site 281309010492 G3 box; other site 281309010493 Switch II region; other site 281309010494 G4 box; other site 281309010495 G5 box; other site 281309010496 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 281309010497 Elongation Factor G, domain II; Region: EFG_II; pfam14492 281309010498 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 281309010499 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 281309010500 active site 281309010501 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 281309010502 hypothetical protein; Provisional; Region: PRK04387 281309010503 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 281309010504 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 281309010505 homodimer interface [polypeptide binding]; other site 281309010506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309010507 catalytic residue [active] 281309010508 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 281309010509 transglutaminase; Provisional; Region: tgl; PRK03187 281309010510 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 281309010511 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 281309010512 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 281309010513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309010514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309010515 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 281309010516 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 281309010517 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 281309010518 E3 interaction surface; other site 281309010519 lipoyl attachment site [posttranslational modification]; other site 281309010520 e3 binding domain; Region: E3_binding; pfam02817 281309010521 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281309010522 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 281309010523 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 281309010524 alpha subunit interface [polypeptide binding]; other site 281309010525 TPP binding site [chemical binding]; other site 281309010526 heterodimer interface [polypeptide binding]; other site 281309010527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281309010528 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 281309010529 TPP-binding site [chemical binding]; other site 281309010530 heterodimer interface [polypeptide binding]; other site 281309010531 tetramer interface [polypeptide binding]; other site 281309010532 phosphorylation loop region [posttranslational modification] 281309010533 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 281309010534 active site 281309010535 catalytic residues [active] 281309010536 metal binding site [ion binding]; metal-binding site 281309010537 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 281309010538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309010539 active site 281309010540 motif I; other site 281309010541 motif II; other site 281309010542 hypothetical protein; Provisional; Region: PRK13667 281309010543 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 281309010544 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309010545 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 281309010546 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 281309010547 TrkA-N domain; Region: TrkA_N; pfam02254 281309010548 TrkA-C domain; Region: TrkA_C; pfam02080 281309010549 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 281309010550 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 281309010551 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 281309010552 metal binding site [ion binding]; metal-binding site 281309010553 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 281309010554 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 281309010555 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 281309010556 trimer interface [polypeptide binding]; other site 281309010557 active site 281309010558 substrate binding site [chemical binding]; other site 281309010559 CoA binding site [chemical binding]; other site 281309010560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309010561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309010562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309010563 dimerization interface [polypeptide binding]; other site 281309010564 FOG: CBS domain [General function prediction only]; Region: COG0517 281309010565 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 281309010566 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 281309010567 Protein of unknown function (DUF458); Region: DUF458; pfam04308 281309010568 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 281309010569 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 281309010570 catalytic residues [active] 281309010571 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 281309010572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309010573 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 281309010574 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 281309010575 short chain dehydrogenase; Provisional; Region: PRK07677 281309010576 NAD(P) binding site [chemical binding]; other site 281309010577 substrate binding site [chemical binding]; other site 281309010578 homotetramer interface [polypeptide binding]; other site 281309010579 active site 281309010580 homodimer interface [polypeptide binding]; other site 281309010581 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 281309010582 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 281309010583 putative active site [active] 281309010584 putative metal binding site [ion binding]; other site 281309010585 polyphosphate kinase; Provisional; Region: PRK05443 281309010586 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 281309010587 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 281309010588 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 281309010589 putative domain interface [polypeptide binding]; other site 281309010590 putative active site [active] 281309010591 catalytic site [active] 281309010592 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 281309010593 putative domain interface [polypeptide binding]; other site 281309010594 putative active site [active] 281309010595 catalytic site [active] 281309010596 exopolyphosphatase; Region: exo_poly_only; TIGR03706 281309010597 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 281309010598 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309010599 nucleotide binding site [chemical binding]; other site 281309010600 YkyB-like protein; Region: YkyB; pfam14177 281309010601 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 281309010602 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 281309010603 metal binding site [ion binding]; metal-binding site 281309010604 Phage lysis protein, holin; Region: Phage_holin; cl04675 281309010605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309010606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309010607 putative substrate translocation pore; other site 281309010608 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309010609 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 281309010610 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 281309010611 THF binding site; other site 281309010612 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 281309010613 substrate binding site [chemical binding]; other site 281309010614 THF binding site; other site 281309010615 zinc-binding site [ion binding]; other site 281309010616 Competence protein J (ComJ); Region: ComJ; pfam11033 281309010617 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 281309010618 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 281309010619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309010620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309010621 dimer interface [polypeptide binding]; other site 281309010622 phosphorylation site [posttranslational modification] 281309010623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309010624 ATP binding site [chemical binding]; other site 281309010625 Mg2+ binding site [ion binding]; other site 281309010626 G-X-G motif; other site 281309010627 aminotransferase A; Validated; Region: PRK07683 281309010628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309010629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309010630 homodimer interface [polypeptide binding]; other site 281309010631 catalytic residue [active] 281309010632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309010633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309010634 DNA binding site [nucleotide binding] 281309010635 domain linker motif; other site 281309010636 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 281309010637 putative dimerization interface [polypeptide binding]; other site 281309010638 putative ligand binding site [chemical binding]; other site 281309010639 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281309010640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309010641 dimer interface [polypeptide binding]; other site 281309010642 conserved gate region; other site 281309010643 putative PBP binding loops; other site 281309010644 ABC-ATPase subunit interface; other site 281309010645 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 281309010646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309010647 dimer interface [polypeptide binding]; other site 281309010648 conserved gate region; other site 281309010649 putative PBP binding loops; other site 281309010650 ABC-ATPase subunit interface; other site 281309010651 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 281309010652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 281309010653 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 281309010654 homodimer interface [polypeptide binding]; other site 281309010655 maltodextrin glucosidase; Provisional; Region: PRK10785 281309010656 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 281309010657 active site 281309010658 homodimer interface [polypeptide binding]; other site 281309010659 catalytic site [active] 281309010660 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 281309010661 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 281309010662 Ca binding site [ion binding]; other site 281309010663 active site 281309010664 catalytic site [active] 281309010665 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 281309010666 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 281309010667 Walker A/P-loop; other site 281309010668 ATP binding site [chemical binding]; other site 281309010669 Q-loop/lid; other site 281309010670 ABC transporter signature motif; other site 281309010671 Walker B; other site 281309010672 D-loop; other site 281309010673 H-loop/switch region; other site 281309010674 TOBE domain; Region: TOBE_2; pfam08402 281309010675 hypothetical protein; Provisional; Region: PRK06720 281309010676 NAD(P) binding site [chemical binding]; other site 281309010677 RDD family; Region: RDD; pfam06271 281309010678 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 281309010679 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 281309010680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309010681 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 281309010682 Walker A/P-loop; other site 281309010683 ATP binding site [chemical binding]; other site 281309010684 Q-loop/lid; other site 281309010685 ABC transporter signature motif; other site 281309010686 Walker B; other site 281309010687 D-loop; other site 281309010688 H-loop/switch region; other site 281309010689 putative acyltransferase; Provisional; Region: PRK05790 281309010690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 281309010691 dimer interface [polypeptide binding]; other site 281309010692 active site 281309010693 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 281309010694 nudix motif; other site 281309010695 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 281309010696 hypothetical protein; Validated; Region: PRK07668 281309010697 hypothetical protein; Validated; Region: PRK07668 281309010698 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309010699 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 281309010700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309010701 NAD(P) binding site [chemical binding]; other site 281309010702 active site 281309010703 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 281309010704 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 281309010705 Phosphotransferase enzyme family; Region: APH; pfam01636 281309010706 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 281309010707 putative active site [active] 281309010708 catalytic triad [active] 281309010709 putative dimer interface [polypeptide binding]; other site 281309010710 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 281309010711 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309010712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309010713 homodimer interface [polypeptide binding]; other site 281309010714 catalytic residue [active] 281309010715 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 281309010716 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 281309010717 dimer interface [polypeptide binding]; other site 281309010718 active site 281309010719 catalytic residue [active] 281309010720 metal binding site [ion binding]; metal-binding site 281309010721 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 281309010722 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 281309010723 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 281309010724 intersubunit interface [polypeptide binding]; other site 281309010725 active site 281309010726 Zn2+ binding site [ion binding]; other site 281309010727 Cupin domain; Region: Cupin_2; cl17218 281309010728 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 281309010729 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 281309010730 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 281309010731 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 281309010732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309010733 metal binding site [ion binding]; metal-binding site 281309010734 active site 281309010735 I-site; other site 281309010736 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 281309010737 dimer interface [polypeptide binding]; other site 281309010738 FMN binding site [chemical binding]; other site 281309010739 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 281309010740 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 281309010741 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 281309010742 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 281309010743 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 281309010744 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 281309010745 dimerization domain swap beta strand [polypeptide binding]; other site 281309010746 regulatory protein interface [polypeptide binding]; other site 281309010747 active site 281309010748 regulatory phosphorylation site [posttranslational modification]; other site 281309010749 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 281309010750 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 281309010751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 281309010752 active site turn [active] 281309010753 phosphorylation site [posttranslational modification] 281309010754 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 281309010755 HPr interaction site; other site 281309010756 glycerol kinase (GK) interaction site [polypeptide binding]; other site 281309010757 active site 281309010758 phosphorylation site [posttranslational modification] 281309010759 transcriptional antiterminator BglG; Provisional; Region: PRK09772 281309010760 CAT RNA binding domain; Region: CAT_RBD; smart01061 281309010761 PRD domain; Region: PRD; pfam00874 281309010762 PRD domain; Region: PRD; pfam00874 281309010763 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 281309010764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309010765 active site 281309010766 motif I; other site 281309010767 motif II; other site 281309010768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309010769 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309010770 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 281309010771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309010772 DNA-binding site [nucleotide binding]; DNA binding site 281309010773 UTRA domain; Region: UTRA; pfam07702 281309010774 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 281309010775 active site 281309010776 trimer interface [polypeptide binding]; other site 281309010777 allosteric site; other site 281309010778 active site lid [active] 281309010779 hexamer (dimer of trimers) interface [polypeptide binding]; other site 281309010780 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 281309010781 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 281309010782 active site 281309010783 dimer interface [polypeptide binding]; other site 281309010784 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 281309010785 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309010786 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 281309010787 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 281309010788 Domain of unknown function (DUF309); Region: DUF309; pfam03745 281309010789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309010790 Coenzyme A binding pocket [chemical binding]; other site 281309010791 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 281309010792 active site 281309010793 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 281309010794 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 281309010795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309010796 active site 281309010797 motif I; other site 281309010798 motif II; other site 281309010799 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 281309010800 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309010801 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309010802 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 281309010803 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 281309010804 stage V sporulation protein AD; Validated; Region: PRK08304 281309010805 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 281309010806 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 281309010807 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 281309010808 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 281309010809 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 281309010810 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 281309010811 Na2 binding site [ion binding]; other site 281309010812 putative substrate binding site 1 [chemical binding]; other site 281309010813 Na binding site 1 [ion binding]; other site 281309010814 putative substrate binding site 2 [chemical binding]; other site 281309010815 sporulation sigma factor SigF; Validated; Region: PRK05572 281309010816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309010817 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281309010818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309010819 DNA binding residues [nucleotide binding] 281309010820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309010821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309010822 ATP binding site [chemical binding]; other site 281309010823 Mg2+ binding site [ion binding]; other site 281309010824 G-X-G motif; other site 281309010825 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 281309010826 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309010827 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 281309010828 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 281309010829 Predicted transcriptional regulators [Transcription]; Region: COG1725 281309010830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309010831 DNA-binding site [nucleotide binding]; DNA binding site 281309010832 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309010833 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309010834 Walker A/P-loop; other site 281309010835 ATP binding site [chemical binding]; other site 281309010836 Q-loop/lid; other site 281309010837 ABC transporter signature motif; other site 281309010838 Walker B; other site 281309010839 D-loop; other site 281309010840 H-loop/switch region; other site 281309010841 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281309010842 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281309010843 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309010844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309010845 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 281309010846 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 281309010847 Sulfate transporter family; Region: Sulfate_transp; cl19250 281309010848 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 281309010849 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 281309010850 oligomer interface [polypeptide binding]; other site 281309010851 metal binding site [ion binding]; metal-binding site 281309010852 metal binding site [ion binding]; metal-binding site 281309010853 putative Cl binding site [ion binding]; other site 281309010854 aspartate ring; other site 281309010855 basic sphincter; other site 281309010856 hydrophobic gate; other site 281309010857 periplasmic entrance; other site 281309010858 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 281309010859 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 281309010860 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 281309010861 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 281309010862 purine nucleoside phosphorylase; Provisional; Region: PRK08202 281309010863 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 281309010864 phosphopentomutase; Provisional; Region: PRK05362 281309010865 YtkA-like; Region: YtkA; pfam13115 281309010866 YtkA-like; Region: YtkA; pfam13115 281309010867 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 281309010868 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 281309010869 active site 281309010870 Int/Topo IB signature motif; other site 281309010871 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 281309010872 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 281309010873 metal binding site 2 [ion binding]; metal-binding site 281309010874 putative DNA binding helix; other site 281309010875 metal binding site 1 [ion binding]; metal-binding site 281309010876 dimer interface [polypeptide binding]; other site 281309010877 structural Zn2+ binding site [ion binding]; other site 281309010878 stage II sporulation protein M; Region: spo_II_M; TIGR02831 281309010879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309010880 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309010881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309010882 Transposase domain (DUF772); Region: DUF772; pfam05598 281309010883 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309010884 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309010885 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 281309010886 dimer interface [polypeptide binding]; other site 281309010887 ADP-ribose binding site [chemical binding]; other site 281309010888 active site 281309010889 nudix motif; other site 281309010890 metal binding site [ion binding]; metal-binding site 281309010891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309010892 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 281309010893 active site 281309010894 catalytic tetrad [active] 281309010895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309010896 active site 281309010897 catalytic tetrad [active] 281309010898 GrpB protein; Region: GrpB; pfam04229 281309010899 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 281309010900 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 281309010901 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 281309010902 putative active site [active] 281309010903 putative metal binding site [ion binding]; other site 281309010904 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 281309010905 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 281309010906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309010907 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309010908 Predicted permease [General function prediction only]; Region: COG2056 281309010909 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 281309010910 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 281309010911 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309010912 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309010913 DNA binding site [nucleotide binding] 281309010914 domain linker motif; other site 281309010915 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 281309010916 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309010917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309010918 Coenzyme A binding pocket [chemical binding]; other site 281309010919 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 281309010920 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309010921 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 281309010922 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 281309010923 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 281309010924 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 281309010925 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 281309010926 catalytic motif [active] 281309010927 Zn binding site [ion binding]; other site 281309010928 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 281309010929 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 281309010930 Lumazine binding domain; Region: Lum_binding; pfam00677 281309010931 Lumazine binding domain; Region: Lum_binding; pfam00677 281309010932 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 281309010933 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 281309010934 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 281309010935 dimerization interface [polypeptide binding]; other site 281309010936 active site 281309010937 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 281309010938 homopentamer interface [polypeptide binding]; other site 281309010939 active site 281309010940 biotin synthase; Validated; Region: PRK06256 281309010941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309010942 FeS/SAM binding site; other site 281309010943 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 281309010944 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 281309010945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309010946 S-adenosylmethionine binding site [chemical binding]; other site 281309010947 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309010948 Protein of unknown function (DUF452); Region: DUF452; cl01062 281309010949 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309010950 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 281309010951 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 281309010952 substrate-cofactor binding pocket; other site 281309010953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309010954 catalytic residue [active] 281309010955 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 281309010956 AAA domain; Region: AAA_26; pfam13500 281309010957 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309010958 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309010959 inhibitor-cofactor binding pocket; inhibition site 281309010960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309010961 catalytic residue [active] 281309010962 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 281309010963 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 281309010964 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281309010965 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 281309010966 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 281309010967 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 281309010968 active site 281309010969 metal binding site [ion binding]; metal-binding site 281309010970 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 281309010971 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 281309010972 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 281309010973 active site 281309010974 catalytic triad [active] 281309010975 oxyanion hole [active] 281309010976 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309010977 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309010978 dimerization interface [polypeptide binding]; other site 281309010979 putative DNA binding site [nucleotide binding]; other site 281309010980 putative Zn2+ binding site [ion binding]; other site 281309010981 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 281309010982 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281309010983 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309010984 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281309010985 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309010986 Immunity protein 16; Region: Imm16; pfam15565 281309010987 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 281309010988 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 281309010989 ornithine carbamoyltransferase; Provisional; Region: PRK00779 281309010990 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 281309010991 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 281309010992 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 281309010993 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309010994 inhibitor-cofactor binding pocket; inhibition site 281309010995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309010996 catalytic residue [active] 281309010997 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 281309010998 nucleotide binding site [chemical binding]; other site 281309010999 N-acetyl-L-glutamate binding site [chemical binding]; other site 281309011000 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 281309011001 heterotetramer interface [polypeptide binding]; other site 281309011002 active site pocket [active] 281309011003 cleavage site 281309011004 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 281309011005 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 281309011006 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 281309011007 YqzH-like protein; Region: YqzH; pfam14164 281309011008 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 281309011009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309011010 NAD(P) binding site [chemical binding]; other site 281309011011 active site 281309011012 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 281309011013 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 281309011014 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 281309011015 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 281309011016 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 281309011017 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 281309011018 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 281309011019 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 281309011020 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 281309011021 putative L-serine binding site [chemical binding]; other site 281309011022 ribonuclease Z; Region: RNase_Z; TIGR02651 281309011023 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 281309011024 DNA polymerase IV; Validated; Region: PRK01810 281309011025 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 281309011026 active site 281309011027 DNA binding site [nucleotide binding] 281309011028 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 281309011029 peptidase T-like protein; Region: PepT-like; TIGR01883 281309011030 metal binding site [ion binding]; metal-binding site 281309011031 putative dimer interface [polypeptide binding]; other site 281309011032 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309011033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309011034 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 281309011035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 281309011036 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 281309011037 Predicted membrane protein [Function unknown]; Region: COG4129 281309011038 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 281309011039 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 281309011040 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 281309011041 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 281309011042 Walker A/P-loop; other site 281309011043 ATP binding site [chemical binding]; other site 281309011044 Q-loop/lid; other site 281309011045 ABC transporter signature motif; other site 281309011046 Walker B; other site 281309011047 D-loop; other site 281309011048 H-loop/switch region; other site 281309011049 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 281309011050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309011051 dimer interface [polypeptide binding]; other site 281309011052 conserved gate region; other site 281309011053 putative PBP binding loops; other site 281309011054 ABC-ATPase subunit interface; other site 281309011055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 281309011056 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 281309011057 substrate binding pocket [chemical binding]; other site 281309011058 membrane-bound complex binding site; other site 281309011059 hinge residues; other site 281309011060 Disulphide isomerase; Region: Disulph_isomer; pfam06491 281309011061 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 281309011062 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 281309011063 nudix motif; other site 281309011064 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 281309011065 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 281309011066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 281309011067 E3 interaction surface; other site 281309011068 lipoyl attachment site [posttranslational modification]; other site 281309011069 e3 binding domain; Region: E3_binding; pfam02817 281309011070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281309011071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 281309011072 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 281309011073 alpha subunit interface [polypeptide binding]; other site 281309011074 TPP binding site [chemical binding]; other site 281309011075 heterodimer interface [polypeptide binding]; other site 281309011076 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281309011077 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 281309011078 tetramer interface [polypeptide binding]; other site 281309011079 TPP-binding site [chemical binding]; other site 281309011080 heterodimer interface [polypeptide binding]; other site 281309011081 phosphorylation loop region [posttranslational modification] 281309011082 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 281309011083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309011084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309011085 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 281309011086 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309011087 nucleotide binding site [chemical binding]; other site 281309011088 Acetokinase family; Region: Acetate_kinase; cl17229 281309011089 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 281309011090 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 281309011091 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 281309011092 NAD binding site [chemical binding]; other site 281309011093 Phe binding site; other site 281309011094 phosphate butyryltransferase; Validated; Region: PRK07742 281309011095 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 281309011096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309011097 putative active site [active] 281309011098 heme pocket [chemical binding]; other site 281309011099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309011100 putative active site [active] 281309011101 heme pocket [chemical binding]; other site 281309011102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309011103 Walker A motif; other site 281309011104 ATP binding site [chemical binding]; other site 281309011105 Walker B motif; other site 281309011106 arginine finger; other site 281309011107 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 281309011108 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 281309011109 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 281309011110 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 281309011111 active site 281309011112 catalytic site [active] 281309011113 metal binding site [ion binding]; metal-binding site 281309011114 dimer interface [polypeptide binding]; other site 281309011115 conserved hypothetical integral membrane protein; Region: TIGR03766 281309011116 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 281309011117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309011118 active site 281309011119 phosphorylation site [posttranslational modification] 281309011120 intermolecular recognition site; other site 281309011121 dimerization interface [polypeptide binding]; other site 281309011122 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 281309011123 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 281309011124 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 281309011125 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 281309011126 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 281309011127 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 281309011128 Walker A/P-loop; other site 281309011129 ATP binding site [chemical binding]; other site 281309011130 Q-loop/lid; other site 281309011131 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 281309011132 ABC transporter signature motif; other site 281309011133 Walker B; other site 281309011134 D-loop; other site 281309011135 H-loop/switch region; other site 281309011136 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 281309011137 arginine repressor; Provisional; Region: PRK04280 281309011138 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 281309011139 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 281309011140 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309011141 RNA binding surface [nucleotide binding]; other site 281309011142 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 281309011143 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 281309011144 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 281309011145 TPP-binding site; other site 281309011146 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 281309011147 PYR/PP interface [polypeptide binding]; other site 281309011148 dimer interface [polypeptide binding]; other site 281309011149 TPP binding site [chemical binding]; other site 281309011150 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281309011151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 281309011152 substrate binding pocket [chemical binding]; other site 281309011153 chain length determination region; other site 281309011154 active site lid residues [active] 281309011155 substrate-Mg2+ binding site; other site 281309011156 catalytic residues [active] 281309011157 aspartate-rich region 1; other site 281309011158 aspartate-rich region 2; other site 281309011159 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 281309011160 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 281309011161 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 281309011162 generic binding surface II; other site 281309011163 generic binding surface I; other site 281309011164 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 281309011165 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 281309011166 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 281309011167 homodimer interface [polypeptide binding]; other site 281309011168 NADP binding site [chemical binding]; other site 281309011169 substrate binding site [chemical binding]; other site 281309011170 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 281309011171 putative RNA binding site [nucleotide binding]; other site 281309011172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 281309011173 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 281309011174 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281309011175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281309011176 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 281309011177 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 281309011178 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 281309011179 carboxyltransferase (CT) interaction site; other site 281309011180 biotinylation site [posttranslational modification]; other site 281309011181 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 281309011182 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 281309011183 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 281309011184 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 281309011185 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 281309011186 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 281309011187 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 281309011188 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 281309011189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309011190 Walker A motif; other site 281309011191 ATP binding site [chemical binding]; other site 281309011192 Walker B motif; other site 281309011193 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 281309011194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309011195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309011196 elongation factor P; Validated; Region: PRK00529 281309011197 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 281309011198 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 281309011199 RNA binding site [nucleotide binding]; other site 281309011200 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 281309011201 RNA binding site [nucleotide binding]; other site 281309011202 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 281309011203 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 281309011204 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 281309011205 active site 281309011206 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 281309011207 trimer interface [polypeptide binding]; other site 281309011208 active site 281309011209 dimer interface [polypeptide binding]; other site 281309011210 Conserved membrane protein YqhR; Region: YqhR; pfam11085 281309011211 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 281309011212 CCC1-related family of proteins; Region: CCC1_like; cl00278 281309011213 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 281309011214 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 281309011215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309011216 motif II; other site 281309011217 manganese transport transcriptional regulator; Provisional; Region: PRK03902 281309011218 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 281309011219 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 281309011220 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 281309011221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309011222 FeS/SAM binding site; other site 281309011223 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309011224 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 281309011225 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 281309011226 hypothetical protein; Validated; Region: PRK07668 281309011227 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 281309011228 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281309011229 active site residue [active] 281309011230 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309011231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309011232 DNA binding site [nucleotide binding] 281309011233 domain linker motif; other site 281309011234 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 281309011235 putative dimerization interface [polypeptide binding]; other site 281309011236 putative ligand binding site [chemical binding]; other site 281309011237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309011238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309011239 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 281309011240 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 281309011241 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 281309011242 Domain of unknown function (DUF202); Region: DUF202; cl09954 281309011243 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 281309011244 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 281309011245 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 281309011246 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 281309011247 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309011248 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309011249 Walker A/P-loop; other site 281309011250 ATP binding site [chemical binding]; other site 281309011251 Q-loop/lid; other site 281309011252 ABC transporter signature motif; other site 281309011253 Walker B; other site 281309011254 D-loop; other site 281309011255 H-loop/switch region; other site 281309011256 Predicted transcriptional regulators [Transcription]; Region: COG1725 281309011257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309011258 DNA-binding site [nucleotide binding]; DNA binding site 281309011259 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 281309011260 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 281309011261 tetramer interface [polypeptide binding]; other site 281309011262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011263 catalytic residue [active] 281309011264 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 281309011265 tetramer interface [polypeptide binding]; other site 281309011266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011267 catalytic residue [active] 281309011268 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 281309011269 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 281309011270 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 281309011271 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 281309011272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309011273 ATP binding site [chemical binding]; other site 281309011274 putative Mg++ binding site [ion binding]; other site 281309011275 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 281309011276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309011277 nucleotide binding region [chemical binding]; other site 281309011278 ATP-binding site [chemical binding]; other site 281309011279 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 281309011280 YqzE-like protein; Region: YqzE; pfam14038 281309011281 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 281309011282 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 281309011283 ADP binding site [chemical binding]; other site 281309011284 magnesium binding site [ion binding]; other site 281309011285 putative shikimate binding site; other site 281309011286 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 281309011287 ComG operon protein 7; Region: ComGG; pfam14173 281309011288 dihydroorotase; Provisional; Region: PRK04250 281309011289 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 281309011290 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 281309011291 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 281309011292 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 281309011293 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 281309011294 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 281309011295 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 281309011296 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 281309011297 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 281309011298 Walker A motif; other site 281309011299 ATP binding site [chemical binding]; other site 281309011300 Walker B motif; other site 281309011301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309011302 putative DNA binding site [nucleotide binding]; other site 281309011303 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 281309011304 putative Zn2+ binding site [ion binding]; other site 281309011305 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 281309011306 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 281309011307 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 281309011308 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 281309011309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309011310 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 281309011311 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 281309011312 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 281309011313 active site 281309011314 homodimer interface [polypeptide binding]; other site 281309011315 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 281309011316 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 281309011317 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 281309011318 substrate binding pocket [chemical binding]; other site 281309011319 dimer interface [polypeptide binding]; other site 281309011320 inhibitor binding site; inhibition site 281309011321 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 281309011322 B12 binding site [chemical binding]; other site 281309011323 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 281309011324 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 281309011325 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 281309011326 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 281309011327 FAD binding site [chemical binding]; other site 281309011328 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281309011329 homodimer interface [polypeptide binding]; other site 281309011330 substrate-cofactor binding pocket; other site 281309011331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011332 catalytic residue [active] 281309011333 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281309011334 homodimer interface [polypeptide binding]; other site 281309011335 substrate-cofactor binding pocket; other site 281309011336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011337 catalytic residue [active] 281309011338 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 281309011339 catalytic triad [active] 281309011340 conserved cis-peptide bond; other site 281309011341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309011342 dimerization interface [polypeptide binding]; other site 281309011343 putative DNA binding site [nucleotide binding]; other site 281309011344 putative Zn2+ binding site [ion binding]; other site 281309011345 Uncharacterized conserved protein [Function unknown]; Region: COG1565 281309011346 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 281309011347 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 281309011348 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 281309011349 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 281309011350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281309011351 nucleotide binding site [chemical binding]; other site 281309011352 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 281309011353 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 281309011354 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 281309011355 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 281309011356 active site 281309011357 Substrate binding site; other site 281309011358 Mg++ binding site; other site 281309011359 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 281309011360 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 281309011361 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 281309011362 active site 281309011363 metal binding site [ion binding]; metal-binding site 281309011364 substrate binding site [chemical binding]; other site 281309011365 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 281309011366 PhoU domain; Region: PhoU; pfam01895 281309011367 PhoU domain; Region: PhoU; pfam01895 281309011368 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 281309011369 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 281309011370 Walker A/P-loop; other site 281309011371 ATP binding site [chemical binding]; other site 281309011372 Q-loop/lid; other site 281309011373 ABC transporter signature motif; other site 281309011374 Walker B; other site 281309011375 D-loop; other site 281309011376 H-loop/switch region; other site 281309011377 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 281309011378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309011379 dimer interface [polypeptide binding]; other site 281309011380 conserved gate region; other site 281309011381 putative PBP binding loops; other site 281309011382 ABC-ATPase subunit interface; other site 281309011383 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 281309011384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309011385 dimer interface [polypeptide binding]; other site 281309011386 conserved gate region; other site 281309011387 putative PBP binding loops; other site 281309011388 ABC-ATPase subunit interface; other site 281309011389 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 281309011390 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309011391 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309011392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309011393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309011394 putative substrate translocation pore; other site 281309011395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309011396 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 281309011397 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 281309011398 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 281309011399 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 281309011400 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 281309011401 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 281309011402 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 281309011403 metal binding site 2 [ion binding]; metal-binding site 281309011404 putative DNA binding helix; other site 281309011405 metal binding site 1 [ion binding]; metal-binding site 281309011406 dimer interface [polypeptide binding]; other site 281309011407 structural Zn2+ binding site [ion binding]; other site 281309011408 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309011409 ABC-ATPase subunit interface; other site 281309011410 dimer interface [polypeptide binding]; other site 281309011411 putative PBP binding regions; other site 281309011412 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 281309011413 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 281309011414 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309011415 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309011416 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 281309011417 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 281309011418 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 281309011419 AP (apurinic/apyrimidinic) site pocket; other site 281309011420 DNA interaction; other site 281309011421 Metal-binding active site; metal-binding site 281309011422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 281309011423 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281309011424 ATP binding site [chemical binding]; other site 281309011425 Mg++ binding site [ion binding]; other site 281309011426 motif III; other site 281309011427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309011428 nucleotide binding region [chemical binding]; other site 281309011429 ATP-binding site [chemical binding]; other site 281309011430 YqfQ-like protein; Region: YqfQ; pfam14181 281309011431 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 281309011432 Fe-S cluster binding site [ion binding]; other site 281309011433 substrate binding site [chemical binding]; other site 281309011434 catalytic site [active] 281309011435 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 281309011436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 281309011437 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 281309011438 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 281309011439 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 281309011440 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 281309011441 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 281309011442 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 281309011443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309011444 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281309011445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309011446 DNA binding residues [nucleotide binding] 281309011447 DNA primase; Validated; Region: dnaG; PRK05667 281309011448 CHC2 zinc finger; Region: zf-CHC2; pfam01807 281309011449 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 281309011450 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 281309011451 active site 281309011452 metal binding site [ion binding]; metal-binding site 281309011453 interdomain interaction site; other site 281309011454 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 281309011455 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 281309011456 PEP synthetase regulatory protein; Provisional; Region: PRK05339 281309011457 HTH domain; Region: HTH_11; pfam08279 281309011458 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 281309011459 FOG: CBS domain [General function prediction only]; Region: COG0517 281309011460 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 281309011461 Recombination protein O N terminal; Region: RecO_N; pfam11967 281309011462 Recombination protein O C terminal; Region: RecO_C; pfam02565 281309011463 GTPase Era; Reviewed; Region: era; PRK00089 281309011464 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 281309011465 G1 box; other site 281309011466 GTP/Mg2+ binding site [chemical binding]; other site 281309011467 Switch I region; other site 281309011468 G2 box; other site 281309011469 Switch II region; other site 281309011470 G3 box; other site 281309011471 G4 box; other site 281309011472 G5 box; other site 281309011473 KH domain; Region: KH_2; pfam07650 281309011474 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 281309011475 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 281309011476 active site 281309011477 catalytic motif [active] 281309011478 Zn binding site [ion binding]; other site 281309011479 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 281309011480 trimer interface [polypeptide binding]; other site 281309011481 putative active site [active] 281309011482 Zn binding site [ion binding]; other site 281309011483 metal-binding heat shock protein; Provisional; Region: PRK00016 281309011484 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 281309011485 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 281309011486 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 281309011487 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309011488 Zn2+ binding site [ion binding]; other site 281309011489 Mg2+ binding site [ion binding]; other site 281309011490 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 281309011491 PhoH-like protein; Region: PhoH; pfam02562 281309011492 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 281309011493 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 281309011494 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 281309011495 Yqey-like protein; Region: YqeY; pfam09424 281309011496 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 281309011497 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 281309011498 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 281309011499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309011500 FeS/SAM binding site; other site 281309011501 TRAM domain; Region: TRAM; cl01282 281309011502 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 281309011503 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 281309011504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309011505 S-adenosylmethionine binding site [chemical binding]; other site 281309011506 chaperone protein DnaJ; Provisional; Region: PRK14280 281309011507 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 281309011508 HSP70 interaction site [polypeptide binding]; other site 281309011509 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 281309011510 substrate binding site [polypeptide binding]; other site 281309011511 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 281309011512 Zn binding sites [ion binding]; other site 281309011513 dimer interface [polypeptide binding]; other site 281309011514 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 281309011515 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 281309011516 nucleotide binding site [chemical binding]; other site 281309011517 NEF interaction site [polypeptide binding]; other site 281309011518 SBD interface [polypeptide binding]; other site 281309011519 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 281309011520 dimer interface [polypeptide binding]; other site 281309011521 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 281309011522 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 281309011523 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 281309011524 HrcA protein C terminal domain; Region: HrcA; pfam01628 281309011525 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 281309011526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309011527 FeS/SAM binding site; other site 281309011528 HemN C-terminal domain; Region: HemN_C; pfam06969 281309011529 Predicted transcriptional regulators [Transcription]; Region: COG1733 281309011530 dimerization interface [polypeptide binding]; other site 281309011531 putative DNA binding site [nucleotide binding]; other site 281309011532 putative Zn2+ binding site [ion binding]; other site 281309011533 GTP-binding protein LepA; Provisional; Region: PRK05433 281309011534 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 281309011535 G1 box; other site 281309011536 putative GEF interaction site [polypeptide binding]; other site 281309011537 GTP/Mg2+ binding site [chemical binding]; other site 281309011538 Switch I region; other site 281309011539 G2 box; other site 281309011540 G3 box; other site 281309011541 Switch II region; other site 281309011542 G4 box; other site 281309011543 G5 box; other site 281309011544 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 281309011545 Elongation Factor G, domain II; Region: EFG_II; pfam14492 281309011546 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 281309011547 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 281309011548 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 281309011549 germination protease; Provisional; Region: PRK02858 281309011550 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 281309011551 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 281309011552 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 281309011553 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 281309011554 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 281309011555 Competence protein; Region: Competence; pfam03772 281309011556 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309011557 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 281309011558 catalytic motif [active] 281309011559 Zn binding site [ion binding]; other site 281309011560 SLBB domain; Region: SLBB; pfam10531 281309011561 comEA protein; Region: comE; TIGR01259 281309011562 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 281309011563 late competence protein ComER; Validated; Region: PRK07680 281309011564 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 281309011565 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 281309011566 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 281309011567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309011568 S-adenosylmethionine binding site [chemical binding]; other site 281309011569 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 281309011570 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 281309011571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309011572 Zn2+ binding site [ion binding]; other site 281309011573 Mg2+ binding site [ion binding]; other site 281309011574 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 281309011575 active site 281309011576 (T/H)XGH motif; other site 281309011577 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 281309011578 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 281309011579 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 281309011580 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 281309011581 shikimate binding site; other site 281309011582 NAD(P) binding site [chemical binding]; other site 281309011583 GTPase YqeH; Provisional; Region: PRK13796 281309011584 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 281309011585 GTP/Mg2+ binding site [chemical binding]; other site 281309011586 G4 box; other site 281309011587 G5 box; other site 281309011588 G1 box; other site 281309011589 Switch I region; other site 281309011590 G2 box; other site 281309011591 G3 box; other site 281309011592 Switch II region; other site 281309011593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309011594 active site 281309011595 motif I; other site 281309011596 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 281309011597 motif II; other site 281309011598 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 281309011599 sporulation sigma factor SigK; Reviewed; Region: PRK05803 281309011600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309011601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309011602 DNA binding residues [nucleotide binding] 281309011603 germination protein YpeB; Region: spore_YpeB; TIGR02889 281309011604 Transposase; Region: HTH_Tnp_1; cl17663 281309011605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281309011606 HTH-like domain; Region: HTH_21; pfam13276 281309011607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 281309011608 Integrase core domain; Region: rve; pfam00665 281309011609 Integrase core domain; Region: rve_2; pfam13333 281309011610 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 281309011611 dimer interface [polypeptide binding]; other site 281309011612 FMN binding site [chemical binding]; other site 281309011613 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 281309011614 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 281309011615 synthetase active site [active] 281309011616 NTP binding site [chemical binding]; other site 281309011617 metal binding site [ion binding]; metal-binding site 281309011618 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 281309011619 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 281309011620 dimer interface [polypeptide binding]; other site 281309011621 active site 281309011622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309011623 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 281309011624 Coenzyme A binding pocket [chemical binding]; other site 281309011625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309011626 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309011627 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309011628 Predicted membrane protein [Function unknown]; Region: COG2259 281309011629 CHAT domain; Region: CHAT; cl19248 281309011630 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 281309011631 catalytic core [active] 281309011632 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 281309011633 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 281309011634 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 281309011635 Subtilase family; Region: Peptidase_S8; pfam00082 281309011636 catalytic triad [active] 281309011637 putative active site [active] 281309011638 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 281309011639 PA/protease or protease-like domain interface [polypeptide binding]; other site 281309011640 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 281309011641 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 281309011642 cofactor binding site; other site 281309011643 metal binding site [ion binding]; metal-binding site 281309011644 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 281309011645 aromatic arch; other site 281309011646 DCoH dimer interaction site [polypeptide binding]; other site 281309011647 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 281309011648 DCoH tetramer interaction site [polypeptide binding]; other site 281309011649 substrate binding site [chemical binding]; other site 281309011650 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 281309011651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 281309011652 putative metal binding site [ion binding]; other site 281309011653 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 281309011654 active site 281309011655 metal binding site [ion binding]; metal-binding site 281309011656 Predicted membrane protein [Function unknown]; Region: COG2259 281309011657 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 281309011658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309011659 non-specific DNA binding site [nucleotide binding]; other site 281309011660 salt bridge; other site 281309011661 sequence-specific DNA binding site [nucleotide binding]; other site 281309011662 Cupin domain; Region: Cupin_2; pfam07883 281309011663 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 281309011664 active site 2 [active] 281309011665 active site 1 [active] 281309011666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309011667 Coenzyme A binding pocket [chemical binding]; other site 281309011668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309011669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309011670 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309011671 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281309011672 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281309011673 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281309011674 Walker A/P-loop; other site 281309011675 ATP binding site [chemical binding]; other site 281309011676 Q-loop/lid; other site 281309011677 ABC transporter signature motif; other site 281309011678 Walker B; other site 281309011679 D-loop; other site 281309011680 H-loop/switch region; other site 281309011681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309011682 ABC-ATPase subunit interface; other site 281309011683 dimer interface [polypeptide binding]; other site 281309011684 putative PBP binding regions; other site 281309011685 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 281309011686 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309011687 intersubunit interface [polypeptide binding]; other site 281309011688 YrhC-like protein; Region: YrhC; pfam14143 281309011689 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 281309011690 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 281309011691 putative catalytic cysteine [active] 281309011692 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 281309011693 putative active site [active] 281309011694 metal binding site [ion binding]; metal-binding site 281309011695 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281309011696 homodimer interface [polypeptide binding]; other site 281309011697 substrate-cofactor binding pocket; other site 281309011698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011699 catalytic residue [active] 281309011700 cysteine synthase; Region: PLN02565 281309011701 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 281309011702 dimer interface [polypeptide binding]; other site 281309011703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011704 catalytic residue [active] 281309011705 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 281309011706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309011707 S-adenosylmethionine binding site [chemical binding]; other site 281309011708 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 281309011709 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 281309011710 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281309011711 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 281309011712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281309011713 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 281309011714 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 281309011715 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 281309011716 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 281309011717 ATP-binding site [chemical binding]; other site 281309011718 Sugar specificity; other site 281309011719 Pyrimidine base specificity; other site 281309011720 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 281309011721 putative protease; Provisional; Region: PRK15452 281309011722 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 281309011723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309011724 S-adenosylmethionine binding site [chemical binding]; other site 281309011725 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 281309011726 dimerization interface [polypeptide binding]; other site 281309011727 hypothetical protein; Provisional; Region: PRK13678 281309011728 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 281309011729 hypothetical protein; Provisional; Region: PRK05473 281309011730 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 281309011731 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 281309011732 motif 1; other site 281309011733 active site 281309011734 motif 2; other site 281309011735 motif 3; other site 281309011736 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 281309011737 DHHA1 domain; Region: DHHA1; pfam02272 281309011738 Bacterial PH domain; Region: bPH_3; pfam14470 281309011739 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281309011740 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 281309011741 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 281309011742 AAA domain; Region: AAA_30; pfam13604 281309011743 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 281309011744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309011745 TPR motif; other site 281309011746 TPR repeat; Region: TPR_11; pfam13414 281309011747 binding surface 281309011748 TPR repeat; Region: TPR_11; pfam13414 281309011749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309011750 binding surface 281309011751 TPR motif; other site 281309011752 TPR repeat; Region: TPR_11; pfam13414 281309011753 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 281309011754 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 281309011755 Ligand Binding Site [chemical binding]; other site 281309011756 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 281309011757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309011758 catalytic residue [active] 281309011759 Predicted transcriptional regulator [Transcription]; Region: COG1959 281309011760 Rrf2 family protein; Region: rrf2_super; TIGR00738 281309011761 recombination factor protein RarA; Reviewed; Region: PRK13342 281309011762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309011763 Walker A motif; other site 281309011764 ATP binding site [chemical binding]; other site 281309011765 Walker B motif; other site 281309011766 arginine finger; other site 281309011767 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 281309011768 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 281309011769 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 281309011770 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 281309011771 putative ATP binding site [chemical binding]; other site 281309011772 putative substrate interface [chemical binding]; other site 281309011773 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 281309011774 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 281309011775 dimer interface [polypeptide binding]; other site 281309011776 anticodon binding site; other site 281309011777 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 281309011778 homodimer interface [polypeptide binding]; other site 281309011779 motif 1; other site 281309011780 active site 281309011781 motif 2; other site 281309011782 GAD domain; Region: GAD; pfam02938 281309011783 motif 3; other site 281309011784 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 281309011785 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 281309011786 dimer interface [polypeptide binding]; other site 281309011787 motif 1; other site 281309011788 active site 281309011789 motif 2; other site 281309011790 motif 3; other site 281309011791 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 281309011792 anticodon binding site; other site 281309011793 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 281309011794 putative active site [active] 281309011795 dimerization interface [polypeptide binding]; other site 281309011796 putative tRNAtyr binding site [nucleotide binding]; other site 281309011797 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 281309011798 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309011799 Zn2+ binding site [ion binding]; other site 281309011800 Mg2+ binding site [ion binding]; other site 281309011801 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 281309011802 synthetase active site [active] 281309011803 NTP binding site [chemical binding]; other site 281309011804 metal binding site [ion binding]; metal-binding site 281309011805 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 281309011806 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 281309011807 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309011808 active site 281309011809 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 281309011810 DHH family; Region: DHH; pfam01368 281309011811 DHHA1 domain; Region: DHHA1; pfam02272 281309011812 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 281309011813 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 281309011814 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 281309011815 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 281309011816 MMPL family; Region: MMPL; cl14618 281309011817 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 281309011818 Protein export membrane protein; Region: SecD_SecF; pfam02355 281309011819 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 281309011820 stage V sporulation protein B; Region: spore_V_B; TIGR02900 281309011821 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 281309011822 Predicted membrane protein [Function unknown]; Region: COG2323 281309011823 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 281309011824 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 281309011825 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 281309011826 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 281309011827 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 281309011828 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 281309011829 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 281309011830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309011831 Walker A motif; other site 281309011832 ATP binding site [chemical binding]; other site 281309011833 Walker B motif; other site 281309011834 arginine finger; other site 281309011835 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 281309011836 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 281309011837 RuvA N terminal domain; Region: RuvA_N; pfam01330 281309011838 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 281309011839 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 281309011840 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309011841 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 281309011842 putative ligand binding residues [chemical binding]; other site 281309011843 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 281309011844 BofC C-terminal domain; Region: BofC_C; pfam08955 281309011845 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309011846 EamA-like transporter family; Region: EamA; pfam00892 281309011847 EamA-like transporter family; Region: EamA; pfam00892 281309011848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309011849 dimerization interface [polypeptide binding]; other site 281309011850 putative DNA binding site [nucleotide binding]; other site 281309011851 putative Zn2+ binding site [ion binding]; other site 281309011852 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 281309011853 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309011854 quinolinate synthetase; Provisional; Region: PRK09375 281309011855 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 281309011856 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 281309011857 dimerization interface [polypeptide binding]; other site 281309011858 active site 281309011859 L-aspartate oxidase; Provisional; Region: PRK08071 281309011860 L-aspartate oxidase; Provisional; Region: PRK06175 281309011861 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 281309011862 cysteine desulfurase; Provisional; Region: PRK02948 281309011863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309011864 catalytic residue [active] 281309011865 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 281309011866 HTH domain; Region: HTH_11; pfam08279 281309011867 3H domain; Region: 3H; pfam02829 281309011868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 281309011869 MOSC domain; Region: MOSC; pfam03473 281309011870 3-alpha domain; Region: 3-alpha; pfam03475 281309011871 prephenate dehydratase; Provisional; Region: PRK11898 281309011872 Prephenate dehydratase; Region: PDT; pfam00800 281309011873 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 281309011874 putative L-Phe binding site [chemical binding]; other site 281309011875 FtsX-like permease family; Region: FtsX; pfam02687 281309011876 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309011877 FtsX-like permease family; Region: FtsX; pfam02687 281309011878 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309011879 FtsX-like permease family; Region: FtsX; pfam02687 281309011880 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309011881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309011882 Walker A/P-loop; other site 281309011883 ATP binding site [chemical binding]; other site 281309011884 Q-loop/lid; other site 281309011885 ABC transporter signature motif; other site 281309011886 Walker B; other site 281309011887 D-loop; other site 281309011888 H-loop/switch region; other site 281309011889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309011890 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 281309011891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309011892 ATP binding site [chemical binding]; other site 281309011893 Mg2+ binding site [ion binding]; other site 281309011894 G-X-G motif; other site 281309011895 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309011896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309011897 active site 281309011898 phosphorylation site [posttranslational modification] 281309011899 intermolecular recognition site; other site 281309011900 dimerization interface [polypeptide binding]; other site 281309011901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309011902 DNA binding site [nucleotide binding] 281309011903 GTPase CgtA; Reviewed; Region: obgE; PRK12297 281309011904 GTP1/OBG; Region: GTP1_OBG; pfam01018 281309011905 Obg GTPase; Region: Obg; cd01898 281309011906 G1 box; other site 281309011907 GTP/Mg2+ binding site [chemical binding]; other site 281309011908 Switch I region; other site 281309011909 G2 box; other site 281309011910 G3 box; other site 281309011911 Switch II region; other site 281309011912 G4 box; other site 281309011913 G5 box; other site 281309011914 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 281309011915 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 281309011916 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 281309011917 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 281309011918 hypothetical protein; Provisional; Region: PRK14553 281309011919 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 281309011920 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 281309011921 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 281309011922 homodimer interface [polypeptide binding]; other site 281309011923 oligonucleotide binding site [chemical binding]; other site 281309011924 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 281309011925 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 281309011926 Peptidase family M50; Region: Peptidase_M50; pfam02163 281309011927 active site 281309011928 putative substrate binding region [chemical binding]; other site 281309011929 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309011930 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309011931 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 281309011932 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 281309011933 P-loop; other site 281309011934 ADP binding residues [chemical binding]; other site 281309011935 Switch I; other site 281309011936 Switch II; other site 281309011937 septum formation inhibitor; Reviewed; Region: minC; PRK00513 281309011938 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 281309011939 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 281309011940 rod shape-determining protein MreC; Provisional; Region: PRK13922 281309011941 rod shape-determining protein MreB; Provisional; Region: PRK13927 281309011942 MreB and similar proteins; Region: MreB_like; cd10225 281309011943 nucleotide binding site [chemical binding]; other site 281309011944 Mg binding site [ion binding]; other site 281309011945 putative protofilament interaction site [polypeptide binding]; other site 281309011946 RodZ interaction site [polypeptide binding]; other site 281309011947 hypothetical protein; Reviewed; Region: PRK00024 281309011948 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 281309011949 MPN+ (JAMM) motif; other site 281309011950 Zinc-binding site [ion binding]; other site 281309011951 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 281309011952 active site 281309011953 dimer interface [polypeptide binding]; other site 281309011954 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 281309011955 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309011956 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309011957 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 281309011958 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 281309011959 active site 281309011960 HIGH motif; other site 281309011961 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 281309011962 KMSKS motif; other site 281309011963 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 281309011964 tRNA binding surface [nucleotide binding]; other site 281309011965 anticodon binding site; other site 281309011966 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 281309011967 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 281309011968 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 281309011969 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281309011970 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 281309011971 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281309011972 inhibitor-cofactor binding pocket; inhibition site 281309011973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309011974 catalytic residue [active] 281309011975 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 281309011976 dimer interface [polypeptide binding]; other site 281309011977 active site 281309011978 Schiff base residues; other site 281309011979 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 281309011980 active site 281309011981 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 281309011982 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 281309011983 domain interfaces; other site 281309011984 active site 281309011985 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 281309011986 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 281309011987 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 281309011988 tRNA; other site 281309011989 putative tRNA binding site [nucleotide binding]; other site 281309011990 putative NADP binding site [chemical binding]; other site 281309011991 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 281309011992 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309011993 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309011994 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 281309011995 Predicted GTPase [General function prediction only]; Region: COG0218 281309011996 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 281309011997 G1 box; other site 281309011998 GTP/Mg2+ binding site [chemical binding]; other site 281309011999 Switch I region; other site 281309012000 G2 box; other site 281309012001 G3 box; other site 281309012002 Switch II region; other site 281309012003 G4 box; other site 281309012004 G5 box; other site 281309012005 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 281309012006 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 281309012007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309012008 Walker A motif; other site 281309012009 ATP binding site [chemical binding]; other site 281309012010 Walker B motif; other site 281309012011 arginine finger; other site 281309012012 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 281309012013 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 281309012014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309012015 Walker A motif; other site 281309012016 ATP binding site [chemical binding]; other site 281309012017 Walker B motif; other site 281309012018 arginine finger; other site 281309012019 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 281309012020 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 281309012021 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 281309012022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309012023 Walker A motif; other site 281309012024 ATP binding site [chemical binding]; other site 281309012025 Walker B motif; other site 281309012026 arginine finger; other site 281309012027 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 281309012028 trigger factor; Provisional; Region: tig; PRK01490 281309012029 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 281309012030 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 281309012031 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 281309012032 PD-(D/E)XK endonuclease; Region: PDDEXK_5; pfam11645 281309012033 Bacterial PH domain; Region: bPH_1; pfam08000 281309012034 YvbH-like oligomerization region; Region: YvbH_ext; pfam11724 281309012035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309012036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309012037 TPR motif; other site 281309012038 binding surface 281309012039 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 281309012040 active site 281309012041 metal binding site [ion binding]; metal-binding site 281309012042 homotetramer interface [polypeptide binding]; other site 281309012043 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 281309012044 active site 281309012045 dimerization interface [polypeptide binding]; other site 281309012046 ribonuclease PH; Reviewed; Region: rph; PRK00173 281309012047 Ribonuclease PH; Region: RNase_PH_bact; cd11362 281309012048 hexamer interface [polypeptide binding]; other site 281309012049 active site 281309012050 Spore germination protein [General function prediction only]; Region: COG5401 281309012051 Sporulation and spore germination; Region: Germane; pfam10646 281309012052 Sporulation and spore germination; Region: Germane; pfam10646 281309012053 glutamate racemase; Provisional; Region: PRK00865 281309012054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309012055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309012056 putative substrate translocation pore; other site 281309012057 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 281309012058 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 281309012059 potential catalytic triad [active] 281309012060 conserved cys residue [active] 281309012061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309012062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309012063 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 281309012064 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 281309012065 potential catalytic triad [active] 281309012066 conserved cys residue [active] 281309012067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309012068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309012069 DNA binding residues [nucleotide binding] 281309012070 dimerization interface [polypeptide binding]; other site 281309012071 Sulfate transporter family; Region: Sulfate_transp; cl19250 281309012072 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 281309012073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309012074 EamA-like transporter family; Region: EamA; pfam00892 281309012075 EamA-like transporter family; Region: EamA; pfam00892 281309012076 cytosine deaminase; Provisional; Region: PRK05985 281309012077 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 281309012078 active site 281309012079 cytosine deaminase; Provisional; Region: PRK05985 281309012080 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 281309012081 active site 281309012082 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 281309012083 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 281309012084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281309012085 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 281309012086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309012087 dimer interface [polypeptide binding]; other site 281309012088 conserved gate region; other site 281309012089 putative PBP binding loops; other site 281309012090 ABC-ATPase subunit interface; other site 281309012091 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281309012092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309012093 dimer interface [polypeptide binding]; other site 281309012094 conserved gate region; other site 281309012095 putative PBP binding loops; other site 281309012096 ABC-ATPase subunit interface; other site 281309012097 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 281309012098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309012099 Walker A/P-loop; other site 281309012100 ATP binding site [chemical binding]; other site 281309012101 Q-loop/lid; other site 281309012102 ABC transporter signature motif; other site 281309012103 Walker B; other site 281309012104 D-loop; other site 281309012105 H-loop/switch region; other site 281309012106 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309012107 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 281309012108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281309012109 Walker A/P-loop; other site 281309012110 ATP binding site [chemical binding]; other site 281309012111 Q-loop/lid; other site 281309012112 ABC transporter signature motif; other site 281309012113 Walker B; other site 281309012114 D-loop; other site 281309012115 H-loop/switch region; other site 281309012116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281309012117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 281309012118 Histidine kinase; Region: His_kinase; pfam06580 281309012119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309012120 ATP binding site [chemical binding]; other site 281309012121 Mg2+ binding site [ion binding]; other site 281309012122 G-X-G motif; other site 281309012123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309012124 active site 281309012125 phosphorylation site [posttranslational modification] 281309012126 intermolecular recognition site; other site 281309012127 dimerization interface [polypeptide binding]; other site 281309012128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309012129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 281309012130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309012131 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 281309012132 Na binding site [ion binding]; other site 281309012133 PspC domain; Region: PspC; pfam04024 281309012134 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 281309012135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309012136 non-specific DNA binding site [nucleotide binding]; other site 281309012137 salt bridge; other site 281309012138 sequence-specific DNA binding site [nucleotide binding]; other site 281309012139 Cupin domain; Region: Cupin_2; pfam07883 281309012140 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 281309012141 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 281309012142 amphipathic channel; other site 281309012143 Asn-Pro-Ala signature motifs; other site 281309012144 Predicted transcriptional regulator [Transcription]; Region: COG1959 281309012145 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 281309012146 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 281309012147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309012148 Walker A/P-loop; other site 281309012149 ATP binding site [chemical binding]; other site 281309012150 Q-loop/lid; other site 281309012151 ABC transporter signature motif; other site 281309012152 Walker B; other site 281309012153 D-loop; other site 281309012154 H-loop/switch region; other site 281309012155 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 281309012156 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 281309012157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309012158 active site 281309012159 motif I; other site 281309012160 motif II; other site 281309012161 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 281309012162 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 281309012163 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 281309012164 ligand binding site [chemical binding]; other site 281309012165 flagellar motor protein MotA; Validated; Region: PRK08124 281309012166 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 281309012167 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 281309012168 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 281309012169 active site 281309012170 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 281309012171 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 281309012172 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 281309012173 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 281309012174 L-aspartate oxidase; Provisional; Region: PRK06175 281309012175 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 281309012176 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 281309012177 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 281309012178 putative Iron-sulfur protein interface [polypeptide binding]; other site 281309012179 proximal heme binding site [chemical binding]; other site 281309012180 distal heme binding site [chemical binding]; other site 281309012181 putative dimer interface [polypeptide binding]; other site 281309012182 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 281309012183 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 281309012184 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 281309012185 GIY-YIG motif/motif A; other site 281309012186 active site 281309012187 catalytic site [active] 281309012188 putative DNA binding site [nucleotide binding]; other site 281309012189 metal binding site [ion binding]; metal-binding site 281309012190 Cytochrome P450; Region: p450; cl12078 281309012191 UvrB/uvrC motif; Region: UVR; pfam02151 281309012192 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 281309012193 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 281309012194 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281309012195 catalytic residues [active] 281309012196 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 281309012197 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 281309012198 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 281309012199 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 281309012200 Ligand binding site [chemical binding]; other site 281309012201 enoyl-CoA hydratase; Provisional; Region: PRK07658 281309012202 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309012203 substrate binding site [chemical binding]; other site 281309012204 oxyanion hole (OAH) forming residues; other site 281309012205 trimer interface [polypeptide binding]; other site 281309012206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309012207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309012208 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 281309012209 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 281309012210 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 281309012211 acyl-activating enzyme (AAE) consensus motif; other site 281309012212 putative AMP binding site [chemical binding]; other site 281309012213 putative active site [active] 281309012214 putative CoA binding site [chemical binding]; other site 281309012215 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309012216 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 281309012217 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 281309012218 siderophore binding site; other site 281309012219 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 281309012220 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309012221 ABC-ATPase subunit interface; other site 281309012222 dimer interface [polypeptide binding]; other site 281309012223 putative PBP binding regions; other site 281309012224 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309012225 ABC-ATPase subunit interface; other site 281309012226 dimer interface [polypeptide binding]; other site 281309012227 putative PBP binding regions; other site 281309012228 DinB family; Region: DinB; cl17821 281309012229 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281309012230 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 281309012231 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 281309012232 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 281309012233 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281309012234 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309012235 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 281309012236 Walker A/P-loop; other site 281309012237 ATP binding site [chemical binding]; other site 281309012238 Q-loop/lid; other site 281309012239 ABC transporter signature motif; other site 281309012240 Walker B; other site 281309012241 D-loop; other site 281309012242 H-loop/switch region; other site 281309012243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309012244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309012245 dimer interface [polypeptide binding]; other site 281309012246 phosphorylation site [posttranslational modification] 281309012247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309012248 ATP binding site [chemical binding]; other site 281309012249 Mg2+ binding site [ion binding]; other site 281309012250 G-X-G motif; other site 281309012251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309012252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309012253 active site 281309012254 phosphorylation site [posttranslational modification] 281309012255 intermolecular recognition site; other site 281309012256 dimerization interface [polypeptide binding]; other site 281309012257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309012258 DNA binding site [nucleotide binding] 281309012259 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 281309012260 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 281309012261 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 281309012262 putative RNA binding site [nucleotide binding]; other site 281309012263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 281309012264 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 281309012265 TrkA-N domain; Region: TrkA_N; pfam02254 281309012266 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 281309012267 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 281309012268 active site 281309012269 catalytic site [active] 281309012270 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281309012271 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281309012272 Walker A/P-loop; other site 281309012273 ATP binding site [chemical binding]; other site 281309012274 Q-loop/lid; other site 281309012275 ABC transporter signature motif; other site 281309012276 Walker B; other site 281309012277 D-loop; other site 281309012278 H-loop/switch region; other site 281309012279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309012280 ABC-ATPase subunit interface; other site 281309012281 dimer interface [polypeptide binding]; other site 281309012282 putative PBP binding regions; other site 281309012283 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 281309012284 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309012285 intersubunit interface [polypeptide binding]; other site 281309012286 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309012287 heme-binding site [chemical binding]; other site 281309012288 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309012289 heme-binding site [chemical binding]; other site 281309012290 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 281309012291 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 281309012292 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309012293 heme-binding site [chemical binding]; other site 281309012294 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309012295 heme-binding site [chemical binding]; other site 281309012296 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309012297 heme-binding site [chemical binding]; other site 281309012298 heme uptake protein IsdC; Region: IsdC; TIGR03656 281309012299 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 281309012300 heme-binding site [chemical binding]; other site 281309012301 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 281309012302 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 281309012303 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 281309012304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309012305 RNA binding surface [nucleotide binding]; other site 281309012306 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 281309012307 probable active site [active] 281309012308 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 281309012309 MutS domain III; Region: MutS_III; pfam05192 281309012310 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 281309012311 Walker A/P-loop; other site 281309012312 ATP binding site [chemical binding]; other site 281309012313 Q-loop/lid; other site 281309012314 ABC transporter signature motif; other site 281309012315 Walker B; other site 281309012316 D-loop; other site 281309012317 H-loop/switch region; other site 281309012318 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 281309012319 Smr domain; Region: Smr; pfam01713 281309012320 hypothetical protein; Provisional; Region: PRK08609 281309012321 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 281309012322 active site 281309012323 primer binding site [nucleotide binding]; other site 281309012324 NTP binding site [chemical binding]; other site 281309012325 metal binding triad [ion binding]; metal-binding site 281309012326 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 281309012327 active site 281309012328 Colicin V production protein; Region: Colicin_V; pfam02674 281309012329 cell division protein ZapA; Provisional; Region: PRK14126 281309012330 ribonuclease HIII; Provisional; Region: PRK00996 281309012331 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 281309012332 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 281309012333 RNA/DNA hybrid binding site [nucleotide binding]; other site 281309012334 active site 281309012335 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 281309012336 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 281309012337 putative dimer interface [polypeptide binding]; other site 281309012338 putative anticodon binding site; other site 281309012339 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 281309012340 homodimer interface [polypeptide binding]; other site 281309012341 motif 1; other site 281309012342 motif 2; other site 281309012343 active site 281309012344 motif 3; other site 281309012345 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 281309012346 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 281309012347 putative tRNA-binding site [nucleotide binding]; other site 281309012348 B3/4 domain; Region: B3_4; pfam03483 281309012349 tRNA synthetase B5 domain; Region: B5; smart00874 281309012350 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 281309012351 dimer interface [polypeptide binding]; other site 281309012352 motif 1; other site 281309012353 motif 3; other site 281309012354 motif 2; other site 281309012355 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 281309012356 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 281309012357 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 281309012358 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 281309012359 dimer interface [polypeptide binding]; other site 281309012360 motif 1; other site 281309012361 active site 281309012362 motif 2; other site 281309012363 motif 3; other site 281309012364 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 281309012365 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 281309012366 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 281309012367 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 281309012368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309012369 Zn2+ binding site [ion binding]; other site 281309012370 Mg2+ binding site [ion binding]; other site 281309012371 CAAX protease self-immunity; Region: Abi; pfam02517 281309012372 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 281309012373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309012374 putative substrate translocation pore; other site 281309012375 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 281309012376 HlyD family secretion protein; Region: HlyD_3; pfam13437 281309012377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309012378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309012379 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 281309012380 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 281309012381 oligomer interface [polypeptide binding]; other site 281309012382 active site 281309012383 metal binding site [ion binding]; metal-binding site 281309012384 dUTPase; Region: dUTPase_2; pfam08761 281309012385 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 281309012386 active site 281309012387 homodimer interface [polypeptide binding]; other site 281309012388 metal binding site [ion binding]; metal-binding site 281309012389 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 281309012390 23S rRNA binding site [nucleotide binding]; other site 281309012391 L21 binding site [polypeptide binding]; other site 281309012392 L13 binding site [polypeptide binding]; other site 281309012393 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 281309012394 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 281309012395 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 281309012396 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 281309012397 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 281309012398 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 281309012399 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 281309012400 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 281309012401 active site 281309012402 dimer interface [polypeptide binding]; other site 281309012403 motif 1; other site 281309012404 motif 2; other site 281309012405 motif 3; other site 281309012406 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 281309012407 anticodon binding site; other site 281309012408 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 281309012409 primosomal protein DnaI; Reviewed; Region: PRK08939 281309012410 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 281309012411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 281309012412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309012413 Walker A motif; other site 281309012414 ATP binding site [chemical binding]; other site 281309012415 Walker B motif; other site 281309012416 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 281309012417 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 281309012418 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 281309012419 ATP cone domain; Region: ATP-cone; pfam03477 281309012420 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 281309012421 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 281309012422 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 281309012423 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 281309012424 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 281309012425 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 281309012426 CoA-binding site [chemical binding]; other site 281309012427 ATP-binding [chemical binding]; other site 281309012428 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 281309012429 Domain of unknown function DUF; Region: DUF204; pfam02659 281309012430 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 281309012431 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 281309012432 DNA binding site [nucleotide binding] 281309012433 catalytic residue [active] 281309012434 H2TH interface [polypeptide binding]; other site 281309012435 putative catalytic residues [active] 281309012436 turnover-facilitating residue; other site 281309012437 intercalation triad [nucleotide binding]; other site 281309012438 8OG recognition residue [nucleotide binding]; other site 281309012439 putative reading head residues; other site 281309012440 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 281309012441 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 281309012442 DNA polymerase I; Provisional; Region: PRK05755 281309012443 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 281309012444 active site 281309012445 metal binding site 1 [ion binding]; metal-binding site 281309012446 putative 5' ssDNA interaction site; other site 281309012447 metal binding site 3; metal-binding site 281309012448 metal binding site 2 [ion binding]; metal-binding site 281309012449 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 281309012450 putative DNA binding site [nucleotide binding]; other site 281309012451 putative metal binding site [ion binding]; other site 281309012452 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 281309012453 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 281309012454 active site 281309012455 DNA binding site [nucleotide binding] 281309012456 catalytic site [active] 281309012457 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 281309012458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309012459 dimerization interface [polypeptide binding]; other site 281309012460 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 281309012461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309012462 putative active site [active] 281309012463 heme pocket [chemical binding]; other site 281309012464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309012465 dimer interface [polypeptide binding]; other site 281309012466 phosphorylation site [posttranslational modification] 281309012467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309012468 ATP binding site [chemical binding]; other site 281309012469 Mg2+ binding site [ion binding]; other site 281309012470 G-X-G motif; other site 281309012471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309012472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309012473 active site 281309012474 phosphorylation site [posttranslational modification] 281309012475 intermolecular recognition site; other site 281309012476 dimerization interface [polypeptide binding]; other site 281309012477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309012478 DNA binding site [nucleotide binding] 281309012479 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 281309012480 active site 2 [active] 281309012481 active site 1 [active] 281309012482 malate dehydrogenase; Reviewed; Region: PRK06223 281309012483 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 281309012484 NAD(P) binding site [chemical binding]; other site 281309012485 dimer interface [polypeptide binding]; other site 281309012486 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309012487 substrate binding site [chemical binding]; other site 281309012488 isocitrate dehydrogenase; Reviewed; Region: PRK07006 281309012489 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 281309012490 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 281309012491 dimer interface [polypeptide binding]; other site 281309012492 active site 281309012493 citrylCoA binding site [chemical binding]; other site 281309012494 oxalacetate/citrate binding site [chemical binding]; other site 281309012495 coenzyme A binding site [chemical binding]; other site 281309012496 catalytic triad [active] 281309012497 Protein of unknown function (DUF441); Region: DUF441; pfam04284 281309012498 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 281309012499 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 281309012500 pyruvate kinase; Provisional; Region: PRK06354 281309012501 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 281309012502 domain interfaces; other site 281309012503 active site 281309012504 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 281309012505 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 281309012506 active site 281309012507 ADP/pyrophosphate binding site [chemical binding]; other site 281309012508 dimerization interface [polypeptide binding]; other site 281309012509 allosteric effector site; other site 281309012510 fructose-1,6-bisphosphate binding site; other site 281309012511 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 281309012512 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 281309012513 Transcriptional regulators [Transcription]; Region: FadR; COG2186 281309012514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309012515 DNA-binding site [nucleotide binding]; DNA binding site 281309012516 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 281309012517 Malic enzyme, N-terminal domain; Region: malic; pfam00390 281309012518 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 281309012519 putative NAD(P) binding site [chemical binding]; other site 281309012520 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 281309012521 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 281309012522 active site 281309012523 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 281309012524 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 281309012525 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 281309012526 generic binding surface II; other site 281309012527 generic binding surface I; other site 281309012528 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 281309012529 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 281309012530 DHH family; Region: DHH; pfam01368 281309012531 DHHA1 domain; Region: DHHA1; pfam02272 281309012532 YtpI-like protein; Region: YtpI; pfam14007 281309012533 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 281309012534 Phosphotransferase enzyme family; Region: APH; pfam01636 281309012535 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 281309012536 active site 281309012537 substrate binding site [chemical binding]; other site 281309012538 ATP binding site [chemical binding]; other site 281309012539 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309012540 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 281309012541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 281309012542 DNA-binding site [nucleotide binding]; DNA binding site 281309012543 DRTGG domain; Region: DRTGG; pfam07085 281309012544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 281309012545 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 281309012546 active site 2 [active] 281309012547 active site 1 [active] 281309012548 metal-dependent hydrolase; Provisional; Region: PRK00685 281309012549 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 281309012550 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 281309012551 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 281309012552 active site 281309012553 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309012554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309012555 Transposase domain (DUF772); Region: DUF772; pfam05598 281309012556 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309012557 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 281309012558 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 281309012559 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 281309012560 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 281309012561 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 281309012562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309012563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309012564 DNA binding residues [nucleotide binding] 281309012565 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 281309012566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309012567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309012568 Coenzyme A binding pocket [chemical binding]; other site 281309012569 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 281309012570 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 281309012571 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 281309012572 hexamer interface [polypeptide binding]; other site 281309012573 ligand binding site [chemical binding]; other site 281309012574 putative active site [active] 281309012575 NAD(P) binding site [chemical binding]; other site 281309012576 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 281309012577 classical (c) SDRs; Region: SDR_c; cd05233 281309012578 NAD(P) binding site [chemical binding]; other site 281309012579 active site 281309012580 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 281309012581 Ligand Binding Site [chemical binding]; other site 281309012582 DinB superfamily; Region: DinB_2; pfam12867 281309012583 argininosuccinate lyase; Provisional; Region: PRK00855 281309012584 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 281309012585 active sites [active] 281309012586 tetramer interface [polypeptide binding]; other site 281309012587 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 281309012588 ANP binding site [chemical binding]; other site 281309012589 Substrate Binding Site II [chemical binding]; other site 281309012590 Substrate Binding Site I [chemical binding]; other site 281309012591 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309012592 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309012593 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309012594 EcsC protein family; Region: EcsC; pfam12787 281309012595 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 281309012596 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 281309012597 nudix motif; other site 281309012598 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 281309012599 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 281309012600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309012601 S-adenosylmethionine binding site [chemical binding]; other site 281309012602 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 281309012603 dimer interface [polypeptide binding]; other site 281309012604 catalytic triad [active] 281309012605 peroxidatic and resolving cysteines [active] 281309012606 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 281309012607 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 281309012608 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 281309012609 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 281309012610 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 281309012611 active site 281309012612 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 281309012613 dimer interface [polypeptide binding]; other site 281309012614 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 281309012615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309012616 acyl-activating enzyme (AAE) consensus motif; other site 281309012617 AMP binding site [chemical binding]; other site 281309012618 active site 281309012619 CoA binding site [chemical binding]; other site 281309012620 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 281309012621 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 281309012622 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 281309012623 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 281309012624 Ligand Binding Site [chemical binding]; other site 281309012625 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 281309012626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309012627 catalytic residue [active] 281309012628 septation ring formation regulator EzrA; Provisional; Region: PRK04778 281309012629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309012630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309012631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 281309012632 dimerization interface [polypeptide binding]; other site 281309012633 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309012634 EamA-like transporter family; Region: EamA; pfam00892 281309012635 EamA-like transporter family; Region: EamA; pfam00892 281309012636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309012637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309012638 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 281309012639 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281309012640 homodimer interface [polypeptide binding]; other site 281309012641 substrate-cofactor binding pocket; other site 281309012642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309012643 catalytic residue [active] 281309012644 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 281309012645 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 281309012646 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309012647 RNA binding surface [nucleotide binding]; other site 281309012648 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 281309012649 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 281309012650 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 281309012651 active site 281309012652 HIGH motif; other site 281309012653 dimer interface [polypeptide binding]; other site 281309012654 KMSKS motif; other site 281309012655 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309012656 RNA binding surface [nucleotide binding]; other site 281309012657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309012658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 281309012659 acetyl-CoA synthetase; Provisional; Region: PRK04319 281309012660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281309012661 acyl-activating enzyme (AAE) consensus motif; other site 281309012662 AMP binding site [chemical binding]; other site 281309012663 active site 281309012664 CoA binding site [chemical binding]; other site 281309012665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309012666 Coenzyme A binding pocket [chemical binding]; other site 281309012667 FOG: CBS domain [General function prediction only]; Region: COG0517 281309012668 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 281309012669 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 281309012670 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 281309012671 active site 281309012672 Zn binding site [ion binding]; other site 281309012673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309012674 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309012675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309012676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309012677 active site 281309012678 phosphorylation site [posttranslational modification] 281309012679 intermolecular recognition site; other site 281309012680 dimerization interface [polypeptide binding]; other site 281309012681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309012682 DNA binding site [nucleotide binding] 281309012683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309012684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309012685 dimerization interface [polypeptide binding]; other site 281309012686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309012687 dimer interface [polypeptide binding]; other site 281309012688 phosphorylation site [posttranslational modification] 281309012689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309012690 ATP binding site [chemical binding]; other site 281309012691 Mg2+ binding site [ion binding]; other site 281309012692 G-X-G motif; other site 281309012693 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 281309012694 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309012695 Ankyrin repeat; Region: Ank; pfam00023 281309012696 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281309012697 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281309012698 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 281309012699 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281309012700 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281309012701 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 281309012702 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 281309012703 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 281309012704 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 281309012705 catabolite control protein A; Region: ccpA; TIGR01481 281309012706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309012707 DNA binding site [nucleotide binding] 281309012708 domain linker motif; other site 281309012709 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 281309012710 dimerization interface [polypeptide binding]; other site 281309012711 effector binding site; other site 281309012712 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 281309012713 putative dimer interface [polypeptide binding]; other site 281309012714 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 281309012715 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 281309012716 putative dimer interface [polypeptide binding]; other site 281309012717 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 281309012718 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 281309012719 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 281309012720 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 281309012721 Bacterial PH domain; Region: bPH_4; pfam06713 281309012722 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309012723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309012724 Coenzyme A binding pocket [chemical binding]; other site 281309012725 Predicted transcriptional regulators [Transcription]; Region: COG1695 281309012726 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 281309012727 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 281309012728 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281309012729 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281309012730 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281309012731 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 281309012732 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 281309012733 active site 281309012734 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 281309012735 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 281309012736 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 281309012737 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 281309012738 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 281309012739 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 281309012740 putative tRNA-binding site [nucleotide binding]; other site 281309012741 hypothetical protein; Provisional; Region: PRK13668 281309012742 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281309012743 catalytic residues [active] 281309012744 NTPase; Reviewed; Region: PRK03114 281309012745 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 281309012746 oligomer interface [polypeptide binding]; other site 281309012747 active site 281309012748 metal binding site [ion binding]; metal-binding site 281309012749 Predicted small secreted protein [Function unknown]; Region: COG5584 281309012750 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309012751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309012752 S-adenosylmethionine binding site [chemical binding]; other site 281309012753 YtzH-like protein; Region: YtzH; pfam14165 281309012754 Phosphotransferase enzyme family; Region: APH; pfam01636 281309012755 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 281309012756 active site 281309012757 substrate binding site [chemical binding]; other site 281309012758 ATP binding site [chemical binding]; other site 281309012759 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281309012760 pullulanase, type I; Region: pulA_typeI; TIGR02104 281309012761 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 281309012762 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 281309012763 Ca binding site [ion binding]; other site 281309012764 active site 281309012765 catalytic site [active] 281309012766 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 281309012767 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 281309012768 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 281309012769 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 281309012770 dipeptidase PepV; Reviewed; Region: PRK07318 281309012771 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 281309012772 active site 281309012773 metal binding site [ion binding]; metal-binding site 281309012774 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 281309012775 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 281309012776 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309012777 RNA binding surface [nucleotide binding]; other site 281309012778 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 281309012779 active site 281309012780 uracil binding [chemical binding]; other site 281309012781 stage V sporulation protein B; Region: spore_V_B; TIGR02900 281309012782 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 281309012783 HI0933-like protein; Region: HI0933_like; pfam03486 281309012784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309012785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309012786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309012787 putative substrate translocation pore; other site 281309012788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309012789 dimerization interface [polypeptide binding]; other site 281309012790 putative DNA binding site [nucleotide binding]; other site 281309012791 putative Zn2+ binding site [ion binding]; other site 281309012792 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 281309012793 putative hydrophobic ligand binding site [chemical binding]; other site 281309012794 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 281309012795 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 281309012796 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 281309012797 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 281309012798 glucose-1-dehydrogenase; Provisional; Region: PRK08936 281309012799 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 281309012800 NAD binding site [chemical binding]; other site 281309012801 homodimer interface [polypeptide binding]; other site 281309012802 active site 281309012803 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 281309012804 Sugar transport protein; Region: Sugar_transport; pfam06800 281309012805 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 281309012806 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 281309012807 MoaE interaction surface [polypeptide binding]; other site 281309012808 MoeB interaction surface [polypeptide binding]; other site 281309012809 thiocarboxylated glycine; other site 281309012810 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 281309012811 MoaE homodimer interface [polypeptide binding]; other site 281309012812 MoaD interaction [polypeptide binding]; other site 281309012813 active site residues [active] 281309012814 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 281309012815 Walker A motif; other site 281309012816 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 281309012817 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 281309012818 dimer interface [polypeptide binding]; other site 281309012819 putative functional site; other site 281309012820 putative MPT binding site; other site 281309012821 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 281309012822 trimer interface [polypeptide binding]; other site 281309012823 dimer interface [polypeptide binding]; other site 281309012824 putative active site [active] 281309012825 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 281309012826 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 281309012827 ATP binding site [chemical binding]; other site 281309012828 substrate interface [chemical binding]; other site 281309012829 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 281309012830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309012831 FeS/SAM binding site; other site 281309012832 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 281309012833 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 281309012834 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309012835 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309012836 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309012837 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309012838 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 281309012839 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 281309012840 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281309012841 active site residue [active] 281309012842 homoserine O-acetyltransferase; Provisional; Region: PRK06765 281309012843 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 281309012844 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 281309012845 Spore germination protein; Region: Spore_permease; pfam03845 281309012846 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 281309012847 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 281309012848 putative nucleotide binding site [chemical binding]; other site 281309012849 putative metal binding site [ion binding]; other site 281309012850 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 281309012851 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 281309012852 active site 281309012853 HIGH motif; other site 281309012854 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 281309012855 KMSKS motif; other site 281309012856 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 281309012857 tRNA binding surface [nucleotide binding]; other site 281309012858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309012859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309012860 putative substrate translocation pore; other site 281309012861 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 281309012862 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 281309012863 TrkA-C domain; Region: TrkA_C; pfam02080 281309012864 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 281309012865 Int/Topo IB signature motif; other site 281309012866 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309012867 FtsX-like permease family; Region: FtsX; pfam02687 281309012868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309012869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309012870 Walker A/P-loop; other site 281309012871 ATP binding site [chemical binding]; other site 281309012872 Q-loop/lid; other site 281309012873 ABC transporter signature motif; other site 281309012874 Walker B; other site 281309012875 D-loop; other site 281309012876 H-loop/switch region; other site 281309012877 Predicted membrane protein [Function unknown]; Region: COG2311 281309012878 Protein of unknown function (DUF418); Region: DUF418; pfam04235 281309012879 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 281309012880 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 281309012881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309012882 FeS/SAM binding site; other site 281309012883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309012884 S-adenosylmethionine binding site [chemical binding]; other site 281309012885 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309012886 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309012887 Walker A/P-loop; other site 281309012888 ATP binding site [chemical binding]; other site 281309012889 Q-loop/lid; other site 281309012890 ABC transporter signature motif; other site 281309012891 Walker B; other site 281309012892 D-loop; other site 281309012893 H-loop/switch region; other site 281309012894 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 281309012895 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 281309012896 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 281309012897 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 281309012898 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 281309012899 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 281309012900 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 281309012901 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 281309012902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309012903 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 281309012904 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 281309012905 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 281309012906 trimer interface [polypeptide binding]; other site 281309012907 putative metal binding site [ion binding]; other site 281309012908 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281309012909 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 281309012910 active site 281309012911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281309012912 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 281309012913 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 281309012914 GTP binding site; other site 281309012915 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 281309012916 MPT binding site; other site 281309012917 trimer interface [polypeptide binding]; other site 281309012918 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309012919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309012920 S-adenosylmethionine synthetase; Validated; Region: PRK05250 281309012921 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 281309012922 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 281309012923 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 281309012924 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 281309012925 active site 281309012926 substrate-binding site [chemical binding]; other site 281309012927 metal-binding site [ion binding] 281309012928 ATP binding site [chemical binding]; other site 281309012929 ATP synthase I chain; Region: ATP_synt_I; pfam03899 281309012930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309012931 EamA-like transporter family; Region: EamA; pfam00892 281309012932 EamA-like transporter family; Region: EamA; pfam00892 281309012933 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 281309012934 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 281309012935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309012936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309012937 ATP binding site [chemical binding]; other site 281309012938 Mg2+ binding site [ion binding]; other site 281309012939 G-X-G motif; other site 281309012940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309012941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309012942 dimer interface [polypeptide binding]; other site 281309012943 phosphorylation site [posttranslational modification] 281309012944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309012945 ATP binding site [chemical binding]; other site 281309012946 Mg2+ binding site [ion binding]; other site 281309012947 G-X-G motif; other site 281309012948 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281309012949 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309012950 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309012951 Secretory lipase; Region: LIP; pfam03583 281309012952 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 281309012953 Sulfatase; Region: Sulfatase; pfam00884 281309012954 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 281309012955 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 281309012956 NMT1-like family; Region: NMT1_2; pfam13379 281309012957 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 281309012958 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 281309012959 Walker A/P-loop; other site 281309012960 ATP binding site [chemical binding]; other site 281309012961 Q-loop/lid; other site 281309012962 ABC transporter signature motif; other site 281309012963 Walker B; other site 281309012964 D-loop; other site 281309012965 H-loop/switch region; other site 281309012966 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 281309012967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309012968 dimer interface [polypeptide binding]; other site 281309012969 conserved gate region; other site 281309012970 putative PBP binding loops; other site 281309012971 ABC-ATPase subunit interface; other site 281309012972 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 281309012973 active site 281309012974 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 281309012975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309012976 motif II; other site 281309012977 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 281309012978 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 281309012979 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 281309012980 nudix motif; other site 281309012981 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 281309012982 S-ribosylhomocysteinase; Provisional; Region: PRK02260 281309012983 hypothetical protein; Validated; Region: PRK00041 281309012984 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 281309012985 active site clefts [active] 281309012986 zinc binding site [ion binding]; other site 281309012987 dimer interface [polypeptide binding]; other site 281309012988 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 281309012989 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 281309012990 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 281309012991 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309012992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309012993 Transposase domain (DUF772); Region: DUF772; pfam05598 281309012994 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309012995 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 281309012996 S-layer homology domain; Region: SLH; pfam00395 281309012997 S-layer homology domain; Region: SLH; pfam00395 281309012998 S-layer homology domain; Region: SLH; pfam00395 281309012999 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 281309013000 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 281309013001 putative active site [active] 281309013002 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309013003 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309013004 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309013005 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 281309013006 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 281309013007 Predicted membrane protein [Function unknown]; Region: COG3766 281309013008 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 281309013009 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 281309013010 hypothetical protein; Provisional; Region: PRK12473 281309013011 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 281309013012 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 281309013013 G1 box; other site 281309013014 GTP/Mg2+ binding site [chemical binding]; other site 281309013015 Switch I region; other site 281309013016 G2 box; other site 281309013017 G3 box; other site 281309013018 Switch II region; other site 281309013019 G4 box; other site 281309013020 G5 box; other site 281309013021 Nucleoside recognition; Region: Gate; pfam07670 281309013022 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 281309013023 Nucleoside recognition; Region: Gate; pfam07670 281309013024 FeoA domain; Region: FeoA; pfam04023 281309013025 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 281309013026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 281309013027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309013028 dimerization interface [polypeptide binding]; other site 281309013029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309013030 dimer interface [polypeptide binding]; other site 281309013031 phosphorylation site [posttranslational modification] 281309013032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309013033 ATP binding site [chemical binding]; other site 281309013034 Mg2+ binding site [ion binding]; other site 281309013035 G-X-G motif; other site 281309013036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309013037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309013038 active site 281309013039 phosphorylation site [posttranslational modification] 281309013040 intermolecular recognition site; other site 281309013041 dimerization interface [polypeptide binding]; other site 281309013042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309013043 DNA binding site [nucleotide binding] 281309013044 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 281309013045 active site 281309013046 catalytic site [active] 281309013047 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 281309013048 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 281309013049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309013050 active site 281309013051 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 281309013052 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 281309013053 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 281309013054 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 281309013055 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 281309013056 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309013057 FtsX-like permease family; Region: FtsX; pfam02687 281309013058 FtsX-like permease family; Region: FtsX; pfam02687 281309013059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309013060 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309013061 Walker A/P-loop; other site 281309013062 ATP binding site [chemical binding]; other site 281309013063 Q-loop/lid; other site 281309013064 ABC transporter signature motif; other site 281309013065 Walker B; other site 281309013066 D-loop; other site 281309013067 H-loop/switch region; other site 281309013068 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 281309013069 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309013070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309013071 S-adenosylmethionine binding site [chemical binding]; other site 281309013072 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 281309013073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309013074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 281309013075 YolD-like protein; Region: YolD; pfam08863 281309013076 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309013077 FtsX-like permease family; Region: FtsX; pfam02687 281309013078 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309013079 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309013080 Walker A/P-loop; other site 281309013081 ATP binding site [chemical binding]; other site 281309013082 Q-loop/lid; other site 281309013083 ABC transporter signature motif; other site 281309013084 Walker B; other site 281309013085 D-loop; other site 281309013086 H-loop/switch region; other site 281309013087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 281309013088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 281309013089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309013090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309013091 active site 281309013092 phosphorylation site [posttranslational modification] 281309013093 intermolecular recognition site; other site 281309013094 dimerization interface [polypeptide binding]; other site 281309013095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309013096 DNA binding site [nucleotide binding] 281309013097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309013098 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 281309013099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309013100 ATP binding site [chemical binding]; other site 281309013101 Mg2+ binding site [ion binding]; other site 281309013102 G-X-G motif; other site 281309013103 FtsX-like permease family; Region: FtsX; pfam02687 281309013104 FtsX-like permease family; Region: FtsX; pfam02687 281309013105 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309013106 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309013107 Walker A/P-loop; other site 281309013108 ATP binding site [chemical binding]; other site 281309013109 Q-loop/lid; other site 281309013110 ABC transporter signature motif; other site 281309013111 Walker B; other site 281309013112 D-loop; other site 281309013113 H-loop/switch region; other site 281309013114 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309013115 FtsX-like permease family; Region: FtsX; pfam02687 281309013116 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281309013117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309013118 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 281309013119 Probable transposase; Region: OrfB_IS605; pfam01385 281309013120 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309013121 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 281309013122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281309013123 DNA-binding site [nucleotide binding]; DNA binding site 281309013124 UTRA domain; Region: UTRA; pfam07702 281309013125 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 281309013126 substrate binding site [chemical binding]; other site 281309013127 ATP binding site [chemical binding]; other site 281309013128 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 281309013129 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 281309013130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309013131 catalytic residue [active] 281309013132 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 281309013133 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 281309013134 active site 281309013135 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 281309013136 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 281309013137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309013138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309013139 dimerization interface [polypeptide binding]; other site 281309013140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309013141 dimer interface [polypeptide binding]; other site 281309013142 phosphorylation site [posttranslational modification] 281309013143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309013144 ATP binding site [chemical binding]; other site 281309013145 Mg2+ binding site [ion binding]; other site 281309013146 G-X-G motif; other site 281309013147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309013148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309013149 active site 281309013150 phosphorylation site [posttranslational modification] 281309013151 intermolecular recognition site; other site 281309013152 dimerization interface [polypeptide binding]; other site 281309013153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309013154 DNA binding site [nucleotide binding] 281309013155 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 281309013156 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 281309013157 active site 281309013158 octamer interface [polypeptide binding]; other site 281309013159 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 281309013160 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 281309013161 acyl-activating enzyme (AAE) consensus motif; other site 281309013162 putative AMP binding site [chemical binding]; other site 281309013163 putative active site [active] 281309013164 putative CoA binding site [chemical binding]; other site 281309013165 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 281309013166 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309013167 substrate binding site [chemical binding]; other site 281309013168 oxyanion hole (OAH) forming residues; other site 281309013169 trimer interface [polypeptide binding]; other site 281309013170 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 281309013171 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309013172 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 281309013173 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 281309013174 dimer interface [polypeptide binding]; other site 281309013175 tetramer interface [polypeptide binding]; other site 281309013176 PYR/PP interface [polypeptide binding]; other site 281309013177 TPP binding site [chemical binding]; other site 281309013178 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281309013179 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 281309013180 TPP-binding site; other site 281309013181 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 281309013182 chorismate binding enzyme; Region: Chorismate_bind; cl10555 281309013183 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 281309013184 putative active site [active] 281309013185 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 281309013186 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281309013187 DNA-binding site [nucleotide binding]; DNA binding site 281309013188 RNA-binding motif; other site 281309013189 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 281309013190 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 281309013191 active site flap/lid [active] 281309013192 nucleophilic elbow; other site 281309013193 catalytic triad [active] 281309013194 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 281309013195 homodimer interface [polypeptide binding]; other site 281309013196 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 281309013197 active site pocket [active] 281309013198 glycogen synthase; Provisional; Region: glgA; PRK00654 281309013199 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 281309013200 ADP-binding pocket [chemical binding]; other site 281309013201 homodimer interface [polypeptide binding]; other site 281309013202 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 281309013203 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 281309013204 ligand binding site; other site 281309013205 oligomer interface; other site 281309013206 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 281309013207 dimer interface [polypeptide binding]; other site 281309013208 N-terminal domain interface [polypeptide binding]; other site 281309013209 sulfate 1 binding site; other site 281309013210 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 281309013211 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 281309013212 ligand binding site; other site 281309013213 oligomer interface; other site 281309013214 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 281309013215 dimer interface [polypeptide binding]; other site 281309013216 N-terminal domain interface [polypeptide binding]; other site 281309013217 sulfate 1 binding site; other site 281309013218 glycogen branching enzyme; Provisional; Region: PRK12313 281309013219 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 281309013220 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 281309013221 active site 281309013222 catalytic site [active] 281309013223 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 281309013224 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 281309013225 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 281309013226 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309013227 NAD binding site [chemical binding]; other site 281309013228 dimer interface [polypeptide binding]; other site 281309013229 substrate binding site [chemical binding]; other site 281309013230 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 281309013231 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 281309013232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309013233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309013234 DNA binding residues [nucleotide binding] 281309013235 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 281309013236 MgtC family; Region: MgtC; pfam02308 281309013237 Ion channel; Region: Ion_trans_2; pfam07885 281309013238 TrkA-N domain; Region: TrkA_N; pfam02254 281309013239 YugN-like family; Region: YugN; pfam08868 281309013240 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 281309013241 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 281309013242 active site 281309013243 dimer interface [polypeptide binding]; other site 281309013244 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 281309013245 dimer interface [polypeptide binding]; other site 281309013246 active site 281309013247 Domain of unknown function (DUF378); Region: DUF378; pfam04070 281309013248 general stress protein 13; Validated; Region: PRK08059 281309013249 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 281309013250 RNA binding site [nucleotide binding]; other site 281309013251 aspartate aminotransferase; Provisional; Region: PRK05764 281309013252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309013253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309013254 homodimer interface [polypeptide binding]; other site 281309013255 catalytic residue [active] 281309013256 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 281309013257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281309013258 AsnC family; Region: AsnC_trans_reg; pfam01037 281309013259 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 281309013260 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 281309013261 dimerization interface [polypeptide binding]; other site 281309013262 ligand binding site [chemical binding]; other site 281309013263 NADP binding site [chemical binding]; other site 281309013264 catalytic site [active] 281309013265 Putative lysophospholipase; Region: Hydrolase_4; cl19140 281309013266 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281309013267 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 281309013268 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 281309013269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281309013270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309013271 homodimer interface [polypeptide binding]; other site 281309013272 catalytic residue [active] 281309013273 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 281309013274 E-class dimer interface [polypeptide binding]; other site 281309013275 P-class dimer interface [polypeptide binding]; other site 281309013276 active site 281309013277 Cu2+ binding site [ion binding]; other site 281309013278 Zn2+ binding site [ion binding]; other site 281309013279 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 281309013280 Kinase associated protein B; Region: KapB; pfam08810 281309013281 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 281309013282 active site 281309013283 catalytic site [active] 281309013284 substrate binding site [chemical binding]; other site 281309013285 Citrate transporter; Region: CitMHS; pfam03600 281309013286 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 281309013287 transmembrane helices; other site 281309013288 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 281309013289 active site 281309013290 glycyl-tRNA synthetase; Provisional; Region: PRK04173 281309013291 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 281309013292 dimer interface [polypeptide binding]; other site 281309013293 motif 1; other site 281309013294 active site 281309013295 motif 2; other site 281309013296 motif 3; other site 281309013297 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 281309013298 anticodon binding site; other site 281309013299 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 281309013300 CoenzymeA binding site [chemical binding]; other site 281309013301 subunit interaction site [polypeptide binding]; other site 281309013302 PHB binding site; other site 281309013303 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 281309013304 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 281309013305 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 281309013306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309013307 Transposase domain (DUF772); Region: DUF772; pfam05598 281309013308 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309013309 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309013310 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 281309013311 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 281309013312 active site 281309013313 tetramer interface; other site 281309013314 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 281309013315 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 281309013316 active site 281309013317 substrate binding site [chemical binding]; other site 281309013318 metal binding site [ion binding]; metal-binding site 281309013319 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 281309013320 Uncharacterized conserved protein [Function unknown]; Region: COG1624 281309013321 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 281309013322 multifunctional aminopeptidase A; Provisional; Region: PRK00913 281309013323 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 281309013324 interface (dimer of trimers) [polypeptide binding]; other site 281309013325 Substrate-binding/catalytic site; other site 281309013326 Zn-binding sites [ion binding]; other site 281309013327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 281309013328 Putative membrane protein; Region: YuiB; pfam14068 281309013329 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 281309013330 nudix motif; other site 281309013331 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 281309013332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309013333 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 281309013334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309013335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309013336 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013337 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013338 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013339 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013340 Domain of unknown function DUF11; Region: DUF11; cl17728 281309013341 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013342 Domain of unknown function DUF11; Region: DUF11; pfam01345 281309013343 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013344 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013345 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013346 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013347 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013348 Alginate lyase; Region: Alginate_lyase2; pfam08787 281309013349 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013350 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013351 Domain of unknown function DUF11; Region: DUF11; pfam01345 281309013352 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013353 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013354 Domain of unknown function DUF11; Region: DUF11; pfam01345 281309013355 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013356 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 281309013357 WTX protein; Region: WTX; pfam09422 281309013358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 281309013359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309013360 H+ Antiporter protein; Region: 2A0121; TIGR00900 281309013361 putative substrate translocation pore; other site 281309013362 Helix-turn-helix domain; Region: HTH_36; pfam13730 281309013363 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 281309013364 Protein of unknown function (DUF523); Region: DUF523; pfam04463 281309013365 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 281309013366 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 281309013367 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 281309013368 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 281309013369 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 281309013370 hypothetical protein; Provisional; Region: PRK13669 281309013371 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 281309013372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309013373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309013374 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 281309013375 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309013376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309013377 Walker A/P-loop; other site 281309013378 ATP binding site [chemical binding]; other site 281309013379 Q-loop/lid; other site 281309013380 ABC transporter signature motif; other site 281309013381 Walker B; other site 281309013382 D-loop; other site 281309013383 H-loop/switch region; other site 281309013384 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 281309013385 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 281309013386 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 281309013387 PhnA protein; Region: PhnA; pfam03831 281309013388 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 281309013389 CAAX protease self-immunity; Region: Abi; pfam02517 281309013390 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 281309013391 active site 281309013392 NTP binding site [chemical binding]; other site 281309013393 metal binding triad [ion binding]; metal-binding site 281309013394 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 281309013395 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 281309013396 NifU-like domain; Region: NifU; pfam01106 281309013397 spore coat protein YutH; Region: spore_yutH; TIGR02905 281309013398 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 281309013399 tetramer interfaces [polypeptide binding]; other site 281309013400 binuclear metal-binding site [ion binding]; other site 281309013401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 281309013402 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309013403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309013404 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309013405 FtsX-like permease family; Region: FtsX; pfam02687 281309013406 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309013407 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309013408 FtsX-like permease family; Region: FtsX; pfam02687 281309013409 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309013410 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309013411 Walker A/P-loop; other site 281309013412 ATP binding site [chemical binding]; other site 281309013413 Q-loop/lid; other site 281309013414 ABC transporter signature motif; other site 281309013415 Walker B; other site 281309013416 D-loop; other site 281309013417 H-loop/switch region; other site 281309013418 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 281309013419 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 281309013420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309013421 active site 281309013422 motif I; other site 281309013423 motif II; other site 281309013424 Predicted transcriptional regulator [Transcription]; Region: COG2345 281309013425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309013426 putative Zn2+ binding site [ion binding]; other site 281309013427 putative DNA binding site [nucleotide binding]; other site 281309013428 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 281309013429 Uncharacterized conserved protein [Function unknown]; Region: COG2445 281309013430 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 281309013431 putative active site [active] 281309013432 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 281309013433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 281309013434 Probable transposase; Region: OrfB_IS605; pfam01385 281309013435 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309013436 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 281309013437 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 281309013438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309013439 RNA binding surface [nucleotide binding]; other site 281309013440 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 281309013441 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 281309013442 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309013443 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 281309013444 DNA binding residues [nucleotide binding] 281309013445 dimer interface [polypeptide binding]; other site 281309013446 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 281309013447 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 281309013448 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281309013449 catalytic core [active] 281309013450 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 281309013451 putative deacylase active site [active] 281309013452 lipoyl synthase; Provisional; Region: PRK05481 281309013453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309013454 FeS/SAM binding site; other site 281309013455 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309013456 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309013457 sporulation protein YunB; Region: spo_yunB; TIGR02832 281309013458 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 281309013459 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 281309013460 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 281309013461 active site 281309013462 metal binding site [ion binding]; metal-binding site 281309013463 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 281309013464 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 281309013465 FeS assembly protein SufB; Region: sufB; TIGR01980 281309013466 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 281309013467 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 281309013468 trimerization site [polypeptide binding]; other site 281309013469 active site 281309013470 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 281309013471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281309013472 catalytic residue [active] 281309013473 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 281309013474 FeS assembly protein SufD; Region: sufD; TIGR01981 281309013475 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 281309013476 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 281309013477 Walker A/P-loop; other site 281309013478 ATP binding site [chemical binding]; other site 281309013479 Q-loop/lid; other site 281309013480 ABC transporter signature motif; other site 281309013481 Walker B; other site 281309013482 D-loop; other site 281309013483 H-loop/switch region; other site 281309013484 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 281309013485 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 281309013486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281309013487 dimer interface [polypeptide binding]; other site 281309013488 conserved gate region; other site 281309013489 putative PBP binding loops; other site 281309013490 ABC-ATPase subunit interface; other site 281309013491 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 281309013492 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 281309013493 Walker A/P-loop; other site 281309013494 ATP binding site [chemical binding]; other site 281309013495 Q-loop/lid; other site 281309013496 ABC transporter signature motif; other site 281309013497 Walker B; other site 281309013498 D-loop; other site 281309013499 H-loop/switch region; other site 281309013500 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 281309013501 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281309013502 catalytic residues [active] 281309013503 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 281309013504 active site 281309013505 metal binding site [ion binding]; metal-binding site 281309013506 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 281309013507 lipoyl attachment site [posttranslational modification]; other site 281309013508 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 281309013509 putative ArsC-like catalytic residues; other site 281309013510 putative TRX-like catalytic residues [active] 281309013511 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 281309013512 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 281309013513 active site 281309013514 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 281309013515 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 281309013516 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 281309013517 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309013518 NAD binding site [chemical binding]; other site 281309013519 dimer interface [polypeptide binding]; other site 281309013520 substrate binding site [chemical binding]; other site 281309013521 Coat F domain; Region: Coat_F; pfam07875 281309013522 CAAX protease self-immunity; Region: Abi; pfam02517 281309013523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309013524 salt bridge; other site 281309013525 non-specific DNA binding site [nucleotide binding]; other site 281309013526 sequence-specific DNA binding site [nucleotide binding]; other site 281309013527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309013528 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 281309013529 WHG domain; Region: WHG; pfam13305 281309013530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281309013531 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 281309013532 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281309013533 active site 281309013534 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 281309013535 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 281309013536 dimer interface [polypeptide binding]; other site 281309013537 active site 281309013538 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 281309013539 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 281309013540 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 281309013541 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 281309013542 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281309013543 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 281309013544 substrate binding site [chemical binding]; other site 281309013545 oxyanion hole (OAH) forming residues; other site 281309013546 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309013547 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309013548 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 281309013549 Proline dehydrogenase; Region: Pro_dh; pfam01619 281309013550 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 281309013551 Domain of unknown function DUF77; Region: DUF77; pfam01910 281309013552 Cache domain; Region: Cache_1; pfam02743 281309013553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309013554 dimerization interface [polypeptide binding]; other site 281309013555 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 281309013556 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309013557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309013558 dimer interface [polypeptide binding]; other site 281309013559 putative CheW interface [polypeptide binding]; other site 281309013560 Predicted transcriptional regulators [Transcription]; Region: COG1378 281309013561 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 281309013562 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 281309013563 C-terminal domain interface [polypeptide binding]; other site 281309013564 sugar binding site [chemical binding]; other site 281309013565 TQXA domain; Region: TQXA_dom; TIGR03934 281309013566 Cna protein B-type domain; Region: Cna_B; pfam05738 281309013567 Cna protein B-type domain; Region: Cna_B; pfam05738 281309013568 Cna protein B-type domain; Region: Cna_B; pfam05738 281309013569 Cna protein B-type domain; Region: Cna_B; pfam05738 281309013570 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 281309013571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309013572 putative substrate translocation pore; other site 281309013573 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 281309013574 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 281309013575 MAEBL; Provisional; Region: PTZ00121 281309013576 OxaA-like protein precursor; Validated; Region: PRK01622 281309013577 Uncharacterized conserved protein [Function unknown]; Region: COG1284 281309013578 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309013579 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309013580 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 281309013581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309013582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281309013583 hypothetical protein; Provisional; Region: PRK06758 281309013584 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 281309013585 active site 281309013586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309013587 non-specific DNA binding site [nucleotide binding]; other site 281309013588 salt bridge; other site 281309013589 sequence-specific DNA binding site [nucleotide binding]; other site 281309013590 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309013591 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 281309013592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 281309013593 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 281309013594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309013595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309013596 active site 281309013597 phosphorylation site [posttranslational modification] 281309013598 intermolecular recognition site; other site 281309013599 dimerization interface [polypeptide binding]; other site 281309013600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309013601 DNA binding site [nucleotide binding] 281309013602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309013603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309013604 dimer interface [polypeptide binding]; other site 281309013605 phosphorylation site [posttranslational modification] 281309013606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309013607 ATP binding site [chemical binding]; other site 281309013608 Mg2+ binding site [ion binding]; other site 281309013609 G-X-G motif; other site 281309013610 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281309013611 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 281309013612 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 281309013613 active site 281309013614 HIGH motif; other site 281309013615 KMSKS motif; other site 281309013616 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 281309013617 tRNA binding surface [nucleotide binding]; other site 281309013618 anticodon binding site; other site 281309013619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309013620 S-adenosylmethionine binding site [chemical binding]; other site 281309013621 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 281309013622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309013623 dimerization interface [polypeptide binding]; other site 281309013624 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309013625 dimer interface [polypeptide binding]; other site 281309013626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309013627 dimer interface [polypeptide binding]; other site 281309013628 putative CheW interface [polypeptide binding]; other site 281309013629 CHASE3 domain; Region: CHASE3; cl05000 281309013630 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 281309013631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309013632 dimerization interface [polypeptide binding]; other site 281309013633 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309013634 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 281309013635 dimer interface [polypeptide binding]; other site 281309013636 putative CheW interface [polypeptide binding]; other site 281309013637 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 281309013638 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 281309013639 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 281309013640 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 281309013641 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 281309013642 active site 281309013643 Zn binding site [ion binding]; other site 281309013644 Pirin-related protein [General function prediction only]; Region: COG1741 281309013645 Pirin; Region: Pirin; pfam02678 281309013646 Transcriptional regulators [Transcription]; Region: MarR; COG1846 281309013647 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281309013648 putative Zn2+ binding site [ion binding]; other site 281309013649 putative DNA binding site [nucleotide binding]; other site 281309013650 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 281309013651 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 281309013652 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 281309013653 TrkA-C domain; Region: TrkA_C; pfam02080 281309013654 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 281309013655 Ferritin-like domain; Region: Ferritin; pfam00210 281309013656 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 281309013657 dimerization interface [polypeptide binding]; other site 281309013658 DPS ferroxidase diiron center [ion binding]; other site 281309013659 ion pore; other site 281309013660 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 281309013661 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 281309013662 metal binding site [ion binding]; metal-binding site 281309013663 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 281309013664 Ferritin-like domain; Region: Ferritin; pfam00210 281309013665 ferroxidase diiron center [ion binding]; other site 281309013666 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309013667 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309013668 Nucleoside recognition; Region: Gate; pfam07670 281309013669 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309013670 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309013671 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309013672 Nucleoside recognition; Region: Gate; pfam07670 281309013673 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309013674 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 281309013675 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 281309013676 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 281309013677 NAD binding site [chemical binding]; other site 281309013678 substrate binding site [chemical binding]; other site 281309013679 putative active site [active] 281309013680 Peptidase M60-like family; Region: M60-like; pfam13402 281309013681 Peptidase M60-like family; Region: M60-like; cl19940 281309013682 TQXA domain; Region: TQXA_dom; TIGR03934 281309013683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281309013684 active site 281309013685 catalytic tetrad [active] 281309013686 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 281309013687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309013688 putative substrate translocation pore; other site 281309013689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309013690 dimerization interface [polypeptide binding]; other site 281309013691 putative DNA binding site [nucleotide binding]; other site 281309013692 putative Zn2+ binding site [ion binding]; other site 281309013693 Uncharacterized conserved protein [Function unknown]; Region: COG2427 281309013694 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 281309013695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309013696 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 281309013697 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 281309013698 active site 281309013699 HIGH motif; other site 281309013700 dimer interface [polypeptide binding]; other site 281309013701 KMSKS motif; other site 281309013702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281309013703 RNA binding surface [nucleotide binding]; other site 281309013704 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 281309013705 FAD binding domain; Region: FAD_binding_4; pfam01565 281309013706 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 281309013707 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309013708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309013709 Transposase domain (DUF772); Region: DUF772; pfam05598 281309013710 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309013711 SET domain; Region: SET; pfam00856 281309013712 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 281309013713 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 281309013714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309013715 dimer interface [polypeptide binding]; other site 281309013716 putative CheW interface [polypeptide binding]; other site 281309013717 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 281309013718 putative catalytic site [active] 281309013719 putative metal binding site [ion binding]; other site 281309013720 putative phosphate binding site [ion binding]; other site 281309013721 camphor resistance protein CrcB; Provisional; Region: PRK14219 281309013722 camphor resistance protein CrcB; Provisional; Region: PRK14205 281309013723 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 281309013724 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 281309013725 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281309013726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309013727 Coenzyme A binding pocket [chemical binding]; other site 281309013728 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 281309013729 Nuclease-related domain; Region: NERD; pfam08378 281309013730 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 281309013731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281309013732 Walker A/P-loop; other site 281309013733 ATP binding site [chemical binding]; other site 281309013734 Q-loop/lid; other site 281309013735 ABC transporter signature motif; other site 281309013736 Walker B; other site 281309013737 D-loop; other site 281309013738 H-loop/switch region; other site 281309013739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309013740 ABC-ATPase subunit interface; other site 281309013741 dimer interface [polypeptide binding]; other site 281309013742 putative PBP binding regions; other site 281309013743 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309013744 ABC-ATPase subunit interface; other site 281309013745 dimer interface [polypeptide binding]; other site 281309013746 putative PBP binding regions; other site 281309013747 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 281309013748 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 281309013749 putative ligand binding residues [chemical binding]; other site 281309013750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309013751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309013752 active site 281309013753 phosphorylation site [posttranslational modification] 281309013754 intermolecular recognition site; other site 281309013755 dimerization interface [polypeptide binding]; other site 281309013756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309013757 DNA binding site [nucleotide binding] 281309013758 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309013759 FtsX-like permease family; Region: FtsX; pfam02687 281309013760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309013761 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309013762 Walker A/P-loop; other site 281309013763 ATP binding site [chemical binding]; other site 281309013764 Q-loop/lid; other site 281309013765 ABC transporter signature motif; other site 281309013766 Walker B; other site 281309013767 D-loop; other site 281309013768 H-loop/switch region; other site 281309013769 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 281309013770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281309013771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309013772 dimerization interface [polypeptide binding]; other site 281309013773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309013774 dimer interface [polypeptide binding]; other site 281309013775 phosphorylation site [posttranslational modification] 281309013776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309013777 ATP binding site [chemical binding]; other site 281309013778 Mg2+ binding site [ion binding]; other site 281309013779 G-X-G motif; other site 281309013780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309013781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309013782 active site 281309013783 phosphorylation site [posttranslational modification] 281309013784 intermolecular recognition site; other site 281309013785 dimerization interface [polypeptide binding]; other site 281309013786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309013787 DNA binding site [nucleotide binding] 281309013788 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281309013789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309013790 S-adenosylmethionine binding site [chemical binding]; other site 281309013791 Predicted membrane protein [Function unknown]; Region: COG2311 281309013792 Protein of unknown function (DUF418); Region: DUF418; pfam04235 281309013793 CAAX protease self-immunity; Region: Abi; pfam02517 281309013794 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 281309013795 SmpB-tmRNA interface; other site 281309013796 ribonuclease R; Region: RNase_R; TIGR02063 281309013797 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 281309013798 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 281309013799 RNB domain; Region: RNB; pfam00773 281309013800 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 281309013801 RNA binding site [nucleotide binding]; other site 281309013802 Esterase/lipase [General function prediction only]; Region: COG1647 281309013803 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 281309013804 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 281309013805 holin-like protein; Validated; Region: PRK01658 281309013806 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 281309013807 active site 281309013808 enolase; Provisional; Region: eno; PRK00077 281309013809 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 281309013810 dimer interface [polypeptide binding]; other site 281309013811 metal binding site [ion binding]; metal-binding site 281309013812 substrate binding pocket [chemical binding]; other site 281309013813 phosphoglyceromutase; Provisional; Region: PRK05434 281309013814 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 281309013815 substrate binding site [chemical binding]; other site 281309013816 dimer interface [polypeptide binding]; other site 281309013817 catalytic triad [active] 281309013818 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 281309013819 substrate binding site [chemical binding]; other site 281309013820 hinge regions; other site 281309013821 ADP binding site [chemical binding]; other site 281309013822 catalytic site [active] 281309013823 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 281309013824 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 281309013825 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 281309013826 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 281309013827 Predicted transcriptional regulator [Transcription]; Region: COG3388 281309013828 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 281309013829 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 281309013830 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 281309013831 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 281309013832 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 281309013833 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 281309013834 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 281309013835 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 281309013836 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 281309013837 stage V sporulation protein AD; Provisional; Region: PRK12404 281309013838 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 281309013839 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 281309013840 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 281309013841 Predicted membrane protein [Function unknown]; Region: COG2323 281309013842 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 281309013843 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 281309013844 oligomer interface [polypeptide binding]; other site 281309013845 active site residues [active] 281309013846 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 281309013847 dimerization domain swap beta strand [polypeptide binding]; other site 281309013848 regulatory protein interface [polypeptide binding]; other site 281309013849 active site 281309013850 regulatory phosphorylation site [posttranslational modification]; other site 281309013851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 281309013852 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 281309013853 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 281309013854 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 281309013855 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 281309013856 phosphate binding site [ion binding]; other site 281309013857 putative substrate binding pocket [chemical binding]; other site 281309013858 dimer interface [polypeptide binding]; other site 281309013859 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 281309013860 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 281309013861 putative active site [active] 281309013862 nucleotide binding site [chemical binding]; other site 281309013863 nudix motif; other site 281309013864 putative metal binding site [ion binding]; other site 281309013865 Domain of unknown function (DUF368); Region: DUF368; pfam04018 281309013866 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 281309013867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 281309013868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281309013869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309013870 binding surface 281309013871 TPR motif; other site 281309013872 Tetratricopeptide repeat; Region: TPR_12; pfam13424 281309013873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 281309013874 binding surface 281309013875 Tetratricopeptide repeat; Region: TPR_16; pfam13432 281309013876 TPR motif; other site 281309013877 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 281309013878 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 281309013879 trimer interface [polypeptide binding]; other site 281309013880 active site 281309013881 substrate binding site [chemical binding]; other site 281309013882 CoA binding site [chemical binding]; other site 281309013883 pyrophosphatase PpaX; Provisional; Region: PRK13288 281309013884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309013885 active site 281309013886 motif I; other site 281309013887 motif II; other site 281309013888 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 281309013889 HPr kinase/phosphorylase; Provisional; Region: PRK05428 281309013890 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 281309013891 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 281309013892 Hpr binding site; other site 281309013893 active site 281309013894 homohexamer subunit interaction site [polypeptide binding]; other site 281309013895 Predicted membrane protein [Function unknown]; Region: COG1950 281309013896 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 281309013897 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 281309013898 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 281309013899 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 281309013900 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 281309013901 excinuclease ABC subunit B; Provisional; Region: PRK05298 281309013902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309013903 ATP binding site [chemical binding]; other site 281309013904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309013905 nucleotide binding region [chemical binding]; other site 281309013906 ATP-binding site [chemical binding]; other site 281309013907 Ultra-violet resistance protein B; Region: UvrB; pfam12344 281309013908 UvrB/uvrC motif; Region: UVR; pfam02151 281309013909 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 281309013910 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 281309013911 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309013912 DNA binding residues [nucleotide binding] 281309013913 dimer interface [polypeptide binding]; other site 281309013914 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 281309013915 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309013916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309013917 non-specific DNA binding site [nucleotide binding]; other site 281309013918 salt bridge; other site 281309013919 sequence-specific DNA binding site [nucleotide binding]; other site 281309013920 Predicted membrane protein [Function unknown]; Region: COG2855 281309013921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309013922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309013923 Retrotransposon hot spot protein; Region: RHSP; cl19421 281309013924 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 281309013925 putative dimerization interface [polypeptide binding]; other site 281309013926 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309013927 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 281309013928 DNA binding residues [nucleotide binding] 281309013929 putative dimer interface [polypeptide binding]; other site 281309013930 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 281309013931 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309013932 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309013933 ABC transporter; Region: ABC_tran_2; pfam12848 281309013934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309013935 hypothetical protein; Provisional; Region: PRK12855 281309013936 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281309013937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281309013938 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 281309013939 Walker A/P-loop; other site 281309013940 ATP binding site [chemical binding]; other site 281309013941 Q-loop/lid; other site 281309013942 ABC transporter signature motif; other site 281309013943 Walker B; other site 281309013944 D-loop; other site 281309013945 H-loop/switch region; other site 281309013946 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 281309013947 protein binding site [polypeptide binding]; other site 281309013948 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 281309013949 C-terminal peptidase (prc); Region: prc; TIGR00225 281309013950 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 281309013951 protein binding site [polypeptide binding]; other site 281309013952 Catalytic dyad [active] 281309013953 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 281309013954 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 281309013955 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 281309013956 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 281309013957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309013958 Walker A/P-loop; other site 281309013959 ATP binding site [chemical binding]; other site 281309013960 Q-loop/lid; other site 281309013961 ABC transporter signature motif; other site 281309013962 Walker B; other site 281309013963 D-loop; other site 281309013964 H-loop/switch region; other site 281309013965 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 281309013966 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 281309013967 peptide chain release factor 2; Provisional; Region: PRK06746 281309013968 This domain is found in peptide chain release factors; Region: PCRF; smart00937 281309013969 RF-1 domain; Region: RF-1; pfam00472 281309013970 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 281309013971 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 281309013972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309013973 nucleotide binding region [chemical binding]; other site 281309013974 ATP-binding site [chemical binding]; other site 281309013975 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 281309013976 SEC-C motif; Region: SEC-C; cl19389 281309013977 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 281309013978 30S subunit binding site; other site 281309013979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281309013980 DNA-binding site [nucleotide binding]; DNA binding site 281309013981 RNA-binding motif; other site 281309013982 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 281309013983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309013984 active site 281309013985 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 281309013986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309013987 ATP binding site [chemical binding]; other site 281309013988 putative Mg++ binding site [ion binding]; other site 281309013989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309013990 nucleotide binding region [chemical binding]; other site 281309013991 ATP-binding site [chemical binding]; other site 281309013992 Sperm tail; Region: NYD-SP28; pfam14772 281309013993 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 281309013994 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 281309013995 NlpC/P60 family; Region: NLPC_P60; pfam00877 281309013996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309013997 dimerization interface [polypeptide binding]; other site 281309013998 putative DNA binding site [nucleotide binding]; other site 281309013999 putative Zn2+ binding site [ion binding]; other site 281309014000 EDD domain protein, DegV family; Region: DegV; TIGR00762 281309014001 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 281309014002 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 281309014003 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 281309014004 Transcriptional regulator [Transcription]; Region: LytR; COG1316 281309014005 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 281309014006 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 281309014007 active site 281309014008 homodimer interface [polypeptide binding]; other site 281309014009 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 281309014010 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 281309014011 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 281309014012 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 281309014013 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 281309014014 Mg++ binding site [ion binding]; other site 281309014015 putative catalytic motif [active] 281309014016 substrate binding site [chemical binding]; other site 281309014017 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 281309014018 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 281309014019 NodB motif; other site 281309014020 active site 281309014021 catalytic site [active] 281309014022 Zn binding site [ion binding]; other site 281309014023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281309014024 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 281309014025 Walker A motif; other site 281309014026 ATP binding site [chemical binding]; other site 281309014027 Walker B motif; other site 281309014028 arginine finger; other site 281309014029 Transcriptional antiterminator [Transcription]; Region: COG3933 281309014030 PRD domain; Region: PRD; pfam00874 281309014031 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 281309014032 active pocket/dimerization site; other site 281309014033 active site 281309014034 phosphorylation site [posttranslational modification] 281309014035 PRD domain; Region: PRD; pfam00874 281309014036 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 281309014037 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 281309014038 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 281309014039 Chromate transporter; Region: Chromate_transp; pfam02417 281309014040 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 281309014041 putative active site [active] 281309014042 YdjC motif; other site 281309014043 Mg binding site [ion binding]; other site 281309014044 putative homodimer interface [polypeptide binding]; other site 281309014045 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 281309014046 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 281309014047 NAD binding site [chemical binding]; other site 281309014048 sugar binding site [chemical binding]; other site 281309014049 divalent metal binding site [ion binding]; other site 281309014050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309014051 dimer interface [polypeptide binding]; other site 281309014052 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 281309014053 active site 281309014054 methionine cluster; other site 281309014055 phosphorylation site [posttranslational modification] 281309014056 metal binding site [ion binding]; metal-binding site 281309014057 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 281309014058 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 281309014059 active site 281309014060 P-loop; other site 281309014061 phosphorylation site [posttranslational modification] 281309014062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309014063 S-adenosylmethionine binding site [chemical binding]; other site 281309014064 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 281309014065 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 281309014066 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 281309014067 LytTr DNA-binding domain; Region: LytTR; smart00850 281309014068 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 281309014069 methionine cluster; other site 281309014070 active site 281309014071 phosphorylation site [posttranslational modification] 281309014072 metal binding site [ion binding]; metal-binding site 281309014073 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 281309014074 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 281309014075 active site 281309014076 P-loop; other site 281309014077 phosphorylation site [posttranslational modification] 281309014078 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 281309014079 Acyltransferase family; Region: Acyl_transf_3; pfam01757 281309014080 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 281309014081 Predicted membrane protein [Function unknown]; Region: COG1511 281309014082 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 281309014083 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 281309014084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281309014085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281309014086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 281309014087 dimerization interface [polypeptide binding]; other site 281309014088 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 281309014089 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 281309014090 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 281309014091 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 281309014092 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 281309014093 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 281309014094 transmembrane helices; other site 281309014095 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 281309014096 ThiC-associated domain; Region: ThiC-associated; pfam13667 281309014097 ThiC family; Region: ThiC; pfam01964 281309014098 L-lactate permease; Region: Lactate_perm; cl00701 281309014099 Tic20-like protein; Region: Tic20; pfam09685 281309014100 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 281309014101 Uncharacterized conserved protein [Function unknown]; Region: COG3339 281309014102 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 281309014103 Sulfatase; Region: Sulfatase; pfam00884 281309014104 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 281309014105 homodimer interface [polypeptide binding]; other site 281309014106 substrate-cofactor binding pocket; other site 281309014107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309014108 catalytic residue [active] 281309014109 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309014110 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 281309014111 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309014112 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 281309014113 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309014114 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309014115 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 281309014116 NlpC/P60 family; Region: NLPC_P60; pfam00877 281309014117 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 281309014118 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 281309014119 Nucleoside recognition; Region: Gate; pfam07670 281309014120 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 281309014121 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 281309014122 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 281309014123 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 281309014124 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 281309014125 DXD motif; other site 281309014126 BCCT family transporter; Region: BCCT; pfam02028 281309014127 Bacterial SH3 domain; Region: SH3_3; pfam08239 281309014128 Bacterial SH3 domain homologues; Region: SH3b; smart00287 281309014129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 281309014130 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 281309014131 Predicted membrane protein [Function unknown]; Region: COG4640 281309014132 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 281309014133 Double zinc ribbon; Region: DZR; pfam12773 281309014134 Double zinc ribbon; Region: DZR; pfam12773 281309014135 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 281309014136 Uncharacterized conserved protein [Function unknown]; Region: COG4715 281309014137 SNF2 Helicase protein; Region: DUF3670; pfam12419 281309014138 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 281309014139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281309014140 ATP binding site [chemical binding]; other site 281309014141 putative Mg++ binding site [ion binding]; other site 281309014142 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 281309014143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309014144 nucleotide binding region [chemical binding]; other site 281309014145 ATP-binding site [chemical binding]; other site 281309014146 Predicted integral membrane protein [Function unknown]; Region: COG5652 281309014147 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 281309014148 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 281309014149 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 281309014150 ComK protein; Region: ComK; cl11560 281309014151 RNA polymerase factor sigma-70; Validated; Region: PRK06759 281309014152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309014153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 281309014154 DNA binding residues [nucleotide binding] 281309014155 Yip1 domain; Region: Yip1; cl17815 281309014156 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 281309014157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281309014158 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 281309014159 FtsX-like permease family; Region: FtsX; pfam02687 281309014160 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281309014161 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281309014162 Walker A/P-loop; other site 281309014163 ATP binding site [chemical binding]; other site 281309014164 Q-loop/lid; other site 281309014165 ABC transporter signature motif; other site 281309014166 Walker B; other site 281309014167 D-loop; other site 281309014168 H-loop/switch region; other site 281309014169 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 281309014170 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 281309014171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309014172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309014173 non-specific DNA binding site [nucleotide binding]; other site 281309014174 salt bridge; other site 281309014175 sequence-specific DNA binding site [nucleotide binding]; other site 281309014176 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 281309014177 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 281309014178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309014179 putative substrate translocation pore; other site 281309014180 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 281309014181 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 281309014182 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 281309014183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309014184 dimerization interface [polypeptide binding]; other site 281309014185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309014186 dimer interface [polypeptide binding]; other site 281309014187 phosphorylation site [posttranslational modification] 281309014188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309014189 ATP binding site [chemical binding]; other site 281309014190 Mg2+ binding site [ion binding]; other site 281309014191 G-X-G motif; other site 281309014192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309014193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014194 active site 281309014195 phosphorylation site [posttranslational modification] 281309014196 intermolecular recognition site; other site 281309014197 dimerization interface [polypeptide binding]; other site 281309014198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309014199 DNA binding site [nucleotide binding] 281309014200 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 281309014201 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 281309014202 NAD binding site [chemical binding]; other site 281309014203 homodimer interface [polypeptide binding]; other site 281309014204 active site 281309014205 substrate binding site [chemical binding]; other site 281309014206 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 281309014207 active site 281309014208 catalytic triad [active] 281309014209 oxyanion hole [active] 281309014210 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 281309014211 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 281309014212 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 281309014213 trimer interface [polypeptide binding]; other site 281309014214 active site 281309014215 substrate binding site [chemical binding]; other site 281309014216 CoA binding site [chemical binding]; other site 281309014217 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 281309014218 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 281309014219 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 281309014220 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 281309014221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281309014222 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 281309014223 integral membrane protein MviN; Region: mviN; TIGR01695 281309014224 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 281309014225 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 281309014226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281309014227 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 281309014228 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 281309014229 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 281309014230 Bacterial sugar transferase; Region: Bac_transf; pfam02397 281309014231 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 281309014232 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 281309014233 active site 281309014234 tetramer interface; other site 281309014235 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 281309014236 PHP domain; Region: PHP; pfam02811 281309014237 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 281309014238 AAA domain; Region: AAA_31; pfam13614 281309014239 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 281309014240 Chain length determinant protein; Region: Wzz; pfam02706 281309014241 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 281309014242 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 281309014243 AAA domain; Region: AAA_31; pfam13614 281309014244 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 281309014245 rod shape-determining protein Mbl; Provisional; Region: PRK13928 281309014246 MreB and similar proteins; Region: MreB_like; cd10225 281309014247 nucleotide binding site [chemical binding]; other site 281309014248 Mg binding site [ion binding]; other site 281309014249 putative protofilament interaction site [polypeptide binding]; other site 281309014250 RodZ interaction site [polypeptide binding]; other site 281309014251 sporulation transcriptional regulator SpoIIID; Region: spore_III_D; TIGR02844 281309014252 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281309014253 Peptidase family M23; Region: Peptidase_M23; pfam01551 281309014254 ABC-2 type transporter; Region: ABC2_membrane; cl17235 281309014255 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 281309014256 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309014257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309014258 Walker A/P-loop; other site 281309014259 ATP binding site [chemical binding]; other site 281309014260 Q-loop/lid; other site 281309014261 ABC transporter signature motif; other site 281309014262 Walker B; other site 281309014263 D-loop; other site 281309014264 H-loop/switch region; other site 281309014265 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281309014266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281309014267 Walker A/P-loop; other site 281309014268 ATP binding site [chemical binding]; other site 281309014269 Q-loop/lid; other site 281309014270 ABC transporter signature motif; other site 281309014271 Walker B; other site 281309014272 D-loop; other site 281309014273 H-loop/switch region; other site 281309014274 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 281309014275 LytTr DNA-binding domain; Region: LytTR; pfam04397 281309014276 stage II sporulation protein D; Region: spore_II_D; TIGR02870 281309014277 Stage II sporulation protein; Region: SpoIID; pfam08486 281309014278 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 281309014279 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 281309014280 hinge; other site 281309014281 active site 281309014282 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 281309014283 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 281309014284 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 281309014285 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 281309014286 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 281309014287 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 281309014288 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 281309014289 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 281309014290 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 281309014291 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 281309014292 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 281309014293 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 281309014294 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 281309014295 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 281309014296 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 281309014297 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 281309014298 NADH dehydrogenase subunit C; Validated; Region: PRK07735 281309014299 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 281309014300 NADH dehydrogenase subunit B; Validated; Region: PRK06411 281309014301 NADH dehydrogenase subunit A; Validated; Region: PRK07756 281309014302 PAS domain; Region: PAS_9; pfam13426 281309014303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309014304 putative active site [active] 281309014305 heme pocket [chemical binding]; other site 281309014306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309014307 metal binding site [ion binding]; metal-binding site 281309014308 active site 281309014309 I-site; other site 281309014310 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309014311 Protein of unknown function (DUF975); Region: DUF975; cl10504 281309014312 Protein of unknown function (DUF975); Region: DUF975; cl10504 281309014313 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 281309014314 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 281309014315 gamma subunit interface [polypeptide binding]; other site 281309014316 epsilon subunit interface [polypeptide binding]; other site 281309014317 LBP interface [polypeptide binding]; other site 281309014318 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 281309014319 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 281309014320 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 281309014321 alpha subunit interaction interface [polypeptide binding]; other site 281309014322 Walker A motif; other site 281309014323 ATP binding site [chemical binding]; other site 281309014324 Walker B motif; other site 281309014325 inhibitor binding site; inhibition site 281309014326 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 281309014327 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 281309014328 core domain interface [polypeptide binding]; other site 281309014329 delta subunit interface [polypeptide binding]; other site 281309014330 epsilon subunit interface [polypeptide binding]; other site 281309014331 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 281309014332 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 281309014333 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 281309014334 beta subunit interaction interface [polypeptide binding]; other site 281309014335 Walker A motif; other site 281309014336 ATP binding site [chemical binding]; other site 281309014337 Walker B motif; other site 281309014338 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 281309014339 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 281309014340 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 281309014341 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 281309014342 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 281309014343 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 281309014344 ATP synthase I chain; Region: ATP_synt_I; pfam03899 281309014345 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 281309014346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281309014347 active site 281309014348 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 281309014349 dimer interface [polypeptide binding]; other site 281309014350 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 281309014351 active site 281309014352 glycine-pyridoxal phosphate binding site [chemical binding]; other site 281309014353 folate binding site [chemical binding]; other site 281309014354 hypothetical protein; Provisional; Region: PRK13690 281309014355 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 281309014356 Low molecular weight phosphatase family; Region: LMWPc; cd00115 281309014357 active site 281309014358 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 281309014359 HPr interaction site; other site 281309014360 glycerol kinase (GK) interaction site [polypeptide binding]; other site 281309014361 active site 281309014362 phosphorylation site [posttranslational modification] 281309014363 Predicted membrane protein [Function unknown]; Region: COG2259 281309014364 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 281309014365 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 281309014366 oligomer interface [polypeptide binding]; other site 281309014367 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 281309014368 Predicted membrane protein [Function unknown]; Region: COG1971 281309014369 Domain of unknown function DUF; Region: DUF204; pfam02659 281309014370 Domain of unknown function DUF; Region: DUF204; pfam02659 281309014371 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 281309014372 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 281309014373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309014374 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 281309014375 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 281309014376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309014377 S-adenosylmethionine binding site [chemical binding]; other site 281309014378 peptide chain release factor 1; Validated; Region: prfA; PRK00591 281309014379 This domain is found in peptide chain release factors; Region: PCRF; smart00937 281309014380 RF-1 domain; Region: RF-1; pfam00472 281309014381 thymidine kinase; Provisional; Region: PRK04296 281309014382 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 281309014383 transcription termination factor Rho; Provisional; Region: rho; PRK09376 281309014384 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 281309014385 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 281309014386 RNA binding site [nucleotide binding]; other site 281309014387 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 281309014388 multimer interface [polypeptide binding]; other site 281309014389 Walker A motif; other site 281309014390 ATP binding site [chemical binding]; other site 281309014391 Walker B motif; other site 281309014392 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 281309014393 putative active site [active] 281309014394 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 281309014395 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 281309014396 hinge; other site 281309014397 active site 281309014398 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 281309014399 intersubunit interface [polypeptide binding]; other site 281309014400 active site 281309014401 zinc binding site [ion binding]; other site 281309014402 Na+ binding site [ion binding]; other site 281309014403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014404 active site 281309014405 phosphorylation site [posttranslational modification] 281309014406 intermolecular recognition site; other site 281309014407 dimerization interface [polypeptide binding]; other site 281309014408 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 281309014409 CTP synthetase; Validated; Region: pyrG; PRK05380 281309014410 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 281309014411 Catalytic site [active] 281309014412 active site 281309014413 UTP binding site [chemical binding]; other site 281309014414 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 281309014415 active site 281309014416 putative oxyanion hole; other site 281309014417 catalytic triad [active] 281309014418 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 281309014419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309014420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309014421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281309014422 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 281309014423 FAD binding site [chemical binding]; other site 281309014424 homotetramer interface [polypeptide binding]; other site 281309014425 substrate binding pocket [chemical binding]; other site 281309014426 catalytic base [active] 281309014427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281309014428 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 281309014429 FAD binding site [chemical binding]; other site 281309014430 homotetramer interface [polypeptide binding]; other site 281309014431 substrate binding pocket [chemical binding]; other site 281309014432 catalytic base [active] 281309014433 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 281309014434 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 281309014435 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 281309014436 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 281309014437 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 281309014438 dimer interface [polypeptide binding]; other site 281309014439 active site 281309014440 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 281309014441 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 281309014442 Cysteine-rich domain; Region: CCG; pfam02754 281309014443 Cysteine-rich domain; Region: CCG; pfam02754 281309014444 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 281309014445 PLD-like domain; Region: PLDc_2; pfam13091 281309014446 putative active site [active] 281309014447 catalytic site [active] 281309014448 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 281309014449 PLD-like domain; Region: PLDc_2; pfam13091 281309014450 putative active site [active] 281309014451 catalytic site [active] 281309014452 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 281309014453 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 281309014454 PAS domain S-box; Region: sensory_box; TIGR00229 281309014455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309014456 putative active site [active] 281309014457 heme pocket [chemical binding]; other site 281309014458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309014459 metal binding site [ion binding]; metal-binding site 281309014460 active site 281309014461 I-site; other site 281309014462 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 281309014463 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 281309014464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281309014465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281309014466 non-specific DNA binding site [nucleotide binding]; other site 281309014467 salt bridge; other site 281309014468 sequence-specific DNA binding site [nucleotide binding]; other site 281309014469 TPR repeat; Region: TPR_11; pfam13414 281309014470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309014471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014472 active site 281309014473 phosphorylation site [posttranslational modification] 281309014474 intermolecular recognition site; other site 281309014475 dimerization interface [polypeptide binding]; other site 281309014476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309014477 DNA binding residues [nucleotide binding] 281309014478 dimerization interface [polypeptide binding]; other site 281309014479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309014480 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 281309014481 Histidine kinase; Region: HisKA_3; pfam07730 281309014482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309014483 ATP binding site [chemical binding]; other site 281309014484 Mg2+ binding site [ion binding]; other site 281309014485 G-X-G motif; other site 281309014486 Acyltransferase family; Region: Acyl_transf_3; cl19154 281309014487 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 281309014488 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309014489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281309014490 Walker A/P-loop; other site 281309014491 ATP binding site [chemical binding]; other site 281309014492 Q-loop/lid; other site 281309014493 ABC transporter signature motif; other site 281309014494 Walker B; other site 281309014495 D-loop; other site 281309014496 H-loop/switch region; other site 281309014497 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 281309014498 active site 281309014499 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 281309014500 Domain of Unknown Function (DUF959); Region: DUF959; pfam06121 281309014501 Collagen binding domain; Region: Collagen_bind; pfam05737 281309014502 Collagen binding domain; Region: Collagen_bind; pfam05737 281309014503 Collagen binding domain; Region: Collagen_bind; pfam05737 281309014504 Collagen binding domain; Region: Collagen_bind; pfam05737 281309014505 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014506 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014507 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014508 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014509 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014510 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014511 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014512 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 281309014513 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014514 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014515 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014516 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 281309014517 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014518 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014519 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014520 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014521 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014522 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014523 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014524 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 281309014525 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014526 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014527 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014528 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014529 Cna protein B-type domain; Region: Cna_B; pfam05738 281309014530 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 281309014531 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 281309014532 PA/protease or protease-like domain interface [polypeptide binding]; other site 281309014533 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 281309014534 metal binding site [ion binding]; metal-binding site 281309014535 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 281309014536 RNA polymerase sigma factor; Provisional; Region: PRK12522 281309014537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281309014538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281309014539 DNA binding residues [nucleotide binding] 281309014540 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 281309014541 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 281309014542 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 281309014543 active site 281309014544 HIGH motif; other site 281309014545 KMSK motif region; other site 281309014546 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 281309014547 tRNA binding surface [nucleotide binding]; other site 281309014548 anticodon binding site; other site 281309014549 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 281309014550 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 281309014551 putative dimer interface [polypeptide binding]; other site 281309014552 catalytic triad [active] 281309014553 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 281309014554 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 281309014555 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 281309014556 putative active site [active] 281309014557 Mn binding site [ion binding]; other site 281309014558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309014559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309014560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281309014561 putative substrate translocation pore; other site 281309014562 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 281309014563 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 281309014564 DNA binding residues [nucleotide binding] 281309014565 putative dimer interface [polypeptide binding]; other site 281309014566 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 281309014567 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 281309014568 active site 281309014569 catalytic site [active] 281309014570 metal binding site [ion binding]; metal-binding site 281309014571 dimer interface [polypeptide binding]; other site 281309014572 Transglycosylase; Region: Transgly; pfam00912 281309014573 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281309014574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 281309014575 YwhD family; Region: YwhD; pfam08741 281309014576 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 281309014577 Peptidase family M50; Region: Peptidase_M50; pfam02163 281309014578 active site 281309014579 putative substrate binding region [chemical binding]; other site 281309014580 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 281309014581 active site 1 [active] 281309014582 dimer interface [polypeptide binding]; other site 281309014583 hexamer interface [polypeptide binding]; other site 281309014584 active site 2 [active] 281309014585 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 281309014586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281309014587 Zn2+ binding site [ion binding]; other site 281309014588 Mg2+ binding site [ion binding]; other site 281309014589 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 281309014590 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 281309014591 intersubunit interface [polypeptide binding]; other site 281309014592 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281309014593 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281309014594 Walker A/P-loop; other site 281309014595 ATP binding site [chemical binding]; other site 281309014596 Q-loop/lid; other site 281309014597 ABC transporter signature motif; other site 281309014598 Walker B; other site 281309014599 D-loop; other site 281309014600 H-loop/switch region; other site 281309014601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309014602 ABC-ATPase subunit interface; other site 281309014603 dimer interface [polypeptide binding]; other site 281309014604 putative PBP binding regions; other site 281309014605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281309014606 ABC-ATPase subunit interface; other site 281309014607 dimer interface [polypeptide binding]; other site 281309014608 putative PBP binding regions; other site 281309014609 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 281309014610 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 281309014611 hypothetical protein; Provisional; Region: PRK12473 281309014612 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 281309014613 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 281309014614 putative heme peroxidase; Provisional; Region: PRK12276 281309014615 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281309014616 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 281309014617 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 281309014618 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 281309014619 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 281309014620 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 281309014621 Protein of unknown function (DUF423); Region: DUF423; pfam04241 281309014622 Ion channel; Region: Ion_trans_2; pfam07885 281309014623 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 281309014624 TrkA-N domain; Region: TrkA_N; pfam02254 281309014625 TrkA-C domain; Region: TrkA_C; pfam02080 281309014626 Sulfate transporter family; Region: Sulfate_transp; cl19250 281309014627 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 281309014628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309014629 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 281309014630 motif II; other site 281309014631 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 281309014632 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 281309014633 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 281309014634 ligand binding site [chemical binding]; other site 281309014635 active site 281309014636 UGI interface [polypeptide binding]; other site 281309014637 catalytic site [active] 281309014638 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 281309014639 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 281309014640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281309014641 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 281309014642 Walker A/P-loop; other site 281309014643 ATP binding site [chemical binding]; other site 281309014644 Q-loop/lid; other site 281309014645 ABC transporter signature motif; other site 281309014646 Walker B; other site 281309014647 D-loop; other site 281309014648 H-loop/switch region; other site 281309014649 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 281309014650 active site 281309014651 catalytic triad [active] 281309014652 oxyanion hole [active] 281309014653 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281309014654 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281309014655 DNA binding site [nucleotide binding] 281309014656 domain linker motif; other site 281309014657 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 281309014658 putative dimerization interface [polypeptide binding]; other site 281309014659 putative ligand binding site [chemical binding]; other site 281309014660 Predicted membrane protein [Function unknown]; Region: COG2364 281309014661 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 281309014662 homoserine dehydrogenase; Provisional; Region: PRK06349 281309014663 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 281309014664 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 281309014665 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 281309014666 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 281309014667 proposed active site lysine [active] 281309014668 conserved cys residue [active] 281309014669 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281309014670 homodimer interface [polypeptide binding]; other site 281309014671 substrate-cofactor binding pocket; other site 281309014672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281309014673 catalytic residue [active] 281309014674 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 281309014675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281309014676 active site 281309014677 motif I; other site 281309014678 motif II; other site 281309014679 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 281309014680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 281309014681 ligand binding site [chemical binding]; other site 281309014682 flexible hinge region; other site 281309014683 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 281309014684 azoreductase; Provisional; Region: PRK13556 281309014685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281309014686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014687 active site 281309014688 phosphorylation site [posttranslational modification] 281309014689 intermolecular recognition site; other site 281309014690 dimerization interface [polypeptide binding]; other site 281309014691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281309014692 DNA binding residues [nucleotide binding] 281309014693 dimerization interface [polypeptide binding]; other site 281309014694 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 281309014695 GAF domain; Region: GAF_3; pfam13492 281309014696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281309014697 Histidine kinase; Region: HisKA_3; pfam07730 281309014698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309014699 ATP binding site [chemical binding]; other site 281309014700 Mg2+ binding site [ion binding]; other site 281309014701 G-X-G motif; other site 281309014702 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 281309014703 dimer interface [polypeptide binding]; other site 281309014704 substrate binding site [chemical binding]; other site 281309014705 ATP binding site [chemical binding]; other site 281309014706 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 281309014707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 281309014708 metal binding site [ion binding]; metal-binding site 281309014709 active site 281309014710 I-site; other site 281309014711 Protein of unknown function (DUF466); Region: DUF466; pfam04328 281309014712 carbon starvation protein A; Provisional; Region: PRK15015 281309014713 Carbon starvation protein CstA; Region: CstA; pfam02554 281309014714 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 281309014715 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 281309014716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014717 active site 281309014718 phosphorylation site [posttranslational modification] 281309014719 intermolecular recognition site; other site 281309014720 dimerization interface [polypeptide binding]; other site 281309014721 LytTr DNA-binding domain; Region: LytTR; pfam04397 281309014722 benzoate transport; Region: 2A0115; TIGR00895 281309014723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309014724 putative substrate translocation pore; other site 281309014725 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 281309014726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281309014727 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 281309014728 Predicted membrane protein [Function unknown]; Region: COG2860 281309014729 UPF0126 domain; Region: UPF0126; pfam03458 281309014730 UPF0126 domain; Region: UPF0126; pfam03458 281309014731 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 281309014732 heme-binding site [chemical binding]; other site 281309014733 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 281309014734 dimer interface [polypeptide binding]; other site 281309014735 putative CheW interface [polypeptide binding]; other site 281309014736 conserved hypothetical integral membrane protein; Region: TIGR03766 281309014737 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 281309014738 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 281309014739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281309014740 active site 281309014741 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 281309014742 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 281309014743 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281309014744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309014745 ABC transporter; Region: ABC_tran_2; pfam12848 281309014746 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281309014747 conserved hypothetical integral membrane protein; Region: TIGR03766 281309014748 conserved hypothetical integral membrane protein; Region: TIGR03766 281309014749 GtrA-like protein; Region: GtrA; pfam04138 281309014750 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 281309014751 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 281309014752 Ligand binding site; other site 281309014753 Putative Catalytic site; other site 281309014754 DXD motif; other site 281309014755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309014756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309014757 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 281309014758 MMPL family; Region: MMPL; cl14618 281309014759 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 281309014760 MMPL family; Region: MMPL; cl14618 281309014761 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 281309014762 methionine sulfoxide reductase B; Provisional; Region: PRK00222 281309014763 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 281309014764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 281309014765 Transposase domain (DUF772); Region: DUF772; pfam05598 281309014766 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 281309014767 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281309014768 antiholin-like protein LrgB; Provisional; Region: PRK04288 281309014769 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 281309014770 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 281309014771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014772 active site 281309014773 phosphorylation site [posttranslational modification] 281309014774 intermolecular recognition site; other site 281309014775 dimerization interface [polypeptide binding]; other site 281309014776 LytTr DNA-binding domain; Region: LytTR; pfam04397 281309014777 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 281309014778 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 281309014779 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 281309014780 Histidine kinase; Region: His_kinase; pfam06580 281309014781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309014782 ATP binding site [chemical binding]; other site 281309014783 Mg2+ binding site [ion binding]; other site 281309014784 G-X-G motif; other site 281309014785 benzoate transport; Region: 2A0115; TIGR00895 281309014786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281309014787 putative substrate translocation pore; other site 281309014788 BCCT family transporter; Region: BCCT; pfam02028 281309014789 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 281309014790 active site 281309014791 dimer interface [polypeptide binding]; other site 281309014792 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 281309014793 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 281309014794 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 281309014795 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281309014796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281309014797 NAD(P) binding site [chemical binding]; other site 281309014798 active site 281309014799 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 281309014800 hexamer interface [polypeptide binding]; other site 281309014801 transport channel [chemical binding]; other site 281309014802 constriction site 1 [chemical binding]; other site 281309014803 constriction site 2 [chemical binding]; other site 281309014804 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 281309014805 UDP-glucose 4-epimerase; Region: PLN02240 281309014806 NAD binding site [chemical binding]; other site 281309014807 homodimer interface [polypeptide binding]; other site 281309014808 active site 281309014809 substrate binding site [chemical binding]; other site 281309014810 Haemolysin-III related; Region: HlyIII; cl03831 281309014811 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 281309014812 Predicted integral membrane protein [Function unknown]; Region: COG5542 281309014813 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 281309014814 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 281309014815 ATP binding site [chemical binding]; other site 281309014816 Mg++ binding site [ion binding]; other site 281309014817 motif III; other site 281309014818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281309014819 nucleotide binding region [chemical binding]; other site 281309014820 ATP-binding site [chemical binding]; other site 281309014821 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 281309014822 RNA binding site [nucleotide binding]; other site 281309014823 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 281309014824 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 281309014825 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 281309014826 active site 281309014827 oligoendopeptidase F; Region: pepF; TIGR00181 281309014828 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 281309014829 active site 281309014830 Zn binding site [ion binding]; other site 281309014831 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 281309014832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281309014833 FeS/SAM binding site; other site 281309014834 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 281309014835 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 281309014836 YyzF-like protein; Region: YyzF; pfam14116 281309014837 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 281309014838 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 281309014839 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 281309014840 protein binding site [polypeptide binding]; other site 281309014841 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 281309014842 YycH protein; Region: YycI; pfam09648 281309014843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 281309014844 YycH protein; Region: YycH; pfam07435 281309014845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 281309014846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281309014847 dimerization interface [polypeptide binding]; other site 281309014848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 281309014849 putative active site [active] 281309014850 heme pocket [chemical binding]; other site 281309014851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281309014852 dimer interface [polypeptide binding]; other site 281309014853 phosphorylation site [posttranslational modification] 281309014854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281309014855 ATP binding site [chemical binding]; other site 281309014856 Mg2+ binding site [ion binding]; other site 281309014857 G-X-G motif; other site 281309014858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281309014859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281309014860 active site 281309014861 phosphorylation site [posttranslational modification] 281309014862 intermolecular recognition site; other site 281309014863 dimerization interface [polypeptide binding]; other site 281309014864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281309014865 DNA binding site [nucleotide binding] 281309014866 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 281309014867 GDP-binding site [chemical binding]; other site 281309014868 ACT binding site; other site 281309014869 IMP binding site; other site 281309014870 replicative DNA helicase; Provisional; Region: PRK05748 281309014871 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 281309014872 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 281309014873 Walker A motif; other site 281309014874 ATP binding site [chemical binding]; other site 281309014875 Walker B motif; other site 281309014876 DNA binding loops [nucleotide binding] 281309014877 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 281309014878 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 281309014879 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 281309014880 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 281309014881 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 281309014882 DHH family; Region: DHH; pfam01368 281309014883 DHHA1 domain; Region: DHHA1; pfam02272 281309014884 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 281309014885 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 281309014886 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 281309014887 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 281309014888 dimer interface [polypeptide binding]; other site 281309014889 ssDNA binding site [nucleotide binding]; other site 281309014890 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281309014891 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 281309014892 GTP-binding protein YchF; Reviewed; Region: PRK09601 281309014893 YchF GTPase; Region: YchF; cd01900 281309014894 G1 box; other site 281309014895 GTP/Mg2+ binding site [chemical binding]; other site 281309014896 Switch I region; other site 281309014897 G2 box; other site 281309014898 Switch II region; other site 281309014899 G3 box; other site 281309014900 G4 box; other site 281309014901 G5 box; other site 281309014902 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 281309014903 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 281309014904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 281309014905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 281309014906 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 281309014907 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 281309014908 ParB-like nuclease domain; Region: ParB; smart00470 281309014909 KorB domain; Region: KorB; pfam08535 281309014910 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 281309014911 VirC1 protein; Region: VirC1; cl17401 281309014912 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 281309014913 P-loop; other site 281309014914 Magnesium ion binding site [ion binding]; other site 281309014915 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 281309014916 ParB-like nuclease domain; Region: ParBc; pfam02195 281309014917 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 281309014918 Methyltransferase domain; Region: Methyltransf_31; pfam13847 281309014919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281309014920 S-adenosylmethionine binding site [chemical binding]; other site 281309014921 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 281309014922 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 281309014923 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 281309014924 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 281309014925 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 281309014926 trmE is a tRNA modification GTPase; Region: trmE; cd04164 281309014927 G1 box; other site 281309014928 GTP/Mg2+ binding site [chemical binding]; other site 281309014929 Switch I region; other site 281309014930 G2 box; other site 281309014931 Switch II region; other site 281309014932 G3 box; other site 281309014933 G4 box; other site 281309014934 G5 box; other site 281309014935 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 281309014936 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 281309014937 Jag N-terminus; Region: Jag_N; pfam14804 281309014938 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 281309014939 G-X-X-G motif; other site 281309014940 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 281309014941 RxxxH motif; other site 281309014942 OxaA-like protein precursor; Validated; Region: PRK02944 281309014943 ribonuclease P; Reviewed; Region: rnpA; PRK00499 281309014944 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 281309014945 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 281309014946 Lysozyme-like; Region: Lysozyme_like; pfam13702 281309014947 NlpC/P60 family; Region: NLPC_P60; pfam00877 281309014948 AAA-like domain; Region: AAA_10; pfam12846 281309014949 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 281309014950 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 281309014951 Walker A motif; other site 281309014952 ATP binding site [chemical binding]; other site 281309014953 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 281309014954 Walker B motif; other site 281309014955 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 281309014956 TrbC/VIRB2 family; Region: TrbC; pfam04956 281309014957 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 281309014958 Walker A motif; other site 281309014959 ATP binding site [chemical binding]; other site 281309014960 Walker B motif; other site 281309014961 hypothetical protein; Provisional; Region: PRK12856 281309014962 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 281309014963 Uncharacterized conserved protein [Function unknown]; Region: COG1683 281309014964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281309014965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281309014966 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 281309014967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 281309014968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281309014969 Coenzyme A binding pocket [chemical binding]; other site 281309014970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281309014971 Sm and related proteins; Region: Sm_like; cl00259 281309014972 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 281309014973 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 281309014974 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 281309014975 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 281309014976 P-loop; other site 281309014977 Magnesium ion binding site [ion binding]; other site 281309014978 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 281309014979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281309014980 dimerization interface [polypeptide binding]; other site 281309014981 putative DNA binding site [nucleotide binding]; other site 281309014982 putative Zn2+ binding site [ion binding]; other site 281309014983 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 281309014984 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 281309014985 peptide binding site [polypeptide binding]; other site 281309014986 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 281309014987 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 281309014988 cofactor binding site; other site 281309014989 DNA binding site [nucleotide binding] 281309014990 substrate interaction site [chemical binding]; other site 281309014991 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 281309014992 DNA binding residues [nucleotide binding] 281309014993 DNA polymerase IV; Reviewed; Region: PRK03103 281309014994 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 281309014995 active site 281309014996 DNA binding site [nucleotide binding] 281309014997 YolD-like protein; Region: YolD; pfam08863 281309014998 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281309014999 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 281309015000 catalytic residues [active] 281309015001 catalytic nucleophile [active] 281309015002 Presynaptic Site I dimer interface [polypeptide binding]; other site 281309015003 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 281309015004 Synaptic Flat tetramer interface [polypeptide binding]; other site 281309015005 Synaptic Site I dimer interface [polypeptide binding]; other site 281309015006 DNA binding site [nucleotide binding] 281309015007 integron integrase; Region: integrase_gron; TIGR02249 281309015008 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 281309015009 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281309015010 active site 281309015011 catalytic residues [active] 281309015012 DNA binding site [nucleotide binding] 281309015013 Int/Topo IB signature motif; other site 281309015014 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 281309015015 CAAX protease self-immunity; Region: Abi; pfam02517 281309015016 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 281309015017 DNA topoisomerase III; Provisional; Region: PRK07726 281309015018 active site 281309015019 putative interdomain interaction site [polypeptide binding]; other site 281309015020 putative metal-binding site [ion binding]; other site 281309015021 putative nucleotide binding site [chemical binding]; other site 281309015022 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 281309015023 domain I; other site 281309015024 DNA binding groove [nucleotide binding] 281309015025 phosphate binding site [ion binding]; other site 281309015026 domain II; other site 281309015027 domain III; other site 281309015028 nucleotide binding site [chemical binding]; other site 281309015029 catalytic site [active] 281309015030 domain IV; other site 281309015031 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 281309015032 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 281309015033 CHC2 zinc finger; Region: zf-CHC2; cl17510 281309015034 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 281309015035 Toprim-like; Region: Toprim_2; pfam13155 281309015036 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307